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UDP-Glycosyltransferases

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https://www.readbyqxmd.com/read/29775866/identification-of-udp-glucosyltransferases-from-the-aluminum-resistant-tree-eucalyptus-camaldulensis-forming-%C3%AE-glucogallin-the-precursor-of-hydrolyzable-tannins
#1
Ko Tahara, Mitsuru Nishiguchi, Andrej Frolov, Juliane Mittasch, Carsten Milkowski
In the highly aluminum-resistant tree Eucalyptus camaldulensis, hydrolyzable tannins are proposed to play a role in internal detoxification of aluminum, which is a major factor inhibiting plant growth on acid soils. To understand and modulate the molecular mechanisms of aluminum detoxification by hydrolyzable tannins, the biosynthetic genes need to be identified. In this study, we identified and characterized genes encoding UDP-glucose:gallate glucosyltransferase, which catalyzes the formation of 1-O-galloyl-β-d-glucose (β-glucogallin), the precursor of hydrolyzable tannins...
May 15, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29748819/recent-advances-in-steroidal-saponins-biosynthesis-and-in-vitro-production
#2
REVIEW
Swati Upadhyay, Gajendra Singh Jeena, Shikha, Rakesh Kumar Shukla
Steroidal saponins exhibited numerous pharmacological activities due to the modification of their backbone by different cytochrome P450s (P450) and UDP glycosyltransferases (UGTs). Plant-derived steroidal saponins are not sufficient for utilizing them for commercial purpose so in vitro production of saponin by tissue culture, root culture, embryo culture, etc, is necessary for its large-scale production. Saponin glycosides are the important class of plant secondary metabolites, which consists of either steroidal or terpenoidal backbone...
May 10, 2018: Planta
https://www.readbyqxmd.com/read/29744896/genes-for-seed-longevity-in-barley-identified-by-genomic-analysis-on-near-isogenic-lines
#3
Dorothee Wozny, Katharina Kramer, Iris Finkemeier, Ivan F Acosta, Maarten Koornneef
Genes controlling differences in seed longevity between two barley (Hordeum vulgare) accessions were identified by combining quantitative genetics 'omics' technologies in Near Isogenic Lines (NILs). The NILs were derived from crosses between the spring barley landraces L94 from Ethiopia and Cebada Capa from Argentina. A combined transcriptome and proteome analysis on mature, non-aged seeds of the two parental lines and the L94 NILs by RNA-sequencing and total seed proteomic profiling identified the UDP-glycosyltransferase MLOC_11661...
May 9, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29695246/transcriptomic-analysis-between-self-and-cross-pollinated-pistils-of-tea-plants-camellia-sinensis
#4
Qingping Ma, Changsong Chen, Zhongping Zeng, Zhongwei Zou, Huan Li, Qiongqiong Zhou, Xuan Chen, Kang Sun, Xinghui Li
BACKGROUND: Self-incompatibility (SI) is a major barrier that obstructs the breeding process in most horticultural plants including tea plants (Camellia sinensis). The aim of this study was to elucidate the molecular mechanism of SI in tea plants through a high throughput transcriptome analysis. RESULTS: In this study, the transcriptomes of self- and cross-pollinated pistils of two tea cultivars 'Fudingdabai' and 'Yulv' were compared to elucidate the SI mechanism of tea plants...
April 25, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29673318/genome-wide-analysis-of-family-1-udp-glycosyltransferases-ugt-and-identification-of-ugt-genes-for-fhb-resistance-in-wheat-triticum-aestivum-l
#5
Yi He, Dawood Ahmad, Xu Zhang, Yu Zhang, Lei Wu, Peng Jiang, Hongxiang Ma
BACKGROUND: Fusarium head blight (FHB), a devastating disease in wheat worldwide, results in yield loses and mycotoxin, such as deoxynivalenol (DON), accumulation in infected grains. DON also facilitates the pathogen colonization and spread of FHB symptoms during disease development. UDP-glycosyltransferase enzymes (UGTs) are known to contribute to detoxification and enhance FHB resistance by glycosylating DON into DON-3-glucoside (D3G) in wheat. However, a comprehensive investigation of wheat (Triticum aestivum) UGT genes is still lacking...
