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https://www.readbyqxmd.com/read/28270486/polypoidal-choroidal-vasculopathy-a-common-type-of-neovascular-age-related-macular-degeneration-in-caucasians
#1
Sohraab Yadav, David G Parry, Nick A V Beare, Ian A Pearce
AIMS: To describe the prevalence of polypoidal choroidal vasculopathy (PCV) in a Caucasian population with neovascular age-related macular degeneration (NAMD). METHODS: All patients referred to a city AMD service over a 2-year period underwent imaging including Indocyanine Green Angiography at baseline. A panel of experts confirmed the patients with NAMD and diagnosed the lesion type including PCV. The proportion of Caucasian patients with PCV was identified. Two authors independently reviewed clinical imaging and recorded data of patients with PCV on lesion characteristics...
March 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28266609/incidence-and-risk-factors-of-retreatment-after-three-monthly-aflibercept-therapy-for-exudative-age-related-macular-degeneration
#2
Wataru Kikushima, Yoichi Sakurada, Seigo Yoneyama, Atsushi Sugiyama, Naohiko Tanabe, Atsuki Kume, Fumihiko Mabuchi, Hiroyuki Iijima
Though anti-vascular endothelial growth factor therapy has become the standard treatment for exudative age-related macular degeneration (AMD), retreatment after the initial loading injection is inevitable in most eyes with residual or recurrent exudative changes. In the present study, we studied 140 treatment naïve eyes with typical neovascular AMD (n = 71) or polypoidal choroidal vasculopathy (PCV) (n = 69) and investigated the incidence and risk factors of retreatment after 3-monthly intravitreal aflibercept injection for exudative AMD during the 12-month period...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28251353/prevalence-and-characteristics-of-pseudodrusen-subtypes-in-advanced-age-related-macular-degeneration
#3
Taiyo Shijo, Yoichi Sakurada, Seigo Yoneyama, Atsushi Sugiyama, Wataru Kikushima, Naohiko Tanabe, Hiroyuki Iijima
PURPOSE: The purpose of our study was to investigate the clinical and genetic characteristics of pseudodrusen subtypes and their incidence in advanced age-related macular degeneration (AMD). METHODS: We studied 84 eyes from 84 patients with pseudodrusen associated with advanced AMD, including typical AMD, polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP), and geographic atrophy (GA). Multiple imaging modalities, including color fundus photography, spectral-domain optical coherence tomography (SD-OCT), near-infrared reflectance, and fundus autofluorescence, were employed to diagnose pseudodrusen and its subtypes...
March 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28196060/angiographic-subtypes-of-polypoidal-choroidal-vasculopathy-in-taiwan-a-prospective-multicenter-study
#4
Ling Yeung, Chien-Neng Kuo, An-Ning Chao, Kuan-Jen Chen, Wei-Chi Wu, Chien-Hsiung Lai, Nan-Kai Wang, Yih-Shiou Hwang, Ching-Lung Chen, Chi-Chun Lai
PURPOSE: To determine the incidence and clinical characteristics of angiographic subtypes of polypoidal choroidal vasculopathy (PCV). METHODS: It is a prospective, multicenter, cross-sectional study. Patients with newly diagnosed exudative macular degeneration are classified into PCV, age-related macular degeneration (AMD), and retinal angiomatous proliferation. Polypoidal choroidal vasculopathy is further classified into two subtypes depending on the presence (Type 1: polypoidal choroidal neovascularization) or absence (Type 2: typical PCV) of feeder vessels on indocyanine green angiography...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28150038/choroidal-structures-in-polypoidal-choroidal-vasculopathy-neovascular-age-related-maculopathy-and-healthy-eyes-determined-by-binarization-of-swept-source-optical-coherence-tomographic-images
#5
Malini Bakthavatsalam, Danny Siu-Chun Ng, Frank Hiu-Ping Lai, Fang Yao Tang, Mårten Erik Brelén, Chi Wai Tsang, Timothy Yuk-Yau Lai, Carol Yim-Lui Cheung
PURPOSE: To evaluate quantitatively the choroidal vascularity in polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (AMD) patients compared to healthy controls. METHODS: All eyes underwent swept source optical coherence tomography (OCT), and choroidal images were binarized into blood vessels lumen and stroma. The choroidal vascular index (CVI) was defined as the ratio of luminal area (LA) over total choroidal area of the subfoveal region with a width of 1500 μm...
