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idiopathic membranous

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https://www.readbyqxmd.com/read/28221139/how-do-stones-form-is-unification-of-theories-on-stone-formation-possible
#1
Victoria Y Bird, Saeed R Khan
There are two basic pathways for formation of calcium based kidney stones. Most idiopathic calcium oxalate (CaOx) stones are formed in association with sub-epithelial plaques of calcium phosphate (CaP), known as Randall's plaques, on renal papillary surfaces. Crystal formation and retention within the terminal collecting ducts, the ducts of Bellini, leading to the formation of Randall's plugs, is the other pathway. Both pathways require supersaturation leading to crystallization, regulated by various crystallization modulators produced in response to changing urinary conditions...
January 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28207608/effects-of-internal-limiting-membrane-peeling-combined-with-removal-of-idiopathic-epiretinal-membrane-a-systematic-review-of-literature-and-meta-analysis
#2
Kunihiro Azuma, Takashi Ueta, Shuichiro Eguchi, Makoto Aihara
PURPOSE: To evaluate the effects on postoperative prognosis of internal limiting membrane (ILM) peeling in conjunction with removal of idiopathic epiretinal membranes (ERMs). METHODS: MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE were systematically searched for studies that compared ILM peeling with no ILM peeling in surgery to remove idiopathic ERM. Outcome measures were best-corrected visual acuity, central macular thickness, and ERM recurrence...
February 15, 2017: Retina
https://www.readbyqxmd.com/read/28203411/development-of-a-non-infectious-rat-model-of-acute-exacerbation-of-idiopathic-pulmonary-fibrosis
#3
Shan-Shan Chen, Zhao-Fang Yin, Tao Chen, Hui Qiu, Ya-Ru Wei, Shan-Shan Du, Yue-Ping Jin, Meng-Meng Zhao, Qin Wu, Dong Weng, Hui-Ping Li
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease with severe pulmonary fibrosis. The main cause of IPF-associated death is acute exacerbation of IPF (AE-IPF). This study aims to develop a rat model of AE-IPF by two intratracheal perfusions with bleomycin (BLM). METHODS: Ninety male Sprague Dawley (SD) rats were randomized into three groups: an AE-IPF model group (BLM + BLM group), an IPF model group (BLM group), and a normal control group...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28202222/early-initiation-of-immunosuppressive-treatment-in-membranous-nephropathy-patients
#4
Chieh Kai Chan, Tai Shuan Lai, Ping Min Chen, Yu Hsiang Chou, Ching Fang Wu, Yen Ling Chiu, Wen Chih Chiang, Yung Ming Chen, Tzong-Shinn Chu, Kwan Dun Wu
BACKGROUND: Suggestion for the management of idiopathic membranous nephropathy (IMN) includes 6 months of observation, followed with steroid plus alkylating agent. However, delayed immunosuppression exposes the kidneys to persistent damage. This study aimed to examine the benefit of early immunosuppression in IMN patients. METHOD: A retrospective study was performed. From 1993 to 2013, 161 IMN patients were enrolled. Patients receiving immunosuppression within 6 months after diagnosis were classified as initial-treatment group, whereas other patients as initial-no-treatment group...
February 12, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28196052/association-between-tangential-contraction-and-early-vision-loss-in-idiopathic-epiretinal-membrane
#5
Seung Min Lee, Kang Yeun Pak, Han Jo Kwon, Sung Who Park, Ji Eun Lee, Ik Soo Byon
PURPOSE: To investigate the clinical features associated with early visual loss in patients with idiopathic epiretinal membrane. METHODS: Patients with idiopathic epiretinal membrane with visual acuity of ≥20/40, intact ellipsoid zone, and follow-up duration of at least 24 months were included in this retrospective age-matched control study. The disk-fovea-vascular (DFV) distance, central macular thickness, membrane configuration, and ellipsoid zone were assessed using fundus photography and spectral domain optical coherence tomography...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28190800/cocoon-carcinomatosa-an-unusual-cause-of-intestinal-obstruction
#6
Jimil Shah, Amit Kumar, Harjeet Singh, Roshan Agarwala, Vishal Sharma, Surinder S Rana
Abdominal cocoon, also termed sclerosing encapsulating peritonitis, is an uncommon entity associated with formation of a fibro-collagenous membrane around intestinal loops resulting in intestinal obstruction. Most reported cases are idiopathic, but many other causes have been implicated in cocoon formation, including use of continuous ambulatory peritoneal dialysis, peritoneal tuberculosis, and connective tissue disease. However, peritoneal carcinomatosis is a rarely reported entity that causes this condition...
