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https://www.readbyqxmd.com/read/27689881/the-insulin-like-proteins-dilps-2-5-determine-diapause-inducibility-in-drosophila
#1
Luca Schiesari, Gabriele Andreatta, Charalambos P Kyriacou, Michael B O'Connor, Rodolfo Costa
Diapause is an actively induced dormancy that has evolved in Metazoa to resist environmental stresses. In temperate regions, many diapausing insects overwinter at low temperatures by blocking embryonic, larval or adult development. Despite its Afro-tropical origin, Drosophila melanogaster migrated to temperate regions of Asia and Europe where females overwinter as adults by arresting gonadal development (reproductive diapause) at temperatures <13°C. Recent work in D. melanogaster has implicated the developmental hormones dILPs-2 and/or dILP3, and dILP5, homologues of vertebrate insulin/insulin-like growth factors (IGFs), in reproductive arrest...
2016: PloS One
https://www.readbyqxmd.com/read/27260305/developmental-and-cell-cycle-quiescence-is-mediated-by-the-nuclear-hormone-receptor-coregulator-din-1s-in-the-caenorhabditis-elegans-dauer-larva
#2
Eileen Colella, Shaolin Li, Richard Roy
When faced with suboptimal growth conditions, Caenorhabditis elegans larvae can enter a diapause-like stage called "dauer" that is specialized for dispersal and survival. The decision to form a dauer larva is controlled by three parallel signaling pathways, whereby a compromise of TGFβ, cyclic guanosine monophosphate, or insulin/IGF-like signaling (ILS) results in dauer formation. Signals from these pathways converge on DAF-12, a nuclear hormone receptor that triggers the changes required to initiate dauer formation...
August 2016: Genetics
https://www.readbyqxmd.com/read/26838180/diapause-is-associated-with-a-change-in-the-polarity-of-secretion-of-insulin-like-peptides
#3
Yohei Matsunaga, Yoko Honda, Shuji Honda, Takashi Iwasaki, Hiroshi Qadota, Guy M Benian, Tsuyoshi Kawano
The insulin/IGF-1 signalling (IIS) pathway plays an important role in the regulation of larval diapause, the long-lived growth arrest state called dauer arrest, in Caenorhabditis elegans. In this nematode, 40 insulin-like peptides (ILPs) have been identified as putative ligands of the IIS pathway; however, it remains unknown how ILPs modulate larval diapause. Here we show that the secretory polarity of INS-35 and INS-7, which suppress larval diapause, is changed in the intestinal epithelial cells at larval diapause...
February 3, 2016: Nature Communications
https://www.readbyqxmd.com/read/26656736/dbl-1-tgf-%C3%AE-and-daf-12-nhr-signaling-mediate-cell-nonautonomous-effects-of-daf-16-foxo-on-starvation-induced-developmental-arrest
#4
Rebecca E W Kaplan, Yutao Chen, Brad T Moore, James M Jordan, Colin S Maxwell, Adam J Schindler, L Ryan Baugh
Nutrient availability has profound influence on development. In the nematode C. elegans, nutrient availability governs post-embryonic development. L1-stage larvae remain in a state of developmental arrest after hatching until they feed. This "L1 arrest" (or "L1 diapause") is associated with increased stress resistance, supporting starvation survival. Loss of the transcription factor daf-16/FOXO, an effector of insulin/IGF signaling, results in arrest-defective and starvation-sensitive phenotypes. We show that daf-16/FOXO regulates L1 arrest cell-nonautonomously, suggesting that insulin/IGF signaling regulates at least one additional signaling pathway...
December 2015: PLoS Genetics
https://www.readbyqxmd.com/read/26435887/new-links-between-protein-n-terminal-acetylation-dauer-diapause-and-the-insulin-igf-1-signaling-pathway-in-caenorhabditis-elegans
#5
Kurt Warnhoff, Kerry Kornfeld
Protein N-terminal acetylation is a widespread posttranslational modification in eukaryotes that is catalyzed by N-terminal acetyltransferases (NATs). The biochemical activity of NATs has been characterized extensively, whereas the biological function of NATs is only beginning to be defined. Here we comment on recent progress in understanding the function of NAT activity in C. elegans based on the characterization of natc-1 by Warnhoff et al. (2014) and daf-31 by Chen et al. (2014).(1,2) natc-1 encodes an auxiliary subunit of the NatC complex and modulates stress tolerance, dauer entry, and adult lifespan...
