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https://www.readbyqxmd.com/read/29214818/colorectal-cancer-screening-completion-among-individuals-with-and-without-mental-illnesses-a-comparison-of-2-screening-methods
#1
Bobbi Jo H Yarborough, Ginger C Hanson, Nancy A Perrin, Scott P Stumbo, Carla A Green
PURPOSE: Cancer mortality is worse among people with psychiatric disorders. The purpose of this study was to compare facilitators and rates of colorectal cancer (CRC) screening between people with and without mental illnesses. DESIGN: We conducted a secondary analysis using data from a general population cohort study (N = 92 445) that assessed effects of 2 types of CRC screening test kits-guaiac fecal occult blood testing (gFOBT) and fecal immunochemical testing (FIT)-on CRC screening completion...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29200575/are-we-overdiagnosing-bipolar-disorder
#2
M S Reddy, Starlin M Vijay, Swetha Reddy
Bipolar disorder (BD) is an established diagnostic entity used by clinicians for over a century. It is distinguished by the distinct manic and depressive episodes with interepisode euthymia. It has an illness course where both recovery and recurrences are a rule and has a good long-term prognosis, as reported earlier by Emil Kraeplin. There is an opinion in the current literature that BD is often underdiagnosed as unipolar depression, and based on that opinion, spectrum concept was introduced. Here, we present 5 cases to highlight that overdiagnosis of BD is also not infrequent and we discuss its reasons and therapeutic implications...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29199810/ketamine-as-treatment-for-depression
#3
Tero Taiminen
Ketamine infusions administered intravenously 1 to 3 times per week are the quickest and most effective treatment for depression. Short-course ketamine medication is established treatment both for unipolar depression and depressive episodes of bipolar affective disorder. Ketamine is suitable for initiating the treatment for treatment-resistant depression, alleviation of suicidal tendencies, and treatment of depressive patients suffering from simultaneous pain. The safety of prolonged treatment with ketamine is not known to sufficient degree...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29179142/the-relationship-of-person-specific-eveningness-chronotype-greater-seasonality-and-less-rhythmicity-to-suicidal-behavior-a-literature-review
#4
REVIEW
Meredith E Rumble, Daniel Dickson, W Vaughn McCall, Andrew D Krystal, Doug Case, Peter B Rosenquist, Ruth M Benca
BACKGROUND: Epidemiological data have demonstrated seasonal and circadian patterns of suicidal deaths. Several reviews and meta-analyses have confirmed the relationship between sleep disturbance and suicidality. However, these reviews/meta-analyses have not focused on seasonal and circadian dysfunction in relation to suicidality, despite the common presence of this dysfunction in patients with mood disorders. Thus, the current literature review analyzed studies investigating person-specific chronotype, seasonality, and rhythmicity in relation to suicidal thoughts and behaviors...
November 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29178463/psychotic-delusional-depression-and-suicidal-attempts-a-systematic-review-and-meta-analysis
#5
R Gournellis, K Tournikioti, G Touloumi, C Thomadakis, P G Michalopoulou, C Christodoulou, A Papadopoulou, A Douzenis
OBJECTIVE: It still remains unclear whether psychotic features increase the risk of suicidal attempts in major depressive disorder. Thus, we attempted, through a systematic review coupled with a meta-analysis, to elucidate further whether unipolar psychotic depression (PMD) compared to non-PMD presents higher levels of suicidal attempts. METHOD: A systematic search was conducted in PubMed, EMBASE, PsycINFO as well as in various databases of the so-called gray literature for all studies providing data on suicidal attempts in PMD compared to non-PMD, and the results were then subjected to meta-analysis...
November 26, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29174742/predictors-and-outcomes-of-somatization-in-bipolar-i-disorder-a-latent-class-mixture-modeling-approach
#6
Juliet Beni Edgcomb, Berit Kerner
BACKGROUND: Mood disorders are often associated with somatic symptoms. The role of somatic symptoms on disease progression in unipolar depression is substantially better characterized than that role in bipolar disorder. Moreover, the contribution of comorbid anxiety disorders and medical illness is not well understood. METHOD: We investigated 527 patients with bipolar I disorder clustered within 102 families using a latent class approach. Predictors were added stepwise into the model...
