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https://www.readbyqxmd.com/read/28213547/laboratory-selection-and-characterization-of-resistance-to-the-bacillus-thuringiensis-vip3aa-toxin-in-heliothis-virescens-lepidoptera-noctuidae
#1
Brian R Pickett, Asim Gulzar, Juan Ferré, Denis J Wright
Laboratory selection with Vip3Aa of a field-derived population of Heliothis virescens produced >2040-fold resistance in 12 generations of selection. The Vip-Sel resistant population showed little cross-resistance to Cry1Ab and no cross-resistance to Cry1Ac. Resistance was unstable after 15 generations without exposure to the toxin. F1 reciprocal crosses between Vip-Unsel and Vip-Sel indicated a strong paternal influence on the inheritance of resistance. Resistance ranged from almost completely recessive (mean h = 0...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28213342/virtual-visits-for-acute-nonurgent-care-a-claims-analysis-of-episode-level-utilization
#2
Aliza S Gordon, Wallace C Adamson, Andrea R DeVries
BACKGROUND: Expansion of virtual health care-real-time video consultation with a physician via the Internet-will continue as use of mobile devices and patient demand for immediate, convenient access to care grow. OBJECTIVE: The objective of the study is to analyze the care provided and the cost of virtual visits over a 3-week episode compared with in-person visits to retail health clinics (RHC), urgent care centers (UCC), emergency departments (ED), or primary care physicians (PCP) for acute, nonurgent conditions...
February 17, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28213243/multi-residue-analysis-of-36-priority-and-emerging-pollutants-in-marine-echinoderms-holothuria-tubulosa-and-marine-sediments-by-solid-liquid-extraction-followed-by-dispersive-solid-phase-extraction-and-liquid-chromatography-tandem-mass-spectrometry-analysis
#3
J Martín, A Zafra-Gómez, F Hidalgo, A J Ibáñez-Yuste, E Alonso, J L Vilchez
Marine echinoderms are filter-feeding invertebrates widely distributed along the coasts, and which are therefore extensively exposed to anthropogenic xenobiotics. They can serve as good sentinels for monitoring a large variety of contaminants in marine ecosystems. In this context, a multi-residue analytical method has been validated and applied to Holothuria tubulosa specimens and marine sediments for the determination of 36 organic compounds, which belong to some of the most problematic groups of emerging and priority pollutants (perfluoroalkyl compounds, estrogens, parabens, benzophenones, plasticizers, surfactants, brominated flame retardants and alkylphenols)...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28212138/deep-learning-in-mammography-diagnostic-accuracy-of-a-multipurpose-image-analysis-software-in-the-detection-of-breast-cancer
#4
Anton S Becker, Magda Marcon, Soleen Ghafoor, Moritz C Wurnig, Thomas Frauenfelder, Andreas Boss
OBJECTIVES: The aim of this study was to evaluate the diagnostic accuracy of a multipurpose image analysis software based on deep learning with artificial neural networks for the detection of breast cancer in an independent, dual-center mammography data set. MATERIALS AND METHODS: In this retrospective, Health Insurance Portability and Accountability Act-compliant study, all patients undergoing mammography in 2012 at our institution were reviewed (n = 3228). All of their prior and follow-up mammographies from a time span of 7 years (2008-2015) were considered as a reference for clinical diagnosis...
February 16, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28209507/ultrasound-guided-pulsed-radiofrequency-stimulation-of-posterior-tibial-nerve-a-potential-novel-intervention-for-recalcitrant-plantar-fasciitis
#5
Yung-Tsan Wu, Chih-Ya Chang, Yu-Ching Chou, Chun-Chang Yeh, Tsung-Ying Li, Heng-Yi Chu, Liang-Cheng Chen
OBJECTIVE: To evaluate the therapeutic benefit of ultrasound-guided pulsed radiofrequency (PRF) stimulation at the posterior tibial nerve (PTN) in patients with recalcitrant plantar fasciitis (PF). DESIGN: A prospective, randomized, double-blinded, placebo-controlled trial (12-week follow-up). SETTING: Outpatient of local medical center settings. PARTICIPANTS: Thirty-six patients with recalcitrant PF were randomized and 36 participants were included in the final data analysis...
