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JOURNAL ARTICLE
Mohammad Moatz Shollar, Joumaa Merza, Maher Darwish, Mohammad Keshe
In this study, two derivatives, namely the ester derivative cinnamoyl metronidazole and the amide derivative cinnamoyl memantine, were synthesized from cinnamic acid and respective drugs for the purpose of exploring their potential as novel and efficient antimicrobial agents in the quest of prevailing the global antimicrobial resistance challenge. The synthesis process involved two steps: first, the chlorination of cinnamic acid using thionyl chloride, and second, the esterification of metronidazole or the amidation of memantine...
May 15, 2024: Heliyon
#22
RANDOMIZED CONTROLLED TRIAL
Gyuri Kim, Seohyun Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
BACKGROUND: We investigated the effects of a physical activity encouragement intervention based on a smartphone personal health record (PHR) application (app) on step count increases, glycemic control, and body weight in patients with type 2 diabetes (T2D). METHODS: In this 12-week, single-center, randomized controlled, 12-week extension study, patients with T2D who were overweight or obese were randomized using ratio 1:2 to a group using a smartphone PHR app (control group) or group using the app and received individualized motivational text messages (intervention group) for 12 weeks...
May 1, 2024: BMC Medicine
#23
JOURNAL ARTICLE
Emily J Vogel, Milagros Neyra, David A Larsen, Teng Zeng
Wastewater-based epidemiology (WBE) has been widely implemented around the world as a complementary tool to conventional surveillance techniques to inform and improve public health responses. Currently, wastewater surveillance programs in the U.S. are evaluating integrated approaches to address public health challenges across multiple domains, including substance abuse. In this work, we demonstrated the potential of online solid-phase extraction coupled with liquid chromatography-high-resolution mass spectrometry to support targeted quantification and nontargeted analysis of psychoactive and lifestyle substances as a step toward understanding the operational feasibility of a statewide wastewater surveillance program for substance use assessment in New York...
May 1, 2024: Environmental Science & Technology
#24
JOURNAL ARTICLE
Alyssa O Vanderlinden, Masood Nevisipour, Thomas Sugar, Hyunglae Lee
Older adults have a decreased trunk movement control which is linked to their higher fall risk. While motor/cognitive dual-tasking deteriorates balance and walking in older adults, there is limited understanding on how trunk kinematics and kinetics are affected by dual-tasking in scenarios where falls can occur. Therefore, the purpose of the study was to determine the impacts of a challenging motor dual-task, specifically obstacle avoidance during walking, on trunk and lower-body kinematics and kinetics of older adults compared to young adults...
April 30, 2024: Human Movement Science
#25
JOURNAL ARTICLE
Piotr H Skarzynski, Natalia Czajka, Rita Zdanowicz, Aleksandra Kolodziejak, Ewelina Bukato, Małgorzata Talarek, Zuzanna Pankowska, Henryk Skarzynski
INTRODUCTION: Central auditory processing disorders (CAPD) can significantly affect the daily functioning of a child, and the first step in determining whether rehabilitation procedures are required is a proper diagnosis. Different guidelines for making diagnoses have been published in the literature, and in various centers normative values for psychoacoustic tests of CAPD have been used internally. The material presented in this paper is based on more than 1000 children and is the largest collection so far published...
