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https://www.readbyqxmd.com/read/28089924/water-juice-or-soda-mothers-and-grandmothers-of-preschoolers-discuss-the-acceptability-and-accessibility-of-beverages
#1
Karin Eli, Agneta Hörnell, Mahnoush Etminan Malek, Paulina Nowicka
Intake of sugary beverages is strongly associated with weight gain and obesity among children; however, differences between mothers' and grandmothers' attitudes and practices concerning young children's beverage consumption remain unclear. This is notable since about a quarter of families in the US and the UK rely on grandparents as the main providers of informal childcare. The aim of this study is to examine mothers' and maternal grandmothers' attitudes, knowledge, and practices regarding preschool-age children's beverage consumption...
January 12, 2017: Appetite
https://www.readbyqxmd.com/read/28068695/laparoscopically-guided-percutaneous-choledochoscopy-minimally-invasive-interdisciplinary-rendezvous-for-selected-patients
#2
Marty Zdichavsky, Bernhard Hirt, Andreas Kramer, Alfred Königsrainer, Nisar P Malek, Ulrich Schweizer, Martin Goetz
No abstract text is available yet for this article.
February 2017: Endoscopy
https://www.readbyqxmd.com/read/28060738/the-prognostic-value-of-clonal-heterogeneity-and-quantitative-assessment-of-plasma-circulating-clonal-ig-vdj-sequences-at-diagnosis-in-patients-with-follicular-lymphoma
#3
Clémentine Sarkozy, Sarah Huet, Victoria E H Carlton, Bettina Fabiani, Alain Delmer, Fabrice Jardin, Marie-Helene Delfau-Larue, Maya Hacini, Vincent Ribrag, Stéphanie Guidez, Malek Faham, Gilles Salles
Recent advances in next-generation sequencing (NGS) have enabled the quantitation of circulating tumour DNA (ctDNA) encoding the clonal rearranged V(D)J immunoglobulin locus. We aimed to evaluate the clonal heterogeneity of follicular lymphoma (FL) in the tumour and the plasma at diagnosis and to assess the prognostic value of the ctDNA level. Plasma samples at diagnosis were available for 34 patients registered in the PRIMA trial (NCT00140582). One tumour clonotype or more could be detected for 29 (85%) and 25 (74%) patients, respectively, in the tumour or plasma samples...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28054667/yersinia-pestis-halotolerance-illuminates-plague-reservoirs
#4
Maliya Alia Malek, Idir Bitam, Anthony Levasseur, Jérôme Terras, Jean Gaudart, Said Azza, Christophe Flaudrops, Catherine Robert, Didier Raoult, Michel Drancourt
The plague agent Yersinia pestis persists for years in the soil. Two millennia after swiping over Europe and North Africa, plague established permanent foci in North Africa but not in neighboring Europe. Mapping human plague foci reported in North Africa for 70 years indicated a significant location at <3 kilometers from the Mediterranean seashore or the edge of salted lakes named chotts. In Algeria, culturing 352 environmental specimens naturally containing 0.5 to 70 g/L NaCl yielded one Y. pestis Orientalis biotype isolate in a 40 g/L NaCl chott soil specimen...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28053183/the-transcription-factor-gata4-promotes-myocardial-regeneration-in-neonatal-mice
#5
Mona Malek Mohammadi, Badder Kattih, Andrea Grund, Natali Froese, Mortimer Korf-Klingebiel, Anna Gigina, Ulrike Schrameck, Carsten Rudat, Qiangrong Liang, Andreas Kispert, Kai C Wollert, Johann Bauersachs, Joerg Heineke
Heart failure is often the consequence of insufficient cardiac regeneration. Neonatal mice retain a certain capability of myocardial regeneration until postnatal day (P)7, although the underlying transcriptional mechanisms remain largely unknown. We demonstrate here that cardiac abundance of the transcription factor GATA4 was high at P1, but became strongly reduced at P7 in parallel with loss of regenerative capacity. Reconstitution of cardiac GATA4 levels by adenoviral gene transfer markedly improved cardiac regeneration after cryoinjury at P7...
January 4, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28051234/neonatal-lupus-erythematosus-with-congenital-heart-block-in-twins
#6
Lamia Gargouri, Faiza Safi, Bayen Maalej, Souad Mallek, Fatma Turki, Imen Majdoub, Malek Akrout, Dorra Abid, Samir Kamoun, Abdelmajid Mahfoudh
Background - Neonatal lupus erythematosus is an uncommon acquired autoimmune disease caused by transplacental passage of maternal antibodies SSA/Ro, SSB/La or U1 ribonucleoproteins. The most common clinical manifestations are skin rash, cardiac lesions, thrombocytopenia, anemia and hepatosplenomegaly. Complete congenital heart block is usually irreversible needing a pacemaker implantation in two-thirds of cases. Cases report - We report neonatal lupus erythematosus with complete congenital heart block in twins...
