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https://www.readbyqxmd.com/read/29913430/characteristics-and-outcomes-of-laparoscopic-surgery-in-patients-with-large-hiatal-hernia-a-single-center-study
#1
Angela Romano, Davide D'Amore, Giuseppe Esposito, Marianna Petrillo, Modestino Pezzella, Francesco Maria Romano, Giuseppe Izzo, Angelo Cosenza, Francesco Torelli, Antonio Volpicelli, Natale Di Martino
INTRODUCTION: Giant hiatal hernia is characterized by the presence of more than 1/3 of the stomach in the chest, through the diaphragmatic hiatus, with or without other intra-abdominal organs. It is a rare pathology, representing the 5-10% of all hiatal hernias. The advent of laparoscopic surgery led to new surgical techniques, which include the simple reduction with the excision of the hernial sac and the execution of a posterior hiatoplasty, with or without mesh, and the execution of a Collis-Nissen gatroplasty in case of short esophagus...
May 7, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29912361/evaluation-of-a-novel-infra-red-endoscopy-system-in-the-assessment-of-early-neoplasia-in-barretts-esophagus-pilot-study-from-a-single-center
#2
J Ortiz-Fernandez-Sordo, S S Sami, R Mansilla-Vivar, V Subramanian, J Mannath, E Telakis, K Ragunath
No abstract text is available yet for this article.
April 1, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29909900/mat%C3%A3-consumption-association-with-upper-aerodigestive-tract-cancers-a-systematic-review-and-meta-analysis
#3
REVIEW
Fernanda Weber Mello, Fernanda Marcello Scotti, Gilberto Melo, Saman Warnakulasuriya, Eliete Neves Silva Guerra, Elena Riet Correa Rivero
Maté is a beverage regularly consumed by Latin American populations. Upper aerodigestive tract (UADT) cancers are frequent in this region and are suspected to be associated with maté consumption. The aim of this systematic review and meta-analysis was to answer a focused question: "Is there an association between maté consumption and occurrence of the UADT cancer?". Studies investigating any association between maté consumption and occurrence of UADT cancer were included. Out of the 569 studies, 18 met the inclusion criteria for qualitative and 15 for quantitative analysis...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909416/non-invasive-detection-of-anastomotic-leakage-following-esophageal-and-pancreatic-surgery-by-urinary-analysis
#4
Victor D Plat, Nora van Gaal, James A Covington, Matthew Neal, Tim G J de Meij, Donald L van der Peet, Babs Zonderhuis, Geert Kazemier, Nanne K H de Boer, Freek Daams
BACKGROUND: Esophagectomy or pancreaticoduodenectomy is the standard surgical approach for patients with tumors of the esophagus or pancreatic head. Postoperative mortality is strongly correlated with the occurrence of anastomotic leakage (AL). Delay in diagnosis leads to delay in treatment, which ratifies the need for development of novel and accurate non-invasive diagnostic tests for detection of AL. Urinary volatile organic compounds (VOCs) reflect the metabolic status of an individual, which is associated with a systemic immunological response...
June 15, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29908982/intracardiac-tumors-with-extracardiac-extension-diagnosed-by-eus-fna-via-ebus
#5
Terunaga Inage, Takahiro Nakajima, Yuki Sata, Taiki Fujiwara, Syunichiro Iwasawa, Yuichi Takiguchi, Yukio Nakatani, Ichiro Yoshino
Obtaining biopsies for pathological diagnosis of primary cardiac tumors is challenging due to their anatomical location and the risk of tumor embolization. Due to the difficulty of histological diagnosis and limited treatment strategies, it is not uncommon to treat patients based on radiological findings alone. However, firm pathological diagnosis may permit more appropriate treatment selection, especially for those with primary cardiac lymphoma. EUS-B-FNA is a minimally invasive modality for sampling mediastinal lymph nodes and mediastinal lesions adjacent to the esophagus...
