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https://www.readbyqxmd.com/read/28821182/microsatellite-mutation-rate-in-atlantic-sturgeon-acipenser-oxyrinchus
#1
Hanna Panagiotopoulou, James D Austin, Katarzyna Zalewska, Magdalena Gonciarz, Kinga Czarnogórska, Jan Gawor, Piotr Weglenski, Danijela Popovic
Understanding mutation rates can greatly extend the utility of population and conservation genetic analyses. Herein, we present an estimate of genome-wide microsatellite mutation rate in Atlantic sturgeon (Acipenser oxyrinchus) based on parent-offspring transmission patterns. We screened 307 individuals for parentage and mutation-rate analysis applying 43 variable markers. Out of 13228 allele transfers, 11 mutations were detected, producing a mutation rate of 8.3 × 10-4 per locus per generation (95% confidence interval: 1...
September 1, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28820356/a-phantom-study-for-the-comparison-of-different-brands-of-computed-tomography-scanners-and-software-packages-for-endovascular-aneurysm-repair-sizing-and-planning
#2
Juliëtte F Velu, Erik Groot Jebbink, Jean-Paul Pm de Vries, Job Am van der Palen, Cornelis H Slump, Robert H Geelkerken
Objectives Correct sizing of endoprostheses used for the treatment of abdominal aortic aneurysms is important to prevent endoleaks and migration. Sizing requires several steps and each step introduces a possible sizing error. The goal of this study was to investigate the magnitude of these errors compared to the golden standard: a vessel phantom. This study focuses on the errors in sizing with three different brands of computed tomography angiography scanners in combination with three reconstruction software packages...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28820282/mir505-3p-regulates-axonal-development-via-inhibiting-the-autophagy-pathway-by-targeting-atg12
#3
Kan Yang, Bin Yu, Cheng Cheng, Tianlin Cheng, Bo Yuan, Kai Li, Junhua Xiao, Zilong Qiu, Yuxun Zhou
In addition to the canonical role in protein homeostasis, autophagy has recently been found to be involved in axonal dystrophy and neurodegeneration. Whether autophagy may also be involved in neural development remains largely unclear. Here we report that Mir505-3p is a crucial regulator for axonal elongation and branching in vitro and in vivo, through modulating autophagy in neurons. We identify that the key target gene of Mir505-3p in neurons is Atg12, encoding ATG12 (autophagy related 12) which is an essential component of the autophagy machinery during the initiation and expansion steps of autophagosome formation...
August 18, 2017: Autophagy
https://www.readbyqxmd.com/read/28819971/a-radical-based-synthesis-of-lingzhiol
#4
Lea-Marina Mehl, Martin E Maier
The polycyclic natural product lingzhiol [(±)-1] was synthesized from dimethoxytetralone 8 via cyclization of an intermediate benzylic radical, generated from spiroepoxide 14, onto an alkynyl substituent generating the tetracyclic compound 13 with an exocyclic double bond. After oxidative cleavage of the double bond of 13 and reduction of the keto function of 23, the correct diastereomer 12-syn was converted to lingzhiol (1) via known steps. In a similar manner, lingzhiol analog 39 was synthesized from 5-methoxy-tetralone (27)...
August 18, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28819868/one-level-step-section-histological-analysis-is-insufficient-to-confirm-complete-pathological-response-after-neoadjuvant-chemoradiation-for-rectal-cancer
#5
M A Pereira, A R Dias, S F Faraj, C S R Nahas, A R Imperiale, C F S Marques, G C Cotti, B C Camargo, S C Nahas, E S de Mello, U Ribeiro
BACKGROUND: Neoadjuvant chemoradiation therapy (nCRT) for rectal cancer may lead to cure. As we currently lack reliable methods to clinically confirm the absence of disease, some patients undergo radical resection and have pathological complete response (pCR) still undergo surgery. Furthermore, it is uncertain if conventional one-level histopathological analysis is accurate enough to determine complete response. Confirming pCR is essential to determine the prognosis and to consider the patient's inclusion in trials of adjuvant therapy...
