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https://www.readbyqxmd.com/read/29149635/the-association-between-adolescent-cannabis-use-and-anxiety-a-parallel-process-analysis
#1
Jacqueline Duperrouzel, Samuel W Hawes, Catalina Lopez-Quintero, Ileana Pacheco-Colón, Jonathan Comer, Raul Gonzalez
INTRODUCTION: Associations between anxiety symptoms and cannabis use have been previously explored, yet the directionality of these associations remains highly debatable. The present study aims to prospectively examine patterns of cannabis use and anxiety during adolescence focusing on their co-development and bidirectional influences. METHODS: Adolescents (n=250) of predominantly Hispanic ethnicity, aged 14-17 at baseline, exposed to drugs, alcohol, or cigarettes completed three (bi-annual) assessments across a 1-year period...
November 4, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29149510/transferrin-as-a-predictor-of-survival-in-cirrhosis
#2
André Viveiros, Armin Finkenstedt, Benedikt Schaefer, Mattias Mandorfer, Bernhard Scheiner, Konrad Lehner, Moritz Tobiasch, Thomas Reiberger, Herbert Tilg, Michael Edlinger, Heinz Zoller
BACKGROUND AND AIMS: Patients with cirrhosis frequently present with high serum ferritin and low transferrin concentrations, reflecting impaired liver function and inflammation. Recent studies have shown that transferrin and its saturation with iron are MELD-independent predictors of mortality in patients with acute on chronic liver failure or decompensated cirrhosis. The aim of this study was to evaluate the prognostic utility of serum iron parameters in relation to markers of liver function and immune activation...
November 17, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29149493/impact-of-chronic-hepatitis-c-virus-infection-on-the-survival-of-patients-with-oropharyngeal-cancer
#3
Minas P Economides, Moran Amit, Parag S Mahale, Jeff J Hosry, Ying Jiang, Uddalak Bharadwaj, Erich M Sturgis, Harrys A Torres
BACKGROUND: Although an association between hepatitis C virus (HCV) infection and oropharyngeal cancers (OPCs) has been reported, to the authors' knowledge the clinical significance of this epidemiological finding remains unknown. Therefore, the authors analyzed the oncologic outcomes of HCV-infected patients with OPCs. METHODS: In this retrospective cohort study, all patients with OPCs who were seen at The University of Texas MD Anderson Cancer Center between January 2004 and December 2015 were reviewed...
November 17, 2017: Cancer
https://www.readbyqxmd.com/read/29149179/postmenopausal-hormone-therapy-and-risk-of-stroke-a-pooled-analysis-of-data-from-population-based-cohort-studies
#4
Germán D Carrasquilla, Paolo Frumento, Anita Berglund, Christer Borgfeldt, Matteo Bottai, Chiara Chiavenna, Mats Eliasson, Gunnar Engström, Göran Hallmans, Jan-Håkan Jansson, Patrik K Magnusson, Peter M Nilsson, Nancy L Pedersen, Alicja Wolk, Karin Leander
BACKGROUND: Recent research indicates a favourable influence of postmenopausal hormone therapy (HT) if initiated early, but not late, on subclinical atherosclerosis. However, the clinical relevance of timing of HT initiation for hard end points such as stroke remains to be determined. Further, no previous research has considered the timing of initiation of HT in relation to haemorrhagic stroke risk. The importance of the route of administration, type, active ingredient, and duration of HT for stroke risk is also unclear...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29148929/web-based-alcohol-intervention-in-first-year-college-students-efficacy-of-full-program-administration-prior-to-second-semester
#5
Rebecca J Gilbertson, Tina R Norton, Susan H Beery, Kassandra R Lee
BACKGROUND: Commercially available, web-based interventions for the prevention of alcohol use are being adopted for universal use with first-year college students, yet few have received empirical evaluation. OBJECTIVES: This randomized controlled trial investigated the effectiveness of a novel, commercially available, personalized web-based alcohol intervention, Alcohol-Wise (version 4.0, 3(rd) Millennium Classrooms), on multiple measures of alcohol consumption, alcohol consequences, alcohol expectancies, academic achievement, and adaptation to college in first-year students...
