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https://www.readbyqxmd.com/read/28229211/multicenter-international-experience-of-532%C3%A2-nm-laser-photo-vaporization-with-greenlight-xps-in-men-with-large-prostates-prostate-volume%C3%A2-%C3%A2-100%C3%A2-cc
#1
Malek Meskawi, Pierre-Alain Hueber, Roger Valdivieso, Franck Bruyere, Vincent Misrai, Georges Fournier, Ravi Munver, Ganesh Sivarajan, Matthew Rutman, Alexis E Te, Bilal Chughtai, Dean Elterman, Tristan Martel, Mounsif Azizi, Pierre I Karakiewicz, Kevin C Zorn
PURPOSE: To evaluate the outcomes and durability of photoselective vaporization of the prostate (PVP) using the XPS-180 system in patients with a large prostate volume (PV) > 100 cc at 4 years of follow-up in a large, multicenter experience. METHODS: 438 men with pre-operative transrectal ultrasound (TRUS) PV > 100 cc were treated in eight experienced centers in Canada, USA, and in France with the Greenlight XPS laser using PVP for the treatment of symptomatic BPH...
February 22, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28229078/systemic-therapy-of-cholangiocarcinoma
#2
REVIEW
Ruben R Plentz, Nisar P Malek
BACKGROUND: Cholangiocarcinoma (CC) is the second most common primary malignant liver disease. During the last decades, various novel therapies have been introduced in the field of oncology; nevertheless, the number of treatment options for CC is still limited. METHODS: In this article, current palliative chemotherapy concepts as well as new drug therapies are outlined. RESULTS: Gemcitabine and cisplatin are the standard treatment of care for patients with inoperable CC...
December 2016: Visceral Medicine
https://www.readbyqxmd.com/read/28229072/cholangiocarcinoma
#3
EDITORIAL
Alfred Königsrainer, Nisar P Malek
No abstract text is available yet for this article.
December 2016: Visceral Medicine
https://www.readbyqxmd.com/read/28227905/a-supervised-learning-rule-for-classification-of-spatiotemporal-spike-patterns
#4
Lilin Guo, Zhenzhong Wang, Malek Adjouadi, Lilin Guo, Zhenzhong Wang, Malek Adjouadi, Lilin Guo, Zhenzhong Wang, Malek Adjouadi
This study introduces a novel supervised algorithm for spiking neurons that take into consideration synapse delays and axonal delays associated with weights. It can be utilized for both classification and association and uses several biologically influenced properties, such as axonal and synaptic delays. This algorithm also takes into consideration spike-timing-dependent plasticity as in Remote Supervised Method (ReSuMe). This paper focuses on the classification aspect alone. Spiked neurons trained according to this proposed learning rule are capable of classifying different categories by the associated sequences of precisely timed spikes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226671/connectivity-maps-of-different-types-of-epileptogenic-patterns
#5
Hoda Rajaei, Mercedes Cabrerizo, Panuwat Janwattanapong, Alberto Pinzon-Ardila, Sergio Gonzalez-Arias, Malek Adjouadi, Hoda Rajaei, Mercedes Cabrerizo, Panuwat Janwattanapong, Alberto Pinzon-Ardila, Sergio Gonzalez-Arias, Malek Adjouadi, Sergio Gonzalez-Arias, Malek Adjouadi, Hoda Rajaei, Panuwat Janwattanapong, Mercedes Cabrerizo, Alberto Pinzon-Ardila
EEG functional connectivity maps, showing the interactions between brain areas in context to the placement of electrodes, were used for the investigation and comparison of three different types of epileptiform activity defined as single spike, spike followed by slow wave and repetitive spike. A nonlinear data-driven method was used to extract connectivity matrices that helped to identify network synchronization based on the number of connections for all brain regions, as represented by the 10-20 EEG system...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226617/application-of-cross-correlated-delay-shift-rule-in-spiking-neural-networks-for-interictal-spike-detection
#6
Lilin Guo, Zhenzhong Wang, Mercedes Cabrerizo, Malek Adjouadi, Lilin Guo, Zhenzhong Wang, Mercedes Cabrerizo, Malek Adjouadi, Mercedes Cabrerizo, Lilin Guo, Zhenzhong Wang, Malek Adjouadi
This study proposes a Cross-Correlated Delay Shift (CCDS) supervised learning rule to train neurons with associated spatiotemporal patterns to classify spike patterns. The objective of this study was to evaluate the feasibility of using the CCDS rule to automate the detection of interictal spikes in electroencephalogram (EEG) data on patients with epilepsy. Encoding is the initial yet essential step for spiking neurons to process EEG patterns. A new encoding method is utilized to convert the EEG signal into spike patterns...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221244/hla-amino-acid-polymorphisms-and-kidney-allograft-survival
#7
Malek Kamoun, Keith P McCullough, Martin Maiers, Marcelo A Fernandez Vina, Hongzhe Li, Valerie Teal, Alan B Leichtman, Robert M Merion
BACKGROUND: The association of HLA mismatching with kidney allograft survival has been well established. We examined whether amino acid mismatches at the antigen recognition site of HLA molecules represent independent and incremental risk factors for kidney graft failure (GF) beyond those mismatches assessed at the antigenic (2-digit) specificity. METHODS: Data on 240,024 kidney transplants performed between 1987 and 2009 were obtained from the Scientific Registry of Transplant Recipients...
