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https://www.readbyqxmd.com/read/29163009/regulatory-pathways-of-monoamine-oxidase-a-during-social-stress
#1
REVIEW
Yuki Higuchi, Tomoko Soga, Ishwar S Parhar
Social stress has a high impact on many biological systems in the brain, including serotonergic (5-HT) system-a major drug target in the current treatment for depression. Hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis and monoamine oxidase A (MAO-A) are well-known stress responses, which are involved in the central 5-HT system. Although, many MAO-A inhibitors have been developed and used in the therapeutics of depression, effective management of depression by modulating the activity of MAO-A has not been achieved...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29138643/interactions-of-desmethoxyyangonin-a-secondary-metabolite-from-renealmia-alpinia-with-human-monoamine-oxidase-a-and-oxidase-b
#2
Narayan D Chaurasiya, Francisco León, Yuanqing Ding, Isabel Gómez-Betancur, Dora Benjumea, Larry A Walker, Stephen J Cutler, Babu L Tekwani
Renealmia alpinia (Zingiberaceae), a medicinal plant of tropical rainforests, is used to treat snakebites and other injuries and also as a febrifuge, analgesic, antiemetic, antiulcer, and anticonvulsant. The dichloromethane extract of R. alpinia leaves showed potent inhibition of human monoamine oxidases- (MAOs-) A and B. Phytochemical studies yielded six known compounds, including pinostrobin 1, 4'-methyl ether sakuranetin 2, sakuranetin 3, pinostrobin chalcone 4, yashabushidiol A 5, and desmethoxyyangonin 6...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29126727/design-synthesis-and-biochemical-evaluation-of-novel-multi-target-inhibitors-as-potential-anti-parkinson-agents
#3
Simone Carradori, Francesco Ortuso, Anél Petzer, Donatella Bagetta, Celeste De Monte, Daniela Secci, Daniela De Vita, Paolo Guglielmi, Gokhan Zengin, Abdurrahman Aktumsek, Stefano Alcaro, Jacobus P Petzer
New 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives are proposed as dual-target-directed monoamine oxidase B (MAO-B) and acetylcholinesterase (AChE) inhibitors, as well as antioxidant agents, for the treatment of neurodegenerative disorders such as Parkinson's disease. Rational molecular design, target recognition and predicted pharmacokinetic properties have been evaluated by means of molecular modelling. Based on these properties, compounds were synthesized and evaluated in vitro as MAO-B and AChE inhibitors, and compared to the activities at their corresponding isozymes, monoamine oxidase A (MAO-A) and butyrylcholinesterase (BuChE), respectively...
October 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29126721/synthesis-monoamine-oxidase-inhibition-activity-and-molecular-docking-studies-of-novel-4-hydroxy-n-benzylidene-or-1-phenylethylidene-2-h-methyl-benzyl-1-2-benzothiazine-3-carbohydrazide-1-1-dioxides
#4
Furqan Ahmad Saddique, Sumera Zaib, Saquib Jalil, Sana Aslam, Matloob Ahmad, Sadia Sultan, Humera Naz, Mazhar Iqbal, Jamshed Iqbal
Three series of 4-hydroxy-N(')-[benzylidene/1-phenylethylidene]-2-H/methyl/benzyl-1,2-benzothiazine-3-carbohydrazide 1,1-dioxides (9-11)a-l were synthesized and unraveled to be highly potent dual inhibitors of monoamine oxidases (MAO-A and MAO-B). All the examined compounds demonstrated IC50 values in lower micro-molar range for both MAO-A as well as MAO-B. The most active MAO-A inhibitor was 4-hydroxy-N'-(1-phenylethylidene)-2H-benzo[e][1,2]thiazine-3-carbohydrazide 1,1-dioxide (9i) with an IC50 value of 0...
October 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29093288/synthesis-of-amide-and-ester-derivatives-of-cinnamic-acid-and-its-analogs-evaluation-of-their-free-radical-scavenging-and-monoamine-oxidase-and-cholinesterase-inhibitory-activities
#5
Koichi Takao, Kazuhiro Toda, Takayuki Saito, Yoshiaki Sugita
A series of cinnamic acid derivatives, amides (1-12) and esters (13-22), were synthesized, and structure-activity relationships for antioxidant activity, and monoamine oxidases (MAO) A and B, acetylcholinesterase, and butyrylcholinesterase (BChE) inhibitory activities were analyzed. Among the synthesized compounds, compounds 1-10, 12-18, and rosmarinic acid (23), which contained catechol, o-methoxyphenol or 5-hydroxyindole moieties, showed potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29073746/monoamine-oxidase-a-genetic-variants-and-childhood-abuse-predict-impulsiveness-in-borderline-personality-disorder
#6
Nathan J Kolla, Jeffrey Meyer, Marcos Sanches, James Charbonneau
Objective: Impulsivity is a core feature of borderline personality disorder (BPD) and antisocial personality disorder (ASPD) that likely arises from combined genetic and environmental influences. The interaction of the low activity variant of the monoamine oxidase-A (MAOA-L) gene and early childhood adversity has been shown to predict aggression in clinical and non-clinical populations. Although impulsivity is a risk factor for aggression in BPD and ASPD, little research has investigated potential gene-environment (G×E) influences impacting its expression in these conditions...
November 30, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29065322/sulfonyl-hydrazones-derived-from-3-formylchromone-as-non-selective-inhibitors-of-mao-a-and-mao-b-synthesis-molecular-modelling-and-in-silico-adme-evaluation
#7
Syed Mobasher Ali Abid, Hafiza Amna Younus, Mariya Al-Rashida, Zunaira Arshad, Tooba Maryum, Mazhar Amjad Gilani, Abdulrahman I Alharthi, Jamshed Iqbal
A series of sulfonyl hydrazones derived from 3-formylchromone was synthesized and discovered to be effective, non-selective inhibitors of monoamine oxidases (MAO-A and MAO-B). The compounds are easily (synthetically) accessible in high yields, by simple condensation of 4-methylbenzenesulfonohydrazide with different (un)substituted 3-formylchromones. All compounds had IC50 values in lower micro-molar range (IC50 = 0.33-7.14 μM for MAO-A, and 1.12-3.56 μM for MAO-B). The most active MAO-B inhibitor was N'-[(E)-(6-fluoro-4-oxo-4H-chromen-3-yl)methylidene]-4-methylbenzenesulfonohydrazide (3e) with IC50 value of 1...
October 4, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29031059/tying-up-tranylcypromine-novel-selective-histone-lysine-specific-demethylase-1-lsd1-inhibitors
#8
Yue-Yang Ji, Sen-Dong Lin, Yu-Jie Wang, Ming-Bo Su, Wei Zhang, Hendra Gunosewoyo, Fan Yang, Jia Li, Jie Tang, Yu-Bo Zhou, Li-Fang Yu
Aberrant expression of lysine specific histone demethylase 1 (LSD1) has been increasingly associated with numerous cancer cells and several proof-of-concept studies are strongly suggestive of its potential as a druggable target. Tranylcypromine (TCP) is an antidepressant originally known to target the monoamine oxidases A and B (MAO-A and MAO-B), which are structurally related to LSD1. A number of TCP derivatives have been identified as potent LSD1 inhibitors, with a handful of them currently being tested in clinical trials...
December 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29029974/altered-cardiac-gene-expression-of-noradrenaline-enzymes-transporter-and-%C3%AE-adrenoceptors-in-rat-model-of-rheumatoid-arthritis
#9
Sladjana Dronjak, Bojana Stefanovic, Predrag Jovanovic, Natasa Spasojevic, Milica Jankovic, Ivica Jeremic, Markus Hoffmann
Baseline sympathetic activity was found to be elevated in rheumatoid arthritis (RA) patients and it is related to increased cardiovascular risk in these patients. Although many studies have highlighted the association between RA and increased cardiac sympathetic activity, the underlying mechanistic links remain unclear. The aim of the present study was to understand how diseases-triggered changes in gene expression may result in maladaptive physiological changes. Our results suggest that the equilibrium between noradrenaline synthesis, release and reuptake was disrupted in the ventricles of arthritic rats...
October 6, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29027345/a-strategy-for-specific-fluorescence-imaging-of-monoamine-oxidase%C3%A2-a-in-living-cells
#10
Xiaofeng Wu, Wen Shi, Xiaohua Li, Huimin Ma
Monoamine oxidase (MAO) has two isoforms, MAO-A and MAO-B, which show different functions, and thus selective fluorescence imaging is important for biological studies. Currently, however, specific detection of MAO-A remains a great challenge. Herein, we report a new strategy for specific imaging of MAO-A through the design of fluorogenic probes combining the characteristic structure of an inhibitor of the target enzyme along with propylamine as a recognition moiety. The high specificity of our representative probe is demonstrated by imaging MAO-A in different live cells such as SH-SY5Y (high levels of MAO-A) and HepG2 (high levels of MAO-B), and further validated by western blot analyses...
