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https://www.readbyqxmd.com/read/28153774/patterns-of-care-and-survival-outcomes-for-adolescent-and-young-adult-patients-with-testicular-seminoma-in-the-united-states-a-national-cancer-database-analysis
#1
William Stokes, Arya Amini, Paul D Maroni, Elizabeth R Kessler, Claire Stokes, Carrye R Cost, Brian S Greffe, Timothy P Garrington, Arthur K Liu, Nicholas G Cost
INTRODUCTION: Testicular germ cell tumors (GCTs) are the most common solid tumor among adolescent and young adult (AYA) males. AYA patients with GCTs most typically have non-seminoma compared with seminoma, and accordingly there are fewer data reported on the AYA experience with testicular seminoma. OBJECTIVE: To evaluate national trends in postoperative treatment and overall survival (OS) outcomes in testicular seminoma by age group, specifically comparing AYAs with older adults...
January 17, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28068279/identifying-predictors-of-central-sleep-apnea-cheyne-stokes-breathing-in-chronic-heart-failure-a-pathophysiological-approach
#2
Aneliya I Draganova, Kiril V Terziyski, Stefan S Kostianev
Chronic heart failure (CHF) is a major health problem associated with increased mortality, despite modern treatment options. Central sleep apnea (CSA)/Cheyne-Stokes breathing (CSB) is a common and yet largely under-diagnosed co-morbidity, adding significantly to the poor prognosis in CHF because of a number of acute and chronic effects, including intermittent hypoxia, sympathetic overactivation, disturbed sleep architecture and impaired physical tolerance. It is characterized by repetitive periods of crescendo-decrescendo ventilatory pattern, alternating with central apneas and hypopneas...
December 1, 2016: Folia Medica
https://www.readbyqxmd.com/read/28059913/liposomal-bupivacaine-use-in-transversus-abdominis-plane-blocks-reduces-pain-and-postoperative-intravenous-opioid-requirement-after-colorectal-surgery
#3
Audrey L Stokes, Sanjib D Adhikary, Ashley Quintili, Frances J Puleo, Christine S Choi, Christopher S Hollenbeak, Evangelos Messaris
BACKGROUND: Enhanced recovery protocols frequently use multimodal postoperative analgesia to improve postoperative outcomes in patients undergoing colorectal surgery. OBJECTIVE: The purpose of this study was to evaluate liposomal bupivacaine use in transversus abdominis plane blocks on postoperative pain scores and opioid use after colorectal surgery. DESIGN: This was a retrospective cohort study comparing outcomes between patients receiving nonliposomal anesthetic (n = 104) and liposomal bupivacaine (n = 303) blocks...
February 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28052510/plant-diversity-enhances-moth-diversity-in-an-intensive-forest-management-experiment
#4
Heather T Root, Jake Verschuyl, Thomas Stokely, Paul Hammond, Melissa A Scherr, Matthew G Betts
Intensive forest management (IFM) promises to help satisfy increasing global demand for wood but may come at the cost of local reductions to forest biodiversity. IFM often reduces early seral plant diversity as a result of efforts to eliminate plant competition with crop trees. If diversity is a function of bottom-up drivers, theory predicts that specialists at lower trophic levels (e.g., insect herbivores) should be particularly sensitive to reductions in plant diversity. We conducted a stand-level experiment to test bottom-up controls on moth community structure, as mediated by degrees of forest management intensity...
January 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28005844/random-brillouin-fiber-laser-for-tunable-ultra-narrow-linewidth-microwave-generation
#5
Dao Xiang, Ping Lu, Yanping Xu, Liang Chen, Xiaoyi Bao
Studies about random lasing phenomena taking place in disordered structures with amplification are gaining great interest, as they can support dual wavelength lasing without cavity length restriction and, hence, the tunable beat frequency in a microwave can be created in a random cavity and be amplified for applications in the information and communication technology. Here, we present a novel random Brillouin fiber laser scheme using the stimulated Brillouin scattering as gain and strong Rayleigh scattering feedback (10 km) in the single-mode fiber...
