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pulmonary tuberculosis in diabetes mellitus

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https://www.readbyqxmd.com/read/28747581/protein-tyrosine-phosphatase-nonreceptor-type-22-ptpn22-gene-single-nucleotide-polymorphisms-and-its-interaction-with-t2dm-on-pulmonary-tuberculosis-in-chinese-uygur-population
#1
Xian-Hua Wang, Ai-Guo Ma, Xiu-Xia Han, Lei Chen, Hui Liang, Aishan-Litifu, Abudumijit-Ablez, Feng Xue
AIMS: To investigate the association of several single nucleotide polymorphisms (SNPs) within Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene and additional gene- gene and gene- type 2 diabetes mellitus (T2DM) interaction with pulmonary tuberculosis (PTB) risk in Chinese Uygur population. METHODS: A total of 722 participants (186 males, 536 females) were selected, including 360 PTB patients and 362 control participants. Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and T2DM...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28696520/delays-in-presentation-and-diagnosis-of-pulmonary-tuberculosis-a-retrospective-study-of-a-tertiary-health-service-in-western-melbourne-2011-2014
#2
Eloise Williams, Allen Cheng, Garry P Lane, Stephen David Guy
BACKGROUND: Effective tuberculosis (TB) control relies on early diagnosis and prompt treatment commencement. AIM: To investigate delays in presentation and diagnosis of pulmonary TB (PTB) in a low incidence setting in western Melbourne. METHODS: A single-centered retrospective observational cohort study of symptomatic patients ≥ 18 years newly diagnosed with PTB that were commenced on treatment between 1(st) December 2011 and 1(st) December 2014 at a tertiary teaching hospital in western Melbourne...
July 11, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28670542/a-study-of-the-patients-suffering-from-tuberculosis-and-tuberculosis-diabetes-comorbidity-in-revised-national-tuberculosis-control-program-centers-of-northern-madhya-pradesh-india
#3
Anil Kumar Agarwal, Ginisha Gupta, Priyesh Marskole, Anju Agarwal
BACKGROUND: Diabetes mellitus (DM) is recognized as an important risk factor to tuberculosis (TB). India has high TB burden, along with rising DM prevalence. AIM: This study was conducted to document the coexistence of DM and TB in persons with established TB under the Revised National Tuberculosis Control Program. TYPE OF STUDY: This was a cross-sectional, descriptive observational study conducted at selected Directly Observed Therapy center in Gwalior North Central India...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28652186/il-6-and-il-18-cytokine-gene-variants-of-pulmonary-tuberculosis-patients-with-co-morbid-diabetes-mellitus-and-their-household-contacts-in-hyderabad
#4
Meenakshi Ponnana, Ramya Sivangala, Lavanya Joshi, Vijayalakshmi Valluri, Sumanlatha Gaddam
PURPOSE: Association of cytokine genes reflects their susceptibility towards infection and disease in household contacts (HHC) of pulmonary tuberculosis (PTB) patients. Hyperglycemia, a common factor in diabetics might influence their risk towards mycobacterium tuberculosis infection and disease development. This study determines the association of IL-6 and IL-18 cytokine gene variants of TB patients with diabetes mellitus (TBDM) and their HHC in Hyderabad. METHODS: Single nucleotide polymorphisms of IL-6 (-174 G>C and -572 G>C) and IL-18 (-137 G>C and -607 C>A) cytokine genes were genotyped by Amplification Refractory Mutation System and Restriction Fragment Length polymerase chain reaction in total of 705 subjects comprising of TBDM, their HHC, PTB, DM and Healthy controls (HC)...
June 23, 2017: Gene
https://www.readbyqxmd.com/read/28628646/the-impact-of-glycemic-status-on-radiological-manifestations-of-pulmonary-tuberculosis-in-diabetic-patients
#5
Li-Kuo Huang, Hsueh-Han Wang, Yi-Chun Lai, Shi-Chuan Chang
SETTING: Diabetes mellitus (DM) may increase risk of pulmonary tuberculosis (PTB) and influence its radiological manifestations. OBJECTIVE: To evaluate the impact of glycemic status on radiological findings of PTB in diabetic patients. METHODS: Between January 2010 and December 2015, chest radiographs (CXRs) in consecutive 214 DM patients with culture-proved PTB and 123 available thoracic computed tomography (CT) scans were enrolled. An equal number of non-DM patients with similar demographics was included as the control group...
