keyword
https://read.qxmd.com/read/38177669/structural-basis-for-partial-agonism-in-5-ht-3a-receptors
#21
JOURNAL ARTICLE
Kevin Felt, Madeleine Stauffer, Leslie Salas-Estrada, Peter R Guzzo, Dejian Xie, Jinkun Huang, Marta Filizola, Sudha Chakrapani
Hyperactivity of serotonin 3 receptors (5-HT3 R) underlies pathologies associated with irritable bowel syndrome and chemotherapy-induced nausea and vomiting. Setrons, a class of high-affinity competitive antagonists, are used in the treatment of these conditions. Although generally effective for chemotherapy-induced nausea and vomiting, the use of setrons for treating irritable bowel syndrome has been impaired by adverse side effects. Partial agonists are now being considered as an alternative strategy, with potentially less severe side effects than full antagonists...
January 4, 2024: Nature Structural & Molecular Biology
https://read.qxmd.com/read/38163664/role-of-5-hydroxytryptamine-type-3-receptors-in-the-regulation-of-anxiety-reactions
#22
JOURNAL ARTICLE
Yinan DU, Zhiwei Li, Yukui Zhao, Jing Han, Weiping Hu, Zhiqiang Liu
5-Hydroxytryptamine (5-HT) type 3 receptor (5-HT3 R) is the only type of ligand-gated ion channel in the 5-HT receptor family. Through the high permeability of Na+ , K+ , and Ca2+ and activation of subsequent voltage-gated calcium channels (VGCCs), 5-HT3 R induces a rapid increase of neuronal excitability or the release of neurotransmitters from axon terminals in the central nervous system (CNS). 5-HT3 Rs are widely expressed in the medial prefrontal cortex (mPFC), amygdala (AMYG), hippocampus (HIP), periaqueductal gray (PAG), and other brain regions closely associated with anxiety reactions...
January 15, 2024: Journal of Zhejiang University. Science. B
https://read.qxmd.com/read/38159070/acupuncture-for-patients-with-insomnia-and-predictors-of-treatment-response-a-chart-review
#23
JOURNAL ARTICLE
Yujin Choi, Duk-Jong Yu, Kee Chul Ha, Jong-Min Min, Woon-Yong Choi, Dae-Sang Yun, Bum-Hee Kwak, Seung-Gyeom Kim, Jong-Wuk Yoon, Hang-Ki Kim, Dong-Kwan Lim, Kyung-Bae Jeon, Seong-Rok Kim, Sang-Yoon Lee, Sungha Kim
BACKGROUND: Acupuncture is a potentially effective non-pharmacological treatment for insomnia. OBJECTIVE: We observed the responses of patients with insomnia to acupuncture in routine clinical practice. In addition, we explored patient characteristics that might affect the treatment response to acupuncture for insomnia. METHODS: Medical records of patients with insomnia in a Korean medicine clinic with baseline Insomnia Severity Index (ISI) scores ⩾8 and Pittsburgh Sleep Quality Index (PSQI) scores ⩾5 were reviewed...
December 30, 2023: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://read.qxmd.com/read/38145979/palonosetron-for-prevention-of-delayed-chemotherapy-induced-nausea-and-vomiting-in-pediatric-patients-a-meta-analysis
#24
JOURNAL ARTICLE
Atsushi Yamaguchi, Yoshitaka Saito, Yoh Takekuma, Mitsuru Sugawara
PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) are common adverse events in patients undergoing emetogenic chemotherapy. Palonosetron, a second-generation 5-hydroxytryptamine-3 receptor antagonist (5-HT3 RA), has demonstrated non-inferiority to first-generation 5-HT3 RAs for CINV in pediatric patients. Although palonosetron has a long half-life and prolonged antiemetic action, its efficacy against delayed CINV in pediatric patients is not well understood. Therefore, this meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the efficacy of palonosetron for delayed CINV in pediatric patients...
December 26, 2023: Supportive Care in Cancer
https://read.qxmd.com/read/38127246/2023-updated-mascc-esmo-consensus-recommendations-prevention-of-nausea-and-vomiting-following-high-emetic-risk-antineoplastic-agents
#25
JOURNAL ARTICLE
Jørn Herrstedt, L Celio, P J Hesketh, L Zhang, R Navari, A Chan, M Saito, R Chow, M Aapro
PURPOSE: This systematic review updates the MASCC/ESMO recommendations for high-emetic-risk chemotherapy (HEC) published in 2016-2017. HEC still includes cisplatin, carmustine, dacarbazine, mechlorethamine, streptozocin, and cyclophosphamide in doses of > 1500 mg/m2 and the combination of cyclophosphamide and an anthracycline (AC) in women with breast cancer. METHODS: A systematic review report following the PRISMA guidelines of the literature from January 1, 2015, until February 1, 2023, was performed...
