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Early intervention psychosis

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https://www.readbyqxmd.com/read/28325573/brain-network-characteristics-separating-individuals-at-clinical-high-risk-for-psychosis-into-normality-or-psychosis
#1
Soo-Hee Choi, Sunghyon Kyeong, Kang Ik K Cho, Je-Yeon Yun, Tae Young Lee, Hye Yoon Park, Sung Nyun Kim, Jun Soo Kwon
We aimed to separate individuals at clinical high risk for psychosis (CHR) state into subgroups according to neurobiological characteristics using structural and functional network constructs and examine their clinical characteristics. Structural diffusion tensor imaging and resting-state functional magnetic resonance imaging were performed in 61 healthy controls (HC), 57 individuals at CHR and 29 patients with schizophrenia (SZ). The main outcome was a likelihood ratio calculated from measures of structural and functional network efficiencies, coupling strength of structural and functional networks, and a disease-specific data analysis, resulting in the most probable classification of CHR into HC or SZ...
March 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28321193/early-psychosis-and-trauma-related-disorders-clinical-practice-guidelines-and-future-directions
#2
Casey A Cragin, Martha B Straus, Dawn Blacker, Laura M Tully, Tara A Niendam
Despite high rates of trauma-related disorders among individuals with early psychosis, no clinical practice guidelines for the treatment of comorbid early psychosis and trauma-related disorders exist to date. Indeed, the routine exclusion of individuals with past and current psychosis from participation in trauma research and practice has limited the accumulation of research that could support such clinical practice guidelines. While preliminary research evidence suggests that traditional, evidence-based treatments for trauma-related disorders can be safely and effectively employed to reduce symptoms of posttraumatic stress and chronic psychosis, it remains unclear whether such treatments are appropriate for individuals in the early stages of psychotic illness...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28320226/functional-neuroimaging-predictors-of-self-reported-psychotic-symptoms-in-adolescents
#3
Josiane Bourque, Philip A Spechler, Stéphane Potvin, Robert Whelan, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère-Martinot, Sarah C McEwen, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Michael N Smolka, Nora C Vetter, Henrik Walter, Gunter Schumann, Hugh Garavan, Patricia J Conrod
OBJECTIVE: This study investigated the neural correlates of psychotic-like experiences in youths during tasks involving inhibitory control, reward anticipation, and emotion processing. A secondary aim was to test whether these neurofunctional correlates of risk were predictive of psychotic symptoms 2 years later. METHOD: Functional imaging responses to three paradigms-the stop-signal, monetary incentive delay, and faces tasks-were collected in youths at age 14, as part of the IMAGEN study...
March 21, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28318837/innovations-in-first-episode-psychosis-interventions-the-case-for-a-raise-plus-approach
#4
Emily Kline, Matcheri Keshavan
Several papers in the current issue of Schizophrenia Research show evidence supporting interventions that are not yet grouped with standard care practices in FEP. Taken together, these studies make the case for a more inclusive approach for early psychosis care than what is embodied in RAISE. Although providing all interventions to all patients, however, will be impractical and expensive, a personalized approach to such interventions, whereby the appropriate interventions are implemented in a phase specific and individually tailored manner after a careful assessment of each person's core deficits within a coordinated specialty care model, is likely to improve lives and be cost-effective...
March 17, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28302703/predictors-and-moderators-of-treatment-outcome-in-patients-receiving-multi-element-psychosocial-intervention-for-early-psychosis-results-from-the-get-up-pragmatic-cluster-randomised-controlled-trial
#5
Antonio Lasalvia, Chiara Bonetto, Jacopo Lenzi, Paola Rucci, Laura Iozzino, Massimo Cellini, Carla Comacchio, Doriana Cristofalo, Armando D'Agostino, Giovanni de Girolamo, Katia De Santi, Daniela Ghigi, Emanuela Leuci, Maurizio Miceli, Anna Meneghelli, Francesca Pileggi, Silvio Scarone, Paolo Santonastaso, Stefano Torresani, Sarah Tosato, Angela Veronese, Angelo Fioritti, Mirella Ruggeri
BackgroundThe GET UP multi-element psychosocial intervention proved to be superior to treatment as usual in improving outcomes in patients with first-episode psychosis (FEP). However, to guide treatment decisions, information on which patients may benefit more from the intervention is warranted.AimsTo identify patients' characteristics associated with (a) a better treatment response regardless of treatment type (non-specific predictors), and (b) a better response to the specific treatment provided (moderators)...
March 16, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28302699/psychological-and-psychosocial-interventions-for-negative-symptoms-in-psychosis-systematic-review-and-meta-analysis
#6
REVIEW
Danyael Lutgens, Genevieve Gariepy, Ashok Malla
BackgroundNegative symptoms observed in patients with psychotic disorders undermine quality of life and functioning. Antipsychotic medications have a limited impact. Psychological and psychosocial interventions, with medication, are recommended. However, evidence for the effectiveness of specific non-biological interventions warrants detailed examination.AimsTo conduct a meta-analytic and systematic review of the literature on the effectiveness of non-biological treatments for negative symptoms in psychotic disorders...
March 16, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28294477/identifying-neurocognitive-markers-for-outcome-prediction-of-global-functioning-in-ultra-high-risk-for-psychosis-and-first-episode-psychosis
#7
Kingo Sawada, Akiko Kanehara, Satoshi Eguchi, Mariko Tada, Yoshihiro Satomura, Motomu Suga, Shinsuke Koike, Kiyoto Kasai
AIM: There is an increasing need for identifying neurocognitive predictors of global functional outcome in early psychosis toward optimizing early intervention strategy. METHODS: We conducted a longitudinal observational study to investigate an association between neurocognitive assessments at baseline and global functional outcome at an average of one-year follow-up. Participants included ultra-high-risk for psychosis (UHR) individuals who had not converted to psychosis during the follow-up period (UHR-NP), and those with first-episode psychosis (FEP) individuals...
