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https://www.readbyqxmd.com/read/28645260/within-class-differences-in-cancer-risk-for-sulfonylurea-treatments-in-patients-with-type-2-diabetes-zodiac-55-a-study-protocol
#1
Dennis Schrijnders, Geertruida H de Bock, Sebastiaan T Houweling, Kornelis J J van Hateren, Klaas H Groenier, Jeffrey A Johnson, Henk J G Bilo, Nanne Kleefstra, Gijs W D Landman
BACKGROUND: Patients with type 2 diabetes (T2D) are at increased risk for developing cancer. As approximately 8% of the world's population is living with T2D, even a slight increase in cancer risk could result in an enormous impact on the number of persons developing cancer. In addition, several glucose lowering drug classes for treating patients with T2D have been associated with a difference in risk of cancer overall, and especially for obesity related cancers. In what way and to what degree cancer risk is modified by the use of different sulfonylureas (SU) is unclear...
June 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28644095/impact-of-adherence-to-antidepressants-on-healthcare-outcomes-and-costs-among-patients-with-type-2-diabetes-and-comorbid-major-depressive-disorder
#2
Charles Vega, Russell V Becker, Lisa Mucha, Betty H Lorenz, Michael T Eaddy, Augustina O Ogbonnaya
OBJECTIVE: To evaluate the association between adherence to antidepressants and an effect on clinical outcomes and healthcare costs in patients with major depressive disorder (MDD) and comorbid type 2 diabetes (T2D). METHODS: This retrospective study used MarketScan claims data from January 2012 to March 2014. Study entry was the first claim for an antidepressant and a diagnosis code for MDD and T2D in the prior 6 months. Adherence and persistence to antidepressant therapy in the first 180 days were defined as medication possession ratio (MPR) ≥80% and length of therapy (LOT), with no treatment gap of >15 days, respectively...
June 23, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28642211/the-integrating-depression-and-diabetes-treatment-independent-study-design-and-methods-to-address-mental-healthcare-gaps-in-india
#3
A J Kowalski, S Poongothai, L Chwastiak, M Hutcheson, N Tandon, R Khadgawat, G R Sridhar, S R Aravind, B Sosale, R M Anjana, D Rao, R Sagar, N Mehta, K M V Narayan, J Unutzer, W Katon, V Mohan, M K Ali
INTRODUCTION: Depression and diabetes are highly prevalent worldwide and often co-exist, worsening outcomes for each condition. Barriers to diagnosis and treatment are exacerbated in low and middle-income countries with limited health infrastructure and access to mental health treatment. The INtegrating DEPrEssioN and Diabetes treatmENT (INDEPENDENT) study tests the sustained effectiveness and cost-effectiveness of a multi-component care model for individuals with poorly-controlled diabetes and depression in diabetes clinics in India...
June 19, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28630653/outcomes-associated-with-pharmacist-led-diabetes-collaborative-drug-therapy-management-in-a-medicaid-population
#4
Eman Biltaji, Minkyoung Yoo, Brandon T Jennings, Jennifer P Leiser, Carrie McAdam-Marx
OBJECTIVES: Pharmacist-led diabetes collaborative drug therapy management (CDTM) has been shown to improve outcomes. Whether such programs are effective specifically in Medicaid patients, who face barriers to access and self-management, has not been well characterized. This pilot study explores glycemic control, utilization and costs associated with pharmacist-led CDTM in a small population of Medicaid patients with type 2 diabetes mellitus (T2DM). METHODS: A pre-post, historical cohort study was conducted of patients with T2DM and Medicaid coverage who received pharmacist-led CDTM in community-based primary clinics between 2008-2012...
March 2017: Journal of Pharmaceutical Health Services Research
https://www.readbyqxmd.com/read/28621283/assessment-of-levels-of-glycosylated-hemoglobin-in-patients-with-periodontal-pathologies-a-comparative-study
#5
Saurabh Wahi, Alok Tripathi, Shradha Wahi, Vikas D Mishra, Abhishek P Singh, Nikhil Sinha
INTRODUCTION: One of the potential sources for the occurrence of various systemic pathologies, such as cardiovascular diseases, cerebrovascular diseases, and respiratory diseases is periodontitis. Testing of glycosylated hemoglobin (HbA) is a highly standardized procedure and is becoming increasingly popular these days due to its cost-effectiveness and ease of use. Literature quotes numerous studies associating the peri-odontal diseases with various hemoglobin markers in diabetic and nondiabetic patients...
