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https://www.readbyqxmd.com/read/28212475/-frequency-of-increased-thyrotropin-in-women-with-hyperprolactinemia
#1
Sebastián Carranza-Lira, María Luisa Daza-Carrasco, Rosario Chán-Verdugo
BACKGROUND: Hypothyroidism has been associated to hyperprolactinemia. The aim was to establish the frequency of high thyrotropin (TSH) levels in women with hyperprolactinemia. METHODS: Retrospective, observational, open, and non-controlled study, which included all the non-pregnant women whose prolactin (PRL) and TSH levels were measured between January 1 and December 31, 2014. RESULTS: 437 women were studied. The most frequent diagnoses that motivated PRL measurement were: infertility (31...
2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28204898/surgical-treatment-and-outcome-of-tsh-producing-pituitary-adenomas
#2
Roman Rotermund, Nina Riedel, Till Burkhardt, Jakob Matschke, Nils-Ole Schmidt, Jens Aberle, Jörg Flitsch
BACKGROUND: Thyrotropin-producing adenomas (TSHomas) account for approximately 1-2% of all pituitary tumors. Recently, there has been debate on primary treatment as some studies suggest a high rate of hypopituitarism after transsphenoidal surgery and therefore suggest primary use of somatostatin analogs (SSA) instead. We would like to challenge this assumption by presenting our single-center experience with transsphenoidal surgery for TSHoma. METHODS: Fifteen patients treated consecutively between May 2010 and December 2016 were analyzed for long-term postoperative remission and pituitary function...
February 15, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28201922/diagnosis-of-osteoporosis-in-rural-arctic-greenland-a-clinical-case-using-plain-chest-radiography-for-secondary-prevention-and-consideration-of-tools-for-primary-prevention-in-remote-areas
#3
Inuuteq Fleischer, Louise K Schæbel, Nadja Albertsen, Vibeke N Sørensen, Stig Andersen
CONTEXT: Osteoporosis is a frequent disease in many populations. The hallmark is fragility fractures, which are harbingers of future fractures, disability, mortality and cost on society. The occurrence increases with age, low vitamin D level and smoking. Smoking rates are high, vitamin D is low and life expectancy is rising steeply in Greenland, as is the need for focus on osteoporosis. We report a case that uses a simple and readily available tool to diagnose osteoporosis at the hospital in Sisimiut, a town of 5000 inhabitants on the west coast of Greenland...
January 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28195550/novel-germline-mutation-leu512met-in-the-thyrotropin-receptor-gene-tshr-leading-to-sporadic-non-autoimmune-hyperthyroidism
#4
Stephanie A Roberts, Jennifer E Moon, Andrew Dauber, Jessica R Smith
BACKGROUND: Primary nonautoimmune hyperthyroidism is a rare cause of neonatal hyperthyroidism. This results from an activating mutation in the thyrotropin-receptor (TSHR). It can be inherited in an autosomal dominant manner or occur sporadically as a de novo mutation. Affected individuals display a wide phenotype from severe neonatal to mild subclinical hyperthyroidism. We describe a 6-month-old boy with a de novo mutation in the TSHR gene who presented with accelerated growth, enlarging head circumference, tremor and thyrotoxicosis...
February 14, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28181228/thyrotropin-receptor-gene-expression-in-the-association-between-chronic-spontaneous-urticaria-and-hashimoto-s-thyroiditis
#5
Maria R C Silvares, Maria R P Fortes, Renata de A M L Nascimento, Carlos R Padovani, Hélio A Miot, Célia R Nogueira, Gláucia M F da S Mazeto
BACKGROUND: Chronic spontaneous urticaria (CSU) may be associated with autoimmune thyroid diseases, and the Autologous Serum Skin Test (ASST) is an autoreactivity marker. The thyrotropin (TSH) and TSH receptor (TSHR) could play a role in the pathogenesis of CSU. The aim of this study was to evaluate ASST positivity and TSHR gene expression in healthy skin and ASST wheals in euthyroid women with CSU, with (14 patients) and without (15 patients) Hashimoto's thyroiditis (HT). METHODS: ASST was performed and TSHR gene expression studied in wheals induced by ASST and in healthy skin...
