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https://www.readbyqxmd.com/read/29327112/simultaneous-pre-concentration-and-separation-on-simple-paper-based-analytical-device-for-protein-analysis
#1
Ji-Cheng Niu, Ting Zhou, Li-Li Niu, Zhen-Sheng Xie, Fang Fang, Fu-Quan Yang, Zhi-Yong Wu
In this work, fast isoelectric focusing (IEF) was successfully implemented on an open paper fluidic channel for simultaneous concentration and separation of proteins from complex matrix. With this simple device, IEF can be finished in 10 min with a resolution of 0.03 pH units and concentration factor of 10, as estimated by color model proteins by smartphone-based colorimetric detection. Fast detection of albumin from human serum and glycated hemoglobin (HBA1c) from blood cell was demonstrated. In addition, off-line identification of the model proteins from the IEF fractions with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) was also shown...
January 11, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29302549/validity-of-indian-diabetes-risk-score-and-its-association-with-body-mass-index-and-glycosylated-hemoglobin-for-screening-of-diabetes-in-and-around-areas-of-lucknow
#2
Mohammad Mustufa Khan, Gyanendra Kumar Sonkar, Roshan Alam, Sudhir Mehrotra, M Salman Khan, Ajay Kumar, Satyendra Kumar Sonkar
Objectives: The present study aimed to assess the validity of Indian Diabetes Risk Score (IDRS) and its association with body mass index (BMI) and glycosylated hemoglobin (HbA1c) for screening of diabetes and obesity. Methodology: A cross-sectional study was designed, and samples were randomly enrolled from Lucknow and its adjoining areas. Totally, 405 subjects were included in the study. We used diabetes risk factors (age, waist circumference, physical activity, and family history of diabetes) for screening of diabetes and abdominal obesity (AO) and BMI for screening of general obesity...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29302542/compliance-to-treatment-among-type-2-diabetics-receiving-care-at-peripheral-mobile-clinics-in-a-rural-block-of-vellore-district-southern-india
#3
Divya Elizabeth Muliyil, Kanagalakshmi Vellaiputhiyavan, Reginald Alex, Venkata Raghava Mohan
Background: Providing treatment to patients with diabetes mellitus in rural areas at a cost they can afford is a public health challenge. Aims: This study aims to measure the rate of compliance to oral hypoglycemic agents among patients with type 2 diabetes mellitus attending peripheral mobile clinics in rural South India. To study factors that impact glycemic control. Setting and Design: A cross-sectional study was done among patients attending peripheral mobile clinics in a rural block in Southern India...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29277099/financial-incentives-for-medicaid-beneficiaries-with-diabetes-lessons-learned-from-hi-praise-an-observational-study-and-randomized-controlled-trial
#4
Ritabelle Fernandes, Chuan C Chinn, Dongmei Li, Timothy Halliday, Timothy B Frankland, Christina M B Wang, Zi Wang, Misha Morioka, Robin G Arndt, Rebecca Rude Ozaki
PURPOSE: The Hawaii Patient Reward and Incentives to Support Empowerment (HI-PRAISE) project examined the impact of financial incentives on Medicaid beneficiaries with diabetes. DESIGN: Observational pre-post study and randomized controlled trial (RCT). SETTING: Federally qualified health centers (FQHCs) and Hawaii Kaiser Permanente. PARTICIPANTS: The observational study included 2003 Medicaid beneficiaries with diabetes from FQHCs...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29275488/the-renoprotective-effect-and-safety-of-a-dpp-4-inhibitor-sitagliptin-at-a-small-dose-in-type-2-diabetic-patients-with-a-renal-dysfunction-when-changed-from-other-dpp-4-inhibitors-real-trial
#5
Koichi Kanozawa, Yuichi Noguchi, Souichi Sugahara, Satoko Nakamura, Hirohisa Yamamoto, Keiko Kaneko, Rika Kono, Saeko Sato, Tomonari Ogawa, Hajime Hasegawa, Shigehiro Katayama
BACKGROUND: We conducted the multicenter, prospective, open-label study in type 2 diabetic (T2DM) patients with renal dysfunction, to clarify the efficacy and the safety in relation to renal function and glycemic control, and the economic effect when other dipeptidyl peptidase-4 (DPP-4) inhibitors were switched to a small dose of sitagliptin depending on their renal function. METHODS: Vildagliptin, alogliptin, or linagliptin received for more than 2 months were changed to sitagliptin at 25 or 12...