2017: PloS One
https://www.readbyqxmd.com/read/28543817/influence-of-diabetes-mellitus-on-immunity-to-human-tuberculosis
#6
REVIEW
Pavan Kumar Nathella, Subash Babu
Type 2 diabetes mellitus(DM) is a major risk factor for the development of active pulmonary tuberculosis (TB), with development of DM pandemic in countries where TB is also endemic. Understanding the impact of DM on TB and the determinants of co-morbidity is essential in responding to this growing public health problem with improved therapeutic approaches. Despite the clinical and public health significance posed by the dual burden of TB and DM, little is known about the immunological and biochemical mechanisms of susceptibility...
September 2017: Immunology
https://www.readbyqxmd.com/read/28480422/bioactive-components-of-gynura-divaricata-and-its-potential-use-in-health-food-and-medicine-a-mini-review
#7
REVIEW
Bing-Qing Xu, Yu-Qing Zhang
BACKGROUND: G. divaricata (L.) DC belongs to genus the Gynura Cass which is a kind of perennial herb that has good health protection efficacy and is especially used widely in medicine and functional food. It is one of the most famous traditional Chinese medicinal herbs and is usually used to cure bronchitis, pulmonary tuberculosis, kink cough, rheumatism, diabetes, and so on. It has a long history for the treatment of diabetes mellitus in the folk medicine. This review is aimed at gathering all information relating to G...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28412726/inhaled-corticosteroids-have-a-protective-effect-against-lung-cancer-in-female-patients-with-chronic-obstructive-pulmonary-disease-a-nationwide-population-based-cohort-study
#8
Shih-Feng Liu, Ho-Chang Kuo, Meng-Chih Lin, Shu-Chen Ho, Mei-Lien Tu, Yu-Mu Chen, Yung-Che Chen, Wen-Feng Fang, Chin-Chou Wang, Guan-Heng Liu
Whether the use of inhaled corticosteroids (ICS) protects patients with chronic obstructive pulmonary disease (COPD) from lung cancer remains undetermined. In this retrospective nationwide population-based cohort study, we extracted data of 13,686 female COPD patients (ICS users, n = 1,290, ICS non-users, n = 12,396) diagnosed between 1997 and 2009 from the Taiwan's National Health Insurance database. These patients were followed-up until 2011, and lung cancer incidence was determined. Cox regression analysis was used to estimate hazard ratios (HRs) for lung cancer incidence...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28360440/effect-of-poor-glycemic-control-in-newly-diagnosed-patients-with-smear-positive-pulmonary-tuberculosis-and-type-2-diabetes-mellitus
#9
Vinay Mahishale, Sindhuri Avuthu, Bhagyashri Patil, Mitchelle Lolly, Ajith Eti, Sujeer Khan
BACKGROUND: There is growing evidence that diabetes mellitus (DM) is an important risk factor for tuberculosis (TB). A significant number of DM patients have poor glycemic control. This study was carried out to find the impact of poor glycemic control on newly diagnosed smear-positive pulmonary tuberculosis patients with type-2 diabetes mellitus in a tertiary care hospital. METHODS: In a hospital-based prospective study, newly diagnosed smear-positive pulmonary TB with DM patients were classified as poorly controlled diabetes (HBA1C≥7%) and optimal control diabetics (HbA1c<7%)...