December 21, 2023: Supportive Care in Cancer
https://read.qxmd.com/read/38114821/2023-updated-mascc-esmo-consensus-recommendations-prevention-of-nausea-and-vomiting-following-moderately-emetic-risk-antineoplastic-agents
#26
JOURNAL ARTICLE
Florian Scotté, Lee Schwartzberg, Hirotoshi Lihara, Matti Aapro, Richard Gralla, Paul J Hesketh, Karin Jordan, Ronald Chow, Jørn Herrstedt
PURPOSE: Review the literature to update the MASCC guidelines from 2015 for controlling nausea and vomiting with systemic cancer treatment of moderate emetic potential. METHODS: A systematic literature review was completed using Medline, Embase, and Scopus databases. The literature search was done from June 2015 to January 2023 of the management of antiemetic prophylaxis for anticancer therapy of moderate emetic potential. RESULTS: Of 342 papers identified, 19 were relevant to update recommendations about managing antiemetic prophylaxis for systemic cancer treatment regimens of moderate emetic potential...
December 20, 2023: Supportive Care in Cancer
https://read.qxmd.com/read/38111988/alterations-in-descending-brain-spinal-pathways-regulating-colorectal-motility-in-a-rat-model-of-parkinson-s-disease
#27
JOURNAL ARTICLE
Tomoya Sawamura, Natsufu Yuki, Kanae Aoki, Kazuhiro Horii, Yuuki Horii, Kiyotada Naitou, Shumpei Tsukamoto, Takahiko Shiina, Yasutake Shimizu
Patients with Parkinson's disease (PD) often have constipation. It is assumed that a disorder of the regulatory mechanism of colorectal motility by the central nervous system is involved in the constipation, but this remains unclear. The aim of this study was to investigate whether central neural pathways can modulate colorectal motility in a rat model of PD. PD model rats were generated by injection of 6-hydroxydopamine into a unilateral medial forebrain bundle and destruction of dopaminergic neurons in the substantia nigra...
December 19, 2023: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://read.qxmd.com/read/38105286/2023-updated-mascc-esmo-consensus-recommendations-prevention-of-nausea-and-vomiting-following-multiple-day-chemotherapy-high-dose-chemotherapy-and-breakthrough-nausea-and-vomiting
#28
JOURNAL ARTICLE
Bernardo Leon Rapoport, Jørn Herrstedt, Rebecca Clark Snow, Venkatraman Radhakrishnan, Mitsue Saito, Rudolph M Navari, Teresa Smit
PURPOSE: This review is an update of the MASCC/ESMO 2015 recommendations for the prophylaxis of acute and delayed nausea and vomiting induced by multiple-day chemotherapy, high-dose chemotherapy, and breakthrough nausea and vomiting. METHODS: A systematic literature search was conducted using PubMed from June 1, 2015, through February 1, 2023. RESULTS: We identified 56 references (16 were duplications or invalid), leaving 40 manuscripts for this search...
December 18, 2023: Supportive Care in Cancer
https://read.qxmd.com/read/38074143/the-preventive-effects-of-ondansetron-on-chemotherapy-induced-nausea-and-vomiting-in-adult-cancer-patients-systematic-review-from-clinicaltrials-gov
#29
Ahmed M Ashour
Purpose: Cancer is a neoplastic transformation that affects tissue. Among the many complications associated with cancer treatment, managing the distressing side effects of chemotherapy-induced nausea and vomiting (CINV) is of main concern. Ondansetron is a selective serotonin 5-HT3 receptor antagonist that has emerged as an essential medication against CINV in adult cancer patients. Ondansetron efficacy and tolerability have made it a primary medication in CINV prophylaxis and treatment regimens. The study aims to offer a detailed overview of ondansetron's effectiveness, safety, and impact on patients' lives, ultimately contributing to the ongoing research to enhance the quality of cancer care...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/38073648/new-characterization-of-dihydroergotamine-receptor-pharmacology-in-the-context-of-migraine-utilization-of-a-%C3%AE-arrestin-recruitment-assay
#30
JOURNAL ARTICLE
Lisa McConnachie, Peter J Goadsby, Robert E Vann, Sutapa Ray, Stephen B Shrewsbury, Sheena K Aurora
INTRODUCTION: Dihydroergotamine mesylate (DHE) is an established effective acute therapy for migraine and is often characterized by its broad receptor pharmacology. Knowledge of DHE pharmacology largely comes from studies employing older methodologies. OBJECTIVE: To assess DHE receptor activity using high-throughput methods to screen for functional ß-arrestin activity at G protein-coupled receptors (GPCRs). METHODS: Functional receptor activities of DHE and sumatriptan succinate (both 10 μM) were screened against 168 GPCRs using the gpcrMAX assay...