October 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28970152/in-vitro-multimodal-effect-of-trichilia-catigua-a-juss-meliaceae-bark-aqueous-extract-in-cns-targets
#11
João Bernardo, Federico Ferreres, Ángel Gil-Izquierdo, Romeu António Videira, Patrícia Valentão, Francisco Veiga, Paula B Andrade
ETHNOPHARMACOLOGICAL RELEVANCE: The bark of Trichilia catigua A. Juss. (Meliaceae), popularly known as "big catuaba", is traditionally used in Brazilian folk medicine for its neuroactive potential as memory stimulant, and antinociceptive and antidepressant effects. AIM OF THE STUDY: To study the aqueous extract of T. catigua bark as dual inhibitor of monoamine oxidase A (MAO-A) and acetylcholinesterase (AChE). To explore its antioxidant potential through interaction with xanthine/xanthine oxidase (X/XO) pathway, and to attempt a relationship between its phenolic profile and effects displayed...
September 29, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28948423/repetitive-transcranial-magnetic-stimulation-inhibits-sirt1-mao-a-signaling-in-the-prefrontal-cortex-in-a-rat-model-of-depression-and-cortex-derived-astrocytes
#12
Zheng-Wu Peng, Fen Xue, Cui-Hong Zhou, Rui-Guo Zhang, Ying Wang, Ling Liu, Han-Fei Sang, Hua-Ning Wang, Qing-Rong Tan
Repetitive transcranial magnetic stimulation (rTMS) is a useful monotherapy for depression or adjunctive therapy for resistant depression. However, the anti-depressive effects of different parameters and the underlying mechanisms remain unclear. Here, we aimed to assess the effect of rTMS with different parameters (1/5/10 Hz, 0.84/1.26 T) on the depressive-like behaviors, 5-hydroxytryptamine (5-HT), 5-HIAA (5-hydroxyindoleacetic acid) and DA and NE levels, and monoamine oxidase A (MAO-A) activity in chronic unpredictable stress-treated rats, along with the expression of sirtuin 1 (Sirt1) and MAO-A in the prefrontal cortex (PFC) and cortex-derived astrocytes from new-born rats...
September 25, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28941198/porcine-circovirus-like-virus-p1-in-cattle-goats-and-rabbits-in-china
#13
L Wen, A Mao, Z Fan, W Li, Q Xiao, Q Liu, J Xie, K He
Porcine circovirus-like virus P1, a novel single-stranded circular DNA virus, is a potential causative agent of post-weaning multisystemic wasting syndrome in swine. In this study, we detected P1 strains in serum samples from cattle, goats and rabbits suffering different clinical symptoms, in Jiangsu Province, China. We sequenced the whole genomes of six P1 strains, which showed 99.4%-100% nucleotide sequence similarity and were closely related to other porcine-origin P1 isolates. The sequences of six non-porcine-origin P1 viruses were most closely phylogenetically related to other porcine-origin P1 sequences...
September 21, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28927796/development-and-evaluation-of-4-pyrrolidin-3-yl-benzonitrile-derivatives-as-inhibitors-of-lysine-specific-demethylase-1
#14
Daniel P Mould, Ulf Bremberg, Allan M Jordan, Matthis Geitmann, Alison E McGonagle, Tim C P Somervaille, Gary J Spencer, Donald J Ogilvie
As part of our ongoing efforts to develop reversible inhibitors of LSD1, we identified a series of 4-(pyrrolidin-3-yl)benzonitrile derivatives that act as successful scaffold-hops of the literature inhibitor GSK-690. The most active compound, 21g, demonstrated a Kd value of 22nM and a biochemical IC50 of 57nM. In addition, this compound displayed improved selectivity over the hERG ion channel compared to GSK-690, and no activity against the related enzymes MAO-A and B. In human THP-1 acute myeloid leukaemia cells, 21g was found to increase the expression of the surrogate cellular biomarker CD86...
October 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28916252/decreased-monoamine-oxidase-a-expression-and-activity-in-the-bladders-of-rats-with-partial-outlet-obstruction
#15
Mai Michishita, Kazuo Yano, Ken-Ichi Tomita, Satoru Yoshikawa, Osamu Matsuzaki, Ken-Ichi Kasahara
OBJECTIVE: To investigate changes in expression and activity of monoamine oxidase A (MAO-A) in rats with partial bladder outlet obstruction (pBOO). Previous studies suggested that monoamines, such as serotonin (5-hydroxytryptamine [5-HT]) and noradrenaline, are involved in bladder hyperactivity secondary to pBOO. However, little is known about the role of MAO-A, an enzyme oxidizing 5-hydroxytryptamine and noradrenalin, in the pathogenesis. MATERIALS AND METHODS: Female Sprague Dawley rats were subjected to sham or pBOO operations for 7 days, then their bladders were isolated...
