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https://www.readbyqxmd.com/read/29329263/effect-of-radiological-countermeasures-on-subjective-well-being-and-radiation-anxiety-after-the-2011-disaster-the-fukushima-health-management-survey
#1
Michio Murakami, Yoshitake Takebayashi, Yoshihito Takeda, Akiko Sato, Yasumasa Igarashi, Kazumi Sano, Tetsuo Yasutaka, Wataru Naito, Sumire Hirota, Aya Goto, Tetsuya Ohira, Seiji Yasumura, Koichi Tanigawa
After the Fukushima Daiichi Nuclear Power Station accident in 2011, concerns about radiation exposure and decline in subjective well-being have been reported. To tackle these problems, various countermeasures in relation to radiation have been implemented. In this study, we comprehensively evaluated the effects of radiological countermeasures on subjective well-being (e.g., satisfaction with life (SWL) and emotional well-being) and radiation anxiety, through a questionnaire survey targeting Fukushima residents (N = 1023)...
January 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29309266/radiation-induced-long-noncoding-rnas-in-a-mouse-model-after-whole-body-irradiation
#2
Molykutty J Aryankalayil, Sunita Chopra, Joel Levin, Iris Eke, Adeola Makinde, Shaoli Das, Uma Shankavaram, Claire Vanpouille-Box, Sandra Demaria, C Norman Coleman
Long noncoding RNAs (lncRNAs) are emerging as key molecules in regulating many biological processes and have been implicated in development and disease pathogenesis. Biomarkers of cancer and normal tissue response to treatment are of great interest in precision medicine, as well as in public health and medical management, such as for assessment of radiation injury after an accidental or intentional exposure. Circulating and functional RNAs, including microRNAs (miRNAs) and lncRNAs, in whole blood and other body fluids are potential valuable candidates as biomarkers...
January 8, 2018: Radiation Research
https://www.readbyqxmd.com/read/29283379/a-metabolomic-and-lipidomic-serum-signature-from-nonhuman-primates-administered-with-a-promising-radiation-countermeasure-gamma-tocotrienol
#3
Amrita K Cheema, Khyati Y Mehta, Oluseyi O Fatanmi, Stephen Y Wise, Charles P Hinzman, Josh Wolff, Vijay K Singh
The development of radiation countermeasures for acute radiation syndrome (ARS) has been underway for the past six decades, leading to the identification of multiple classes of radiation countermeasures. However, to date, only two growth factors (Neupogen and Neulasta) have been approved by the United States Food and Drug Administration (US FDA) for the mitigation of hematopoietic acute radiation syndrome (H-ARS). No radioprotector for ARS has been approved by the FDA yet. Gamma-tocotrienol (GT3) has been demonstrated to have radioprotective efficacy in murine as well as nonhuman primate (NHP) models...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29251020/podophyllotoxin-and-rutin-in-combination-prevents-oxidative-stress-mediated-cell-death-and-advances-revival-of-mice-gastrointestine-following-lethal-radiation-injury
#4
Ajaswrata Dutta, Manju Lata Gupta, Savita Verma
Intestinal injury is inevitable during exposure to high radiation doses and is a common side effect observed during abdominal/pelvic radiotherapy. Yet no radiation countermeasures are available for gastrointestine (GI) injury management. The aim of this study is to determine the effects of podophyllotoxin and rutin in combination (G-003M) on ionizing radiation induced GI injury. We prophylactically administered G-003M to C57BL/6J mice exposed to 9-Gy total body radiation (TBI) and assessed for morphological changes, loss in absorption, fluid retention, biochemical alterations, immunohistochemical analysis to study cPARP, caspase-3, PCNA expression and TUNEL staining...
December 17, 2017: Free Radical Research
https://www.readbyqxmd.com/read/29235452/comparison-of-external-doses-between-radio-contaminated-areas-and-areas-with-high-natural-terrestrial-background-using-the-individual-dosimeter-d-shuttle-75-months-after-the-fukushima-daiichi-nuclear-power-plant-accident
#5
Masaharu Tsubokura, Shuhei Nomura, Izumi Yoshida, Toyoaki Sawano, Makoto Miyazaki, Satoru Tomita, Tomoyoshi Oikawa, Masami Watanabe
After the Fukushima Daiichi nuclear power plant accident, the air dose gradually decreases every year due to the physical decay of radioactive materials and environmental changes as well as countermeasures. However, there is little information on personal behavioral patterns and individual dose from external exposure among the inhabitants around the nuclear power plant. To evaluate the dose from external exposure in Minamisoma city and compare the differences with outside of Fukushima, we started the external dose assessment project in cooperation with city officials in Minamisoma as well as other three cities in Japan, where the natural terrestrial background radiation level is relatively high...