2023: Frontiers in Neurology
https://read.qxmd.com/read/38048912/possible-role-of-exercise-therapy-on-depression-effector-neurotransmitters-as-key-players
#31
REVIEW
Hamed Alizadeh Pahlavani
About 280 million people suffer from depression as the most common neurological disorder and the most common cause of death worldwide. Exercise with serotonin released in the brain by the 5-HT3-IGF-1 mechanism can lead to antidepressant effects. Swimming exercise has antidepressant effects by increasing the sensitivity of serotonin 5-HT2 receptors and postsynaptic 5-HT1A receptors, increasing 5-HT and 5HIAA levels, increasing TPH and serotonin, and decreasing inflammatory levels of IFN-γ and TNF-α...
February 29, 2024: Behavioural Brain Research
https://read.qxmd.com/read/38026950/perioperative-utility-of-amisulpride-and-dopamine-receptor-antagonist-antiemetics-a-narrative-review
#32
REVIEW
Murad Elias, Alexa Gombert, Sulaimaan Siddiqui, Sun Yu, Zhaosheng Jin, Sergio Bergese
Despite advances in antiemetics and protocolized postoperative nausea vomiting (PONV) management, it remains one of the most common postoperative adverse events. In patients who developed PONV despite antiemetic prophylaxis, giving a rescue treatment from the same class of medication is known to be of limited efficacy. Given the widespread use of 5-HT3 antagonists as PONV prophylaxis, another class of effective intravenous rescue antiemetic is in dire need, especially when prophylaxis fails, and rescue medication is utilized...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/38013306/efficacy-and-safety-of-aprepitant-containing-triple-therapy-for-the-prevention-and-treatment-of-chemotherapy-induced-nausea-and-vomiting-a-meta-analysis
#33
JOURNAL ARTICLE
Min Zhang, Qing-Li Guo, Ting-Ting Zhang, Min Fu, Heng-Tai Bi, Jun-Yao Zhang, Kai-Li Zou
BACKGROUND: Most cancer patients suffer from the pain of chemotherapy-induced nausea and vomiting (CINV). This meta-analysis was performed to evaluate the efficacy and safety of a regimen consisting of aprepitant, dexamethasone, and 5-HT3 receptor antagonists in the prevention and treatment of CINV. METHODS: A systematic literature search was conducted across multiple databases, including PubMed, EMbase, Cochrane Library, MEDLINE, CENTRAL, HEED, CNKI, Wanfang, and VIP, to identify randomized controlled trials (RCTs) investigating the use of triple therapy (aprepitant, 5-HT3 receptor antagonist, and dexamethasone) to prevent and treat CINV...
November 24, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38012263/efficacy-and-safety-of-5-hydroxytryptamine-3-5-ht3-receptor-antagonists-in-augmentation-with-selective-serotonin-reuptake-inhibitors-ssris-in-the-treatment-of-moderate-to-severe-obsessive-compulsive-disorder-a-systematic-review-and-meta-analysis-of-randomized
#34
JOURNAL ARTICLE
Negin Eissazade, Hesam Mosavari, Shayan Eghdami, Mahsa Boroon, Faria Ashrafi, Mohammadreza Shalbafan
Obsessive-compulsive disorder (OCD) is the fourth most common mental disorder, and selective serotonin reuptake inhibitors (SSRIs) are the cornerstone of its pharmacological treatment. About 40-60% of the cases are treatment-refractory, and this makes searching for second-line treatment necessary. 5-Hydroxytryptamine-3 (5-HT3) antagonists are among the many medications that have been used in augmentation with SSRIs. In this systematic review and meta-analysis, we assessed the efficacy and safety of 5-HT3 receptor antagonists in augmentation with SSRIs in treating moderate to severe OCD...
November 27, 2023: Scientific Reports
https://read.qxmd.com/read/37992787/interleukin-15-alters-hippocampal-synaptic-transmission-and-impairs-episodic-memory-formation-in-mice
#35
JOURNAL ARTICLE
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Cytokines are potent immunomodulators exerting pleiotropic effects in the central nervous system (CNS). They influence neuronal functions and circuit activities with effects on memory processes and behaviors. Here, we unravel a neuromodulatory activity of interleukin-15 (IL-15) in mouse brain. Acute exposure of hippocampal slices to IL-15 enhances gamma-aminobutyricacid (GABA) release and reduces glutamatergic currents, while chronic treatment with IL-15 increases the frequency of hippocampal miniature inhibitory synaptic transmission and impairs memory formation in the novel object recognition (NOR) test...
