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idiopathic membranous

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https://www.readbyqxmd.com/read/29351334/endothelin-1-is-associated-with-fibrosis-in-proliferative-diabetic-retinopathy-membranes
#1
William Chang, Michelle Lajko, Amani A Fawzi
PURPOSE: To characterize the relationship between endothelin-1 and fibrosis in epiretinal membranes in proliferative diabetic retinopathy and explore the role of endothelial-mesenchymal transition in these membranes. METHODS: Membranes were obtained from eyes undergoing pars plana vitrectomy for complicated proliferative diabetic retinopathy or idiopathic epiretinal membrane. Through standard immunohistochemical techniques, we labeled membranes to explore the distribution of endothelin-1 and endothelin receptor B, comparing proliferative diabetic retinopathy and idiopathic epiretinal membranes...
2018: PloS One
https://www.readbyqxmd.com/read/29349731/membranous-nephropathy-associated-with-pregnancy-an-anti-phospholipase-a2-receptor-antibody-positive-case-report
#2
Eiichiro Uchino, Daisuke Takada, Haruta Mogami, Takeshi Matsubara, Tatsuo Tsukamoto, Motoko Yanagita
Pregnancy and membranous nephropathy (MN) can occur concurrently with nephrotic syndrome. However, the pathophysiology of MN associated with pregnancy remains unclear, including the involvement of anti-M-type phospholipase A2 receptor (PLA2R) antibody, the major antigen of idiopathic MN (iMN). A treatment for the condition is also not established. We present the case of a 43-year-old pregnant female with incidental proteinuria and hypoalbuminemia. We made a diagnosis of nephrotic syndrome at 11 week gestation...
January 18, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29346240/response-of-inflammatory-cystoid-macular-edema-to-treatment-using-oral-acetazolamide
#3
Kathryn L Pepple, Macklin H Nguyen, Kaivon Pakzad-Vaezi, Kathleen Williamson, Naomi Odell, Cecilia Lee, Thellea K Leveque, Russell N Van Gelder
PURPOSE: To determine the treatment effect of oral acetazolamide on refractory inflammatory macular edema. METHODS: A retrospective review of identified patients with uveitic or pseudophakic macular edema treated using acetazolamide between 2007 and 2014. Visual acuity and central macular subfield thickness was determined at baseline and at first follow-up. Baseline optical coherence tomography features were analyzed as predictors of acetazolamide response. RESULTS: Sixteen patients (19 eyes) of 61 screened met all criteria...
January 16, 2018: Retina
https://www.readbyqxmd.com/read/29340080/inhibition-of-tumor-necrosis-factor-signaling-attenuates-renal-immune-cell-infiltration-in-experimental-membranous-nephropathy
#4
Yen-Sung Huang, Shin-Huei Fu, Kuo-Cheng Lu, Jin-Shuen Chen, Hsin-Yi Hsieh, Huey-Kang Sytwu, Chia-Chao Wu
Idiopathic membranous nephropathy (MN) is an autoimmune-mediated glomerulonephritis and the most common cause of idiopathic nephrotic syndrome in adult humans. A tumor necrosis factor α (TNF-α)-mediated inflammatory response via TNF receptor 1 (TNFR1) and TNFR2 has been proposed as a pathogenic factor. In this study, we assessed the therapeutic response to blocking TNF signaling in experimental MN. Murine MN was induced experimentally by cationic bovine serum albumin (cBSA); phosphate-buffered saline was used in control mice...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29324930/characteristics-socioeconomic-status-and-ethnic-variations-of-primary-idiopathic-macular-hole-repair-in-vitreoretinal-centers-in-the-united-kingdom
#5
M Vasalaki, E Papavasileiou, S Velissaris, C Garnavou-Xirou, V Zygoura, O Theodorou, R Zakir, G Duguid, T Sandinha, D Steel, T L Jackson
OBJECTIVE: The purpose of this multicentre retrospective study was to investigate the characteristics and role of ethnicity and socioeconomic status amongst patients with idiopathic macular holes (IMH) and the surgical outcome. SUBJECTS AND METHOD: Consecutive patients undergoing primary IMH surgery at three vitreoretinal units in the UK (King's College Hospital, London, UK, Western Eye Hospital, London, UK, Sunderland Eye Infirmary, Sunderland, UK) between January 2007 and May 2017 were included...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29323413/extracorporeal-membrane-oxygenation-for-refractory-severe-respiratory-failure-in-acute-interstitial-pneumonia
#6
Gabriela Gonçalves-Venade, Nuno Lacerda-Príncipe, Roberto Roncon-Albuquerque, José Artur Paiva
Acute interstitial pneumonia (AIP) is a rare idiopathic interstitial lung disease with rapid progressive respiratory failure and high mortality. In the present report, three cases of AIP complicated by refractory respiratory failure supported with extracorporeal membrane oxygenation (ECMO) are presented. One male and two female patients (ages 27-59) were included. Venovenous ECMO support was provided using miniaturized systems, with two-site femoro-jugular circuit configuration. Despite lung protective ventilation, prone position and neuromuscular blockade, refractory respiratory failure of unknown etiology supervened (ratio of arterial oxygen partial pressure to fractional inspired oxygen 46-130) and ECMO was initiated after 3-7 days of mechanical ventilation...