August 17, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28819218/low-threshold-rhodamine-doped-whispering-gallery-mode-microlasers-fabricated-by-direct-laser-writing
#6
Nathália B Tomazio, Leonardo De Boni, Cleber R Mendonca
The combination of the outstanding properties of whispering gallery modes with both the flexibility and ease of processing of polymers is particularly attractive for photonics applications. However, the versatile fabrication of polymeric nano/microdevices with the desired photonic performance has proven challenging. Here, we report on lasing in Rhodamine B doped whispering gallery mode microcavities fabricated by direct laser writing via two-photon polymerization. Threshold pump energies as low as 12 nJ were achieved for free-space pulsed excitation at 532 nm...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819172/suppression-for-an-intermediate-phase-in-znsb-films-by-nio-doping
#7
Chao Li, Guoxiang Wang, Dongfeng Qi, Daotian Shi, Xianghua Zhang, Hui Wang
The structural evolution and phase-change kinetics of NiO-doped ZnSb films are investigated. NiO-doped ZnSb films exhibit a single-step crystallization process, which is different from that of undoped ZnSb. NiO-doped ZnSb can directly crystallize into a stable ZnSb phase at temperatures greater than 320 °C with suppression of a metastable ZnSb phase. These characteristics enlarge the amorphous/crystalline resistance ratio by approximately five orders of magnitude. Moreover, NiO doping of ZnSb films increases crystallization temperature from 260 to 275 °C, improves data retention temperature from 201...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818464/one-pot-synthesis-of-bioactive-cyclopentenones-from-%C3%AE-linolenic-acid-and-docosahexaenoic-acid
#8
Daniel Maynard, Sara Mareike Müller, Monika Hahmeier, Jana Löwe, Ivo Feussner, Harald Gröger, Andrea Viehhauser, Karl-Josef Dietz
Oxidation products of the poly-unsaturated fatty acids (PUFAs) arachidonic acid, α-linolenic acid and docosahexaenoic acid are bioactive in plants and animals as shown for the cyclopentenones prostaglandin 15d-PGJ2 and PGA2, cis-(+)-12-oxophytodienoic acid (12-OPDA), and 14-A-4 neuroprostane. In this study an inexpensive and simple enzymatic multi-step one-pot synthesis is presented for 12-OPDA, which is derived from α-linolenic acid, and the analogous docosahexaenoic acid (DHA)-derived cyclopentenone [(4Z,7Z,10Z)-12-[[-(1S,5S)-4-oxo-5-(2Z)-pent-2-en-1yl]-cyclopent-2-en-1yl] dodeca-4,7,10-trienoic acid, OCPD]...
August 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28818417/referral-for-expert-physical-activity-counseling-a-pragmatic-rct
#9
Erica L James, Ben D Ewald, Natalie A Johnson, Fiona G Stacey, Wendy J Brown, Elizabeth G Holliday, Mark Jones, Fan Yang, Charlotte Hespe, Ronald C Plotnikoff
INTRODUCTION: Primary care physicians are well placed to offer physical activity counseling, but insufficient time is a barrier. Referral to an exercise specialist is an alternative. In Australia, exercise specialists are publicly funded to provide face-to-face counseling to patients who have an existing chronic illness. This trial aimed to (1) determine the efficacy of primary care physicians' referral of insufficiently active patients for counseling to increase physical activity, compared with usual care, and (2) compare the efficacy of face-to-face counseling with counseling predominantly via telephone...
August 14, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28817611/the-directed-migration-of-gonadal-distal-tip-cells-in-caenorhabditis-elegans-requires-ngat-1-a-%C3%A3-1-4-n-acetylgalactosaminyltransferase-enzyme
#10
Joseph Veyhl, Robert J Dunn, Wendy L Johnston, Alexa Bennett, Lijia W Zhang, James W Dennis, Harry Schachter, Joseph G Culotti
Glycoproteins such as growth factor receptors and extracellular matrix have well-known functions in development and cancer progression, however, the glycans at sites of modification are often heterogeneous molecular populations which makes their functional characterization challenging. Here we provide evidence for a specific, discrete, well-defined glycan modification and regulation of a stage-specific cell migration in Caenorhabditis elegans. We show that a chain-terminating, putative null mutation in the gene encoding a predicted β1,4-N-acetylgalactosaminyltransferase, named ngat-1, causes a maternally rescued temperature sensitive (ts) defect in the second phase of the three phase migration pattern of the posterior, but not the anterior, hermaphrodite Distal Tip Cell (DTC)...