April 12, 2024: Journal of Communication Disorders
#26
JOURNAL ARTICLE
Felix Kluge, Yonatan E Brand, M Encarna Micó-Amigo, Stefano Bertuletti, Ilaria D'Ascanio, Eran Gazit, Tecla Bonci, Cameron Kirk, Arne Küderle, Luca Palmerini, Anisoara Paraschiv-Ionescu, Francesca Salis, Abolfazl Soltani, Martin Ullrich, Lisa Alcock, Kamiar Aminian, Clemens Becker, Philip Brown, Joren Buekers, Anne-Elie Carsin, Marco Caruso, Brian Caulfield, Andrea Cereatti, Lorenzo Chiari, Carlos Echevarria, Bjoern Eskofier, Jordi Evers, Judith Garcia-Aymerich, Tilo Hache, Clint Hansen, Jeffrey M Hausdorff, Hugo Hiden, Emily Hume, Alison Keogh, Sarah Koch, Walter Maetzler, Dimitrios Megaritis, Martijn Niessen, Or Perlman, Lars Schwickert, Kirsty Scott, Basil Sharrack, David Singleton, Beatrix Vereijken, Ioannis Vogiatzis, Alison Yarnall, Lynn Rochester, Claudia Mazzà, Silvia Del Din, Arne Mueller
BACKGROUND: Wrist-worn inertial sensors are used in digital health for evaluating mobility in real-world environments. Preceding the estimation of spatiotemporal gait parameters within long-term recordings, gait detection is an important step to identify regions of interest where gait occurs, which requires robust algorithms due to the complexity of arm movements. While algorithms exist for other sensor positions, a comparative validation of algorithms applied to the wrist position on real-world data sets across different disease populations is missing...
May 1, 2024: JMIR Formative Research
#27
JOURNAL ARTICLE
Arkasha Sadhewa, Lydia V Panggalo, Illene Nanine, Ric N Price, Kamala Thriemer, Ari W Satyagraha, Benedikt Ley
BACKGROUND: The WHO recommends routine testing of G6PD activity to guide radical cure in patients with Plasmodium vivax malaria. Females may have intermediate G6PD enzyme activity and to date, only complex diagnostics are able to reliably identify them. The semi-quantitative G6PD diagnostic "One Step G6PD Test" (Humasis, RoK; "RDT") is a lateral flow assay that can distinguish deficient, intermediate, and normal G6PD status and offers a simpler diagnostic alternative. METHODS: G6PD status of participants enrolled in Malinau and Nunukan Regencies and the capital Jakarta was assessed with the RDT, and G6PD activity was measured in duplicate by reference spectrophotometry...
2024: PloS One
#28
JOURNAL ARTICLE
Franziska Fink, Ivonne Kalter, Jenny-Victoria Steindorff, Hans Konrad Helmbold, Denny Paulicke, Patrick Jahn
BACKGROUND: The use of drones in the health care sector is increasingly being discussed against the background of the aging population and the growing shortage of skilled workers. In particular, the use of drones to provide medication in rural areas could bring advantages for the care of people with and without a need for care. However, there are hardly any data available that focus on the interaction between humans and drones. OBJECTIVE: This study aims to disclose and analyze factors associated with user acceptance of drone-based medication delivery to derive practice-relevant guidance points for participatory technology development (for apps and drones)...
April 30, 2024: JMIR Human Factors
#29
JOURNAL ARTICLE
Jéssica Alves Ribeiro, Felipe Barreto Schuch, Laís Tonello, Kleber F Meneghel Vargas, Silvio A Oliveira-Junior, Paulo T Müller, Daniel Boullosa
BACKGROUND: High-intensity intermittent training has emerged as an option for treating major depressive disorder (MDD). However, short sprint training (sSIT), an efficient HIIT modality, has not been tested yet for this purpose. The sSIT has been proven to induce the same metabolic adaptations, with the advantage of promoting lower muscle fatigue than other HIIT protocols. METHODS: Seventeen adult women diagnosed with moderate/severe MDD were randomly allocated into a sSIT group (n=9) or a control condition (n=8)...
2024: Frontiers in Psychiatry
#30
JOURNAL ARTICLE
Insights into designing educational materials for persons living with dementia: a focus group study.
Charity M Hoffman, Sarah E Vordenberg, Amanda N Leggett, Esther Akinyemi, Molly Turnwald, Donovan T Maust
BACKGROUND: Persons living with dementia (PLWD) may experience communication difficulties that impact their ability to process written and pictorial information. Patient-facing education may help promote discontinuation of potentially inappropriate medications for older adults without dementia, but it is unclear how to adapt this approach for PLWD. Our objective was to solicit feedback from PLWD and their care partners to gain insights into the design of PLWD-facing deprescribing intervention materials and PLWD-facing education material more broadly...
