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Unipolar depression

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https://www.readbyqxmd.com/read/29466722/shared-and-distinct-regional-homogeneity-changes-in-bipolar-and-unipolar-depression
#1
Xudong Yao, Zhiyang Yin, Fang Liu, Shengnan Wei, Yifang Zhou, Xiaowei Jiang, Yange Wei, Ke Xu, Fei Wang, Yanqing Tang
BACKGROUND: Bipolar depression (BD) is easily misdiagnosed as unipolar depression (UD) or major depressive disorder (MDD) because the depressive symptoms can overlap. Regional homogeneity (ReHo), a measure commonly used for analyzing resting-state fMRI data, has been applied to the study of various neuropsychiatric disorders. However, to date, studies directly comparing BD and UD using ReHo have been relatively scarce. Further investigation is needed to study the latent pathophysiological mechanisms of BD and UD...
February 18, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29442609/caveat-emptor-folate-in-unipolar-depressive-illness-a-systematic-review-and-meta-analysis
#2
Emmert Roberts, Ben Carter, Allan H Young
BACKGROUND: International guideline recommendations for the use of folate and its derivatives in the treatment of unipolar depressive disorders are confused and contradictory, perhaps reflecting wide variations in the underpinning evidence base. INTRODUCTION: We discuss differing methods of evidence synthesis in the formulation of international guideline recommendations. As an example we evaluated the efficacy of folate and its derivatives in unipolar depression via systematic review and meta-analysis...
February 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29415552/eveningness-is-associated-with-poor-sleep-quality-and-negative-affect-in-obsessive-compulsive-disorder
#3
Péter Simor, András Harsányi, Kata Csigó, Gergely Miklós, Alpár Sándor Lázár, Gyula Demeter
Background Obsessive-compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive behaviors that severely encumber daily functioning. OCD patients seem to exhibit sleep disturbances, especially delayed bedtimes that reflect disrupted circadian rhythmicity. Morningness-eveningness is a fundamental factor reflecting individual variations in diurnal preferences related to sleep and waking activities. Eveningness reflecting a delayed sleep-wake timing has repeatedly been associated with sleep problems and negative affect (NA)...
February 8, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29414386/electroconvulsive-therapy-among-elderly-patients-a-study-from-tertiary-care-centre-in-north-india
#4
Sandeep Grover, Ashirbad Satapathy, Subho Chakrabarti, Ajit Avasthi
OBJECTIVE: This retrospective study aimed to evaluate the effectiveness and safety of ECT among elderly patients receiving electroconvulsive therapy (ECT). METHODS: During the study period of January 2008 to May 2017, 151 patients aged ≥60 years received ECT and they formed the study sample. Data on patients aged 19 to 59 years for the period of 3 years (2014-2016) was also extracted for comparison purposes. RESULTS: The mean age of the elderly subjects was 65...
January 31, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29404648/-psychotherapy-of-depressive-disorders-evidence-in-chronic-depression-and-comorbidities
#5
REVIEW
M Härter, A Jansen, M Berger, H Baumeister, T Bschor, T Harfst, M Hautzinger, L Kriston, C Kühner, H Schauenburg, S G Schorr, F Schneider, R Meister
BACKGROUND: Psychotherapy has been shown to be an effective treatment option for depressive disorders; however, its effectiveness varies depending on patient and therapist characteristics and the individual form of the depressive disorder. OBJECTIVES: The aim of this article is to present the current evidence for psychotherapeutic antidepressive treatments for patients with chronic and treatment-resistant depression as well as for patients with mental and somatic comorbidities...
February 5, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29398354/a-machine-learning-approach-to-identifying-placebo-responders-in-late-life-depression-trials
#6
Sigal Zilcha-Mano, Steven P Roose, Patrick J Brown, Bret R Rutherford
OBJECTIVE: Despite efforts to identify characteristics associated with medication-placebo differences in antidepressant trials, few consistent findings have emerged to guide participant selection in drug development settings and differential therapeutics in clinical practice. Limitations in the methodologies used, particularly searching for a single moderator while treating all other variables as noise, may partially explain the failure to generate consistent results. The present study tested whether interactions between pretreatment patient characteristics, rather than a single-variable solution, may better predict who is most likely to benefit from placebo versus medication...
January 11, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29394251/examining-the-short-term-anxiolytic-and-antidepressant-effect-of-floatation-rest
#7
Justin S Feinstein, Sahib S Khalsa, Hung-Wen Yeh, Colleen Wohlrab, W Kyle Simmons, Murray B Stein, Martin P Paulus
Floatation-REST (Reduced Environmental Stimulation Therapy) reduces sensory input to the nervous system through the act of floating supine in a pool of water saturated with Epsom salt. The float experience is calibrated so that sensory signals from visual, auditory, olfactory, gustatory, thermal, tactile, vestibular, gravitational and proprioceptive channels are minimized, as is most movement and speech. This open-label study aimed to examine whether Floatation-REST would attenuate symptoms of anxiety, stress, and depression in a clinical sample...
