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pulmonary tuberculosis in diabetes mellitus

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https://www.readbyqxmd.com/read/29325084/metformin-use-reverses-the-increased-mortality-associated-with-diabetes-mellitus-during-tuberculosis-treatment
#1
Nicholas R Degner, Jann-Yuan Wang, Jonathan E Golub, Petros C Karakousis
Background: The global type 2 diabetes mellitus (DM) epidemic threatens progress made in reducing tuberculosis (TB)-related mortality worldwide. Previous clinical studies have not fully evaluated potential confounding variables in addressing the impact of DM on TB treatment outcomes. The antidiabetic agent metformin regulates autophagy and may play a role as a host-directed therapeutic adjuvant to antitubercular treatment. Methods: We conducted a retrospective cohort study comprising patients aged ≥13 years undergoing treatment for culture-confirmed, drug-susceptible pulmonary TB...
January 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29297449/prevalence-of-dysglycemia-and-clinical-presentation-of-pulmonary-tuberculosis-in-western-india
#2
V Mave, S Meshram, R Lokhande, D Kadam, S Dharmshale, R Bharadwaj, A Kagal, N Pradhan, S Deshmukh, S Atre, T Sahasrabudhe, M Barthwal, S Meshram, A Kakrani, V Kulkarni, S Raskar, N Suryavanshi, R Shivakoti, S Chon, E Selvin, A Gupte, A Gupta, N Gupte, J E Golub
SETTING: Pune, India. OBJECTIVES: To estimate the prevalence and risk factors of pre-diabetes mellitus (DM) and DM, and its associations with the clinical presentation of tuberculosis (TB). DESIGN: Screening for DM was conducted among adults (age  18 years) with confirmed TB between December 2013 and January 2017. We used multinomial regression to evaluate the risk factors for pre-DM (glycated hemoglobin [HbA1c]  5.7-6.5% or fasting glucose 100-125 mg/dl) and DM (HbA1c  6...
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29207803/radiological-manifestations-of-pulmonary-tuberculosis-a-comparative-study-between-immunocompromised-and-immunocompetent-patients
#3
Manoj Mathur, Rajesh K Badhan, Sudesh Kumari, Navkiran Kaur, Saryu Gupta
Introduction: Pulmonary tuberculosis has atypical radiological manifestations in patients with underlying immunocompromised disease like diabetes and human immunodeficient virus infection. Computed tomography has important role in such patients for early diagnosis of disease and management to minimize complication. Aim: To evaluate and compare the computed tomography chest features of pulmonary tuberculosis in between immunocompromised patients and immunocompetent patients...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29168465/investigation-of-the-risk-factors-for-pulmonary-tuberculosis-a-case-control-study-among-saharia-tribe-in-gwalior-district-madhya-pradesh-india
#4
Jyothi Bhat, V G Rao, R K Sharma, M Muniyandi, Rajiv Yadav, M K Bhondley
BACKGROUND & OBJECTIVES: Prevalence of pulmonary tuberculosis (PTB) is known to be high in the indigenous tribal community Saharia in Madhya Pradesh, India. The risk factors for PTB are not well known among them. This study was done to determine various risk factors associated with PTB in the indigenous community Saharia. METHODS: A prevalence survey was conducted among Saharias of Gwalior district of Madhya Pradesh. The population surveyed was 12,123 which was the source of cases and controls for the present study...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29081342/role-of-diabetes-mellitus-on-treatment-effects-in-drug-susceptible-initial-pulmonary-tuberculosis-patients-in-china
#5
Yan Ma, Mai Ling Huang, Tao Li, Jian DU, Wei Shu, Shi Heng Xie, Hong Hong Wang, Guo Feng Zhu, Shou Yong Tan, Yan Yong Fu, Li Ping Ma, Lian Ying Zhang, Fei Ying Liu, Dai Yu Hu, Yan Ling Zhang, Xiang Qun Li, Yu Hong Liu, Liang Li
We assessed the role of diabetes mellitus (DM) on treatment effects in drug-susceptible initial pulmonary tuberculosis (PTB) patients. A prospective study was conducted in eight provinces of China from October 2008 to December 2010. We enrolled 1,313 confirmed drug-susceptible initial PTB patients, and all subjects received the treatment regimen (2H3R3E3Z3/4H3R3) as recommended by the national guidelines. Of the 1,313 PTB patients, 157 (11.9%) had DM; these patients had more sputum smear-positive rates at the end of the second month [adjusted odds ratios (aOR) 2...
