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Masaaki Saito, Mariko Kano, Kanako Itagaki, Tetsuju Sekiryu
PURPOSE: To clarify the efficacy of aflibercept for treating exudative age-related macular degeneration (AMD). METHODS: We prospectively studied 47 eyes with AMD. Forty-seven patients (mean age 72.2 years) received three consecutive monthly intravitreal aflibercept injections followed by an injection every 2 months until 12 months. The primary outcome was the 12-month visual results compared with baseline; the secondary outcomes were the prevalence of geography atrophy (GA), a dry macula at month 12, and anatomic changes on optical coherence tomography...
September 22, 2016: Japanese Journal of Ophthalmology
Anna C S Tan, Daniel Simhaee, Chandrakumar Balaratnasingam, Kunal K Dansingani, Lawrence A Yannuzzi
PURPOSE: To describe and compare the clinical and imaging characteristics of pigment epithelial detachments (PEDs) in age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PCV) and central serous chorioretinopathy (CSC) as seen in a clinical setting of a tertiary retinal practice. DESIGN: A perspective supported by clinical and imaging characteristics of a consecutive, cohort of patients with strictly defined PEDs. RESULTS: 174 eyes of 113 patients with PEDs were studied with comprehensive clinical retinal examination and multi-modal imaging; PEDs were differentiated into non-vascularized and vascularized forms with 3 main underlying etiologies: AMD (76%), PCV (9%) and CSC (3%)...
September 13, 2016: American Journal of Ophthalmology
Se Woong Kang, Hoyoung Lee, Kunho Bae, Joo Young Shin, Sang Jin Kim, Jong Min Kim
PURPOSE: The purpose was to investigate precursor lesions of polypoidal choroidal vasculopathy (PCV). METHODS: This cross-sectional study involved 276 unaffected contralateral eyes from unilateral PCV patients (Group 1), unilateral typical exudative age-related macular degeneration (AMD) patients (Group 2), and unilateral epiretinal membrane patients (Group 3) as age-matched controls. Grayish-yellow sub-retinal or sub-retinal-pigment-epithelial deposits larger than 63 μm in size with irregular but discrete margins were defined as drusen-like deposits (DLDs)...
September 5, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Eva K Fenwick, Chui Ming Gemmy Cheung, Peng Guan Ong, Gavin Tan, Shu Yen Lee, Ian Yeo, Ching Yu Cheng, Tien Y Wong, Ecosse L Lamoureux
AIMS: To determine the impact of neovascular age-related macular degeneration (nAMD) on vision-related quality of life (VRQoL) in an Asian population. METHODS: In this cross-sectional study, 162 subjects with nAMD from the Asian AMD Phenotyping Study and 105 randomly sampled age-matched and gender-matched controls from the population-based Singapore Chinese Eye Study were recruited. nAMD was categorised as either polypoidal choroidal vasculopathy (PCV) or 'typical' AMD (tAMD)...
August 2, 2016: British Journal of Ophthalmology
Jae Hui Kim, Young Suk Chang, Jong Woo Kim, Tae Gon Lee, Chul Gu Kim, Dong Won Lee
PURPOSE: To investigate the characteristics of radiating hemorrhage secondary to exudative age-related macular degeneration (AMD) and its clinical significance. METHODS: This retrospective, observational case series included 288 eyes of 288 patients who initially presented with submacular hemorrhage secondary to exudative AMD. First, we estimated the incidence of radiating hemorrhage; we then compared the incidence of polypoidal choroidal vasculopathy (PCV) compared with that of the other subtypes of AMD...
July 25, 2016: Japanese Journal of Ophthalmology
Shanshan Yu, Jing Lu, Di Cao, Ruyuan Liu, Bingqian Liu, Tao Li, Yan Luo, Lin Lu
BACKGROUND: To evaluate the role of optical coherence tomography angiography (OCTA) in observation of fundus vascular abnormalities. METHODS: Patients (n = 50, 10 in each group) with fundus disorders including branch retinal vein occlusion (BRVO), non-proliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR), exudative age-related macular degeneration (AMD), and polypoidal choroidal vasculopathy (PCV) were examined. They underwent imaging of OCTA and fluorescein angiography/indocyanine green angiography...
2016: BMC Ophthalmology
Tsz Kin Ng, Xiao Ying Liang, Timothy Y Y Lai, Li Ma, Pancy O S Tam, Jian Xiong Wang, Li Jia Chen, Haoyu Chen, Chi Pui Pang
Exudative age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) share similar abnormal choroidal vasculature, but responses to treatments are different. In this study, we sequenced the whole HTRA1 gene and its promoter by direct sequencing in a Hong Kong Chinese PCV cohort. We identified rs11200638, c.34delCinsTCCT, c.59C>T, rs1049331 and rs2293870 significantly associated with PCV. Notably, rs2672598 was significantly associated with exudative AMD (p = 1.31 × 10(-4)) than PCV (p = 0...