July 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28045975/titin-truncating-variants-in-dilated-cardiomyopathy-prevalence-and-genotype-phenotype-correlations
#7
Maria Franaszczyk, Przemyslaw Chmielewski, Grazyna Truszkowska, Piotr Stawinski, Ewa Michalak, Malgorzata Rydzanicz, Malgorzata Sobieszczanska-Malek, Agnieszka Pollak, Justyna Szczygieł, Joanna Kosinska, Adam Parulski, Tomasz Stoklosa, Agnieszka Tarnowska, Marcin M Machnicki, Bogna Foss-Nieradko, Malgorzata Szperl, Agnieszka Sioma, Mariusz Kusmierczyk, Jacek Grzybowski, Tomasz Zielinski, Rafal Ploski, Zofia T Bilinska
TTN gene truncating variants are common in dilated cardiomyopathy (DCM), although data on their clinical significance is still limited. We sought to examine the frequency of truncating variants in TTN in patients with DCM, including familial DCM (FDCM), and to look for genotype-phenotype correlations. Clinical cardiovascular data, family histories and blood samples were collected from 72 DCM probands, mean age of 34 years, 45.8% FDCM. DNA samples were examined by next generation sequencing (NGS) with a focus on the TTN gene...
2017: PloS One
https://www.readbyqxmd.com/read/28039913/the-unfolded-protein-response-mediates-fibrogenesis-and-collagen-i-secretion-through-regulating-tango1-in-mice
#8
Jessica L Maiers, Enis Kostallari, Malek Mushref, Thiago M deAssuncao, Haiyang Li, Nidhi Jalan-Sakrikar, Robert C Huebert, Sheng Cao, Harmeet Malhi, Vijay H Shah
: Fibrogenesis encompasses the deposition of matrix proteins, such as collagen I, by hepatic stellate cells (HSCs) that culminates in cirrhosis. Fibrogenic signals drive transcription of procollagen I, which enters the endoplasmic reticulum (ER), is trafficked through the secretory pathway, and released to generate extracellular matrix. Alternatively, disruption of procollagen I ER export could activate the unfolded protein response (UPR) and drive HSC apoptosis. Using a small interfering RNA screen, we identified Transport and Golgi organization 1 (TANGO1) as a potential participant in collagen I secretion...
November 5, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28035022/approach-for-classification-and-severity-grading-of-long-term-and-late-onset-health-events-among-childhood-cancer-survivors-in-the-st-jude-lifetime-cohort
#9
Melissa M Hudson, Matthew J Ehrhardt, Nickhill Bhakta, Malek Baassiri, Hesham Eissa, Wassim Chemaitilly, Daniel M Green, Daniel A Mulrooney, Gregory T Armstrong, Tara M Brinkman, James L Klosky, Kevin R Krull, Noah D Sabin, Carmen L Wilson, I-Chan Huang, Johnnie K Bass, Karen Hale, Sue Kaste, Raja B Khan, Deo Kumar Srivastava, Yutaka Yasui, Vijaya M Joshi, Saumini Srinivasan, Dennis Stokes, Mary Ellen Hoehn, Matthew Wilson, Kirsten K Ness, Leslie L Robison
Characterization of toxicity associated with cancer and its treatment is essential to quantify risk, inform optimization of therapeutic approaches for newly diagnosed patients, and guide health surveillance recommendations for long-term survivors. The National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE) provides a common rubric for grading severity of adverse outcomes in cancer patients that is widely used in clinical trials. The CTCAE has also been used to assess late cancer treatment-related morbidity, but is not fully representative of the spectrum of events experienced by pediatric and aging adult survivors of childhood cancer...
December 29, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28031229/t-cell-repertoire-diversification-is-associated-with-immune-related-toxicities-following-ctla-4-blockade-in-cancer-patients
#10
Lawrence Fong, David Y Oh, Jason Cham, Li Zhang, Grant Fong, Serena S Kwek, Mark Klinger, Malek Faham
Immune checkpoint inhibitors can induce clinical responses with many cancers but also immune-related adverse events (IRAEs). Mechanisms driving IRAEs are unknown. Because CTLA-4 blockade leads to proliferation of circulating T cells, we examined whether ipilimumab leads to clonal expansion of tissue-reactive T cells. Rather than narrowing the T cell repertoire to a limited number of clones, ipilimumab induced greater repertoire diversification in IRAE patients compared to patients without IRAEs, with increases in the numbers of clonotypes, including newly detected clones, and declines in T cell clonality overall...
