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https://www.readbyqxmd.com/read/28097629/radiomitigation-and-tissue-repair-activity-of-systemically-administered-therapeutic-peptide-tp508-is-enhanced-by-pegylation
#1
Scott D McVicar, Kempaiah Rayavara, Darrell H Carney
TP508 is a synthetically derived tissue repair peptide that has previously demonstrated safety and potential efficacy in phase I/II clinical trials for the treatment of diabetic foot ulcers. Recent studies show that a single injection of TP508 administered 24 h after irradiation significantly increases survival and delays mortality in murine models of acute radiation mortality. Thus, TP508 is being developed as a potential nuclear countermeasure. Because of the short plasma half-life of TP508, we hypothesize that increasing the peptide bioavailability would increase TP508 efficacy or reduce the dosage required for therapeutic effects...
January 17, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28068518/impact-of-space-environment-on-stability-of-medicines-challenges-and-prospects
#2
REVIEW
Priti Mehta, Dhara Bhayani
To upkeep health of astronauts in a unique, isolated, and extreme environment of space is the primary goal for a successful space mission, hence, safe and efficacious medications are essential for the wellness of astronauts. Space medication has been challenged with problems related to efficacy. Along with altered physiology, one of the possible reasons could be instability of space medications in the presence of harsh spaceflight environmental conditions. Altered physical and chemical stability can result in reduced potency which can result in reduced efficacy...
January 3, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28048634/tu-h-brb-01-physics-and-dosimetry-for-radiation-countermeasure-research
#3
J Bourland
: The US government has substantial research and development activities underway for medical countermeasures that will insure the long-term safety and survival of the country's population after unfortunate large-scale biological, chemical and radiological and nuclear events. Preparedness includes research and development of medical countermeasures to address radiation-induced cutaneous and internal injury from radiation and nuclear events as well as for minimizing radiation risks incurred during and after travel in space...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048539/tu-h-brb-04-radiation-countermeasures-and-the-nci-radiation-research-program
#4
P Prasanna
: The US government has substantial research and development activities underway for medical countermeasures that will insure the long-term safety and survival of the country's population after unfortunate large-scale biological, chemical and radiological and nuclear events. Preparedness includes research and development of medical countermeasures to address radiation-induced cutaneous and internal injury from radiation and nuclear events as well as for minimizing radiation risks incurred during and after travel in space...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047970/tu-h-brb-02-the-niaid-radiation-nuclear-medical-countermeasures-program
#5
L Taliaferro
: The US government has substantial research and development activities underway for medical countermeasures that will insure the long-term safety and survival of the country's population after unfortunate large-scale biological, chemical and radiological and nuclear events. Preparedness includes research and development of medical countermeasures to address radiation-induced cutaneous and internal injury from radiation and nuclear events as well as for minimizing radiation risks incurred during and after travel in space...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047879/tu-h-brb-05-radiation-countermeasures-and-the-nasa-space-radiation-program
#6
J Huff
: The US government has substantial research and development activities underway for medical countermeasures that will insure the long-term safety and survival of the country's population after unfortunate large-scale biological, chemical and radiological and nuclear events. Preparedness includes research and development of medical countermeasures to address radiation-induced cutaneous and internal injury from radiation and nuclear events as well as for minimizing radiation risks incurred during and after travel in space...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046580/tu-h-brb-00-radiation-countermeasures-research-and-development
#7
J Daniel
: The US government has substantial research and development activities underway for medical countermeasures that will insure the long-term safety and survival of the country's population after unfortunate large-scale biological, chemical and radiological and nuclear events. Preparedness includes research and development of medical countermeasures to address radiation-induced cutaneous and internal injury from radiation and nuclear events as well as for minimizing radiation risks incurred during and after travel in space...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046476/tu-h-brb-03-the-barda-chemical-radiological-nuclear-countermeasures-effort
#8
T Hu
: The US government has substantial research and development activities underway for medical countermeasures that will insure the long-term safety and survival of the country's population after unfortunate large-scale biological, chemical and radiological and nuclear events. Preparedness includes research and development of medical countermeasures to address radiation-induced cutaneous and internal injury from radiation and nuclear events as well as for minimizing radiation risks incurred during and after travel in space...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27910404/using-a-priori-knowledge-for-developing-bolometric-tomography-in-toroidal-devices
#9
Ryuichi Sano, Byron J Peterson, Kiyofumi Mukai, Masaru Teranishi, Naofumi Iwama, Masahiro Kobayashi
In tomographic imaging of magnetically confined toroidal plasmas, a countermeasure against missing observation has been studied in terms of the adoption of prior information based on modelled plasma profiles. The Tikhonov regularization for image reconstruction is extended by the use of the Euclidean distance. A procedure of model fitting is designed in order to adaptively generate the reference image. The new method is tested on a typical example of ill-conditioned tomography, that is, the three-dimensional imaging-bolometer tomography in the large helical device...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909158/off-site-emergency-planning-at-uk-nuclear-licensed-sites
#10
Paul Leonard, Gareth Thomas
Nuclear emergency planning arrangements in the UK are continually kept under review. This work proposes to outline how experience from nuclear exercises and undertaking emergency response duties can be based on radiological knowledge of specific sites and utilised in the future. In 2014, the UK regulator, the Office for Nuclear Regulation (ONR) revised their principles for the determination of off-site emergency planning areas around nuclear sites where predetermined countermeasures and other protection measures are applied to protect those people who may be affected by a radiation emergency...
