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https://www.readbyqxmd.com/read/29187231/post-encephalitic-parkinsonism-following-dengue-viral-infection
#1
B V K M Bopeththa, U Ralapanawa
BACKGROUND: Incidence of dengue fever as well as dengue hemorrhagic fever is increasing in Sri Lanka especially among elderly population. As the number of cases is rising, rare complications of dengue illness also can be seen in clinical practice when compared to the past few years. Prompt identification and treatment of such complications is challenging due to lack of awareness and unavailability of standard treatment. CASE PRESENTATION: 69 years old man presented with acute onset fever and was diagnosed as having dengue illness...
November 29, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29175199/towards-a-neurodynamical-understanding-of-the-prodrome-in-schizophrenia
#2
REVIEW
E Mikanmaa, T Grent-'t-Jong, Hua Lingling, M Recasens, H Thune, Peter J Uhlhaas
The identification of biomarkers for the early diagnosis of schizophrenia that could inform novel treatment developments is an important objective of current research. This paper will summarize recent work that has investigated changes in oscillatory activity and event-related potentials with Electro/Magnetoencephalography (EEG/MEG) in participants at high-risk for the development of schizophrenia, highlighting disruptions in sensory and cognitive operations prior to the onset of the syndrome. Changes in EEG/MEG-data are consistent with evidence for alterations in Glutamatergic and GABAergic neurotransmission as disclosed by Magnetic Resonance Spectroscopy and brain stimulation, indicating changes in Excitation/Inhibition Parameters prior to the onset of psychosis...
November 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/29160912/low-sensitivity-and-frequent-cross-reactions-in-commercially-available-antibody-detection-elisa-assays-for-taenia-solium-cysticercosis
#3
Hector H Garcia, Yesenia Castillo, Isidro Gonzales, Javier A Bustos, Herbert Saavedra, Louis Jacob, Oscar H Del Brutto, Patricia P Wilkins, Armando E Gonzalez, Robert H Gilman
OBJECTIVE: To evaluate the diagnostic performance of two commercially available ELISA kits, Novalisa(®) and Ridascreen(®) , for the detection of antibodies to Taenia solium, compared to serological diagnosis of neurocysticercosis (NCC) by LLGP-EITB (electro immunotransfer blot assay using lentil-lectin purified glycoprotein antigens). METHODS: Archive serum samples from patients with viable NCC (n=45) or resolved, calcified NCC (n=45), as well as sera from patients with other cestode parasites (hymenolepiasis, n=45, and cystic hydatid disease, n=45), were evaluated for cysticercosis antibody detection using two ELISA kits, Novalisa(®) and Ridascreen(®) ...
November 21, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29150214/multifocal-best-s-disease-the-importance-of-genetic-tests
#4
C Alba Linero, M Rodríguez Calvo de Mora, M España Contreras, C Hernando Ayala
OBJECTIVES AND METHODS: Our objective is to describe a multifocal vitelliform presentation of Best's disease. The lesions in this disease may vary in size and shape, some may be a disc diameter in size, and often have some irregularity in their contour. The case is described of a 21-year-old male patient referred to our ophthalmology department due to a progressive loss of vision. His poor visual acuity was confirmed, and a complete examination was performed, in which macular flecks were observed, with yellow pigment arranged in oval distribution near their periphery...
November 14, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29144801/utility-of-a-single-late-night-plasma-cortisol-and-acth-for-the-diagnosis-of-cushing-s-syndrome
#5
Kush Dev Singh Jarial, Anil Bhansali, Kanchan K Mukherjee, Rimesh Pal, Akhilesh Sharma, Rakesh K Vashishtha, Suja P Sukumar, Naresh Sachdeva, Rama Walia
OBJECTIVE: To evaluate the diagnostic efficacy of various screening tests for the diagnosis of Cushing's syndrome (CS). METHODS: 35 patients of Cushing's syndrome and 16 patients of pseudo-Cushing's syndrome were enrolled. Assessment of 24h urinary free cortisol (UFC), late night salivary cortisol (LNSC), over night dexamethasone suppression test (ONDST), late night plasma cortisol (LNPC) and ACTH on outpatient basis, and during sleep as well as in awake state after 48 hours of hospital admission...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29075777/quantitative-autofluorescence-intensities-in-acute-zonal-occult-outer-retinopathy-vs-healthy-eyes
#6
Katherine Boudreault, Kaspar Schuerch, Jin Zhao, Winston Lee, Thiago Cabral, Lawrence A Yannuzzi, Stephen H Tsang, Janet R Sparrow
Importance: Acute zonal occult outer retinopathy (AZOOR) remains a challenging diagnosis. Early recognition of the disease depends on advances in imaging modalities that can improve phenotyping and contribute to the understanding of the underlying pathogenesis. Objectives: To expand the range of approaches available to assist in the identification of AZOOR by multimodal imaging and to analyze the fundus lesions by quantifying short-wavelength fundus autofluorescence (quantitative fundus autofluorescence [qAF]) and spectral-domain optical coherence tomography...