April 2015: Worm
https://www.readbyqxmd.com/read/25830239/co-chaperone-p23-regulates-c-elegans-lifespan-in-response-to-temperature
#6
Makoto Horikawa, Surojit Sural, Ao-Lin Hsu, Adam Antebi
Temperature potently modulates various physiologic processes including organismal motility, growth rate, reproduction, and ageing. In ectotherms, longevity varies inversely with temperature, with animals living shorter at higher temperatures. Thermal effects on lifespan and other processes are ascribed to passive changes in metabolic rate, but recent evidence also suggests a regulated process. Here, we demonstrate that in response to temperature, daf-41/ZC395.10, the C. elegans homolog of p23 co-chaperone/prostaglandin E synthase-3, governs entry into the long-lived dauer diapause and regulates adult lifespan...
April 2015: PLoS Genetics
https://www.readbyqxmd.com/read/25517099/dauer-independent-insulin-igf-1-signalling-implicates-collagen-remodelling-in-longevity
#7
Collin Y Ewald, Jess N Landis, Jess Porter Abate, Coleen T Murphy, T Keith Blackwell
Interventions that delay ageing mobilize mechanisms that protect and repair cellular components, but it is unknown how these interventions might slow the functional decline of extracellular matrices, which are also damaged during ageing. Reduced insulin/IGF-1 signalling (rIIS) extends lifespan across the evolutionary spectrum, and in juvenile Caenorhabditis elegans also allows the transcription factor DAF-16/FOXO to induce development into dauer, a diapause that withstands harsh conditions. It has been suggested that rIIS delays C...
March 5, 2015: Nature
https://www.readbyqxmd.com/read/25058511/hc-fau-a-novel-gene-regulating-diapause-in-the-nematode-parasite-haemonchus-contortus
#8
Baolong Yan, Xiaolu Guo, Qianjin Zhou, Yi Yang, Xueqiu Chen, Weiwei Sun, Aifang Du
Diapause induced in the early fourth stage of Haemonchus contortus is a strategy to adapt this nematode to hostile environmental conditions. In this study, we identified a new gene, Hc-fau, a homologue of human fau and Caenorhabditis elegans Ce-rps30. Hc-fau encodes two proteins through alternative RNA splicing, Hc-FAUA and Hc-FAUB, consisting of 130 and 107 amino acids, respectively. Hc-FAU possesses a diverged ubiquitin-like (UBiL) protein domain and a conserved ribosome protein S30 domain. The protein is ubiquitously expressed, except in the gonad...
October 1, 2014: International Journal for Parasitology
https://www.readbyqxmd.com/read/24062693/factors-that-regulate-insulin-producing-cells-and-their-output-in-drosophila
#9
REVIEW
Dick R Nässel, Olga I Kubrak, Yiting Liu, Jiangnan Luo, Oleh V Lushchak
Insulin-like peptides (ILPs) and growth factors (IGFs) not only regulate development, growth, reproduction, metabolism, stress resistance, and lifespan, but also certain behaviors and cognitive functions. ILPs, IGFs, their tyrosine kinase receptors and downstream signaling components have been largely conserved over animal evolution. Eight ILPs have been identified in Drosophila (DILP1-8) and they display cell and stage-specific expression patterns. Only one insulin receptor, dInR, is known in Drosophila and most other invertebrates...
2013: Frontiers in Physiology
https://www.readbyqxmd.com/read/23664972/the-tumor-suppressor-rb-critically-regulates-starvation-induced-stress-response-in-c-elegans
#10
Mingxue Cui, Max L Cohen, Cindy Teng, Min Han
How animals coordinate gene expression in response to starvation is an outstanding problem closely linked to aging, obesity, and cancer. Newly hatched Caenorhabditis elegans respond to food deprivation by halting development and promoting long-term survival (L1 diapause), thereby providing an excellent model for the study of starvation response. Through a genetic search, we have discovered that the tumor suppressor Rb critically promotes survival during L1 diapause and most likely does so by regulating the expression of genes in both insulin-IGF-1 signaling (IIS)-dependent and -independent pathways mainly in neurons and the intestine...