December 13, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29230065/the-toll-like-receptor-2-6-agonist-fsl-1-lipopeptide-therapeutically-mitigates-acute-radiation-syndrome
#6
Cathryn J Kurkjian, Hao Guo, Nathan D Montgomery, Ning Cheng, Hong Yuan, Joseph R Merrill, Gregory D Sempowski, W June Brickey, Jenny P-Y Ting
Risks of radiation exposure from nuclear incidents and cancer radiotherapy are undeniable realities. These dangers urgently compel the development of agents for ameliorating radiation-induced injuries. Biologic pathways mediated by myeloid differentiation primary response gene 88 (MyD88), the common adaptor for toll-like receptor (TLR) and Interleukin-1 receptor signaling, are critical for radioprotection. Treating with agonists prior to radiation enhances survival by activating TLR signaling, whereas radiomitigating TLR-activating therapeutics given after exposure are less defined...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29206597/quantitative-proteomic-analysis-of-the-hippocampus-of-rats-with-gcr-induced-spatial-memory-impairment
#7
Sucharita M Dutta, Melissa M Hadley, Scott Peterman, Jessica S Jewell, Vania D Duncan, Richard A Britten
NASA is planning future missions to Mars, which will result in astronauts being exposed to ∼13 cGy/year of galactic cosmic radiation (GCR). Previous ground-based experiments have demonstrated that low (15 cGy) doses of 1 GeV/n 56Fe ions impair hippocampus-dependent spatial memory in rats. However, some irradiated rats maintain a spatial memory performance comparable to that seen in the sham-irradiated rats, suggesting that some of these animals are able to ameliorate the deleterious effects of the GCR, while others are not...
December 5, 2017: Radiation Research
https://www.readbyqxmd.com/read/29198313/modifiers-of-radiation-effects-in-the-eye
#8
REVIEW
Norman J Kleiman, Fiona A Stewart, Eric J Hall
World events, including the threat of radiological terrorism and the fear of nuclear accidents, have highlighted an urgent need to develop medical countermeasures to prevent or reduce radiation injury. Similarly, plans for manned spaceflight to a near-Earth asteroid or journey to Mars raise serious concerns about long-term effects of space radiation on human health and the availability of suitable therapeutic interventions. At the same time, the need to protect normal tissue from the deleterious effects of radiotherapy has driven considerable research into the design of effective radioprotectors...
November 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29193982/biodosimetry-a-future-tool-for-medical-management-of-radiological-emergencies
#9
Mary T Sproull, Kevin A Camphausen, Gregory D Koblentz
With the threat of future radiological or nuclear events, there is a need to model and develop new medical countermeasures for managing large-scale population exposures to radiation. The field of radiation biodosimetry has advanced far beyond its original objectives to identify new methodologies to quantitate unknown levels of radiation exposure that may be applied in a mass screening setting. New research in the areas of genomics, proteomics, metabolomics, transcriptomics, and electron paramagnetic resonance (EPR) applications have identified novel biological indicators of radiation injury from a diverse array of biological sample materials, and studies continue to develop more advanced models of radiation exposure and injury...