October 26, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29063767/detection-and-analysis-of-targeted-biological-cells-by-electrophoretic-coulter-method
#7
Yoshikata Nakajima, Tomofumi Ukai, Toshiaki Shimizu, Kazuhei Ogata, Seiki Iwai, Naohiro Takahashi, Atsushi Aki, Toru Mizuki, Toru Maekawa, Tatsuro Hanajiri
Combining the electrophoresis and conventional Coulter methods, we previously proposed the electrophoretic Coulter method (ECM), enabling simultaneous analysis of the size, number, and zeta potential of individual specimens. We validated the ECM experimentally using standard polystyrene particles and red blood cells (RBCs) from sheep; the latter was the first ECM application to biological particles in biotechnology research. However, specimens are prevented from passing through the ECM module aperture, which prevents accurate determination of the zeta potential of each specimen...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29026273/detection-of-early-stage-medullary-thyroid-carcinoma-by-measuring-serum-calcitonin-using-an-electro-chemiluminescence-immuno-assay-a-case-report-of-a-young-japanese-woman-with-a-high-risk-ret-mutation
#8
Yuki Abe, Shinya Tsukano
Medullary thyroid carcinoma (MTC) in multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disorder caused by the mutation of the RET proto-oncogene, that shows nearly complete penetration. The American Thyroid Association guidelines recommend prophylactic thyroidectomy for patients with high-risk RET mutations. However, in Japan, ethical and medical issues may preclude prophylactic treatment in young patients. Hence, an early diagnosis of MTC is necessary to ensure a favorable outcome. Here, we report the case of a young Japanese girl with a high-risk RET mutation, diagnosed with very early stage MTC using serum calcitonin (Ctn) values measured using an electro chemiluminescence immuno-assay (ECLIA)...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/28984246/the-role-of-eeg-in-the-diagnosis-and-classification-of-the-epilepsy-syndromes-a-tool-for-clinical-practice-by-the-ilae-neurophysiology-task-force-part-1
#9
Michalis Koutroumanidis, Alexis Arzimanoglou, Roberto Caraballo, Sushma Goyal, Anna Kaminska, Pramote Laoprasert, Hirokazu Oguni, Guido Rubboli, William Tatum, Pierre Thomas, Eugen Trinka, Luca Vignatelli, Solomon L Moshé
The concept of epilepsy syndromes, introduced in 1989, was defined as "clusters of signs and symptoms customarily occurring together". Definition of epilepsy syndromes based on electro-clinical features facilitated clinical practice and, whenever possible, clinical research in homogeneous groups of patients with epilepsies. Progress in the fields of neuroimaging and genetics made it rapidly clear that, although crucial, the electro-clinical description of epilepsy syndromes was not sufficient to allow much needed development of targeted therapies and a better understanding of the underlying pathophysiological mechanisms of seizures...
October 6, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28957618/quadrilateral-space-syndrome-treated-with-ultrasound-guided-corticosteroid-injection-a-case-of-isolated-teres-minor-atrophy-and-review-of-the-literature
#10
Peter S Chang, Nathan Jacobson, Kwang U Chang
Quadrilateral space syndrome (QSS) is a rare orthopedic condition caused by compression, entrapment, or injury to the axillary nerve or posterior humeral circumflex artery as they arise from the quadrilateral space. QSS can present with point tenderness over the quadrilateral space and weakness and paresthesia in the axillary nerve distribution. It is commonly associated with repetitive overhead activities and is seen in athletes engaging in such activities. Here we report a case of QSS in a 42-year-old male weight lifter who presented with pain and soreness in the posterior aspect of his right shoulder radiating around his arm as well as slight weakness of his right shoulder of a few weeks duration...
October 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28884317/relationship-of-very-low-serum-25-hydroxyvitamin-d3-levels-with-long-term-survival-in-a-large-cohort-of-colorectal-cancer-patients-from-germany
#11
Haifa Maalmi, Viola Walter, Lina Jansen, Jenny Chang-Claude, Robert W Owen, Alexis Ulrich, Ben Schöttker, Michael Hoffmeister, Hermann Brenner
To investigate the association of serum 25-hydroxyvitamin D (25(OH)D3) with survival in a large prospective cohort study of colorectal cancer (CRC) patients. The study population consisted of 2,910 patients diagnosed with CRC between 2003 and 2010 who participated in the DACHS study, a multicenter study from Germany with comprehensive long-term follow-up. 25(OH)D3 was determined in serum samples collected shortly after cancer diagnosis by High Performance Liquid Chromatography-Electro Spray Ionization-Mass Spectrometry...
November 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28880211/dual-mode-electro-optical-techniques-for-biosensing-applications-a-review
#12
REVIEW
José Juan-Colás, Steven Johnson, Thomas F Krauss
The monitoring of biomolecular interactions is a key requirement for the study of complex biological processes and the diagnosis of disease. Technologies that are capable of providing label-free, real-time insight into these interactions are of great value for the scientific and clinical communities. Greater understanding of biomolecular interactions alongside increased detection accuracy can be achieved using technology that can provide parallel information about multiple parameters of a single biomolecular process...
September 7, 2017: Sensors
https://www.readbyqxmd.com/read/28832375/contemporary-diagnosis-and-management-of-atrial-flutter-a-continuum-of-atrial-fibrillation-and-vice-versa
#13
Antonis S Manolis
Atrial flutter (AFlu) is usually a fast (>240 bpm) and regular right atrial macroreentrant tachycardia, with a constrained critical region of the reentry circuit located at the cavotricuspid isthmus (CTI; typical CTI-dependent AFlu). However, a variety of right and left atrial tachycardias, resulting from different mechanisms, can also present as AFlu (atypical non-CTI-dependent AFlu). The electrocardiogram can provide clues to its origin and location; however, additional entrainment and more sophisticated electroanatomical mapping techniques may be required to identify its mechanism, location, and target area for a successful ablation...
November 2017: Cardiology in Review
https://www.readbyqxmd.com/read/28773910/a-multi-level-decision-fusion-strategy-for-condition-based-maintenance-of-composite-structures
#14
Zahra Sharif Khodaei, M H Aliabadi
In this work, a multi-level decision fusion strategy is proposed which weighs the Value of Information (VoI) against the intended functions of a Structural Health Monitoring (SHM) system. This paper presents a multi-level approach for three different maintenance strategies in which the performance of the SHM systems is evaluated against its intended functions. Level 1 diagnosis results in damage existence with minimum sensors covering a large area by finding the maximum energy difference for the guided waves propagating in pristine structure and the post-impact state; Level 2 diagnosis provides damage detection and approximate localization using an approach based on Electro-Mechanical Impedance (EMI) measures, while Level 3 characterizes damage (exact location and size) in addition to its detection by utilising a Weighted Energy Arrival Method (WEAM)...
September 21, 2016: Materials
https://www.readbyqxmd.com/read/28752371/retinal-dystrophy-and-subretinal-drusenoid-deposits-in-female-choroideremia-carriers
#15
Vittoria Murro, Dario Pasquale Mucciolo, Ilaria Passerini, Simona Palchetti, Andrea Sodi, Gianni Virgili, Stanislao Rizzo
PURPOSE: To describe clinical and molecular characteristics in a group of Italian female choroideremia (CHM) carriers and report fundus patterns. METHODS: We retrospectively studied 11 female carriers belonging to six CHM families examined at the Regional Reference Center for Hereditary Retinal Degenerations at the Eye Clinic in Florence. We took into consideration patients with a comprehensive ophthalmological examination, fundus photography, optical coherence tomography (OCT), full field electro-retinography (ERG), and visual field (VF)...
