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https://www.readbyqxmd.com/read/28737965/comparison-of-three-competitive-immunoassays-for-measurement-of-tsh-receptor-antibodies-in-patients-with-graves-disease
#1
Sara Doroudian, Inge Bülow Pedersen, Cindy Soendersoe Knudsen, Aase Handberg, Stine Linding Andersen
Thyrotropin (TSH) receptor antibodies (TRAb) mediate the hyperthyroidism of Graves' disease (GD). The aim of the study was to compare the diagnostic performance and assay agreement between three immunoassays for the measurement of TRAb in patients with newly diagnosed GD. TRAb was measured with three different assays [H-TRAb (BRAHMS Diagnostica), M22-Man (RSR Limited) and M22-Aut (Roche Diagnostics)] in 387 participants who were recruited from two Danish population-based studies and diagnosed with GD (n = 101), multinodular toxic goitre (n = 88), primary autoimmune hypothyroidism (n = 100) or included as controls (n = 98)...
July 24, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28729772/serial-stimulated-thyroglobulin-measurements-are-more-specific-for-detecting-distant-metastatic-differentiated-thyroid-cancer-before-radioiodine-therapy
#2
Teng Zhao, Jun Liang, Tianjun Li, Wen Gao, Yansong Lin
OBJECTIVE: Preablative stimulated thyroglobulin (ps-Tg) has the potential to be used in identifying distant metastatic differentiated thyroid carcinoma (DM-DTC), but its single level can be affected by remnant thyroid tissue and thyrotropin (TSH). The objective of this retrospective study was to evaluate the value of serial ps-Tg measurements in identifying DM-DTC specifically. METHODS: A total of 317 DTC patients with serial measurements of ps-Tg, TSH and anti-Tg antibody were divided into M1 (n=72) and M0 (n=245) according to the presence of distant metastasis (DM) or not...
June 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28721126/the-thyroid-gland-in-postmenopausal-women-physiology-and-diseases
#3
REVIEW
Małgorzata Gietka-Czernel
The incidence of most thyroid diseases: hypothyroidism, nodular goitre, and cancer is highest among postmenopausal and elderly women. The diagnosis of thyroid dysfunction in this group of patients is difficult because the symptoms can be nonspecific or common with menopausal and ageing complaints. In the interpretation of thyroid function tests the physiological changes in secretion and metabolism of thyrotropin (TSH) and thyroid hormones must be considered, as well as the influence of comorbidities. Unrecognised thyroid dysfunction leads to increased: cardiovascular risk, bone fractures, cognitive impairment, depression, and mortality...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28720519/taltirelin-alleviates-fatigue-like-behavior-in-mouse-models-of-cancer-related-fatigue
#4
John P Dougherty, Brian S Wolff, Mary J Cullen, Leorey N Saligan, Marvin C Gershengorn
Fatigue affects most cancer patients and has numerous potential causes, including cancer itself and cancer treatment. Cancer-related fatigue (CRF) is not relieved by rest, can decrease quality of life, and has no FDA-approved therapy. Thyrotropin-releasing hormone (TRH) has been proposed as a potential novel treatment for CRF, but its efficacy against CRF remains largely untested. Thus, we tested the TRH analog, taltirelin (TAL), in mouse models of CRF. To model fatigue, we used a mouse model of chemotherapy, a mouse model of radiation therapy, and mice bearing colon 26 carcinoma tumors...
July 15, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28705886/thyroid-status-quality-of-life-and-mental-health-in-patients-on-hemodialysis
#5
Connie M Rhee, Yanjun Chen, Amy S You, Steven M Brunelli, Csaba P Kovesdy, Matthew J Budoff, Gregory A Brent, Kamyar Kalantar-Zadeh, Danh V Nguyen
BACKGROUND AND OBJECTIVES: In the general population, there is increasing recognition of the effect of thyroid function on patient-centered outcomes, including health-related quality of life and depression. Although hypothyroidism is highly prevalent in hemodialysis patients, it is unknown whether thyroid status is a risk factor for impaired health-related quality of life or mental health in this population. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We examined the association of thyroid status, defined by serum thyrotropin, with health-related quality of life and depressive symptoms over time in a prospective cohort of 450 patients on hemodialysis from 17 outpatient dialysis facilities from May of 2013 to May of 2015 who underwent protocolized thyrotropin testing, Short-Form 36 surveys, and Beck Depression Inventory-II questionnaires every 6 months...
July 13, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28701428/a-mercury-toxicity-case-complicated-by-hyponatremia-and-abnormal-endocrinological-test-results
#6
Matthew Carter, Abdul Abdi, Fareeha Naz, Farouq Thabet, Arpita Vyas
Mercury (Hg) poisoning is considered a rare disease by the National Institutes of Health and the diagnosis can present great challenges to clinicians. Children who are exposed to Hg can present with a wide variety of symptoms, including acrodynia, tremor, excessive salivation, and psychiatric symptoms, including insomnia. However, endocrinologic manifestations from Hg exposure are less well known. This is a case report of a 12-year-old boy who presented with body rash, irritability, insomnia, and profuse sweating after returning from a summer camp...
July 13, 2017: Pediatrics
https://www.readbyqxmd.com/read/28693124/pediatric-toxic-polycystic-thyroid
#7
Janeil M Belle, Nektarios Vasilottos, Todd D Nebesio, Benjamin C James
BACKGROUND: Polycystic thyroid disease (PCTD) is a rare condition and has been described in adults in the setting of subclinical and clinical hypothyroidism. We present the first known case of a pediatric patient with diffuse macrocystic degeneration of the thyroid. CLINICAL PRESENTATION: A 6-year-old previously healthy patient was evaluated after presenting with a 16-month history of an enlarging polycystic thyroid and hyperthyroidism. Markers of autoimmune thyroid disease including thyroid stimulating immunoglobulin (TSI), thyroid stimulating hormone (TSH) receptor antibody, thyroid peroxidase antibody and thyroglobulin antibody were negative...
June 16, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28688760/-once-weekly-l-thyroxine-treatment-in-non-compliance-a-case-report
#8
C Oliver, M Grino, P Moatti Vacher-Coponat, I Morange, F Retornaz
INTRODUCTION: The non-adherence to substitutive treatment by L-thyroxine is the main cause of the discordance between high thyrotropin values and high doses of the drug. OBSERVATION: In a 36-year-old patient with post-surgery hypothyroidism, thyrotropin values ranged between 100 and 400 mUI/L, although daily replacement therapy included 300 μg of L-thyroxine and 75 μg of L-triiodothyronine. The oral loading test with L-thyroxine was normal and thyrotropin serum level returned to normal values under weekly oral administration of 1000 μg L-thyroxine...
July 5, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28688088/early-stimulated-thyroglobulin-for-response-prediction-after-recombinant-human-thyrotropin-aided-radioiodine-therapy
#9
Hee Jeong Park, Jung-Joon Min, Hee-Seung Bom, Jahae Kim, Ho-Chun Song, Seong Young Kwon
OBJECTIVE: Measurement of recombinant human thyrotropin (rhTSH)-stimulated thyroglobulin (Tg) is generally recommended 72 h after the second rhTSH injection. However, due to the acute effect of I-131 on thyrocytes, Tg measured after radioiodine therapy (RIT) would not accurately reflect the thyroid tissue burden. We aimed to determine predictive values of serum Tg level measured just before rhTSH-aided RIT and to compare the results obtained just after RIT in patients with differentiated thyroid carcinoma (DTC)...
July 7, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28686898/prenatal-transfer-of-decabromodiphenyl-ether-bde-209-results-in-disruption-of-the-thyroid-system-and-developmental-toxicity-in-zebrafish-offspring
#10
Zhihua Han, Yufei Li, Shenghu Zhang, Ninghui Song, Huaizhou Xu, Yao Dang, Chunsheng Liu, John P Giesy, Hongxia Yu
Decabromodiphenyl ether (BDE-209) was one of most widely-used polybrominated diphenyl ether (PBDE) flame retardants and is frequently detected in both abiotic and biotic samples from environment. However, knowledge of its transgenerational risks is limited. Here, 4-month-old zebrafish were exposed to various concentrations of BDE-209 (0, 3, 30 or 300μg/L) for 28days and spawned in clean water without BDE-209. Concentrations of triiodothyronine (T3) and thyroxine (T4) as well as expressions of genes involved in the hypothalamic-pituitary-thyroid (HPT) axis were measured in offspring after exposure of adult zebrafish to BDE-209...