October 15, 2016: Optics Letters
https://www.readbyqxmd.com/read/27995368/cost-of-informal-care-for-patients-with-cardiovascular-disease-or-diabetes-current-evidence-and-research-challenges
#6
REVIEW
Heesoo Joo, Ping Zhang, Guijing Wang
PURPOSE: Patients with cardiovascular disease (CVD) or diabetes often require informal care. The burden of informal care, however, was not fully integrated into economic evaluation. We conducted a literature review to summarize the current evidence on economic burden associated with informal care imposed by CVD or diabetes. METHODS: We searched EconLit, EMBASE, and PubMed for publications in English during the period of 1995-2015. Keywords for the search were informal care cost, costs of informal care, informal care, and economic burden...
December 19, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27910659/the-multi-spectral-line-polarization-mse-system-on-alcator-c-mod
#7
R T Mumgaard, S D Scott, M Khoury
A multi-spectral line-polarization motional Stark effect (MSE-MSLP) diagnostic has been developed for the Alcator C-Mod tokamak wherein the Stokes vector is measured in multiple wavelength bands simultaneously on the same sightline to enable better polarized background subtraction. A ten-sightline, four wavelength MSE-MSLP detector system was designed, constructed, and qualified. This system consists of a high-throughput polychromator for each sightline designed to provide large étendue and precise spectral filtering in a cost-effective manner...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27900170/low-fitness-low-body-mass-and-prior-injury-predict-injury-risk-during-military-recruit-training-a-prospective-cohort-study-in-the-british-army
#8
Mark Robinson, Andrew Siddall, James Bilzon, Dylan Thompson, Julie Greeves, Rachel Izard, Keith Stokes
BACKGROUND: Injuries sustained by military recruits during initial training impede training progression and military readiness while increasing financial costs. This study investigated training-related injuries and injury risk factors among British Army infantry recruits. METHODS: Recruits starting infantry training at the British Army Infantry Training Centre between September 2008 and March 2010 were eligible to take part. Information regarding lifestyle behaviours and injury history was collected using the Military Pre-training Questionnaire...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27857406/joint-cd-and-pmd-monitoring-based-on-a-pair-of-low-bandwidth-coherent-receivers
#9
Yuli Chen, Qi Sui, Zhaohui Li, Zihao Liang, Weiping Liu
A joint chromatic dispersion (CD) and 1st order polarization mode dispersion (PMD) monitoring technique for both a coherent and a non-coherent single carrier system based on a pair of cost effective low-bandwidth coherent receivers is proposed and experimentally demonstrated. By jointly detecting the narrow band around ± 1/2 baud rate, the CD and PMD can be estimated simultaneously by time domain correlation and Stokes space rotational angle recovery, respectively. The CD estimation range is theoretically infinite and the PMD estimation range is limited to the maximum of 1/2 symbol period...
November 14, 2016: Optics Express
https://www.readbyqxmd.com/read/27779114/novel-one-pot-and-facile-room-temperature-synthesis-of-gold-nanodots-and-application-as-highly-sensitive-and-selective-probes-for-cyanide-detection
#10
Nagamalai Vasimalai, Maria T Fernandez-Arguelles
Highly fluorescent gold nanodots have been synthesized through a novel rapid, facile and one-pot room temperature route using trithiocyanuric acid as mild reducing agent and surface ligand. The proposed synthesis overcomes limitations of other synthetic routes in terms of cost, time, complexity and environmental risks, and gives rise to highly fluorescent gold nanodots within 10 min at room temperature, with a maximum emission wavelength at 623 nm and a large Stokes shift (213 nm). Moreover, the synthesized gold nanodots showed a large emission QY (9...