January 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/37936910/efficacy-and-safety-of-ondansetron-for-morning-sickness-in-pregnancy-a-systematic-review-of-clinical-trials
#36
Ahmed M Ashour
Background: Ondansetron is a selective antagonist of the serotonin 5-HT3 receptor that is commonly used to treat morning sickness. It is estimated that 70%-80% of pregnant women suffer from morning sickness, a condition characterized by nausea and vomiting. However, it is still controversial regarding its safety during pregnancy, and continued research will be necessary to fully understand the risks and benefits associated with its use. Therefore, we aimed to identify and provide details of the efficacy and safety of ondansetron in clinical trials...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37928825/a-suspected-case-of-serotonin-syndrome-induced-by-palonosetron-and-ramosetron-administration
#37
JOURNAL ARTICLE
Yo-Seob Lee, Jae-Woo Yi
Serotonin syndrome occurs when serotonin (5-hydroxytryptamine, 5-HT) levels increase and is accompanied by symptoms of mental status changes, neuromuscular abnormalities, and autonomic hyperactivity. Serotonin receptor 3 antagonists, such as palonosetron or ramosetron, are commonly used for their antiemetic effects during general anesthesia. However, overdosage of these drugs carries a risk of serotonergic toxicity as they increase serum serotonin levels due to inhibition of serotonin reuptake. Serotonin syndrome caused by 5-HT3 antagonists is thought to be caused by the synergistic effects of high doses of serotonergic drugs or the combination of two or more serotonergic drugs with different mechanisms of action...
October 2023: Journal of Exercise Rehabilitation
https://read.qxmd.com/read/37920212/5-7-dimethoxycoumarin-ameliorates-vincristine-induced-neuropathic-pain-potential-role-of-5ht-3-receptors-and-monoamines
#38
JOURNAL ARTICLE
Muhammad Usman, Hurmat Malik, Ahmed Tokhi, Mehreen Arif, Zilli Huma, Khalid Rauf, Robert D E Sewell
Vincristine is the drug of choice for Hodgkin's lymphoma, acute lymphoblastic leukemia, and non-Hodgkin lymphoma. Despite its significant anticancer effects, it causes dose-dependent neuropathy, leading to compulsive dose reduction. The available drugs used for vincristine-induced neuropathic pain (VINP) have a range of safety, efficacy, and tolerability issues prompting a search for new therapies. 5,7-Dimethoxycoumarin (5,7-DMC) also known as citropten, is a natural coumarin found in the essential oils of citrus plants such as lime, lemons, and bergamots, and it possesses both antidepressant and anti-inflammatory effects...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37895936/involvement-of-the-spinal-serotonergic-system-in-the-analgesic-effect-of-6-shogaol-in-oxaliplatin-induced-neuropathic-pain-in-mice
#39
JOURNAL ARTICLE
Juan Gang, Keun-Tae Park, Suyong Kim, Woojin Kim
Oxaliplatin is a chemotherapy drug that can induce severe acute neuropathy in patients within hours of treatment. In our previous study, 10 mg/kg [6]-shogaol (i.p.) significantly alleviated cold and mechanical allodynia induced by a 6 mg/kg oxaliplatin injection (i.p.); however, the precise serotonin-modulatory effect has not been investigated. In this study, we showed that intrathecal injections of NAN-190 (5-HT1A receptor antagonist, 1 µg) and MDL-72222 (5-HT3 receptor antagonist, 15 µg), but not ketanserin (5-HT2A receptor antagonist, 1 µg), significantly blocked the analgesic effect of [6]-shogaol (10 mg/kg, i...
October 15, 2023: Pharmaceuticals
https://read.qxmd.com/read/37889164/photosynthetic-costs-and-impact-on-epidemiological-parameters-associated-with-ht-resistance-genes-in-maize-lines-infected-with-exserohilum-turcicum
#40
JOURNAL ARTICLE
Barbara Ludwig Navarro, Sebastian Streit, Antonio Fernandes Nogueira Junior, Andreas von Tiedemann
Northern corn leaf blight is caused by Exserohilum turcicum , mainly controlled by the use of resistant cultivars. Maize lines carrying individual resistance genes B37 Ht1 , B37 Ht2 , B37 Ht3 and B37 Htn1 express different defense symptoms having impact on the photosynthetic activity, the accumulation of reactive oxygen species and on epidemiological parameters. Plants were inoculated with a race 0 isolate of E. turcicum conferring a compatible interaction with B37 and incompatible interactions with plants carrying resistance genes...
October 27, 2023: Phytopathology
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