June 14, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29908962/targeting-orai1-mediated-store-operated-calcium-entry-by-rp4010-for-anti-tumor-activity-in-esophagus-squamous-cell-carcinoma
#6
Chaochu Cui, Yan Chang, Xiaoli Zhang, Sangyong Choi, Henry Tran, Kumar V Penmetsa, Srikant Viswanadha, Liwu Fu, Zui Pan
Esophageal cancer (EC) is the 6 t h leading cause of cancer mortality worldwide with poor prognosis, hence more effective chemotherapeutic drugs for this deadly disease are urgently needed. We previously reported that high expression of Orai1, a store-operated Ca2+ entry (SOCE) channel was associated with poor survival rate in EC patients and Orai1-mediated intracellular Ca2+ oscillations regulated cancer cell proliferation. Previous studies suggested that Orai1-mediated SOCE is a promising target for EC chemotherapy...
June 14, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29906417/selection-and-application-of-tissue-micrornas-for-non-endoscopic-diagnosis-of-barrett-s-esophagus
#7
Xiaodun Li, Sam Kleeman, Sally B Coburn, Carlo Fumagalli, Juliane Perner, Sriganesh Jammula, Ruth M Pfeiffer, Linda Orzolek, Haiping Hao, Philip R Taylor, Ahmad Miremadi, Núria Galeano-Dalmau, Pierre Lao-Sirieix, Maria Tennyson, Shona MacRae, Michael B Cook, Rebecca C Fitzgerald
BACKGROUND & AIMS: MicroRNA (miRNA) is highly stable in biospecimens and provides tissue-specific profiles, making it a useful biomarker of carcinogenesis. We aimed to discover a set of miRNAs that could accurately discriminate Barrett's esophagus (BE) from normal esophageal tissue and to test its diagnostic accuracy when applied to samples collected by a non-invasive esophageal cell sampling device. METHODS: We analyzed miRNA expression profiles of 2 independent sets of esophageal biopsy tissues collected during endoscopy from 38 patients with BE and 26 patients with normal esophagus (controls) using Agilent microarray and Nanostring counter assays...
June 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29905908/natural-history-of-barrett-s-esophagus
#8
REVIEW
Ernst J Kuipers, Manon C Spaander
Barrett's esophagus (BE) is a very common condition. We have obtained fairly profound knowledge of the natural history of this condition. This results from many cross-sectional and cohort studies, many describing patients undergoing long-term surveillance. Their consent to use their clinical data has improved our knowledge to the benefit of these same and other patients. The prevalence of BE increases with age both in men and in women. This increase starts at a younger age in men than in women. The incidence of high-grade dysplasia and cancer in BE depends on segment length, gender, and age...
June 15, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29905893/s093-pneumatic-balloon-dilation-for-palliation-of-recurrent-symptoms-of-achalasia-after-esophagomyotomy
#9
Riley D Stewart, Jeffrey Hawel, Daniel French, Drew Bethune, James Ellsmere
BACKGROUND: Achalasia is a chronic disease affecting the myenteric plexus of the esophagus and lower esophageal sphincter. Treatment is aimed at palliating symptoms to improve quality of life. Treatment options for symptom relapse after esophagomyotomy include botox injection, repeat myotomy, per-oral endoscopic myotomy, or pneumatic balloon dilation (PBD). Data demonstrating the safety and efficacy of PBD for recurrence are scarce. With a lack of published data, guidelines have suggested avoiding PBD for recurrent achalasia because of concern for a high risk of perforation...
June 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29905880/-black-esophagus-and-gastric-volvulus-following-slipped-laparoscopic-adjustable-gastric-band
#10
REVIEW
Carolyn Moore, Leslie Ray Matthews, Omar Danner, Assad Taha, Aviva Bashan-Gilzenrat, Jonathan Nguyen, Ed Childs, Kahdi Udobi
To review the entity "black esophagus" and sequela of a slipped laparoscopic adjustable band. The patient's history, physical examination, imaging, and endoscopic findings were reviewed. Detailed review of pathophysiology, presentation, diagnosis, management, and natural history was conducted. "Black esophagus," also known as acute esophageal necrosis (AEN), is a rare condition resulting in black discoloration of the mid to distal esophagus with less than a hundred reported cases. It has not been previously documented in bariatric surgery or following laparoscopic adjustable gastric banding...