February 13, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28209271/a-simple-method-of-extracting-cap-antigen-of-pcv2b-from-emulsified-vaccines-for-testing-its-stability-and-antigenicity
#6
Cheng Yu, Xin Li, Wenzhen Diao, Jiwei Liu, Yunpeng Yao, Li Hua, Yaqin Yu, Yongli Yu, Liying Wang
Oil-based emulsions are commonly used adjuvants for veterinary vaccines. After formulation, it is required to extract protein antigens from emulsified vaccines for testing their stability and antigenicity. To establish a simple method to extract the protein antigens, two emulsified vaccines, designated as Cap-206 and Cap-35, were prepared by formulating a 28-kDa capsid protein (Cap) of PCV2b with ISA 206, a water-in-oil-in-water emulsion, or ISA 35, an oil-in-water emulsion. We found that the freeze-thaw-centrifugation method with steps of freezing at -20 °C for 12 h, thawing at room temperature and centrifuging at 9000×g for 10 min could separate the aqueous phase from Cap-206, and a centrifugation method by centrifuging at 9000×g for 10 min could isolate the aqueous portion from Cap-35...
February 10, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28208707/gaitkeeper-a-system-for-measuring-canine-gait
#7
Cassim Ladha, Jack O'Sullivan, Zoe Belshaw, Lucy Asher
It is understood gait has the potential to be used as a window into neurodegenerative disorders, identify markers of subclinical pathology, inform diagnostic algorithms of disease progression and measure the efficacy of interventions. Dogs' gaits are frequently assessed in a veterinary setting to detect signs of lameness. Despite this, a reliable, affordable and objective method to assess lameness in dogs is lacking. Most described canine lameness assessments are subjective, unvalidated and at high risk of bias...
February 8, 2017: Sensors
https://www.readbyqxmd.com/read/28202942/duration-of-shiv-production-by-infected-cells-is-not-exponentially-distributed-implications-for-estimates-of-infection-parameters-and-antiviral-efficacy
#8
Catherine A A Beauchemin, Tomoyuki Miura, Shingo Iwami
The duration of the eclipse phase, from cell infection to the production and release of the first virion progeny, immediately followed by the virus-production phase, from the first to the last virion progeny, are important steps in a viral infection, by setting the pace of infection progression and modulating the response to antiviral therapy. Using a mathematical model (MM) and data for the infection of HSC-F cells with SHIV in vitro, we reconfirm our earlier finding that the eclipse phase duration follows a fat-tailed distribution, lasting 19 h (18-20 h)...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28202929/prohibition-of-e-cigarettes-in-the-us-are-prohibitions-where-alcohol-is-consumed-related-to-lower-alcohol-consumption
#9
Alexandra R Hershberger, Kenny A Karyadi, Melissa A Cyders
Recently, research has suggested negative consequences related to electronic cigarette (e-cig) use, including the increased risk for alcohol use and abuse. Previous work found that cigarette smoking ban legislation lowered overall smoking and alcohol use rates; however, researchers have not yet examined the potential effects of prohibiting e-cig use. The present study surveyed 617 individuals from a community-based online sample in the US (mean age = 33.33, SD = 10.50, 54.7 per cent female) who reported their smoking/e-cig use status, alcohol consumption, and the presence of e-cig prohibitions where they consume alcohol...
December 2016: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28202383/a-randomized-controlled-trial-of-screening-risk-modification-and-physical-therapy-to-prevent-falls-among-the-elderly-recently-discharged-from-the-emergency-department-to-the-community-the-steps-to-avoid-falls-in-the-elderly-study
#10
David B Matchar, Pamela W Duncan, Christopher T C Lien, Marcus Eng Hock Ong, Mina Lee, Fei Gao, Rita Sim, Kirsten Eom
OBJECTIVE: To evaluate the effectiveness of a multifactorial, tailored program of physical therapy to reduce the occurrence of falls among a heterogeneous group of high-risk elderly Singaporeans recently discharged from the Emergency Department (ED). DESIGN: Randomized controlled trial. SETTING: Communities in Central and East regions in Singapore. PARTICIPANTS: 354 adults aged at least 65 years who were seen at ED for a fall or fall-related injuries and discharged home...