November 25, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27770807/barriers-and-enablers-to-guideline-implementation-strategies-to-improve-obstetric-care-practice-in-low-and-middle-income-countries-a-systematic-review-of-qualitative-evidence
#11
Tim Stokes, Elizabeth J Shaw, Janette Camosso-Stefinovic, Mari Imamura, Lovney Kanguru, Julia Hussein
BACKGROUND: Maternal mortality remains a major international health problem in low- and middle-income countries (LMIC), and most could have been prevented by quality improvement interventions already demonstrated to be effective, such as clinical guideline implementation strategies. The aim of this systematic review was to synthesise qualitative evidence on guideline implementation strategies to improve obstetric care practice in LMIC in order to identify barriers and enablers to their successful implementation...
October 22, 2016: Implementation Science: IS
https://www.readbyqxmd.com/read/27759432/unmet-need-for-specialised-rehabilitation-following-neurosurgery-can-we-maximise-the-potential-cost-benefits
#12
Rajiv Singh, Saurabh Sinha, Alan Bill, Lynne Turner-Stokes
OBJECTIVE: To identify the needs for specialised rehabilitation provision in a cohort of neurosurgical patients; to determine if these were met, and to estimate the potential cost implications and cost-benefits of meeting any unmet rehabilitation needs. METHODS: A prospective study of in-patient admissions to a regional neurosurgical ward. Assessment of needs for specialised rehabilitation (Category A or B needs) was made with the Patient Categorisation Tool. The number of patients who were referred and admitted for specialised rehabilitation was calculated...
October 19, 2016: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/27713016/a-cell-based-approach-to-characterize-antimicrobial-compounds-through-kinetic-dose-response
#13
Craig R MacNair, Jonathan M Stokes, Shawn French, Cullen L Myers, Kali R Iyer, Eric D Brown
The rapid spread of antibiotic resistance has created a pressing need for the development of novel drug screening platforms. Herein, we report on the use of cell-based kinetic dose response curves for small molecule characterization in antibiotic discovery efforts. Kinetically monitoring bacterial growth at sub-inhibitory concentrations of antimicrobial small molecules generates unique dose response profiles. We show that clustering of profiles by growth characteristics can classify antibiotics by mechanism of action...
December 15, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27697605/design-and-implementation-of-the-airways-2-trial-a-multi-centre-cluster-randomised-controlled-trial-of-the-clinical-and-cost-effectiveness-of-the-i-gel-supraglottic-airway-device-versus-tracheal-intubation-in-the-initial-airway-management-of-out-of-hospital
#14
Jodi Taylor, Sarah Black, Stephen J Brett, Kim Kirby, Jerry P Nolan, Barnaby C Reeves, Maria Robinson, Chris A Rogers, Lauren J Scott, Adrian South, Elizabeth A Stokes, Matthew Thomas, Sarah Voss, Sarah Wordsworth, Jonathan R Benger
Health outcomes after out of hospital cardiac arrest (OHCA) are extremely poor, with only 7-9% of patients in the United Kingdom (UK) surviving to hospital discharge. Currently emergency medical services (EMS) use either tracheal intubation or newer supraglottic airway devices (SGAs) to provide advanced airway management during OHCA. Equipoise between the two techniques has led to calls for a well-designed randomised controlled trial. The primary objective of the AIRWAYS-2 trial is to assess whether the clinical effectiveness of the i-gel, a second-generation SGA, is superior to tracheal intubation in the initial airway management of OHCA patients in the UK...
December 2016: Resuscitation
https://www.readbyqxmd.com/read/27650217/simulation-of-gaseous-pollutant-dispersion-around-an-isolated-building-using-the-k-%C3%AF-sst-turbulence-model
#15
Hesheng Yu, Jesse Thé
: The dispersion of gaseous pollutant around buildings is complex due to complex turbulence features such as flow detachment and zones of high shear. Computational fluid dynamics (CFD) models are one of the most promising tools to describe the pollutant distribution in the near field of buildings. Reynolds Average Navier-Stokes (RANS) models are the most commonly used CFD techniques to address turbulence transport of the pollutant. This research work studies the use of [Formula: see text]closure model for the gas dispersion around a building by fully resolving the viscous sublayer for the first time...