November 17, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29148806/discovery-of-tropifexor-ljn452-a-highly-potent-non-bile-acid-fxr-agonist-for-the-treatment-of-cholestatic-liver-diseases-and-nonalcoholic-steatohepatitis-nash
#6
David C Tully, Paul V Rucker, Donatella Chianelli, Jennifer Williams, Agnes Vidal, Phil B Alper, Daniel Mutnick, Badry Bursulaya, James Schmeits, Xiangdong Wu, Dingjiu Bao, Jocelyn Zoll, Young Kim, Todd Groessl, Peter McNamara, H Martin Seidel, Valentina Molteni, Bo Liu, Andrew Phimister, Sean B Joseph, Bryan Laffitte
The farnesoid X receptor (FXR) is a nuclear receptor that acts as a master regulator of bile acid metabolism and signaling. Activation of FXR inhibits bile acid synthesis and increases bile acid conjugation, transport, and excretion, thereby protecting the liver from the harmful effects of bile accumulation, leading to considerable interest in FXR as a therapeutic target for the treatment of cholestasis and non-alcoholic steatohepatitis. We identified a novel series of highly potent non-bile acid FXR agonists that introduce a bicyclic nortropine-substituted benzothiazole carboxylic acid moiety onto a trisubstituted isoxazole scaffold...
November 16, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29148775/gold-catalyzed-synthesis-of-substituted-3-trifluoromethylpyrroles-from-mesylated-amino-trifluoromethylpropargylic-alcohols
#7
Benjamin Guieu, Myriam Le Roch, Michèle David, Nicolas Gouault
A series of substituted 3-trifluoromethylpyrroles was obtained from trifluoromethyl-amino-ynol derivatives via a gold-catalyzed cyclization. These fluorinated starting materials, after mesylation allowed for the obtention of the desired compounds in good yields under mild conditions.
November 17, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29148749/glycosyl-cross-coupling-of-anomeric-nucleophiles-scope-mechanism-and-applications-in-the-synthesis-of-aryl-c-glycosides
#8
Feng Zhu, Jacob Rodriguez, Tianyi Yang, Ilia Kevlishvili, Eric Miller, Duk Yi, Sloane O'Neill, Michael Rourke, Peng Liu, Maciej A Walczak
Stereoselective manipulations at the C1 anomeric position of saccharides are one of the central goals of preparative carbohydrate chemistry. Historically, the majority of reactions forming a bond with anomeric carbon has focused on reactions of nucleophiles with saccharide donors equipped with a leaving group. Here, we describe a novel approach to stereoselective synthesis of C-aryl glycosides capitalizing on the highly stereospecific reaction of anomeric nucleophiles. First, methods for the preparation of anomeric stannanes have been developed and optimized to afford both anomers of common saccharides in high anomeric selectivities...
November 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29148637/psychoactive-substance-use-among-nigerian-cohort-with-hiv-aids-frequency-types-and-demographic-correlates
#9
Andrew Toyin Olagunju, Olasimbo Adenike Ogundipe, Tinuke Oluwasefunmi Olagunju, Oluseyi Ayodeji Campbell, Olatunji Francis Aina, Alani Sulaimon Akanmu
Introduction: There are good pointers from literature to the detrimental impacts of psychoactive substance use in HIV/AIDS patients. This study aimed at investigating the prevalence, types and demographic correlates of psychoactive substance use among people living with HIV/AIDS. Methods: The study participants consisted of 295 adults with HIV/AIDS and were interviewed with a designed questionnaire that consisted of two parts. The first part contained questions to elicit socio-demographic and treatment related information of the participants, while the second part focused on psychoactive substance use...
January 2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/29148266/nad-dependent-dehydrogenase-pctp-and-plp-dependent-aminotransferase-pctc-catalyze-the-first-post-glycosylation-modification-of-sugar-intermediate-in-pactamycin-biosynthesis
#10
Akane Hirayama, Jinmiao Chu, Ena Goto, Fumitaka Kudo, Tadashi Eguchi
The unique five-membered aminocyclitol core of the antitumor antibiotic pactamycin originates from D-glucose, so unprecedented enzymatic modifications of the sugar intermediate are involved in the biosynthesis. However, the order of the modification reactions remains elusive. Here, we examined the timing of introduction of an amino group into certain sugar-derived intermediates using recombinant enzymes that are encoded in the pactamycin biosynthesis gene cluster. We found that the NAD+-dependent alcohol dehydrogenase PctP and pyridoxal 5'-phosphate-dependent aminotransferase PctC convert N-acetyl-D-glucosaminyl-3-aminoacetophonone to 3'-amino-3'-deoxy-GlcNAc-3AAP...