November 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29171490/-genetic-and-clinical-predictors-of-treatment-efficacy-in-depressive-disorders
#7
N N Ivanets, M A Kinkulkina, Yu G Tikhonova, T A Izumina, T I Avdeeva, D I Morozov
AIM: To study clinical and genetic characteristics that impact on the efficacy of pharmacotherapy of depressive disorders. MATERIAL AND METHODS: The study included 188 patients with unipolar depressive disorders of different genesis (psychogenic, endogenous and organic). A clinical-psychopathological method and depression psychometric scales were used. Serotonin transporter 5-HTTLPR and STin2 and dopamine transporter 3',-VNTR polymorphisms were determined. RESULTS AND CONCLUSION: The S-allele of the 5-HTTLPR polymorphism is associated with the low efficacy of treatment with selective serotonin reuptake inhibitors...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29164828/attenuated-psychosis-and-basic-self-disturbance-as-risk-factors-for-depression-and-suicidal-ideation-behaviour-in-community-dwelling-adolescents
#8
Dan Koren, Lily Rothschild-Yakar, Liza Lacoua, Anat Brunstein-Klomek, Aya Zelezniak, Josef Parnas, Golan Shahar
BACKGROUND AND AIMS: Adolescents at clinical high risk (CHR) for psychosis, as defined by the presence of attenuated psychosis symptoms (APS), exhibit increased levels of suicidal ideation and behaviour. However, no research thus far has examined the link between basic self-disturbances (SDs), an established marker for CHR, and suicidality/self-harm in this population. The goal of this pilot study was to assess the association between SD, depression and suicidal ideation and behaviour among non-help-seeking adolescents from the community...
November 22, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29161150/cognitive-impairment-in-schizophrenia-and-depression-a-comparison-of-stability-and-course
#9
Peter Neu, Tina Gooren, Ulrike Niebuhr, Peter Schlattmann
Cognitive deficits are clinically relevant features in schizophrenia and depression, yet little comparative data on changes in both disorders is available. This study compares cognitive performance of inpatients with schizophrenia (N = 52) and unipolar major depression (N = 67) during psychiatric treatment, assessing performance twice: after admission to hospital (acute) and prior to discharge (postacute) on average seven weeks later. A group of healthy controls was tested at comparable intervals. Data was analyzed using a multivariate linear model...
November 21, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29159580/low-left-amygdala-volume-is-associated-with-a-longer-duration-of-unipolar-depression
#10
Maxim Zavorotnyy, Rebecca Zöllner, L R Schulte-Güstenberg, L Wulff, S Schöning, U Dannlowski, H Kugel, V Arolt, C Konrad
The amygdala plays a crucial role in the pathogenesis of major depressive disorder (MDD). While robust findings support a negative impact of illness duration on hippocampal volume in MDD, morphometric studies of the amygdala have yielded inhomogeneous results. Considering the methodical problems of automatic segmentation methods, a standardized segmentation protocol with proven inter- and intra-rater reliability was employed using high-resolution magnetic resonance imaging. To identify the effect of MDD on amygdala morphometry, 23 unipolar depressed patients who responded to antidepressant medication and 30 age-matched healthy controls (HC) were enrolled...