April 29, 2024: BMC Geriatrics
#31
JOURNAL ARTICLE
Chao Li, Fu-Chun Li
The aim of this study was to improve the process of microincision and endoscopic surgery for the treatment of Achilles tendon (AT) rupture using the modified minimally invasive Bunnell suture (MIBS) technique.From December 2019 to December 2021, 20 patients with AT rupture who visited the First Affiliated Hospital of Harbin Medical University (Harbin, China) underwent MIBS surgery.A total of 20 patients were included, of whom 18 (90.0%) were male and 2 (10.0%) were female. The mean age of the patients was 37...
April 29, 2024: Zeitschrift Für Orthopädie und Unfallchirurgie
#32
REVIEW
Kathryn Abell, Dorothy K Sit, Katherine L Wisner
BACKGROUND: Major depressive disorder is highly prevalent among persons with epilepsy (PWEs). Between 30% and 50% of PWEs suffer from depression. Many factors contribute to this prevalence, including the psychosocial impact of the diagnosis, restrictions on driving and certain types of work, and adverse effects associated with antiseizure medications. Without proper treatment, depressed PWEs have increased risks for suicide, strained relationships, lowered seizure control, and impairment in functioning...
May 2024: Journal of Clinical Psychopharmacology
#33
JOURNAL ARTICLE
Zerin Jannat, Hemel Das, Md Wazed Ali, Tasnuva Wahed, Md Nurul Alam, Md Jasim Uddin
BACKGROUND: Vaccination has been an indispensable step in controlling the coronavirus disease pandemic. In early 2021, Bangladesh launched a mass vaccination campaign to boost the COVID-19 vaccination rate when doses were available and immunized millions in the country. Although deemed a success, disparities became conspicuous in vaccination coverage across population of different socioeconomic background. METHODS: The purpose of this cross-sectional study was to assess the vaccination coverage for three doses and detect disparities in uptake of the COVID-19 vaccine among rural population of hard-to-reach areas and urban individuals belonging to the high-risk group -defined in our study as individuals from elusive population such as floating population/street dwellers, transgender, addicts and disabled population...
2024: PloS One
#34
JOURNAL ARTICLE
Rachel Torkington-Stokes, Kate Moran, Diego Sevilla Martinez, Deborah Cesura Granara, Daniel Gary Metcalf
OBJECTIVE: To evaluate the impact of a four-step biofilm-based wound care strategy, Wound Hygiene Protocol (WHP: cleanse, debride, refashion, and dress), on hard-to-heal wounds. METHOD: This was a prospective, real-world analysis of hard-to-heal wounds managed with the WHP that incorporated Aquacel Ag+ (Convatec Ltd., UK) dressings. Data were captured electronically between April 2021 and December 2022. The primary endpoint was change in wound volume from baseline to final assessment...
May 2, 2024: Journal of Wound Care
#35
JOURNAL ARTICLE
Alshimaa R Azab, Ragab K Elnaggar, Sobhy M Aly, Nourah Basalem, Aiyshah M Alamri, Ayman K Saleh, Mohamed N Ibrahim, Maged A Basha, Walid Kamal Abdelbasset
OBJECTIVE: Turf toe is a common sports injury that may affect mobility and functional ability. For complete recovery, rehabilitation modalities are required to overcome these issues. This study investigated whether kinesio taping (KT) would reduce pain, improve gait performance, and enhance the functional capacity of turf toe patients undergoing physical therapy. METHODS: sixty patients with grade II turf toe (age; 25-30 years) assigned randomly into three treatment groups; KT applied alongside an exercise program conducted three times/week for 12 successive weeks...