February 13, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28161828/macular-hole-closure-patterns-associated-with-different-internal-limiting-membrane-flap-techniques
#7
Tommaso Rossi, Aldo Gelso, Ciro Costagliola, Carlandrea Trillo, Annalisa Costa, Carlo Gesualdo, Guido Ripandelli
PURPOSE: To compare the anatomic and functional outcome of two variants of the inverted internal limiting membrane (I-ILM) flap technique for idiopathic macular holes (IMH) larger than 400 µm. METHODS: Twenty-seven consecutive patients undergoing PPV for IMH were randomly assigned to different variants of I-ILM technique: the Cover group included 14 patients in which the I-ILM was folded upside-down over the MH as a single layer while the Fill group enrolled 13 patients in which the I-ILM was folded within the MH in multiple layers...
February 4, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28147208/systemic-granulomatous-and-haemorrhagic-syndrome-in-new-zealand-dairy-cattle
#8
T G Rawdon, K N Buckle, K E Lawrence, K G Thompson, A F Julian, B L Vaatstra, A C Johnstone, J F Weston, R A Fairley
CASE HISTORY: Cases were obtained through passive surveillance reporting by veterinary pathologists, via the Ministry for Primary Industries Exotic Pest and Disease Hotline. They included ill or dead cows that had evidence of frank haemorrhage, petechial haemorrhages on mucous membranes, wasting or dermatitis of unknown cause, and were reported between 2009-2014. Affected cows (n=16) were from nine seasonally calving dairy farms, aged ≥3 years, and were predominantly in their mid-to-late non-lactating period...
February 1, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28146110/polyphenolic-extract-of-euphorbia-supina-attenuates-manganese-induced-neurotoxicity-by-enhancing-antioxidant-activity-through-regulation-of-er-stress-and-er-stress-mediated-apoptosis
#9
Entaz Bahar, Geum-Hwa Lee, Kashi Raj Bhattarai, Hwa-Young Lee, Min-Kyung Choi, Harun-Or Rashid, Ji-Ye Kim, Han-Jung Chae, Hyonok Yoon
Manganese (Mn) is an important trace element present in human body, which acts as an enzyme co-factor or activator in various metabolic reactions. While essential in trace amounts, excess levels of Mn in human brain can produce neurotoxicity, including idiopathic Parkinson's disease (PD)-like extrapyramidal manganism symptoms. This study aimed to investigate the protective role of polyphenolic extract of Euphorbia supina (PPEES) on Mn-induced neurotoxicity and the underlying mechanism in human neuroblastoma SKNMC cells and Sprague-Dawley (SD) male rat brain...
January 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28143416/combination-therapy-with-rituximab-low-dose-cyclophosphamide-and-prednisone-for-idiopathic-membranous-nephropathy-a-case-series
#10
Frank B Cortazar, David E Leaf, Charles T Owens, Karen Laliberte, William F Pendergraft, John L Niles
BACKGROUND: Membranous nephropathy is a common cause of the nephrotic syndrome. Treatment with standard regimens fails to induce complete remission in most patients. We evaluated the efficacy of combination therapy with rituximab, low-dose, oral cyclophosphamide, and an accelerated prednisone taper (RCP) for the treatment of idiopathic membranous nephropathy. METHODS: We analyzed 15 consecutive patients with idiopathic membranous nephropathy treated with RCP at Massachusetts General Hospital...
