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https://www.readbyqxmd.com/read/29144395/real-time-indoor-scene-description-for-the-visually-impaired-using-autoencoder-fusion-strategies-with-visible-cameras
#1
Salim Malek, Farid Melgani, Mohamed Lamine Mekhalfi, Yakoub Bazi
This paper describes three coarse image description strategies, which are meant to promote a rough perception of surrounding objects for visually impaired individuals, with application to indoor spaces. The described algorithms operate on images (grabbed by the user, by means of a chest-mounted camera), and provide in output a list of objects that likely exist in his context across the indoor scene. In this regard, first, different colour, texture, and shape-based feature extractors are generated, followed by a feature learning step by means of AutoEncoder (AE) models...
November 16, 2017: Sensors
https://www.readbyqxmd.com/read/29142650/early-childhood-development-and-iranian-parents-knowledge-a-qualitative-study
#2
Elham Habibi, Firouzeh Sajedi, Hosein Malek Afzali, Nikta Hatamizadeh, Soheila Shahshahanipour, Frances Page Glascoe
Background: Early childhood is the most important step throughout the lifespan and it is a critical period continuing to the end of 8-year-old. Mothers' knowledge is one of the important aspects of child development. The goals of this study were to determine the situation of knowledge in Iranian parents about the concept and the importance of early childhood development (ECD) and determining the sources of parental knowledge about ECD from the perspective of parents and grandparents. Methods: This qualitative study was conducted based on the directional content analysis in 2016...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29142404/chalepin-a-compound-from-ruta-angustifolia-l-pers-exhibits-cell-cycle-arrest-at-s-phase-suppresses-nuclear-factor-kappa-b-nf-%C3%AE%C2%BAb-pathway-signal-transducer-and-activation-of-transcription-3-stat3-phosphorylation-and-extrinsic-apoptotic-pathway-in-non-small-cell
#3
Jaime Stella Moses Richardson, Norhaniza Aminudin, Sri Nurestri Abd Malek
Background: Plants have been a major source of inspiration in developing novel drug compounds in the treatment of various diseases that afflict human beings worldwide. Ruta angustifolia L. Pers known locally as Garuda has been conventionally used for various medicinal purposes such as in the treatment of cancer. Objective: A dihydrofuranocoumarin named chalepin, which was isolated from the chloroform extract of the plant, was tested on its ability to inhibit molecular pathways of human lung carcinoma (A549) cells...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141605/an-intronic-single-nucleotide-polymorphism-rs13217795-in-foxo3-is-associated-with-asthma-and-allergic-rhinitis-a-case-case-control-study
#4
Justin Z Amarin, Randa G Naffa, Haya H Suradi, Yousof M Alsaket, Nathir M Obeidat, Tareq M Mahafza, Malek A Zihlif
BACKGROUND: Asthma and allergic rhinitis are respiratory diseases with a significant global burden. Forkhead box O3 (FOXO3) is a gene involved in the etiology of a number of respiratory diseases. The objective of this study is to assess the association of rs13217795, an intronic FOXO3 single-nucleotide polymorphism, with asthma and allergic rhinitis. METHODS: In this case-case-control genetic association study, genotyping was conducted using the PCR-RFLP method...
November 15, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29138181/one-year-outcome-of-intensive-insulin-therapy-combined-to-glucose-insulin-potassium-in-acute-coronary-syndrome-a-randomized-controlled-study
#5
Wahid Bouida, Kaouthar Beltaief, Mohamed Amine Msolli, Nasri Bzeouich, Adel Sekma, Malek Echeikh, Malek Mzali, Hamdi Boubaker, Mohamed Habib Grissa, Riadh Boukef, Mohsen Hassine, Zohra Dridi, Asma Belguith, Fadhel Najjar, Ines Khochtali, Semir Nouira
BACKGROUND: A number of factors may offset the cardioprotective effects of glucose-insulin-potassium (GIK) on outcome of patients with acute coronary syndrome, such as hyperglycemia induced by this cocktail infusion. We performed a study to evaluate the effect of intensive insulin therapy in association with GIK on 1-year outcome in patients hospitalized for acute coronary syndrome. METHODS AND RESULTS: In a randomized prospective controlled trial we included 772 patients with non-ST-segment elevation acute coronary syndrome...