December 23, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29261739/relation-between-cost-of-drug-treatment-and-body-mass-index-in-people-with-type-2-diabetes-in-latin-america
#6
Jorge Federico Elgart, Mariana Prestes, Lorena Gonzalez, Enzo Rucci, Juan Jose Gagliardino
AIMS: Despite the frequent association of obesity with type 2 diabetes (T2D), the effect of the former on the cost of drug treatment of the latest has not been specifically addressed. We studied the association of overweight/obesity on the cost of drug treatment of hyperglycemia, hypertension and dyslipidemia in a population with T2D. METHODS: This observational study utilized data from the QUALIDIAB database on 3,099 T2D patients seen in Diabetes Centers in Argentina, Chile, Colombia, Peru, and Venezuela...
2017: PloS One
https://www.readbyqxmd.com/read/29260924/pharmacokinetic-drug-evaluation-of-exenatide-for-the-treatment-of-type-2-diabetes
#7
María Molina Vega, Araceli Muñoz-Garach, Francisco J Tinahones
INTRODUCTION: Glucagon-like peptide-1 (GLP-1) receptor analogs are a group of therapeutic agents which mimic endogenous GLP-1, exerting their effect by the stimulation of the GLP-1 receptor with a wide distribution. Its activation increases insulin releasing dependent on blood glucose levels, suppression of glucagon secretion and a reduction of hepatic glucose output. It delays gastric emptying and increases satiety. Exenatide is the synthetic version of exendin-4, a natural peptide with similar properties to human GLP-1...
December 20, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29230472/individualized-glycemic-control-for-u-s-adults-with-type-2-diabetes-a-cost-effectiveness-analysis
#8
Neda Laiteerapong, Jennifer M Cooper, M Reza Skandari, Philip M Clarke, Aaron N Winn, Rochelle N Naylor, Elbert S Huang
Background: Intensive glycemic control in type 2 diabetes (glycated hemoglobin [HbA1c] level <7%) is an established, cost-effective standard of care. However, guidelines recommend individualizing goals on the basis of age, comorbidity, diabetes duration, and complications. Objective: To estimate the cost-effectiveness of individualized control versus uniform intensive control (HbA1c level <7%) for the U.S. population with type 2 diabetes. Design: Patient-level Monte Carlo-based Markov model...
December 12, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29225890/can-peer-support-be-cost-saving-an-economic-evaluation-of-rapsid-a-randomized-controlled-trial-of-peer-support-in-diabetes-compared-to-usual-care-alone-in-east-of-england-communities
#9
La'Marcus Wingate, Jonathan Graffy, Daniel Holman, David Simmons
Background: Diabetes peer support, where one person with diabetes helps others, may improve diabetes management. The objective of this study was to perform a cost analysis of peer support strategies used in RAndomized controlled trial of Peer Support in type 2 Diabetes. Methods: We performed a 2×2 factorial randomized cluster controlled trial in England. People with type 2 diabetes were invited to participate as either 'peer' or 'peer support facilitator' (PSF) through postal invitation predominantly from general practice...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29218959/self-efficacy-depression-and-self-care-activities-of-people-with-type-2-diabetes-in-turkey
#10
Sultan Kav, Arzu Akman Yilmaz, Yasemin Bulut, Nevin Dogan
Background: Self-efficacy related to self-care behaviors in people with type 2 diabetes has been well reported. However no work has been reported in Turkey that uses reliable instruments to examine the relationships among self-care activities, depression and self-efficacy. Aim: This study aims to investigate self-care activities, depression and self-efficacy among people with type 2 diabetes in Turkey. Methods: The sample included 200 patients with type 2 diabetes from an endocrinology outpatient clinic at a university hospital...
2017: Collegian: Journal of the Royal College of Nursing, Australia
https://www.readbyqxmd.com/read/29209814/teleconsultation-in-type-1-diabetes-mellitus-telediabe
#11
Federico Bertuzzi, Ilario Stefani, Benedetta Rivolta, Basilio Pintaudi, Elena Meneghini, Livio Luzi, Antonino Mazzone
AIMS: The growing incidence of diabetes and the need to contain healthcare costs empower the necessity to identify new models of care. Telemedicine offers an acknowledged instrument to provide clinical health care at a distance, increasing patient compliance and the achievement of therapeutical goals. The objective was to test the feasibility and the efficacy in the improvement of the glycemic control of the teleconsultation for patients with type 1 diabetes mellitus. METHODS: A randomized open-label, parallel arms, controlled trial was conducted in two diabetes centers in Italy...