April 19, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29670540/thiamethoxam-resistance-in-aphis-gossypii-glover-relies-on-multiple-udp-glucuronosyltransferases
#6
Yiou Pan, Fayi Tian, Xiang Wei, Yongqiang Wu, Xiwu Gao, Jinghui Xi, Qingli Shang
Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are major phase II enzymes that conjugate a variety of small lipophilic molecules with UDP sugars and alter them into more water-soluble metabolites. Therefore, glucosidation plays a major role in the inactivation and excretion of a great variety of both endogenous and exogenous compounds. In this study, two inhibitors of UGT enzymes, sulfinpyrazone and 5-nitrouracil, significantly increased the toxicity of thiamethoxam against the resistant strain of Aphis gossypii , which indicates that UGTs are involved in thiamethoxam resistance in the cotton aphid...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29651019/author-correction-comparative-genomic-and-transcriptomic-analyses-of-family-1-udp-glycosyltransferase-in-three-brassica-species-and-arabidopsis-indicates-stress-responsive-regulation
#7
Hafiz Mamoon Rehman, Muhammad Amjad Nawaz, Zahid Hussain Shah, Jutta Ludwig-Müller, Gyuhwa Chung, Muhammad Qadir Ahmad, Seung Hwan Yang, Soo In Lee
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
April 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29608956/detection-and-validation-of-est-ssr-markers-associated-with-sugar-related-traits-in-sugarcane-using-linkage-and-association-mapping
#8
Kittipat Ukoskit, Ganlayarat Posudsavang, Nattapat Pongsiripat, Prasert Chatwachirawong, Peeraya Klomsa-Ard, Patthinun Poomipant, Somvong Tragoonrung
Sugar-related traits are of great importance in sugarcane breeding. In the present study, quantitative trait loci (QTL) mapping validated with association mapping was used to identify expressed sequence tag-simple sequence repeats (EST-SSRs) associated with sugar-related traits. For linkage mapping, 524 EST-SSRs, 241 Amplified Fragment Length Polymorphisms, and 10 genomic SSR markers were mapped using 283 F1 progenies derived from an interspecific cross. Six regions were identified using Multiple QTL Mapping, and 14 unlinked markers using single marker analysis...
March 31, 2018: Genomics
https://www.readbyqxmd.com/read/29603041/a-tandem-array-of-udp-glycosyltransferases-from-the-ugt73c-subfamily-glycosylate-sapogenins-forming-a-spectrum-of-mono-and-bisdesmosidic-saponins
#9
Pernille Østerbye Erthmann, Niels Agerbirk, Søren Bak
This study identifies six UGT73Cs all able to glucosylate sapogenins at positions 3 and/or 28 which demonstrates that B. vulgaris has a much richer arsenal of UGTs involved in saponin biosynthesis than initially anticipated. The wild cruciferous plant Barbarea vulgaris is resistant to some insects due to accumulation of two monodesmosidic triterpenoid saponins, oleanolic acid 3-O-β-cellobioside and hederagenin 3-O-β-cellobioside. Insect resistance depends on the structure of the sapogenin aglycone and the glycosylation pattern...
March 30, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29540192/udp-glycosyltransferase-genes-in-trypanosomatid-genomes-have-diversified-independently-to-meet-the-distinct-developmental-needs-of-parasite-adaptations
#10
Sara Silva Pereira, Andrew P Jackson
BACKGROUND: Trypanosomatid parasites such as Trypanosoma spp. and Leishmania spp. are a major source of infectious disease in humans and domestic animals worldwide. Fundamental to the host-parasite interactions of these potent pathogens are their cell surfaces, which are highly decorated with glycosylated proteins and other macromolecules. Trypanosomatid genomes contain large multi-copy gene families encoding UDP-dependent glycosyltransferases (UGTs), the primary role of which is cell-surface decoration...
March 14, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29484884/one-pot-synthesis-of-ginsenoside-rh2-and-bioactive-unnatural-ginsenoside-by-coupling-promiscuous-glycosyltransferase-from-bacillus-subtilis-168-to-sucrose-synthase
#11
Longhai Dai, Can Liu, Jiao Li, Caixia Dong, Jiangang Yang, Zhubo Dai, Xueli Zhang, Yuanxia Sun
Ginsenosides, the major effective ingredients of Panax ginseng, exhibit various biological properties. UDP-glycosyltransferase (UGT)-mediated glycosylation is the last biosynthetic step of ginsenosides and contributes to their immense structural and functional diversity. In this study, UGT Bs-YjiC from Bacillus subtilis 168 was demonstrated to transfer a glucosyl moiety to the free C3-OH and C12-OH of protopanaxadiol (PPD) and PPD-type ginsenosides to synthesize natural and unnatural ginsenosides. In vitro assays showed that unnatural ginsenoside F12 (3- O-β-d-glucopyranosyl-12- O-β-d-glucopyranosyl-20( S)-protopanaxadiol) exhibited remarkable activity against diverse human cancer cell lines...