February 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28145972/detailed-characterization-of-choroidal-morphologic-and-vascular-features-in-age-related-macular-degeneration-and-polypoidal-choroidal-vasculopathy
#6
Preeti Gupta, Daniel Shu Wei Ting, Sri Gowtham Thakku, Tien-Yin Wong, Ching-Yu Cheng, Edmund Wong, Ranjana Mathur, Doric Wong, Ian Yeo, Chui Ming Gemmy Cheung
PURPOSE: To characterize and compare morphologic and vascular features of the choroid in patients with typical age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) and to determine if PCV subtypes can be identified based on these choroidal features. METHODS: Choroidal features of patients with AMD and PCV recruited from the prospectively planned Asian AMD Phenotyping Study were analyzed. Patients underwent choroidal imaging using spectral-domain optical coherence tomography with enhanced depth imaging...
January 31, 2017: Retina
https://www.readbyqxmd.com/read/28120909/systemic-ocular-and-genetic-risk-factors-for-age-related-macular-degeneration-and-polypoidal-choroidal-vasculopathy-in-singaporeans
#7
Chui Ming Gemmy Cheung, Augustinus Laude, Ian Yeo, Shu-Pei Tan, Qiao Fan, Ranjana Mathur, Shu Yen Lee, Choi Mun Chan, Gavin Tan, Tock Han Lim, Ching-Yu Cheng, Tien Yin Wong
To examine the association of systemic, ocular and genetic risk factors in neovascular age-related macular degeneration (nAMD) in a large cohort of Asian patients, and to further compare risk factors between those with typical AMD and polypoidal choroidal vasculoapthy (PCV) subtypes. We recruited 456 cases and 1,824 controls matched for age, gender and ethnicity. Data on systemic and ocular risk factors were collected on questionnaires. In a subgroup of subjects, we included genetic data on four AMD-associated single nucleotide polymorphisms (SNPs)...
January 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28008222/evaluation-of-peripheral-fundus-autofluorescence-in-eyes-with-wet-age-related-macular-degeneration
#8
Tetsuyuki Suetsugu, Aki Kato, Munenori Yoshida, Tsutomu Yasukawa, Akiko Nishiwaki, Norio Hasegawa, Hideaki Usui, Yuichiro Ogura
PURPOSE: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument. PATIENTS AND METHODS: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27828911/characterization-and-differentiation-of-polypoidal-choroidal-vasculopathy-using-swept-source-optical-coherence-tomography-angiography
#9
Chui Ming Gemmy Cheung, Yasuo Yanagi, Aditi Mohla, Shu Yen Lee, Ranjana Mathur, Choi Mun Chan, Ian Yeo, Tien Yin Wong
PURPOSE: To determine the correlation and agreement between swept-source optical coherence tomography angiography (SS-OCT-A) with fluorescein angiography (FA), indocyanine green angiography (ICGA) and spectral domain OCT (SD-OCT) in characterizing polypoidal choroidal vasculopathy (PCV) and in differentiating eyes with typical age-related macular degeneration (t-AMD). METHODS: This study included 32 and 54 eyes with t-AMD and PCV, respectively, who underwent SS-OCT-A, SD-OCT, fluorescein angiography, and indocyanine green angiography...
November 8, 2016: Retina
https://www.readbyqxmd.com/read/27660164/efficacy-of-intravitreal-aflibercept-in-japanese-patients-with-exudative-age-related-macular-degeneration
#10
Masaaki Saito, Mariko Kano, Kanako Itagaki, Tetsuju Sekiryu
PURPOSE: To clarify the efficacy of aflibercept for treating exudative age-related macular degeneration (AMD). METHODS: We prospectively studied 47 eyes with AMD. Forty-seven patients (mean age 72.2 years) received three consecutive monthly intravitreal aflibercept injections followed by an injection every 2 months until 12 months. The primary outcome was the 12-month visual results compared with baseline; the secondary outcomes were the prevalence of geography atrophy (GA), a dry macula at month 12, and anatomic changes on optical coherence tomography...
