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https://www.readbyqxmd.com/read/29679069/pharmacological-treatment-of-adult-bipolar-disorder
#1
REVIEW
Ross J Baldessarini, Leonardo Tondo, Gustavo H Vázquez
We summarize evidence supporting contemporary pharmacological treatment of phases of BD, including: mania, depression, and long-term recurrences, emphasizing findings from randomized, controlled trials (RCTs). Effective treatment of acute or dysphoric mania is provided by modern antipsychotics, some anticonvulsants (divalproex and carbamazepine), and lithium salts. Treatment of BD-depression remains unsatisfactory but includes some modern antipsychotics (particularly lurasidone, olanzapine + fluoxetine, and quetiapine) and the anticonvulsant lamotrigine; value and safety of antidepressants remain controversial...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29674982/delusional-themes-across-affective-and-non-affective-psychoses
#2
Angelo Picardi, Laura Fonzi, Mauro Pallagrosi, Antonella Gigantesco, Massimo Biondi
The current debate about the diagnostic significance of delusion revolves around two positions. The neurocognitive position conceives delusion as a non-specific, though polymorphic, symptom. The psychopathological position views features of delusion such as content and structure as having meaningful connections with diagnostic entities. This study aims at contributing to this debate by examining the association between delusional themes and diagnosis in a sample of 830 adult psychotic patients. All diagnoses were made by experienced psychiatrists according to DSM-IV or ICD-10 criteria, and in 348 patients were established with the SCID-I...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29673379/erythropoietin-as-an-add-on-treatment-for-cognitive-side-effects-of-electroconvulsive-therapy-a-study-protocol-for-a-randomized-controlled-trial
#3
Lejla Sjanic Schmidt, Jeff Zarp Petersen, Maj Vinberg, Ida Hageman, Niels Vidiendal Olsen, Lars Vedel Kessing, Martin Balslev Jørgensen, Kamilla Woznica Miskowiak
BACKGROUND: Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, but its use is impeded by its cognitive side effects. Novel treatments that can counteract these side effects may therefore improve current treatment strategies for depression. The present randomized trial investigates (1) whether short-term add-on treatment with erythropoietin (EPO) can reduce the cognitive side -effects of ECT and (2) whether such effects are long-lasting. Further, structural and functional magnetic resonance imaging (MRI) will be used to explore the neural underpinnings of such beneficial effects of EPO...
April 19, 2018: Trials
https://www.readbyqxmd.com/read/29667799/shrink-that-frown-botulinum-toxin-therapy-is-lifting-the-face-of-psychiatry
#4
M Axel Wollmer, Insa Neumann, Michelle Magid, Tillmann H Kruger
Treating glabellar frown lines with injections of botulinum toxin is the most frequently applied procedure in aesthetic medicine. In addition to its cosmetic effect, botulinum toxin may also positively modulate mood and affect, which may contribute to its popularity. A series of clinical studies has shown that this modulation can be used in the treatment of major depression. After a single glabellar treatment with botulinum toxin, patients suffering from unipolar depression experienced a quick, strong and sustained improvement in the symptoms of depression...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29649674/are-there-clinical-and-neurophysiologic-predictive-factors-for-a-positive-response-to-hf-rtms-in-patients-with-treatment-resistant-depression
#5
Anna Poleszczyk, Maria Rakowicz, Tadeusz Parnowski, Jakub Antczak, Łukasz Święcicki
Better selection of patients with treatment-resistant depression for high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) would make the procedure more efficient. The objective of this study was to search for clinical and neurophysiologic predictors of therapeutic response with a special focus on the bipolar population. Forty patients (30 bipolar) underwent 20 daily sessions of HF-rTMS. Clinical outcome measures included the 21-item Hamilton Depression Rating Scale, the Beck Depression Inventory, the Clinical Global Impression, and the Patient Global Impression...