2018: PloS One
https://www.readbyqxmd.com/read/29387876/mortality-rates-after-the-first-diagnosis-of-psychotic-disorder-in-adolescents-and-young-adults
#8
Gregory E Simon, Christine Stewart, Bobbi Jo Yarborough, Frances Lynch, Karen J Coleman, Arne Beck, Belinda H Operskalski, Robert B Penfold, Enid M Hunkeler
Importance: Individuals with psychotic disorders have increased mortality, and recent research suggests a marked increase shortly after diagnosis. Objective: To use population-based data to examine overall and cause-specific mortality after first diagnosis of a psychotic disorder. Design, Setting, and Participants: This cohort study used records from 5 integrated health systems that serve more than 8 million members in 5 states. Members aged 16 through 30 years who received a first lifetime diagnosis of a psychotic disorder from September 30, 2009, through September 30, 2015, and 2 comparison groups matched for age, sex, health system, and year of diagnosis were selected from all members making an outpatient visit (general outpatient group) and from all receiving a first diagnosis of unipolar depression (unipolar depression group)...
January 31, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29383414/-psychotherapy-of-depressive-disorders-procedures-evidence-and-perspectives
#9
REVIEW
R Meister, A Jansen, M Berger, H Baumeister, T Bschor, T Harfst, M Hautzinger, L Kriston, C Kühner, H Schauenburg, S G Schorr, F Schneider, M Härter
BACKGROUND: Depressive disorders are associated with a high burden of suffering and significantly reduce the well-being and the self-esteem of affected patients. Psychotherapy is one of the main treatment options for depressive disorders. OBJECTIVE: The aim of this article is to present the current evidence for antidepressive psychotherapeutic treatments. MATERIAL AND METHODS: During the revision of the German S3- and National Disease Management Guideline (NDMG) on unipolar depression in 2015, a comprehensive and systematic evidence search was conducted...
January 30, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29382902/cognitive-impairment-in-treatment-na%C3%A3-ve-bipolar-ii-and-unipolar-depression
#10
Arthur D P Mak, Domily T Y Lau, Alicia K W Chan, Suzanne H W So, Owen Leung, Sheila L Y Wong, Linda Lam, C M Leung, Sing Lee
Cognition dysfunction may reflect trait characteristics of bipolarity but cognitive effects of medications have confounded previous comparisons of cognitive function between bipolar II and unipolar depression, which are distinct clinical disorders with some overlaps. Therefore, we examined the executive function (WCST), attention, cognitive speed (TMT-A) and memory (CAVLT, WMS-Visual reproduction) of 20 treatment-naïve bipolar II patients (BPII), 35 treatment-naïve unipolar depressed (UD) patients, and 35 age/sex/education matched healthy controls...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29374473/epidemiology-of-gastrointestinal-symptoms-in-young-and-middle-aged-swiss-adults-prevalences-and-comorbidities-in-a-longitudinal-population-cohort-over-28%C3%A2-years
#11
Maria Avramidou, Felix Angst, Jules Angst, André Aeschlimann, Wulf Rössler, Ulrich Schnyder
BACKGROUND: Although subacute and chronic gastrointestinal symptoms are very common in primary care, epidemiological date are sparse. The aim of the study was to examine and quantify the prevalence of subacute and chronic gastrointestinal symptoms and their associations with somatic and mental disorders in the general population. METHODS: Data were collected prospectively between 1981 (age m = 22, f = 23) and 2008 (age 49/50) from the Zurich Cohort Study (n = 292 men, 299 women), a representative general population survey...
January 27, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29373619/a-brief-history-of-polarity-in-mood-and-its-diagnostic-evolution
#12
Omar Khan, Nagy A Youssef
BACKGROUND: We reviewed the historical development of diagnostic nomenclature and classification systems of mood disorders. METHODS: A literature search in PubMed and Google Scholar was performed using multiple search terms. Also, the criteria and classification of various mood disorders were reviewed and compared across all editions of DSM. We also reviewed several books and the references of the found articles. RESULTS: This review describes the historical development of the concepts and diagnostic nomenclature of mood disorders, including the encompassing of most of the now major depressive disorder under the prior manic-depressive illness...
February 2018: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/29369215/association-between-daily-life-experience-and-psychological-well-being-in-people-living-with-nonpsychotic-mental-disorders-protocol-for-a-systematic-review-and-meta-analysis
#13
REVIEW
Jeffery Ho, Shirley P C Ngai, William K K Wu, Wai Kai Hou
BACKGROUND: Evidence has shown that people living with nonpsychotic mental disorders experience difficulties in maintaining their daily living, consequently impacting on psychological well-being. However, the role of daily life experience remains unclear. This systematic review and meta-analysis aims to determine the association between daily life experience and psychological well-being in people living with nonpsychotic mental disorders, and evaluate daily life experience as a moderator of psychological well-being in this population...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29367224/the-effect-of-a-therapeutic-lithium-level-on-a-stroke-related-cerebellar-tremor
#14
Rachel A Orleans, Marc J Dubin, Kristopher A Kast
Lithium is a mood stabiliser used in the treatment of acute mania, bipolar disorder and as augmentation for unipolar major depression. Tremor is a common adverse effect associated with lithium at both therapeutic and toxic serum levels. We present a case of dose-dependent changes in the quality and intensity of a stroke-related, chronic cerebellar tremor with lithium treatment at serum levels within the therapeutic range. On admission, the patient in this case had a baseline fine, postural tremor, which increased in frequency and evolved to include myoclonic jerks once lithium therapy was initiated...