January 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27637783/a-perspective-on-the-nature-and-frequency-of-pigment-epithelial-detachments
#11
Anna C S Tan, Daniel Simhaee, Chandrakumar Balaratnasingam, Kunal K Dansingani, Lawrence A Yannuzzi
PURPOSE: To describe and compare the clinical and imaging characteristics of pigment epithelial detachments (PEDs) in age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV) and central serous chorioretinopathy (CSC) as seen in a clinical setting of a tertiary retinal practice. DESIGN: A perspective supported by clinical and imaging characteristics of a consecutive, cohort of patients with strictly defined PEDs. RESULTS: 174 eyes of 113 patients with PEDs were studied with comprehensive clinical retinal examination and multi-modal imaging; PEDs were differentiated into non-vascularized and vascularized forms with 3 main underlying etiologies: AMD (76%), PCV (9%) and CSC (3%)...
September 13, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27596850/investigation-of-precursor-lesions-of-polypoidal-choroidal-vasculopathy-using-contralateral-eye-findings
#12
Se Woong Kang, Hoyoung Lee, Kunho Bae, Joo Young Shin, Sang Jin Kim, Jong Min Kim
PURPOSE: The purpose was to investigate precursor lesions of polypoidal choroidal vasculopathy (PCV). METHODS: This cross-sectional study involved 276 unaffected contralateral eyes from unilateral PCV patients (Group 1), unilateral typical exudative age-related macular degeneration (AMD) patients (Group 2), and unilateral epiretinal membrane patients (Group 3) as age-matched controls. Grayish-yellow sub-retinal or sub-retinal-pigment-epithelial deposits larger than 63 μm in size with irregular but discrete margins were defined as drusen-like deposits (DLDs)...
February 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27485722/the-impact-of-typical-neovascular-age-related-macular-degeneration-and-polypoidal-choroidal-vasculopathy-on-vision-related-quality-of-life-in-asian-patients
#13
Eva K Fenwick, Chui Ming Gemmy Cheung, Peng Guan Ong, Gavin Tan, Shu Yen Lee, Ian Yeo, Ching Yu Cheng, Tien Y Wong, Ecosse L Lamoureux
AIMS: To determine the impact of neovascular age-related macular degeneration (nAMD) on vision-related quality of life (VRQoL) in an Asian population. METHODS: In this cross-sectional study, 162 subjects with nAMD from the Asian AMD Phenotyping Study and 105 randomly sampled age-matched and gender-matched controls from the population-based Singapore Chinese Eye Study were recruited. nAMD was categorised as either polypoidal choroidal vasculopathy (PCV) or 'typical' AMD (tAMD)...
August 2, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27456843/radiating-hemorrhage-in-exudative-age-related-macular-degeneration
#14
Jae Hui Kim, Young Suk Chang, Jong Woo Kim, Tae Gon Lee, Chul Gu Kim, Dong Won Lee
PURPOSE: To investigate the characteristics of radiating hemorrhage secondary to exudative age-related macular degeneration (AMD) and its clinical significance. METHODS: This retrospective, observational case series included 288 eyes of 288 patients who initially presented with submacular hemorrhage secondary to exudative AMD. First, we estimated the incidence of radiating hemorrhage; we then compared the incidence of polypoidal choroidal vasculopathy (PCV) compared with that of the other subtypes of AMD...
November 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27412442/the-role-of-optical-coherence-tomography-angiography-in-fundus-vascular-abnormalities
#15
Shanshan Yu, Jing Lu, Di Cao, Ruyuan Liu, Bingqian Liu, Tao Li, Yan Luo, Lin Lu
BACKGROUND: To evaluate the role of optical coherence tomography angiography (OCTA) in observation of fundus vascular abnormalities. METHODS: Patients (n = 50, 10 in each group) with fundus disorders including branch retinal vein occlusion (BRVO), non-proliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR), exudative age-related macular degeneration (AMD), and polypoidal choroidal vasculopathy (PCV) were examined. They underwent imaging of OCTA and fluorescein angiography/indocyanine green angiography...
