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https://www.readbyqxmd.com/read/27921256/impact-of-bridging-income-generation-with-group-integrated-care-bigpic-on-hypertension-and-diabetes-in-rural-western-kenya
#1
Sonak D Pastakia, Simon M Manyara, Rajesh Vedanthan, Jemima H Kamano, Diana Menya, Benjamin Andama, Cleophas Chesoli, Jeremiah Laktabai
BACKGROUND: Rural settings in Sub-Saharan Africa (SSA) consistently report low participation in non-communicable disease (NCD) treatment programs and poor outcomes. OBJECTIVE: The objective of this study is to assess the impact of the implementation of a patient-centered rural NCD care delivery model called Bridging Income Generation through grouP Integrated Care (BIGPIC). DESIGN: The study prospectively tracked participation and health outcomes for participants in a screening event and compared linkage frequencies to a historical comparison group...
December 5, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27921071/validation-of-automatic-joint-space-width-measurements-in-hand-radiographs-in-rheumatoid-arthritis
#2
Olga Schenk, Yinghe Huo, Koen L Vincken, Mart A van de Laar, Ina H H Kuper, Kees C H Slump, Floris P J G Lafeber, Hein J Bernelot Moens
Computerized methods promise quick, objective, and sensitive tools to quantify progression of radiological damage in rheumatoid arthritis (RA). Measurement of joint space width (JSW) in finger and wrist joints with these systems performed comparable to the Sharp-van der Heijde score (SHS). A next step toward clinical use, validation of precision and accuracy in hand joints with minimal damage, is described with a close scrutiny of sources of error. A recently developed system to measure metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints was validated in consecutive hand images of RA patients...
October 2016: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27919387/impacts-of-structuring-the-electronic-health-record-results-of-a-systematic-literature-review-from-the-perspective-of-secondary-use-of-patient-data
#3
REVIEW
Riikka Vuokko, Päivi Mäkelä-Bengs, Hannele Hyppönen, Minna Lindqvist, Persephone Doupi
PURPOSE: To explore the impacts that structuring of electronic health records (EHRs) has had from the perspective of secondary use of patient data as reflected in currently published literature. This paper presents the results of a systematic literature review aimed at answering the following questions; (1) what are the common methods of structuring patient data to serve secondary use purposes; (2) what are the common methods of evaluating patient data structuring in the secondary use context, and (3) what impacts or outcomes of EHR structuring have been reported from the secondary use perspective...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27919242/reducing-child-abuse-amongst-adolescents-in-low-and-middle-income-countries-a-pre-post-trial-in-south-africa
#4
Lucie Cluver, Franziska Meinck, Alexa Yakubovich, Jenny Doubt, Alice Redfern, Catherine Ward, Nasteha Salah, Sachin De Stone, Tshiamo Petersen, Phelisa Mpimpilashe, Rocio Herrero Romero, Lulu Ncobo, Jamie Lachman, Sibongile Tsoanyane, Yulia Shenderovich, Heidi Loening, Jasmina Byrne, Lorraine Sherr, Lauren Kaplan, Frances Gardner
BACKGROUND: No known studies have tested the effectiveness of child abuse prevention programmes for adolescents in low- or middle-income countries. 'Parenting for Lifelong Health' ( http://tiny.cc/whoPLH ) is a collaborative project to develop and rigorously test abuse-prevention parenting programmes for free use in low-resource contexts. Research aims of this first pre-post trial in South Africa were: i) to identify indicative effects of the programme on child abuse and related outcomes; ii) to investigate programme safety for testing in a future randomised trial, and iii) to identify potential adaptations...
