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pulmonary tuberculosis in diabetes mellitus

Sarah Lou Bailey, Helen Ayles, Nulda Beyers, Peter Godfrey-Faussett, Monde Muyoyeta, Elizabeth du Toit, John S Yudkin, Sian Floyd
BACKGROUND: Systematic reviews suggest that the incidence of diagnosed tuberculosis is two- to- three times higher in those with diabetes mellitus than in those without. Few studies have previously reported the association between diabetes or hyperglycaemia and the prevalence of active tuberculosis and none in a population-based study with microbiologically-defined tuberculosis. Most have instead concentrated on cases of diagnosed tuberculosis that present to health facilities. We had the opportunity to measure glycaemia alongside prevalent tuberculosis...
December 5, 2016: BMC Infectious Diseases
Magna Manjareeka, Subrata Kumar Palo, Subhashisa Swain, Sandipana Pati, Sanghamitra Pati
INTRODUCTION: The association between Diabetes Mellitus (DM) and Tuberculosis (TB) poses a strong public health challenge. Tribal ethnics possess a different propensity towards infectious and haematological diseases which may influence the inter-relationship of DM and TB and thus merit separate attention. AIM: To investigate the prevalence of diabetes in newly diagnosed pulmonary TB patients of tribal ethnicity in Odisha. MATERIALS AND METHODS: A cross-sectional study was carried out over a period of 9 months at four designated TB microscopic centres in a tribal district (Malkangiri) of Odisha...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
Nathella Pavan Kumar, Kadar Moideen, Shanmugam Sivakumar, Pradeep A Menon, Vijay Viswanathan, Hardy Kornfeld, Subash Babu
Type 2 diabetes mellitus (DM) is a major risk factor for the development of active pulmonary tuberculosis (PTB), with development of DM pandemic in countries where tuberculosis (TB) is also endemic. However, the effect of anti-TB treatment on the changes in dentritic cell (DC) and monocyte subset phenotype in TB-DM co-morbidity is not well understood. In this study, we characterized the frequency of DC and monocyte subsets in individuals with PTB with (PTB-DM) or without coincident diabetes mellitus (PTB-NDM) before, during and after completion of anti-TB treatment...
December 2016: Tuberculosis
Satyanarayana Swamy Cheekatla, Deepak Tripathi, Sambasivan Venkatasubramanian, Pavan Kumar Nathella, Padmaja Paidipally, Munenori Ishibashi, Elwyn Welch, Amy R Tvinnereim, Mitsuo Ikebe, Vijaya Lakshmi Valluri, Subash Babu, Hardy Kornfeld, Ramakrishna Vankayalapati
In this study, we developed a mouse model of type 2 diabetes mellitus (T2DM) using streptozotocin and nicotinamide and identified factors that increase susceptibility of T2DM mice to infection by Mycobacterium tuberculosis (Mtb). All Mtb-infected T2DM mice and 40% of uninfected T2DM mice died within 10 months, whereas all control mice survived. In Mtb-infected mice, T2DM increased the bacterial burden and pro- and anti-inflammatory cytokine and chemokine production in the lungs relative to those in uninfected T2DM mice and infected control mice...
October 2016: PLoS Pathogens
Bassent E Abdelbary, Moncerrato Garcia-Viveros, Horacio Ramirez-Oropesa, Mohammad H Rahbar, Blanca I Restrepo
Type 2 diabetes mellitus (DM) is a re-emerging risk factor for TB development and adverse TB outcomes. As a follow-up of our previous study in 1998-2004, we reassessed prevalence of DM and its associated factors among 8431 TB patients using surveillance data from 2006 to 2013 for the Mexican state of Tamaulipas, across the border with Texas. Prevalence of DM was 25.2%, with an increase of at least 2.8% over the study period. Newly discovered factors associated with TB-DM (versus no DM) were lower education and higher unemployment (p < 0...
December 2016: Tuberculosis
M Senkoro, A M V Kumar, P Chinnakali, S G Mfinanga, S Egwaga, V Kamara, F van Leth, S G Hinderaker
SETTING: Tanzania has an estimated tuberculosis (TB) prevalence of 295 per 100 000 adult population. There is currently no nationally representative information on factors associated with TB in Tanzania. OBJECTIVE: To determine the demographic and clinical factors associated with bacteriologically confirmed TB in the adult general population of Tanzania. DESIGN: A case-control study nested in a nationally representative TB prevalence survey...