June 3, 2013: Current Biology: CB
https://www.readbyqxmd.com/read/23644454/the-microrna-mir-235-couples-blast-cell-quiescence-to-the-nutritional-state
#11
Hidefumi Kasuga, Masamitsu Fukuyama, Aya Kitazawa, Kenji Kontani, Toshiaki Katada
The coordination of stem- and blast-cell behaviours, such as self-renewal, differentiation and quiescence, with physiological changes underlies growth, regeneration and tissue homeostasis. Germline stem and somatic blast cells in newly hatched Caenorhabditis elegans larvae can suspend postembryonic development, which consists of diverse cellular events such as migration, proliferation and differentiation, until the nutritional state becomes favourable (termed L1 diapause). Although previous studies showed that the insulin/insulin-like growth factor (IGF) signalling (IIS) pathway regulates this developmental quiescence, the detailed mechanism by which the IIS pathway enables these multipotent cells to respond to nutrient availability is unknown...
May 23, 2013: Nature
https://www.readbyqxmd.com/read/23300463/diapause-formation-and-downregulation-of-insulin-like-signaling-via-daf-16-foxo-delays-axonal-degeneration-and-neuronal-loss
#12
Andrea Calixto, Juan S Jara, Felipe A Court
Axonal degeneration is a key event in the pathogenesis of neurodegenerative conditions. We show here that mec-4d triggered axonal degeneration of Caenorhabditis elegans neurons and mammalian axons share mechanistical similarities, as both are rescued by inhibition of calcium increase, mitochondrial dysfunction, and NMNAT overexpression. We then explore whether reactive oxygen species (ROS) participate in axonal degeneration and neuronal demise. C. elegans dauers have enhanced anti-ROS systems, and dauer mec-4d worms are completely protected from axonal degeneration and neuronal loss...
2012: PLoS Genetics
https://www.readbyqxmd.com/read/22872476/physiological-control-of-germline-development
#13
REVIEW
E Jane Albert Hubbard, Dorota Z Korta, Diana Dalfó
The intersection between developmental programs and environmental conditions that alter physiology is a growing area of research interest. The C. elegans germ line is emerging as a particularly sensitive and powerful model for these studies. The germ line is subject to environmentally regulated diapause points that allow worms to withstand harsh conditions both prior to and after reproduction commences. It also responds to more subtle changes in physiological conditions. Recent studies demonstrate that different aspects of germ line development are sensitive to environmental and physiological changes and that conserved signaling pathways such as the AMPK, Insulin/IGF, TGFβ, and TOR-S6K, and nuclear hormone receptor pathways mediate this sensitivity...
2013: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/22683638/physiological-function-expression-pattern-and-transcriptional-regulation-of-a-caenorhabditis-elegans-insulin-like-peptide-ins-18
#14
Yohei Matsunaga, Keiko Gengyo-Ando, Shohei Mitani, Takashi Iwasaki, Tsuyoshi Kawano
In Caenorhabditis elegans, insulin/insulin-like growth factor (IGF)-1 signaling (IIS) is an important pathway that controls larval diapause and adult lifespan. The IIS pathway is modulated by many insulin-like peptides (ILPs) through the DAF-2 receptor, the sole insulin/IGF-1 receptor-like protein in C. elegans. We previously identified the ILP, INS-18, and predicted its tertiary structure to be similar to the crystal structures of human insulin and IGF-1. In this study, the physiological function of INS-18 was first examined by gene disruption and overexpression, and we identified INS-18 as a DAF-2 antagonist required for larval diapause and longevity...
July 6, 2012: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/22511947/a-directed-rnai-screen-based-on-larval-growth-arrest-reveals-new-modifiers-of-c-elegans-insulin-signaling
#15
Ola Billing, Balasubramanian Natarajan, Ateequrrahman Mohammed, Peter Naredi, Gautam Kao
Genes regulating Caenorhabditis elegans insulin/IGF signaling (IIS) have largely been identified on the basis of their involvement in dauer development or longevity. A third IIS phenotype is the first larval stage (L1) diapause, which is also influenced by asna-1, a regulator of DAF-28/insulin secretion. We reasoned that new regulators of IIS strength might be identified in screens based on the L1 diapause and the asna-1 phenotype. Eighty- six genes were selected for analysis by virtue of their predicted interaction with ASNA-1 and screened for asna-1-like larval arrest...