July 13, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27918993/tetrahydropyranodiquinolin-8-amines-as-new-non-hepatotoxic-antioxidant-and-acetylcholinesterase-inhibitors-for-alzheimer-s-disease-therapy
#5
Youssef Dgachi, Olga Sokolov, Vincent Luzet, Justyna Godyń, Dawid Panek, Alexandre Bonet, Hélène Martin, Isabel Iriepa, Ignacio Moraleda, Cristina García-Iriepa, Jana Janockova, Lysiane Richert, Ondrej Soukup, Barbara Malawska, Fakher Chabchoub, José Marco-Contelles, Lhassane Ismaili
Herein we report an efficient two step synthesis and biological assessment of 12 racemic tetrahydropyranodiquinolin-8-amines derivatives as antioxidant, cholinesterase inhibitors and non-hepatotoxic agents. Based on the results of the primary screening, we identified 7-(3-methoxyphenyl)-9,10,11,12-tetrahydro-7H-pyrano[2,3-b:5,6-h']diquinolin-8-amine (2h) as a particularly interesting non-hepatotoxic compound that shows moderate antioxidant activity (1.83 equiv Trolox in the ORAC assay), a non competitive inhibition of hAChE (IC50 = 0...
November 23, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27918931/effectiveness-of-an-educational-intervention-the-encourage-autonomous-self-enrichment-program-in-patients-with-chronic-kidney-disease-a-randomized-controlled-trial
#6
Hiroko Joboshi, Michiyo Oka
BACKGROUND: Self-management is an important step toward preventing and impeding the progression of chronic kidney disease. However, patients with chronic kidney disease may have few or no subjective symptoms and therefore might consider self-management to be unnecessary. Effective support and encouragement of self-management in patients with chronic kidney disease is therefore required. OBJECTIVES: This study tested the effectiveness of the Encourage Autonomous Self-Enrichment patient education program, which supports patient autonomy and intrinsic motivations with the aim of improving self-efficacy and sustaining self-management, on perceived self-efficacy, self-management behaviors, and physiological endpoints (blood pressure and renal function parameters) in patients with chronic kidney disease...
November 22, 2016: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/27918787/an-ovine-model-for-exclusive-endoscopic-ear-surgery
#7
Lukas Anschuetz, Marco Bonali, Michael Ghirelli, Francesco Mattioli, Domenico Villari, Marco Caversaccio, Livio Presutti
Importance: With the international spread of exclusive transcanal endoscopic ear surgery, the need for a suitable and affordable surgical training model has grown during the past years. Objective: To develop and validate an ex vivo animal model for exclusive endoscopic ear surgery. Design, Setting, and Animal Models: In an experimental study, we compared ovine and human middle ear anatomy in 4 specimens and assessed the lamb as a model for endoscopic ear surgery...
December 1, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27918712/cost-utility-of-stepped-care-targeting-psychological-distress-in-patients-with-head-and-neck-or-lung-cancer
#8
Femke Jansen, Anna M H Krebber, Veerle M H Coupé, Pim Cuijpers, Remco de Bree, Annemarie Becker-Commissaris, Egbert F Smit, Annemieke van Straten, Guus M Eeckhout, Aartjan T F Beekman, C René Leemans, Irma M Verdonck-de Leeuw
Purpose A stepped care (SC) program in which an effective yet least resource-intensive treatment is delivered to patients first and followed, when necessary, by more resource-intensive treatments was found to be effective in improving distress levels of patients with head and neck cancer or lung cancer. Information on the value of this program for its cost is now called for. Therefore, this study aimed to assess the cost-utility of the SC program compared with care-as-usual (CAU) in patients with head and neck cancer or lung cancer who have psychological distress...
December 5, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27918692/the-validity-and-reliability-of-an-iphone-app-for-measuring-running-mechanics
#9
Carlos Balsalobre-Fernández, Hovannes Agopyan, Jean-Benoit Morin
The purpose of this investigation was to analyze the validity of an iPhone application (Runmatic) for measuring running mechanics. To do this, 96 steps from 12 different runs at speeds ranging from 2.77-5.55 m·s-1 were recorded simultaneously with Runmatic as well as with an opto-electronic device installed on a motorized treadmill to measure the contact and aerial time of each step. Additionally, several running mechanics variables were calculated using the contact and aerial times measured and previously validated equations...
December 5, 2016: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/27918630/changes-in-gait-patterns-induced-by-rhythmic-auditory-stimulation-for-adolescents-with-acquired-brain-injury
#10
Soo Ji Kim, Yoon-Kyum Shin, Ga Eul Yoo, Hyun Ju Chong, Sung-Rae Cho
The effects of rhythmic auditory stimulation (RAS) on gait in adolescents with acquired brain injury (ABI) were investigated. A total of 14 adolescents with ABI were initially recruited, and 12 were included in the final analysis (n = 6 each). They were randomly assigned to the experimental (RAS) or the control (conventional gait training) groups. The experimental group received gait training with RAS three times a week for 4 weeks. For both groups, spatiotemporal parameters and kinematic data, such as dynamic motions of joints on three-dimensional planes during a gait cycle and the range of motion in each joint, were collected...