March 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28317813/association-between-pulmonary-tuberculosis-and-type-2-diabetes-in-sudanese-patients
#10
Mona Ahmed, Ibtihal Omer, Sannaa M A Osman, Eltayib H Ahmed-Abakur
INTRODUCTION: Tuberculosis (TB) and diabetes mellitus (DM) are both important health issues, and the association between DM and TB may be the next challenge for global TB control worldwide, type 2 DM (T2DM) responsible for 90% of DM cases. Persons with diabetes have a significantly increased risk of active TB, which is two to three times higher than in persons without diabetes. The aim of this study was to determine the association between pulmonary tuberculosis (PTB) and T2DM among Sudanese patients and also to determine the association between hemoglobin A1c (HbA1c) percentage in diabetic patients and development of PTB and effect of duration of T2DM in developing PTB...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28275494/chronic-pulmonary-mucormycosis-an-emerging-fungal-infection-in-diabetes-mellitus
#11
Nousheen Iqbal, Muhammad Irfan, Kauser Jabeen, Murtaza Mohammed Kazmi, Muhammad Usman Tariq
Mucormycosis commonly affects immunocompromised individuals with defects in neutrophil function or count. Diabetes mellitus is an important risk factor due to impair innate and acquired immunity for mucormycosis, with rhino-orbital-cerebral involvement as a common presentation. Pulmonary mucormycosis (PM) although a rare presentation in diabetic patients but is associated with high mortality and morbidity. An early diagnosis of PM is difficult, due to rarity of the disease and clinical and radiological features resembling tuberculosis (TB) which is common in Pakistan...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28245792/association-between-body-mass-index-and-diabetes-mellitus-in-tuberculosis-patients-in-china-a-community-based-cross-sectional-study
#12
Jing Cai, Aiguo Ma, Qiuzhen Wang, Xiuxia Han, Shanliang Zhao, Yu Wang, Evert G Schouten, Frans J Kok
BACKGROUND: We planned to determine the association of body mass index (BMI) with diabetes mellitus (DM) and impaired fasting glucose (IFG) in Chinese pulmonary tuberculosis (PTB) patients. METHODS: 3,505 newly-diagnosed PTB patients registered in PTB clinics in Linyi of China between September 2010 and March 2013 were enrolled. DM and IFG were identified based on fasting plasma glucose levels. ROC analysis was used to predict the ability of screening of BMI for DM and IFG in PTB patients...
February 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28245710/diabetes-and-pulmonary-tuberculosis-a-global-overview-with-special-focus-on-the-situation-in-asian-countries-with-high-tb-dm-burden
#13
Chunlan Zheng, Minhui Hu, Feng Gao
BACKGROUND: The double burden of tuberculosis (TB) and diabetes mellitus (DM) is hitting certain Asian countries harder than other areas. In a global estimate, 15% of all TB cases could be attributable to DM, with 40% of those cases coming from India and China. Many other countries of South, East, and South-East Asia are of particular concern given their TB burdens, large projected increases in DM prevalence, and population size. OBJECTIVE: In this narrative review, we aimed to: (i) give an overall insight into the evidence on TB-DM epidemiology from high double burden Asian countries, (ii) present the evidence on bi-directional screening implementation in this region, (iii) discuss possible factors related to higher TB susceptibility of Asian diabetic patients, and (iv) identify TB-DM comorbidity treatment challenges...
2017: Global Health Action
https://www.readbyqxmd.com/read/28244689/effects-of-diabetes-mellitus-on-the-clinical-presentation-and-treatment-response-in-tuberculosis
#14
Chi C Leung, Wing W Yew, Thomas Y W Mok, Kam S Lau, Chi F Wong, Chi H Chau, Chi K Chan, Kwok C Chang, Greta Tam, Cheuk M Tam
BACKGROUND AND OBJECTIVE: With the colliding global epidemics of diabetes mellitus (DM) and tuberculosis (TB), we studied the effects of DM on the presentation of TB and its response to treatment. METHODS: Consecutive TB patients from 2006 to 2010 in a territory-wide treatment programme offering 9-month extended treatment for TB patients with DM were examined and followed up prospectively to assess their treatment response. Successful treatment completers were tracked through the TB registry and death registry for relapse, death or till 31 December 2014, whichever was the earliest...
August 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28185999/ct-findings-of-pulmonary-tuberculosis-and-tuberculous-pleurisy-in-diabetes-mellitus-patients
#15
Jihyun Kim, In Jae Lee, Joo Hee Kim
PURPOSE: We aimed to assess computed tomography (CT) findings of pulmonary tuberculosis (TB) and TB pleurisy in diabetes mellitus (DM) patients and to evaluate the effect of duration of DM on radiologic findings of pulmonary TB and TB pleurisy. METHODS: Ninety-three consecutive patients diagnosed as active pulmonary TB with underlying DM were enrolled in our study. As a control group, 100 pulmonary TB patients without DM were randomly selected. TB patients with DM were subdivided into two subgroups depending on diabetes duration of ≥10 years or <10 years...
