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REVIEW
Leila Niemela, Gillian Lamoury, Susan Carroll, Marita Morgia, Albert Yeung, Byeongsang Oh
BACKGROUND: Major depressive disorder (MDD) exhibits gender disparities, and emerging evidence suggests the involvement of the gut microbiome, necessitating exploration of sex-specific differences. METHODS: A review was conducted, encompassing a thorough examination of relevant studies available in Medline via Ovid, Embase via OvidSP, CINAHL, and PsycINFO databases from their inception to June 2023. The search strategy employed specific keywords and Medical Subject Headings (MeSH) terms tailored to major depressive disorder in women, encompassing unipolar depression, depressive symptoms, and dysbiosis...
2024: Frontiers in Psychiatry
#22
JOURNAL ARTICLE
Erin K Moran, Madelyn Shapiro, Adam J Culbreth, Subigya Nepal, Dror Ben-Zeev, Andrew Campbell, Deanna M Barch
BACKGROUND AND HYPOTHESIS: Loneliness, the subjective experience of feeling alone, is associated with physical and psychological impairments. While there is an extensive literature linking loneliness to psychopathology, limited work has examined loneliness in daily life in those with serious mental illness. We hypothesized that trait and momentary loneliness would be transdiagnostic and relate to symptoms and measures of daily functioning. STUDY DESIGN: The current study utilized ecological momentary assessment and passive sensing to examine loneliness in those with schizophrenia (N = 59), bipolar disorder (N = 61), unipolar depression (N = 60), remitted unipolar depression (N = 51), and nonclinical comparisons (N = 82) to examine relationships of both trait and momentary loneliness to symptoms and social functioning in daily life...
March 1, 2024: Schizophrenia Bulletin
#23
JOURNAL ARTICLE
Elizabeth A Gordineer, Dobrivoje S Stokic, Matthias J Krenn
Transcutaneous spinal stimulation (TSS) studies rely on the depolarization of afferent fibers to provide input to the spinal cord; however, this has not been routinely ascertained. Thus, we aimed to characterize the types of responses evoked by TSS and establish paired-pulse ratio cutoffs that distinguish posterior root reflexes, evoked by stimulation of afferent nerve fibers, from motor responses, evoked by stimulation of efferent nerve fibers. Twelve neurologically intact participants (six women) underwent unipolar TSS (cathode over T11-12 spinal processes, anode paraumbilically) while resting supine...
February 28, 2024: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
#24
Identifying genetic differences between bipolar disorder and major depression through multiple GWAS.
Georgia Panagiotaropoulou, Kajsa-Lotta Georgii Hellberg, Jonathan R I Coleman, Darsol Seok, Janos Kalman, Philip B Mitchell, Peter R Schofield, Andreas J Forstner, Michael Bauer, Laura J Scott, Carlos N Pato, Michele T Pato, Qingqin S Li, George Kirov, Mikael Landén, Lina Jonsson, Bertram Müller-Myhsok, Jordan W Smoller, Elisabeth B Binder, Tanja M Brückl, Darina Czamara, Sandra Van der Auwera, Hans J Grabe, Georg Homuth, Carsten O Schmidt, James B Potash, Raymond J DePaulo, Fernando S Goes, Dean F MacKinnon, Francis M Mondimore, Myrna M Weissman, Jianxin Shi, Mark A Frye, Joanna M Biernacka, Andreas Reif, Stephanie H Witt, René R Kahn, Marco M Boks, Michael J Owen, Katherine Gordon-Smith, Brittany L Mitchell, Nicholas G Martin, Sarah E Medland, Lisa Jones, James A Knowles, Douglas F Levinson, Michael C O'Donovan, Cathryn M Lewis, Gerome Breen, Thomas Werge, Andrew J Schork, Roel Ophoff, Stephan Ripke, Loes Olde Loohuis
BACKGROUND: Accurate diagnosis of bipolar disorder (BD) is difficult in clinical practice, with an average delay between symptom onset and diagnosis of about 7 years. A key reason is that the first manic episode is often preceded by a depressive one, making it difficult to distinguish BD from unipolar major depressive disorder (MDD). AIMS: Here, we use genome-wide association analyses (GWAS) to identify differential genetic factors and to develop predictors based on polygenic risk scores that may aid early differential diagnosis...