January 11, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29298687/segmentation-error-in-spectral-domain-optical-coherence-tomography-measures-of-the-retinal-nerve-fibre-layer-thickness-in-idiopathic-intracranial-hypertension
#7
Anuriti Aojula, Susan P Mollan, John Horsburgh, Andreas Yiangou, Kiera A Markey, James L Mitchell, William J Scotton, Pearse A Keane, Alexandra J Sinclair
BACKGROUND: Optical Coherence Tomography (OCT) imaging is being increasingly used in clinical practice for the monitoring of papilloedema. The aim is to characterise the extent and location of the Retinal Nerve Fibre Layer (RNFL) Thickness automated segmentation error (SegE) by manual refinement, in a cohort of Idiopathic Intracranial Hypertension (IIH) patients with papilloedema and compare this to controls. METHODS: Baseline Spectral Domain OCT (SDOCT) scans from patients with IIH, and controls with no retinal or optic nerve pathology, were examined...
January 4, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29286956/five-year-incidence-and-risk-factors-for-idiopathic-epiretinal-membranes
#8
Jeong Hun Bae, Su Jeong Song, Mi Yeon Lee
PURPOSE: The aim of this was to determine the 5-year incidence of idiopathic epiretinal membrane (ERM) and its risk factors in Korean adults. METHODS: A total of 2,152 participants aged 50 years or older enrolled in a health screening program. All participants underwent baseline ophthalmic and systemic examinations in 2006, and were reexamined after 5 years. Epiretinal membranes were diagnosed using fundus photographs taken at baseline and at the 5-year follow-up...
December 28, 2017: Retina
https://www.readbyqxmd.com/read/29285122/pathophysiological-correlations-between-fundus-fluorescein-angiography-and-optical-coherence-tomography-results-in-patients-with-idiopathic-epiretinal-membranes
#9
Ju Liu, Yong Qian, Shunnan Yang, Li Yan, Yi Wang, Meng Gao, Limei Liu, Yuanyuan Xiao, Bin Mo, Wu Liu
The aim of the current study was to determine the association between fundus fluorescein angiography (FFA) image results, optical coherence tomography (OCT) imaging results and visual functions in patients with idiopathic epiretinal membranes (ERMs). A total of 80 eyes from 40 patients diagnosed with ERM were analyzed. Best-corrected visual acuity (BCVA) and metamorphopsia were measured using the Early Treatment Diabetic Retinopathy Study eye chart and M-charts, respectively. Macular thickness and volume were determined using OCT...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29284451/synovial-inflammation-plays-a-greater-role-in-post-traumatic-osteoarthritis-compared-to-idiopathic-osteoarthritis-in-the-hartley-guinea-pig-knee
#10
Nathan P Thomas, Wesley J Wu, Braden C Fleming, Fangyuan Wei, Qian Chen, Lei Wei
BACKGROUND: The objective of this study was to evaluate the extent of stromal cell-derived factor-1's (SDF-1) involvement in the pathogenesis of idiopathic versus post-traumatic OA by comparing differences in synovial membrane morphology, SDF-1 synovial fluid (SF) concentrations, and matrix metalloproteinase-13 (MMP-13) SF concentrations. METHODS: Thirty-six 3-month-old Hartley guinea pigs were obtained and divided into 6 groups. Upon sacrifice, India Ink staining was used to evaluate gross morphology, Safranin O/Fast green staining was used to assess cartilage damage, H/E staining was employed to visualize the synovium, and SF samples were obtained for biochemical analyses...