February 8, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28173961/a-screen-for-modulators-reveals-that-orexin-a-rapidly-stimulates-thyrotropin-releasing-hormone-expression-and-release-in-hypothalamic-cell-culture
#6
Antonieta Cote-Vélez, Anabel Martínez Báez, Leticia Lezama, Rosa María Uribe, Patricia Joseph-Bravo, Jean-Louis Charli
In the paraventricular nucleus of the mammalian hypothalamus, hypophysiotropic thyrotropin releasing hormone (TRH) neurons integrate metabolic information and control the activity of the thyroid axis. Additional populations of TRH neurons reside in various hypothalamic areas, with poorly defined connections and functions, albeit there is evidence that some may be related to energy balance. To establish extracellular modulators of TRH hypothalamic neurons activity, we performed a screen of neurotransmitters effects in hypothalamic cultures...
February 2, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28166158/interrupted-131i-procedures-for-patients-with-differentiated-thyroid-cancer-comparing-thyroxine-withdrawal-with-recombinant-thyrotropin-preparation-techniques
#7
Shawn Karls, Gad Abikhzer, Michael Tamilia, Stephan Probst
OBJECTIVE: In patients with differentiated thyroid carcinoma scheduled to receive doses of I for diagnostic or therapeutic purposes, we compared patients prepared with thyroid hormone withdrawal (THW) versus recombinant human thyroid stimulating hormone (rh-TSH) to evaluate the incidence of cancelled procedures because of inadequate thyroid stimulation. METHODS: Thyroid cancer patients after thyroidectomy who were scheduled for diagnostic or therapeutic I procedures between January 2012 and June 2015 were retrospectively reviewed...
February 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28165356/n-glycoprofiling-analysis-for-carbohydrate-composition-and-site-occupancy-determination-in-a-poly-glycosylated-protein-human-thyrotropin-of-different-origins
#8
Maria Teresa C P Ribela, Renata Damiani, Felipe D Silva, Eliana R Lima, João E Oliveira, Cibele N Peroni, Peter A Torjesen, Carlos R Soares, Paolo Bartolini
Human thyrotropin (hTSH) is a glycoprotein with three potential glycosylation sites: two in the α-subunit and one in the β-subunit. These sites are not always occupied and occupancy is frequently neglected in glycoprotein characterization, even though it is related to folding, trafficking, initiation of inflammation and host defense, as well as congenital disorders of glycosylation (CDG). For the first time N-glycoprofiling analysis was applied to the site-occupancy determination of two native pituitary hTSH, in comparison with three recombinant preparations of hTSH, a widely used biopharmaceutical...
February 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28153798/thyroid-hormone-biosynthesis-and-release
#9
Denise P Carvalho, Corinne Dupuy
Thyroid hormones (TH) 3,5,3',5'- tetraiodothyronine or thyroxine (T4) and 3,5,3'- triiodothyronine (T3) contain iodine atoms as part of their structure, and their synthesis occur in the unique structures called thyroid follicles. Iodide reaches thyroid cells through the bloodstream that supplies the basolateral plasma membrane of thyrocytes, where it is avidly taken up through the sodium/iodide symporter (NIS). Thyrocytes are also specialized in the secretion of the high molecular weight protein thyroglobulin (TG) in the follicular lumen...
January 31, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28151897/preparation-for-radioactive-iodine-therapy-is-not-a-risk-factor-for-the-development-of-hyponatremia-in-thyroid-cancer-patients
#10
Jahae Kim, Sang-Geon Cho, Sae-Ryung Kang, Seong Young Kwon, Dong-Hyeok Cho, Jin-Seong Cho, Ho-Chun Song
The aim of this study was to evaluate whether the preparation for radioactive iodine (RAI) therapy by thyroid hormone withdrawal (THW) or a low-iodine diet (LID) can be risk factors for the development of hyponatremia in patients with differentiated thyroid cancer after thyroidectomy.We retrospectively reviewed the medical records and laboratory findings of 326 patients who underwent preparation for RAI therapy after thyroidectomy from 2012 to 2014. Demographic and clinical variables including the method of thyrotropin stimulation and duration of LID were assessed...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28148249/what-is-the-association-of-hypothyroidism-with-risks-of-cardiovascular-events-and-mortality-a-meta-analysis-of-55-cohort-studies-involving-1-898-314-participants
#11
Yu Ning, Yun J Cheng, Li J Liu, Jaskanwal D S Sara, Zhi Y Cao, Wei P Zheng, Tian S Zhang, Hui J Han, Zhen Y Yang, Yi Zhang, Fei L Wang, Rui Y Pan, Jie L Huang, Ling L Wu, Ming Zhang, Yong X Wei
BACKGROUND: Whether hypothyroidism is an independent risk factor for cardiovascular events is still disputed. We aimed to assess the association between hypothyroidism and risks of cardiovascular events and mortality. METHODS: We searched PubMed and Embase from inception to 29 February 2016. Cohort studies were included with no restriction of hypothyroid states. Priori main outcomes were ischemic heart disease (IHD), cardiac mortality, cardiovascular mortality, and all-cause mortality...