January 30, 2024: medRxiv
#25
JOURNAL ARTICLE
Cora Schefft, Rico Krämer, Raoul Haaf, David Jedeck, Anna Schumacher, Stephan Köhler
PURPOSE: Depressive disorders cause a major burden of disease worldwide and often lead to a loss of social functioning. Patients suffering from depressive disorders report a lower quality of life (QOL) than people without a history of mental health issues. Internet-based interventions (IBIs) based on cognitive behavioral therapy (CBT) are effective in reducing symptom severity but data on their impact on quality of life in clinically depressed patients so far is scarce. METHODS: Selfapy is a CBT-based IBI for depressive disorders...
February 25, 2024: Quality of Life Research
#26
JOURNAL ARTICLE
Jian Zhang, Rongyi Sun, Yang Cai, Bo Peng, Xi Yang, Keming Gao
BACKGROUND: This meta-analysis aimed to determine the efficacy and safety of antidiabetic agents in the treatment of major depressive disorder and bipolar depression. METHODS: Randomized controlled trials (RCTs) of antidiabetic agents in major depressive disorder or bipolar depression were searched in three electronic databases and three clinical trial registry websites from their inception up to October 2023. The differences in changes in the depression rating scale scores from baseline to endpoint or pre-defined sessions, response rate, remission rate, rate of side effects and dropout rate between antidiabetic agents and placebo were meta-analyzed...
February 19, 2024: Journal of Clinical Medicine
#27
JOURNAL ARTICLE
Víctor Navarro, Joana Guarch, Ilham Boulahfa, Laia Tardón, Amadeu Obach, Cristóbal Gastó, Manel Vila-Vidal
The effect of light or moderate alcohol intake on the outcome of patients with major depression taking antidepressants is a question that remains unanswered. The main objective of this study was to assess the association between light or moderate alcohol consumption and the acute response (efficacy and tolerability) to pharmacological treatment in unipolar major depression. Efficacy and tolerability analyses compared 8-week outcomes between three subgroups, abstainers, light drinkers and moderate drinkers, of patients with major depression using a prospective naturalistic single-blind design...
February 22, 2024: International Clinical Psychopharmacology
#28
JOURNAL ARTICLE
Ying Chen, John C Markowitz, Carlos Blanco, Dawn L Hershman, Joy T Zhang, David J Hellerstein
PURPOSE: Depression is among the most common comorbid psychiatric disorders of patients with breast cancer. Depression decreases patient quality of life and, if untreated, can adversely affect cancer treatment. We sought to identify treatment barriers for women with breast cancer receiving psychotherapy for depression. Findings may help policy makers and researchers determine funding and design of future studies involving this population, especially in communities with high rates of health disparities...
February 20, 2024: Breast Cancer Research and Treatment
#29
JOURNAL ARTICLE
Sara Poletti, Raffaella Zanardi, Alessandra Mandelli, Veronica Aggio, Annamaria Finardi, Cristina Lorenzi, Giovanna Borsellino, Matteo Carminati, Elena Manfredi, Enrico Tomasi, Sara Spadini, Cristina Colombo, Hemmo A Drexhage, Roberto Furlan, Francesco Benedetti
Immune-inflammatory mechanisms are promising targets for antidepressant pharmacology. Immune cell abnormalities have been reported in mood disorders showing a partial T cell defect. Following this line of reasoning we defined an antidepressant potentiation treatment with add-on low-dose interleukin 2 (IL-2). IL-2 is a T-cell growth factor which has proven anti-inflammatory efficacy in autoimmune conditions, increasing thymic production of naïve CD4 + T cells, and possibly correcting the partial T cell defect observed in mood disorders...