October 2016: International Journal of Tuberculosis and Lung Disease
Helder Novais Bastos, Nuno S Osório, António Gil Castro, Angélica Ramos, Teresa Carvalho, Leonor Meira, David Araújo, Leonor Almeida, Rita Boaventura, Patrícia Fragata, Catarina Chaves, Patrício Costa, Miguel Portela, Ivo Ferreira, Sara Pinto Magalhães, Fernando Rodrigues, Rui Sarmento-Castro, Raquel Duarte, João Tiago Guimarães, Margarida Saraiva
Tuberculosis imposes high human and economic tolls, including in Europe. This study was conducted to develop a severity assessment tool for stratifying mortality risk in pulmonary tuberculosis (PTB) patients. A derivation cohort of 681 PTB cases was retrospectively reviewed to generate a model based on multiple logistic regression analysis of prognostic variables with 6-month mortality as the outcome measure. A clinical scoring system was developed and tested against a validation cohort of 103 patients. Five risk features were selected for the prediction model: hypoxemic respiratory failure (OR 4...
2016: PloS One
Ravish Kshatriya, Viral Patel, Sanjay Chaudhari, Purvesh Patel, Dhaval Prajapati, Nimit Khara, Rajiv Paliwal, Sateesh Patel
Pulmonary tuberculosis is commonly presented as cavitary lesion and infiltrations. It commonly involves upper lobe. Lower lobe involvement is less common. Various atypical presentations of tuberculosis on radiology are reported like mass, solitary nodule, multi lober involvement including lower lobes. Atypical presentations are more commo in patients with immunocompromised conditions like Diabetes Mellitus, anemia, renal failure, liver diseases, HIV infection, malignancy, patients on immunosuppressive therapy...
September 2016: Lung India: Official Organ of Indian Chest Society
Takashi Ishiguro, Naho Kagiyama, Ryuji Uozumi, Kyuto Odashima, Kazuyoshi Kurashima, Satoshi Morita, Noboru Takayanagi
Comorbidity is known to be associated with the severity and mortality of pneumonia. The severity of each underlying disease varies, and performance status, which is known to be a prognostic factor of malignant diseases, reflects the overall patient condition as affected by his/her comorbidity and underlying diseases of various severity. We investigated whether premorbid patients' performance status is associated with the severity and mortality of pneumococcal pneumonia. This retrospective study assessed these factors in hospitalized patients suffering from pneumococcal pneumonia from 2002 to 2015...
October 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Young Soon Yoon, Jae-Woo Jung, Eun Ju Jeon, Haesook Seo, Yon Ju Ryu, Jae-Joon Yim, Yee Hyung Kim, Byoung-Hoon Lee, Yong Bum Park, Byoung Jun Lee, Hyun Kang, Jae Chol Choi
BACKGROUND: Uncontrolled diabetes, unlike controlled diabetes, is associated with an impaired immune response. However, little is known about the impact of the status of diabetes control on clinical features and treatment outcomes in patients with pulmonary TB (PTB). We conducted this study to evaluate whether the status of diabetes control influences clinical manifestations and treatment responses in PTB. METHODS: A multicentre prospective study was performed between September 2012 and September 2014...
August 23, 2016: Thorax
Cihadiye Elif Öztürk, İdris Şahin, Şükrü Öksüz, Nida Kılıç, Özge Kılınçel, Leyla Aydın, Dursun Atik, Emine Afşin
Throughout the history of mankind, tuberculosis (TB) has caused serious illness and still continues to do so. Archaeobiological studies indicated that TB in humans dates back to 4000-8000 BC, and cases were shown to be due to Mycobacterium bovis subsp.bovis rather than Mycobacterium tuberculosis. Moreover, this situation was thought to begin with domestication of animals, consumption of their milk, and living together in the same environment with them. Over time, with the consumption of boiled milk and with the establishment of separate animal shelters, M...
July 2016: Mikrobiyoloji Bülteni
Jae-Won Yun, Mia Son
Forecasting cause-specific mortality can help estimate the future burden of diseases and provide a clue for preventing diseases. Our objective was to forecast the mortality for causes of death in the future (2013-2032) based on the past trends (1983-2012) in Korea. The death data consisted of 12 major causes of death from 1983 to 2012 and the population data consisted of the observed and estimated populations (1983-2032) in Korea. The modified age-period-cohort model with an R-based program, nordpred software, was used to forecast future mortality...
August 2016: Journal of Korean Medical Science
Chung-Kuan Wu, Jyh-Gang Leu, Cheng-Chun Wei, Shih-Chung Hsieh
BACKGROUND: Acute thrombosis of a transplanted renal artery is a serious vascular complication following renal allograft transplantation, which usually occurs within the first month after transplantation and often results in graft loss. It rarely occurs beyond the first month, except in a rejected kidney or in a kidney with high-grade transplant renal artery stenosis. RESULT: A 65-year-old male with a history of type 2 diabetes mellitus, hypertension, pulmonary tuberculosis, and end-stage renal disease was previously treated with hemodialysis (HD)...