February 2, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28134999/pathogenesis-of-hyperthyroidism
#12
Ishita Singh, Jerome M Hershman
Hyperthyroidism is a form of thyrotoxicosis in which there is excess thyroid hormone synthesis and secretion. Multiple etiologies can lead to a common clinical state of "thyrotoxicosis," which is a consequence of the high thyroid hormone levels and their action on different tissues of the body. The most common cause of thyrotoxicosis is Graves' disease, an autoimmune disorder in which stimulating thyrotropin receptor antibodies bind to thyroid stimulating hormone (TSH) receptors on thyroid cells and cause overproduction of thyroid hormones...
December 6, 2016: Comprehensive Physiology
https://www.readbyqxmd.com/read/28127991/tshr-as-a-therapeutic-target-in-graves-disease
#13
Terry Smith
Introduction Graves' disease (GD) and thyroid-associated ophthalmopathy (TAO) are thought to result from actions of pathogenic antibodies mediated through the thyrotropin receptor (TSHR). This leads to the unregulated consequences of the antibody-mediated receptor activity in the thyroid and connective tissues of the orbit. Recent studies reveal antibodies that appear to be directed against the insulin-like growth factor-I receptor (IGF-IR). Areas covered In this brief article, I attempt to review the fundamental characteristics of the TSHR, its role in GD and TAO, and its relationship to IGF-IR...
January 27, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28123504/identification-and-functional-characterization-of-a-novel-thyrotropin-receptor-mutation-v87l-in-a-chinese-woman-with-subclinical-hypothyroidism
#14
Hong-Mei Zhang, Ya-Qin Zhou, Yan Dong, Qing Su
The thyrotropin receptor (TSHR) gene has been defined as a highly mutable gene. Mutations in the TSHR gene result in either gain or loss of the receptor function. Subclinical hypothyroidism (SH) is a clinical condition defined as an elevated serum TSH level associated with normal free thyroxine and free triiodothyronine. Chronic autoimmune thyroiditis is the most frequent cause of subclinical hypothyroidism in adults. In rare cases, a loss-of-function mutation of TSHR is the cause of SH. In the present study, a novel TSHR mutation (V87L; confirmed to be a loss-of-function mutation) was identified in a 59-year-old Chinese woman, as the potential cause of the patient's subclinical hypothyroidism...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28101489/correction-of-hypothyroidism-leads-to-change-in-lean-body-mass-without-altering-insulin-resistance
#15
Sangeetha Sirigiri, Suresh Vaikkakara, Alok Sachan, P V L N Srinivasarao, Sunil Epuri, Sailaja Anantarapu, Arun Mukka, Srinivasa Rao Chokkapu, Ashok Venkatanarasu, Ravi Poojari
BACKGROUND: Hypothyroidism is associated with insulin resistance, dyslipidemia, and abnormal body composition. This study assessed changes in body composition and insulin resistance after thyroxine (T4) replacement in overt hypothyroidism. METHODS: In this prospective longitudinal study carried out in a tertiary care center, adult nondiabetic patients with overt hypothyroidism were rendered euthyroid on T4. Anthropometry including skinfold thickness (SFT) at the triceps and subscapularis was recorded...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28100628/external-validation-of-the-great-score-to-predict-relapse-risk-in-graves-disease-results-from-a-multicenter-retrospective-study-with-741-patients
#16
Tristan Struja, Marina Kaeslin, Fabienne Boesiger, Rebecca Jutzi, Noemi Imahorn, Alexander Kutz, Luca Bernasconi, Esther Mundwiler, Beat Mueller, Mirjam Christ-Crain, Fabian Meienberg, Fahim Ebrahimi, Christoph Henzen, Stefan Fischli, Marius Kraenzlin, Christian Meier, Philipp Schuetz
CONTEXT: First line treatment in Graves' disease is often done with antithyroid agents (ATD) but relapse rates remain high making definite treatment necessary. Predictors for relapse risk help guiding initial treatment decisions. OBJECTIVE: We aimed to externally validate the prognostic accuracy of the recently proposed Graves' Recurrent Events After Therapy [GREAT] score to predict relapse risk in Graves` disease. DESIGN, SETTING, AND PARTICIPANTS: We retrospectively analyzed data (2004-2014) of patients with a first episode of Graves' hyperthyroidism from four Swiss endocrine outpatient clinics...
