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https://www.readbyqxmd.com/read/29679548/the-effect-of-myelotomy-following-low-thoracic-spinal-cord-compression-injury-in-rats
#1
Carolin Meyer, Habib Bendella, Svenja Rink, Robin Gensch, Robert Seitz, Gregor Stein, Marilena Manthou, Theodora Papamitsou, Makoto Nakamura, Bertil Bouillon, Mary Galea, Peter Batchelor, Sarah Dunlop, Doychin Angelov
Myelotomy is a surgical procedure allowing removal of extravasated blood and necrotic tissue that is thought to attenuate secondary injury as well as promote recovery in experimental spinal cord injury (SCI) models and humans. Here we examined in rat whether myelotomy at 48 h after low-thoracic compressive SCI provided any benefit over a 12 week period. Compared to animals receiving SCI alone, myelotomy worsened BBB scores (p < 0.05) and also did not improve plantar stepping, ladder climbing, urinary bladder voiding or sensory function (thermal latency) during the 12-week period...
April 18, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29678994/can-exercise-delay-transition-to-active-therapy-in-men-with-low-grade-prostate-cancer-a-multicentre-randomised-controlled-trial
#2
Daniel A Galvão, Dickon Hayne, Mark Frydenberg, Suzanne K Chambers, Dennis R Taaffe, Nigel Spry, Paul A Scuffham, Robert S Ware, Nicolas H Hart, Robert U Newton
INTRODUCTION: Active surveillance is a strategy for managing low-risk, localised prostate cancer, where men are observed with serial prostate-specific antigen assessments to identify signs of disease progression. Currently, there are no strategies to support active surveillance compliance nor are there interventions that can prevent or slow disease progression, ultimately delaying transition to active treatment before it is clinically required. Recently, we proposed that exercise may have a therapeutic potential in delaying the need for active treatment in men on active surveillance...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678978/community-based-diagnosis-of-non-communicable-diseases-and-their-risk-factors-in-rural-and-urban-haiti-a-cross-sectional-prevalence-study
#3
Vincent DeGennaro, Stuart Malcolm, Lindsay Crompton, Krishna Vaddiparti, Lazarus K Mramba, Catherine Striley, Linda Cottler, Kellee Taylor, Robert Leverence
OBJECTIVE: To estimate the prevalence of hypertension, diabetes and chronic kidney disease and their risk factors in a rural and urban region of Haiti. SETTING AND PARTICIPANTS: Community health workers enumerated 2648 households (909 rural and 1739 urban) via a multistage cluster random sampling method from July 2015 to May 2016, completed 705 rural and 1419 urban assessments for adults aged 25-65 years. OUTCOME MEASURES: We performed a WHO STEPS based questionnaire, measured two blood pressure values, weight, height, abdominal circumference and point of care test finger stick blood sample for haemoglobin A1c, creatinine and cholesterol (total, high density lipoprotein (HDL) and triglycerides)...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678669/using-big-data-in-oncology-to-prospectively-impact-clinical-patient-care-a-proof-of-concept-study
#4
Vérène Dougoud-Chauvin, Jae Jin Lee, Edgardo Santos, Vonetta L Williams, Nicolò M L Battisti, Kavita Ghia, Marina Sehovic, Cortlin Croft, Jongphil Kim, Lodovico Balducci, Julie A Kish, Martine Extermann
OBJECTIVE: Big Data is widely seen as a major opportunity for progress in the practice of personalized medicine, attracting the attention from medical societies and presidential teams alike as it offers a unique opportunity to enlarge the base of evidence, especially for older patients underrepresented in clinical trials. This study prospectively assessed the real-time availability of clinical cases in the Health & Research Informatics Total Cancer Care™ (TCC) database matching community patients with cancer, and the impact of such a consultation on treatment...
April 17, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29678155/a-stepped-wedge-implementation-and-evaluation-of-the-healthy-active-peaceful-playgrounds-for-youth-happy-intervention
#5
Dean Dudley, Wayne Cotton, Louisa Peralta, Matthew Winslade
BACKGROUND: Increasing physical activity in children is a health priority. The Healthy Active Peaceful Playgrounds for Youth (HAPPY) study aimed to examine a multi-component playground intervention designed to increase the proportion of physical activity during recess and lunch of primary school students. METHODS: The 2016 Australian focused HAPPY Study was a 12-month, metropolitan primary school based intervention, which was evaluated using a stepped wedge design...
