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Christopher Mallow, Jeffrey Thiboutot, Roy Semaan, Margaret M Hayes, Russell Hales, Ashwin Ram, David Feller-Kopman, Hans Lee, Lonny Yarmus
BACKGROUND AND OBJECTIVE: Malignant airway obstruction (MAO), a common complication of patients with advanced lung cancer, causes debilitating dyspnoea and poor quality of life. Two common interventions used in the treatment of MAO include bronchoscopy with airway stenting and external beam radiotherapy (EBRT). Data are limited regarding their clinical effectiveness and overall effect on survival. METHODS: A retrospective chart review of patients treated with airway stenting and/or EBRT at the Johns Hopkins Hospital for MAO between July 2010 and January 2017 was reviewed...
March 12, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
Souravh Bais, Renu Kumari, Yash Prashar
BACKGROUND: sinapic acid (3, 5 di-methoxy 4-hydroxycinnamic acid) is a bioactive compound. Recent studies showed that it has a significant potential to attenuate various chemically induced Neurodegenerative toxicities. AIM: the present study investigates the potential of sinapic acid as neuromodulator and its effect on release of Monoamine Oxidase (MAO-A, MAO-B), TNF-α, Acetylcholine esterase Enzyme, in cognitive dysfunctions associated with experimental dementia...
March 9, 2018: CNS & Neurological Disorders Drug Targets
L Wen, A Mao, X Zhu, J Xie, K He
A large outbreak of swine abortion, which began in January 2017, is ongoing in Jiangsu and Anhui provinces, China. We identified a new porcine circovirus-like agent, designated P4, in the aborted foetuses from several of these cases of swine reproductive failure. PCR and qRT-PCR analyses confirmed that other common abortogenic agents were not present in these animals. P4 contains a 710-nucleotide circular viral genome, and all strains examined in this study were closely related to the dominant genotype of porcine circovirus type 2...
March 8, 2018: Transboundary and Emerging Diseases
Wu-Qi Qiu, Ju-Fang Shi, Lan-Wei Guo, A-Yan Mao, Hui-Yao Huang, Guang-Yu Hu, Pei Dong, Fang-Zhou Bai, Xiao-Ling Yan, Xian-Zhen Liao, Guo-Xiang Liu, Ya-Na Bai, Jian-Song Ren, Xiao-Jie Sun, Xin-Yu Zhu, Jin-Yi Zhou, Ji-Yong Gong, Lin Zhu, Ling Mai, Ling-Bing Du, Qi Zhou, Xiao-Jing Xing, Bing-Bing Song, Yu-Qin Liu, Pei-An Lou, Xiao-Hua Sun, Shou-Ling Wu, Rong Cao, Xiao Qi, Li Lan, Ying Ren, Kai Zhang, Jie He, Chunfeng Qu, Min Dai
Objective: This study aims to understand the medical expenditure for liver cancer during 2002-2011 in urban areas of China. Materials and Methods: This is a retrospective study. Based on a stratified cluster sampling method, a medical expenditure survey collected basic personal information from related medical records. Two-tailed independent sample t-test, variance analysis, and Student-Newman-Keuls Tests were used in cost analysis for the corresponding data types...
January 2018: Journal of Cancer Research and Therapeutics
Rona R Ramsay, Alen Albreht
Monoamine oxidases (MAOs) catalyse the oxidation of neurotransmitter amines and a wide variety of primary, secondary and tertiary amine xenobiotics, including therapeutic drugs. While inhibition of MAO activity in the periphery removes protection from biogenic amines and so is undesirable, inhibition in the brain gives vital antidepressant and behavioural advantages that make MAO a major pharmaceutical target for inhibitor design. In neurodegenerative diseases, MAO inhibitors can help to maintain neurotransmitter levels, making it a common feature in novel multi-target combinations designed to combat Alzheimer's disease, albeit not yet proven clinically...
