C Moggi, G Memmini, M Turini, L Ciulli
At the moment it is assumed that each strongly aggressive pathogenic agent, such as bacteria, viruses, toins, trauma, burns, grave asphyxia, allergic agents, and so on, could trigger serious and uncontrollable inflammatory response. That is due to an excessive response of subject's immune system, through the dysregulation of pro-inflammatory cytokines release. The initial physiopathological event of inflammatory response consists in the production of "primary cytokines", TNF-alpha, IL-1 and IL-6 by macrophages...
July 1996: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics