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https://www.readbyqxmd.com/read/29914803/totally-laparoscopic-multi-stage-restorative-proctocolectomy-for-inflammatory-bowel-diseases-a-prospective-study-on-safety-efficacy-and-long-term-results
#1
Gianluca M Sampietro, Francesco Colombo, Alice Frontali, Caterina M Baldi, Stefania Carmagnola, Andrea Cassinotti, Alessandra Dell'Era, Alessandro Massari, Paola Molteni, Dario Dilillo, Paolo Fociani, Massimo Tonolini, Giovanni Maconi, Paolo Fiorina, Fabio Corsi, Roberto Bianco, Manuela Nebuloni, Gianvincenzo Zuccotti, Sandro Ardizzone, Diego Foschi
BACKGROUND: Laparoscopic ileo-pouch-anal anastomosis (IPAA) has been reported as having low morbidity and several advantages. AIMS: To evaluate safety, efficacy and long-term results of laparoscopic IPAA, performed in elective or emergency settings, in consecutive unselected IBD patients. METHODS: All the patients received totally laparoscopic 2-stage (proctocolectomy and IPAA - stoma closure) or 3-stage (colectomy - proctectomy and IPAA - stoma closure) procedure according to their presentation...
May 21, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29893990/body-height-in-pediatric-ibd-a-structural-equation-model-analysis
#2
Giorgos Chouliaras, Aimilia Mantzou, Daphne Margoni, Nikolaos Tsilifis, Panagiota Pervanidou, Ioanna Panayotou, Christina Kanaka-Gantenbein, George P Chrousos, Eleftheria Roma-Giannikou
BACKGROUND: Linear growth restriction is a unique feature of pediatric inflammatory bowel diseases (IBD) and reduced insulin-like growth factor (IGF-1) is a major determinant of short stature. We aimed to assess factors influencing somatic height in children suffering from IBD. MATERIALS AND METHODS: This was a retrospective, cross-sectional study conducted after approval by Institutional authorities. Anthropometric data, disease-related factors, biochemical and clinical indices of inflammation and endocrine parameters were recorded and considered as explanatory covariates...
June 12, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29890970/escherichia-coli-b2-strains-prevalent-in-inflammatory-bowel-disease-patients-have-distinct-metabolic-capabilities-that-enable-colonization-of-intestinal-mucosa
#3
Xin Fang, Jonathan M Monk, Nathan Mih, Bin Du, Anand V Sastry, Erol Kavvas, Yara Seif, Larry Smarr, Bernhard O Palsson
BACKGROUND: Escherichia coli is considered a leading bacterial trigger of inflammatory bowel disease (IBD). E. coli isolates from IBD patients primarily belong to phylogroup B2. Previous studies have focused on broad comparative genomic analysis of E. coli B2 isolates, and identified virulence factors that allow B2 strains to reside within human intestinal mucosa. Metabolic capabilities of E. coli strains have been shown to be related to their colonization site, but remain unexplored in IBD-associated strains...
June 11, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29889230/sarcopenia-and-inflammatory-bowel-disease-a-systematic-review
#4
Eanna Ryan, Daniel McNicholas, Ben Creavin, Michael Eamon Kelly, Tom Walsh, David Beddy
Background: Sarcopenia is associated with increased morbidity and mortality in oncologic and transplant surgery. It has a high incidence in chronic inflammatory states including inflammatory bowel disease (IBD). The validity of existing data in IBD and of sarcopenia's correlation with surgical outcomes is limited. Methods: We performed a systematic review to assess the correlation of sarcopenia with the requirement for surgery and surgical outcomes in patients with IBD...
June 7, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29851767/management-of-paediatric-ulcerative-colitis-part-2-acute-severe-colitis-an-evidence-based-consensus-guideline-from-ecco-and-espghan
#5
Dan Turner, Frank M Ruemmele, Esther Orlanski-Meyer, Anne M Griffiths, Javier Martin de Carpi, Jiri Bronsky, Gabor Veres, Marina Aloi, Caterina Strisciuglio, Christian P Braegger, Amit Assa, Claudio Romano, Séamus Hussey, Michael Stanton, Mikko Pakarinen, Lissy de Ridder, Konstantinos H Katsanos, Nick Croft, Víctor Manuel Navas-López, David C Wilson, Sally Lawrence, Richard K Russell
BACKGROUND AND AIM: Acute severe colitis (ASC) is one of the few emergencies in paediatric gastroenterology. Tight monitoring and timely medical and surgical interventions may improve outcomes and minimize morbidity and mortality. We aimed to standardize daily treatment of ASC in children through detailed recommendations and practice points which are based on a systematic review of the literature and consensus of experts. METHODS: These guidelines are a joint effort of the European Crohn's and Colitis Organization (ECCO) and the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)...