February 1, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28137906/idiosyncratic-drug-reactions-and-membranous-glomerulopathy
#11
Amrit Kirpalani, Michael J Rieder, Kevin C Bax, Guido Filler
An infant boy with steroid-resistant nephrotic syndrome (idiopathic membranous glomerulonephropathy) achieved remission with ciclosporin but developed eosinophilia and high IgE levels (max 19 000  iU/mL). Conversion to tacrolimus resulted in chronic diarrhoea (eosinophilic gastroenteritis), muscle weakness, polyserositis and failure-to-thrive. In contrast, a trial without tacrolimus resulted in a ciclosporin-responsive relapse, therapy-resistant focal seizures with generalised spikes, worsening muscle weakness and diarrhoea...
January 30, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28134731/lichen-planus-with-predominate-plasma-cell-infiltrate-two-case-reports
#12
Huyenlan Dinh, Jennifer Seyffert, Nektarios I Lountzis, Howard B Altman, Christian Oram, Stephen M Purcell
Lichen planus (LP) is a mucocutaneous inflammatory dermatitis of idiopathic origin that can involve the skin, mucous membranes, hair, and nails. LP has an associated set of characteristic histopathologic findings which include hyperkeratosis, vacuolization of the basal layer, Civatte bodies, wedge-shaped hypergranulosis, band-like lymphocytic infiltrate at the dermal epidermal junction, eosinophilic colloid bodies in the papillary dermis, and pigment incontinence. The infiltrate is usually composed of lymphocytes with few histiocytes, mast cells, and macrophages...
February 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28129215/inverted-internal-limiting-membrane-flap-technique-for-macular-hole-surgery-without-extra-manipulation-of-the-flap
#13
Giamberto Casini, Marco Mura, Michele Figus, Pasquale Loiudice, Enrico Peiretti, Stefano De Cillà, Taiusha Fuentes, Francesco Nasini
PURPOSE: To determine whether surgical manipulation steps of the internal limiting membrane (ILM) flap, such as ILM trimmed, ILM tuck inside the hole, ILM massage, are mandatory to obtain satisfactory outcomes for the repair of large stage IV idiopathic macular hole using the inverted ILM flap technique. METHODS: In this interventional comparative prospective single-masked study, 81 eyes were randomized into 2 treatments groups. In Group 1 (41 eyes), the classic inverted ILM flap technique was performed...
January 26, 2017: Retina
https://www.readbyqxmd.com/read/28126025/anti-inflammatory-properties-of-amniotic-membrane-patch-following-pericardiectomy-for-constrictive-pericarditis
#14
Katherine M Marsh, Alice S Ferng, Tia Pilikian, Ankit A Desai, Ryan Avery, Mark Friedman, Isabel Oliva, Clint Jokerst, David Schipper, Zain Khalpey
BACKGROUND: Since constrictive pericarditis is most often idiopathic and the pathophysiology remains largely unknown, both the diagnosis and the treatment can be challenging. However, by definition, inflammatory processes are central to this disease process. Amniotic membrane patches have been shown to possess anti-inflammatory properties and are believed to be immune privileged. Due to these properties, amniotic membrane patches were applied intraoperatively in a complicated patient presenting with constrictive pericarditis...
January 26, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28125840/association-of-high-mobility-group-box-1-with-th-cell-related-cytokines-in-the-vitreous-of-ocular-sarcoidosis-patients
#15
Masaru Takeuchi, Manzo Taguchi, Tomohito Sato, Kyoko Karasawa, Yutaka Sakurai, Kohzou Harimoto, Masataka Ito
Purpose: High-mobility group box-1 (HMGB1) is a nonhistone DNA-binding nuclear protein released from necrotic cells, which is also secreted by activated leukocytes and acts as a primary proinflammatory cytokine. In this study, we compared vitreous HMGB1 levels in ocular sarcoidosis with those in noninflammatory vitreoretinal diseases and evaluated its association with Th cell-related and proinflammatory cytokines. Methods: The study group consisted of 24 patients with ocular sarcoidosis...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28108904/intravitreal-anti-vegf-treatment-for-subretinal-neovascularisation-secondary-to-type-2-idiopathic-juxtafoveolar-telangiectasia
#16
Teresa Barth, Florian Zeman, Horst Helbig, Maria-Andreea Gamulescu
PURPOSE: To assess the long-term outcome of patients with subretinal neovascular membrane (SRNVM) secondary to type 2 idiopathic juxtafoveolar telangiectasia (IJT) receiving intravitreal anti-VEGF (vascular endothelial growth factor) injections. METHODS: A total of 14 eyes of 12 patients treated with intravitreal anti-VEGF for SRNVM related to type 2 IJT were retrospectively assessed. RESULTS: Nine men and 3 women with a mean age of 66 years (SD 12, range 47-87 years) were diagnosed with IJT-related SRNVM...
