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https://www.readbyqxmd.com/read/28436112/chiral-fidelity-in-the-diastereoselective-and-enantiospecific-synthesis-of-indenes-from-axially-chiral-benzylidene-cyclanes
#1
Malek Nechab, Dominique Mouysset, Cyril Tessonnier, Aura Tintaru, Frédéric Dumur, Marion Jean, Nicolas Vanthuyne, Michèle P Bertrand, Didier Siri
Enantioenriched indenes were reached through a chirality conversion strategy using original axially chiral benzylidene cyclanes. Good to high remote diastereocontrol and excellent enantiocontrol were observed in this cascade involving copper-catalyzed homologation of terminal alkynes, in-situ allenoate formation and Alder-ene cyclization..
April 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28431875/protein-oxidation-and-autoantibodies-reactivity-against-malondialdehyde-and-hydrogen-peroxide-modified-thyroid-antigens-in-plasma-of-patients-with-graves-disease-and-hashimoto-thyroiditis
#2
Malek Mseddi, Riadh Ben Mansour, Bochra Gargouri, Fatma Mnif, Samir El Ghawi, Boutheina Hammami, Abdelmonem Ghorbel, Mohamed Abid, Saloua Lassoued
The aim of this study was first to investigate the oxidative proteins modifications in the plasma of both autoimmune thyroid diseases (AITD), Graves' disease (GD) and Hashimoto Thyroiditis (HT). Then, the impact of these oxidative modifications on immune response was evaluated by measuring the reactivity of patients' autoantibodies against malondialdéhyde (MDA) and Hydrogen peroxide (H2O2) modified thyroid antigens (T.Ag) in comparison to native ones. Carbonyl and thiol groups, and MDA-protein adducts were first assessed among 74 AITD patients and 65 healthy controls...
April 18, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28431829/utility-of-the-new-movement-disorder-society-clinical-diagnostic-criteria-for-parkinson-s-disease-applied-retrospectively-in-a-large-cohort-study-of-recent-onset-cases
#3
Naveed Malek, Michael A Lawton, Katherine A Grosset, Nin Bajaj, Roger A Barker, Yoav Ben-Shlomo, David J Burn, Tom Foltynie, John Hardy, Huw R Morris, Nigel M Williams, Nicholas Wood, Donald G Grosset
OBJECTIVE: To examine the utility of the new Movement Disorder Society (MDS) diagnostic criteria in a large cohort of Parkinson's disease (PD) patients. METHODS: Recently diagnosed (<3.5 years) PD cases fulfilling United Kingdom (UK) brain bank criteria in Tracking Parkinson's, a UK multicenter prospective natural history study were assessed by retrospective application of the MDS criteria. RESULTS: In 2000 cases, 1835 (91.7%) met MDS criteria for PD, either clinically established (n = 1261, 63...
April 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28426509/log-transformed-emg-amplitude-power-output-relationship-single-leg-knee-extensor-versus-single-leg-cycle-ergometry
#4
Eric B Noble, Joshua M Pilarski, Harshal K Vora, Jorge M Zuniga, Moh H Malek
Comparing and contrasting motor unit recruitment and activation for the same muscles for multiple versus single-joint exercise may provide a better understanding of neuromuscular fatigue. The purpose of this study, therefore, is to compare the slope and y-intercept terms for the three superficial quadriceps femoris (vastus lateralis, rectus femoris, and vastus medialis) muscles derived from the log-transformed EMG amplitude-power output relationship between the single-leg knee-extensor ergometry and the single-leg cycle ergometry...
April 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28419972/neprilysin-inhibitors-a-new-hope-to-halt-the-diabetic-cardiovascular-and-renal-complications
#5
REVIEW
Vajir Malek, Anil Bhanudas Gaikwad
Diabetes is an enormous and ever-growing calamity and a global public health threat of the 21st century. Besides insulin and oral hypoglycaemic drugs, blockage of the renin-angiotensin system (RAS) denotes a key pharmacotherapy for the management of cardiovascular (CVD) and chronic kidney diseases (CKD), which are the leading causes of disability and death among diabetic patients. Neprilysin (NEP) inhibition, auxiliary to RAS blockage increases the bioavailability of natriuretic peptides and benefits the cardio-renal system...