2016: Scientific Reports
Toshiaki Hirakata, Kaoru Fujinami, Ken Watanabe, Mariko Sasaki, Toru Noda, Kunihiko Akiyama
OBJECTIVE: To describe the 1-year efficacy of aflibercept in Japanese patients with age-related macular degeneration (AMD) who were resistant to ranibizumab treatment. DESIGN: Retrospective case series. PARTICIPANTS: Fourteen consecutive eyes of 14 patients with AMD were enrolled who had no substantial response or developed resistance to intravitreal ranibizumab injections. METHODS: All patients were subcategorized into one of two subtypes of AMD: seven patients with occult choroidal neovascularization (CNV) and seven with polypoidal choroidal vasculopathy (PCV)...
2016: Clinical Ophthalmology
Ying Yu, Xiang Rong Ren, Feng Wen, Hui Chen, Shao Bo Su
BACKGROUND: Immune responses play a key role in the pathogenesis and progression of polypoidal choroidal vasculopath (PCV) and age-related macular degeneration (AMD). In this study, we determined the Th cell-associated immune responses by measuring the cytokine expression of peripheral blood mononuclear cells (PBMC) in both PCV and neovascular AMD (nAMD) patients. METHODS: Twenty-seven nAMD patients, 33 PCV patients and a gender- and age-matched group of 18 healthy individuals were involved in this study...
2016: BMC Ophthalmology
Young Suk Chang, Jae Hui Kim, Jong Woo Kim, Tae Gon Lee, Chul Gu Kim
PURPOSE: To evaluate the efficacy of an optical coherence tomography (OCT)-based diagnosis of polypoidal choroidal vasculopathy (PCV) in Korean patients. METHODS: This retrospective, observational case series included 263 eyes of 263 patients (147 eyes with PCV and 116 eyes with typical exudative, age-related macular degeneration [AMD]) who had been diagnosed with treatment naïve exudative AMD. Eyes with three or more of the following OCT findings were diagnosed with PCV: multiple retinal pigment epithelial detachment (RPED), a sharp RPED peak, an RPED notch, a hyporeflective lumen representing polyps, and hyperreflective intraretinal hard exudates...
June 2016: Korean Journal of Ophthalmology: KJO
Nagahisa Yoshimura
Age-related macular degeneration (AMD) in the Japanese often shows different clinical features from those described in Caucasians. For example, we often observe choroidal neovascularization (CNV) in elderly patients without drusen in the fundus. The high incidence of polypoidal choroidal vasculopathy (PCV) in AMD among Japanese is well-known. The reason why such differences occur in clinical manifestations of AMD has been one of my main interests. In this review article, I will discuss the characteristics of AMD in the Japanese population, as found in our recent study...
March 2016: Nippon Ganka Gakkai Zasshi
Chee Wai Wong, Yasuo Yanagi, Won-Ki Lee, Yuichiro Ogura, Ian Yeo, Tien Yin Wong, Chui Ming Gemmy Cheung
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly people globally. It is estimated that there will be more Asians with AMD than the rest of the world combined by 2050. In Asian populations, polypoidal choroidal vasculopathy (PCV) is a common subtype of exudative AMD, while choroidal neovascularization secondary to AMD (CNV-AMD) is the typical subtype in Western populations. The two subtypes share many common clinical features and risk factors, but also have different epidemiological and clinical characteristics, natural history and treatment outcomes that point to distinct pathophysiological processes...
July 2016: Progress in Retinal and Eye Research
Lulin Huang, Houbin Zhang, Ching-Yu Cheng, Feng Wen, Pancy O S Tam, Peiquan Zhao, Haoyu Chen, Zheng Li, Lijia Chen, Zhengfu Tai, Kenji Yamashiro, Shaoping Deng, Xianjun Zhu, Weiqi Chen, Li Cai, Fang Lu, Yuanfeng Li, Chui-Ming G Cheung, Yi Shi, Masahiro Miyake, Yin Lin, Bo Gong, Xiaoqi Liu, Kar-Seng Sim, Jiyun Yang, Keisuke Mori, Xiongzhe Zhang, Peter D Cackett, Motokazu Tsujikawa, Kohji Nishida, Fang Hao, Shi Ma, He Lin, Jing Cheng, Ping Fei, Timothy Y Y Lai, Sibo Tang, Augustinus Laude, Satoshi Inoue, Ian Y Yeo, Yoichi Sakurada, Yu Zhou, Hiroyuki Iijima, Shigeru Honda, Chuntao Lei, Lin Zhang, Hong Zheng, Dan Jiang, Xiong Zhu, Tien-Ying Wong, Chiea-Chuen Khor, Chi-Pui Pang, Nagahisa Yoshimura, Zhenglin Yang
Polypoidal choroidal vasculopathy (PCV), a subtype of 'wet' age-related macular degeneration (AMD), constitutes up to 55% of cases of wet AMD in Asian patients. In contrast to the choroidal neovascularization (CNV) subtype, the genetic risk factors for PCV are relatively unknown. Exome sequencing analysis of a Han Chinese cohort followed by replication in four independent cohorts identified a rare c.986A>G (p.Lys329Arg) variant in the FGD6 gene as significantly associated with PCV (P = 2.19 × 10(-16), odds ratio (OR) = 2...