November 17, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29148175/treatment-efficacy-of-a-probiotic-preparation-for-non-alcoholic-steatohepatitis-a-pilot-trial
#11
Elina Manzhalii, Oleksandr Virchenko, Tetyana Falalyeyeva, Tetyana Beregova, Wolfgang Stremmel
AIM: To evaluate the therapeutic effect of a probiotic cocktail containing lactobacilli, bifidobacteria, and Streptococcus thermophilus on non-alcoholic steatohepatitis (NASH). METHODS: In this open-label trial, 75 patients with NASH fed a low-fat/low-calorie diet were randomly divided into the control group (n = 37) and the experimental group (n = 38) also receiving the probiotic cocktail once daily for 12 weeks. RESULTS: All patients were diagnosed with fatty liver by ultrasound examination and had elevated levels of gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT), and slightly increased body mass index (BMI) and cholesterol levels...
November 17, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29148088/effectiveness-of-an-intensive-intervention-to-improve-lifestyles-in-subjects-with-intermediate-cardiovascular-risk-date-study-study-protocol-for-a-randomized-controlled-trial
#12
Natalia Sanchez-Aguadero, Sara Mora-Simon, Jose I Recio-Rodriguez, Rosario Alonso-Dominguez, Jesus Gonzalez-Sanchez, Cristina Martin-Martin, Manuel A Gomez-Marcos, Emiliano Rodriguez-Sanchez
AIM: To evaluate the effectiveness of an intensive intervention led by primary care nurses for lifestyle modification among subjects with intermediate cardiovascular risk. BACKGROUND: Cardiovascular diseases may be prevented by adopting healthy lifestyles. Interventions focused on populations at risk are more efficient than those aimed at the general population. More than 50 per cent of cardiovascular events occur in subjects with intermediate cardiovascular risk, but only a few studies have targeted this population...
November 17, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29147950/mental-health-consultation-among-ontario-s-immigrant-populations
#13
Farah Islam, Nazilla Khanlou, Alison Macpherson, Hala Tamim
To determine the prevalence rates and characteristics of past-year mental health consultation for Ontario's adult (18 + years old) immigrant populations. The Canadian Community Health Survey (CCHS) 2012 was used to calculate the prevalence rates of past-year mental health consultation by service provider type. Characteristics associated with mental health consultation were determined by carrying out multivariable logistic regression analysis on merged CCHS 2008-2012 data. Adult immigrant populations in Ontario (n = 3995) had lower estimated prevalence rates of past-year mental health consultation across all service provider types compared to Canadian-born populations (n = 14,644)...
November 16, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/29147940/interaction-of-proteins-with-ionic-liquid-alcohol-and-dmso-and-in-situ-generation-of-gold-nano-clusters-in-a-cell
#14
REVIEW
Somen Nandi, Sridip Parui, Ritaban Halder, Biman Jana, Kankan Bhattacharyya
In this review, we give a brief overview on how the interaction of proteins with ionic liquids, alcohols and dimethyl sulfoxide (DMSO) influences the stability, conformational dynamics and function of proteins/enzymes. We present experimental results obtained from fluorescence correlation spectroscopy on the effect of ionic liquid or alcohol or DMSO on the size (more precisely, the diffusion constant) and conformational dynamics of lysozyme, cytochrome c and human serum albumin in aqueous solution. The interaction of ionic liquid with biomolecules (e...