December 1, 2017: Health Security
https://www.readbyqxmd.com/read/29180765/the-inhibitory-effect-of-minocycline-on-radiation-induced-neuronal-apoptosis-via-ampk%C3%AE-1-signaling-mediated-autophagy
#10
Liyuan Zhang, Ping Huang, Hui Chen, Wen Tan, Jiawei Lu, Wei Liu, Jingdong Wang, Shuyu Zhang, Wei Zhu, Jianping Cao, Ye Tian, Hongying Yang
Due to an increasing concern about radiation-induced cognitive deficits for brain tumor patients receiving radiation therapy, developing and evaluating countermeasures has become inevitable. Our previous study has found that minocycline, a clinical available antibiotics that can easily cross the blood brain barrier, mitigates radiation-induced long-term memory loss in rats, accompanied by decreased hippocampal neuron apoptosis. Thus, in the present study, we report an unknown mechanism underlying the neuroprotective effect of minocycline...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29163150/targeting-dna-repair-through-podophyllotoxin-and-rutin-formulation-in-hematopoietic-radioprotection-an-in-silico-in-vitro-and-in-vivo-study
#11
M H Yashavarddhan, Sandeep K Shukla, Pankaj Chaudhary, Nitya N Srivastava, Jayadev Joshi, Mrutyunjay Suar, Manju L Gupta
Drug discovery field has tremendously progressed during last few decades, however, an effective radiation countermeasure agent for the safe administration to the victims of radiation exposure is still unavailable. This multi-model study is aimed at elucidating the mechanistic aspects of a novel podophyllotoxin and rutin combination (henceforth referred as G-003M) in the hematopoietic radioprotection and its involvement in the DNA damage and repair signaling pathways. Using in silico study, we identified the binding sites and structural components of G-003M and validated in vitro...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29141658/thioredoxin-mitigates-radiation-induced-hematopoietic-stem-cell-injury-in-mice
#12
Pasupathi Sundaramoorthy, Qinhong Wang, Zhihong Zheng, Yiqun Jiao, Benny J Chen, Phuong L Doan, Nelson J Chao, Yubin Kang
BACKGROUND: Radiation exposure poses a significant threat to public health. Hematopoietic injury is one of the major manifestations of acute radiation sickness. Protection and/or mitigation of hematopoietic stem cells (HSCs) from radiation injury is an important goal in the development of medical countermeasure agents (MCM). We recently identified thioredoxin (TXN) as a novel molecule that has marked protective and proliferative effects on HSCs. In the current study, we investigated the effectiveness of TXN in rescuing mice from a lethal dose of total body radiation (TBI) and in enhancing hematopoietic reconstitution following a lethal dose of irradiation...
November 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29135537/status-and-perception-of-risk-management-in-radiation-therapy-survey-among-korean-medical-physicists
#13
Sohyun Ahn, Dong Oh Shin, Sang Hyoun Choi, Jihye Koo, Soon Sung Lee, Dong-Wook Park, Yoon-Jin Oh, Sohyun Park, Dong Wook Kim
This study was conducted as part of an endeavor to improve the risk management system of radiation therapy departments in the Republic of Korea. An online survey on the status and perception of Korea's medical physicists on risk management in radiation therapy was carried out. A total of 40 domestic radiation oncology departments participated. This survey is divided into three categories: (1) work environment; (2) risk management status; and (3) opinions on how to improve risk management. Based on the results of the survey, the conclusions that can be derived are (1) the majority of respondents have a high interest in the risk management of radiation therapy; (2) the lack of staffing is one cause of risk management difficulties; (3) a risk-related terminology and classification system at the national or professional association level are required; (4) each hospital should create a voluntary reporting system for the handling of incidents; (5) medical physicists should establish incident reporting, analysis and countermeasures; and (6) government should develop education and training programs...
November 10, 2017: Health Physics
https://www.readbyqxmd.com/read/29053152/heart-in-space-effect-of-the-extraterrestrial-environment-on-the-cardiovascular-system
#14
REVIEW
Richard L Hughson, Alexander Helm, Marco Durante
National space agencies and private corporations aim at an extended presence of humans in space in the medium to long term. Together with currently suboptimal technology, microgravity and cosmic rays raise health concerns about deep-space exploration missions. Both of these physical factors affect the cardiovascular system, whose gravity-dependence is pronounced. Heart and vascular function are, therefore, susceptible to substantial changes in weightlessness. The altered cardiovascular function in space causes physiological problems in the postflight period...
October 20, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29035153/acute-and-chronic-kidney-injury-in-a-non-human-primate-model-of-partial-body-irradiation-with-bone-marrow-sparing
#15
Eric P Cohen, Kim G Hankey, Alexander W Bennett, Ann M Farese, George A Parker, Thomas J MacVittie
The development of medical countermeasures against acute and delayed multi-organ injury requires animal models predictive of the human response to radiation and its treatment. Late chronic injury is a well-known feature of radiation nephropathy, but acute kidney injury has not been reported in an appropriate animal model. We have established a single-fraction partial-body irradiation model with minimal marrow sparing in non-human primates. Subject-based medical management was used including parenteral fluids according to prospective morbidity criteria...