2012: PloS One
https://www.readbyqxmd.com/read/21933341/pkc-1-regulates-daf-2-insulin-igf-signalling-dependent-control-of-dauer-formation-in-caenorhabditis-elegans
#16
José M Monje, Ana M Brokate-Llanos, Mercedes M Pérez-Jiménez, Manuel A Fidalgo, Manuel J Muñoz
In Caenorhabditis elegans, the insulin/IGF pathway participates in the decision to initiate dauer development. Dauer is a diapause stage that is triggered by environmental stresses, such as a lack of nutrients. Insulin/IGF receptor mutants arrest constitutively in dauer, an effect that can be suppressed by mutations in other elements of the insulin/IGF pathway or by a reduction in the activity of the nuclear hormone receptor daf-12. We have isolated a pkc-1 mutant that acts as a novel suppressor of the dauer phenotypes caused by insulin/IGF receptor mutations...
December 2011: Aging Cell
https://www.readbyqxmd.com/read/21533078/pdp-1-links-the-tgf-%C3%AE-and-iis-pathways-to-regulate-longevity-development-and-metabolism
#17
Sri Devi Narasimhan, Kelvin Yen, Ankita Bansal, Eun-Soo Kwon, Srivatsan Padmanabhan, Heidi A Tissenbaum
The insulin/IGF-1 signaling (IIS) pathway is a conserved regulator of longevity, development, and metabolism. In Caenorhabditis elegans IIS involves activation of DAF-2 (insulin/IGF-1 receptor tyrosine kinase), AGE-1 (PI 3-kinase), and additional downstream serine/threonine kinases that ultimately phosphorylate and negatively regulate the single FOXO transcription factor homolog DAF-16. Phosphatases help to maintain cellular signaling homeostasis by counterbalancing kinase activity. However, few phosphatases have been identified that negatively regulate the IIS pathway...
April 2011: PLoS Genetics
https://www.readbyqxmd.com/read/20944013/insulin-insulin-like-growth-factor-signaling-controls-non-dauer-developmental-speed-in-the-nematode-caenorhabditis-elegans
#18
Anne-Françoise Ruaud, Iskra Katic, Jean-Louis Bessereau
Identified as a major pathway controlling entry in the facultative dauer diapause stage, the DAF-2/Insulin receptor (InsR) signaling acts in multiple developmental and physiological regulation events in Caenorhabditis elegans. Here we identified a role of the insulin-like pathway in controlling developmental speed during the C. elegans second larval stage. This role relies on the canonical DAF-16/FOXO-dependent branch of the insulin-like signaling and is largely independent of dauer formation. Our studies provide further evidence for broad conservation of insulin/insulin-like growth factor (IGF) functions in developmental speed control...
January 2011: Genetics
https://www.readbyqxmd.com/read/20613724/a-new-daf-16-isoform-regulates-longevity
#19
Eun-Soo Kwon, Sri Devi Narasimhan, Kelvin Yen, Heidi A Tissenbaum
The insulin/IGF-1 signalling (IIS) pathway has diverse roles from metabolism to longevity. In Caenorhabditis elegans, the single forkhead box O (FOXO) homologue, DAF-16, functions as the major target of the IIS pathway. One of two isoforms, DAF-16a, is known to regulate longevity, stress response and dauer diapause. However, it remains unclear how DAF-16 achieves its specificity in regulating these various biological processes. Here we identify a new isoform, DAF-16d/f, as an important isoform regulating longevity...
July 22, 2010: Nature
https://www.readbyqxmd.com/read/19901535/inaktivation-of-insulin-igf-1-signaling-by-dephosphorylation
#20
Sri Devi Narasimhan, Arnab Mukhopadhyay, Heidi A Tissenbaum
Signal transduction pathways are tightly regulated by phosphorylation-dephosphorylation cycles and yet the mammalian genome contains far more genes that encode for protein kinases than protein phosphatases. Therefore, to target specific substrates, many phosphatases associate with distinct regulatory subunits and thereby modulate multiple cellular processes. One such example is the C. elegans PP2A regulatory subunit PPTR-1 that negatively regulates the insulin/insulin-like growth factor signaling pathway to modulate longevity, dauer diapause, fat metabolism and stress resistance...
December 2009: Cell Cycle
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