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https://www.readbyqxmd.com/read/29765503/oleuropein-aglycone-protects-against-mao-a-induced-autophagy-impairment-and-cardiomyocyte-death-through-activation-of-tfeb
#1
Caterina Miceli, Yohan Santin, Nicola Manzella, Raffaele Coppini, Andrea Berti, Massimo Stefani, Angelo Parini, Jeanne Mialet-Perez, Chiara Nediani
Age-associated diseases such as neurodegenerative and cardiovascular disorders are characterized by increased oxidative stress associated with autophagy dysfunction. Oleuropein aglycone (OA), the main polyphenol found in olive oil, was recently characterized as an autophagy inducer and a promising agent against neurodegeneration. It is presently unknown whether OA can have beneficial effects in a model of cardiac stress characterized by autophagy dysfunction. Here, we explored the effects of OA in cardiomyocytes with overexpression of monoamine oxidase-A (MAO-A)...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29761653/detection-of-porcine-circovirus-like-virus-p1-in-hebei-china
#2
L Wen, A Mao, F Jiao, D Zhang, J Xie, K He
Porcine circovirus-like virus P1 is a novel unclassified circovirus that was first detected in China and may be associated with post-weaning multisystemic wasting syndrome (PMWS) and congenital tremor. In this study, we detected P1 infection in pigs in Hebei Province, China, in 2017. One hundred and forty of 500 (28.0%) serum samples from 25 pig farms with different PMWS status in seven cities were P1 positive on PCR. Twelve P1 strains were sequenced, and the complete genomes of 11 P1 strains were 648 nucleotides (nt) in length, whereas that of strain ZJK02 was 647 nt, with a G deletion at position of 183 in its genome...
May 14, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29758567/synthesis-and-in-vitro-evaluation-of-2-heteroarylidene-1-tetralone-derivatives-as-monoamine-oxidase-inhibitors
#3
Klaudia T Amakali, Lesetja J Legoabe, Anél Petzer, Jacobus P Petzer
The present study investigates the human monoamine oxidase (MAO) inhibition properties of a series of twelve 2-heteroarylidene-1-tetralone derivatives. Also included are related cyclohexylmethylidene, cyclopentylmethylidene and benzylidene substituted 1-tetralones. These compounds are related to the 2-benzylidene-1-indanone class of compounds which has previously been shown to inhibit the MAOs, with specificity for the MAO-B isoform. The target compounds were synthesised by the Claisen-Schmidt condensation between 7-methoxy-1-tetralone or 1-tetralone, and various aldehydes, under acid (hydrochloric acid) or base (potassium hydroxide) catalysis...
May 14, 2018: Drug Research
https://www.readbyqxmd.com/read/29748850/from-aggression-to-autism-new-perspectives-on-the-behavioral-sequelae-of-monoamine-oxidase-deficiency
#4
REVIEW
Marco Bortolato, Gabriele Floris, Jean C Shih
The two monoamine oxidase (MAO) enzymes, A and B, catalyze the metabolism of monoamine neurotransmitters, such as serotonin, norepinephrine, and dopamine. The phenotypic outcomes of MAO congenital deficiency have been studied in humans and animal models, to explore the role of these enzymes in behavioral regulation. The clinical condition caused by MAOA deficiency, Brunner syndrome, was first described as a disorder characterized by overt antisocial and aggressive conduct. Building on this discovery, subsequent studies were focused on the characterization of the role of MAOA in the neurobiology of antisocial conduct...
May 10, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29746646/corticostriatal-connectivity-in-antisocial-personality-disorder-by-mao-a-genotype-and-its-relationship-to-aggressive-behavior
#5
Nathan J Kolla, Katharine Dunlop, Jeffrey H Meyer, Jonathan Downar
Background: The influence of genetic variation on resting-state neural networks represents a burgeoning line of inquiry in psychiatric research. Monoamine oxidase A, an X-linked gene, is one example of a molecular target linked to brain activity in psychiatric illness. Monoamine oxidase A genetic variants, including the high and low variable nucleotide tandem repeat polymorphisms, have been shown to differentially affect brain functional connectivity in healthy humans. However, it is currently unknown whether these same polymorphisms influence resting-state brain activity in clinical conditions...