December 28, 2016: Cancer Research
https://www.readbyqxmd.com/read/28006929/sedative-effects-of-intranasal-oxytocin-in-rabbits-and-rhesus-monkeys
#11
L Hess, M Votava, J Málek, A Kurzová, J Slíva
Oxytocin is a hormone therapeutically used mainly for its peripheral effects during pregnancy in the uterus and breasts. However, additional central effects, i.e. anxiolytic effect, decreased level of social stress and increased empathy have been also observed. Hence, the aim of our study was to evaluate if nasal oxytocin can be used as anxiolytic substance in rhesus monkeys (n=20) and rabbits (n=20). Simultaneously, mean arterial blood pressure, arterial oxygen saturation of hemoglobin and pulse rate were monitored in all the evaluated animals...
December 21, 2016: Physiological Research
https://www.readbyqxmd.com/read/28002888/discovery-of-t-cell-receptor-beta-motifs-specific-to-hla-b27-ankylosing-spondylitis-by-deep-repertoire-sequence-analysis
#12
Malek Faham, Victoria Carlton, Martin Moorhead, Jianbiao Zheng, Mark Klinger, Francois Pepin, Thomas Asbury, Marissa Vignali, Ryan O Emerson, Harlan S Robins, James Ireland, Emily Baechler-Gillespie, Robert D Inman
OBJECTIVE: Ankylosing spondylitis (AS), a chronic inflammatory disorder, has a striking association with HLA-B27. One hypothesis suggests that a common antigen that binds to HLA-B27 is important for AS disease pathogenesis. We utilized T-cell repertoire next-generation sequencing to determine sequences and motifs that are shared among HLA-B27 positive (B27(+) ) AS patients. METHODS: To identify motifs enriched among B27(+) AS patients, we performed T-cell receptor beta (TCRβ) repertoire sequencing from 191 B27(+) AS patients, 43 B27(neg) AS patients and 227 controls, and we obtained >77 million TCRβ clonotype sequences...
December 21, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28001140/cultivating-administrative-support-for-a-clinical-ethics-consultation-service
#13
Courtney R Bruce, Mary A Majumder, Ashley Stephens, Janet Malek, Amy McGuire
Hospital administrators may lack familiarity with what clinical ethicists do (and do not do), and many clinical ethicists report receiving inadequate financial support for their clinical ethics consultation services (CECSs). Ethics consultation is distinct in that it is not reimbursable by third parties, and its financial benefit to the hospital may not be quantifiable. These peculiarities make it difficult for clinical ethicists to resort to tried-and-true outcome-centered evaluative strategies, like cost reduction or shortened length of stay for patients, to show a "need" for ethics consultation...
2016: Journal of Clinical Ethics
https://www.readbyqxmd.com/read/27992063/rb-but-not-r-hcvad-is-a-feasible-induction-regimen-prior-to-auto-hct-in-frontline-mcl-results-of-swog-study-s1106
#14
Robert W Chen, Hongli Li, Steven H Bernstein, Samir Kahwash, Lisa M Rimsza, Stephen J Forman, Louis Constine, Thomas C Shea, Amanda F Cashen, Kristie A Blum, Timothy S Fenske, Paul M Barr, Tycel Phillips, Michael Leblanc, Richard I Fisher, Bruce D Cheson, Sonali M Smith, Malek Faham, Jennifer Wilkins, John P Leonard, Brad S Kahl, Jonathan W Friedberg
Aggressive induction chemotherapy followed by autologous haematopoietic stem cell transplant (auto-HCT) is effective for younger patients with mantle cell lymphoma (MCL). However, the optimal induction regimen is widely debated. The Southwestern Oncology Group S1106 trial was designed to assess rituximab plus hyperCVAD/MTX/ARAC (hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone, alternating with high dose cytarabine and methotrexate) (RH) versus rituximab plus bendamustine (RB) in a randomized phase II trial to select a pre-transplant induction regimen for future development...
December 19, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27984918/phone-based-safety-monitoring-of-the-first-year-of-baclofen-treatment-for-alcohol-use-disorder-the-baclophone-cohort-study-protocol
#15
Benjamin Rolland, Marine Auffret, Julien Labreuche, Maryse Lapeyre-Mestre, Malek Dib, Aomar Kemkem, Isabelle Grit, Marie Drelon, Alain Duhamel, Nicolas Cabe, François Vabret, Olivier Guillin, Alexandre Baguet, Céline Masquelier, Alain Dervaux, Sylvie Deheul, Régis Bordet, Louise Carton, Olivier Cottencin, Renaud Jardri, Sophie Gautier
BACKGROUND: In France, baclofen is frequently used off-label for alcohol use disorder (AUD). Baclofen has been associated with diverse adverse events (AEs), but the causality of these AEs has never been properly assessed. METHODS/DESIGN: BACLOPHONE is a prospective multicenter cohort study conducted in the Hauts-de-France and Normandie French regions. BACLOPHONE consists of the phone-based monitoring of 792 patients during their first year of baclofen treatment for AUD...