April 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29642877/standardisation-framework-for-the-maudsley-staging-method-for-treatment-resistance-in-depression
#6
Abebaw Fekadu, Jacek G Donocik, Anthony J Cleare
BACKGROUND: Treatment-resistant depression (TRD) is a serious and relatively common clinical condition. Lack of consensus on defining and staging TRD remains one of the main barriers to understanding TRD and approaches to intervention. The Maudsley Staging Method (MSM) is the first multidimensional model developed to define and stage treatment-resistance in "unipolar depression". The model is being used increasingly in treatment and epidemiological studies of TRD and has the potential to support consensus...
April 11, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29607445/a-review-on-the-general-stability-of-mood-disorder-diagnoses-along-the-lifetime
#7
REVIEW
Diego de la Vega, Ana Piña, Francisco J Peralta, Sam A Kelly, Lucas Giner
PURPOSE OF REVIEW: The purpose of this review is to review the most recent literature regarding diagnostic stability of mood disorders, focusing on epidemiological, clinical-psychopathological, and neurobiological data for unipolar and bipolar affective disorders. RECENT FINDINGS: Unipolar depression follows a chronic course in at least half of all cases and presents a considerable diagnostic stability across all age ranges. Studies using latent class analysis are allowing improved profiling of depressive subtypes and assessment of their prevalence...
April 2, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29601896/differentiating-between-bipolar-and-unipolar-depression-in-functional-and-structural-mri-studies
#8
REVIEW
Kyu-Man Han, Domenico De Berardis, Michele Fornaro, Yong-Ku Kim
Distinguishing depression in bipolar disorder (BD) from unipolar depression (UD) solely based on clinical clues is difficult, which has led to the exploration of promising neural markers in neuroimaging measures for discriminating between BD depression and UD. In this article, we review structural and functional magnetic resonance imaging (MRI) studies that directly compare UD and BD depression based on neuroimaging modalities including functional MRI studies on regional brain activation or functional connectivity, structural MRI on gray or white matter morphology, and pattern classification analyses using a machine learning approach...
March 27, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29597072/increased-prevalence-of-anxiety-disorders-in-third-generation-migrants-in-comparison-to-natives-and-to-first-generation-migrants
#9
Baptiste Pignon, Ali Amad, Antoine Pelissolo, Thomas Fovet, Pierre Thomas, Guillaume Vaiva, Jean-Luc Roelandt, Imane Benradia, Benjamin Rolland, Pierre A Geoffroy
INTRODUCTION: We sought to examine the prevalence of anxiety disorders associated with migration in the first-, second- and third-generation. METHODS: The French Mental Health in the General Population cross-sectional survey interviewed 38,694 individuals using the MINI. The prevalence of lifetime anxiety disorders, and comorbidities was compared between migrants and non-migrants and by generation. All analyses were adjusted for age, sex, and income and education levels...
March 20, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29580768/functional-connectivity-between-anterior-insula-and-key-nodes-of-frontoparietal-executive-control-and-salience-networks-distinguish-bipolar-depression-from-unipolar-depression-and-healthy-control-subjects
#10
Kristen K Ellard, Jared P Zimmerman, Navneet Kaur, Koene R A Van Dijk, Joshua L Roffman, Andrew A Nierenberg, Darin D Dougherty, Thilo Deckersbach, Joan A Camprodon
BACKGROUND: Patients with bipolar depression are characterized by dysregulation across the full spectrum of mood, differentiating them from patients with unipolar depression. The ability to switch neural resources among the default mode network, salience network, and executive control network (ECN) has been proposed as a key mechanism for adaptive mood regulation. The anterior insula is implicated in the modulation of functional network switching. Differential connectivity between anterior insula and functional networks may provide insights into pathophysiological differences between bipolar and unipolar mood disorders, with implications for diagnosis and treatment...
February 7, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29579109/using-data-linkage-to-electronic-patient-records-to-assess-the-validity-of-selected-mental-health-diagnoses-in-english-hospital-episode-statistics-hes
#11
Katrina Alice Southworth Davis, Oliver Bashford, Amelia Jewell, Hitesh Shetty, Robert J Stewart, Cathie L M Sudlow, Matthew Hugo Hotopf
BACKGROUND: Administrative data can be used to support research, such as in the UK Biobank. Hospital Episode Statistics (HES) are national data for England that include contain ICD-10 diagnoses for inpatient mental healthcare episodes, but the validity of these diagnoses for research purposes has not been assessed. METHODS: 250 peoples' HES records were selected based on a HES recorded inpatient stay at the South London and Maudsley NHS Foundation Trust with a diagnosis of schizophrenia, a wider schizophrenia spectrum disorder, bipolar affective disorder or unipolar depression...