September 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29062482/ocular-tuberculosis-in-hospital-universiti-sains-malaysia-a-case-series
#6
M Shahidatul-Adha, E Zunaina, A T Liza-Sharmini, W H Wan-Hazabbah, I Shatriah, I Mohtar, Y Azhany, H Adil
INTRODUCTION: Ocular tuberculosis (TB) encompasses a broad spectrum of clinical manifestations affecting different structures of the eye. It is caused by Mycobacterium tuberculosis, a great ancient organism that induces various types of diseases and unfavorable outcomes if unrecognized and not well treated. PURPOSE: To report the clinical profile of 34 ocular TB cases observed during 6 years period in Hospital Universiti Sains Malaysia (HUSM). METHOD: A retrospective review of medical records from 34 patients diagnosed with ocular TB in HUSM from January 2011 until December 2016...
December 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29029456/protein-tyrosine-phosphatase-nonreceptor-type-22-ptpn22-gene-single-nucleotide-polymorphisms-and-its-interaction-with-t2dm-on-pulmonary-tuberculosis-in-chinese-uygur-population
#7
Xian-Hua Wang, Ai-Guo Ma, Xiu-Xia Han, Lei Chen, Hui Liang, Aishan-Litifu, Abudumijit-Ablez, Feng Xue
AIMS: To investigate the association of several single nucleotide polymorphisms (SNPs) within Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene and additional gene- gene and gene- type 2 diabetes mellitus (T2DM) interaction with pulmonary tuberculosis (PTB) risk in Chinese Uygur population. METHODS: A total of 722 participants (186 males, 536 females) were selected, including 360 PTB patients and 362 control participants. Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and T2DM...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28951414/vitamin-d-status-in-tuberculosis-patients-with-diabetes-prediabetes-and-normal-blood-glucose-in-china-a-cross-sectional-study
#8
Xin Zhao, Yanli Yuan, Yan Lin, Tiejuan Zhang, Jianjun Ma, Wanli Kang, Yunlong Bai, Yunlong Wang, Hongshan Shao, Riitta A Dlodlo, Anthony D Harries
OBJECTIVE: The association between tuberculosis (TB), diabetes mellitus (DM) and vitamin D status is poorly characterised. We therefore: (1) determined vitamin D status in patients with TB in relation to whether they had normal fasting blood glucose (FBG), pre-DM or DM and (2) assessed whether baseline characteristics in patients with TB, including their DM status, were associated with vitamin D deficiency. METHODS: In patients with TB consecutively attending six clinics or hospitals in China, we measured 25-hydroxycholecalciferol (25-(OH)D3) at the time of registration using electrochemiluminescence in a COBASE 601 Roche analyser by chemiluminescence immunoassay...
September 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28934668/diabetes-mellitus-increased-all-cause-mortality-rate-among-newly-diagnosed-tuberculosis-patients-in-an-asian-population-a-nationwide-population-based-study
#9
Po-Yen Ko, Shi-Dou Lin, Ming-Chia Hsieh, Yu-Cheng Chen
AIMS: To investigate the effect of diabetes mellitus (DM) on all-cause mortality among patients with newly-diagnosed tuberculosis (TB) in an Asian population. We also identified risk factors for mortality in these patients. METHODS: The data were obtained from the National Health Insurance Research Database and included 9831 newly-diagnosed TB individuals and 1627 TB mortality cases in the period of 2000-2010. The mortality data were divided into a DM group and a non-DM group...
November 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28919116/global-regional-and-national-age-sex-specific-mortality-for-264-causes-of-death-1980-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#10
(no author information available yet)
BACKGROUND: Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specific mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends. METHODS: We estimated cause-specific deaths and years of life lost (YLLs) by age, sex, geography, and year...