June 15, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29905537/surgical-treatment-of-bening-esophageal-strictures-after-corrosive-injuries
#11
V Boyko, S Savvi, A Korolevska, V Zhydetskyy, Y Novikov, S Bytiak, D Shuba
The research is based on the results of the examination and treatment of 156 patients who received treatment for extended benign esophageal strictures after corrosive injuries in the department of diseases of the esophagus and the gastrointestinal tract of the State Institution "V. T. Zaitsev Institute of General and Urgent Surgery of NAMS of Ukraine" for the period from 2000 to 2016. Surgical treatment by the developed in our hospital technique performed in the patients of the main group and the classical methods of surgery were used in the patients of comparison group...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905305/dysplasia-detection-in-barrett-s-esophagus-by-use-of-volumetric-laser-endomicroscopy-with-laser-marking
#12
Arvind J Trindade, Sumant Inamdar, Divyesh V Sejpal
No abstract text is available yet for this article.
September 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29904747/a-rapid-computational-approach-for-assessing-interfraction-esophageal-motion-for-use-in-stereotactic-body-radiation-therapy-planning
#13
Michael L Cardenas, Thomas R Mazur, Christina I Tsien, Olga L Green
Purpose: We present a rapid computational method for quantifying interfraction motion of the esophagus in patients undergoing stereotactic body radiation therapy on a magnetic resonance (MR) guided radiation therapy system. Methods and materials: Patients who underwent stereotactic body radiation therapy had simulation computed tomography (CT) and on-treatment MR scans performed. The esophagus was contoured on each scan. CT contours were transferred to MR volumes via rigid registration...
April 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29904493/esophageal-lung-with-rare-associated-vascular-and-anorectal-malformations
#14
Ali Alsaadi, Hamdi A Alsufiani, Mohammad D Allugmani, Altaf Hussain Gora
Esophageal lung is a rare communicating bronchopulmonary foregut malformation in which the main bronchus arising from the trachea is absent. The affected lung is usually hypoplastic and aerated via an anomalous airway originating from the esophagus. Other anomalies such as esophageal atresia with tracheoesophageal fistula or VACTERL (vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, and limb abnormalities) association can co-exist. The initial radiographic findings may be normal, but subsequent imaging usually shows progressive and recurrent lung collapse, probably because of recurrent aspiration through the anomalous airway and poor compliance of the affected lung during breathing...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29904099/genetic-variants-at-the-16p13-locus-confer-risk-for-eosinophilic-esophagitis
#15
Leah C Kottyan, Avery Maddox, Julian R Braxton, Emily M Stucke, Vince Mukkada, Philip E Putnam, J Pablo Abonia, Mirna Chehade, Robert A Wood, Robbie D Pesek, Brian P Vickery, Glenn T Furuta, Peter Dawson, Hugh A Sampson, Lisa J Martin, Jennifer A Kelly, Robert P Kimberly, Kathy Sivils, Patrick M Gaffney, Kenneth Kaufman, John B Harley, Marc E Rothenberg
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus triggered by immune hypersensitivity to food. Herein, we tested whether genetic risk factors for known, non-allergic, immune-mediated diseases, particularly those involving autoimmunity, were associated with EoE risk. We used the high-density Immunochip platform, encoding 200,000 genetic variants for major auto-immune disease. Accordingly, 1214 subjects with EoE of European ancestry and 3734 population controls were genotyped and assessed using data directly generated or imputed from the previously published GWAS...
