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https://www.readbyqxmd.com/read/28526182/pharmacologic-management-of-type-2-diabetes-mellitus-available-therapies
#1
James Thrasher
Choices for the treatment of type 2 diabetes mellitus (T2DM) have multiplied as our understanding of the underlying pathophysiologic defects has evolved. Treatment should target multiple defects in T2DM and follow a patient-centered approach that considers factors beyond glycemic control, including cardiovascular risk reduction. The American Association of Clinical Endocrinologists/American College of Endocrinology and the American Diabetes Association recommend an initial approach consisting of lifestyle changes and monotherapy, preferably with metformin...
May 12, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28515848/coronary-artery-disease-detection-limitations-of-stress-testing-in-left-ventricular-dysfunction
#2
REVIEW
Ritin Bomb, Senthil Kumar, Anand Chockalingam
Incidental diagnosis of left ventricular systolic dysfunction (LVD) is common in clinical practice. The prevalence of asymptomatic LVD (Ejection Fraction, EF < 50%) is 6.0% in men and 0.8% in women and is twice as common as symptomatic LVD. The timely and definitive exclusion of an ischemic etiology is central to optimizing care and reducing mortality in LVD. Advances in cardiovascular imaging provide many options for imaging of patients with left ventricular dysfunction. Clinician experience, patient endurance, imaging modality characteristics, cost and safety determine the choice of testing...
April 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28515767/cost-effectiveness-evaluation-of-aspirin-in-primary-prevention-of-myocardial-infarction-amongst-males-with-average-cardiovascular-risk-in-iran
#3
Mohammadreza Amirsadri, Mohammad Javad Sedighi
Aspirin is one of the certified medicines commonly used for the secondary prevention of myocardial infarction (MI). Aspirin side effects and gastrointestinal bleeding, in particular, have arisen debates on its use for the primary prevention of MI. The present research evaluates the cost-effectiveness of the use of aspirin in the primary prevention of MI among Iranian men with average cardiovascular disease (CVD) risk, using Markov modeling technique. The incremental cost-effectiveness ratios (ICERs) estimated to be 864 USA dollars (USD) per quality-adjusted life years (QALY) gained and 782 USD per life years gained (LYG) for each patient in the base-case scenario (public tariffs and no discounting)...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28513399/reducing-health-inequalities-for-people-with-serious-mental-illness
#4
Nutmeg Hallett, Helen Rees
People with serious mental illness (SMI) are at risk of dying many years earlier than the general population. Providing an effective, cost-efficient healthcare service requires a holistic approach, and improving the physical health of people with SMI should be integral to all healthcare roles. It is important for nurses to identify and understand the barriers that people with SMI may experience when accessing physical healthcare. A range of factors contribute to reduced life expectancy, including lifestyle factors, symptoms of mental illness and the side effects of medications...
May 17, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28510527/the-seesaw-of-cvd-deaths-down-costs-up
#5
(no author information available yet)
Coronary heart disease deaths will decline by 30% between 2010 and 2020 because of improvement in "cardiovascular health metrics" (avoidance of smoking, more physical activity, and so on). But this less-deadly era of CVD is going to be a more costly one, with direct medical costs of CVD more than doubling by 2030 to $918 billion from $396 billion in 2012.
March 2017: Managed Care
https://www.readbyqxmd.com/read/28509889/the-role-of-nitrates-in-the-management-of-stable-ischemic-heart-disease-a-review-of-the-current-evidence-and-guidelines
#6
Mehul A Pragani, Karan P Desai, Doralisa Morrone, Mandeep S Sidhu, William E Boden
Coronary artery disease is the leading cause of mortality in the United States and can result in significant morbidity. In particular, stable ischemic heart disease (SIHD) is a condition that affects nearly 9 million individuals in the United States alone, with substantial annual health care costs related to recurrent medical visits and chronic disease management. Nitrates form a cornerstone of SIHD management by reducing myocardial oxygen consumption and increasing exercise capacity by several mechanisms, including increasing epicardial blood flow through vasodilation and decreased vascular resistance, blunting coronary steal, and reducing preload...
2017: Reviews in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28507654/cost-effectiveness-of-pharmacist-care-for-managing-hypertension-in-canada
#7
Carlo Marra, Karissa Johnston, Valerie Santschi, Ross T Tsuyuki
BACKGROUND: More than half of all heart disease and stroke are attributable to hypertension, which is associated with approximately 10% of direct medical costs globally. Clinical trial evidence has demonstrated that the benefits of pharmacist intervention, including education, consultation and/or prescribing, can help to reduce blood pressure; a recent Canadian trial found an 18.3 mmHg reduction in systolic blood pressure associated with pharmacist care and prescribing. The objective of this study was to evaluate the economic impact of such an intervention in a Canadian setting...