September 16, 2017: Lancet
https://www.readbyqxmd.com/read/28902922/molecular-clustering-of-patients-with-diabetes-and-pulmonary-tuberculosis-a-systematic-review-and-meta-analysis
#11
REVIEW
Francles Blanco-Guillot, Guadalupe Delgado-Sánchez, Norma Mongua-Rodríguez, Pablo Cruz-Hervert, Leticia Ferreyra-Reyes, Elizabeth Ferreira-Guerrero, Mercedes Yanes-Lane, Rogelio Montero-Campos, Miriam Bobadilla-Del-Valle, Pedro Torres-González, Alfredo Ponce-de-León, José Sifuentes-Osornio, Lourdes Garcia-Garcia
INTRODUCTION: Many studies have explored the relationship between diabetes mellitus (DM) and tuberculosis (TB) demonstrating increased risk of TB among patients with DM and poor prognosis of patients suffering from the association of DM/TB. Owing to a paucity of studies addressing this question, it remains unclear whether patients with DM and TB are more likely than TB patients without DM to be grouped into molecular clusters defined according to the genotype of the infecting Mycobacterium tuberculosis bacillus...
2017: PloS One
https://www.readbyqxmd.com/read/28862176/index-tb-guidelines-guidelines-on-extrapulmonary-tuberculosis-for-india
#12
Surendra K Sharma, H Ryan, Sunil Khaparde, K S Sachdeva, Achintya D Singh, Alladi Mohan, Rohit Sarin, C N Paramasivan, Prahlad Kumar, Neeraj Nischal, Saurav Khatiwada, Paul Garner, Prathap Tharyan
Extrapulmonary tuberculosis (EPTB) is frequently a diagnostic and therapeutic challenge. It is a common opportunistic infection in people living with HIV/AIDS and other immunocompromised states such as diabetes mellitus and malnutrition. There is a paucity of data from clinical trials in EPTB and most of the information regarding diagnosis and management is extrapolated from pulmonary TB. Further, there are no formal national or international guidelines on EPTB. To address these concerns, Indian EPTB guidelines were developed under the auspices of Central TB Division and Directorate of Health Services, Ministry of Health and Family Welfare, Government of India...
April 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28852602/the-importance-of-a-complete-differential-case-report-of-a-tuberculoma-in-a-patient-without-pulmonary-involvement
#13
Pooja Sethi, Jennifer Treece, Chidinma Onweni, Vandana Pai, Zia Rahman, Siddharth Singh
Patients with a tuberculoma typically present with pulmonary involvement of tuberculosis and have risk factors for tuberculosis (TB). The risk factors for tuberculosis include bacillary load, proximity to infectious case, immunosuppressive conditions, malnutrition, young age, diabetes mellitus, working in healthcare, recent incarceration, alcohol use, and tobacco use. Although rare, it is possible for a patient to present with a tuberculoma despite the absence of risk factors for tuberculosis other than diabetes and without pulmonary involvement...
June 28, 2017: Curēus
https://www.readbyqxmd.com/read/28747581/protein-tyrosine-phosphatase-nonreceptor-type-22-ptpn22-gene-single-nucleotide-polymorphisms-and-its-interaction-with-t2dm-on-pulmonary-tuberculosis-in-chinese-uygur-population
#14
Xian-Hua Wang, Ai-Guo Ma, Xiu-Xia Han, Lei Chen, Hui Liang, Aishan-Litifu, Abudumijit-Ablez, Feng Xue
AIMS: To investigate the association of several single nucleotide polymorphisms (SNPs) within Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene and additional gene- gene and gene- type 2 diabetes mellitus (T2DM) interaction with pulmonary tuberculosis (PTB) risk in Chinese Uygur population. METHODS: A total of 722 participants (186 males, 536 females) were selected, including 360 PTB patients and 362 control participants. Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and T2DM...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28696520/delays-in-presentation-and-diagnosis-of-pulmonary-tuberculosis-a-retrospective-study-of-a-tertiary-health-service-in-western-melbourne-2011-2014
#15
Eloise Williams, Allen Cheng, Garry P Lane, Stephen David Guy
BACKGROUND: Effective tuberculosis (TB) control relies on early diagnosis and prompt treatment commencement. AIM: To investigate delays in presentation and diagnosis of pulmonary TB (PTB) in a low incidence setting in western Melbourne. METHODS: A single-centered retrospective observational cohort study of symptomatic patients ≥ 18 years newly diagnosed with PTB that were commenced on treatment between 1(st) December 2011 and 1(st) December 2014 at a tertiary teaching hospital in western Melbourne...
