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JOURNAL ARTICLE
Gianfranco Lauletta, Sebastiano Cicco, Franco Dammacco
BACKGROUND: Hepatitis C virus (HCV) chronic infection is frequently associated to autoimmune manifestations. The aim of this study was to prospectively evaluate the occurrence of clinical and/or laboratory features of autoimmunity in a cohort of 140 consecutive HCV chronically infected patients treated with direct-acting antiviral agents (DAAs) and followed-up for 96 weeks. METHODS: All patients were screened for cryoglobulins, rheumatoid factor (RF), C3, C4, antinuclear antibody (ANA), anti-smooth muscle (ASMA), anti-liver kidney microsome type 1 (anti-LKM1), anti-mitochondrial antibodies (AMA), anti-neutrophil cytoplasmic antibodies (ANCA), and anti-liver cytosol type 1/soluble liver antigen (anti-LC1/SLA) autoantibodies before therapy and 12, 48 and 96 weeks after treatment...
April 24, 2024: Minerva Medica
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JOURNAL ARTICLE
Samira Merali, David H Salinger, Maria Palmisano, Amy J Sehnert, Neelima Thanneer, Hyunmoon Back, Julie D Seroogy, Daniel D Gretler, Amit Roy, Vidya Perera
Mavacamten is the first cardiac myosin inhibitor approved by the US Food and Drug Administration for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (HCM). The phase III EXPLORER-HCM (NCT03470545) study used a dose-titration scheme based on mavacamten exposure and echocardiographic assessment of Valsalva left ventricular outflow tract gradient (VLVOTg) and left ventricular ejection fraction (LVEF). Using population pharmacokinetic/exposure-response modeling and simulations of virtual patients, this in silico study evaluated alternative dose-titration regimens for mavacamten, including regimens that were guided by echocardiographic measures only...
May 2, 2024: CPT: Pharmacometrics & Systems Pharmacology
#3
REVIEW
Amalie Oxholm Kusier, Thilde Risager Ubbesen, Anna Paldam Folker
INTRODUCTION: A large proportion of young people reports poor mental health, which is a major public health concern. Positive mental health is important for young people's development, quality of life, functioning in everyday life, and long-term possibilities. Thus, there is a great need to develop and implement mental health-promoting initiatives and activities in young people's lives. Participating in organized leisure communities has a positive impact on mental health and wellbeing...
2024: Frontiers in Public Health
#4
JOURNAL ARTICLE
Christiane Loerch, Leon-Phillip Szepanowski, Julian Reiss, James Adjaye, Nina Graffmann
The generation of iPSC-derived hepatocyte-like cells (HLCs) is a powerful tool for studying liver diseases, their therapy as well as drug development. iPSC-derived disease models benefit from their diverse origin of patients, enabling the study of disease-associated mutations and, when considering more than one iPSC line to reflect a more diverse genetic background compared to immortalized cell lines. Unfortunately, the use of iPSC-derived HLCs is limited due to their lack of maturity and a rather fetal phenotype...
2024: Frontiers in Cell and Developmental Biology
#5
REVIEW
Jeffery D St Jeor, Thomas W Mason, Mark A Glover, Nicholas A Trasolini, Brian R Waterman
BACKGROUND AND OBJECTIVE: Anterior shoulder dislocations can result in acute glenoid rim fractures that compromise the bony stability of the glenohumeral joint. Adequate fixation of these fractures is required to restore stability, decrease shoulder pain, and facilitate return to activity. The double-row suture bridge is a relatively novel fixation technique, first described in 2009, that accomplishes internal fixation with sufficient stability using an all-arthroscopic technique to restore the glenoid footprint...
2024: Annals of joint
#6
JOURNAL ARTICLE
Siddharth A, Raymond Haward, Ananya Chakraborty
Objective The objective of this study was to evaluate errors in the use of metered-dose inhalers (MDIs) among patients diagnosed with asthma or chronic obstructive pulmonary disease (COPD). Additionally, we aimed to assess improvements following corrective interventions. Settings and design This cross-sectional study was done by simple random sampling. Methods and materials This study was done at a tertiary care center in South India in an outpatient department and ward for tuberculosis and chest disease to find out the right way to use an MDI and investigate the reasons why people with asthma and COPD don't use it correctly...
April 2024: Curēus
#7
JOURNAL ARTICLE
Yan Chen, Jixin Lin, Ming Tao
BACKGROUND: The consumption of cheese and fish has been linked to the onset of depression. However, the connection between consuming cheese, consuming fish, experiencing depression, and the pathways that mediate this relationship remains unclear. The purpose of this research was to investigate the potential association between the consumption of cheese and fish and the occurrence of depression. Moreover, it is important to identify any metabolites that might be involved and understand their respective roles and functions...