September 12, 2017: Urology
https://www.readbyqxmd.com/read/28882179/medical-expenditure-for-esophageal-cancer-in-china-a-10-year-multicenter-retrospective-survey-2002-2011
#16
Lan-Wei Guo, Hui-Yao Huang, Ju-Fang Shi, Li-Hong Lv, Ya-Na Bai, A-Yan Mao, Xian-Zhen Liao, Guo-Xiang Liu, Jian-Song Ren, Xiao-Jie Sun, Xin-Yu Zhu, Jin-Yi Zhou, Ji-Yong Gong, Qi Zhou, Lin Zhu, Yu-Qin Liu, Bing-Bing Song, Ling-Bin Du, Xiao-Jing Xing, Pei-An Lou, Xiao-Hua Sun, Xiao Qi, Shou-Ling Wu, Rong Cao, Li Lan, Ying Ren, Kai Zhang, Jie He, Jian-Gong Zhang, Min Dai
BACKGROUND: Esophageal cancer is associated with substantial disease burden in China, and data on the economic burden are fundamental for setting priorities in cancer interventions. The medical expenditure for the diagnosis and treatment of esophageal cancer in China has not been fully quantified. This study aimed to examine the medical expenditure of Chinese patients with esophageal cancer and the associated trends. METHODS: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 37 hospitals in 13 provinces/municipalities across China as a part of the Cancer Screening Program of Urban China...
September 7, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28862601/-comparative-analysis-of-expression-of-genes-encoding-enzymes-of-catecholamine-catabolism-and-renalase-in-tissues-of-normotensive-and-hypertensive-rats
#17
V I Fedchenko, A E Medvedev
Comparative analysis of expression of genes encoding enzymes of catecholamine catabolism (monoaminbe oxidases A and B (MAO A and MAO B) and catechol-O-methyl transferase (COMT)) and renalase has been carried out in tissues of normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Among investigated tissues the highest level of mRNA of genes encoding key enzymes of catecholamine catabolism (MAO A, MAO B, COMT) was found in the heart of WKY rats. In SHR the mRNA levels of these genes were lower (p<0...
July 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/28857544/identification-of-5-1-methyl-5-trifluoromethyl-1h-pyrazol-3-yl-thiophene-2-carboxamides-as-novel-and-selective-monoamine-oxidase-b-inhibitors-used-to-improve-memory-and-cognition
#18
Alan P Kaplan, Terence Keenan, Roderick Scott, Xianbo Zhou, Rusiko Bourchouladze, Andrew J McRiner, Mark E Wilson, Darlene Romashko, Regina Miller, Matthew Bletsch, Gary Anderson, Jennifer Stanley, Adia Zhang, Dong Lee, John Nikpur
Initial work in Drosophila and mice demonstrated that the transcription factor cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) is a master control gene for memory formation. The relationship between CREB and memory has also been found to be true in other species, including aplysia and rats. It is thus well-established that CREB activation plays a central role in memory enhancement and that CREB is activated during memory formation. On the basis of these findings, a phenotypic high-throughput screening campaign utilizing a CRE-luciferase (CRE-Luci) SK-N-MC cell line was performed to identify compounds that enhance transcriptional activation of the CRE promoter with a suboptimal dose of forskolin...
September 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28851912/association-of-monoamine-oxidase-a-genetic-variants-and-amygdala-morphology-in-violent-offenders-with-antisocial-personality-disorder-and-high-psychopathic-traits
#19
Nathan J Kolla, Raihaan Patel, Jeffrey H Meyer, M Mallar Chakravarty
Violent offending is elevated among individuals with antisocial personality disorder (ASPD) and high psychopathic traits (PP). Morphological abnormalities of the amygdala and orbitofrontal cortex (OFC) are present in violent offenders, which may relate to the violence enacted by ASPD + PP. Among healthy males, monoamine oxidase-A (MAO-A) genetic variants linked to low in vitro transcription (MAOA-L) are associated with structural abnormalities of the amygdala and OFC. However, it is currently unknown whether amygdala and OFC morphology in ASPD relate to MAO-A genetic polymorphisms...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28839357/using-molecular-docking-analysis-to-discovery-dregea-sinensis-hemsl-potential-mechanism-of-anticancer-antidepression-and-immunoregulation
#20
Xiujie Liu, Yu Shi, Yulin Deng, Rongji Dai
BACKGROUND: Dregea sinensis Hemsl. plant of the genus Dregea volubilis (Asclepiadaceae), plays a vital role in anticancer, antidepression, and immunoregulation. Steroidal glycosides are the main constituents of this herb, which were significant biological active ingredients. OBJECTIVE: The objective of this study is to recognize the mechanism of anticancer, antidepression, and immunoregulation of D. sinensis Hemsl. MATERIALS AND METHODS: Seventy-two steroidal glycosides of D...
July 2017: Pharmacognosy Magazine
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