March 21, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29483147/modulation-of-plant-salicylic-acid-associated-immune-responses-via-glycosylation-of-dihydroxybenzoic-acids
#12
Xu-Xu Huang, Guo-Qing Zhu, Qian Liu, Lu Chen, Yan-Jie Li, Bing-Kai Hou
Salicylic acid (SA) plays a crucial role in plant innate immunity. The deployment of SA-associated immune responses is primarily affected by SA concentration, which is determined by a balance between SA biosynthesis and catabolism. However, the mechanisms regulating SA homeostasis are poorly understood. In this study, we characterized a unique UDP-glycosyltransferase, UGT76D1, which plays an important role in SA homeostasis and associated immune responses in Arabidopsis ( Arabidopsis thaliana ). Expression of UGT76D1 was induced by treatment with both the pathogen Pseudomonas syringae pv...
April 2018: Plant Physiology
https://www.readbyqxmd.com/read/29463020/comparative-transcriptome-analysis-identifies-putative-genes-involved-in-dioscin-biosynthesis-in-dioscorea-zingiberensis
#13
Jia Li, Qin Liang, Changfu Li, Mengdi Liu, Yansheng Zhang
Dioscorea zingiberensis is a perennial herb native to China. The rhizome of D. zingiberensis has long been used as a traditional Chinese medicine to treat rheumatic arthritis. Dioscin is the major bioactive ingredient conferring the medicinal property described in Chinese pharmacopoeia. Several previous studies have suggested cholesterol as the intermediate to the biosynthesis of dioscin, however, the biosynthetic steps to dioscin after cholesterol remain unknown. In this study, a comprehensive D. zingiberensis transcriptome derived from its leaf and rhizome was constructed...
February 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29397056/identification-and-tissue-expression-profiling-of-candidate-udp-glycosyltransferase-genes-expressed-in-holotrichia-parallela-motschulsky-antennae
#14
S Wang, Y Liu, J-J Zhou, J-K Yi, Y Pan, J Wang, X-X Zhang, J-X Wang, S Yang, J-H Xi
It is difficult to control Holotrichia parallela Motschulsky with chemical insecticides due to the larvae's soil-living habit, thus the pest has caused great economic losses in agriculture. In addition, uridine diphosphate-glycosyltransferases (UGTs) catalyze the glycosylation process of a variety of small lipophilic molecules with sugars to produce water-soluble glycosides, and play multiple roles in detoxification, endobiotic modulation, and sequestration in an insect. Some UGTs were found specifically expressed in antennae of Drosophila melanogaster and Spodoptera littoralis, and glucurono-conjugated odorants could not elicit any olfactory signals, suggesting that the UGTs may play roles in odorant inactivation by biotransformation...
February 5, 2018: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/29382843/comparative-genomic-and-transcriptomic-analyses-of-family-1-udp-glycosyltransferase-in-three-brassica-species-and-arabidopsis-indicates-stress-responsive-regulation
#15
Hafiz Mamoon Rehman, Muhammad Amjad Nawaz, Zahid Hussain Shah, Jutta Ludwig-Müller, Gyuhwa Chung, Muhammad Qadir Ahmad, Seung Hwan Yang, Soo In Lee
In plants, UGTs (UDP-glycosyltransferases) glycosylate various phytohormones and metabolites in response to biotic and abiotic stresses. Little is known about stress-responsive glycosyltransferases in plants. Therefore, it is important to understand the genomic and transcriptomic portfolio of plants with regard to biotic and abiotic stresses. Here, we identified 140, 154, and 251 putative UGTs in Brassica rapa, Brassica oleracea, and Brassica napus, respectively, and clustered them into 14 major phylogenetic groups (A-N)...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29378087/advances-in-ginsenoside-biosynthesis-and-metabolic-regulation
#16
REVIEW
Jun Lu, Jinxin Li, Shihui Wang, Lu Yao, Wenxia Liang, Juan Wang, Wenyuan Gao
In this paper, we reviewed the advances in ginsenoside biosynthesis and metabolic regulation. To begin with, the application of elicitors in the ginsenoside biosynthesis was discussed. Methyl jasmonate (MJ) and analogues have the best effect on accumulation of ginsenoside compared with other elicitors, and few biotic elicitors are applied in Panax genus plants tissue culture. In addition, so far, more than 40 genes encoding ginsenoside biosynthesis related enzymes have been cloned and identified from Panax genus, such as UDP-glycosyltransferases (UGT) genes UDPG, UGTAE2, UGT94Q2, UGTPg100, and UGTPg1...