November 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29134405/cell-type-specific-gene-expression-patterns-in-the-knee-cartilage-in-an-osteoarthritis-rat-model
#6
Michal Korostynski, Natalia Malek, Marcin Piechota, Katarzyna Starowicz
Osteoarthritis (OA) is a chronic degenerative disease that leads to joint failure, pain, and disability. Gene regulation is implicated as a driver of the imbalance between the expression of catabolic and anabolic factors that eventually leads to the degeneration of osteoarthritic cartilage. In our model, knee-joint OA was induced in male Wistar rats by intra-articular sodium monoiodoacetate (MIA) injections. Whole-genome microarrays were used to analyse the alterations in gene expression during the time-course of OA development (at 2, 14, and 28 days post-injection) in rat knee joints...
November 13, 2017: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29120376/real-time-alpine-measurement-system-using-wireless-sensor-networks
#7
Sami A Malek, Francesco Avanzi, Keoma Brun-Laguna, Tessa Maurer, Carlos A Oroza, Peter C Hartsough, Thomas Watteyne, Steven D Glaser
Monitoring the snow pack is crucial for many stakeholders, whether for hydro-power optimization, water management or flood control. Traditional forecasting relies on regression methods, which often results in snow melt runoff predictions of low accuracy in non-average years. Existing ground-based real-time measurement systems do not cover enough physiographic variability and are mostly installed at low elevations. We present the hardware and software design of a state-of-the-art distributed Wireless Sensor Network (WSN)-based autonomous measurement system with real-time remote data transmission that gathers data of snow depth, air temperature, air relative humidity, soil moisture, soil temperature, and solar radiation in physiographically representative locations...
November 9, 2017: Sensors
https://www.readbyqxmd.com/read/29119281/-swarm-relaxation-equilibrating-a-large-ensemble-of-computer-simulations-%C3%A2
#8
Shahrazad M A Malek, Richard K Bowles, Ivan Saika-Voivod, Francesco Sciortino, Peter H Poole
It is common practice in molecular dynamics and Monte Carlo computer simulations to run multiple, separately-initialized simulations in order to improve the sampling of independent microstates. Here we examine the utility of an extreme case of this strategy, in which we run a large ensemble of M independent simulations (a "swarm"), each of which is relaxed to equilibrium. We show that if M is of order [Formula: see text], we can monitor the swarm's relaxation to equilibrium, and confirm its attainment, within [Formula: see text], where [Formula: see text] is the equilibrium relaxation time...
November 10, 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29118233/hairy-cell-leukemia-version-2-2018-nccn-clinical-practice-guidelines-in-oncology
#9
William G Wierda, John C Byrd, Jeremy S Abramson, Seema Bhat, Greg Bociek, Danielle Brander, Jennifer Brown, Asher Chanan-Khan, Steve E Coutre, Randall S Davis, Christopher D Fletcher, Brian Hill, Brad S Kahl, Manali Kamdar, Lawrence D Kaplan, Nadia Khan, Thomas J Kipps, Jeffrey Lancet, Shuo Ma, Sami Malek, Claudio Mosse, Mazyar Shadman, Tanya Siddiqi, Deborah Stephens, Nina Wagner, Andrew D Zelenetz, Mary A Dwyer, Hema Sundar
Hairy cell leukemia (HCL) is a rare type of indolent B-cell leukemia, characterized by symptoms of fatigue and weakness, organomegaly, pancytopenia, and recurrent opportunistic infections. Classic HCL should be considered a distinct clinical entity separate from HCLvariant (HCLv), which is associated with a more aggressive disease course and may not respond to standard HCL therapies. Somatic hypermutation in the IGHV gene is present in most patients with HCL. The BRAF V600E mutation has been reported in most patients with classic HCL but not in those with other B-cell leukemias or lymphomas...
November 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29113678/a-large-single-institution-review-of-tracheoesophageal-fistulae-with-evaluation-of-the-use-of-transanastomotic-feeding-tubes
#10
Joseph C Fusco, Juan L Calisto, Barbara A Gaines, Marcus M Malek
INTRODUCTION: Transanastomatic feeding tube (TAT) use in the repair of tracheoesophageal fistulas (TEF) with or without esophageal atresia (EA) and EA with or without TEF allows for earlier enteral feedings, however, may predispose to esophageal stricture. METHODS: We review our institutional experience with esophageal atresia repair over a 15-year period from 2000 to 2015 and report on our observed complication rate with emphasis on the surgical approach and use of TATs...