February 12, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28199375/has-universal-screening-with-xpert%C3%A2-mtb-rif-increased-the-proportion-of-multidrug-resistant-tuberculosis-cases-diagnosed-in-a-routine-operational-setting
#11
Pren Naidoo, Rory Dunbar, Judy Caldwell, Carl Lombard, Nulda Beyers
SETTING: Primary health services in Cape Town, South Africa where the introduction of Xpert® MTB/RIF (Xpert) enabled simultaneous screening for tuberculosis (TB) and drug susceptibility in all presumptive cases. STUDY AIM: To compare the proportion of TB cases with drug susceptibility tests undertaken and multidrug-resistant tuberculosis (MDR-TB) diagnosed pre-treatment and during the course of 1st line treatment in the previous smear/culture and the newly introduced Xpert-based algorithms...
2017: PloS One
https://www.readbyqxmd.com/read/28199148/presence-and-antimicrobial-resistance-of-escherichia-coli-in-ready-to-eat-foods-in-shaanxi-china
#12
Allah Bux Baloch, Hua Yang, Yuqing Feng, Meili Xi, Qian Wu, Qinhao Yang, Jingsi Tang, Xiangxiang He, Yingping Xiao, Xiaodong Xia
The aim of this study was to determine the presence and characteristics of Escherichia coli in ready-to-eat (RTE) foods. A total of 300 RTE foods samples were collected in Shaanxi Province, People's Republic of China: 50 samples of cooked meat, 165 samples of vegetable salad, 50 samples of cold noodles, and 35 samples of salted boiled peanuts. All samples were collected during summer (in July to October) 2011 and 2012 and surveyed for the presence of E. coli . E. coli isolates recovered were classified by phylogenetic typing using a PCR assay...
February 15, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28198972/postoperative-pain-intensity-after-using-different-instrumentation-techniques-a-randomized-clinical-study
#13
Ersan Çiçek, Mustafa Murat Koçak, Sibel Koçak, Baran Can Sağlam, Sevinç Aktemur Türker
Objectives: The aim of this clinical study was to evaluate the influence of the instrumentation techniques on the incidence and intensity of postoperative pain in single-visit root canal treatment. Material and Methods: Ninety patients with single root/canal and non-vital pulps were included. The patients were assigned into 3 groups according to root canal instrumentation technique used; modified step-back, reciprocal, and rotational techniques. Root canal treatment was carried out in a single visit and the severity of postoperative pain was assessed via 4-point pain intensity scale...
January 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28198724/engaging-learners-to-advance-medical-education
#14
Jesse Burk-Rafel, R Logan Jones, Janice L Farlow
Learners are a pillar of academic medicine, yet their voice is seldom heard in national and international scholarly conversations on medical education. However, learners are eager to contribute: in response to a recent open call from Academic Medicine, medical students and residents representing 98 institutions across 11 countries submitted 224 Letters to the Editor on wide-ranging topics. In this Invited Commentary, the authors-three medical students serving in national leadership roles-contextualize several themes discussed in these learner-authored letters...
February 14, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28198114/immunoaffinity-knockout-of-saponin-glycosides-from-asparagus-racemosus-to-assess-anti-lipid-peroxidation
#15
Churanya Onlom, Watoo Phrompittayarat, Waraporn Putalun, Neti Waranuch, Kornkanok Ingkaninan
INTRODUCTION: Asparagus racemosus Willd (Asparagaceae family), known as Shatavari, is important in Ayurveda and traditional Thai medicines. The saponin glycosides, shatavarin I and IV are major constituents in its roots and may be responsible for their actions including protection against lipid peroxidation and carcinogenesis. OBJECTIVE: To develop an immunoaffinity column for isolating compounds with structures related to shatavarin IV from crude extracts of A...