December 1, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27897218/radiation-induced-magnetization-reversal-causing-a-large-flux-loss-in-undulator-permanent-magnets
#11
Teruhiko Bizen, Ryota Kinjo, Teruaki Hasegawa, Akihiro Kagamihata, Yuichiro Kida, Takamitsu Seike, Takahiro Watanabe, Toru Hara, Toshiro Itoga, Yoshihiro Asano, Takashi Tanaka
We report an unexpectedly large flux loss observed in permanent magnets in one of the undulators operated in SACLA, the x-ray free electron laser facility in Japan. Characterizations of individual magnets extracted from the relevant undulator have revealed that the flux loss was caused by a homogeneous magnetization reversal extending over a wide area, but not by demagnetization of individual magnets damaged by radiation. We show that the estimated flux-loss rate is much higher than what is reported in previous papers, and its distribution is much more localized to the upstream side...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27888688/an-oral-hemokine-tm-%C3%AE-methylhydrocinnamate-enhances-myeloid-and-neutrophil-recovery-following-irradiation-in-vivo
#12
Douglas V Faller, Serguei A Castaneda, Daohong Zhou, Merriline Vedamony, Peter E Newburger, Gary L White, Stanley Kosanke, P Artur Plett, Christie M Orschell, Michael S Boosalis, Susan P Perrine
An oral therapeutic which reduces duration of cytopenias and is active following accidental radiation exposures is an unmet need in radiation countermeasures. Alpha methylhydrocinnamate (ST7) prolongs STAT-5 phosphorylation, reduces growth-factor dependency of multi-lineage cell lines, and stimulates erythropoiesis. Here, ST7 and its isomers were studied for their effects on myeloid progenitors and hematopoietic stem cells (HSCs) following radiation, in nonhuman primates, and murine irradiation models. Addition of ST7 or ST7-S increased CFU-GM production by 1...
October 31, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27881872/in-vitro-and-in-vivo-assessment-of-direct-effects-of-simulated-solar-and-galactic-cosmic-radiation-on-human-hematopoietic-stem-progenitor-cells
#13
C Rodman, G Almeida-Porada, S K George, J Moon, S Soker, T Pardee, M Beaty, P Guida, S P Sajuthi, C D Langefeld, S J Walker, P F Wilson, C D Porada
Future deep space missions to Mars and near-Earth asteroids will expose astronauts to chronic solar energetic particles (SEP) and galactic cosmic ray (GCR) radiation, and likely one or more solar particle events (SPEs). Given the inherent radiosensitivity of hematopoietic cells and short latency period of leukemias, space radiation-induced hematopoietic damage poses a particular threat to astronauts on extended missions. We show that exposing human hematopoietic stem/progenitor cells (HSC) to extended mission-relevant doses of accelerated high-energy protons and iron ions leads to the following: (1) introduces mutations that are frequently located within genes involved in hematopoiesis and are distinct from those induced by γ-radiation; (2) markedly reduces in vitro colony formation; (3) markedly alters engraftment and lineage commitment in vivo; and (4) leads to the development, in vivo, of what appears to be T-ALL...
December 9, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27849061/mitigation-of-radiation-induced-hematopoietic-injury-by-the-polyphenolic-acetate-7-8-diacetoxy-4-methylthiocoumarin-in-mice
#14
Kavya Venkateswaran, Anju Shrivastava, Paban K Agrawala, Ashok Prasad, Namita Kalra, Parvat R Pandey, Kailash Manda, Hanumantharao G Raj, Virinder S Parmar, Bilikere S Dwarakanath
Protection of the hematopoietic system from radiation damage, and/or mitigation of hematopoietic injury are the two major strategies for developing medical countermeasure agents (MCM) to combat radiation-induced lethality. In the present study, we investigated the potential of 7, 8-diacetoxy-4-methylthiocoumarin (DAMTC) to ameliorate radiation-induced hematopoietic damage and the associated mortality following total body irradiation (TBI) in C57BL/6 mice. Administration of DAMTC 24 hours post TBI alleviated TBI-induced myelo-suppression and pancytopenia, by augmenting lymphocytes and WBCs in the peripheral blood of mice, while bone marrow (BM) cellularity was restored through enhanced proliferation of the stem cells...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27832656/perifocal-inflammatory-reaction-with-volume-fluctuation-caused-by-diagnostic-radiation-induced-regression-in-germinoma-makes-histological-diagnosis-difficult-despite-its-disappearance-following-treatment-a-significant-pitfall-and-countermeasures-to-it
#15
Yuichiro Yoneoka, Junichi Yoshimura, Masayasu Okada, Yukihiko Fujii
We present a pediatric case of neurohypophyseal germinoma with a perifocal inflammatory reaction (PIR) with volume fluctuation caused by diagnostic radiation-induced regression (DRIR). On-target biopsy failed to confirm the histology because PIR hardly contained any germinoma cells. DRIR-related fluctuation of the tumor volume disguised germinoma as inflammation. We analyzed the cerebrospinal fluid (CSF) and detected a high level of placental alkaline phosphatase (PLAP), which demonstrated the neurohypophyseal lesion to be germinoma and brought the patient from successful radiochemotherapy up to complete remission...