May 2017: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/28503458/quality-of-life-and-awareness-of-cardiac-rehabilitation-program-in-people-with-cardiovascular-diseases
#8
Sehi Kweon, Min Kyun Sohn, Jin Ok Jeong, Soojae Kim, Hyunkyu Jeon, Hyewon Lee, Seung-Chan Ahn, Soo Ho Park, Sungju Jee
OBJECTIVE: To evaluate the level of health-related quality of life (HRQoL), life satisfaction, and their present awareness of cardiac rehabilitation (CR) program in people with cardiovascular diseases. METHODS: A questionnaire survey was completed by 53 patients (mean age, 65.7±11.6 years; 33 men and 20 women) with unstable angina, myocardial infarction, or heart failure. The questionnaire included the Medical Outcome Study 36-item Short-Form Health Survey (MOS SF-36), life domain satisfaction measure (LDSM), and the awareness and degree of using CR program...
April 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28501745/paper-based-diagnostics-for-personalized-health-care-emerging-technologies-and-commercial-aspects
#9
REVIEW
Kuldeep Mahato, Ananya Srivastava, Pranjal Chandra
Personalized health care (PHC) is being appreciated globally to combat clinical complexities underlying various metabolic or infectious disorders including diabetes, cardiovascular, communicable diseases etc. Effective diagnoses majorly depend on initial identification of the causes which are nowadays being practiced in disease-oriented approach, where personal health profile is often overlooked. The adoption of PHC has shown significantly improved diagnoses in various conditions including emergency, ambulatory, and remote area...
May 1, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28501349/potential-health-impact-and-cost-effectiveness-of-drug-therapy-for-prehypertension
#10
Tao Chen, Dahai Yu, Victoria Cornelius, Rui Qin, Yamei Cai, Zhixin Jiang, Zhanzheng Zhao
BACKGROUND: Studies have reported that pharmacologic interventions with candesartan or ramipril could reduce the risk of hypertension among prehypertensive subjects free of clinical cardiovascular disease (CVD), however, the cost-effectiveness and long-term cardiovascular risk of drug treatment among these population is unclear. METHOD: A Markov state-transition model was developed to simulate a hypothetical cohort of Chinese adults with high-range prehypertension (130-139/85-89mmHg) but without CVD...
May 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28499988/melanocortin-neurons-multiple-routes-to-regulation-of-metabolism
#11
REVIEW
Wen-Jie Shen, Ting Yao, Xingxing Kong, Kevin W Williams, Tiemin Liu
The burden of disability, premature death, escalating health care costs and lost economic productivity due to obesity and its associated complications including hypertension, stroke, cardiovascular disease and type 2 diabetes is staggering [1, 2]. A better understanding of metabolic homeostatic pathways will provide us with insights into the biological mechanisms of obesity and how to fundamentally address this epidemic [3-6]. In mammals, energy balance is maintained via a homeostatic system involving both peripheral and central melanocortin systems; changes in body weight reflect an unbalance of the energetic state [7-9]...
May 9, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28498815/the-optimization-of-cell-therapy-by-combinational-application-with-apicidin-treated-mesenchymal-stem-cells-after-myocardial-infarction
#12
Dong Im Cho, Wan Seok Kang, Moon Hwa Hong, Hye Jin Kang, Mi Ra Kim, Min Chul Kim, Yong Sook Kim, Youngkeun Ahn
Although mesenchymal stem cells (MSC) have been shown to be safe in preclinical studies of cardiovascular disease, multiple meta-analyses have debated whether functional improvement is significant or not. The cardiac differentiation from MSC is achievable using cardiogenic factors, however, the high cost and long culture period may limit the applications. Here, we developed a novel method to optimize the therapeutic outcome for myocardial infarction (MI). Treatment of MSC with apicidin, a histone deacetylase inhibitor, dramatically increased the expressions of cardiac markers such as GATA4, Nkx2...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28495342/a-method-for-cohort-selection-of-cardiovascular-disease-records-from-an-electronic-health-record-system
#13
Maria Tereza Fernandes Abrahão, Moacyr Roberto Cuce Nobre, Marco Antonio Gutierrez
INTRODUCTION: An electronic healthcare record (EHR) system, when used by healthcare providers, improves the quality of care for patients and helps to lower costs. Information collected from manual or electronic health records can also be used for purposes not directly related to patient care delivery, in which case it is termed secondary use. EHR systems facilitate the collection of this secondary use data, which can be used for research purposes like observational studies, taking advantage of improvement in the structuring and retrieval of patient information...
June 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28494372/separation-and-preconcentration-of-riboflavin-from-human-plasma-using-polythionine-coated-magnetite-hydroxyapatite-nanocomposite-prior-to-analysis-by-surfactant-enhanced-fluorimetry
#14
Leila Farzin, Mojtaba Shamsipur
The exploration of novel adsorption properties of conductive polymers based on hybridization with biocompatible nanomaterials receives an increasing interest. In this regard, hydroxyapatite (HA) bioceramic is of critical importance mainly owing to its facile synthesis, high surface area, economic and low toxicity in biological environments. In this work, we first prepared and characterized a magnetite/hydroxyapatite (Fe3O4/HA) nanocomposite using the bio-waste chicken eggshell via an attractive green way that involved low cost and irrespective of toxicity...