June 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28611921/adherence-of-self-monitoring-of-blood-glucose-in-persons-with-type-1-diabetes-in-sweden
#6
Peter Moström, Elsa Ahlén, Henrik Imberg, Per-Olof Hansson, Marcus Lind
OBJECTIVE: The primary aim was to evaluate the extent to which persons with type 1 diabetes perform self-monitoring of blood glucose (SMBG) according to guidelines. Secondary objectives were to investigate predictors for good SMBG adherence, reasons for non-adherence, and association between SMBG frequency and hemoglobin A1c (HbA1c). METHODS: This was a survey-based cross-sectional study. Questionnaires were sent out to 600 random patients at five sites. Patients were included if they were diagnosed with type 1 diabetes and ≥18 years old and excluded if they were currently using continuous glucose monitoring (CGM)...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28611672/telemedicine-for-the-management-of-glycemic-control-and-clinical-outcomes-of-type-1-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-randomized-controlled-studies
#7
REVIEW
Shaun W H Lee, Leanne Ooi, Yin K Lai
Importance: Telemedicine has been shown to be an efficient and effective means of providing care to patients with chronic disease especially in remote and undeserved regions, by improving access to care and reduce healthcare cost. However, the evidence surrounding its applicability in type 1 diabetes remains scarce and conflicting. Objective: To synthesize evidence and quantify the effectiveness of telemedicine interventions for the management of glycemic and clinical outcomes in type 1 diabetes patients, relative to comparator conditions...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28600309/dulce-digital-an-mhealth-sms-based-intervention-improves-glycemic-control-in-hispanics-with-type-2-diabetes
#8
Addie L Fortmann, Linda C Gallo, Maria Isabel Garcia, Mariam Taleb, Johanna A Euyoque, Taylor Clark, Jessica Skidmore, Monica Ruiz, Sapna Dharkar-Surber, James Schultz, Athena Philis-Tsimikas
OBJECTIVE: Type 2 diabetes is growing in epidemic proportions and disproportionately affects lower income, diverse communities. Text messaging may provide one of the most rapid methods to overcome the "digital divide" to improve care. RESEARCH DESIGN AND METHODS: A randomized, nonblinded, parallel-groups clinical trial design allocated N = 126 low-income, Hispanic participants with poorly controlled type 2 diabetes to receive the Dulce Digital intervention or usual care (UC)...
June 9, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28584822/diabetes-management-with-a-care-coordinator-improves-glucose-control-in-african-americans-and-hispanics
#9
Wayne S Rawlins, Michele A Toscano-Garand, Garth Graham
BACKGROUND: The purpose of this study was to evaluate diabetes control, as measured by hemoglobin A1c (HbA1c) improvements among African American and Hispanic patients receiving conventional clinical treatment combined with a bilingual diabetes educator using culturally and linguistically appropriate educational materials. This study also sought to estimate the healthcare cost savings resulting from any A1c improvements and assess the cost-effectiveness of this approach. MATERIALS AND METHODS: This was a multistage, face-to-face observational study undertaken in Texas, United States and focused on 153 African American and Hispanic patients with poor blood glucose control (baseline A1c >8...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28581207/improving-postprandial-hyperglycemia-in-patients-with-type-2-diabetes-already-on-basal-insulin-therapy-a-review-of-current-strategies
#10
REVIEW
Guillermo E Umpierrez, Timothy S Bailey, Danielle Carcia, Charles Shaefer, Jay H Shubrook, Neil Skolnik
A large number of patients with type 2 diabetes (T2D) on basal insulin do not reach their glycosylated hemoglobin A1c (HbA1c) goals and require additional therapy to address postprandial hyperglycemia. Guidelines from expert bodies have outlined several approaches to accomplish post-prandial glucose (PPG) control, and recent literature suggests several more. This article provides strategies for primary care physicians caring for patients with T2D who do not achieve glycemic control with basal insulin alone...