December 29, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29276228/retinal-nerve-fiber-layer-defect-and-paracentral-scotoma-after-internal-limiting-membrane-peeling-with-a-nitinol-loop
#11
Ryo Matoba, Yuki Morizane, Shuhei Kimura, Shinji Toshima, Fumio Shiraga
Internal limiting membrane (ILM) peeling is an important maneuver in vitrectomy for macular holes (MHs). A nitinol loop is a surgical instrument designed to create an edge on the ILM and peel the ILM safely and consistently. The effect of using a nitinol loop for ILM peeling on the retina is not clear. We report here on a case of an idiopathic full-thickness MH in an adult woman, in whom retinal damage was revealed after her ILM was peeled using a nitinol loop.
December 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29275531/renal-phosphate-handling-and-inherited-disorders-of-phosphate-reabsorption-an-update
#12
REVIEW
Carsten A Wagner, Isabel Rubio-Aliaga, Nati Hernando
Renal phosphate handling critically determines plasma phosphate and whole body phosphate levels. Filtered phosphate is mostly reabsorbed by Na+-dependent phosphate transporters located in the brush border membrane of the proximal tubule: NaPi-IIa (SLC34A1), NaPi-IIc (SLC34A3), and Pit-2 (SLC20A2). Here we review new evidence for the role and relevance of these transporters in inherited disorders of renal phosphate handling. The importance of NaPi-IIa and NaPi-IIc for renal phosphate reabsorption and mineral homeostasis has been highlighted by the identification of mutations in these transporters in a subset of patients with infantile idiopathic hypercalcemia and patients with hereditary hypophosphatemic rickets with hypercalciuria...
December 23, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29259907/the-impact-of-macular-surgery-in-different-grades-of-epiretinal-membrane
#13
Cosar Batman, Mehmet Citirik
AIM: To assess the impact of macular surgery on the functional and anatomic outcomes of the patients in different grades of epiretinal membrane (ERM). METHODS: Seventy-one eyes of 71 patients who underwent 23-gauge transconjunctival sutureless pars plana vitrectomy for primary isolated ERM were evaluated in this study. RESULTS: There were 38 females (53.5%) and 33 males (46.5%). The average age of the patients was 68.1y (range 42-89y). Mean follow up period was 14mo (range 6-26mo)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29247494/podocyte-and-endothelial-cell-injury-develop-nephrotic-syndrome-in-proliferative-lupus-nephritis
#14
Aya Nawata, Satoshi Hisano, Shohei Shimajiri, Ke-Yong Wang, Yoshiya Tanaka, Toshiyuki Nakayama
AIMS: Nephrotic syndrome (NS) is a major manifestation of lupus nephritis (LN). The dysregulation of podocyte, glomerular basement membrane (GBM) and endothelial cell (EC) develops proteinuria in glomerular diseases. The aim of our study is to clarify whether the dysregulation of these barriers is associated with NS in proliferative LN and membranous LN. METHODS AND RESULTS: Fifty six patients with NS including minimal change NS in 15, primary membranous nephropathy (PMN) in 13, Class III/IV LN in 15 and Class V LN in 13 were enrolled in this study...