December 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27917741/the-behaviour-and-welfare-of-sows-and-piglets-in-farrowing-crates-or-lactation-pens
#11
C Singh, M Verdon, G M Cronin, P H Hemsworth
Temporary confinement during parturition and early postpartum may provide an intermediary step preceding loose housing that offers improvement in sow and piglet welfare. Three experiments were conducted to investigate the implications of replacing farrowing crates (FCs) with an alternative housing system from 3 days postpartum until weaning. In each experiment sows farrowed in FCs and were randomly allocated at day 3 of lactation to either a FC or a pen with increased floor space (lactation pen (LP)) until weaning...
December 5, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27917299/a-male-with-extreme-subcutaneous-insulin-resistance-a-case-report
#12
Zuhayer Ahmed, Indrajit Prasad, Hafizur Rahman, Jalil Ansari, Khaled Hassan
INTRODUCTION: Though insulin has no upper limit in dosage, we do not encounter very high dose requirements too often. The reported case is the first in Bangladesh to require more than 1000 international units (IU) of subcutaneous insulin per day. CASE PRESENTATION: A 44-year old male diabetic patient from Bangladesh presented with unusually uncontrolled diabetes mellitus due to extreme insulin resistance. Despite dramatic increase in insulin step by step up to 1110 IU of concomitant short and intermediate acting insulin per day by subcutaneous route, his blood glucose remained over 12 mmol/L persistently, in all the fasting, pre-prandial, postprandial and random samples...
June 2016: Rom J Diabetes Nutr Metab Dis
https://www.readbyqxmd.com/read/27916569/insight-into-the-biochemical-kinetic-and-spectroscopic-characterization-of-garlic-allium-sativum-phytocystatin-implication-for-cardiovascular-disease
#13
Mohd Faizan Siddiqui, Azaj Ahmed, Bilqees Bano
Phytocystatins are cysteine proteinase inhibitors present in plants. They play crucial role in maintaining protease-anti protease balance and are involved in various endogenous processes. Thus, they are suitable and convenient targets for genetic engineering which makes their isolation and characterisation from different sources the need of the hour. In the present study a phytocystatin has been isolated from garlic (Allium sativum) by a simple two-step process using ammonium sulphate fractionation and gel filtration chromatography on Sephacryl S-100HR with a fold purification of 152...
December 1, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27916356/analysis-of-model-development-strategies-predicting-ventral-hernia-recurrence
#14
Julie L Holihan, Linda T Li, Erik P Askenasy, Jacob A Greenberg, Jerrod N Keith, Robert G Martindale, J Scott Roth, Mike K Liang
BACKGROUND: There have been many attempts to identify variables associated with ventral hernia recurrence; however, it is unclear which statistical modeling approach results in models with greatest internal and external validity. We aim to assess the predictive accuracy of models developed using five common variable selection strategies to determine variables associated with hernia recurrence. METHODS: Two multicenter ventral hernia databases were used. Database 1 was randomly split into "development" and "internal validation" cohorts...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27915266/systematic-ajmaline-challenge-in-patients-with-long-qt-3-syndrome-caused-by-the-most-common-mutation-a-multicentre-study
#15
Stephan Hohmann, Boris Rudic, Torsten Konrad, David Duncker, Thorben König, Erol Tülümen, Thomas Rostock, Martin Borggrefe, Christian Veltmann
AIMS: Overlap syndromes of long QT 3 syndrome (LQT3) and the Brugada syndrome (BrS) have been reported. Identification of patients with an overlapping phenotype is crucial before initiation of Class I antiarrhythmic drugs for LQT3. Aim of the present study was to elucidate the yield of ajmaline challenge in unmasking the Brugada phenotype in patients with LQT3 caused by the most common mutation, SCN5A-E1784K. METHODS AND RESULTS: Consecutive families in tertiary referral centres diagnosed with LQT3 caused by SCN5A-E1784K were included in the study...