September 20, 2016: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/27649332/a-nuclease-assisted-label-free-aptasensor-for-fluorescence-turn-on-detection-of-atp-based-on-the-in-situ-formation-of-copper-nanoparticles
#16
Quanwei Song, Ruihua Wang, Feifei Sun, Hongkun Chen, Zoumengke Wang, Na Na, Jin Ouyang
Owing to their promising advantages in biochemical analysis, aptamer-based sensing systems for the fluorescence detection of important biomolecules are being extensively investigated. Herein, we propose a turn-on fluorescent aptasensor for label-free detection of adenosine triphosphate (ATP) by utilizing the in situ formation of copper nanoparticles (CuNPs) and the specific digestion capability of exonuclease I (Exo I). In this assay, the addition of ATP can effectively hinder the digestion of aptamer-derived oligonucleotides due to the G-quadruplex structure...
January 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27627418/simplification-of-the-unified-gas-kinetic-scheme
#17
Songze Chen, Zhaoli Guo, Kun Xu
The unified gas kinetic scheme (UGKS) is an asymptotic preserving (AP) scheme for kinetic equations. It is superior for transition flow simulation and has been validated in the past years. However, compared to the well-known discrete ordinate method (DOM), which is a classical numerical method solving the kinetic equations, the UGKS needs more computational resources. In this study, we propose a simplification of the unified gas kinetic scheme. It allows almost identical numerical cost as the DOM, but predicts numerical results as accurate as the UGKS...
August 2016: Physical Review. E
https://www.readbyqxmd.com/read/27609852/cost-efficiency-of-specialist-hyperacute-in-patient-rehabilitation-services-for-medically-unstable-patients-with-complex-rehabilitation-needs-a-prospective-cohort-analysis
#18
Lynne Turner-Stokes, Ganesh Bavikatte, Heather Williams, Alan Bill, Keith Sephton
OBJECTIVES: To evaluate functional outcomes, care needs and cost-efficiency of hyperacute (HA) rehabilitation for a cohort of in-patients with complex neurological disability and unstable medical/surgical conditions. DESIGN: A multicentre cohort analysis of prospectively collected clinical data from the UK Rehabilitation Outcomes Collaborative (UKROC) national clinical database, 2012-2015. SETTING: Two HA specialist rehabilitation services in England, providing different service models for HA rehabilitation...
September 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27598248/associations-between-extending-access-to-primary-care-and-emergency-department-visits-a-difference-in-differences-analysis
#19
William Whittaker, Laura Anselmi, Søren Rud Kristensen, Yiu-Shing Lau, Simon Bailey, Peter Bower, Katherine Checkland, Rebecca Elvey, Katy Rothwell, Jonathan Stokes, Damian Hodgson
BACKGROUND: Health services across the world increasingly face pressures on the use of expensive hospital services. Better organisation and delivery of primary care has the potential to manage demand and reduce costs for hospital services, but routine primary care services are not open during evenings and weekends. Extended access (evening and weekend opening) is hypothesized to reduce pressure on hospital services from emergency department visits. However, the existing evidence-base is weak, largely focused on emergency out-of-hours services, and analysed using a before-and after-methodology without effective comparators...
September 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27594707/an-adaptable-parallel-algorithm-for-the-direct-numerical-simulation-of-incompressible-turbulent-flows-using-a-fourier-spectral-hp-element-method-and-mpi-virtual-topologies
#20
A Bolis, C D Cantwell, D Moxey, D Serson, S J Sherwin
A hybrid parallelisation technique for distributed memory systems is investigated for a coupled Fourier-spectral/hp element discretisation of domains characterised by geometric homogeneity in one or more directions. The performance of the approach is mathematically modelled in terms of operation count and communication costs for identifying the most efficient parameter choices. The model is calibrated to target a specific hardware platform after which it is shown to accurately predict the performance in the hybrid regime...
September 2016: Computer Physics Communications
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