January 29, 2018: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/29372381/cloning-and-characterization-of-a-specific-udp-glycosyltransferase-gene-induced-by-don-and-fusarium-graminearum
#17
Lanfei Zhao, Xin Ma, Peisen Su, Wenyang Ge, Hongyan Wu, Xiuxiu Guo, Anfei Li, Hongwei Wang, Lingrang Kong
TaUGT5: can reduce the proliferation and destruction of F. graminearum and enhance the ability of FHB resistance in wheat. Deoxynivalenol (DON) is one of the most important toxins produced by Fusarium species that enhances the spread of the pathogen in the host. As a defense, the UDP-glycosyltransferase (UGT) family has been deduced to transform DON into the less toxic form DON-3-O-glucoside (D3G), but the specific gene member in wheat that is responsible for Fusarium head blight (FHB) resistance has been little investigated and proved...
April 2018: Plant Cell Reports
https://www.readbyqxmd.com/read/29372299/enzymatic-synthesis-of-avermectin-b-1a-glycosides-for-the-effective-prevention-of-the-pine-wood-nematode-bursaphelenchus-xylophilus
#18
Ha-Young Choi, Nguyen Van Minh, Jae Min Choi, Jae Yoon Hwang, Sang-Tae Seo, Seung-Kyu Lee, Won-Gon Kim
Avermectin produced by Streptomyces avermitilis is an anti-nematodal agent against the pine wood nematode Bursaphelenchus xylophilus. However, its potential usage is limited by its poor water solubility. For this reason, continuous efforts are underway to produce new derivatives that are more water soluble. Here, the enzymatic glycosylation of avermectin was catalyzed by uridine diphosphate (UDP)-glycosyltransferase from Bacillus licheniformis with various UDP sugars. As a result, the following four avermectin B1a glycosides were produced: avermectin B1a 4″-β-D-glucoside, avermectin B1a 4″-β-D-galactoside, avermectin B1a 4″-β-L-fucoside, and avermectin B1a 4″-β-2-deoxy-D-glucoside...
March 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29370751/association-mapping-for-total-polyphenol-content-total-flavonoid-content-and-antioxidant-activity-in-barley
#19
Zhigang Han, Jingjie Zhang, Shengguan Cai, Xiaohui Chen, Xiaoyan Quan, Guoping Zhang
BACKGROUND: The interest has been increasing on the phenolic compounds in plants because of their nutritive function as food and the roles regulating plant growth. However, their underlying genetic mechanism in barley is still not clear. RESULTS: A genome-wide association study (GWAS) was conducted for total phenolic content (TPC), total flavonoid content (FLC) and antioxidant activity (AOA) in 67 cultivated and 156 Tibetan wild barley genotypes. Most markers associated with phenolic content were different in cultivated and wild barleys...
January 25, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29357812/the-invasive-med-q-bemisia-tabaci-genome-a-tale-of-gene-loss-and-gene-gain
#20
Wen Xie, Xin Yang, Chunhai Chen, Zezhong Yang, Litao Guo, Dan Wang, Jinqun Huang, Hailin Zhang, Yanan Wen, Jinyang Zhao, Qingjun Wu, Shaoli Wang, Brad S Coates, Xuguo Zhou, Youjun Zhang
BACKGROUND: Sweetpotato whitefly, Bemisia tabaci MED/Q and MEAM1/B, are two economically important invasive species that cause considerable damages to agriculture crops through direct feeding and indirect vectoring of plant pathogens. Recently, a draft genome of B. tabaci MED/Q has been assembled. In this study, we focus on the genomic comparison between MED/Q and MEAM1/B, with a special interest in MED/Q's genomic signatures that may contribute to the highly invasive nature of this emerging insect pest...
January 22, 2018: BMC Genomics
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