April 20, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29678090/a-system-for-supporting-development-and-update-of-the-international-classification-of-health-interventions-ichi
#6
Marc Donada, Vincenzo Della Mea, Megan Cumerlato, Nicole Rankin, Richard Madden
The International Classification of Health Interventions (ICHI) is a member of the WHO Family of International Classifications, being developed to provide a common tool for reporting and analysing health interventions for statistical purposes. A web-based platform for classification development and update has been specifically developed to support the initial development step and then, after final approval, the continuous revision and update of the classification. The platform provides features for classification editing, versioning, comment management and URI identifiers...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29676258/-multiple-uses-of-skeletal-anchorages-taking-advantage-of-mini-screws-to-improve-aesthetics-with-active-and-passive-appliances
#7
Stéphane Renger, Mélanie Gremeret, Sarah Gebeile-Chauty
INTRODUCTION: The main causes of failures in canine traction are anchorage defects, incorrect direction of force, uncontrolled forces. An adolescent female (10 years, 9 months) presents with two included canines on the maxillary arch, in a palatal position and her lateral incisors (12 and 22) are microdontic. Two mini-screws are inserted on the palate, in a mesial position to 16 and 26 to secure the traction of 13 and 23; in general, braces are bonded after this first step. After debonding, mini-screws remain to help stabilize the palatal plate during the retention period and to avoid unaesthetic metallic wires and hooks which sometimes cause occlusal interferences...
March 2018: L' Orthodontie Française
https://www.readbyqxmd.com/read/29676054/considering-the-interdependence-of-clinical-performance-implications-for-assessment-and-entrustment
#8
Stefanie S Sebok-Syer, Saad Chahine, Christopher J Watling, Mark Goldszmidt, Sayra Cristancho, Lorelei Lingard
INTRODUCTION: Our ability to assess independent trainee performance is a key element of competency-based medical education (CBME). In workplace-based clinical settings, however, the performance of a trainee can be deeply entangled with others on the team. This presents a fundamental challenge, given the need to assess and entrust trainees based on the evolution of their independent clinical performance. The purpose of this study, therefore, was to understand what faculty members and senior postgraduate trainees believe constitutes independent performance in a variety of clinical specialty contexts...
April 19, 2018: Medical Education
https://www.readbyqxmd.com/read/29675515/ceramic-surface-treatment-with-a-single-component-primer-resin-adhesion-to-glass-ceramics
#9
Mayara Prado, Catina Prochnow, Ana Maria Estivalete Marchionatti, Paolo Baldissara, Luiz Felipe Valandro, Vinicius Felipe Wandscher
PURPOSE: To evaluate the microshear bond strength (μSBS) of composite cement bonded to two machined glass ceramics and its durability, comparing conventional surface conditioning (hydrofluoric acid + silane) to a one-step primer (Monobond Etch & Prime). MATERIALS AND METHODS: Machined slices of lithium disilicate ceramic (LDC) (IPS e.max CAD) and feldspathic ceramic (FC) (VITA Mark II) glass ceramics were divided into two groups (n = 10) according to two factors: 1...