December 15, 2017: Histopathology
https://www.readbyqxmd.com/read/29243784/value-of-immunofluorescence-mediated-detection-of-ig-c1q-c3-and-fra-for-the-identification-and-diagnosis-of-atypical-membranous-nephropathy
#15
W-X Wang, C-Y Hu
OBJECTIVE: The present study was to investigate the value of immunofluorescence-mediated detection of Ig, C1q, C3, and FRA for the identification and diagnosis of atypical membranous nephropathy (AMN). PATIENTS AND METHODS: Fifty-five patients with AMN and 135 patients with idiopathic membranous nephropathy (IMN) diagnosed by renal biopsy in our hospital were consecutively selected. The positive expressions of Ig, C1q, C3, and FRA by immunofluorescence were analyzed...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29232338/internal-limiting-membrane-peeling-versus-inverted-flap-technique-for-treatment-of-full-thickness-macular-holes-a-comparative-study-in-a-large-series-of-patients
#16
Stanislao Rizzo, Ruggero Tartaro, Francesco Barca, Tomaso Caporossi, Daniela Bacherini, Fabrizio Giansanti
BACKGROUND: The inverted flap (IF) technique has recently been introduced in macular hole (MH) surgery. The IF technique has shown an increase of the success rate in the case of large MHs and in MHs associated with high myopia. This study reports the anatomical and functional results in a large series of patients affected by MH treated using pars plana vitrectomy and gas tamponade combined with internal limiting membrane (ILM) peeling or IF. METHODS: This is a retrospective, consecutive, nonrandomized comparative study of patients affected by idiopathic or myopic MH treated using small-gauge pars plana vitrectomy (25- or 23-gauge) between January 2011 and May 2016...
December 8, 2017: Retina
https://www.readbyqxmd.com/read/29232330/foveal-avascular-zone-area-analysis-using-optical-coherence-tomography-angiography-before-and-after-idiopathic-epiretinal-membrane-surgery
#17
Yorihisa Kitagawa, Hiroyuki Shimada, Ari Shinojima, Hiroyuki Nakashizuka
PURPOSE: To determine the size of the foveal avascular zone (FAZ) by optical coherence tomography angiography before and after idiopathic epiretinal membrane surgery. METHODS: Thirteen consecutive patients (13 eyes) with unilateral epiretinal membrane were studied retrospectively. Optical coherence tomography angiography was used to measure the FAZ area within 3 mm × 3 mm scans of the superficial (superficial FAZ) and deep plexus layers (deep FAZ) before and 6 months after vitrectomy...
December 11, 2017: Retina
https://www.readbyqxmd.com/read/29221341/atypical-carcinoid-localized-at-the-bronchus-accompanied-by-diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia-in-the-distal-lung-a-rare-case-report
#18
Kyoshiro Takegahara, Akira Sato, Takayuki Ibi, Tatsuya Inoue, Jitsuo Usuda
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is hyperplasia of noninvasive neuroendocrine cells originating from Kultchitsky cells. This is a rare pathological condition, suspected to be a precursor lesion of carcinoid, together with tumorlet. In the WHO histological classification (4th edition) revised in 2015, DIPNECH was added to the category that includes neuroendocrine tumors. Our patient was a 77-year-old woman who initially visited another doctor because of coughing. Chest CT revealed a mass occluding the right intermediate bronchial trunk, and bronchial carcinoid was suspected from biopsy findings, leading to referral of this patient to our department...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29219899/clinical-outcomes-using-oversized-back-plates-in-type-i-boston-keratoprosthesis
#19
Aaron R Kaufman, Andrea Cruzat, Kathryn A Colby
OBJECTIVES: To examine clinical outcomes of oversized titanium back plates in type I Boston keratoprosthesis (KPro) implantation. METHODS: Retrospective study of 22 sequential eyes (20 patients) undergoing type I KPro implantation with an oversized titanium back plate (larger than trephined wound diameter by 1.0 mm or more), performed by a single surgeon (K.A.C.) from June 2010 to November 2014. Data were collected regarding preoperative eye characteristics, surgical details, and postoperative clinical outcomes...
December 5, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29218950/-meta-analysis-of-yiqi-huoxue-method-in-treating-idiopathic-membranous-nephropathy
#20
Qi-Yan Zheng, Lu-Ying Sun, Hua-Nan Jin, Qian Zhou, Wen Zhang, Ya-Hui Wang
The incidence of idiopathic membranous nephropathy (IMN) is increasing year by year, and the clinical research on Chinese medicine treatment of INM is also growing. This study aims to evaluate the efficiency and safety of Yiqi Huoxue method for IMN. Data sources used were from PubMed, EMbase, the Cochrane Library, CBM, CNKI, Wanfang and VIP database. Two researchers independently screened the literature and extracted data. RevMan 5.3 software was used for Meta analysis, and the evidences were graded for the outcomes according to GRADE system by using GRADEprofiler 3...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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