June 23, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28685517/free-thyroxine-anti-thyroid-stimulating-hormone-receptor-antibody-titers-and-absence-of-goiter-were-associated-with-responsiveness-to-methimazole-in-patients-with-new-onset-graves-disease
#11
Hoon Sung Choi, Won Sang Yoo
BACKGROUND: Anti-thyroid drug therapy is considered a treatment of choice for Graves' disease; however, treatment response varies among individuals. Although several studies have reported risk factors for relapse after initial treatment, few have assessed responsiveness during the early treatment period. Our study aimed to identify the clinical characteristics for responsiveness to methimazole. METHODS: We included 99 patients diagnosed with Graves' disease for the first time...
June 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28684460/abdominal-surgery-induced-gastric-ileus-and-activation-of-m1-like-macrophages-in-the-gastric-myenteric-plexus-prevention-by-central-vagal-activation-in-rats
#12
Pu-Qing Yuan, Yvette Taché
Inflammation plays a role in abdominal surgery (AS)-induced intestinal ileus that is alleviated by electrical vagal stimulation. The stable thyrotropin-releasing hormone agonist, RX77368 injected intracisternally (ic) activates dorsal motor nucleus neurons and gastric vagal efferent discharges. We investigated the gastric inflammation induced by AS and the modulation by ic RX-77368 in rats. RX77368 (50 ng/rat) or saline was injected ic followed, 1 h later, by laparotomy and small intestinal/cecal manipulation...
July 6, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28684452/lower-tsh-and-higher-free-thyroxine-predict-incidence-of-prostate-but-not-breast-colorectal-or-lung-cancer
#13
Yi Xian Chan, Matthew Knuiman, Mark L Divitini, Suzanne J Brown, John P Walsh, Bu Beng Yeap
CONTEXT: Thyroid hormones modulate proliferative, metabolic and angiogenic pathways, however few studies have examined associations of thyroid hormones with cancer risk. OBJECTIVES: To explore associations of thyrotropin (TSH), free thyroxine (FT4) and anti-thyroperoxidase antibodies (TPOAb) with the incidence of all (non-skin) cancers and specific common cancers. DESIGN AND SETTING: A prospective cohort study of a community-dwelling population aged 25-84 years in Western Australia...
July 6, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28680357/direct-estimation-of-reference-intervals-for-thyroid-parameters-in-the-republic-of-srpska
#14
Bosa Mirjanic-Azaric, Sanja Avram, Tanja Stojakovic-Jelisavac, Darja Stojanovic, Mira Petkovic, Natasa Bogavac-Stanojevic, Svetlana Ignjatovic, Marina Stojanov
BACKGROUND: The aim of this study was to determine the reference values for thyrotropin (TSH), thyroid hormones (total and free thyroxine, T4 and fT4; total and free triiodothyronine, T3 and fT3), thyroglobulin (Tg) and thyroid antibodies (thyroid peroxidase, TPOAb and thyroglobulin antibody, TgAb) in the population of the Republic of Srpska. METHODS: A total of 250 euthyroid subjects were enrolled in this study. A direct method for choosing reference subjects was used to establish reference intervals...
April 2017: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28678169/the-relationship-of-tpoab-and-tgab-with-risk-of-thyroid-nodules-a-large-epidemiological-study
#15
Weimin Xu, Liangliang Huo, Zexin Chen, Yangmei Huang, Xingyi Jin, Jing Deng, Sujuan Zhu, Yunxian Yu
Objective: The association between thyroid hormones, thyroid autoantibodies, and thyroid nodules are still not clear. The cross-sectional study, conducted in Hangzhou, China in 2010, aimed to identify the relationship of thyroid hormones and autoantibodies with thyroid nodules. Methods: Information regarding social demography was collected by a questionnaire. Thyroid hormones (triiodothyronine, thyroxin, free triiodothyronine, free thyroxin, thyrotropin), thyroid autoantibodies (thyroid peroxidase antibody, antithyroglobulin antibody), and thyroid nodules (diagnosed by ultrasonography) was measured in 1271 adults...