December 21, 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27982677/pathophysiological-mechanisms-of-calcineurin-inhibitor-induced-nephrotoxicity-and-arterial-hypertension
#16
L Hošková, I Málek, L Kopkan, J Kautzner
Solid organ transplantation is an established treatment modality in patients with end-stage organ damage in cases where other therapeutic options fail. The long-term outcomes of solid organ transplant recipients have improved considerably since the introduction of the first calcineurin inhibitor (CNI) - cyclosporine. In 1984, the potent immunosuppressive properties of another CNI, tacrolimus, were discovered. The immunosuppressive effects of CNIs result from the inhibition of interleukin-2 synthesis and reduced proliferation of T-cells due to calcineurin blockade...
December 16, 2016: Physiological Research
https://www.readbyqxmd.com/read/27981400/strategies-and-challenges-in-recruiting-black-immigrant-mothers-for-a-community-based-study-on-child-nutritional-health-in-ottawa-canada
#17
Rosanne Blanchet, Dia Sanou, Constance P Nana, Elise Pauzé, Malek Batal, Isabelle Giroux
There is a need to identify barriers to participation as well as recruitment strategies to engage minority parents of young children in health-oriented research. This paper offers insights on strategies and challenges in recruiting black immigrant mothers living in Ottawa (Canada) for a community-based health-oriented research project among 6-to-12-year-old children. We recruited 259 mother-child dyads. Most participants were recruited by team members during community events, fairs, religious gatherings, etc...
December 15, 2016: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/27970047/tct-670-optimal-transcatheter-heart-valve-sizing-in-aortic-valve-in-valve-implantation-insights-from-the-valve-in-valve-international-data-vivid-%C3%A2-registry
#18
Sami Alnasser, Asim Cheema, Eric Horlick, Nicolas Van Mieghem, Gudrun Feuchtner, Matheus Simonato Dos Santos, Tanja Rudolph, Stephen Brecker, Pedro Lemos, Nicolo Piazza, Anibal Damonte, Malek Kass, Gábor Veress, Julinda Mehilli, Raffi Bekeredjian, James McCabe, Axel Linke, Felix Woitek, Lars Sondergaard, Nikolaos Bonaros, Ole De Backer, Stephan Ensminger, Hardy Baumbach, Jochen Wöhrle, Joachim Schofer, Marc Pelletier, John Webb, Danny Dvir
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27967218/protein-s-bacillithiolation-functions-in-thiol-protection-and-redox-regulation-of-the-glyceraldehyde-3-phosphate-dehydrogenase-gap-in-staphylococcus-aureus-under-hypochlorite-stress
#19
Marcel Imber, Nguyen Thi Thu Huyen, Agnieszka J Pietrzyk-Brzezinska, Vu Van Loi, Melanie Hillion, Jörg Bernhardt, Lena Thärichen, Katra Kolšek, Malek Saleh, Christopher J Hamilton, Lorenz Adrian, Frauke Gräter, Markus Wahl, Haike Antelmann
AIMS: Bacillithiol (BSH) is the major low molecular weight thiol of the human pathogen Staphylococcus aureus. Here, we used OxICAT and Voronoi redox treemaps to quantify hypochlorite-sensitive protein thiols in S. aureus USA300 and analyzed the role of BSH in protein S-bacillithiolation. RESULTS: The OxICAT analyses enabled the quantification of 228 Cys residues in the redox proteome of S. aureus USA300. Hypochlorite stress resulted in a >10% increased oxidation of 58 Cys residues (25...
December 14, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27939269/biological-properties-of-hertia-cheirifolia-l-flower-extracts-and-effect-of-the-nopol-on-%C3%AE-glucosidase
#20
Kaouther Majouli, Mohamed Ali Mahjoub, Fazal Rahim, Assia Hamdi, Abdul Wadood, Malek Besbes Hlila, Abderraouf Kenani
In screening for antioxidant and α-glucosidase inhibitors from the extracts of Hertia cheirifolia L. flowers, the petroleum ether extract showed interesting antioxidant activity and inhibitory effect on the activity of α-glucosidase. The fractionation of this extract resulted in the isolation of a compound which is characterized by NMR and ESI-MS as a nopol. The nopol exhibited potent α-glucosidase inhibitory potential with IC50 value of 220μM. The kinetic evaluation indicated that it acts as a non-competitive inhibitor...
February 2017: International Journal of Biological Macromolecules
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