May 30, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29851766/management-of-paediatric-ulcerative-colitis-part-1-ambulatory-care-an-evidence-based-guideline-from-ecco-and-espghan
#6
Dan Turner, Frank M Ruemmele, Esther Orlanski-Meyer, Anne M Griffiths, Javier Martin de Carpi, Jiri Bronsky, Gabor Veres, Marina Aloi, Caterina Strisciuglio, Christian P Braegger, Amit Assa, Claudio Romano, Séamus Hussey, Michael Stanton, Mikko Pakarinen, Lissy de Ridder, Konstantinos Katsanos, Nick Croft, Victor Navas-López, David C Wilson, Sally Lawrence, Richard K Russell
BACKGROUND: The contemporary management of ambulatory ulcerative colitis (UC) continues to be challenging with ∼20% of children needing a colectomy within childhood years. We thus aimed to standardize daily treatment of paediatric UC and inflammatory bowel diseases (IBD)-unclassified through detailed recommendations and practice points. METHODS: These guidelines are a joint effort of the European Crohn's and Colitis Organization (ECCO) and the Paediatric IBD Porto group of European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)...
May 30, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29777041/evolving-role-of-diet-in-the-pathogenesis-and-treatment-of-inflammatory-bowel-diseases
#7
REVIEW
Arie Levine, Rotem Sigall Boneh, Eytan Wine
Recent advances in basic and clinical science over the last 3 years have dramatically altered our appreciation of the role of diet in inflammatory bowel diseases (IBD). The marked increase in incidence of these diseases along with the important role of non-genetic susceptibility among patients with IBD has highlighted that these diseases have a strong environmental component. Progress in the field of microbiome and IBD has demonstrated that microbiome appears to play an important role in pathogenesis, and that diet may in turn impact the composition and functionality of the microbiome...
May 18, 2018: Gut
https://www.readbyqxmd.com/read/29754190/allergic-and-immunologic-perspectives-of-inflammatory-bowel-disease
#8
REVIEW
Kofi Clarke, Jayakrishna Chintanaboina
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory condition primarily involving the gastrointestinal tract. It includes Crohn's disease (CD), ulcerative colitis (UC), and a less common phenotype-indeterminate colitis. It is thought to result from a complex interplay of environmental, microbial, and host factors including genetic factors, although the exact mechanism is not known. Dietary factors have been shown to play a role in the pathogenesis of IBD and can potentially alter the intestinal microbiota as well as disrupt the immune function in the gut...
May 12, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29718370/pediatric-inflammatory-bowel-diseases-should-we-be-looking-for-kidney-abnormalities
#9
Didde Lauritzen, Bente Utoft Andreassen, Niels Henrik H Heegaard, Lone Gabriels Klinge, Anne-Mette Walsted, Mette Neland, Rasmus Gaardskær Nielsen, Per Wittenhagen
Background: Kidney disease has been reported in adults with inflammatory bowel disease (IBD) and is regarded an extraintestinal manifestation or more rarely a side effect of the medical treatment. Methods: In this cross-sectional study we describe the extent of kidney pathology in a cohort of 56 children with IBD. Blood and urine samples were analyzed for markers of kidney disease and ultrasonography was performed to evaluate pole-to-pole kidney length. Results: We found that 25% of the patients had either previously reported kidney disease or ultrasonographic signs of chronic kidney disease...
April 26, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29697827/diet-and-anthropometrics-of-children-with-inflammatory-bowel-disease-a-comparison-with-the-general-population
#10
Kay Diederen, Hilde Krom, Jeffrey C D Koole, Marc A Benninga, Angelika Kindermann
Background: There is a lack of knowledge regarding the diet of children with inflammatory bowel disease (IBD). Therefore, we investigated dietary intake in pediatric IBD compared to the general population and assessed anthropometrics and food avoidance. Methods: In this cross-sectional cohort study, patients younger than 18 years with IBD were included (2014-2017). Dietary intake (total energy, macro nutrients, food types) was assessed using a Food Frequency Questionnaire (FFQ) and compared with a matched reference population (n = 306)...