March 7, 2018: Journal of Neural Transmission
Katarina Uršič, Tomaž Zupanc, Alja Videtič Paska
Suicide is a well-defined public health problem and is a complex phenomenon influenced by a number of different risk factors, including genetic ones. Numerous studies have examined serotonin system genes. Monoamine oxidase A (MAO-A) is an outer mitochondrial membrane enzyme which is involved in the metabolic pathway of serotonin degradation. Upstream variable number of tandem repeats (uVNTR) in the promoter region of MAOA gene affects the activity of transcription. In the present study we genotyped MAOA-uVNTR polymorphism in 266 suicide victims and 191 control subjects of Slovenian population, which ranks among the European and world populations with the highest suicide rate...
March 2, 2018: Neuroscience Letters
Sule Erol Gunal, Senel Teke Tuncel, Nesrin Gokhan Kelekci, Gulberk Ucar, Basak Yuce Dursun, Safiye Sag Erdem, Ilknur Dogan
Single enantiomers of the new 5-methyl-3-aryloxazolidine-2,4-diones have been obtained either by an asymmetric synthesis using the chiral pool strategy or by a semipreparative resolution of the racemic compound by HPLC on an optically active stationary phase. The single enantiomers were assayed for their in vitro monoamine oxidase (hMAO) inhibitory activity and selectivity. The most potent inhibitor among the studied compounds has been found as (5R)-3-phenyl-5-methyl-2,4-oxazolidinedione (compound 1-R) which appeared to be a good antidepressant drug candidate since it inhibited hMAO-A selectively, competitively and reversibly with Ki values in the micromolar range (0...
February 10, 2018: Bioorganic Chemistry
Rui Xu, Ganyuan Xiao, Yan Li, Hongyan Liu, Qing Song, Xiaoyu Zhang, Ziyi Yang, Yunxiaozhu Zheng, Zhenghuai Tan, Yong Deng
A series of 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives were designed, synthesized and evaluated as potential multifunctional agents for the treatment of Alzheimer's disease (AD). The in vitro assays indicated that most of these derivatives were selective AChE inhibitors with good multifunctional properties. Among them, compounds 11b and 11d displayed comprehensive advantages, with good AChE (IC50  = 0.29 ± 0.01 μM and 0.46 ± 0.02 μM, respectively), MAO-A (IC50  = 8...
February 21, 2018: Bioorganic & Medicinal Chemistry
Farida Larit, Khaled M Elokely, Narayan D Chaurasiya, Samira Benyahia, Manal A Nael, Francisco León, Mohammad Sanad Abu-Darwish, Thomas Efferth, Yan-Hong Wang, Djamila Belouahem-Abed, Samir Benayache, Babu L Tekwani, Stephen J Cutler
BACKGROUND: Monoamine oxidases (MAOs) are outer mitochondrial membrane flavoenzymes. They catalyze the oxidative deamination of a variety of neurotransmitters. MAO-A and MAO-B may be considered as targets for inhibitors to treat neurodegenerative diseases and depression and for managing symptoms associated with Parkinson's and Alzheimer's diseases. PURPOSE: The objective was to evaluate the inhibitory effect of Hypericum afrum and Cytisus villosus against MAO-A and B and to isolate the compounds responsible for the MAO-inhibitory activity...
February 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
P Dong, W Q Qiu, J F Shi, A Y Mao, H Y Huang, Z X Sun, J W Huang, X Z Liao, G X Liu, D B Wang, Y N Bai, X J Sun, J S Ren, L W Guo, L Lan, Y Q Liu, J Y Gong, L Yang, X J Xing, B B Song, Q Zhou, L Mai, L Zhu, L B Du, Y Z Zhang, J Y Zhou, M F Qin, S L Wu, X Qi, X H Sun, P A Lou, B Cai, K Zhang, J He, M Dai
Objective: To explore the sustainability of cancer screening strategy from potential demander's perspective in Chinese country, we conducted a study on the use of cancer screening services and willingness-to-pay among the urban community residents. All the participants of this study had not been on the Cancer Screening Program in Urban China (CanSPUC) or any other national level cancer screening projects. Methods: Target communities and populations were selected from the 16 project provinces in China which were on the program between 2014 and 2015, by using the multi-center cross-sectional convenience sampling method...