February 18, 2017: Transplantation
https://www.readbyqxmd.com/read/28217307/worse-prognosis-of-real-world-patients-with-acute-heart-failure-from-the-czech-ahead-registry-in-comparison-to-patients-from-the-relax-ahf-trial
#8
Jindrich Spinar, Jiri Jarkovsky, Lenka Spinarova, Jiri Vitovec, Ales Linhart, Petr Widimsky, Roman Miklik, Kamil Zeman, Jan Belohlavek, Filip Malek, Cestmir Cihalik, Jiri Spac, Marian Felsoci, Petr Ostadal, Ladislav Dusek, Jiri Kettner, Jan Vaclavik, Simona Littnerova, Zdeněk Monhart, Josef Malek, Jiri Parenica
AIMS: The randomized clinical trial RELAX-AHF demonstrated a positive effect of vasodilator therapy with serelaxin in the treatment of AHF patients. The aim of our study was to compare clinical characteristics and outcomes of patients from the AHEAD registry who met criteria of the RELAX-AHF trial (relax-comparable group) with the same characteristics and outcomes of patients from the AHEAD registry who did not meet those criteria (relax-non-comparable group), and finally with characteristics and outcomes of patients from the RELAX-AHF trial...
February 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28214965/surgical-correction-of-aberrant-right-coronary-anomalies-stranding-an-aortic-commissure-with-and-without-unroofing
#9
Khaled Abdelhady, Samarth Durgam, Chawki Elzein, Michel N Ilbawi, David Rhoiney, Malek G Massad
The technique for successful surgical correction of an anomalous origin of the right coronary artery from the opposite aortic cusp with an aberrant course between the aorta and pulmonary artery is illustrated in a symptomatic 62-year-old woman. The intramural course of the right coronary artery traversed the tip of the commissure between the anterior and posterior leaflets, and its repair entailed unroofing of the intramural segment from inside the aortic intima. This technique required resuspension of the overlying commissure to maintain optimal aortic valve leaflet coaptation and prevent aortic insufficiency...
February 18, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28214899/therapeutic-targeting-of-epithelial-plasticity-programs-focus-on-the-epithelial-mesenchymal-transition
#10
Reem Malek, Hailun Wang, Kekoa Taparra, Phuoc T Tran
Mounting data points to epithelial plasticity programs such as the epithelial-mesenchymal transition (EMT) as clinically relevant therapeutic targets for the treatment of malignant tumors. In addition to the widely realized role of EMT in increasing cancer cell invasiveness during cancer metastasis, the EMT has also been implicated in allowing cancer cells to avoid tumor suppressor pathways during early tumorigenesis. In addition, data linking EMT to innate and acquired treatment resistance further points towards the desire to develop pharmacological therapies to target epithelial plasticity in cancer...
2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28208135/abcb1-and-slco1b3-gene-polymorphisms-and-their-impact-on-digoxin-pharmacokinetics-in-atrial-fibrillation-patients-among-the-tunisian-population
#11
Nejia Tounsi, Imen Trabelsi, Emna Kerkeni, Mohamed Habib Grissa, Nizar Fredj, Adel Sekma, Malek Mzali, Ilhem Hellara, Kamel Monastiri, Wahiba Douki, Semir Nouira
BACKGROUND: Digoxin is a substrate of P-glycoprotein (P-gp) and organic anion transporting polypeptide transporters that are encoded by ABCB1 and SLCO1B3 genes. Genetic polymorphisms in both genes may explain inter-individual variability of serum digoxin concentration (SDC). This study evaluates the possible effect of the most common ABCB1 and SLCO1B3 polymorphisms on SDC after a single oral dose of digoxin in Tunisian atrial fibrillation (AF) patients. METHODS: ABCB1 and SLCO1B3 genotypes were analyzed in 102 patients with AF who received digoxin (0...