April 25, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29693729/inflammatory-bowel-disease-and-immunonutrition-novel-therapeutic-approaches-through-modulation-of-diet-and-the-gut-microbiome
#11
REVIEW
Larissa S Celiberto, Franziska A Graef, Genelle R Healey, Else S Bosman, Kevan Jacobson, Laura M Sly, Bruce A Vallance
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, thought to at least in part reflect an aberrant immune response to gut bacteria. IBD is increasing in incidence, particularly in populations that have recently immigrated to western countries. This suggests that environmental factors are involved in its pathogenesis. We hypothesize that the increase in IBD rates might reflect the consumption of an unhealthy Western diet, containing excess calories and lacking in key nutritional factors, such as fibre and vitamin D...
April 25, 2018: Immunology
https://www.readbyqxmd.com/read/29675025/impact-of-paneth-cell-autophagy-on-inflammatory-bowel-disease
#12
REVIEW
Shu-Ling Wang, Bo-Zong Shao, Sheng-Bing Zhao, Jun Fang, Lun Gu, Chao-Yu Miao, Zhao-Shen Li, Yu Bai
Intestinal mucosal barrier, mainly consisting of the mucus layer and epithelium, functions in absorbing nutrition as well as prevention of the invasion of pathogenic microorganisms. Paneth cell, an important component of mucosal barrier, plays a vital role in maintaining the intestinal homeostasis by producing antimicrobial materials and controlling the host-commensal balance. Current evidence shows that the dysfunction of intestinal mucosal barrier, especially Paneth cell, participates in the onset and progression of inflammatory bowel disease (IBD)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29673210/bioelectrical-impedance-phase-angle-as-an-indicator-of-malnutrition-in-hospitalized-children-with-diagnosed-inflammatory-bowel-diseases-a-case-control-study
#13
Paweł Więch, Mariusz Dąbrowski, Dariusz Bazaliński, Izabela Sałacińska, Bartosz Korczowski, Monika Binkowska-Bury
The phase angle (PhA) seems to be a reliable screening tool for the identification of malnutrition risk in hospitalized children with inflammatory bowel disease (IBD). The aim of the present study was to assess the body composition and nutritional status of hospitalized children and adolescents with IBD by using bioelectrical impedance analysis (BIA) with phase angle (PhA) calculation, which has not been evaluated in hospitalized children with IBD yet. A total of 59 children and adolescents aged 4–18 years, with IBD: 34 ulcerative colitis (UC) and 25 Crohn’s disease (CD) were included in the study...
April 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29619131/maintenance-of-intestinal-homeostasis-by-mucosal-barriers
#14
REVIEW
Ryu Okumura, Kiyoshi Takeda
Background: The intestine is inhabited by a tremendous number of microorganisms, which provide many benefits to nutrition, metabolism and immunity. Mucosal barriers by intestinal epithelial cells make it possible to maintain the symbiotic relationship between the gut microbiota and the host by separating them. Recent evidence indicates that mucosal barrier dysfunction contributes to the development of inflammatory bowel disease (IBD). In this review, we focus on the mechanisms by which mucosal barriers maintain gut homeostasis...
2018: Inflammation and Regeneration
https://www.readbyqxmd.com/read/29570147/nutrition-in-pediatric-inflammatory-bowel-disease-a-position-paper-on-behalf-of-the-porto-inflammatory-bowel-disease-group-of-the-european-society-of-pediatric-gastroenterology-hepatology-and-nutrition
#15
Erasmo Miele, Raanan Shamir, Marina Aloi, Amit Assa, Christian Braegger, Jiri Bronsky, Lissy de Ridder, Johanna C Escher, Iva Hojsak, Sanja Kolaček, Sibylle Koletzko, Arie Levine, Paolo Lionetti, Massimo Martinelli, Frank Ruemmele, Richard K Russell, Rotem Sigall Boneh, Johan van Limbergen, Gigi Veereman, Annamaria Staiano
BACKGROUND AND AIMS: A growing body of evidence supports the need for detailed attention to nutrition and diet in children with inflammatory bowel disease (IBD). We aimed to define the steps in instituting dietary or nutritional management in light of the current evidence and to offer a useful and practical guide to physicians and dieticians involved in the care of pediatric IBD patients. METHODS: A group of 20 experts in pediatric IBD participated in an iterative consensus process including 2 face-to-face meetings, following an open call to Nutrition Committee of the European Society of Pediatric Gastroenterology, Hepatology and Nutrition Porto, IBD Interest, and Nutrition Committee...