February 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
J Zhu, H Y Huang, A Y Mao, Z X Sun, W Q Qiu, H K Lei, P Dong, J W Huang, Y N Bai, X J Sun, G X Liu, D B Wang, X Z Liao, J S Ren, L W Guo, L Lan, Q Zhou, B B Song, Y Q Liu, L B Du, L Zhu, R Cao, J L Wang, L Mai, Y Ren, J Y Zhou, X H Sun, S L Wu, X Qi, P A Lou, B Cai, N Li, K Zhang, J He, M Dai, J F Shi
Objective: From an actual cancer screening service demanders' perspective, we tried to understand the preference on screening frequency and willingness-to-pay for the packaging screening program on common cancers and to evaluate its long-term sustainability in urban populations in China. Methods: From 2012 to 2014, a multi-center cross-sectional survey was conducted among the actual screening participants from 13 provinces covered by the Cancer Screening Program in Urban China (CanSPUC). By face-to-face interview, information regarding to preference to screening frequency, willingness-to-pay for packaging screening program, maximum amount on payment and related reasons for unwillingness were investigated...
February 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
A Y Mao, J F Shi, W Q Qiu, P Dong, Z X Sun, H Y Huang, X J Sun, G X Liu, D B Wang, Y N Bai, X Z Liao, J S Ren, L W Guo, L Lan, Q Zhou, J Y Zhou, L Yang, J L Wang, M F Qin, Y Z Zhang, B B Song, X J Xing, L Zhu, L Mai, L B Du, Y Q Liu, P A Lou, B Cai, X H Sun, S L Wu, X Qi, K Zhang, J He, M Dai
Objective: Based on the investment for potential suppliers of cancer screening services, we assessed the reasons that affecting their participation motivation related to the long-term sustainability of cancer screening in China. Methods: Hospitals that had never been involved in any national level cancer screening project were selected by using the convenient sampling method within the 16 project cities of Cancer Screening Program in Urban China (CanSPUC) with 1 or 2 hospitals for each city. All the managers from the institutional/department level and professional staff working and providing screening services in these hospitals, were interviewed by paper-based questionnaire...
February 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
J F Shi, A Y Mao, Z X Sun, H K Lei, W Q Qiu, H Y Huang, P Dong, J W Huang, J Zhu, J Li, G X Liu, D B Wang, Y N Bai, X J Sun, X Z Liao, J S Ren, L W Guo, L Lan, Q Zhou, L Yang, B B Song, L B Du, L Zhu, J L Wang, Y Q Liu, Y Ren, L Mai, M F Qin, Y Z Zhang, J Y Zhou, X H Sun, S L Wu, X Qi, P A Lou, B Cai, N Li, K Zhang, J He, M Dai
Objective: From the perspective of actual service suppliers regarding cancer screening, this study aimed to assess the long-term sustainability of cancer screening programs in China. Methods: Based on a Cancer Screening Program in Urban China (CanSPUC), our survey focused on all the hospitals, centers for disease control and prevention (CDC) and community service centers across 16 provinces in China which participated in the programs between 2013 and 2015. All the managers (institutional/department level) and professional staff involved in the program were interviewed using either paper-based questionnaire or online approach...
February 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
M Dai, A Y Mao, J F Shi
In a real-world running of cancer screening programs or intervention strategies, multiple influencing factors need to be considered other than the effectiveness and cost-effectiveness. The articles in this special issue summarize the main findings related to sustainability of cancer screening program in urban China from four perspectives of cancer screening service, including actual supplier, potential supplier, actual demander and potential demander. These evidences are expected to provide references for decision-making on suitable strategies and running mechanism for large-scale cancer screening program in local populations...