October 16, 2017: Radiation Research
https://www.readbyqxmd.com/read/29023398/the-impact-of-oxidative-stress-on-the-bone-system-in-response-to-the-space-special-environment
#16
REVIEW
Ye Tian, Xiaoli Ma, Chaofei Yang, Peihong Su, Chong Yin, Ai-Rong Qian
The space special environment mainly includes microgravity, radiation, vacuum and extreme temperature, which seriously threatens an astronaut's health. Bone loss is one of the most significant alterations in mammalians after long-duration habitation in space. In this review, we summarize the crucial roles of major factors-namely radiation and microgravity-in space in oxidative stress generation in living organisms, and the inhibitory effect of oxidative stress on bone formation. We discussed the possible mechanisms of oxidative stress-induced skeletal involution, and listed some countermeasures that have therapeutic potentials for bone loss via oxidative stress antagonism...
October 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28963717/bio-300-a-nanosuspension-of-genistein-mitigates-pneumonitis-fibrosis-following-high-dose-radiation-exposure-in-the-c57l-j-murine-model
#17
Isabel L Jackson, Andrew Zodda, Ganga Gurung, Radmila Pavlovic, Michael D Kaytor, Michael A Kuskowski, Zeljko Vujaskovic
BACKGROUND AND PURPOSE: BIO 300 nanosuspension (Humanetics Corporation) is being developed as a medical countermeasure (MCM) for the mitigation of the delayed effects of acute radiation exposure, specifically pneumonitis and fibrosis of the lung. The objective of this study was to determine the best dose and treatment duration of BIO 300 to mitigate lung injury and improve the likelihood for survival in C57L/J mice exposed to whole thorax lung irradiation (WTLI). EXPERIMENTAL APPROACH: Age- and sex-matched C57L/J mice received a single dose of 11...
September 30, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28957385/additional-risk-of-diabetes-exceeds-the-increased-risk-of-cancer-caused-by-radiation-exposure-after-the-fukushima-disaster
#18
Michio Murakami, Masaharu Tsubokura, Kyoko Ono, Shuhei Nomura, Tomoyoshi Oikawa
The 2011 Fukushima disaster led to increases in multiple risks (e.g., lifestyle diseases and radiation exposure) and fear among the public. Here, we assessed the additional risks of cancer caused by radiation and diabetes related to the disaster and the cost-effectiveness of countermeasures against these conditions. Our study included residents of the cities of Minamisoma and Soma (10-40 km and 35-50 km north of the Fukushima Daiichi (N° 1) Nuclear Power Station, respectively). We used the loss of life expectancy (LLE) as an indicator to compare risks between radiation exposure and diabetes...
2017: PloS One
https://www.readbyqxmd.com/read/28877030/radiation-mitigating-properties-of-intranasally-administered-kl4-surfactant-in-a-murine-model-of-radiation-induced-lung-damage
#19
Melpo Christofidou-Solomidou, Ralph A Pietrofesa, Evguenia Arguiri, Constantinos Koumenis, Robert Segal
The threat of exposure to ionizing radiation from a nuclear reactor accident or deliberate terrorist actions is a significant public health concern. The lung is particularly susceptible to radiation-induced injury from external sources or inhalation of radioactive particles from radioactive fallout. Radiation-induced lung disease can manifest with an acute radiation pneumonitis and/or delayed effects leading to pulmonary fibrosis. As prior warning of radiation exposure is unlikely, medical countermeasures (MCMs) to mitigate radiation-induced lung disease that can be given in mass-casualty situations many hours or days postirradiation are needed to prevent both early and late lung damage...
November 2017: Radiation Research
https://www.readbyqxmd.com/read/28871103/lipidomic-dysregulation-within-the-lung-parenchyma-following-whole-thorax-lung-irradiation-markers-of-injury-inflammation-and-fibrosis-detected-by-maldi-msi
#20
Claire L Carter, Jace W Jones, Ann M Farese, Thomas J MacVittie, Maureen A Kane
Radiation-induced lung injury (RILI) is a delayed effect of acute radiation exposure that can limit curative cancer treatment therapies and cause lethality following high-dose whole-thorax lung irradiation (WTLI). To date, the exact mechanisms of injury development following insult remain ill-defined and there are no FDA approved pharmaceutical agents or medical countermeasures. Traditionally, RILI development is considered as three phases, the clinically latent period, the intermediate acute pneumonitis phase and the later fibrotic stage...
September 4, 2017: Scientific Reports
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