May 9, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29743852/n1-benzenesulfonyl-2-pyrazoline-hybrids-in-neurological-disorders-syntheses-biological-screening-and-computational-studies
#6
Avinash C Tripathi, Savita Upadhyay, Sarvesh Paliwal, Shailendra K Saraf
A novel series of 1,3,5-trisubstituted-2-pyrazolines (5a-5t ) was prepared via Claisen Schmidt condensation, followed by heterocyclization with hydrazine hydrate, substitution of N1 hydrogen of 2-pyrazoline nucleus with 4-chlorobenzenesulfonylchloride, applying conventional and green chemistry approaches. Among the two, microwave assisted organic synthesis (MAOS) emerged as a better synthetic tool in terms of faster reaction rate and high yield. Various physicochemical and spectral studies were conducted to characterize the synthesized derivatives including- IR, Mass, 1 H-NMR, 13 C-NMR and elemental analysis...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29714148/synthesis-and-evaluation-of-2-benzylidene-1-tetralone-derivatives-for-monoamine-oxidase-inhibitory-activity
#7
Klaudia T Amakali, Lesetja Jan Legoabe, Anel Petzer, Jacobus P Petzer
Chalcone has been identified as a promising lead for the design of monoamine oxidase (MAO) inhibitors. This study attempted to discover potent and selective chalcone-derived MAO inhibitors by synthesising a series consisting of various cyclic chalcone derivatives. The cyclic chalcones were selected based on the possibility that their restricted structures would confer a higher degree of MAO isoform selectivity, and included the following chemical classes: 1-indanone, 1-tetralone, 1-benzosuberone, chromone, thiochromone, 4-chromanone and 4-thiochromanone...
May 1, 2018: Central Nervous System Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29696800/oxoisoaporphine-alkaloids-prospective-anti-alzheimer-s-anticancer-and-antidepression-agents
#8
Jiayao Zhang, Li Chen, Jianbo Sun
Oxoisoaporphine alkaloids are a family of oxoisoquinoline-derived alkaloids that have been firstly isolated from the rhizome of Menispermum dauricum DC. (Menispermaceae). It was demonstrated in some research that oxoisoaporphine alkaloids possess various biological properties, such as cholinesterase and β-amyloid (Aβ) inhibitory, acting as topoisomerase intercalator, monoamine oxidase A (MAO-A) inhibitory , etc, which are expected to become anti-Alzheimer's, anticancer and antidepression drugs. This review provides an overview on natural sources, synthetic route, bioactivities, structure-function relationship and modification investigation of oxoisoaporphine alkaloids, aiming to provide references of the structure-activity relationships for designing and development of oxoisoaporphine derivatives with higher efficacy and therapeutic potential...
April 25, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29695771/differential-expression-of-il-6-il-6r-and-mao-a-regulates-invasion-angiogenesis-in-breast-cancer
#9
Rashmi Bharti, Goutam Dey, Anjan Kumar Das, Mahitosh Mandal
BACKGROUND: Monoamine oxidases (MAO) are mitochondrial enzymes functioning in oxidative metabolism of monoamines. The action of MAO-A has been typically described in neuro-pharmacological domains. Here, we have established a co-relation between IL-6/IL-6R and MAO-A and their regulation in hypoxia induced invasion/angiogenesis. METHODS: We employed various in-vitro and in-vivo techniques and clinical samples. RESULTS: We studied a co-relation among MAO-A and IL-6/IL-6R and tumour angiogenesis/invasion in hypoxic environment in breast cancer model...
April 26, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29671581/novel-mao-b-hit-inhibitors-using-multidimensional-molecular-modeling-approaches-and-application-of-binary-qsar-models-for-prediction-of-their-therapeutic-activity-and-toxic-effects
#10
Yusuf Serhat Is, Serdar Durdagi, Busecan Aksoydan, Mine Yurtsever
Monoamine oxidase (MAO) enzymes MAO-A and MAO-B play a critical role in the metabolism of monoamine neurotransmitters. Hence, MAO inhibitors are very important for the treatment of several neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS). In this study, 256750 molecules from Otava Green Chemical Collection were virtually screened for their binding activities as MAO-B inhibitors. Two hit molecules were identified after applying different filters such as high docking scores and selectivity to MAO-B, desired pharmacokinetic profile predictions with binary QSAR models...
April 19, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29665788/medical-expenses-of-urban-chinese-patients-with-stomach-cancer-during-2002-2011-a-hospital-based-multicenter-retrospective-study
#11
Xiao-Jie Sun, Ju-Fang Shi, Lan-Wei Guo, Hui-Yao Huang, Neng-Liang Yao, Ji-Yong Gong, Ya-Wen Sun, Guo-Xiang Liu, A-Yan Mao, Xian-Zhen Liao, Ya-Na Bai, Jian-Song Ren, Xin-Yu Zhu, Jin-Yi Zhou, Ling Mai, Bing-Bing Song, Yu-Qin Liu, Lin Zhu, Ling-Bin Du, Qi Zhou, Xiao-Jing Xing, Pei-An Lou, Xiao-Hua Sun, Xiao Qi, Yuanzheng Wang, Rong Cao, Ying Ren, Li Lan, Kai Zhang, Jie He, Jia-Lin Wang, Min Dai
BACKGROUND: In China, stomach cancer is the third most common cancer and the third leading cause of cancer death. Few studies have examined Chinese stomach cancer patients' medical expenses and their associated trends. The Cancer Screening Program in Urban China (CanSPUC) is a Major Public Health Project funded by the central government. Through this project, we have extracted patients' medical expenses from hospital billing data to examine the costs of the first course treatments (which refers to 2 months before and 10 months after the date of cancer diagnosis) in Chinese patients with stomach cancer and the associated trends...