January 24, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29367060/hippocampal-shape-alterations-in-healthy-young-women-with-familial-risk-for-unipolar-depression
#15
Ece Durmusoglu, Onur Ugurlu, Sebnem Akan, Fatma Simsek, Gozde Kizilates, Omer Kitis, Burcu Aksoy Ozkul, Cagdas Eker, Kerry L Coburn, Ali Saffet Gonul
BACKGROUND: Although reduced hippocampal volume (HCV) is a common finding in depression, it is unclear whether the structural alterations leading to reduction of HCV are pre-existing risk factors before the onset of clinical symptoms or a cumulative process that begins with the onset of clinical symptoms. The aim of the present study was to understand the anatomical status of the hippocampus prior to the clinical symptoms in subjects with high familial risk for depression. METHODS: Twenty-seven young women (mean age: 22...
January 9, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29361848/care-pathways-before-first-diagnosis-of-a-psychotic-disorder-in-adolescents-and-young-adults
#16
Gregory E Simon, Christine Stewart, Enid M Hunkeler, Bobbi Jo Yarborough, Frances Lynch, Karen J Coleman, Arne Beck, Belinda H Operskalski, Robert B Penfold, David S Carrell
OBJECTIVE: The authors sought to describe patterns of health care use prior to first diagnosis of a psychotic disorder in a population-based sample. METHOD: Electronic health records and insurance claims from five large integrated health systems were used to identify 624 patients 15-29 years old who received a first diagnosis of a psychotic disorder in any care setting and to record health services received, diagnoses assigned, and medications dispensed during the previous 36 months...
January 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29360577/test-retest-reliability-of-the-diagnosis-of-schizoaffective-disorder-in-childhood-and-adolescence-a-systematic-review-and-meta-analysis
#17
Sarah Salamon, Hanno Santelmann, Jeremy Franklin, Christopher Baethge
OBJECTIVES: Reliability of schizoaffective disorder (SAD) diagnoses is low in adults but unclear in children and adolescents (CAD). We estimate the test-retest reliability of SAD and its key differential diagnoses (schizophrenia, bipolar disorder, and unipolar depression). METHODS: Systematic literature search of Medline, Embase, and PsycInfo for studies on test-retest reliability of SAD, in CAD. Cohen's kappa was extracted from studies. We performed meta-analysis for kappa, including subgroup and sensitivity analysis (PROSPERO protocol: CRD42013006713)...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29358984/the-influence-of-planning-and-response-inhibition-on-cognitive-functioning-of-non-psychotic-unipolar-depressed-suicide-attempters
#18
Marco Moniz, Saul Neves de Jesus, Andreia Pacheco, Eduardo Gonçalves, João Viseu, Marta Brás, Dina Silva, Sílvia Batista
Depression is one of the main risk factors for suicide. However, little is known about the intricate relationships among depressive symptomatology in unipolar depression, suicide risk, and the characteristics of executive dysfunction in depressed patients. We compared 20 non-psychotic unipolar depressed suicide attempters to 20 matching depressed non-attempters and to 20 healthy controls to further investigate the possible differences in neuropsychological performance. Depressed subjects were controlled for current suicidal ideation, and their neuropsychological profile was assessed using a range of measures of executive functioning, attention, verbal memory, processing speed, and psychomotor speed...
November 2017: Europe's Journal of Psychology
https://www.readbyqxmd.com/read/29350128/between-a-rock-a-bye-and-a-hard-place-mood-disorders-during-the-peripartum-period
#19
Michael Thomson, Verinder Sharma
Mood disorders including major depressive disorder and bipolar disorder are common during and after pregnancy. Timely identification and appropriate management of mood episodes is essential to maximize maternal well-being and minimize adverse outcomes. Failure to do so results in maternal suffering and impaired child bonding, and has the potential for devastating outcomes including suicide and infanticide. Women are routinely screened for unipolar depression during or after pregnancy but not for bipolar disorder, in spite of the fact that childbirth is associated with a major risk for onset or exacerbation of bipolar disorder...
December 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29346806/lithium-and-renal-impairment-a-review-on-a-still-hot-topic
#20
René Ernst Nielsen, Lars Vedel Kessing, Willem A Nolen, Rasmus W Licht
INTRODUCTION: Lithium is established as an effective treatment of mania, of depression in bipolar and unipolar disorder, and in maintenance treatment of these disorders. However, due to the necessity of monitoring and concerns about irreversible adverse effects, in particular renal impairment, after long-term use, lithium might be underutilized. METHODS: This study reviewed 6 large observational studies addressing the risk of impaired renal function associated with lithium treatment and methodological issues impacting interpretation of results...
January 18, 2018: Pharmacopsychiatry
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