2024: Frontiers in Nutrition
#8
JOURNAL ARTICLE
Mohammad Moatz Shollar, Joumaa Merza, Maher Darwish, Mohammad Keshe
In this study, two derivatives, namely the ester derivative cinnamoyl metronidazole and the amide derivative cinnamoyl memantine, were synthesized from cinnamic acid and respective drugs for the purpose of exploring their potential as novel and efficient antimicrobial agents in the quest of prevailing the global antimicrobial resistance challenge. The synthesis process involved two steps: first, the chlorination of cinnamic acid using thionyl chloride, and second, the esterification of metronidazole or the amidation of memantine...
May 15, 2024: Heliyon
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RANDOMIZED CONTROLLED TRIAL
Gyuri Kim, Seohyun Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
BACKGROUND: We investigated the effects of a physical activity encouragement intervention based on a smartphone personal health record (PHR) application (app) on step count increases, glycemic control, and body weight in patients with type 2 diabetes (T2D). METHODS: In this 12-week, single-center, randomized controlled, 12-week extension study, patients with T2D who were overweight or obese were randomized using ratio 1:2 to a group using a smartphone PHR app (control group) or group using the app and received individualized motivational text messages (intervention group) for 12 weeks...
May 1, 2024: BMC Medicine
#10
JOURNAL ARTICLE
Emily J Vogel, Milagros Neyra, David A Larsen, Teng Zeng
Wastewater-based epidemiology (WBE) has been widely implemented around the world as a complementary tool to conventional surveillance techniques to inform and improve public health responses. Currently, wastewater surveillance programs in the U.S. are evaluating integrated approaches to address public health challenges across multiple domains, including substance abuse. In this work, we demonstrated the potential of online solid-phase extraction coupled with liquid chromatography-high-resolution mass spectrometry to support targeted quantification and nontargeted analysis of psychoactive and lifestyle substances as a step toward understanding the operational feasibility of a statewide wastewater surveillance program for substance use assessment in New York...
May 1, 2024: Environmental Science & Technology
#11
JOURNAL ARTICLE
Alyssa O Vanderlinden, Masood Nevisipour, Thomas Sugar, Hyunglae Lee
Older adults have a decreased trunk movement control which is linked to their higher fall risk. While motor/cognitive dual-tasking deteriorates balance and walking in older adults, there is limited understanding on how trunk kinematics and kinetics are affected by dual-tasking in scenarios where falls can occur. Therefore, the purpose of the study was to determine the impacts of a challenging motor dual-task, specifically obstacle avoidance during walking, on trunk and lower-body kinematics and kinetics of older adults compared to young adults...
April 30, 2024: Human Movement Science
#12
JOURNAL ARTICLE
Piotr H Skarzynski, Natalia Czajka, Rita Zdanowicz, Aleksandra Kolodziejak, Ewelina Bukato, Małgorzata Talarek, Zuzanna Pankowska, Henryk Skarzynski
INTRODUCTION: Central auditory processing disorders (CAPD) can significantly affect the daily functioning of a child, and the first step in determining whether rehabilitation procedures are required is a proper diagnosis. Different guidelines for making diagnoses have been published in the literature, and in various centers normative values for psychoacoustic tests of CAPD have been used internally. The material presented in this paper is based on more than 1000 children and is the largest collection so far published...
April 12, 2024: Journal of Communication Disorders
#13
JOURNAL ARTICLE
Felix Kluge, Yonatan E Brand, M Encarna Micó-Amigo, Stefano Bertuletti, Ilaria D'Ascanio, Eran Gazit, Tecla Bonci, Cameron Kirk, Arne Küderle, Luca Palmerini, Anisoara Paraschiv-Ionescu, Francesca Salis, Abolfazl Soltani, Martin Ullrich, Lisa Alcock, Kamiar Aminian, Clemens Becker, Philip Brown, Joren Buekers, Anne-Elie Carsin, Marco Caruso, Brian Caulfield, Andrea Cereatti, Lorenzo Chiari, Carlos Echevarria, Bjoern Eskofier, Jordi Evers, Judith Garcia-Aymerich, Tilo Hache, Clint Hansen, Jeffrey M Hausdorff, Hugo Hiden, Emily Hume, Alison Keogh, Sarah Koch, Walter Maetzler, Dimitrios Megaritis, Martijn Niessen, Or Perlman, Lars Schwickert, Kirsty Scott, Basil Sharrack, David Singleton, Beatrix Vereijken, Ioannis Vogiatzis, Alison Yarnall, Lynn Rochester, Claudia Mazzà, Silvia Del Din, Arne Mueller
BACKGROUND: Wrist-worn inertial sensors are used in digital health for evaluating mobility in real-world environments. Preceding the estimation of spatiotemporal gait parameters within long-term recordings, gait detection is an important step to identify regions of interest where gait occurs, which requires robust algorithms due to the complexity of arm movements. While algorithms exist for other sensor positions, a comparative validation of algorithms applied to the wrist position on real-world data sets across different disease populations is missing...