February 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Robert S Ross, Andrew Smolen, Tim Curran, Erika Nyhus
A critical problem for developing personalized treatment plans for cognitive disruptions is the lack of understanding how individual differences influence cognition. Recognition memory is one cognitive ability that varies from person to person and that variation may be related to different genetic phenotypes. One gene that may impact recognition memory is the monoamine oxidase A gene ( MAO-A ), which influences the transcription rate of MAO-A. Examination of how MAO-A phenotypes impact behavioral and event-related potentials (ERPs) correlates of recognition memory may help explain individual differences in recognition memory performance...
2018: Frontiers in Human Neuroscience
Anna Affini, Stefanie Hagenow, Aleksandra Zivkovic, Jose Marco-Contelles, Holger Stark
The design of multi-targeting ligands was developed in the last decades as an innovative therapeutic concept for Parkinson's disease (PD) and other neurodegenerative disorders. As the monoamine oxidase B (MAO B) and the histamine H3 receptor (H3 R) are promising targets for dopaminergic regulation, we synthetized dual-targeting ligands (DTLs) as non-dopaminergic receptor approach for the treatment of PD. Three series of compounds were developed by attaching the H3 R pharmacophore to indanone-related MAO B motifs, leading to development of MAO B/H3 R DTLs...
February 16, 2018: European Journal of Medicinal Chemistry
Dale E Edmondson, Claudia Binda
Monoamine oxidases A and B (MAO A and B) are mammalian flavoenzymes bound to the outer mitochondrial membrane. They were discovered almost a century ago and they have been the subject of many biochemical, structural and pharmacological investigations due to their central role in neurotransmitter metabolism. Currently, the treatment of Parkinson's disease involves the use of selective MAO B inhibitors such as rasagiline and safinamide. MAO inhibition was shown to exert a general neuroprotective effect as a result of the reduction of oxidative stress produced by these enzymes, which seems to be relevant also in non-neuronal contexts...
2018: Sub-cellular Biochemistry
Dai-Hua Lu, Hsiao-Mei Liao, Chia-Hsiang Chen, Huang-Ju Tu, Houng-Chi Liou, Susan Shur-Fen Gau, Wen-Mei Fu
Background: Impaired social interaction is one of the essential features of autism spectrum disorder (ASD). Our previous copy number variation (CNV) study discovered a novel deleted region associated with ASD. One of the genes included in the deleted region is ARHGEF10 . A missense mutation of ARHGEF10 has been reported to be one of the contributing factors in several diseases of the central nervous system. However, the relationship between the loss of ARHGEF10 and the clinical symptoms of ASD is unclear...
2018: Molecular Autism
Koichi Takao, Hideaki Yahagi, Yoshihiro Uesawa, Yoshiaki Sugita
A series of novel 3-(E)-styryl-2H-chromene derivatives were synthesized and their monoamine oxidase (MAO) A and B inhibitory activities were evaluated. All compounds exhibited no inhibitory activity towards MAO-A at 10 μM whereas compounds 1-5, 7, 9, 11-13, 15 and 16 showed strong inhibitory activity towards MAO-B at this concentration. Of these, compound 3, which contains fluorine at R 3 , showed the highest activity (IC 50 = 10 nM), and is about 22-fold more potent than pargyline (used as a positive control)...
February 7, 2018: Bioorganic Chemistry
Xiaoping Sun, Fangfang Zhu, Jun Zhou, Xiujuan Chang, Liang Li, Hanfei Hu, Zhenzhong Wang, Wei Xiao
BACKGROUND: Tianshu capsule(TSC)is a Chinese patent medicine. It's widely used to treat migraine clinically in China. AIM OF THE STUDY: In the present study, we investigated anti-migraine and anti-depression activities of TSC using in vivo animal models together with in vitro studies to investigate the mechanism of action. MATERIALS AND METHODS: Nitroglycerin (NTG) -induced migraine rat model, rat was given a subcutaneous injection of the NTG suspension (10 mg/kg) once a week for 5 weeks...
February 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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