April 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28419625/meta-analysis-of-interventions-for-posttraumatic-stress-disorder-and-depression-in-adult-survivors-of-mass-violence-in-low-and-middle-income-countries
#6
REVIEW
Nexhmedin Morina, Mina Malek, Angela Nickerson, Richard A Bryant
BACKGROUND: Most survivors of mass violence live in low- and middle-income countries (LMICs). We conducted a meta-analysis of randomized controlled psychotherapy trials for adult posttraumatic stress disorder (PTSD) and/or depression in LMICs. METHODS: We included 18 clinical trials (3,058 participants), in which 25 and 18 treatment arms measured symptoms of PTSD and depression, respectively. RESULTS: Active treatments for PTSD yielded a large aggregated pre-post effect size (g = 1...
April 18, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28408997/endoscopic-balloon-dilatation-of-crohn-s-associated-intestinal-strictures-high-patient-satisfaction-and-long-term-efficacy
#7
Anna Rueda Guzmán, Jan Wehkamp, Andreas Kirschniak, Aline Naumann, Nisar P Malek, Martin Goetz
INTRODUCTION: Stricture formation is a common long-term complication of Crohn's disease. Endoscopic balloon dilatation offers a bowel-sparing treatment option, but long-term outcome and its association with patient-, stricture-, and procedure-related factors is only poorly understood. Patient satisfaction with endoscopic balloon dilatation is largely unknown. METHODS: We performed a retrospective review of all endoscopic balloon dilatation for Crohn's disease-related strictures between January 2005 and January 2013...
December 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28408354/therapeutic-effects-of-argyrin-f-in-pancreatic-adenocarcinoma
#8
Xi Chen, Khac Cuong Bui, Samarpita Barat, Mai Ly Thi Nguyen, Przemyslaw Bozko, Bence Sipos, Markus Kalesse, Nisar P Malek, Ruben R Plentz
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with limited treatment options. The proteasome inhibitor Argyrin A, a cyclic peptide derived from the myxobacterium Archangium gephyra, shows antitumoral activities. We hypothesize that his analogue Argyrin F (AF) may also prevent PDAC progression. We have used PDAC cells and engineered mice (Pdx1-Cre; LSL-KrasG12D; p53 (lox/+)) to assess AF anticancer activity. We analyzed the effect of AF on proliferation and epithelial plasticity using MTT-, wound healing-, invasion-, colony formation-, apoptosis-, cell cycle- and senescence assays...
April 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28405696/-varicella-gastritis-under-immunosuppression-case-report-of-a-woman-after-lung-transplantation-due-to-granulomatosis-with-polyangiitis
#9
S Saman, J-C Henes, D Niepel, H Bosmüller, C R Werner, U M Lauer, N P Malek, T Xenitidis
A 35-year-old woman who had previously undergone a lung transplantation presented with severe abdominal pain and vomiting. The gastroscopy showed diffuse ulcerative gastric lesions. Tests for varicella zoster virus and Epstein-Barr virus via polymerase chain reactions (PCR) on endoscopically obtained gastric biopsies were found to be positive and confirmed varicella gastritis. Intravenous antiviral therapy with acyclovir was administered resulting in a normalization of all clinical symptoms, especially of abdominal pain and inflammation parameters...
April 12, 2017: Der Internist
https://www.readbyqxmd.com/read/28398117/reconstructing-the-times-of-past-and-future-personal-events
#10
Hédi Ben Malek, Fabrice Berna, Arnaud D'Argembeau
Humans have the remarkable ability to mentally travel through past and future times. However, while memory for the times of past events has been much investigated, little is known about how imagined future events are temporally located. Using a think-aloud protocol, we found that the temporal location of past and future events is rarely directly accessed, but instead mostly relies on reconstructive and inferential strategies. References to lifetime periods and factual knowledge (about the self, others, and the world) were most frequently used to determine the temporal location of both past and future events...
