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https://www.readbyqxmd.com/read/27899522/care-of-inflammatory-bowel-disease-patients-in-remission
#1
REVIEW
Charumathi Raghu Subramanian, George Triadafilopoulos
Inflammatory bowel disease (IBD) comprises two distinct conditions: ulcerative colitis and Crohn's disease, both of which are chronic, relapsing disorders carrying significant morbidity, mortality and healthcare costs. With growing attention to coordinated healthcare for patients with chronic systemic diseases, this review focuses on the care of IBD patients in remission, their concerns, quality of life, follow-up, the role of primary care physicians and the IBD-specific aspects of long-term care. We did an extensive PubMed search for articles pertaining to IBD patients in remission and, along with the authors' experience, formulated a comprehensive review...
November 2016: Gastroenterology Report
https://www.readbyqxmd.com/read/27801750/perianal-crohn-s-disease-in-a-large-multicenter-pediatric-collaborative
#2
Jeremy Adler, Shiming Dong, Sally J Eder, Kevin J Dombkowski
BACKGROUND: Although perianal complications of Crohn's disease (CD) are commonly encountered in clinical practice, the epidemiology of perianal CD among populations of children is poorly understood. We sought to characterize the prevalence of perianal disease in a large and diverse population of pediatric CD patients. METHODS: We conducted retrospective analyses from a prospective observational cohort, the ImproveCareNow Network (May 2006-October 2014), a multicenter pediatric inflammatory bowel disease quality improvement collaborative...
October 31, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27782961/using-the-objective-structured-clinical-exam-osce-to-assess-acgme-competencies-in-pediatric-gastroenterology-fellows
#3
Aliza B Solomon, Rachel Reed, Keith Benkov, Joseph Kingsbery, Sarah S Lusman, Lisa B Malter, Jeremiah Levine, Simon Rabinowitz, Martin Wolff, Sondra Zabar, Elizabeth Weinshel
BACKGROUND: The Accreditation Council for Graduate Medical Education (ACGME) has described six core competencies with which trainees should demonstrate proficiency. Using the Objective Structured Clinical Exam (OSCE), we aimed to assess four of these competencies among Pediatric GI fellows (PG). METHODS: Eight first-year PG's from six medical centers in the New York area participated in a four-station OSCE with trained standardized patient (SP) actors. The cases included an "ED Consult" for lower GI bleeding; "Breaking Bad News" focusing on CF nutritional complications; "Second Opinion" for abdominal pain; "Transition of Care" for inflammatory bowel disease...
October 25, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27775675/why-are-omics-technologies-important-to-understanding-the-role-of-nutrition-in-inflammatory-bowel-diseases
#4
Lynnette R Ferguson, Matthew P G Barnett
For many years, there has been confusion about the role that nutrition plays in inflammatory bowel diseases (IBD). It is apparent that good dietary advice for one individual may prove inappropriate for another. As with many diseases, genome-wide association studies across large collaborative groups have been important in revealing the role of genetics in IBD, with more than 200 genes associated with susceptibility to the disease. These associations provide clues to explain the differences in nutrient requirements among individuals...
October 21, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27769076/the-role-of-dietary-supplements-in-inflammatory-bowel-disease-a-systematic-review
#5
Roberta E Rossi, Tara Whyand, Charles D Murray, Mark I Hamilton, Dario Conte, Martyn E Caplin
Inflammatory bowel diseases (IBD) are chronic immune disorders of unclear aetiology. Dietary deficiencies may be a potential pathogenic factor in their development. Patients often take food supplements without knowledge of any evidence base. We have therefore assessed the evidence for food supplementation in the management of IBD. A PubMed search was performed for the terms Inflammatory bowel disease; nutritional deficiencies; dietary supplements; curcumin; green tea; vitamin D/other vitamins; folic acid; iron; zinc; probiotics; andrographis paniculata; and boswellia serrate...