June 5, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28577364/factors-associated-with-impaired-color-vision-without-retinopathy-amongst-people-with-type-2-diabetes-mellitus-a-cross-sectional-study
#11
N C Tan, W F Yip, S Kallakuri, U Sankari, Y L E Koh
BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) may develop color vision impairment. This study aimed to determine the prevalence and factors associated with impaired color vision in patients with T2DM but without diabetic retinopathy. METHODS: Enrolment criteria included multi-ethnic Asian participants, age 21 to 80 years, with known T2DM for a minimum of 2 years. Their diagnoses were affirmed from oral glucose tolerance test results and they were screened for impaired color vision using the Farnsworth D-15 instrument...
June 2, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28572883/impact-of-creatinine-methodology-on-glomerular-filtration-rate-estimation-in-diabetes
#12
Marijana Vučić Lovrenčić, Vanja Radišić Biljak, Kristina Blaslov, Sandra Božičević, Lea Smirčić Duvnjak
AIM: To evaluate the influence of creatinine methodology on the performance of chronic kidney disease (CKD)-Epidemiology Collaboration Group-calculated estimated glomerular filtration rate (CKD-EPI-eGFR) for CKD diagnosis/staging in a large cohort of diabetic patients. METHODS: Fasting blood samples were taken from diabetic patients attending our clinic for their regular annual examination, including laboratory measurement of serum creatinine and eGFR. RESULTS: Our results indicated an overall excellent agreement in CKD staging (kappa = 0...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28551774/continuous-glucose-monitoring-for-patients-with-type-1-diabetes-on-multiple-daily-injections-of-insulin-pros-and-cons
#13
Maria Ida Maiorino, Michela Petrizzo, Giuseppe Bellastella, Katherine Esposito
Continuous glucose monitoring associated with intensive insulin regimens represents a useful tool to lower HbA1c in selected adults with type 1 diabetes. Recent randomized controlled trials demonstrated greater glycemic benefits in type 1 diabetic patients treated with multiple daily injections of insulin and continuous glucose monitoring over usual care. These positive outcomes, however, are counter-balanced by several limitations that restrict the use of continuous glucose monitoring in the real life, including the apparent lack of benefits in children and pregnant diabetic women, the high cost, the stringent patients' selection, and the presence of a multi-disciplinary team with specific expertise...
May 27, 2017: Endocrine
https://www.readbyqxmd.com/read/28551481/clinical-applicability-and-cost-effectiveness-of-diabscore-in-screening-for-type-2-diabetes-in-primary-care
#14
María Cristo Rodríguez-Pérez, Domingo Orozco-Beltrán, Vicente Gil-Guillén, Santiago Domínguez-Coello, Delia Almeida-González, Buenaventura Brito-Díaz, Itahisa Marcelino-Rodríguez, María Concepción Carratalá-Munuera, Nieves Gómez-Moreno, Jorge Navarro-Perez, Francisco Brotons-Munto, Salvador Pertusa-Martinez, Antonio Cabrera de León
AIMS: To evaluate the applicability and cost-effectiveness of a clinical risk score (DIABSCORE) to screen for type 2 diabetes in primary care patients. METHODS: Multicenter cross-sectional study of 10,508 adult no previously diagnosed with diabetes, in 2 Spanish regions (Canary Islands and Valencian Community). The variables comprising DIABSCORE were age, waist to height ratio, family history of diabetes and gestational diabetes. ROC curves were obtained; the diabetes prevalences odds ratios (HbA1c ≥6...
May 12, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28544081/direct-medical-costs-of-severe-hypoglycaemic-events-in-patients-with-type-2-diabetes-in-england-a-retrospective-database-study
#15
Tim Holbrook, Yuexin Tang, Romita Das, R Ravi Shankar, Kaan Tunceli, Jean Williams, Larry Radican, Sarah E Holden, Chris Ll Morgan, James Piercy, Craig J Currie
AIMS: Hypoglycaemia in patients with diabetes can be induced by insulins and sulfonylureas. We assessed the real-world impact of specific monotherapy and combination regimens on hypoglycaemic events requiring hospitalisation and related secondary costs to the English healthcare system. METHODS: This retrospective observational study used the Clinical Practice Research Datalink with linked hospital admission data during 2008-2012. Patients with type 2 diabetes mellitus (T2DM) using antihyperglycaemic agents (AHAs) were assigned to mutually exclusive subgroups (insulin- and non-insulin-containing regimens; treatment groups of interest; age group) based on treatment at index date (date of first AHA prescription)...