November 20, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29158582/the-camp-responsive-element-binding-creb-1-gene-increases-risk-of-major-psychiatric-disorders
#11
X Xiao, C Zhang, M Grigoroiu-Serbanescu, L Wang, L Li, D Zhou, T-F Yuan, C Wang, H Chang, Y Wu, Y Li, D-D Wu, Y-G Yao, M Li
Bipolar disorder (BPD), schizophrenia (SCZ) and unipolar major depressive disorder (MDD) are primary psychiatric disorders sharing substantial genetic risk factors. We previously reported that two single-nucleotide polymorphisms (SNPs) rs2709370 and rs6785 in the cAMP responsive element-binding (CREB)-1 gene (CREB1) were associated with the risk of BPD and abnormal hippocampal function in populations of European ancestry. In the present study, we further expanded our analyses of rs2709370 and rs6785 in multiple BPD, SCZ and MDD data sets, including the published Psychiatric Genomics Consortium (PGC) genome-wide association study, the samples used in our previous CREB1 study, and six additional cohorts (three new BPD samples, two new SCZ samples and one new MDD sample)...
November 21, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29154168/evaluating-an-e-mental-health-program-deprexis-as-adjunctive-treatment-tool-in-psychotherapy-for-depression-results-of-a-pragmatic-randomized-controlled-trial
#12
Thomas Berger, Tobias Krieger, Kerstin Sude, Björn Meyer, Andreas Maercker
BACKGROUND: Depressive disorders place a significant disease burden on individuals as well as on societies. Several web-based interventions for depression have shown to be effective in reducing depressive symptoms. However, it is not known whether web-based interventions, when used as adjunctive treatment tools to regular psychotherapy, have an additional effect compared to regular psychotherapy for depression. METHODS: Adults (N = 98) with a unipolar affective disorder were recruited in routine outpatient psychotherapy practices in Germany from therapists over the course of their initial sessions and randomized within therapists to one of two active treatment conditions: regular psychotherapy or psychotherapy plus a web-based depression program ("deprexis")...
November 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29149717/usefulness-of-the-montreal-cognitive-assessment-moca-to-monitor-cognitive-impairments-in-depressed-patients-receiving-electroconvulsive-therapy
#13
Rémi Moirand, Filipe Galvao, Maxime Lecompte, Emmanuel Poulet, Frédéric Haesebaert, Jerome Brunelin
There is a lack of consensual tools for evaluating the cognitive side-effects in patients with depression who are treated with electroconvulsive therapy (ECT). The objective of this study was to evaluate the usefulness of the Montreal Cognitive Assessment (MoCA) and of the Mini Mental State Examination (MMSE) to monitor cognitive changes in patients with depression receiving ECT. Cognitive functioning was assessed prospectively in 48 patients with unipolar or bipolar depression before and after an ECT course...
November 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29135294/-study-of-socio-demographic-factors-in-the-treatment-of-unipolar-major-depression-in-a-follow-up-clinical-trial
#14
Melinda Ferencz, Sándor Csibi, József Gabos Grecu
INTRODUCTION: Depression is one of the most widespread illnesses of our time, currently affecting more than 300 million people worldwide. Literature identifies several socio-demographic risk factors in the development of the depression. AIM: We aim to examine the socio-demographic factors involved in the remission of clinically diagnosed unipolar major depression. METHOD: Data collection was performed during 2016, at the 1st Psychiatric Clinic from Tirgu Mures...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29132814/incidence-of-child-and-adolescent-mental-disorders-in-children-aged-0-17-with-familial-high-risk-for-severe-mental-illness-a-danish-register-study
#15
Anne A E Thorup, Thomas Munk Laursen, Trine Munk-Olsen, Anne Ranning, Preben Bo Mortensen, Kerstin J Plessen, Merete Nordentoft
BACKGROUND: Offspring of parents with severe mental illness (SMI: schizophrenia, bipolar disorder or major depressive disorder) have an increased risk of developing mental disorder themselves. In childhood they may have neurodevelopmental delays, cognitive deficits and social adversities. We aimed to investigate if these individuals are more at risk of being diagnosed with a mental disorder during childhood/adolescence in a national sample. METHODS: By linking Danish registers we established a cohort consisting of all persons born to parents with SMI with those born to parents without SMI serving as a reference group...