December 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27760077/the-gut-microbiome-of-pediatric-crohn-s-disease-patients-differs-from-healthy-controls-in-genes-that-can-influence-the-balance-between-a-healthy-and-dysregulated-immune-response
#6
Katherine A Dunn, Jessica Moore-Connors, Brad MacIntyre, Andrew Stadnyk, Nikhil A Thomas, Angela Noble, Gamal Mahdi, Mohsin Rashid, Anthony R Otley, Joseph P Bielawski, Johan Van Limbergen
BACKGROUND: Exclusive enteral nutrition (EEN) is a first-line therapy in pediatric Crohn's disease (CD) thought to induce remission through changes in the gut microbiome. With microbiome assessment largely focused on microbial taxonomy and diversity, it remains unclear to what extent EEN induces functional changes that thereby contribute to its therapeutic effect. METHODS: Fecal samples were collected from 15 pediatric CD patients prior to and after EEN treatment, as well as from 5 healthy controls...
November 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27743467/therapeutic-modulation-of-the-gut-microbiota-in-ibd-more-questions-to-be-answered
#7
Yu Qi Qiao, Chen Wen Cai, Zhi Hua Ran
Inflammatory bowel disease (IBD) patients exhibit impaired control of the microbiome in the gut. "Dysbiosis" is commonly observed. A Western diet is a risk factor for the development of IBD but may have different effects on the gut microbiota in IBD and non-IBD individuals. Exclusive enteral nutrition (EEN) can induce remission in pediatric Crohn's disease (CD) with a decrease in gut microbiome diversity after EEN treatment. Although there are some theoretical benefits, the actual treatment effects of prebiotics and probiotics in IBD patients can vary...
October 15, 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27681914/microbiome-metabolome-and-inflammatory-bowel-disease
#8
REVIEW
Ishfaq Ahmed, Badal C Roy, Salman A Khan, Seth Septer, Shahid Umar
Inflammatory Bowel Disease (IBD) is a multifactorial disorder that conceptually occurs as a result of altered immune responses to commensal and/or pathogenic gut microbes in individuals most susceptible to the disease. During Crohn's Disease (CD) or Ulcerative Colitis (UC), two components of the human IBD, distinct stages define the disease onset, severity, progression and remission. Epigenetic, environmental (microbiome, metabolome) and nutritional factors are important in IBD pathogenesis. While the dysbiotic microbiota has been proposed to play a role in disease pathogenesis, the data on IBD and diet are still less convincing...
June 15, 2016: Microorganisms
https://www.readbyqxmd.com/read/27677691/bone-status-assessed-by-quantitative-ultrasound-in-children-with-inflammatory-bowel-disease-a-comparison-with-dxa
#9
Katarzyna Bąk-Drabik, Piotr Adamczyk, Agata Chobot, Jarosław Kwiecień, Wojciech Pluskiewicz
BACKGROUND: To determine the bone status in children with inflammatory bowel diseases (IBD) using quantitative ultrasound (QUS) measurement at hand phalanges and compare the obtained results with dual-energy X-ray absorptiometry (DXA). METHODS: Fifty-one children with IBD underwent DXA and QUS measurements at hand phalanges in the year 2013. The control group for the QUS consisted of 460 children. Reference data for DXA comes from Hologic Explorer. RESULTS: QUS measurements did not differ significantly between IBD patients and healthy controls...
October 11, 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27673381/translating-nutritional-immunology-into-drug-development-for-inflammatory-bowel-disease
#10
Andrew Leber, Raquel Hontecillas, Nuria Tubau-Juni, Josep Bassaganya-Riera
PURPOSE OF REVIEW: To highlight recent advances in the understanding of nutritional immunology and in the development of novel therapeutics for inflammatory bowel disease (IBD). RECENT FINDINGS: We highlight the variety of factors that contribute to the interaction of the immune system and nutrition including the microbiome and the nervous system stimulation of the gut. We describe the potential for therapeutic development in IBD. Further, we review the cellular metabolic effects on immune activation and promising therapeutic targets...
November 2016: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/27637649/nutritional-strategies-in-the-management-of-adult-patients-with-inflammatory-bowel-disease-dietary-considerations-from-active-disease-to-disease-remission
#11
REVIEW
Douglas L Nguyen, Berkeley Limketkai, Valentina Medici, Mardeli Saire Mendoza, Lena Palmer, Matthew Bechtold
Inflammatory bowel disease (IBD) is a group of chronic, lifelong, and relapsing illnesses, such as ulcerative colitis and Crohn's disease, which involve the gastrointestinal tract. There is no cure for these diseases, but combined pharmacological and nutritional therapy can induce remission and maintain clinical remission. Malnutrition and nutritional deficiencies among IBD patients result in poor clinical outcomes such as growth failure, reduced response to pharmacotherapy, increased risk for sepsis, and mortality...