July 2016: Medicine (Baltimore)
Parvaneh Baghaei, Payam Tabarsi, Pedram Javanmard, Parissa Farnia, Majid Marjani, Afshin Moniri, Mohammad Reza Masjedi, Ali Akbar Velayati
The objectives of this study were to determine the impact of diabetes mellitus (DM) on antituberculosis drug resistance in new cases of tuberculosis (TB). A case-control study was conducted on all newly diagnosed pulmonary TB adult patients with DM as cases and without DM as controls who were hospitalised from May 2013 to October 2013 in Iran. A molecular resistance test for rapid detection of resistance to isoniazid and rifampicin was done. Multivariate analysis was performed to determine the impact of DM on any anti-TB drug resistance...
March 2016: Journal of Global Antimicrobial Resistance
Tsai-Ling Liao, Chin-Fu Lin, Yi-Ming Chen, Hung-Jen Liu, Der-Yuan Chen
Increasing evidence indicates that the risk of nontuberculous mycobacteria (NTM) disease is elevated in patients with rheumatoid arthritis (RA). However, the risk factors and outcomes for NTM disease among RA patients remain unclear. We conducted a case-control study and estimated odds ratios (ORs) for RA patients with NTM disease according to comorbidities and anti-rheumatic medications by using conditional logistic regression. Prior tuberculosis history (adjusted OR (aOR) =5.58, p < 0.001), hypertension (aOR = 2...
2016: Scientific Reports
S Sharma, P Gupta, N Gupta, A Lal, D Behera, A Rajwanshi
OBJECTIVE: To evaluate the role of fine needle aspiration cytology (FNAC) in the diagnosis of pulmonary infections in immunocompromised patients and to identify the imaging pattern of infections on computed tomography (CT). MATERIALS AND METHODS: This was a retrospective study of 42 immunocompromised patients who underwent FNAC under image guidance owing to a clinical pulmonary infection. Each patient was evaluated for an underlying immunocompromised condition, cytological diagnosis, CT findings and complications...
June 13, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
Ljiljana Simonovska, Irfan Ahmeti, Vladimir Mitreski
BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is associated with evidence of systemic oxidative stress, activation of circulating inflammatory cells and increased plasma level of proinflamatory cytokines which include C-reactive protein (CRP). CRP is one biomarker of extrapulmonary or systemic consequences of COPD that can be detected. AIM: The aim of this research is to determine whether the level of CRP statistically significantly correlates with the level of bronchial obstruction and the accompanying co-morbidities in patients with COPD...
June 15, 2015: Open Access Maced J Med Sci
Alejandra Montoya-Rosales, Pamela Castro-Garcia, Flor Torres-Juarez, Jose Antonio Enciso-Moreno, Bruno Rivas-Santiago
Diabetes mellitus (DM)-2 patients have an increased susceptibility to develop pulmonary tuberculosis; this is partly due to the impairment of the innate immunity because of their higher glucose concentrations. In the present study, we determined the effect of the glucose concentrations in the LL-37 expression in infected and non-infected macrophages. Our results showed that the increasing glucose concentrations correlates with the low cathelicidin expression in non-infected cells, however in Mycobacterium tuberculosis infected cells, LL-37 expression was substantially increased in higher glucose concentrations, nevertheless the mycobacterial burden also increased, this phenomena can be associated with the cathelicidin immunomodulatory activity...
August 2016: Microbial Pathogenesis
Abilash Nair, Randeep Guleria, Devasenathipathy Kandasamy, Raju Sharma, Nikhil Tandon, Urvashi B Singh, Ravinder Goswami
BACKGROUND: There is limited information on prevalence of pulmonary tuberculosis (PTB) in patients with type-1-diabetes. We assessed the prevalence of PTB in patients with type-1-diabetes attending the outpatient-clinic in a tertiary-care hospital. METHODS: 151 patients with type-1-diabetes were screened for PTB by clinical examination and chest-radiography. Sputum Acid-Fast Bacilli Test (AFB) and Mycobacterium tuberculosis (M.tb) culture were performed in patients with clinical and radiological features suggestive of a possibility of PTB and also in those with history of PTB in the past...
2016: Multidisciplinary Respiratory Medicine
Yuze Li, Dianzhong Li, Jinfeng Zhang, Shurui Liu, Haijun Chen, Kun Wu
The purpose of this study is to explore why type 2 diabetes mellitus (T2DM) patients are susceptible to pulmonary tuberculosis through detection of serum Toll-like receptor 4 (TLR4), an important immune-related receptor, especially in terms of content and TLR4 gene polymorphism. Patients with T2DM complicated by pulmonary tuberculosis (T2DMTB) were selected as the case group and T2DM patients without tuberculosis were selected as the control group. Forty patients in each group were randomly selected and their serum TLR4 levels were detected and compared...
2016: Stem Cells International
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