May 2, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28492770/descriptive-study-on-the-evolution-of-hospitalization-costs-for-ambulatory-care-sensitive-conditions-in-brazil-2000-2013
#15
Dayane Kelle de Souza, Sérgio Viana Peixoto
OBJECTIVE: to analyze the proportions of costs of hospitalizations for ambulatory care sensitive conditions (ACSC) in relation to total hospitalization costs funded by the Brazilian National Health System (SUS) in Brazil, in 2000, 2005, 2010 and 2013, according to sex, age and group of causes. METHODS: this is a descriptive study, with data from SUS Hospital Information System (SIH/SUS); the proportion of hospitalization costs for ACSC was estimated in relation to total hospitalization costs...
April 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/28490967/comparative-study-of-fatty-acid-composition-of-table-eggs-from-the-jeddah-food-market-and-effect-of-value-addition-in-omega-3-bio-fortified-eggs
#16
Shahida Aziz Khan, Aziz Khan, Sarah A Khan, Mohd Amin Beg, Ashraf Ali, Ghazi Damanhouri
Health consciousness has increased the desire of people around the world to consume functional foods. Omega-3 essential fatty acids are one among these beneficial and important health supplements without which a general predisposition to degenerative and stress related disorders can occur. Saudi Arabia has shown an alarming increase in obesity (Al-Nozha et al., 2005), diabetes (Alqurashi et al., 2011), and cardiovascular disease (Al-Nozha et al., 2004) in the last few decades mainly due to nutritional transitions and lifestyle alterations (Amuna and Zotor, 2008)...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28490620/physical-activity-evaluation-in-children-with-congenital-heart-disease
#17
REVIEW
Christine Voss, Kevin C Harris
Significant advances in the management of children with congenital heart disease (CHD) have resulted in marked improvements in survival and life expectancy. Thus, there is an increased emphasis on promoting physical activity to optimise healthy development and long-term cardiovascular health. Evaluation of physical activity levels as part of ongoing clinical care is recommended to facilitate physical activity counselling and/or exercise prescription. Physical activity is a complex health behaviour that is challenging to evaluate...
May 10, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28490271/validation-of-a-cardiovascular-disease-policy-micro-simulation-model-using-both-survival-and-receiver-operating-characteristic-curves
#18
Ankur Pandya, Stephen Sy, Sylvia Cho, Sartaj Alam, Milton C Weinstein, Thomas A Gaziano
BACKGROUND: Despite some advances, cardiovascular disease (CVD) remains the leading cause of death and healthcare costs in the United States. We therefore developed a comprehensive CVD policy simulation model that identifies cost-effective approaches for reducing CVD burden. This paper aims to: 1) describe our model in detail; and 2) perform model validation analyses. METHODS: The model simulates 1,000,000 adults (ages 35 to 80 years) using a variety of CVD-related epidemiological data, including previously calibrated Framingham-based risk scores for coronary heart disease and stroke...
May 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28489179/analysis-of-economic-impact-between-the-modality-of-renal-replacement-therapy
#19
Denise Sbrissia E Silva Gouveia, Alexandre Tortoza Bignelli, Silvia Regina Hokazono, Itamara Danucalov, Tobias August Siemens, Fernando Meyer, Luiz Sergio Santos, Ziliane Caetano Lopes Martins, Tiago César Mierzwa, Raquel Furquim
Introduction: Chronic kidney disease (CKD) is a major health problem, determining the reduction in life expectancy and an increased risk of cardiovascular disease. Method: An observational, cohort, retrospective, based on patient's medical records data with CKD under hemodialysis, peritoneal dialysis and kidney transplantation in the city of Curitiba, in the period from January to June 2014, evacuativo the financial impact on the Unified Health System (SUS) and the supplementary health...
April 27, 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28488237/perioperative-bleeding-and-thrombotic-risks-in-patients-with-von-willebrand-disease
#20
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, Sripal Bangalore, Jeffrey S Berger
Von Willebrand disease (VWD) is an inherited bleeding disorder that often manifests clinically with hemorrhage after invasive procedures. We investigated the association between a diagnosis of VWD and bleeding and thrombotic outcomes following major non-cardiac surgery in a large national database from the United States. Patients age ≥45 years requiring major non-cardiac surgery were identified from Healthcare Cost and Utilization Project's National Inpatient Sample data. Von Willebrand disease, perioperative major adverse cardiovascular events (MACE), thrombotic events, and hemorrhage were defined by ICD9 diagnosis codes...
May 9, 2017: Journal of Thrombosis and Thrombolysis
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