2017: PloS One
https://www.readbyqxmd.com/read/28816275/-clinical-application-of-retroperitoneal-laparoscopic-surgery-combined-with-mini-flank-incision-hybrid-surgery-for-partial-nephrectomy-of-complex-renal-tumors
#11
X J Ye, J Liu, A Ablimit, L L Xiong, S J Liu, T Xu, X B Huang
OBJECTIVE: To evaluate the clinical effect and safety of retroperitoneal laparoscopic surgery combined with mini-flank incision "hybrid surgery" for partial nephrectomy of complex renal tumors. METHODS: Between April 2015 and December 2016, the clinical data from 16 patients with complex renal tumors who underwent the "hybrid surgery", including 10 males and 6 females, were retrospectively reviewed. The average age was (50.2±10.7) years, 9 cases were located in the left side and 7 cases in the right side, the mean tumor size was (6...
August 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28815792/understanding-implications-of-consumer-behavior-for-wildlife-farming-and-sustainable-wildlife-trade
#12
A Nuno, J M Blumenthal, T J Austin, J Bothwell, G Ebanks-Petrie, B J Godley, A C Broderick
Unsustainable wildlife trade affects biodiversity and the livelihoods of communities dependent upon those resources. Wildlife farming has often been proposed to promote sustainable trade but characterizing markets and understanding consumer behaviour remain neglected, but essential, steps with important implications for its design and evaluation. We used sea turtle trade in the Cayman Islands as a case study - where turtle meat for consumption has been produced for almost 50 years, to explore consumer preferences towards wild-sourced (illegal) and farmed (legal) products and potential conservation implications...
August 16, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28815158/does-the-spine-surgeon-s-experience-affect-fracture-classification-assessment-of-stability-and-treatment-plan-in-thoracolumbar-injuries
#13
Shanmuganathan Rajasekaran, Rishi Mugesh Kanna, Gregory D Schroeder, Frank Cumhur Oner, Luiz Vialle, Jens Chapman, Marcel Dvorak, Michael Fehlings, Ajoy Prasad Shetty, Klaus Schnake, Frank Kandziora, Alexander R Vaccaro
STUDY DESIGN: Prospective survey-based study. OBJECTIVES: The AO Spine thoracolumbar injury classification has been shown to have good reproducibility among clinicians. However, the influence of spine surgeons' clinical experience on fracture classification, stability assessment, and decision on management based on this classification has not been studied. Furthermore, the usefulness of varying imaging modalities including radiographs, computed tomography (CT) and magnetic resonance imaging (MRI) in the decision process was also studied...
June 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28814255/current-evidence-on-the-evaluation-and-management-of-fever-without-a-source-in-infants-aged-0-90-days-a-review
#14
Joyee G Vachani, Kenya McNeal-Trice, Sowdhamini S Wallace
BACKGROUND: Despite development of risk stratification tools decades ago, the best strategy for evaluation and management of young infants with fever without a clear source remains uncertain. OBJECTIVE: To describe the variability in current practice and review recently published evidence in three key areas: inflammatory markers as a tool for risk stratification, impact of viral testing, and optimal observation time on antibiotics. METHODS: Articles were identified using PubMed, Scopus, and Cochrane databases and via experts...
August 16, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28813367/electron-transfer-processes-occurring-on-platinum-neural-stimulating-electrodes-pulsing-experiments-for-cathodic-first-charge-balanced-biphasic-pulses-for-0-566%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-k%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-2-3-in-rat-subcutaneous-tissues
#15
Doe W Kumsa, Narendra Bhadra, Eric M Hudak, J Thomas Mortimer
OBJECTIVE: Our mission is twofold: (1) find a way to safely inject more charge through platinum electrodes than the Shannon limit (k  =  1.75) permits and (2) nurture an interest in the neural stimulation community to understand the electron transfer process occurring on neural stimulating electrodes. APPROACH: We report here on measurements of the electrode potential, performed on platinum neural stimulating electrodes in the subcutaneous space of an anesthetized rat under neural stimulation conditions...