2018: PloS One
https://www.readbyqxmd.com/read/29577229/comparison-of-guidelines-for-the-treatment-of-unipolar-depression-a-focus-on-pharmacotherapy-and-neurostimulation
#12
REVIEW
A J Bayes, G B Parker
OBJECTIVE: To determine the level of agreement across a set of evidence-based guidelines for management of the unipolar depressive disorders and with a focus on physical treatments. METHOD: A literature search was undertaken using the terms 'depression', 'depressive' and 'guidelines', using PubMed, Cochrane Database of Systematic Reviews and the National Guideline Clearinghouse. Twelve national psychiatric or professional guideline-producing organizations were identified from the period 2007-2017, with guidelines qualitatively reviewed by two assessors...
March 25, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29575387/indicators-to-facilitate-the-early-identification-of-patients-with-major-depressive-disorder-in-need-of-highly-specialized-care-a-concept-mapping-study
#13
F C W van Krugten, M Goorden, A J L M van Balkom, J Spijker, W B F Brouwer, L Hakkaart-van Roijen
BACKGROUND: Early identification of the subgroup of patients with major depressive disorder (MDD) in need of highly specialized care could enhance personalized intervention. This, in turn, may reduce the number of treatment steps needed to achieve and sustain an adequate treatment response. The aim of this study was to identify patient-related indicators that could facilitate the early identification of the subgroup of patients with MDD in need of highly specialized care. METHODS: Initial patient indicators were derived from a systematic review...
March 25, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29562903/towards-characterizing-the-regional-cerebral-perfusion-in-evaluating-the-severity-of-major-depression-disorder-with-spect-ct
#14
Jinming Li, Yuan Yang, Yuankai Zhu, Liqiang Zhou, Yunfeng Han, Tao Yin, Zhaoting Cheng, Guopeng Zhang, Yanxia Shen, Jing Chen
BACKGROUND: Major depressive disorder (MDD) is a common mental disorder worldwide, but now there is a lack of clinically effective assessment and management of MDD. In this study, we used technetium-99 m ethylcysteinate dimer ([99m Tc]ECD) SPECT/CT to characterize the regional cerebral blood flow (rCBF) status of MDD patients, and to explore an objective image assessment model of MDD which is non- or minimally-invasive, convenient and accurate in a clinical setting. METHODS: The severity of MDD was assessed by three trained psychiatrists, based on scores obtained from HAMD and HAMA...
March 21, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29548306/psychopathological-and-sociodemographic-features-in-treatment-resistant-unipolar-depression-versus-bipolar-depression-a-comparative-study
#15
Nicolas A Nuñez, Stefano Comai, Eduard Dumitrescu, Maykel F Ghabrash, John Tabaka, Marie Saint-Laurent, Stephen Vida, Theodore Kolivakis, Allan Fielding, Nancy Low, Pablo Cervantes, Linda Booij, Gabriella Gobbi
BACKGROUND: Some authors have hypothesized that Treatment-Resistant Unipolar Depression (TRD-UP) should be considered within the bipolar spectrum disorders and that hidden bipolarity may be a risk factor for TRD-UP. However, there are neither studies comparing clinical and sociodemographic data of patients with TRD-UP versus Bipolar (BP) disorders nor are there any examining differences versus Bipolar type I (BP-I) and Bipolar type II (BP-II). METHODS: Charts analysis was conducted on 194 patients followed at the Mood Disorders Clinic of the McGill University Health Center...