June 8, 2018: Genes and Immunity
https://www.readbyqxmd.com/read/29903507/timing-of-esophagectomy-after-neoadjuvant-chemoradiation-treatment-in-squamous-cell-carcinoma
#16
Jan Franko, Sarah McAvoy
BACKGROUND: Time interval between neoadjuvant (combined) chemotherapy and radiation (nCRT) and surgery has been linked to pathologic response rates and outcomes in patients with various solid cancers. The optimal timing between nCRT and esophagectomy in patients with esophageal squamous cell carcinoma (SCC), however, is not known. Our aim was to analyze the relation between elapsed time from completion of nCRT to esophagectomy and postsurgical mortality and overall survival. METHODS: We reviewed the National Cancer Database for patients with SCC (n = 1,244) of the esophagus diagnosed between 2003 and 2011 who were treated with nCRT followed by esophagectomy within 26 weeks after completion of nCRT...
June 11, 2018: Surgery
https://www.readbyqxmd.com/read/29902646/factors-associated-with-recurrence-of-barrett-s-esophagus-after-radiofrequency-ablation
#17
Mimi C Tan, Kavin A Kanthasamy, Allison G Yeh, Daniel Kil, Lisa Pompeii, Xiaoying Yu, Hashem B El-Serag, Aaron P Thrift
BACKGROUND & AIMS: Radiofrequency ablation (RFA) is effective treatment for Barrett's esophagus (BE). However, some patients have recurrence after complete eradication of intestinal metaplasia (CEIM). We investigated the incidence of and factors associated with BE recurrence, with or without neoplasia, after RFA and CEIM using data from the national Veterans Affairs (VA) healthcare system. METHODS: We performed a retrospective cohort study of Veterans with BE treated by RFA from 2005 through 2016 with follow-up endoscopy...
June 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29902643/a-rare-case-of-hyperplastic-proximal-esophageal-polyps-with-foveolar-dysplasia
#18
Maham Hayat, Sultan Mahmood, John T Maple
A 62-year-old male with long-standing esophageal reflux underwent endoscopy at an outside institution that reported multiple polypoid lesions in upper esophagus and a small focal area of nodular mucosa at the gastroesophageal junction(GEJ). Biopsies of the proximal esophageal polyps demonstrated hyperplastic mucosa with ulceration, reactive epithelial changes, and focal intestinal metaplasia. Biopsies from the nodular GEJ mucosa were described as Barrett's esophagus with low grade dysplasia. An upper endoscopy performed at our medical center found multiple semi-pedunculated esophageal polyps between 18-24 cm from the incisors (Figure A)...
June 11, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29902066/cholecystokinin-induces-esophageal-longitudinal-muscle-contraction-and-transient-lower-esophageal-sphincter-relaxation-in-healthy-humans
#19
Arash Babaei, Ravinder K Mittal
Cholecystokinin (CCK) is known to cause lower esophageal sphincter (LES) relaxation through the activation of inhibitory motor neurons. Recent studies show that the longitudinal muscle contraction (LMC) related axial stretch may play a role in the LES relaxation. The aim of our study was to determine whether the CCK induced LES relaxation and identify the characteristics of associated LMC in humans. Nine healthy volunteers (5F, 40 + 12 years) received escalating doses of CCK-octapeptide (5, 10, 20 and 40 ng/kg)...
June 14, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29901650/surgery-combined-with-radio-chemotherapy-for-esophageal-mucoepidermoid-carcinoma-a-case-report
#20
Chunhui Zheng, Xiaomei Chen, Fangbiao Zhang, Liping Yan, Xiangyan Zhang
RATIONALE: Primary mucoepidermoid carcinoma (MEC) of the esophagus is a rare type of malignant neoplasm. Its morphology resembles that of MEC of the salivary glands. It is characterized by a diffuse mixture of squamous and mucus-secreting glandular carcinoma cells. Due to the low incidence of esophageal MEC, the biological behavior and treatment of this tumor have not been well studied. PATIENT CONCERNS: In this case report, we describe a case of a 59-year-old man who presented with difficulty in swallowing...
June 2018: Medicine (Baltimore)
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