July 5, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28677070/i-131-biokinetics-of-remnant-normal-thyroid-tissue-and-residual-thyroid-cancer-in-patients-with-differentiated-thyroid-cancer-comparison-between-recombinant-human-tsh-administration-and-thyroid-hormone-withdrawal
#16
Chae Moon Hong, Choon-Young Kim, Seung Hyun Son, Ji-Hoon Jung, Chang-Hee Lee, Ju Hye Jeong, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
OBJECTIVE: The aim of this study was to assess I-131 biokinetics in thyroid cancer and remnant tissue in patients with differentiated thyroid cancer using whole-body scan (WBS) and SPECT images acquired after I-131 therapy. The influence of thyroid stimulating hormone (TSH) stimulation method on the kinetics was also evaluated. METHODS: A total of 57 patients who received I-131 therapy (2.96-7.4 GBq) were retrospectively included. TSH stimulation was achieved by recombinant human thyrotropin (rhTSH) or by thyroid hormone withdrawal (THW)...
July 4, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28672775/pediatric-toxic-polycystic-thyroid
#17
Janeil M Belle, Nektarios Vasilottos, Todd D Nebesio, Benjamin C James
BACKGROUND: Polycystic thyroid disease (PCTD) is a rare condition and has been described in adults in the setting of subclinical and clinical hypothyroidism. We present the first known case of a pediatric patient with diffuse macrocystic degeneration of the thyroid. CLINICAL PRESENTATION: A 6-year-old previously healthy patient was evaluated after presenting with a 16-month history of an enlarging polycystic thyroid and hyperthyroidism. Markers of autoimmune thyroid disease including thyroid stimulating immunoglobulin (TSI), thyroid stimulating hormone (TSH) receptor antibody, thyroid peroxidase antibody and thyroglobulin antibody were negative...
July 26, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28666345/thyroid-hemiagenesis-incidence-clinical-significance-and-genetic-background
#18
Ewelina Szczepanek-Parulska, Ariadna Zybek-Kocik, Leonard Wartofsky, Marek Ruchala
Context: Thyroid hemiagenesis (THA) constitutes a rare, congenital disorder that is characterized by an absence of one thyroid lobe. Because the pathogenesis and clinical significance of this malformation remain undefined, specific clinical recommendations are lacking, especially for asymptomatic cases. Evidence Acquisition: The PubMed Database was searched (years 1970-2017) and the following terms were used to retrieve the results: "thyroid hemiagenesis", "thyroid hemiaplasia", "one thyroid lobe agenesis" and "one thyroid lobe aplasia"...
June 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28658938/low-thyroid-hormone-levels-disrupt-thyrotrope-development
#19
Ksenia Tonyushkina, Stefanie Krug, Theresa Ortiz-Toro, Tibor Mascari, Rolf Karlstrom
Low thyroid hormone (TH) conditions caused by a variety of pre- and perinatal problems have been shown to alter postnatal regulatory thyrotropin (TSH) responsiveness to TH in humans and rodents. The mechanisms underlying this pituitary TH-resistance remain unknown. Here we use the evolutionarily conserved zebrafish model to examine the effects of low TH on thyrotrope development and function. Zebrafish were exposed to the goitrogen 6-propyl-2-thiouracil (PTU) in order to block TH synthesis and this led to an approximately 50% increase in thyrotrope numbers and a 8-10 fold increase in tshb mRNA abundance in 2 week old larvae and 1 month old juveniles...
June 27, 2017: Endocrinology
https://www.readbyqxmd.com/read/28648512/the-multiple-genetic-causes-of-central-hypothyroidism
#20
REVIEW
Luca Persani, Marco Bonomi
An insufficient stimulation by thyrotropin (TSH) of an otherwise normal thyroid gland represents the cause of Central Hypothyrodism (CeH). CeH is about 1000-folds rarer than Primary Hypothyroidism and often represents a real challenge for the clinicians, mainly because they cannot rely on adequately sensitive parameters for diagnosis or management, as it occurs with circulating TSH in PH. Therefore, CeH diagnosis can be frequently missed or delayed in patients with a previously unknown pituitary involvement...
March 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
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