December 5, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29204855/achieving-good-glycemic-control-early-after-onset-of-diabetes-a-cost-effectiveness-analysis-in-patients-with-type-1-diabetes-in-sweden
#12
Johan Jendle, Åsa Ericsson, Barnaby Hunt, William J Valentine, Richard F Pollock
INTRODUCTION: Sweden has amongst the highest incidence rates of type 1 diabetes (T1D) in Europe. The high incidence and chronic nature of T1D result in high prevalence and economic burden. Improving glycemic control reduces the incidence of microvascular complications, which in turn reduces medical costs. The present study aimed to quantify the reductions in cost and improvements in quality-adjusted life expectancy with varying reductions in HbA1c in the T1D population. METHODS: The IQVIA CORE Diabetes Model was used to simulate a typical Swedish population of patients with T1D experiencing HbA1c reductions from 0...
December 4, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29199404/improvement-of-glycosylated-hemoglobin-in-patients-with-type-2-diabetes-mellitus-under-insulin-treatment-by-reimbursement-for-self-monitoring-of-blood-glucose
#13
Young Shin Song, Bo Kyung Koo, Sang Wan Kim, Ka Hee Yi, Kichul Shin, Min Kyong Moon
BACKGROUND: In Korea, the costs associated with self-monitoring of blood glucose (SMBG) for patients with type 2 diabetes mellitus (T2DM) under insulin treatment have been reimbursed since November 2015. We investigated whether this new reimbursement program for SMBG has improved the glycemic control in the beneficiaries of this policy. METHODS: Among all adult T2DM patients with ≥3 months of reimbursement (n=854), subjects without any changes in anti-hyperglycemic agents during the study period were selected...
September 28, 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29198666/the-pancreas-can-take-the-cold-lower-waitlist-times-through-importation
#14
K Choinski, J P Rocca, J Torabi, K Lorenzen, C Yongue, M E Herbert, T Block, A Chokechanachaisakul, L Kamal, M Kinkhabwala, J A Graham
BACKGROUND: Our center has used a strategy of pancreas importation owing to long regional waitlist times. Here we assess the clinical outcomes and financial considerations of this strategy. METHODS: This was a retrospective observational cohort study of patients who received a pancreas transplant at Montefiore Medical Center (MMC) from 2014 to 2017 (n = 28). Clinical parameters, including hemoglobin A1c and complications, were analyzed. The cohort was compared with United Network for Organ Sharing (UNOS) Region 9 with the use of the UNOS/Organ Procurement and Transplantation Network database...
December 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29164512/individuals-with-type-1-and-type-2-diabetes-mellitus-trade-increased-hyperglycemia-for-decreased-hypoglycemia-when-glycemic-variability-is-not-improved
#15
Sujit R Jangam, Gary Hayter, Timothy C Dunn
INTRODUCTION: Glycemic variability refers to oscillations in blood glucose within a day and differences in blood glucose at the same time on different days. Glycemic variability is linked to hypoglycemia and hyperglycemia. The relationship among these three important metrics is examined here, specifically to show how reduction in both hypo- and hyperglycemia risk is dependent on changes in variability. METHODS: To understand the importance of glycemic variability in the simultaneous reduction of hypoglycemia and hyperglycemia risk, we introduce the glycemic risk plot-estimated HbA1c % (eA1c) vs...
November 21, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29161972/impacts-of-initial-transformation-to-a-patient-centered-medical-home-on-diabetes-outcomes-in-federally-qualified-health-centers-in-florida
#16
Heidi S Kinsell, Allyson G Hall, Jeffrey S Harman, Sweta Tewary, Andrew Brickman
OBJECTIVE: Federally qualified health centers (FQHCs) in Florida see large numbers of vulnerable patients with diabetes. Patient-centered medical home (PCMH) models can lead to improvements in health for patients with chronic conditions and cost savings for providers. Therefore, FQHCs are increasingly moving to PCMH models of care. The study objective was to examine the effects of initial transformation to a level 3 National Committee for Quality Assurance (NCQA) certified PCMH in 2011, on clinical diabetes outcomes among 27 clinic sites from a network of FQHCs in Florida...