January 21, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28102455/soluble-form-of-lr11-is-highly-increased-in-the-vitreous-fluids-of-patients-with-idiopathic-epiretinal-membrane
#17
Ryuya Hashimoto, Meizi Jiang, Tomoaki Shiba, Nobuyuki Hiruta, Mao Takahashi, Morihiro Higashi, Yuichi Hori, Hideaki Bujo, Takatoshi Maeno
PURPOSE: LR11 (also called SorLA or SORL1) is a migration regulator of adherent cells with the immature proliferative phenotype. The present study investigated the clinical and pathological involvement of the soluble form of LR11 (sLR11) in the idiopathic epiretinal membrane (iERM). METHODS: The subjects were 51 patients with iERM (24 cellophane macular reflex (CMR) and 27 preretinal macular fibrosis (PMF)) and 45 patients with macular holes as age and sex-matched controls...
January 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28101144/histopathological-findings-in-systemic-sclerosis-related-myopathy-fibrosis-and-microangiopathy-with-lack-of-cellular-inflammation
#18
Claudio Corallo, Maurizio Cutolo, Nila Volpi, Daniela Franci, Margherita Aglianò, Antonio Montella, Chiara Chirico, Stefano Gonnelli, Ranuccio Nuti, Nicola Giordano
OBJECTIVES: The objective of this study was to identify specific histopathological features of skeletal muscle involvement in systemic sclerosis (SSc) patients. METHODS: A total of 35 out of 112 SSc-patients (32%, including 81% female and 68% diffuse scleroderma) presenting clinical, biological and electromyographic (EMG) features of muscle weakness, were included. Patients underwent vastus lateralis biopsy, assessed for individual pathologic features including fibrosis [type I collagen (Coll-I), transforming growth factor β (TGF-β)], microangiopathy [cluster of differentiation 31 (CD31), pro-angiogenic vascular endothelial growth factor A (VEGF-A), anti-angiogenic VEGF-A165b], immune/ inflammatory response [CD4, CD8, CD20, human leucocyte antigens ABC (HLA-ABC)], and membranolytic attack complex (MAC)...
January 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28098723/assessment-of-the-internal-limiting-membrane-status-when-a-macular-epiretinal-membrane-is-removed-in-a-prospective-study
#19
Daniel Vila Solà, Cristofer Nienow, Ignasi Jürgens
PURPOSE: To describe the presence and integrity of the internal limiting membrane (ILM) after removal of the macular epiretinal membrane (ERM) and to investigate the accuracy of tissue identification using surgical dyes when compared to histopathology results. METHODS: Patients with idiopathic ERM were enrolled in a prospective study and randomized to one of two surgical techniques. In one (Group M), only the ERM was deliberately removed and in the other (Group L) the ILM was also removed...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098116/membranous-glomerulopathy-and-massive-cervical-lymphadenopathy-due-to-immunoglobulin-g4-disease
#20
Kamel El-Reshaid, Shaikha Al-Bader, John Madda
A 32-year-old male presented with acute and severe nephrotic syndrome as well as massive right cervical lymphadenopathy for <2 years. Computed tomography scan of the chest, abdomen, and pelvis did not reveal any lymphadenopathy. Histopathology and immunohistochemical testing of his lymph node biopsy showed infiltrate enriched with immunoglobulin G4 (IgG4)-positive plasma cells. His kidney biopsy showed granular membranous deposits of IgG4 in the basement membrane without interstitial infiltrate. Antiphospholipid 2 receptor antibodies were absent excluding its "idiopathic" nature...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
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