April 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29655691/functionalized-liposomes-and-phytosomes-loading-annona-muricata-l-aqueous-extract-potential-nanoshuttles-for-brain-delivery-of-phenolic-compounds
#12
Simona Mancini, Luca Nardo, Maria Gregori, Inês Ribeiro, Francesco Mantegazza, Cristina Delerue-Matos, Massimo Masserini, Clara Grosso
BACKGROUND: Multi-target drugs have gained significant recognition for the treatment of multifactorial diseases such as depression. Under a screening study of multi-potent medicinal plants with claimed antidepressant-like activity, the phenolic-rich Annona muricata aqueous extract (AE) emerged as a moderate monoamine oxidase A (hMAO-A) inhibitor and a strong hydrogen peroxide (H2 O2 ) scavenger. PURPOSE: In order to protect this extract from gastrointestinal biotransformation and to improve its permeability across the blood-brain barrier (BBB), four phospholipid nanoformulations of liposomes and phytosomes functionalized with a peptide ligand promoting BBB crossing were produced...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29609242/-constituent-and-workload-of-service-providers-engaged-in-cancer-screening-findings-and-suggestions-from-a-multi-center-survey-in-china
#13
Z X Sun, J F Shi, L Lan, A Y Mao, H Y Huang, H K Lei, W Q Qiu, P Dong, J Zhu, D B Wang, G X Liu, Y N Bai, X J Sun, X Z Liao, J S Ren, L W Guo, Q Zhou, L Yang, B B Song, L B Du, L Zhu, J Y Gong, Y Q Liu, Y Ren, L Mai, M F Qin, Y Z Zhang, J Y Zhou, X H Sun, S L Wu, X Qi, P A Lou, B Cai, K Zhang, J He, M Dai
Objective: To understand the constituent and workload of service providers engaged in cancer screening in China and provide evidence for the assessment of the sustainability of national cancer screening project. Methods: Using either questionnaire or online approach, the survey was conducted in 16 provinces, where Cancer Screening Program in Urban China (CanSPUC) was conducted, from 2014 to 2015. The medical institutes surveyed included hospitals [71.1% were class Ⅲ(A) hospitals], centers for disease control and prevention (CDCs) and community centers where cancer screening was undertaken during 2013-2015...
March 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29609241/-potential-demand-on-cancer-screening-service-in-urban-populations-in-china-a-cross-sectional-survey
#14
H K Lei, P Dong, Q Zhou, W Q Qiu, Z X Sun, H Y Huang, J S Ren, G X Liu, Y N Bai, D B Wang, X J Sun, X Z Liao, L W Guo, L Lan, Y Q Liu, J Y Gong, L Yang, X J Xing, B B Song, L Mai, L Zhu, L B Du, Y Z Zhang, J Y Zhou, M F Qin, S L Wu, X Qi, X H Sun, P A Lou, B Cai, K Zhang, J He, M Dai, A Y Mao, J F Shi
Objective: To understand the acceptance and personal demand for cancer screening service among the urban residents who had never been involved in any national level cancer screening programs in China and identify the key factors influencing the sustainability of cancer screening. Methods: A questionnaire survey was conducted among the local people aged 40-69 years selected through convenience sampling in 16 provinces of China to collect the general information about their demands for the screening service and others...
March 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29597131/health-related-quality-of-life-and-utility-scores-of-patients-with-breast-neoplasms-in-china-a-multicenter-cross-sectional-survey
#15
Le Wang, Ju-Fang Shi, Juan Zhu, Hui-Yao Huang, Ya-Na Bai, Guo-Xiang Liu, Xian-Zhen Liao, A-Yan Mao, Jian-Song Ren, Xiao-Jie Sun, Lan-Wei Guo, Yi Fang, Qi Zhou, Heng-Min Ma, Xiao-Jing Xing, Lin Zhu, Bing-Bing Song, Ling-Bin Du, Ling Mai, Yu-Qin Liu, Ying Ren, Li Lan, Jin-Yi Zhou, Xiao Qi, Xiao-Hua Sun, Pei-An Lou, Shou-Ling Wu, Ni Li, Kai Zhang, Jie He, Min Dai
BACKGROUND: Health-related quality of life and utility scores of patients with breast cancer and precancerous lesions are sparse in China. This study aimed to derive utility scores of patients with breast cancer and precancer in China. MATERIAL AND METHODS: An interviewer-administered cross-sectional survey was conducted in 12 provinces across China from 2013 to 2014. The three-level EuroQol-5-Dimension instrument was used to evaluate quality of life, and utility scores were generated using the Chinese value set...