February 15, 2024: Brain, Behavior, and Immunity
#30
Alessandro Rodolico, Pierfelice Cutrufelli, Antonio Di Francesco, Andrea Aguglia, Gaetano Catania, Carmen Concerto, Alessandro Cuomo, Andrea Fagiolini, Giuseppe Lanza, Ludovico Mineo, Antimo Natale, Laura Rapisarda, Antonino Petralia, Maria Salvina Signorelli, Eugenio Aguglia
BACKGROUND: Unipolar and bipolar depression present treatment challenges, with patients sometimes showing limited or no response to standard medications. Ketamine and its enantiomer, esketamine, offer promising alternative treatments that can quickly relieve suicidal thoughts. This Overview of Reviews (OoR) analyzed and synthesized systematic reviews (SRs) with meta-analysis on randomized clinical trials (RCTs) involving ketamine in various formulations (intravenous, intramuscular, intranasal, subcutaneous) for patients with unipolar or bipolar depression...
2024: Frontiers in Psychiatry
#31
JOURNAL ARTICLE
Vanessa Gray, William Moot, Christopher M A Frampton, Katie M Douglas, Peter Gallagher, Jennifer Jordan, Janet D Carter, Maree Inder, Marie Crowe, Virginia V W McIntosh, Richard J Porter
INTRODUCTION: Emotion processing is an essential part of interpersonal relationships and social interactions. Changes in emotion processing have been found in both mood disorders and in aging, however, the interaction between such factors has yet to be examined in detail. This is of interest due to the contrary nature of the changes observed in existing research - a negativity bias in mood disorders versus a positivity effect with aging. It is also unclear how changes in non-emotional cognitive function with aging and in mood disorders, interact with these biases...
2024: Frontiers in Psychology
#32
REVIEW
Tommaso Toffanin, Giulia Cattarinussi, Niccolò Ghiotto, Marialaura Lussignoli, Chiara Pavan, Luca Pieri, Sami Schiff, Francesco Finatti, Francesca Romagnolo, Federica Folesani, Maria Giulia Nanni, Rosangela Caruso, Luigi Zerbinati, Martino Belvederi Murri, Maria Ferrara, Giorgio Pigato, Luigi Grassi, Fabio Sambataro
OBJECTIVE: Electroconvulsive therapy (ECT) is one of the most studied and validated available treatments for severe or treatment-resistant depression. However, little is known about the neural mechanisms underlying ECT. This systematic review aims to critically review all structural magnetic resonance imaging studies investigating longitudinal cortical thickness (CT) changes after ECT in patients with unipolar or bipolar depression. METHODS: We performed a search on PubMed, Medline, and Embase to identify all available studies published before April 20, 2023...
February 12, 2024: Acta Neuropsychiatrica
#33
REVIEW
Claudia Savia Guerrera, Francesco Maria Boccaccio, Simone Varrasi, Giuseppe Alessio Platania, Marinella Coco, Concetta Pirrone, Sabrina Castellano, Filippo Caraci, Raffaele Ferri, Giuseppe Lanza
Sleep disorders have become increasingly prevalent, with many adults worldwide reporting sleep dissatisfaction. Major Depressive Disorder (MDD) and Bipolar Disorder (BD) are common conditions associated with disrupted sleep patterns such as insomnia and hypersomnolence. These sleep disorders significantly affect the progression, severity, treatment, and outcome of unipolar and bipolar depression. While there is evidence of a connection between sleep disorders and depression, it remains unclear if sleep features differ between MDD and BD...