February 17, 2017: Pharmacology
https://www.readbyqxmd.com/read/28206674/effects-of-spinal-cord-stimulation-on-cardiac-sympathetic-nerve-activity-in-patients-with-heart-failure
#12
Jan Naar, Deborah Jaye, Cecilia Linde, Petr Neužil, Petr Doškář, Filip Málek, Frieder Braunschweig, Lars H Lund, Lars Mortensen, Bengt Linderoth, Göran Lind, Dianna Bone, Arthur J Scholte, Fred Kueffer, Jodi Koehler, Kambiz Shahgaldi, Otto Lang, Marcus Ståhlberg
BACKGROUND: Spinal cord stimulation (SCS) reduces sympathetic activity in animal models of heart failure with reduced ejection fraction (HF) but limited data exist of SCS in patients with HF. The aim of the present study was to test the primary hypothesis that SCS reduces cardiac sympathetic nerve activity in HF patients. Secondary hypotheses were that SCS improves left ventricular function and dimension, exercise capacity and clinical variables relevant to HF. METHODS: HF patients with a SCS device previously participating in the DEFEAT-HF trial were included in this crossover study with 6-week intervention periods (SCS-ON and SCS-OFF)...
February 16, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28202057/improvement-of-memory-and-learning-by-intracerebroventricular-microinjection-of-t3-in-rat-model-of-ischemic-brain-stroke-mediated-by-upregulation-of-bdnf-and-gdnf-in-ca1-hippocampal-region
#13
Tahmineh Mokhtari, Mohammad Akbari, Fatemeh Malek, Iraj Ragerdi Kashani, Tayebeh Rastegar, Farshid Noorbakhsh, Mahmoud Ghazi-Khansari, Fatemeh Attari, Gholamreza Hassanzadeh
BACKGROUND: Ischemic stroke is a common leading cause of death and disability with lack of effective therapies. In this study, T3 was intra-ventricularly injected to evaluate gene expression and protein concentration of and brain-derived neurotrophic factor (BDNF) and Glial cell-derived neurotrophic factor (GDNF) in hippocampal CA1 region in rat model of brain ischemia/reperfusion (I/R). METHODS: In this study, transient middle cerebral artery occlusion (tMCAo) was used as model of ischemic brain stroke...
February 15, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28202008/relationship-between-abcb1-3435tt-genotype-and-antiepileptic-drugs-resistance-in-epilepsy-updated-systematic-review-and-meta-analysis
#14
Malek Chouchi, Wajih Kaabachi, Hedia Klaa, Kalthoum Tizaoui, Ilhem Ben-Youssef Turki, Lamia Hila
BACKGROUND: Antiepileptic drugs (AEDs) are effective medications available for epilepsy. However, many patients do not respond to this treatment and become resistant. Genetic polymorphisms may be involved in the variation of AEDs response. Therefore, we conducted an updated systematic review and a meta-analysis to investigate the contribution of the genetic profile on epilepsy drug resistance. METHODS: We proceeded to the selection of eligible studies related to the associations of polymorphisms with resistance to AEDs therapy in epilepsy, published from January 1980 until November 2016, using Pubmed and Cochrane Library databases...
February 15, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28198206/nitraria-retusa-fruit-prevents-penconazole-induced-kidney-injury-in-adult-rats-through-modulation-of-oxidative-stress-and-histopathological-changes
#15
Mariem Chaâbane, Mohamed Koubaa, Nejla Soudani, Awatef Elwej, Malek Grati, Kamel Jamoussi, Tahia Boudawara, Semia Ellouze Chaabouni, Najiba Zeghal
CONTEXT: Nitraria retusa (Forssk.) Asch. (Nitrariaceae) is a medicinal plant which produces edible fruits whose antioxidant activity has been demonstrated. OBJECTIVE: The current study elucidates the potential protective effect of N. retusa fruit aqueous extract against nephrotoxicity induced by penconazole, a triazole fungicide, in the kidney of adult rats. MATERIALS AND METHODS: Adult Wistar rats were exposed either to penconazole (67 mg/kg body weight), or to N...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28192848/low-grade-appendiceal-mucinous-neoplasm-lamn-3-year-endoscopic-follow-up-underlines-benign-course-of%C3%A2-lamn-type-1
#16
Thomas Klag, Jan Wehkamp, Hans Bösmüller, Claudius Falch, Jonas Johannink, Nisar P Malek, Andreas Kirschniak, Martin Goetz
Low-grade appendiceal mucinous neoplasms (LAMNs) are neoplastic lesions with potential progression to pseudomyxoma peritonei (PMP). In most cases, diagnosis is made because of suspected acute appendicitis or incidentally by computed tomography (CT). However, incidental diagnosis during colonoscopy is rare. We present the case of a 63-year-old man with a LAMN type 1 lesion, diagnosed at routine colonoscopy for surveillance of ulcerative colitis. Because in earlier surveillance colonoscopies, this lesion was misinterpreted as fecal polution, for the first time, this case describes retrospectively a 3-year endoscopic follow-up of LAMN type 1, underlining the benign course of these kind of lesions compared to type 2 lesions with submucosal infiltration...