April 11, 2017: Memory
https://www.readbyqxmd.com/read/28397792/erratum-connecting-genetic-risk-to-disease-end-points-through-the-human-blood-plasma-proteome
#11
Karsten Suhre, Matthias Arnold, Aditya Mukund Bhagwat, Richard J Cotton, Rudolf Engelke, Johannes Raffler, Hina Sarwath, Gaurav Thareja, Annika Wahl, Robert Kirk DeLisle, Larry Gold, Marija Pezer, Gordan Lauc, Mohammed A El-Din Selim, Dennis O Mook-Kanamori, Eman K Al-Dous, Yasmin A Mohamoud, Joel Malek, Konstantin Strauch, Harald Grallert, Annette Peters, Gabi Kastenmüller, Christian Gieger, Johannes Graumann
No abstract text is available yet for this article.
April 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28382590/elevated-syndecan-1-levels-in-the-sera-of-patients-with-breast-cancer-correlate-with-tumor-size
#12
Zahra Malek-Hosseini, Sina Jelodar, Abdolrasoul Talei, Abbas Ghaderi, Mehrnoosh Doroudchi
BACKGROUND: Breast cancer is the leading type of cancer in Iranian women and affects them at least one decade younger than their counterparts in developed countries. Breast tumor progression and metastasis is accompanied by a decrease in the membranous expression of Syndecan-1 and an increase in its shedding. We measured the level of soluble Syndecan-1 in the sera of Iranian patients with breast cancer. METHODS: The study population included 61 chemotherapy-naïve breast cancer patients and 30 age/sex-matched healthy individuals...
April 5, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28374551/the-impact-of-hyperglycemia-on-adhesion-between-endothelial-and-cancer-cells-revealed-by-single-cell-force-spectroscopy
#13
Katarzyna E Malek-Zietek, Marta Targosz-Korecka, Marek Szymonski
The impact of hyperglycemia on adhesion between lung carcinoma cells (A549) and pulmonary human aorta endothelial cells (PHAEC) was studied using the single-cell force spectroscopy. Cancer cells were immobilized on a tipless Atomic Force Microscopy (AFM) cantilever and a single layer of endothelial cells was prepared on a glass slide. The measured force-distance curves provided information about the detachment force and about the frequency of specific ligand-receptor rupture events. Measurements were performed for different times of short term (up to 2 h) and prolonged hyperglycemia (3 h - 24 h)...
April 4, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28369962/biological-activities-of-undescribed-north-american-lichen-species
#14
Erik A Yeash, Lyndon Letwin, Lada Malek, Zacharias Suntres, Kerry Knudsen, Lew P Christopher
BACKGROUND: Lichens provide a large array of compounds with the potential for pharmaceutical development. In the present study, extracts from three previously undescribed North American lichen species were examined for antioxidant, antibacterial and anticancer activities. RESULTS: The results from this study demonstrated the following: 1) Acarospora socialis ethanol extract exhibited significant DPPH antioxidant scavenging activities which were concentration-dependent; 2) the acetone and ethyl acetate extracts of Xanthoparmelia mexicana inhibited Gram-positive bacteria but had no effect on Gram-negative bacteria; the X...
April 2, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28367747/hiv-risk-and-prevention-among-men-who-have-sex-with-men-in-rural-south-africa
#15
Kabelo Maleke, Nosipho Makhakhe, Remco Ph Peters, Geoffrey Jobson, Glenn De Swardt, Joseph Daniels, Timothy Lane, James A McIntyre, John Imrie, Helen Struthers
Rural South African men who have sex with men (MSM) are likely to be underserved in terms of access to relevant healthcare and HIV prevention services. While research in urban and peri-urban MSM populations has identified a range of factors affecting HIV risk in South African MSM, very little research is available that examines HIV risk and prevention in rural MSM populations. This exploratory study begins to address this lack by assessing perceptions of HIV risk among MSM in rural Limpopo province. Using thematic analysis of interview and discussion data, two overarching global themes that encapsulated participants' understandings of HIV risk and the HIV risk environment in their communities were developed...