December 2, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27915183/search-for-new-potential-anticonvulsants-with-anxiolytic-and-antidepressant-properties-among-derivatives-of-4-4-diphenylpyrrolidin-2-one
#16
Katarzyna Malawska, Aleksandra Rak, Beata Gryzło, Kinga Sałat, Małgorzata Michałowska, Elżbieta Żmudzka, Krzysztof Lodarski, Barbara Malawska, Katarzyna Kulig
BACKGROUND: The aim of this study was to synthesize a series of new N-Mannich bases derived from 4,4-diphenylpyrrolidin-2-one having differently substituted 4-phenylpiperazines as potential anticonvulsant agents with additional (beneficial) pharmacological properties. METHODS: The target compounds 8-12 were prepared in one step from the 4-substituted phenylpiperazines, paraformaldehyde, and synthesized 4,4-diphenylpyrrolodin-2-one (7) by a Mannich-type reaction...
September 22, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27914817/what-really-happens-in-the-home-the-medication-environment-of-urban-minority-youth
#17
Andrea A Pappalardo, Kelly Karavolos, Molly A Martin
BACKGROUND: Asthma disproportionately affects minority youth. Understanding the home medication environment and its relation to medication adherence can shape interventions to improve health outcomes. OBJECTIVE: The objective of this study was to describe the asthma medication environment in the homes of urban minority youth and to determine predictors of medication use and technique in this population. METHODS: Baseline data from 2 cohorts of minority youth with asthma in Chicago were combined for cross-sectional analysis...
November 30, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27914333/nano-zinc-oxide-incorporated-graphene-oxide-nanocellulose-composite-for-the-adsorption-and-photo-catalytic-degradation-of-ciprofloxacin-hydrochloride-from-aqueous-solutions
#18
T S Anirudhan, J R Deepa
Purpose of this study is to report the synthetic procedure of a novel photo catalyst, nano zinc oxide incorporated graphene oxide/nanocellulose (ZnO-GO/NC) for the effective adsorption and subsequent photo degradation of ciprofloxacin (CF), an antibiotic widely used in the poultry. Self cleaning property in cellulose was achieved by introducing a nano zinc oxide incorporated graphene oxide into nanocellulose (NC) matrix. By incorporating nano zinc oxide (ZnO) in graphene oxide (GO), band gap could be tuned to 2...
November 17, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914260/the-extent-of-fermentative-transformation-of-phenolic-compounds-in-the-bioanode-controls-exoelectrogenic-activity-in-a-microbial-electrolysis-cell
#19
Xiaofei Zeng, Maya A Collins, Abhijeet P Borole, Spyros G Pavlostathis
Phenolic compounds in hydrolysate/pyrolysate and wastewater streams produced during the pretreatment of lignocellulosic biomass for biofuel production present a significant challenge in downstream processes. Bioelectrochemical systems are increasingly recognized as an alternative technology to handle biomass-derived streams and to promote water reuse in biofuel production. Thus, a thorough understanding of the fate of phenolic compounds in bioanodes is urgently needed. The present study investigated the biotransformation of three structurally similar phenolic compounds (syringic acid, SA; vanillic acid, VA; 4-hydroxybenzoic acid, HBA), and their individual contribution to exoelectrogenesis in a microbial electrolysis cell (MEC) bioanode...
November 27, 2016: Water Research
https://www.readbyqxmd.com/read/27914189/analysis-of-experiences-with-exclusive-breastfeeding-among-hiv-positive-mothers-in-lusaka-zambia
#20
Alice Ngoma-Hazemba, Busisiwe Purity Ncama
BACKGROUND: Exclusive breastfeeding in the first 6 months offers protection from postnatal HIV infection but remains low in resource-poor settings. Documentation of experiences with exclusive breastfeeding is needed to strengthen infant feeding counselling by health care workers. OBJECTIVE: To explore HIV-positive mothers' experiences with exclusive breastfeeding during the first 6 months of the infant's life. DESIGN: A health facility- and community-based exploratory qualitative study was conducted among 30 HIV-positive mothers practising exclusive breastfeeding and meeting the selection criteria...
2016: Global Health Action
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