November 1, 2017: Journal of Primary Care & Community Health
https://www.readbyqxmd.com/read/29149912/trial-to-incentivise-adherence-for-diabetes-triad-study-protocol-for-a-randomised-controlled-trial
#17
Marcel Bilger, Mitesh Shah, Ngiap Chuan Tan, Kaye Louise Howard, Hui Yan Xu, Ecosse Luc Lamoureux, Eric Andrew Finkelstein
BACKGROUND: Many people with diabetes have suboptimal glycaemic control due to not being adherent to their treatment regimen. Behavioural economic theory suggests that the lack of adherence results from the disconnect between the timing of when costs and benefits accrue. One strategy to address this discontinuity is to offer patients a near-term benefit, such as a financial reward. Whereas there is evidence that rewards can improve treatment adherence and sometimes health outcomes, further research is needed to determine whether rewards are more effective when targeting processes or intermediary health outcomes...
November 17, 2017: Trials
https://www.readbyqxmd.com/read/29146657/a-randomised-controlled-trial-of-a-duodenal-jejunal-bypass-sleeve-device-endobarrier-compared-with-standard-medical-therapy-for-the-management-of-obese-subjects-with-type-2-diabetes-mellitus
#18
Michael Alan Glaysher, Aruchuna Mohanaruban, Christina Gabriele Prechtl, Anthony P Goldstone, Alexander Dimitri Miras, Joanne Lord, Navpreet Chhina, Emanuela Falaschetti, Nicholas Andrew Johnson, Werd Al-Najim, Claire Smith, Jia V Li, Mayank Patel, Ahmed R Ahmed, Michael Moore, Neil Poulter, Stephen Bloom, Ara Darzi, Carel Le Roux, James P Byrne, Julian P Teare
INTRODUCTION: The prevalence of obesity and obesity-related diseases, including type 2 diabetes mellitus (T2DM), is increasing. Exclusion of the foregut, as occurs in Roux-en-Y gastric bypass, has a key role in the metabolic improvements that occur following bariatric surgery, which are independent of weight loss. Endoscopically placed duodenal-jejunal bypass sleeve devices, such as the EndoBarrier (GI Dynamics, Lexington, Massachusetts, USA), have been designed to create an impermeable barrier between chyme exiting the stomach and the mucosa of the duodenum and proximal jejunum...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29136331/risk-factor-management-in-a-contemporary-australian-population-at-increased-cardiovascular-disease-risk
#19
D J Campbell, J M Coller, F F Gong, M McGrady, D L Prior, U Boffa, L Shiel, D Liew, R Wolfe, A J Owen, H Krum, C M Reid
BACKGROUND: Effective management of cardiovascular and chronic kidney disease risk factors offers longer, healthier lives and savings in health care. We examined risk factor management in participants of the SCReening Evaluation of the Evolution of New Heart Failure (SCREEN-HF) study, a self-selected population at increased cardiovascular disease risk recruited from members of a health insurance fund in Melbourne and Shepparton, Australia. METHODS: Inclusion criteria were age ≥60 years with one or more of self-reported ischaemic or other heart disease, irregular or rapid heart rhythm, cerebrovascular disease, renal impairment, or treatment for hypertension or diabetes for ≥2 years...
November 14, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29120361/variation-in-point-of-care-testing-of-hba1c-in-diabetes-care-in-general-practice
#20
Troels Kristensen, Frans Boch Waldorff, Jørgen Nexøe, Christian Volmar Skovsgaard, Kim Rose Olsen
Background: Point-of-care testing (POCT) of HbA1c may result in improved diabetic control, better patient outcomes, and enhanced clinical efficiency with fewer patient visits and subsequent reductions in costs. In 2008, the Danish regulators created a framework agreement regarding a new fee-for-service fee for the remuneration of POCT of HbA1c in general practice. According to secondary research, only the Capital Region of Denmark has allowed GPs to use this new incentive for POCT. The aim of this study is to use patient data to characterize patients with diabetes who have received POCT of HbA1c and analyze the variation in the use of POCT of HbA1c among patients with diabetes in Danish general practice...
November 9, 2017: International Journal of Environmental Research and Public Health
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