October 10, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29113001/the-impact-of-high-end-ultrasound-in-the-management-of-a-patient-with-neuroendocrine-tumor-of-the-ileum
#11
Tatjana Schmidt, Julia M Schwarz, Martina Steurer, Martin Goetz, Susann-Cathrin Olthof, Nisar P Malek, Bita Boozari
Diagnostic imaging of jejuno-ileal neuroendocrine tumors (NETs) has been described as challenging. Follow-up requires the detection of metastatic spread as well as screening for local recurrence. Multimodal imaging concepts must often be applied.We report the case of a 45-year-old man with a history of ileal NET. At 2 points in follow-up of our patient, information provided by high-end ultrasound changed prognosis and treatment considerably: when positron emission tomography/computed tomography newly detected suspected hepatic metastases, contrast-enhanced ultrasound correctly identified the lesions as intrahepatic vascular shunts...
November 7, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29111498/transcriptomic-response-of-debaryomyces-hansenii-during-mixed-culture-in-a-liquid-model-cheese-medium-with-yarrowia-lipolytica
#12
Reine Malek, Pascal Bonnarme, Françoise Irlinger, Pascale Frey-Klett, Djamila Onésime, Julie Aubert, Valentin Loux, Jean-Marie Beckerich
Yeasts play a crucial role in cheese ripening. They contribute to the curd deacidification, the establishment of acid-sensitive bacterial communities, and flavour compounds production via proteolysis and catabolism of amino acids (AA). Negative yeast-yeast interaction was observed between the yeast Yarrowia lipolytica 1E07 (YL1E07) and the yeast Debaryomyces hansenii 1L25 (DH1L25) in a model cheese but need elucidation. YL1E07 and DH1L25 were cultivated in mono and co-cultures in a liquid synthetic medium (SM) mimicking the cheese environment and the growth inhibition of DH1L25 in the presence of YL1E07 was reproduced...
October 24, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29107725/proximal-stenosis-is-associated-with-rupture-status-in-middle-cerebral-artery-aneurysms
#13
Alexei Antonov, Kenichi Kono, Kilian Greim-Kuczewski, James E Hippelheuser, Alexandra Lauric, Adel M Malek
BACKGROUND: Hemodynamic factors impact cerebral aneurysm development and progression. Parent vessel architectural features, such as caliber, curvature and angle can affect downstream pressure and shear stress. OBJECTIVE: Investigate the association between proximal parent vessel stenosis and aneurysm rupture status at the middle cerebral artery (MCA) bifurcation. METHODS: Catheter 3D rotational angiographic datasets from 69 Japanese patients with MCA aneurysms (58 unruptured/11 ruptured) were analyzed...
October 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29106918/use-of-intraoperative-nuclear-imaging-leads-to-decreased-anesthesia-time-and-real-time-confirmation-of-lesion-removal
#14
Joseph C Fusco, Brittani K N Seynnaeve, Alexander J Davit, Michael R Czachowski, Judith M Joyce, Barbara A Gaines, Marcus M Malek
BACKGROUND: Lymphatic mapping to guide sentinel lymph node biopsy (SLNB) typically requires lymphoscintigraphy prior to surgery. In young pediatric patients, this process often requires intubation in the nuclear medicine suite followed by transport to the operating room (OR). METHODS: We reviewed 14 pediatric cases in which a portable nuclear imaging camera was utilized to perform the entirety of the SLNB in the OR. RESULTS AND CONCLUSION: This method, utilizing intraoperative nuclear imaging, helped to confirm removal of the sentinel lymph node in real time, decreased anesthesia time, and avoided transport of a sedated or intubated child...
October 9, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29102254/a-systematic-review-and-meta-analysis-on-the-oncological-long-term-outcomes-after-trimodality-therapy-and-radical-cystectomy-with-or-without-neoadjuvant-chemotherapy-for-muscle-invasive-bladder-cancer
#15
REVIEW
Omar Fahmy, Mohd Ghani Khairul-Asri, Tina Schubert, Markus Renninger, Rohan Malek, Hubert Kübler, Arnulf Stenzl, Georgios Gakis
OBJECTIVE: This study aimed to comprehensively analyze the oncological long-term outcomes of trimodal therapy (TMT) and radical cystectomy (RC) for the treatment of muscle-invasive bladder cancer (BC) with or without neoadjuvant chemotherapy (NAC). PATIENTS AND METHODS: A systematic search was conducted according to the PRISMA guidelines for studies reporting on outcomes after TMT and RC. A total of 57 studies including 30,293 patients were included. The 10-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates for TMT and RC were assessed...