February 15, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28197856/determination-of-substrate-preferences-for-desaturases-and-elongases-for-production-of-docosahexaenoic-acid-from-oleic-acid-in-engineered-canola
#16
Jenny Lindberg Yilmaz, Ze Long Lim, Mirela Beganovic, Steven Breazeale, Carl Andre, Sten Stymne, Patricia Vrinten, Toralf Senger
Production of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in plant seed oils has been pursued to improve availability of these omega-3 fatty acids that provide important human health benefits. Canola (Brassica napus), through the introduction of 10 enzymes, can convert oleic acid (OLA) into EPA and ultimately DHA through a pathway consisting of two elongation and five desaturation steps. Herein we present an assessment of the substrate specificity of the seven desaturases and three elongases that were introduced into canola by expressing individual proteins in yeast...
February 14, 2017: Lipids
https://www.readbyqxmd.com/read/28197692/feasibility-of-establishing-an-australian-acl-registry-a-pilot-study-by-the-australian-orthopaedic-association-national-joint-replacement-registry-aoanjrr
#17
Christina Lekkas, Richard Clarnette, Stephen E Graves, Sophia Rainbird, David Parker, Michelle Lorimer, Roger Paterson, Justin Roe, Hayden Morris, Julian A Feller, Peter Annear, Ben Forster, David Hayes
PURPOSE: Rupture of the anterior cruciate ligament (ACL) is a common and debilitating injury that impacts significantly on knee function and risks the development of degenerative arthritis. The outcome of ACL surgery is not monitored in Australia. The optimal treatment is unknown. Consequently, the identification of best practice in treating ACL is crucial to the development of improved outcomes. The Australian Knee Society (AKS) asked the Australian Orthopaedic Association (AOA) to consider establishing a national ACL registry...
February 14, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28196022/proactive-versus-standard-percutaneous-catheter-drainage-for-infected-necrotizing-pancreatitis
#18
Janneke van Grinsven, Pieter Timmerman, Krijn P van Lienden, Jan Willem Haveman, Djamila Boerma, Casper H J van Eijck, Paul Fockens, Hjalmar C van Santvoort, Marja A Boermeester, Marc G Besselink
OBJECTIVES: Percutaneous catheter drainage (PCD) is often the first invasive treatment step for infected necrotizing pancreatitis. A proactive PCD strategy, including frequent and early drain revising and upsizing, may reduce the need for surgical necrosectomy and could improve outcomes, but data are lacking. METHODS: Necrotizing pancreatitis patients were identified from in-hospital databases (2004-2014). Patients with primary PCD for infected necrotizing pancreatitis were included...
February 14, 2017: Pancreas
https://www.readbyqxmd.com/read/28195217/lipid-droplet-dynamics-and-insulin-sensitivity-upon-a-5-day-high-fat-diet-in-caucasians-and-south-asians
#19
Anne Gemmink, Leontine E H Bakker, Bruno Guigas, Esther Kornips, Gert Schaart, A Edo Meinders, Ingrid M Jazet, Matthijs K C Hesselink
A 5-day High-Fat High-Calorie diet (HFHC-diet) reduces insulin-stimulated glucose disposal (Rd) in South Asian, but not Caucasian healthy lean males. We aimed to investigate if differences in myocellular lipid handling are underlying this differential response. A two-step hyperinsulinemic-euglycemic clamp and muscle biopsies were performed in 12 healthy lean Caucasian and South Asian males (BMI < 25 kg/m(2), 19-25 years) before and after a 5-day HFHC-diet (regular diet + 375 mL cream/day; 1275 kcal/day; 94% fat)...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194270/total-synthesis-of-a-key-series-of-vinblastines-modified-at-c4-that-define-the-importance-and-surprising-trends-in-activity
#20
Shouliang Yang, Kuppusamy Sankar, Colin K Skepper, Timothy J Barker, John C Lukesh, Daniel M Brody, Manuela M Brütsch, Dale L Boger
The total synthesis and evaluation of a key systematic series of vinblastines that incorporate the first deep-seated changes to the substituent at C4 are detailed. The synthetic approach features an expanded and redefined scope of a 1,3,4-oxadiazole [4 + 2]/[3 + 2] cycloaddition cascade in which electronically mismatched electron-deficient trisubstituted alkenes and unactivated trisubstituted alkenes were found to productively initiate the cycloaddition cascade with tethered electron-deficient 1,3,4-oxadiazoles...
February 1, 2017: Chemical Science
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