February 6, 2024: Neuroscience and Biobehavioral Reviews
#34
JOURNAL ARTICLE
Clotilde Guidetti, Giulia Serra, Massimo Apicella, Elisa Andracchio, Maria Elena Iannoni, Monia Trasolini, Giorgia Della Santa, Gino Maglio, Stefano Vicari
OBJECTIVE: To identify childhood psychopathological features that predict the onset of adolescent Bipolar (BD) versus Unipolar Major Depressive Disorder (UD) during adolescence. METHOD: We analyzed clinical data from 495 juveniles diagnosed with DSM-5 UD ( n = 359), and BD ( n = 136), using bivariate analysis and multivariate logistic regression model. RESULTS: BD subjects exhibited earlier onset of any psychiatric feature compared to UD...
March 2024: Journal of Attention Disorders
#35
REVIEW
Rakesh Kumar, Nicolas A Nuñez, Neha Joshi, Boney Joseph, Alessandra Verde, Ashok Seshadri, Alfredo B Cuellar Barboza, Larry J Prokop, Gustavo C Medeiros, Balwinder Singh
BACKGROUND: Ketamine is increasingly used for treatment-resistant depression (TRD) while its mechanism of action is still being investigated. In this systematic review, we appraise the current evidence of metabolomic biomarkers for racemic ketamine and esketamine in patients with TRD and healthy controls (HCs). METHODS: A comprehensive search of several databases (Ovid MEDLINE®, Embase, and Epub Ahead of Print) was performed from each database's inception to June 29, 2022, in any language, was conducted...
February 7, 2024: Bipolar Disorders
#36
JOURNAL ARTICLE
Maria Faurholt-Jepsen, Darius Adam Rohani, Jonas Busk, Morten Lindberg Tønning, Mads Frost, Jakob Eyvind Bardram, Lars Vedel Kessing
The aims were to investigate 1) differences in smartphone-based data on phone usage between bipolar disorder (BD) and unipolar disorder (UD) and 2) by using machine learning models, the sensitivity, specificity, and AUC of the combined smartphone data in classifying BD and UD. Daily smartphone-based self-assessments of mood and same-time passively collected smartphone data on smartphone usage was available for six months. A total of 64 patients with BD and 74 patients with UD were included. Patients with BD during euthymic states compared with UD in euthymic states had a lower number of incoming phone calls/ day (B: -0...
February 3, 2024: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
#37
JOURNAL ARTICLE
Suvi Virtanen, Mikael Landén, Zheng Chang
No abstract text is available yet for this article.
April 1, 2024: JAMA Psychiatry
#38
JOURNAL ARTICLE
Adrian E Desai Boström, Peter Andersson, Johan Lundberg
No abstract text is available yet for this article.
January 31, 2024: JAMA Psychiatry
#39
JOURNAL ARTICLE
Xiaofeng Lan, Haiyan Liu, Chengyu Wang, Weicheng Li, Fan Zhang, Zhibo Hu, Xiaoyu Chen, Zerui You, Yuping Ning, Yanling Zhou
BACKGROUND: Patients with depression, especially women, are associated with low bone mineral density (BMD). Traditional antidepressants are associated with negative effects on BMD. Few studies have examined the effect of ketamine on BMD, and it remains unclear whether there are sex differences in the effects of ketamine on BMD in patients with depression. METHODS: A total of 102 patients with unipolar and bipolar depression were administered six infusions of intravenous ketamine over a 12-day period...
January 29, 2024: Biology of Sex Differences
#40
JOURNAL ARTICLE
Yi Xia, Xiaoqin Wang, Junling Sheng, Lingling Hua, Zhongpeng Dai, Hao Sun, Yinglin Han, Zhijian Yao, Qing Lu
BACKGROUND: Response inhibition is a key neurocognitive factor contributing to impulsivity in mood disorders. Here, we explored the common and differential alterations of neural circuits associated with response inhibition in bipolar disorder (BD) and unipolar disorder (UD) and whether the oscillatory signatures can be used as early biomarkers in BD. METHODS: 39 patients with BD, 36 patients with UD, 29 patients initially diagnosed with UD who later underwent diagnostic conversion to BD, and 36 healthy controls performed a Go/No-Go task during MEG scanning...
January 23, 2024: Journal of Affective Disorders
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