November 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28729369/pigmentary-retinopathy-rod-cone-dysfunction-and-sensorineural-deafness-associated-with-a-rare-mitochondrial-trna-lys-m-8340g-a-gene-variant
#16
Jaidip S Gill, Steven A Hardy, Emma L Blakely, Sila Hopton, Andrea H Nemeth, Carl Fratter, Joanna Poulton, Robert W Taylor, Susan M Downes
BACKGROUND/AIM: The rare mitochondrial DNA (mtDNA) variant m.8340G>A has been previously reported in the literature in a single, sporadic case of mitochondrial myopathy. In this report, we aim to investigate the case of a 39-year-old male patient with sensorineural deafness who presented to the eye clinic with nyctalopia, retinal pigmentary changes and bilateral cortical cataracts. METHODS: The patient was examined clinically and investigated with autofluorescence, full-field electroretinography, electro-oculogram and dark adaptometry...
September 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28729098/a-multicentre-retrospective-review-of-clinical-characteristics-of-uterine-sarcoma
#17
Marta Wais, Elissa Tepperman, Marcus Q Bernardini, Lilian T Gien, Waldo Jimenez, Ally Murji
OBJECTIVE: Professional societies have recently urged gynaecologists to counsel patients about the risks of encountering uterine sarcoma at fibroid surgery especially when morcellation is used. Our objective was to learn the preoperative and postoperative characteristics of patients with uterine sarcoma to better counsel patients undergoing surgery for presumably benign fibroids. METHODS: This is a multicentre, retrospective cohort study. Three academic tertiary cancer centres in Southern Ontario over a 13-year period (2001-2014)...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28728299/-the-value-of-b7-h4-and-carcinoembryonic-antigen-in-diagnosing-the-benign-and-malignant-pleural-effusion
#18
F Wei, Y Wei, L F Li, G L Li, G J Wang
Objective: To evaluate the value of combined detection of negative costimulatory molecule B7-H4 and carcinoembryonic antigen (CEA) in diagnosing malignant and benign pleural effusion. Methods: Ninety-seven pleural effusion specimen were collected, 55 of which were diagnosed as malignant pleural effusion and 42 were benign pleural effusion. Enzyme-linked immunosorbent assay(ELISA) was used to examine the concentration of B7-H4 and CEA in pleural effusion. Electro-chemiluminescence immunoassay was used to detect the CEA level in pleural effusion...
July 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28719009/diagnosis-of-chronic-heart-failure-by-the-soluble-suppression-of-tumorigenicity-2-and-n-terminal-pro-brain-natriuretic-peptide
#19
Xiao-Ling Jin, Ning Huang, Hui Shang, Ming-Cheng Zhou, Yi Hong, Wen-Zheng Cai, Jie Huang
OBJECTIVE: Our study was to explore the roles between serum soluble suppression of tumorigenicity 2 (sST2) and N-terminal pro-brain natriuretic peptide (NT-proBNP) while evaluating ventricular function to properly diagnose chronic heart failure (CHF). METHODS: In total, 197 CHF patients were recruited and classified into ventricular function's II, III, and IV groups, and 106 healthy people into normal control group. To detect concentrations of Sst2 and NT-proBNP, ELISA and electro-chemiluminescence immuno assay were implemented...
July 18, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28687586/a-rash-with-a-heavy-heart
#20
Sergio Barros-Gomes, Niyada Naksuk, Dragan Jevremovic, Hector R Villarraga
Cardiac amyloidosis (CA) is relatively rare and frequently misdiagnosed. Other disorders presenting with increased left ventricular (LV) mass can mimic its diagnosis. This case illustrates unique findings of primary light chain (AL) amyloidosis in a patient with remarkable signs of CA. Here, we report a 49-year-old man with prior diagnosis of hypertrophy cardiomyopathy (HCM) based on an echocardiogram performed 1 year earlier that presented with 8 weeks of periorbital rash. He had numbness in the past 3 years...
July 7, 2017: Echo Research and Practice
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