February 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28192278/lightweight-3d-cellular-composites-inspired-by-balsa
#17
Sardar Malek, Jordan Raney, Jennifer Lewis, Lorna Gibson
Additive manufacturing technologies offer new ways to fabricate cellular materials with composite cell walls, mimicking the structure and mechanical properties of woods. However, materials limitations and a lack of design tools have confined the usefulness of 3D printed cellular materials. We develop new carbon fiber reinforced, epoxy inks for 3D printing which result in printed materials with longitudinal Young's modulus up to 57 GPa (exceeding the longitudinal modulus of wood cell wall material). To guide the design of hierarchical cellular materials, we developed a parameterized, multi-scale, finite element model...
February 13, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28187375/a-comparative-study-of-nuclear-8-hydroxyguanosine-expression-in-autoimmune-thyroid-diseases-and-papillary-thyroid-carcinoma-and-its-relationship-with-p53-bcl-2-and-ki-67-cancer-related-proteins
#18
Malek Mseddi, Riadh Ben Mansour, Naourez Gouiia, Fatma Mnif, Rabï Bousselaa, Mohamed Abid, Tahia Boudaouara, Hamadi Attia, Saloua Lassoued
PURPOSE: To investigate whether the oxidative stress is involved in the evolution of Graves' disease (GD) and Hashimoto thyroiditis (HT) into Papillary Thyroid Carcinoma (PTC), 8-hydroxy-2'-deoxyguanosine (8-OHdG) and cancer related proteins (Bcl-2, p53 and Ki-67) expressions were evaluated in these pathologies. PATIENTS AND METHODS: Immunohistochemical method was applied on 25 thyroid tissues. Allred score (AS) serving to evaluate the immunostaining is based on a scale from 0 to 8...
June 22, 2016: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28186678/gamma-secretase-inhibitor-ix-gsi-impairs-concomitant-activation-of-notch-and-wnt-beta-catenin-pathways-in-cd44-gastric-cancer-stem-cells
#19
Samarpita Barat, Xi Chen, Khac Cuong Bui, Przemyslaw Bozko, Julian Götze, Matthias Christgen, Till Krech, Nisar P Malek, Ruben R Plentz
Cancer stem cells (CSC) are associated with tumor resistance and are characterized in gastric cancer (GC). Studies have indicated that Notch and wnt-beta-catenin pathways are crucial for CSC development. Using CD44(+) CSCs, we investigated the role of these pathways in GC carcinogenesis. We performed cell proliferation, wound healing, invasion, tumorsphere, and apoptosis assays. Immunoblot analysis of downstream signaling targets of Notch and wnt-beta-catenin were tested after gamma-secretase inhibitor IX (GSI) treatment...
February 3, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28176618/experience-of-liver-transplant-in-patients-diagnosed-with-budd-chiari-syndrome
#20
Syed Muhammad Raza, Saima Zainab, Ali Reza Shamsaeefar, Saman Nikeghbalian, Seyed Ali Malek Hosseini
OBJECTIVES: Budd-Chiari syndrome can lead to fulminant hepatic failure and cirrhosis. The treatment depends on the severity of disease. Liver transplant is a successful treatment option for those with advanced-stage disease. MATERIALS AND METHODS: In this retrospective study, we analyzed all liver transplants conducted for Budd-Chiari syndrome at the organ transplant unit of Shiraz University of Medical Sciences, Iran, from 1993 to January 2016. Overall, 3201 liver transplant procedures were performed...
February 7, 2017: Experimental and Clinical Transplantation
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