October 2016: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/27634305/is-modern-medical-management-changing-ultimate-patient-outcomes-in-inflammatory-bowel-disease
#12
Quinton M Hatch, Rubina Ratnaparkhi, Alison Althans, Michael Keating, Ruel Neupane, Madhuri Nishtala, Eric K Johnson, Scott R Steele
BACKGROUND: The impact of modern medical management of inflammatory bowel disease (IBD) on surgical necessity and outcomes remains unclear. We hypothesized that surgery rates have decreased while outcomes have worsened due to operating on "sicker" patients since the introduction of biologic medications. METHODS: The Nationwide Inpatient Sample and ICD-9-CM codes were used to identify inpatient admissions for Crohn's disease and ulcerative colitis. Trends in IBD nutrition, surgeries, and postoperative complications were determined...
September 15, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27622898/pediatric-gastrointestinal-endoscopy-european-society-of-pediatric-gastroenterology-hepatology-and-nutrition-espghan-and-european-society-of-gastrointestinal-endoscopy-esge-guidelines
#13
Mike Thomson, Andrea Tringali, Rosario Landi, Jean-Marc Dumonceau, Marta Tavares, Jorge Amil-Dias, Marc Benninga, Merit M Tabbers, Raoul Furlano, Manon Spaander, Cesare Hassan, Christos Tzvinikos, Hanneke Ijsselstijn, Jérôme Viala, Luigi Dall'Oglio, Rok Orel, Yvan Vandenplas, Radan Keil, Štěpán Hlava, Claudio Romano, Eva Brownstone, Patrick Gerner, Werner Dolak, Wolf Dietrich Huber, Simon Everett, Andreas Vecsei, Lars Aabakken, Alessandro Zambelli
This Guideline refers to infants, children and adolescents aged 0-18 years. The areas covered include: indications for diagnostic and therapeutic esophagogastroduodenoscopy and ileo-colonoscopy; endoscopy for foreign body ingestion; corrosive ingestion and stricture/stenosis endoscopic management; upper and lower gastrointestinal bleeding; endoscopic retrograde cholangio-pancreatography and endoscopic ultrasonography. Percutaneous endoscopic gastrostomy and endoscopy specific to inflammatory bowel disease (IBD) has been dealt with in other Guidelines [1-3] and are therefore not mentioned in this Guideline...
September 12, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27617420/pediatric-gastrointestinal-endoscopy-european-society-of-gastrointestinal-endoscopy-esge-and-european-society-for-paediatric-gastroenterology-hepatology-and-nutrition-espghan-guideline-executive-summary
#14
Andrea Tringali, Mike Thomson, Jean-Marc Dumonceau, Marta Tavares, Merit M Tabbers, Raoul Furlano, Manon Spaander, Cesare Hassan, Christos Tzvinikos, Hanneke Ijsselstijn, Jérôme Viala, Luigi Dall'Oglio, Marc Benninga, Rok Orel, Yvan Vandenplas, Radan Keil, Claudio Romano, Eva Brownstone, Štěpán Hlava, Patrick Gerner, Werner Dolak, Rosario Landi, Wolf Dietrich Huber, Simon Everett, Andreas Vecsei, Lars Aabakken, Jorge Amil-Dias, Alessandro Zambelli
This Executive summary of the Guideline on pediatric gastrointestinal endoscopy from the European Society of Gastrointestinal Endoscopy (ESGE) and the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) refers to infants, children, and adolescents aged 0 - 18 years. The areas covered include: indications for diagnostic and therapeutic esophagogastroduodenoscopy and ileocolonoscopy; endoscopy for foreign body ingestion; endoscopic management of corrosive ingestion and stricture/stenosis; upper and lower gastrointestinal bleeding; endoscopic retrograde cholangiopancreatography, and endoscopic ultrasonography...