June 2016: Nature Genetics
A Ozkaya, C Alagoz, R Garip, Z Alkin, I Perente, A T Yazici, M Taskapili
PurposeTo evaluate the neovascular age-related macular degeneration (nAMD) in patients who were morphologically poor responders to intravitreal ranibizumab (IVR) treatment using indocyanine green angiography (ICGA) for further investigation.MethodsThis was a cross-sectional, retrospective study. The patients with an initial diagnosis of nAMD who made through the clinical examination, optical coherence tomography, and fluorescein angiography imaging, and were treated with at least three monthly IVR injections that resulted with a morphological poor response, were included...
July 2016: Eye
J R Aronés-Santivañez, A Dyrda, I Alarcón Valero
OBJECTIVE: To present the case of simultaneous presentation of polypoidal choroidal vasculopathy (PCV) and aged-related macular degeneration (AMD). CASE REPORT: An 83-year-old woman presented with decreased vision in the left eye (LE). In the examination there was an orange peripapillary lesion surrounded by lipid exudates and another subfoveal greyish lesion in the LE. Disciform scarring was observed in the right eye. Fluorescein angiography showed a classic neovascular membrane in in the LE fovea...
March 30, 2016: Archivos de la Sociedad Española de Oftalmología
Akira Obana, Yuko Gohto, Takahiko Seto
PURPOSE: To investigate the long-term effectiveness of as-needed anti-vascular endothelial growth factor therapy on age-related macular degeneration (AMD). SUBJECTS AND METHODS: The number of treatments, treatment period, visual acuity and morphological changes were investigated retrospectively in 257 eyes of 248 patients (189 men and 59 women, mean age ± SD; 71.1 ± 9.2 years old) who were followed up for two years and more. Re-treatment was mainly decided based on patient's will...
February 2016: Nippon Ganka Gakkai Zasshi
Jae Hui Kim, Tae Gon Lee, Young Suk Chang, Chul Gu Kim, Sung Won Cho
PURPOSE: To compare, in neovascular age-related macular degeneration (AMD) patients, short-term choroidal thickness changes in eyes treated using ranibizumab with those in eyes treated using aflibercept. METHODS: This retrospective, observational study included 240 eyes from 240 patients who had been diagnosed with treatment-naive neovascular AMD and treated using three monthly injections of either ranibizumab (ranibizumab group) or aflibercept (aflibercept group)...
March 7, 2016: British Journal of Ophthalmology
Yorihisa Kitagawa, Hiroyuki Shimada, Ryusaburo Mori, Kouji Tanaka, Mitsuko Yuzawa
PURPOSE: To investigate the efficacy of intravitreal injection of recombinant tissue plasminogen activator (rt-PA), ranibizumab, and gas without vitrectomy for submacular hemorrhage. DESIGN: Prospective, interventional, consecutive case series. PARTICIPANTS: Twenty consecutive patients (20 eyes) with submacular hemorrhage secondary to exudative age-related macular degeneration (AMD) or polypoidal choroidal vasculopathy (PCV). METHODS: Ranibizumab, rt-PA (25 μg/0...
June 2016: Ophthalmology
Yoichi Sakurada, Seigo Yoneyama, Atsushi Sugiyama, Naohiko Tanabe, Wataru Kikushima, Fumihiko Mabuchi, Atsuki Kume, Takeo Kubota, Hiroyuki Iijima
OBJECTIVE: To investigate the prevalence and genetic characteristics of geographic atrophy (GA) among elderly Japanese with advanced age-related macular degeneration (AMD) in a clinic-based study. METHODS: Two-hundred and ninety consecutive patients with advanced AMD were classified into typical neovascular AMD, polypoidal choroidal vasculopathy (PCV), retinal angiomatous proliferation (RAP) or geographic atrophy (GA). Genetic variants of ARMS2 A69S (rs10490924) and CFH I62V (rs800292) were genotyped using TaqMan Genotyping Assays...
2016: PloS One
Judith Lechner, Mei Chen, Ruth E Hogg, Levente Toth, Giuliana Silvestri, Usha Chakravarthy, Heping Xu
BACKGROUND: The aim of this study was to investigate the plasma levels of complement C3a, C4a, and C5a in different types of neovascular age-related macular degeneration (nAMD) and whether the levels were related to patients' responsiveness to anti-VEGF therapy. RESULTS: Ninety-six nAMD patients (including 61 with choroidal neovascularisation (CNV), 17 with retinal angiomatous proliferation (RAP), 14 with polypoidal choroidal vasculopathy (PCV) and 4 unclassified patients) and 43 controls were recruited to this case-control study...
2016: Immunity & Ageing: I & A
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