August 16, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28813187/twelve-steps-two-factors-coping-strategies-moderate-the-association-between-craving-and-daily-12-step-use-in-a-college-recovery-community
#16
Richard P Wiebe, Amanda M Griffin, Yao Zheng, Kitty S Harris, H Harrington Cleveland
BACKGROUND: Affiliating with 12-step groups appears to reduce relapse risk. By relying on between-person designs, extant research has been unable to examine daily mechanisms through which 12-step group affiliation contributes to recovery. OBJECTIVES: To examine the daily use and factor structure of the 12 steps and intrapersonal predictors and moderators of 12-step use. To determine whether the 12 steps were used in response to daily craving and, if so, which steps and in what contexts...
August 16, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28813087/validation-of-the-expression-and-emotion-scale-for-children-with-attention-deficit-hyperactivity-disorder-into-brazilian-portuguese
#17
Margarete Andreozzi Vaz Pereira Simon, Umbertina Conti Reed, Brigette Vaughan, Valdecir Antonio Simon, Erasmo Barbante Casella
Objective: To validate the parent-rated Expression and Emotion Scale for Children (EESC) for patients with attention-deficit/hyperactivity disorder (ADHD). Methods: The EESC was applied to parents of children with and without ADHD. The children were divided into age groups: Group A, between six and eight years old; Group B, between nine and 11 years old; and Group C, between 12 and 15 years old. The validation was carried out according to the steps proposed by Guillemin et al...
August 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28812160/robotic-versus-open-pancreatoduodenectomy-a-propensity-score-matched-analysis-based-on-factors-predictive-of-postoperative-pancreatic-fistula
#18
Niccolò Napoli, Emanuele F Kauffmann, Francesca Menonna, Francesca Costa, Sara Iacopi, Gabriella Amorese, Serena Giorgi, Angelo Baggiani, Ugo Boggi
BACKGROUND: Improvement in morbidity of pancreatoduodenectomy (PD) largely depends on the reduction in the incidence of clinically relevant (CR) postoperative pancreatic fistula (POPF). METHODS: After internal validation of the clinical risk score (CRS) of POPF, and identification of other predictive factors for POPF, robotic (RPD), and open (OPD) PDs were stratified into risk categories and matched by propensity scores. The primary endpoint of this study was incidence of CR-POPF...
August 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28811737/learning-and-developing-individual-exercise-skills-l-a-d-i-e-s-for-a-better-life-a-church-based-physical-activity-intervention-baseline-participant-characteristics
#19
Melicia C Whitt-Glover, Moses V Goldmon, Ziya Gizlice, Daniel P Heil, Njeri Karanja
OBJECTIVE: Physical activity (PA) is beneficial for health, yet most African American women do not achieve recommended levels. Successful, sustainable strategies could help to address disparities in health outcomes associated with low levels of PA. The Learning and Developing Individual Exercise Skills (L.A.D.I.E.S.) for a Better Life study compared a faith-based and a secular intervention for increasing PA with a self-guided control group. DESIGN SETTING AND PARTICIPANTS: This cluster randomized, controlled trial was conducted from 2010 - 2011 in African American churches (n=31) in suburban North Carolina...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/28811186/identification-and-characterization-of-small-molecule-inhibitors-of-porcine-reproductive-and-respiratory-syndrome-virus
#20
Alyssa B Evans, Pengfei Dong, Hyelee Loyd, Jianqiang Zhang, George A Kraus, Susan Carpenter
Porcine reproductive and respiratory syndrome virus (PRRSV) is the etiological agent of PRRS, an economically significant disease of swine worldwide. PRRSV is poorly controlled by the currently available vaccines, and alternative control strategies are needed to help prevent the continual circulation of the virus. Previously, we developed a synthetic route for the natural compound atractylodinol and demonstrated anti-PRRSV activity in vitro. However, the synthetic route was inefficient and the yield was poor...
August 12, 2017: Antiviral Research
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