March 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28184994/prevalence-and-impact-of-diabetes-mellitus-among-patients-with-active-pulmonary-tuberculosis-in-south-korea
#16
Eun Hye Lee, Jung Mo Lee, Young Ae Kang, Ah Young Leem, Eun Young Kim, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Song Yee Kim
OBJECTIVE: South Korea has an increasing prevalence of diabetes and a relatively high burden of tuberculosis. We aimed to determine the prevalence of diabetes in patients with active pulmonary tuberculosis (PTB) and examine the effect of diabetes on tuberculosis treatment outcomes. SETTING AND DESIGN: Data from patients ≥30 years diagnosed with and treated for PTB between January 2010 and December 2012 at Severance Hospital, a 2000-bed tertiary referral hospital in Seoul, South Korea, were analyzed and compared with data from a contemporaneous general population sample extracted from KNHANES V...
February 9, 2017: Lung
https://www.readbyqxmd.com/read/28127232/computed-tomography-findings-of-pulmonary-mycobacterium-simiae-infection
#17
Ayeh Baghizadeh, Payam Mehrian, Poopak Farnia
Nontuberculous mycobacterial (NTM) pulmonary infections can be quite similar to tuberculosis, both clinically and radiologically. However, the treatment protocol is not similar. Mycobacterium simiae is a rare cause of NTM pulmonary infection. Herein, we aimed to evaluate and compare the computed tomography (CT) scan findings of M. simiae infection in lungs. For this reason, thirty-four patients (n = 34) with M. simiae lung infection were retrospectively evaluated. Diagnosis was confirmed by American Thoracic Society (ATS) guidelines and CT scans were reviewed in both lung and mediastinal windows...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28089216/diabetes-is-associated-with-severe-adverse-events-in-multidrug-resistant-tuberculosis
#18
Marcela Muñoz-Torrico, José Caminero-Luna, Giovanni Battista Migliori, Lia D'Ambrosio, José Luis Carrillo-Alduenda, Héctor Villareal-Velarde, Alfredo Torres-Cruz, Héctor Flores-Vergara, Dina Martínez-Mendoza, Cecilia García-Sancho, Rosella Centis, Miguel Ángel Salazar-Lezama, Rogelio Pérez-Padilla
INTRODUCTION: Diabetes mellitus (DM), a very common disease in Mexico, is a well-known risk factor for tuberculosis (TB). However, it is not known by which extent DM predisposes to adverse events (AE) to anti-TB drugs and/or to worse outcomes in patients with multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB). The main objective of this study was to describe the outcomes of TB treatment, the impact of DM and the prevalence of AE in a cohort of patients with MDR-/XDR pulmonary TB treated at the national TB referral centre in Mexico City...
May 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27919230/the-association-of-hyperglycaemia-with-prevalent-tuberculosis-a-population-based-cross-sectional-study
#19
Sarah Lou Bailey, Helen Ayles, Nulda Beyers, Peter Godfrey-Faussett, Monde Muyoyeta, Elizabeth du Toit, John S Yudkin, Sian Floyd
BACKGROUND: Systematic reviews suggest that the incidence of diagnosed tuberculosis is two- to- three times higher in those with diabetes mellitus than in those without. Few studies have previously reported the association between diabetes or hyperglycaemia and the prevalence of active tuberculosis and none in a population-based study with microbiologically-defined tuberculosis. Most have instead concentrated on cases of diagnosed tuberculosis that present to health facilities. We had the opportunity to measure glycaemia alongside prevalent tuberculosis...
December 5, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27891359/diabetes-mellitus-among-newly-diagnosed-tuberculosis-patients-in-tribal-odisha-an-exploratory-study
#20
Magna Manjareeka, Subrata Kumar Palo, Subhashisa Swain, Sandipana Pati, Sanghamitra Pati
INTRODUCTION: The association between Diabetes Mellitus (DM) and Tuberculosis (TB) poses a strong public health challenge. Tribal ethnics possess a different propensity towards infectious and haematological diseases which may influence the inter-relationship of DM and TB and thus merit separate attention. AIM: To investigate the prevalence of diabetes in newly diagnosed pulmonary TB patients of tribal ethnicity in Odisha. MATERIALS AND METHODS: A cross-sectional study was carried out over a period of 9 months at four designated TB microscopic centres in a tribal district (Malkangiri) of Odisha...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
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