March 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/28365005/neocortical-and-hippocampal-trem2-protein-levels-during-the-progression-of-alzheimer-s-disease
#16
Sylvia E Perez, Muhammad Nadeem, Bin He, Jennifer C Miguel, Michael H Malek-Ahmadi, Kewei Chen, Elliott J Mufson
Heterozygous triggering receptor expressed on myeloid cells (TREM2) mutations are an Alzheimer's disease (AD) risk factor. Nonmutated TREM2 dysregulation occurs in AD brain. Whether TREM2 is altered in prodromal AD remains unknown. Western blotting was used to determine levels of TREM2 (∼25 kDa) and Iba1 in the frontal cortex and TREM2 in the hippocampus from people who died with an ante-mortem clinical diagnosis of non- and mild-cognitive impairment, mild/moderate AD, and severe AD (sAD). Immunohistochemistry defined the relationship between amyloid and Iba1 profiles...
June 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28361279/outcomes-after-hand-and-upper-extremity-transplantation
#17
Jaimie T Shores, Veronika Malek, W P Andrew Lee, Gerald Brandacher
Hand and upper extremity transplantation (HUET) has emerged as the most frequently performed reconstructive procedure in the burgeoning field of vascularized composite allotransplantation (VCA). VCA refers to a form of transplant with multiple tissue types that represents a viable treatment option for devastating injuries where conventional reconstruction would be unable to restore form and function. As hand transplantation becomes increasingly more common, discussions on advantages and disadvantages of the procedure seem to intensify...
May 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28359604/extra-corporeal-photochemotherapy-in-steroid-refractory-graft-versus-host-disease-a-review-of-guidelines-and-recommendations
#18
REVIEW
Saeed Mohammadi, Ashraf Malek Mohammadi, Amir Hossein Norooznezhad, Farhad Heshmati, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
Regardless of remarkable progresses in prevention and treatment approaches, graft versus host disease (GVHD) remains a major impediment for successful allogeneic hematopoietic stem cells transplantation (HSCT) and leads to morbidity and mortality in transplanted patients. Corticosteroids are the standard therapy for GVHD; however, a great number of patients will not respond sufficiently and others will be significantly affected by adverse effects of steroids. Extracorporeal photochemotherapy (ECP), as one of the numerous second line therapies, through modulation of immune cells may improves GVHD affected organ function in steroid-refractory forms...
February 16, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28359488/left-atrial-and-carotid-body-paraganglioma
#19
Khaled Abdelhady, Samarth Durgam, Daniela Orza, Malek G Massad
We report a rare case of left atrial paraganglioma with a synchronous carotid body paraganglioma in a 30-year-old man with succinate dehydrogenase B gene mutation. The patient initially presented with a neck mass and palpitations. Laboratory test results showed elevated catecholamine levels. A cardiac paraganglioma was identified by computed tomography, meta-iodobenzylguanidine scintigraphy, and magnetic resonance imaging. Surgical resection of both paragangliomas were performed on two separate occasions. Serum and urine catecholamine levels returned to normal range...
April 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28352480/transcatheter-aortic-valve-implantation-in-an-extremely-tortuous-s-shaped-aorta
#20
Shuangbo Liu, Olga Toleva, Amir Ravandi, Zlatko Pozeg, Alan Menkis, Malek Kass
Transcatheter aortic valve implantation (TAVI) has emerged as an alternative technique to treating aortic stenosis in patients with high surgical risk. We present a case of a successful transfemoral TAVI in a high-risk patient with an extremely tortuous iliofemoral system and a significant S-type bend in the descending aorta. With careful preprocedure planning and using all the techniques available, TAVI can be performed in the most challenging patients.
2017: Case Reports in Cardiology
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