November 11, 2016: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27817217/spaceflight-induced-changes-in-the-human-proteome
#16
Alexey S Kononikhin, Natalia L Starodubtseva, Lyudmila Kh Pastushkova, Daria N Kashirina, Kristina Yu Fedorchenko, Alexander G Brhozovsky, Igor A Popov, Irina M Larina, Evgeny N Nikolaev
Spaceflight is one of the most extreme conditions encountered by humans: Individuals are exposed to radiation, microgravity, hypodynamia, and will experience isolation. A better understanding of the molecular processes induced by these factors may allow us to develop personalized countermeasures to minimize risks to astronauts. Areas covered: This review is a summary of literature searches from PubMed, NASA, Roskosmos and the authors' research experiences and opinions. The review covers the available proteomic data on the effects of spaceflight factors on the human body, including both real space missions and ground-based model experiments...
January 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27806643/manganese-superoxide-dismutase-gene-modified-mesenchymal-stem-cells-attenuates-acute-radiation-induced-lung-injury
#17
HaiXu Chen, Hang Xiang, BenYan Wu, XiaoMei Zhang, Ming Li, Juan Liu, Jun Li, ZhaoQi Ren, Bin Du, KunLun He, Qiang Zeng, Chao Yang
Radiation-induced lung injury (RILI) is a major clinical complication for radiotherapy in thoracic tumors. An immediate effect of lung irradiation is the generation of reactive oxygen (ROS) that can produce oxidative damage to DNA, lipids, and proteins resulting in lung cell injury or death. Currently, the medical management of RILI remains supportive. Therefore, there is an urgent need for the development of countermeasures. The present study was aimed to evaluate the protective effect of manganese superoxide dismutase (MnSOD) gene modified mesenchymal stem cells (MSCs) to facilitate the improved recovery of RILI...
November 2, 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27758131/assessment-of-nutritional-status-of-iodine-through-urinary-iodine-screening-among-local-children-and-adolescents-after-the-fukushima-daiichi-nuclear-power-plant-accident
#18
Masaharu Tsubokura, Shuhei Nomura, Hajime Watanobe, Yoshitaka Nishikawa, Chiaki Suzuki, Sae Ochi, Claire Leppold, Hirokatsu Kinoshita, Shigeaki Kato, Yasutoshi Saito
BACKGROUND: Iodine deficiency is an important modifier of the risk of thyroid cancer following irradiation. However, little information is available on the prevalence of iodine deficiency in Fukushima and its surroundings after the Fukushima Daiichi nuclear power plant accident that occurred in March 2011. METHODS: In order to assess urinary iodine concentrations (UIC) and the prevalence of iodine deficiency and to elucidate any associations between demographic characteristics and UIC levels among children and adolescents aged ≤18 years at the time of the accident in Fukushima Prefecture and its surroundings, the data on voluntary UIC testing conducted by Hirata Central Hospital, Fukushima, were evaluated...
December 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27740889/long-term-cognitive-functioning-in-single-dose-total-body-gamma-irradiated-rhesus-monkeys-macaca-mulatta
#19
David B Hanbury, Ann M Peiffer, Greg Dugan, Rachel N Andrews, J Mark Cline
In this study, the effects of a potentially lethal radiation exposure on the brain for long-term cognitive sequelae were investigated using Rhesus macaques ( Macaca mulatta ) adopted from other facilities after analysis of acute radiation response via the Centers for Medical Countermeasures against Radiation (CMCR) network. Fifty-nine animals were given the opportunity to participate in cognitive cage-side testing. The animals that received single-dose gamma irradiation were significantly less likely to engage in cognitive testing than the controls, suggesting that irradiated animals may have differences in cognitive ability...
November 2016: Radiation Research
https://www.readbyqxmd.com/read/27710702/state-of-the-art-advances-in-radiation-biodosimetry-for-mass-casualty-events-involving-radiation-exposure
#20
Mary Sproull, Kevin Camphausen
With the possibility of large-scale terrorist attacks around the world, the need for modeling and development of new medical countermeasures for potential future chemical, biological, radiological and nuclear (CBRN) has been well established. Project Bioshield, initiated in 2004, provided a framework to develop and expedite research in the field of CBRN exposures. To respond to large-scale population exposures from a nuclear event or radiation dispersal device (RDD), new methods for determining received dose using biological modeling became necessary...
November 2016: Radiation Research
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