April 19, 2018: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/29674981/comparative-effect-of-collaborative-care-pain-medication-and-duloxetine-in-the-treatment-of-major-depressive-disorder-and-comorbid-sub-chronic-pain-results-of-an-exploratory-randomized-placebo-controlled-multicenter-trial-cc-paindip
#10
Eric W de Heer, Jack Dekker, Aartjan T F Beekman, Harm W J van Marwijk, Tjalling J Holwerda, Pierre M Bet, Joost Roth, Lotte Timmerman, Christina M van der Feltz-Cornelis
Objective: Evidence exists for the efficacy of collaborative care (CC) for major depressive disorder (MDD), for the efficacy of the consequent use of pain medication against pain, and for the efficacy of duloxetine against both MDD and neuropathic pain. Their relative effectiveness in comorbid MDD and pain has never been established so far. This study explores the effectiveness of CC with pain medication and duloxetine, and CC with pain medication and placebo, compared with duloxetine alone, on depressive and pain symptoms...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29674319/long-repeating-ttaggg-n-single-stranded-dna-self-condenses-into-compact-beaded-filaments-stabilized-by-g-quadruplex-formation
#11
Anirban Kar, Nathan Jones, N Özlem Arat, Richard Fishel, Jack Griffith
Conformations adopted by long stretches of single stranded DNA (ssDNA) are of central interest in understanding the architecture of replication forks, R loops, and other structures generated during DNA metabolism in vivo. This is particularly so if the ssDNA consists of short nucleotide repeats. Such studies have been hampered by the lack of defined substrates greater than ~150 nt, and the absence of high-resolution biophysical approaches. Here we describe the generation of very long ssDNA consisting of the mammalian telomeric repeat (5'-TTAGGG-3')n as well as the interrogation of its structure by electron microscopy (EM) and single molecule magnetic tweezers (smMT)...
April 19, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29674310/the-interactive-child-distress-screener-development-and-preliminary-feasibility-testing
#12
Sonja March, Jamin Day, Kirsty Zieschank, Michael Ireland
BACKGROUND: Early identification of child emotional and behavioral concerns is essential for the prevention of mental health problems; however, few suitable child-reported screening measures are available. Digital tools offer an exciting opportunity for obtaining clinical information from the child's perspective. OBJECTIVE: The aim of this study was to describe the initial development and pilot testing of the Interactive Child Distress Screener (ICDS). The ICDS is a Web-based screening instrument for the early identification of emotional and behavioral problems in children aged between 5 and 12 years...
April 19, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29674246/a-microrna-expression-signature-of-the-postprandial-state-in-response-to-a-high-saturated-fat-challenge
#13
Sergio Lopez, Beatriz Bermudez, Sergio Montserrat-de la Paz, Rocio Abia, Francisco J G Muriana
The postprandial hypertriglyceridemia is an important and largely silent disturbance involved in the genesis of numerous pathological conditions. Exaggerated and prolonged states of postprandial hypertriglyceridemia are frequently related to the ingestion of meals enriched in saturated fatty acids (SFAs). MicroRNAs are noncoding RNAs that function as gene regulators and play significant roles in both health and disease. However, differential miRNA expression between fasting and postprandial states has never been elucidated...
March 18, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29674010/one-step-intraoperative-radiotherapy-optimizes-conservative-treatment-of-breast-cancer-with-advantages-in-quality-of-life-and-work-resumption
#14
Luca Sorrentino, Susanna Fissi, Ilaria Meaglia, Daniela Bossi, Ottavia Caserini, Serena Mazzucchelli, Marta Truffi, Sara Albasini, Paola Tabarelli, Marco Liotta, Giovanni B Ivaldi, Fabio Corsi
BACKGROUND: Intraoperative radiotherapy (IORT) could be not-inferior to external beam radiotherapy (EBRT) in selected patients, but toxicities, self-perception of body image, quality of life, and resumption of work or daily activities have been poorly explored. The aim of the present study was to compare these outcomes between EBRT, IORT full-dose (IORT-f) and IORT boost (IORT-b). METHODS: 443 consecutive patients, candidates for breast-conserving surgery, were included: EBRT was performed in 220 patients (49...
April 16, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29673848/overcoming-missed-opportunities-in-diabetes-management-to-improve-outcomes-for-hospitalized-patients-with-diabetes
#15
Michael Oravec, James Salem, Jason Kunz, Michelle Cudnik, Lynn Clough, Robert Woods, Megan Elavsky
AIMS: The purpose of this study is to assess the impact of hospitalization on 6-12 month medication adjustment and glycemic control. METHODS: We conducted a retrospective cohort study of hospitalized and non-hospitalized patients with diabetes of an internal medicine residency continuity clinic. Patients had baseline and outcome HbA1c taken 6-12 months apart. Multivariate linear regression was used to model predictors of HbA1c change from baseline to outcome. Multivariate logistic regression was used to model predictors of medication adjustment between baseline and outcome clinic visits...