November 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29120845/markers-of-dna-rna-damage-from-oxidation-as-predictors-of-a-registry-based-diagnosis-of-psychiatric-illness-in-type-2-diabetic-patients
#16
Anders Jorgensen, Volkert Siersma, Annette S Davidsen, Allan Weimann, Trine Henriksen, Henrik E Poulsen, Niels de Fine Olivarius
Oxidative stress is a potential biological mediator of the higher rates of psychiatric illness (PI) observed after the onset of type 2 diabetes (T2DM). We investigated validated urinary markers of systemic DNA/RNA damage from oxidation (8-oxodG/8-oxoGuo respectively) as predictors of incident PI in a cohort of 1381 newly diagnosed T2DM patients, who were followed prospectively for a total of 19 years after diagnosis. Psychiatric diagnoses were from Danish national registries. Patients were examined at the time of diagnosis and at a 6-year follow-up...
November 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29119217/psilocybin-with-psychological-support-for-treatment-resistant-depression-six-month-follow-up
#17
R L Carhart-Harris, M Bolstridge, C M J Day, J Rucker, R Watts, D E Erritzoe, M Kaelen, B Giribaldi, M Bloomfield, S Pilling, J A Rickard, B Forbes, A Feilding, D Taylor, H V Curran, D J Nutt
RATIONALE: Recent clinical trials are reporting marked improvements in mental health outcomes with psychedelic drug-assisted psychotherapy. OBJECTIVES: Here, we report on safety and efficacy outcomes for up to 6 months in an open-label trial of psilocybin for treatment-resistant depression. METHODS: Twenty patients (six females) with (mostly) severe, unipolar, treatment-resistant major depression received two oral doses of psilocybin (10 and 25 mg, 7 days apart) in a supportive setting...
November 8, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29111077/international-randomized-controlled-trial-of-transcranial-direct-current-stimulation-in-depression
#18
Colleen K Loo, Mustafa M Husain, William M McDonald, Scott Aaronson, John P O'Reardon, Angelo Alonzo, Cynthia Shannon Weickert, Donel M Martin, Shawn M McClintock, Adith Mohan, Sarah H Lisanby
BACKGROUND: Evidence suggests that transcranial Direct Current Stimulation (tDCS) has antidepressant effects in unipolar depression, but there is limited information for patients with bipolar depression. Additionally, prior research suggests that brain derived neurotrophic factor (BDNF) Val66Met genotype may moderate response to tDCS. OBJECTIVE: To examine tDCS efficacy in unipolar and bipolar depression and assess if BDNF genotype is associated with antidepressant response to tDCS...
October 27, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29107623/early-symptom-improvement-at-10-sessions-as-a-predictor-of-rtms-treatment-outcome-in-major-depression
#19
Kfir Feffer, Hyewon Helen Lee, Farrokh Mansouri, Peter Giacobbe, Fidel Vila-Rodriguez, Sidney H Kennedy, Zafiris J Daskalakis, Daniel M Blumberger, Jonathan Downar
BACKGROUND: Predicting rTMS nonresponse could be helpful in sparing patients from futile treatment, and in improving use of limited rTMS resources. While several predictive biomarkers have been proposed, few are accurate for individual-level prediction; none have entered routine use. An alternative approach in pharmacotherapy predicts outcome from early response; patients showing minimal (e.g., ≤20%) improvement at 2 weeks can be predicted as nonresponders with negative predictive values (NPV) > 80-90%...
October 19, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29102836/efficacy-and-tolerability-of-minocycline-for-depression-a-systematic-review-and-meta-analysis-of-clinical-trials
#20
REVIEW
Joshua D Rosenblat, Roger S McIntyre
BACKGROUND: Minocycline has been identified as a potential novel treatment for depression. The objective of the current review is to determine the overall antidepressant efficacy and tolerability of minocycline. METHODS: Completed and ongoing clinical trials of minocycline for depression (both bipolar and unipolar) published prior to September 12, 2017 were identified through searching relevant databases. Using a random-effects model, data from randomized controlled trials (RCTs) were pooled to determine the antidepressant effect size of minocycline compared to placebo...
October 28, 2017: Journal of Affective Disorders
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