October 25, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29101826/ligand-based-computational-modelling-of-platelet-derived-growth-factor-beta-receptor-leading-to-new-angiogenesis-inhibitory-leads
#16
Rua'a A Al-Aqtash, Malek A Zihlif, Hana Hammad, Zeyad D Nassar, Jehad Al Meliti, Mutasem O Taha
Platelet derived growth factor beta receptor (PDGFR- β) plays an important role in angiogenesis. PDGFR-β expression is correlated with increased vascularity and maturation of blood vessels in cancer. Pharmacophore modeling and quantitative structure-activity relationship (QSAR) analysis were combined to explore the structural requirements for ligand-PDGFR-β recognition using 107 known PDGFR-β inhibitors. Genetic function algorithm (GFA) coupled to k nearest neighbor (kNN) and multiple linear regression (MLR) analysis were employed to generate predictive QSAR models based on optimal combinations of pharmacophores and physicochemical descriptors...
October 10, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29101696/effect-of-long-term-exposure-to-ambient-particulate-matter-on-prevalence-of-type-2-diabetes-and-hypertension-in-iranian-adults-an-ecologic-study
#17
Mohammad Sadegh Hassanvand, Kazem Naddafi, Mojtaba Malek, Ameneh Ebrahim Valojerdi, Mohanad Mirzadeh, Tahereh Samavat, Alireza Mahdavi Hezaveh, Alieh Hodjatzadeh, Mohammad Ebrahim Khamseh
Air pollution is considered as an environmental risk to health worldwide. Current evidence is mostly from Western populations exposed to lower levels of pollutants. This study was to explore the association of type 2 diabetes (T2D) and hypertension prevalence with exposure to high levels of air pollution in Iranian adults. The air pollution data were obtained from the air quality monitoring stations of five large cities in Iran from 2006 to 2011. The air quality monitoring stations could only detect ambient particulate matter_10 (PM10) during the study period; therefore, the average PM10 concentration was considered for comparison...
November 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29101003/fatal-accelerated-rejection-with-a-prominent-natural-killer-cell-infiltrate-in-a-heart-transplant-recipient-with-peripartum-cardiomyopathy
#18
Ali Javaheri, Amber R Wang, Eline Luning Prak, Priti Lal, Lee R Goldberg, Malek Kamoun
Accelerated rejection is uncommon after cardiac transplantation. The mechanism is hypothesized to be mediated by cytotoxic T cells and anti-HLA antibodies resulting from a memory response to the donor allograft in sensitized patients. A role for Natural Killer (NK) cell in cellular rejection has also been suggested. We report a case of fulminant accelerated rejection in a heart transplant recipient, with a history of peripartum cardiomyopathy (PPMC). The patient had no pre-transplant donor specific antibody and flow cytometric T and B cell crossmatches were negative...
October 31, 2017: Transplant Immunology
https://www.readbyqxmd.com/read/29100049/pip-ing-lipids-on-membranes-pten-takes-the-cake
#19
Archna Ravi, Brooke M Emerling
In this issue of Molecular Cell, Malek et al. (2017) describe a novel HPLC-MS method permitting separation of PI(3,4)P2 and PI(4,5)P2, a technical issue hindering the phosphoinositide signaling field. They use this method to uncover a new target and critical role for PTEN in cancer.
November 2, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29097947/evaluation-of-static-and-dynamic-balance-tests-in-single-and-dual-task-conditions-in-participants-with-nonspecific-chronic-low-back-pain
#20
Ladan Hemmati, Zahra Rojhani-Shirazi, Hamid Malek-Hoseini, Ismail Mobaraki
Objective: The purpose of this study was to investigate static and dynamic balance tests in single, dual cognitive, and dual manual task conditions in participants with and without nonspecific chronic low back pain. Methods: In this case control study, 40 patients (age range 18-50 years) with nonspecific chronic low back pain for at least 3 months and 40 healthy participants matched for age, weight, height, and sex participated in this study. Balance performance was evaluated using static (One Leg Stance) and dynamic (Modified Star Excursion Balance Test, 10-m walk test, and Timed Up and Go) balance tests...
September 2017: Journal of Chiropractic Medicine
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