April 16, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29673337/communities-in-charge-of-alcohol-cica-a-protocol-for-a-stepped-wedge-randomised-control-trial-of-an-alcohol-health-champions-programme
#16
Penny A Cook, Suzy C Hargreaves, Elizabeth J Burns, Frank de Vocht, Steve Parrott, Margaret Coffey, Suzanne Audrey, Cathy Ure, Paul Duffy, David Ottiwell, Kiran Kenth, Susan Hare, Kate Ardern
BACKGROUND: Communities In Charge of Alcohol (CICA) takes an Asset Based Community Development (ABCD) approach to reducing alcohol harm. Through a cascade training model, supported by a designated local co-ordinator, local volunteers are trained to become accredited 'Alcohol Health Champions' to provide brief opportunistic advice at an individual level and mobilise action on alcohol availability at a community level. The CICA programme is the first time that a devolved UK region has attempted to coordinate an approach to building health champion capacity, presenting an opportunity to investigate its implementation and impact at scale...
April 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29673061/decellularization-and-characterization-of-a-whole-intervertebral-disc-xenograft-scaffold
#17
Austin Hensley, Jess Rames, Victor Casler, Christopher Rood, Joshua Walters, Christopher Fernandez, Sanjitpal Gill, Jeremy Mercuri
Intervertebral disc (IVD) degeneration is a multi-factor process that results in the physical destruction of the nucleus pulposus (NP) and annulus fibrosus (AF). This compromises IVD function and causes significant disability and economic burden. Strategies to replace the entire composite structure of the IVD are limited and most approaches do not recapitulate the heterogenous biochemical composition, micro-architecture or mechanical properties of the native tissue. Our central hypothesis was that donor IVDs which resemble the size and biochemistry of human lumbar IVDs could be successfully decellularized while retaining the tissue's structure and function with the long-term goal of creating a composite scaffold for tissue engineering the human IVD...
April 19, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29670857/radiomics-evaluation-of-histological-heterogeneity-using-multiscale-textures-derived-from-3d-wavelet-transformation-of-multispectral-images
#18
Ahmad Chaddad, Paul Daniel, Tamim Niazi
Purpose: Colorectal cancer (CRC) is markedly heterogeneous and develops progressively toward malignancy through several stages which include stroma (ST), benign hyperplasia (BH), intraepithelial neoplasia (IN) or precursor cancerous lesion, and carcinoma (CA). Identification of the malignancy stage of CRC pathology tissues (PT) allows the most appropriate therapeutic intervention. Methods: This study investigates multiscale texture features extracted from CRC pathology sections using 3D wavelet transform (3D-WT) filter...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29670495/impact-of-pilates-exercise-in-multiple-sclerosis-a-randomized-controlled-trial
#19
Whitney R D Duff, Justin W Andrushko, Doug W Renshaw, Philip D Chilibeck, Jonathan P Farthing, Jana Danielson, Charity D Evans
Background: Pilates is a series of exercises based on whole-body movement and may improve mobility in people with multiple sclerosis (MS). The purpose of this study was to determine the effect of Pilates on walking performance in people with MS. Methods: 30 individuals with MS who were not restricted to a wheelchair or scooter (Patient-Determined Disease Steps scale score <7) were randomized to receive Pilates (twice weekly) and massage therapy (once weekly) or once-weekly massage therapy only (control group)...
March 2018: International Journal of MS Care
https://www.readbyqxmd.com/read/29670055/a-new-vegetation-segmentation-approach-for-cropped-fields-based-on-threshold-detection-from-hue-histograms
#20
Mohamed Hassanein, Zahra Lari, Naser El-Sheimy
Over the last decade, the use of unmanned aerial vehicle (UAV) technology has evolved significantly in different applications as it provides a special platform capable of combining the benefits of terrestrial and aerial remote sensing. Therefore, such technology has been established as an important source of data collection for different precision agriculture (PA) applications such as crop health monitoring and weed management. Generally, these PA applications depend on performing a vegetation segmentation process as an initial step, which aims to detect the vegetation objects in collected agriculture fields&rsquo; images...
April 18, 2018: Sensors
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