March 16, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29546857/efficacy-and-safety-of-repetitive-transcranial-magnetic-stimulation-using-an-h1-coil-or-figure-8-coil-in-the-treatment-of-unipolar-major-depressive-disorder-a-study-protocol-for-a-randomized-controlled-trial
#16
Igor Filipčić, Ivona Šimunović Filipčić, Tomislav Gajšak, Željko Milovac, Strahimir Sučić, Ena Ivezić, Sandra Zečević Penić, Ivana Orgulan, Damir Šebo, Vjekoslav Jeleč, Žarko Bajić
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique with few side effects that has been reported to be effective in the treatment of major depressive disorder (MDD). At present, no randomized controlled trials (RCT) have compared the efficacy and safety of rTMS delivered by the figure-8-coil and the H1-coil. We describe an industry-independent, randomized, controlled, single-blinded, single-center study protocol assessing the differences in efficacy and safety of rTMS for patients diagnosed with MDD with the H1-coil and figure-8-coil as an add-on to stable pharmacotherapy or pharmacotherapy alone...
March 2018: Psychiatria Danubina
https://www.readbyqxmd.com/read/29544775/a-yinyang-bipolar-fuzzy-cognitive-topsis-method-to-bipolar-disorder-diagnosis
#17
Ying Han, Zhenyu Lu, Zhenguang Du, Qi Luo, Sheng Chen
BACKGROUND AND OBJECTIVE: Bipolar disorder is often mis-diagnosed as unipolar depression in the clinical diagnosis. The main reason is that, different from other diseases, bipolarity is the norm rather than exception in bipolar disorder diagnosis. YinYang bipolar fuzzy set captures bipolarity and has been successfully used to construct a unified inference mathematical modeling method to bipolar disorder clinical diagnosis. Nevertheless, symptoms and their interrelationships are not considered in the existing method, circumventing its ability to describe complexity of bipolar disorder...
May 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29544167/glutamatergic-hypofunction-in-medication-free-major-depression-secondary-effects-of-affective-diagnosis-and-relationship-to-peripheral-glutaminase
#18
Toby Wise, Matthew J Taylor, Andres Herane-Vives, Antonella Marino Gammazza, Francesco Cappello, David J Lythgoe, Steve Cr Williams, Allan H Young, Anthony J Cleare, Danilo Arnone
BACKGROUND: There is uncertainty as to whether alterations in glutamatergic function in affective disorders differ between unipolar and bipolar disorders and between depressive and euthymic states. Additionally, there are currently no available blood-based markers of central glutamatergic function to support clinical diagnosis and aid brain based investigations. METHODS: In this study, we measured levels of glutamate in the dorsal anterior cingulate cortex in-vivo using 1H-Magnetic Resonance Spectroscopy in medication free unipolar and bipolar patients (n = 29, 20 unipolar and 9 bipolar) experiencing a major depressive episode, in comparison with a group of matched healthy controls (n = 20)...
February 27, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29540250/incidence-of-unipolar-and-bipolar-depression-and-mania-in-adults-with-intellectual-disabilities-prospective-cohort-study
#19
Sally-Ann Cooper, Elita Smiley, Linda Allan, Jillian Morrison
BACKGROUND: Incidence and determinants of affective disorders among adults with intellectual disabilities are unknown. Aims To investigate affective disorder incidence, and determinants of unipolar depression, compared with general population reports. METHOD: Prospective cohort study measuring mental ill health of adults with mild to profound intellectual disabilities living within a defined community, over 2 years. RESULTS: There was 70% cohort retention (n = 651)...
March 15, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29534632/prevalence-and-risk-of-violent-ideation-and-behavior-in-serious-mental-illnesses-an-analysis-of-63-572-patient-records
#20
Matthew W Roché, Douglas J Boyle, Chia-Cherng Cheng, Jill Del Pozzo, Lindsay Cherneski, Joe Pascarella, Alicia Lukachko, Steven M Silverstein
Research has consistently demonstrated that people diagnosed with serious mental illness (SMI) are at increased risk for violent ideation and behavior (VIB) and that this is especially the case for SMI patients with comorbid substance use disorders (SUD). Despite this, what is still largely unknown is the relative prevalence of VIB across diagnostic categories, whether the rates of VIB in SMI groups exceed the rates observed in people with SUD only, and which demographic factors increase the likelihood of VIB under different circumstances for people with SMI...
March 1, 2018: Journal of Interpersonal Violence
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