January 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28099999/high-level-intrathymic-thyrotrophin-receptor-expression-in-thyroiditis-prone-mice-protects-against-the-spontaneous-generation-of-pathogenic-thyrotrophin-receptor-autoantibodies
#17
S M McLachlan, H A Aliesky, B Banuelos, S Lesage, R Collin, B Rapoport
The thyrotrophin receptor (TSHR) A-subunit is the autoantigen targeted by pathogenic autoantibodies that cause Graves' hyperthyroidism, a common autoimmune disease in humans. Previously, we reported that pathogenic TSHR antibodies develop spontaneously in thyroiditis-susceptible non-obese diabetic (NOD).H2(h4) mice bearing a human TSHR A-subunit transgene, which is expressed at low levels in both the thyroid and thymus (Lo-expressor transgene). The present study tested recent evidence that high intrathymic TSHR expression protects against the development of pathogenic TSHR antibodies in humans...
January 18, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28073937/activity-of-tachykinin1-expressing-pet1-raphe-neurons-modulates-the-drive-to-breathe
#18
Morgan L Hennessy, Andrea Corcoran, Rachael D Brust, Eugene E Nattie, Susan Dymecki
: Homeostatic control of breathing, heart rate, and body temperature relies on circuits within the brainstem modulated by the neurotransmitter serotonin (5-HT). Mounting evidence points to specialized neuronal subtypes within the 5-HT system, which have borne out in functional studies, including the modulation of distinct facets of homeostatic control. These functional differences, read out at the organismal level, are likely subserved by differences among 5-HT neuron subtypes at the cellular and molecular levels, including differences in the capacity to co-express other neurotransmitters such as glutamate, GABA, thyrotropin releasing hormone, and substance P encoded by the Tachykinin-1 (Tac1) gene...
January 10, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28073129/alternative-treatment-strategies-in-women-poorly-tolerating-moderate-doses-of-bromocriptine
#19
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
Background: Metformin as well as dopaminergic agents exert a beneficial effect on glucose and lipid metabolism, often impaired in patients with hyperprolactinemia. Objective: The aim of this study was to compare metabolic- and prolactin-lowering effects of low-dose bromocriptine/metformin combination therapy and cabergoline in patients with elevated prolactin levels. Methods: The study included 27 women with hyperprolactinemia and impaired glucose tolerance who were treated with moderate doses of bromocriptine but experienced adverse effects of this treatment...
January 10, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28073128/the-effect-of-vitamin-d-on-thyroid-autoimmunity-in-levothyroxine-treated-women-with-hashimoto-s-thyroiditis-and-normal-vitamin-d-status
#20
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
Background: Low vitamin D status is associated with autoimmune thyroid disease. Oral vitamin D supplementation was found to reduce titers of thyroid antibodies in levothyroxine-treated women with postpartum thyroiditis and low vitamin D status. Methods: The study included 34 women with Hashimoto's thyroiditis and normal vitamin D status (serum 25-hydroxyvitamin D levels above 30 ng/mL) who had been treated for at least 6 months with levothyroxine. On the basis of patient preference, women were divided into 2 groups, receiving (n=18) or not receiving (n=16) oral vitamin D preparations (2000 IU daily)...
January 10, 2017: Experimental and Clinical Endocrinology & Diabetes
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