July 13, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27338780/htra1-promoter-variant-differentiates-polypoidal-choroidal-vasculopathy-from-exudative-age-related-macular-degeneration
#16
Tsz Kin Ng, Xiao Ying Liang, Timothy Y Y Lai, Li Ma, Pancy O S Tam, Jian Xiong Wang, Li Jia Chen, Haoyu Chen, Chi Pui Pang
Exudative age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) share similar abnormal choroidal vasculature, but responses to treatments are different. In this study, we sequenced the whole HTRA1 gene and its promoter by direct sequencing in a Hong Kong Chinese PCV cohort. We identified rs11200638, c.34delCinsTCCT, c.59C>T, rs1049331 and rs2293870 significantly associated with PCV. Notably, rs2672598 was significantly associated with exudative AMD (p = 1.31 × 10(-4)) than PCV (p = 0...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27307700/one-year-outcome-of-intravitreal-aflibercept-injection-for-age-related-macular-degeneration-resistant-to-ranibizumab-rapid-morphologic-recovery-and-subsequent-visual-improvement
#17
Toshiaki Hirakata, Kaoru Fujinami, Ken Watanabe, Mariko Sasaki, Toru Noda, Kunihiko Akiyama
OBJECTIVE: To describe the 1-year efficacy of aflibercept in Japanese patients with age-related macular degeneration (AMD) who were resistant to ranibizumab treatment. DESIGN: Retrospective case series. PARTICIPANTS: Fourteen consecutive eyes of 14 patients with AMD were enrolled who had no substantial response or developed resistance to intravitreal ranibizumab injections. METHODS: All patients were subcategorized into one of two subtypes of AMD: seven patients with occult choroidal neovascularization (CNV) and seven with polypoidal choroidal vasculopathy (PCV)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27266510/t-helper-associated-cytokines-expression-by-peripheral-blood-mononuclear-cells-in-patients-with-polypoidal-choroidal-vasculopathy-and-age-related-macular-degeneration
#18
Ying Yu, Xiang Rong Ren, Feng Wen, Hui Chen, Shao Bo Su
BACKGROUND: Immune responses play a key role in the pathogenesis and progression of polypoidal choroidal vasculopath (PCV) and age-related macular degeneration (AMD). In this study, we determined the Th cell-associated immune responses by measuring the cytokine expression of peripheral blood mononuclear cells (PBMC) in both PCV and neovascular AMD (nAMD) patients. METHODS: Twenty-seven nAMD patients, 33 PCV patients and a gender- and age-matched group of 18 healthy individuals were involved in this study...
June 7, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27247519/optical-coherence-tomography-based-diagnosis-of-polypoidal-choroidal-vasculopathy-in-korean-patients
#19
Young Suk Chang, Jae Hui Kim, Jong Woo Kim, Tae Gon Lee, Chul Gu Kim
PURPOSE: To evaluate the efficacy of an optical coherence tomography (OCT)-based diagnosis of polypoidal choroidal vasculopathy (PCV) in Korean patients. METHODS: This retrospective, observational case series included 263 eyes of 263 patients (147 eyes with PCV and 116 eyes with typical exudative, age-related macular degeneration [AMD]) who had been diagnosed with treatment naïve exudative AMD. Eyes with three or more of the following OCT findings were diagnosed with PCV: multiple retinal pigment epithelial detachment (RPED), a sharp RPED peak, an RPED notch, a hyporeflective lumen representing polyps, and hyperreflective intraretinal hard exudates...
June 2016: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/27164756/-age-related-macular-degeneration-in-the-japanese
#20
Nagahisa Yoshimura
Age-related macular degeneration (AMD) in the Japanese often shows different clinical features from those described in Caucasians. For example, we often observe choroidal neovascularization (CNV) in elderly patients without drusen in the fundus. The high incidence of polypoidal choroidal vasculopathy (PCV) in AMD among Japanese is well-known. The reason why such differences occur in clinical manifestations of AMD has been one of my main interests. In this review article, I will discuss the characteristics of AMD in the Japanese population, as found in our recent study...
March 2016: Nippon Ganka Gakkai Zasshi
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