July 11, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28670542/a-study-of-the-patients-suffering-from-tuberculosis-and-tuberculosis-diabetes-comorbidity-in-revised-national-tuberculosis-control-program-centers-of-northern-madhya-pradesh-india
#16
Anil Kumar Agarwal, Ginisha Gupta, Priyesh Marskole, Anju Agarwal
BACKGROUND: Diabetes mellitus (DM) is recognized as an important risk factor to tuberculosis (TB). India has high TB burden, along with rising DM prevalence. AIM: This study was conducted to document the coexistence of DM and TB in persons with established TB under the Revised National Tuberculosis Control Program. TYPE OF STUDY: This was a cross-sectional, descriptive observational study conducted at selected Directly Observed Therapy center in Gwalior North Central India...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28652186/il-6-and-il-18-cytokine-gene-variants-of-pulmonary-tuberculosis-patients-with-co-morbid-diabetes-mellitus-and-their-household-contacts-in-hyderabad
#17
Meenakshi Ponnana, Ramya Sivangala, Lavanya Joshi, Vijayalakshmi Valluri, Sumanlatha Gaddam
PURPOSE: Association of cytokine genes reflects their susceptibility towards infection and disease in household contacts (HHC) of pulmonary tuberculosis (PTB) patients. Hyperglycemia, a common factor in diabetics might influence their risk towards mycobacterium tuberculosis infection and disease development. This study determines the association of IL-6 and IL-18 cytokine gene variants of TB patients with diabetes mellitus (TBDM) and their HHC in Hyderabad. METHODS: Single nucleotide polymorphisms of IL-6 (-174 G>C and -572 G>C) and IL-18 (-137 G>C and -607 C>A) cytokine genes were genotyped by Amplification Refractory Mutation System and Restriction Fragment Length polymerase chain reaction in total of 705 subjects comprising of TBDM, their HHC, PTB, DM and Healthy controls (HC)...
September 5, 2017: Gene
https://www.readbyqxmd.com/read/28628646/the-impact-of-glycemic-status-on-radiological-manifestations-of-pulmonary-tuberculosis-in-diabetic-patients
#18
Li-Kuo Huang, Hsueh-Han Wang, Yi-Chun Lai, Shi-Chuan Chang
SETTING: Diabetes mellitus (DM) may increase risk of pulmonary tuberculosis (PTB) and influence its radiological manifestations. OBJECTIVE: To evaluate the impact of glycemic status on radiological findings of PTB in diabetic patients. METHODS: Between January 2010 and December 2015, chest radiographs (CXRs) in consecutive 214 DM patients with culture-proved PTB and 123 available thoracic computed tomography (CT) scans were enrolled. An equal number of non-DM patients with similar demographics was included as the control group...
2017: PloS One
https://www.readbyqxmd.com/read/28543817/influence-of-diabetes-mellitus-on-immunity-to-human-tuberculosis
#19
REVIEW
Pavan Kumar Nathella, Subash Babu
Type 2 diabetes mellitus(DM) is a major risk factor for the development of active pulmonary tuberculosis (TB), with development of DM pandemic in countries where TB is also endemic. Understanding the impact of DM on TB and the determinants of co-morbidity is essential in responding to this growing public health problem with improved therapeutic approaches. Despite the clinical and public health significance posed by the dual burden of TB and DM, little is known about the immunological and biochemical mechanisms of susceptibility...
September 2017: Immunology
https://www.readbyqxmd.com/read/28480422/bioactive-components-of-gynura-divaricata-and-its-potential-use-in-health-food-and-medicine-a-mini-review
#20
REVIEW
Bing-Qing Xu, Yu-Qing Zhang
BACKGROUND: G. divaricata (L.) DC belongs to genus the Gynura Cass which is a kind of perennial herb that has good health protection efficacy and is especially used widely in medicine and functional food. It is one of the most famous traditional Chinese medicinal herbs and is usually used to cure bronchitis, pulmonary tuberculosis, kink cough, rheumatism, diabetes, and so on. It has a long history for the treatment of diabetes mellitus in the folk medicine. This review is aimed at gathering all information relating to G...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
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