March 26, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29570223/an-investigation-of-the-monoamine-oxidase-inhibition-properties-of-pyrrolo-3-4-f-indole-5-7-dione-and-indole-5-6-dicarbonitrile-derivatives
#16
Zhanna V Chirkova, Mariya V Kabanova, Sergey I Filimonov, Igor G Abramov, Anél Petzer, Idalet Engelbrecht, Jacobus P Petzer, Kyrill Yu Suponitsky, Alexander V Veselovsky
Hit, Lead & Candidate Discovery In recent studies, we have shown that pyrrolo[3,4-f]indole-5,7-dione and indole-5,6-dicarbonitrile derivatives act as good potency in vitro inhibitors of the monoamine oxidase (MAO) enzymes. To expand on these series and to further derive structure-activity relationships (SARs) for MAO inhibition, in the present study we synthesized additional homologs and related analogs of these chemical classes. Analyzes of the MAO inhibition properties of the synthesized compounds show that among the pyrrolo[3,4-f]indole-5,7-dione derivatives good potency MAO inhibitors exist as exemplified by 10, which possesses IC50 values for the inhibition of MAO-A and MAO-B of 0...
March 23, 2018: Drug Development Research
https://www.readbyqxmd.com/read/29568754/monoamine-oxidase-a-inhibition-and-associated-antioxidant-activity-in-plant-extracts-with-potential-antidepressant-actions
#17
Tomás Herraiz, Hugo Guillén
Monoamine oxidase (MAO) catalyzes the oxidative deamination of amines and neurotransmitters and is involved in mood disorders, depression, oxidative stress, and adverse pharmacological reactions. This work studies the inhibition of human MAO-A by Hypericum perforatum , Peganum harmala, and Lepidium meyenii, which are reported to improve and affect mood and mental conditions. Subsequently, the antioxidant activity associated with the inhibition of MAO is determined in plant extracts for the first time. H. perforatum inhibited human MAO-A, and extracts from flowers gave the highest inhibition (IC50 of 63...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29561824/nutraceutical-potential-of-phenolics-from-brava-and-mansa-extra-virgin-olive-oils-on-the-inhibition-of-enzymes-associated-to-neurodegenerative-disorders-in-comparison-with-those-of-picual-and-cornicabra
#18
María Figueiredo-González, Patricia Reboredo-Rodríguez, Carmen González-Barreiro, Alegría Carrasco-Pancorbo, Jesús Simal-Gándara, Beatriz Cancho-Grande
The increasing interest in the Mediterranean diet is based on the protective effects against several diseases, including neurodegenerative disorders. Polyphenol-rich functional foods have been proposed to be unique supplementary and nutraceutical treatments for these disorders. Extra-virgin olive oils (EVOOs) obtained from 'Brava' and 'Mansa', varieties recently identified from Galicia (northwestern Spain), were selected for in vitro screening to evaluate their capacity to inhibit key enzymes involved in Alzheimer's disease (AD) (acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 5-lipoxygenase (5-LOX)), major depressive disorder (MDD) and Parkinson's disease (PD) (monoamine oxidases: h MAO-A and h MAO-B respectively)...
March 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29557505/differences-in-snp-genotype-distributions-between-complex-and-simple-suicides
#19
Tanja Čugura, Jakob Boh, Tomaž Zupanc, Peter Pregelj, Alja Videtič Paska
Dysregulations in serotonin neurotransmission can be a strong contributing factor in suicide and impulsive-aggressive personality traits. Victims of suicide form a heterogeneous group in terms of planning, lethality and number of used methods. In this study, we tested single nucleotide polymorphisms (SNPs) of the monoamine oxidase (MAO) A and B genes on the Slovenian population, which has one of the highest suicide rates in the world. Genotyping was performed on 77 victims of complex suicide, 406 victims of simple suicide and 289 controls...
March 20, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29552078/isolation-and-biological-evaluation-of-prenylated-flavonoids-from-maclura-pomifera
#20
Yerkebulan Orazbekov, Mohamed A Ibrahim, Serjan Mombekov, Radhakrishnan Srivedavyasasri, Ubaidilla Datkhayev, Bauyrzhan Makhatov, Narayan D Chaurasiya, Babu L Tekwani, Samir A Ross
Phytochemical analysis of the ethanolic extract of Maclura pomifera fruits yielded four new compounds ( I - IV ) along with eleven known compounds ( V - XV ). The crude extract exhibited significant activity towards cannabinoid receptors (CB1: 103.4% displacement; CB2: 68.8% displacement) and possibly allosteric interaction with δ and μ opioid receptors (-49.7 and -53.8% displacement, resp.). Compound I was found to be possibly allosteric for κ and μ opioid receptors (-88.4 and -27.2% displacement, resp...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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