May 1, 2024: JMIR Formative Research
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JOURNAL ARTICLE
Arkasha Sadhewa, Lydia V Panggalo, Illene Nanine, Ric N Price, Kamala Thriemer, Ari W Satyagraha, Benedikt Ley
BACKGROUND: The WHO recommends routine testing of G6PD activity to guide radical cure in patients with Plasmodium vivax malaria. Females may have intermediate G6PD enzyme activity and to date, only complex diagnostics are able to reliably identify them. The semi-quantitative G6PD diagnostic "One Step G6PD Test" (Humasis, RoK; "RDT") is a lateral flow assay that can distinguish deficient, intermediate, and normal G6PD status and offers a simpler diagnostic alternative. METHODS: G6PD status of participants enrolled in Malinau and Nunukan Regencies and the capital Jakarta was assessed with the RDT, and G6PD activity was measured in duplicate by reference spectrophotometry...
2024: PloS One
#15
JOURNAL ARTICLE
Franziska Fink, Ivonne Kalter, Jenny-Victoria Steindorff, Hans Konrad Helmbold, Denny Paulicke, Patrick Jahn
BACKGROUND: The use of drones in the health care sector is increasingly being discussed against the background of the aging population and the growing shortage of skilled workers. In particular, the use of drones to provide medication in rural areas could bring advantages for the care of people with and without a need for care. However, there are hardly any data available that focus on the interaction between humans and drones. OBJECTIVE: This study aims to disclose and analyze factors associated with user acceptance of drone-based medication delivery to derive practice-relevant guidance points for participatory technology development (for apps and drones)...
April 30, 2024: JMIR Human Factors
#16
JOURNAL ARTICLE
Jéssica Alves Ribeiro, Felipe Barreto Schuch, Laís Tonello, Kleber F Meneghel Vargas, Silvio A Oliveira-Junior, Paulo T Müller, Daniel Boullosa
BACKGROUND: High-intensity intermittent training has emerged as an option for treating major depressive disorder (MDD). However, short sprint training (sSIT), an efficient HIIT modality, has not been tested yet for this purpose. The sSIT has been proven to induce the same metabolic adaptations, with the advantage of promoting lower muscle fatigue than other HIIT protocols. METHODS: Seventeen adult women diagnosed with moderate/severe MDD were randomly allocated into a sSIT group (n=9) or a control condition (n=8)...
2024: Frontiers in Psychiatry
#17
JOURNAL ARTICLE
Insights into designing educational materials for persons living with dementia: a focus group study.
Charity M Hoffman, Sarah E Vordenberg, Amanda N Leggett, Esther Akinyemi, Molly Turnwald, Donovan T Maust
BACKGROUND: Persons living with dementia (PLWD) may experience communication difficulties that impact their ability to process written and pictorial information. Patient-facing education may help promote discontinuation of potentially inappropriate medications for older adults without dementia, but it is unclear how to adapt this approach for PLWD. Our objective was to solicit feedback from PLWD and their care partners to gain insights into the design of PLWD-facing deprescribing intervention materials and PLWD-facing education material more broadly...
April 29, 2024: BMC Geriatrics
#18
JOURNAL ARTICLE
Chao Li, Fu-Chun Li
The aim of this study was to improve the process of microincision and endoscopic surgery for the treatment of Achilles tendon (AT) rupture using the modified minimally invasive Bunnell suture (MIBS) technique.From December 2019 to December 2021, 20 patients with AT rupture who visited the First Affiliated Hospital of Harbin Medical University (Harbin, China) underwent MIBS surgery.A total of 20 patients were included, of whom 18 (90.0%) were male and 2 (10.0%) were female. The mean age of the patients was 37...
April 29, 2024: Zeitschrift Für Orthopädie und Unfallchirurgie
#19
REVIEW
Kathryn Abell, Dorothy K Sit, Katherine L Wisner
BACKGROUND: Major depressive disorder is highly prevalent among persons with epilepsy (PWEs). Between 30% and 50% of PWEs suffer from depression. Many factors contribute to this prevalence, including the psychosocial impact of the diagnosis, restrictions on driving and certain types of work, and adverse effects associated with antiseizure medications. Without proper treatment, depressed PWEs have increased risks for suicide, strained relationships, lowered seizure control, and impairment in functioning...
May 2024: Journal of Clinical Psychopharmacology
#20
JOURNAL ARTICLE
Zerin Jannat, Hemel Das, Md Wazed Ali, Tasnuva Wahed, Md Nurul Alam, Md Jasim Uddin
BACKGROUND: Vaccination has been an indispensable step in controlling the coronavirus disease pandemic. In early 2021, Bangladesh launched a mass vaccination campaign to boost the COVID-19 vaccination rate when doses were available and immunized millions in the country. Although deemed a success, disparities became conspicuous in vaccination coverage across population of different socioeconomic background. METHODS: The purpose of this cross-sectional study was to assess the vaccination coverage for three doses and detect disparities in uptake of the COVID-19 vaccine among rural population of hard-to-reach areas and urban individuals belonging to the high-risk group -defined in our study as individuals from elusive population such as floating population/street dwellers, transgender, addicts and disabled population...
2024: PloS One
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