April 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29563038/clinical-manifestations-pathophysiology-treatment-and-outcome-of-inflammatory-bowel-diseases-in-older-people
#16
REVIEW
Matthias Butter, Stefan Weiler, Luc Biedermann, Michael Scharl, Gerhard Rogler, Heike A Bischoff-Ferrari, Benjamin Misselwitz
Approximately 10-20% of inflammatory bowel disease (IBD) cases are diagnosed after 60 years of age. Due to the high prevalence of conditions mimicking IBD at older age - including bowel disease associated with non-steroidal anti-inflammatory drugs, diverticulitis, and microscopic colitis - differential diagnosis of IBD among older adults is frequently delayed. Late-onset IBD is characterized by a predominance of colonic disease and an overall milder disease course; disease progression and new intestinal manifestations are rare...
April 2018: Maturitas
https://www.readbyqxmd.com/read/29549916/comprehensive-genetic-study-of-fatty-acids-helps-explain-the-role-of-noncoding-inflammatory-bowel-disease-associated-snps-and-fatty-acid-metabolism-in-disease-pathogenesis
#17
Gregor Jezernik, Uroš Potočnik
Fatty acids and their derivatives play an important role in inflammation. Diet and genetics influence fatty acid profiles. Abnormalities of fatty acid profiles have been observed in inflammatory bowel diseases (IBD), a group of complex diseases defined by chronic gastrointestinal inflammation. IBD associated fatty acid profile abnormalities were observed independently of nutritional status or disease activity, suggesting a common genetic background. However, no study so far has attempted to look for overlap between IBD loci and fatty acid associated loci or investigate the genetics of fatty acid profiles in IBD...
March 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29543696/global-variation-in-use-of-enteral-nutrition-for-pediatric-crohn-disease
#18
Morgan Lawley, Jessica W Wu, Victor M Navas-López, Hien Q Huynh, Matthew W Carroll, Min Chen, Pavel Medvedev, Andrew S Day, Séamus Hussey, Rotem Sigall-Boneh, Arie Levine, Eytan Wine
OBJECTIVES: Exclusive enteral nutrition (EEN) is an effective induction treatment for pediatric Crohn disease. Given the center-based variation in use and diversity in practice we constructed a survey aimed at sharing experience and strategies in administering EEN, stimulating further research, and optimizing therapy. METHODS: This survey was constructed after consultation with experts and designed to address key knowledge gaps. The survey was disseminated through the Paediatric IBD Porto Group of ESPGHAN, Canadian Children IBD Network, selective experts, and was sent twice through the PEDGI-BB...
March 14, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29531465/quality-indicators-in-pediatric-colonoscopy-in-a-low-volume-center-implications-for-training
#19
Way-Seah Lee, Chun-Wei Tee, Zhong-Lin Koay, Tat-Seng Wong, Fatimah Zahraq, Hee-Wei Foo, Sik-Yong Ong, Shin-Yee Wong, Ruey-Terng Ng
AIM: To study implications of measuring quality indicators on training and trainees' performance in pediatric colonoscopy in a low-volume training center. METHODS: We reviewed retrospectively the performance of pediatric colonoscopies in a training center in Malaysia over 5 years (January 2010-December 2015), benchmarked against five quality indicators: appropriateness of indications, bowel preparations, cecum and ileal examination rates, and complications. The European Society of Gastrointestinal Endoscopy guideline for pediatric endoscopy and North American Society for Pediatric Gastroenterology, Hepatology and Nutrition training guidelines were used as benchmarks...
March 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29462382/prediagnostic-serum-vitamin-d-levels-and-the-risk-of-crohn-s-disease-and-ulcerative-colitis-in-european-populations-a-nested-case-control-study
#20
Jorrit L Opstelten, Simon S M Chan, Andrew R Hart, Fiona D M van Schaik, Peter D Siersema, Eef G W M Lentjes, Kay-Tee Khaw, Robert Luben, Timothy J Key, Heiner Boeing, Manuela M Bergmann, Kim Overvad, Domenico Palli, Giovanna Masala, Antoine Racine, Franck Carbonnel, Marie-Christine Boutron-Ruault, Anne Tjønneland, Anja Olsen, Vibeke Andersen, Rudolf Kaaks, Tilman Kühn, Rosario Tumino, Antonia Trichopoulou, Petra H M Peeters, W M Monique Verschuren, Ben J M Witteman, Bas Oldenburg
Background: A low vitamin D status has been put forward as a potential risk factor for the development of inflammatory bowel disease (IBD). This study investigated the association between prediagnostic circulating vitamin D concentrations and dietary intakes of vitamin D, and the risk of Crohn's disease (CD) and ulcerative colitis (UC). Methods: Among 359,728 participants of the European Prospective Investigation into Cancer and Nutrition cohort, individuals who developed CD or UC after enrollment were identified...
February 15, 2018: Inflammatory Bowel Diseases
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