April 30, 2024: Heliyon
#36
REVIEW
Fu Lin, Liankun Sun, Yu Zhang, Weinan Gao, Zihan Chen, Yanan Liu, Kai Tian, Xuyu Han, Ruize Liu, Yang Li, Luyan Shen
Regeneration and repair are prerequisites for maintaining effective function of skeletal muscle under high energy demands, and myogenic differentiation is one of the key steps in the regeneration and repair process. A striking feature of the process of myogenic differentiation is the alteration of mitochondria in number and function. Mitochondrial dysfunction can activate a number of transcriptional, translational and post-translational programmes and pathways to maintain cellular homeostasis under different types and degrees of stress, either through its own signaling or through constant signaling interactions with the nucleus and cytoplasm, a process known as the mitochondrial stress responses (MSRs)...
2024: Frontiers in Cell and Developmental Biology
#37
JOURNAL ARTICLE
Chunhui Liu, Simona Premcheska, Andre Skirtach, Dirk Poelman, Anna M Kaczmarek, Pascal Van Der Voort
This study explores the potential of combining periodic mesoporous organosilicas (PMOs) with a fluorescent dye to develop a ratiometric thermometry system with enhanced stability, sensitivity, and biocompatibility. PMOs, ordered porous materials known for their stability and versatility, serve as an ideal platform. Curcumin, a natural polyphenol and fluorescent dye, is incorporated into PMOs to develop curcumin-functionalized PMOs (C-PMO) and curcumin-pyrazole-functionalized PMOs (CP-PMO) via hydrolysis and co-condensation...
April 25, 2024: Journal of Materials Chemistry. C, Materials for Optical and Electronic Devices
#38
JOURNAL ARTICLE
Siobhan Lawler, Emma L Barrett, Maree Teesson, Erin Kelly, Katrina E Champion, Jennifer Debenham, Anna Smout, Cath Chapman, Tim Slade, Patricia J Conrod, Nicola C Newton, Lexine Stapinski
BACKGROUND: Addressing aggressive behavior in adolescence is a key step toward preventing violence and associated social and economic costs in adulthood. This study examined the secondary effects of the personality-targeted substance use preventive program Preventure on aggressive behavior from ages 13 to 20. METHODS: In total, 339 young people from nine independent schools ( M age = 13.03 years, s.d. = 0.47, range = 12-15) who rated highly on one of the four personality traits associated with increased substance use and other emotional/behavioral symptoms (i...
April 29, 2024: Psychological Medicine
#39
COMPARATIVE STUDY
Shuqing Zhu, Mengtian Zhou, Haoyu Li, Shaodan Zhang, Shuxia Xu, Haishuang Lin, Yanqie Xie, Rongrong Le, Yuanbo Liang
BACKGROUND: Neovascular glaucoma (NVG) is an irreversible blinding eye disease worldwide and is classified as one of the refractory glaucoma conditions, severely impacting visual function and vision. Unfortunately, effective surgical interventions to improve the prognosis of NVG patients are currently lacking. The study aims to evaluate the efficacy and safety of anterior chamber proliferative membrane interception (AC-PMI)-enhanced trabeculectomy compared to the traditional trabeculectomy...
April 29, 2024: Trials
#40
JOURNAL ARTICLE
Aline Cristina Parletta, Gabriela Cavazza Cerri, Claudia Ribeiro Borba Gasparini, Karine Panico, Denival Nascimento Vieira-Junior, Larissa Maria Zacarias-Rodrigues, Nathalia Senger, Amanda de Almeida Silva, Marina Fevereiro, Gabriela Placoná Diniz, Maria Cláudia Costa Irigoyen, Maria Luiza Morais Barreto-Chaves
Cardiac hypertrophy (CH) is an adaptive response to maintain cardiac function; however, persistent stress responses lead to contractile dysfunction and heart failure. Although inflammation is involved in these processes, the mechanisms that control cardiac inflammation and hypertrophy still need to be clarified. The NLRP3 inflammasome is a cytosolic multiprotein complex that mediates IL-1β production. The priming step of NLRP3 is essential for increasing the expression of its components and occurs following NF-κB activation...
April 29, 2024: Pflügers Archiv: European Journal of Physiology
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