May 23, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28541132/how-can-we-realize-the-clinical-benefits-of-continuous-glucose-monitoring
#16
Ramzi A Ajjan
Controlling glycemia in diabetes remains key to prevent complications in this condition. However, glucose levels can undergo large fluctuations secondary to daily activities, consequently creating management difficulties. The current review summarizes the basics of glucose management in diabetes by addressing the main glycemic parameters. The advantages and limitation of HbA1c, the gold standard measure of glucose control, are discussed together with the clinical importance of hypoglycemia and glycemic variability...
May 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28531992/boronate-functionalized-hydrogel-as-a-novel-biosensing-interface-for-the-glycated-hemoglobin-a1c-hba1c-based-on-the-competitive-binding-with-signaling-glycoprotein
#17
Yong Duk Han, Ka Ram Kim, Yoo Min Park, Seung Yeon Song, Yong Ju Yang, Kangsun Lee, Yunhee Ku, Hyun C Yoon
According to recent increases in public healthcare costs associated with diabetes mellitus, the development of new glycemic monitoring techniques based on the biosensing of glycated hemoglobin A1c (HbA1c), a promising long-term glycemic biomarker, has become a major challenge. In the development of HbA1c biosensors for point-of-care applications, the selection of an effective biorecognition layer that provides a high reaction yield and specificity toward HbA1c is regarded as the most significant issue. To address this, we developed a novel HbA1c biosensing interfacial material by the integration of boronate hydrogel with glass fiber membrane...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28523483/modeling-the-long-term-cost-effectiveness-of-ideglira-in-patients-with-type-2-diabetes-who-are-failing-to-meet-glycemic-targets-on-basal-insulin-alone-in-the-netherlands
#18
Barnaby Hunt, Divina Glah, Maarten van der Vliet
INTRODUCTION: Insulin degludec/liraglutide (IDegLira) is the first basal insulin and glucagon-like peptide-1 receptor agonist (GLP-1 RA) in a single pen injection device, and a once-daily treatment option for patients with type 2 diabetes mellitus (T2DM) who are uncontrolled on basal insulin and require treatment intensification. The objective of this analysis was to evaluate the long-term cost-effectiveness of IDegLira versus basal-bolus therapy (insulin glargine U100 + 3× daily insulin aspart) for patients with T2DM uncontrolled on basal insulin [HbA1c >53 mmol/mol (>7%)] in the Netherlands...
May 18, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28512629/a-modified-behavior-risk-factor-surveillance-system-to-assess-diabetes-self-management-behaviors-and-diabetes-care-in-monterrey-mexico-a-cross-sectional-study
#19
Marylyn Morris McEwen, Rogelio Andrès Elizondo-Pereo, Alice E Pasvogel, Irene Meester, Javier Vargas-Villarreal, Francisco González-Salazar
Type 2 diabetes mellitus (T2DM) is one of the leading causes of death from worldwide non-communicable diseases. The prevalence of diabetes in the Mexico (MX)-United States border states exceeds the national rate in both countries. The economic burden of diabetes, due to decreased productivity, disability, and medical costs, is staggering and increases significantly when T2DM-related complications occur. The purpose of this study was to use a modified behavioral risk factor surveillance system (BRFSS) to describe the T2DM self-management behaviors, diabetes care, and health perception of a convenience sample of adults with T2DM in Monterrey, MX...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28500868/type-1-diabetes-mellitus-care-and-education-in-china-the-3c-study-of-coverage-cost-and-care-in-beijing-and-shantou
#20
Helen C McGuire, Linong Ji, Katarzyna Kissimova-Skarbek, David Whiting, Florencia Aguirre, Puhong Zhang, Shaoda Lin, Chunxiu Gong, Weigang Zhao, Juming Lu, Xiaohui Guo, Ying Ji, Till Seuring, Tianpei Hong, Lishu Chen, Jianping Weng, Zhiguang Zhou
AIMS: The paucity of data on Type 1 diabetes in China hinders progress in care and policy-making. This study compares Type 1 diabetes care and clinical outcomes in Beijing and Shantou with current clinical guidelines. METHODS: The 3C Study was a cross-sectional study of the clinical practices and outcomes of people with Type 1 diabetes. The study sequentially enrolled 849 participants from hospital records, inpatient wards, and outpatient clinics. Data were collected via face-to-face interviews with patients and health professionals, the Summary of Diabetes Self-Care Activities, medical records, and venous blood samples...
July 2017: Diabetes Research and Clinical Practice
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