November 16, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/29147823/primary-peri-implant-oral-intra-epithelial-neoplasia-carcinoma-in-situ-a-case-report-considering-risk-factors-for-carcinogenesis
#15
Makoto Noguchi, Hiroaki Tsuno, Risa Ishizaka, Kumiko Fujiwara, Shuichi Imaue, Kei Tomihara, Takashi Minamisaka
BACKGROUND: Major risk factors for oral squamous cell carcinoma (SCC) are tobacco smoking, a betel quid chewing habit, and heavy alcohol consumption. However, around 15% of oral SCCs cannot be explained by these risk factors. Although oral SCC associated with dental implants is quite rare, there has been a recent gradual accumulation of reports about it. Here, we report a case of primary peri-implant oral intra-epithelial neoplasia/carcinoma in situ (OIN/CIS) in a woman without the major risk factors for oral SCC...
November 16, 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/29147696/a-biocatalytic-cascade-for-the-amination-of-unfunctionalised-cycloalkanes
#16
Michele Tavanti, Juan Mangas-Sanchez, Sarah L Montgomery, Matthew P Thompson, Nicholas J Turner
Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes. Amine product concentrations of up to 19.6 mM were achieved. The preparative scale amination of cyclohexane was also demonstrated with a space-time yield of 2 g L(-1) d(-1).
November 17, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29147540/catalyst-controlled-polycondensation-of-glycerol-with-diacyl-chlorides-linear-polyesters-from-a-trifunctional-monomer
#17
Ekaterina Slavko, Mark S Taylor
Diarylborinic acids catalyze the formation of linear polyesters from glycerol, a trifunctional, carbohydrate-based monomer. The selective activation of 1,2-diols over isolated alcohols by the organoboron catalyst results in polymers that are essentially free of branching or cross-linking and possess a high fraction of 1,3-enchained glycerol units, as assessed by (1)H and (13)C NMR spectroscopy. The ability to generate well-defined polyester architectures from glycerol is significant in light of the numerous applications of such macromolecules, particularly in the biomedical area...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29147516/a-new-route-to-n-aromatic-heterocycles-from-the-hydrogenation-of-diesters-in-the-presence-of-anilines
#18
Yiping Shi, Paul C J Kamer, David J Cole-Hamilton, Michelle Harvie, Emma F Baxter, Kate J C Lim, Peter Pogorzelec
The hydrogenation of dicarboxylic acids and their esters in the presence of anilines provides a new synthesis of heterocycles. [Ru(acac)3] and 1,1,1-tris(diphenylphosphinomethyl)ethane (triphos) gave good to excellent yields of the cyclic amines at 220 °C. When aqueous ammonia was used with dimethyl 1,6-hexadienoic acid, ε-caprolactam was obtained in good yield. A side reaction involving alkylation of the amine by methanol was suppressed by using diesters derived from longer chain and branched alcohols. Hydrogenation of optically pure diesters (dimethyl (R)-2-methylbutanedioate and dimethyl (S)-2-methylbutanedioate) with aniline afforded racemic 3-methyl-1-phenylpyrrolidine in 78% yield...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29147514/%C3%AE-perfluoroalkyl-%C3%AE-alkynylation-of-alkenes-via-radical-alkynyl-migration
#19
Xinjun Tang, Armido Studer
Transition metal-free radical α-perfluoroalkylation with concomitant β-alkynylation of unactivated alkenes is presented. These cascades proceed via electron-catalysis and comprise a radical 1,4- or 1,5-alkynyl migration from tertiary propargylic alcoholates to secondary or tertiary C-radicals as the key step. Alkynyl migration leads to a ketyl radical anion that sustains the chain as a single electron transfer reducing reagent.
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29147063/nativity-race-ethnicity-and-dual-diagnosis-among-us-adults
#20
Magdalena Szaflarski, Shawn Bauldry, Lisa A Cubbins, Karthikeyan Meganathan
Purpose: This study investigated disparities in dual diagnosis (comorbid substance-use and depressive/anxiety disorders) among US adults by nativity and racial-ethnic origin and socioeconomic, cultural, and psychosocial factors that may account for the observed disparities. Design/methodology: The study drew on data from two waves of the National Epidemiological Survey on Alcohol and Related Conditions. Racial-ethnic categories included African, Asian/Pacific Islander, European, Mexican, Puerto Rican, and other Hispanic/Latino...
2017: Research in the Sociology of Health Care
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