September 12, 2016: Endoscopy
https://www.readbyqxmd.com/read/27602237/infertility-in-men-with-inflammatory-bowel-disease
#15
REVIEW
Takeshi Shin, Hiroshi Okada
Inflammatory bowel disease (IBD) predominantly affects young adults. Fertility-related issues are therefore important in the management of patients with IBD. However, relatively modest attention has been paid to reproductive issues faced by men with IBD. To investigate the effects of IBD and its treatment on male fertility, we reviewed the current literature using a systematic search for published studies. A PubMed search were performed using the main search terms "IBD AND male infertility", "Crohn's disease AND male infertility", "ulcerative colitis AND male infertility"...
August 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27598738/knowledge-attitudes-and-beliefs-regarding-the-role-of-nutrition-in-ibd-among-patients-and-providers
#16
Andrew Tinsley, Orna G Ehrlich, Caroline Hwang, Kelly Issokson, Sophia Zapala, Alandra Weaver, Corey A Siegel, Gil Y Melmed
BACKGROUND: Malnutrition is common in inflammatory bowel disease (IBD). Identifying patients who are malnourished or at risk for malnutrition may lead to early intervention and improve patient outcomes. To date, little is known about the role of nutritional assessment and management in IBD care. We aimed to evaluate knowledge, attitudes, and beliefs regarding nutrition in IBD among patients and providers. METHODS: Surveys were mailed electronically to patients and providers identified through their membership in the Crohn's & Colitis Foundation of America...
October 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27563706/selenoproteins-and-oxidative-stress-induced-inflammatory-tumorigenesis-in-the-gut
#17
Caitlyn W Barrett, Sarah P Short, Christopher S Williams
Selenium is an essential micronutrient that is incorporated into at least 25 selenoproteins encoded by the human genome, many of which serve antioxidant functions. Because patients with inflammatory bowel disease (IBD) demonstrate nutritional deficiencies and are at increased risk for colon cancer due to heightened inflammation and oxidative stress, selenoprotein dysfunction may contribute to disease progression. Over the years, numerous studies have analyzed the effects of selenoprotein loss and shown that they are important mediators of intestinal inflammation and carcinogenesis...
August 25, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27559472/improving-pediatric-inflammatory-bowel-disease-ibd-follow-up
#18
Dana Dykes, Elizabeth Williams, Peter Margolis, Jennifer Ruschman, Julianne Bick, Shehzad Saeed, Lisa Opipari
Standardization of Inflammatory Bowel Disease (IBD) care through participation in the ImproveCareNow (ICN) Network has improved outcomes for pediatric patients with IBD, but under the current care model, our improvements have plateaued. Current ICN model care guidelines recommend health supervision visits every six months. We identified a gap in our practice's ability to ensure either a routine six month follow-up or a rapid follow-up after a disease flare, and a significant number of patients with active disease status during a six month period lacked timely reassessment after interventions or medication changes...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27529220/urinary-metabolic-phenotyping-reveals-differences-in-the-metabolic-status-of-healthy-and-inflammatory-bowel-disease-ibd-children-in-relation-to-growth-and-disease-activity
#19
Francois-Pierre Martin, Jessica Ezri, Ornella Cominetti, Laeticia Da Silva, Martin Kussmann, Jean-Philippe Godin, Andreas Nydegger
BACKGROUND: Growth failure and delayed puberty are well known features of children and adolescents with inflammatory bowel disease (IBD), in addition to the chronic course of the disease. Urinary metabonomics was applied in order to better understand metabolic changes between healthy and IBD children. METHODS: 21 Pediatric patients with IBD (mean age 14.8 years, 8 males) were enrolled from the Pediatric Gastroenterology Outpatient Clinic over two years. Clinical and biological data were collected at baseline, 6, and 12 months...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27462352/nutritional-concerns-in-pediatric-inflammatory-bowel-disease
#20
REVIEW
Yong Joo Kim
The pathophysiology and fundamental etiologic mechanism of inflammatory bowel disease (IBD) is not well understood even though therapeutic regimens and drugs are rapidly evolutionary. IBD has complicated connections with genetic, immunologic, gut microbial, environmental, and nutritional factors. It is not clearly well known to the physicians how to feed, what nutrients are more helpful, and what food to be avoided. This review discusses the issues of growth and important nutritional concerns in the management of IBD in childhood...
June 2016: Korean Journal of Pediatrics
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