March 14, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28288547/neuropsychological-correlates-of-schizotypy-a-systematic-review-and-meta-analysis-of-cross-sectional-studies
#8
Sara Siddi, Donatella Rita Petretto, Antonio Preti
INTRODUCTION: Cognitive deficits can precede the onset of psychotic episodes and predict the onset of the illness in individuals with schizotypy traits. In some studies, high levels of schizotypy were associated with impairments in memory, attention, executive functions, and verbal fluency. This review provides a more comprehensive understanding of cognitive impairments related to schizoytpy. METHODS:  A systematic review of "schizotypy and neuropsychological measures" was conducted, and it retrieved 67 studies...
March 13, 2017: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/28262142/do-stress-and-support-matter-for-caring-the-role-of-perceived-stress-and-social-support-on-expressed-emotion-of-carers-of-persons-with-first-episode-psychosis
#9
Anvar Sadath, D Muralidhar, Shivarama Varambally, B N Gangadhar, Justin P Jose
BACKGROUND: Caring for a person with first episode psychosis (FEP) is a challenging and distressing task for the carers. The carers' stress in the early stage of psychosis can increase their expressed emotion (EE) while social support is hypothesized to decrease EE. However, the influence of stress and social support on carers' EE is not well understood in FEP. AIM: To examine how the stress and social support shape expressed emotion in the carers of FEP. METHODS: Seventy one carers of the patients with non-affective FEP were recruited from the inpatient psychiatry ward of a tertiary mental health care center in South India...
February 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28235902/five-years-of-specialised-early-intervention-versus-two-years-of-specialised-early-intervention-followed-by-three-years-of-standard-treatment-for-patients-with-a-first-episode-psychosis-randomised-superiority-parallel-group-trial-in-denmark-opus-ii
#10
https://www.readbyqxmd.com/read/28223807/the-relationship-between-childhood-trauma-and-adult-psychosis-in-a-uk-early-intervention-service-results-of-a-retrospective-case-note-study
#11
Francesca D Reeder, Nusrat Husain, Abdul Rhouma, Peter M Haddad, Tariq Munshi, Farooq Naeem, Davit Khachatryan, Imran B Chaudhry
AIM: There is evidence that childhood trauma is a risk factor for the development of psychosis and it is recommended that childhood trauma is inquired about in all patients presenting with psychosis. This study aimed to determine the prevalence of childhood trauma in patients in the UK Early Intervention Service based on a case note review. METHODS: This is a retrospective case note study of 296 patients in an UK Early Intervention Service. Trauma history obtained on service entry was reviewed and trauma experienced categorized...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28213813/waiting-time-variation-in-early-intervention-psychosis-services-longitudinal-evidence-from-the-sepea-naturalistic-cohort-study
#12
James B Kirkbride, Y Hameed, L Wright, K Russell, C Knight, J Perez, P B Jones
PURPOSE: Early Intervention Psychosis [EIP] services have gained traction internationally, but are currently undergoing various forms of reconfiguration. In England, such services are now mandated to ensure 50% of accepted referrals commence care within 14 days, but no empirical evidence exists. We sought to estimate waiting times to EIP services in a large, representative epidemiological cohort in England, and investigate possible reasons for any variation. METHODS: We estimated median waiting time from referral to acceptance by EIP services and investigated whether this varied by clinical, demographic or neighbourhood-level factors, amongst 798 participants, 16-35 years old, presenting to six EIP services over 3...
February 18, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28196549/mental-health-related-stigma-and-pathways-to-care-for-people-at-risk-of-psychotic-disorders-or-experiencing-first-episode-psychosis-a-systematic-review
#13
P C Gronholm, G Thornicroft, K R Laurens, S Evans-Lacko
BACKGROUND: Stigma associated with mental illness can delay or prevent help-seeking and service contact. Stigma-related influences on pathways to care in the early stages of psychotic disorders have not been systematically examined. METHOD: This review systematically assessed findings from qualitative, quantitative and mixed-methods research studies on the relationship between stigma and pathways to care (i.e. processes associated with help-seeking and health service contact) among people experiencing first-episode psychosis or at clinically defined increased risk of developing psychotic disorder...
February 15, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28188388/longer-duration-of-untreated-psychosis-hinders-improvement-in-treatment-of-chronic-schizophrenia-community-based-early-intervention-is-an-evidence-based-option
#14
Abdülkadir Tabo, Erkan Aydın, Hüseyin Yumrukçal, Sadık Yiğit, Uğraş Erman Uzun, Oğuz Karamustafalıoğlu
To determine the effects of community-based mental health services on the quality of life and disease symptoms of chronic schizophrenia patients and to determine the effects of duration of untreated psychosis on outcome. The first year records of schizophrenia patients who had been followed up at Zeytinburnu CMHC for at least 12 months, have been used to asses outcome using initial and 12th month quality of life (QoL), positive and negative symptom scale (PANSS) scores. Highly significant improvements were shown in the QoL and PANSS scores...
February 10, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28184308/the-access-and-waiting-time-standard-for-first-episode-psychosis-an-opportunity-for-identification-and-treatment-of-psychosis-risk-states
#15
EDITORIAL
Richard Whale, Andrew Thompson, Rick Fraser
Expansion of early intervention services to identify and clinically manage at-risk mental state for psychosis has been recently commissioned by NHS England. Although this is a welcome development for preventive psychiatry, further clarity is required on thresholds for definition of such risk states and their ability to predict subsequent outcomes. Intervention studies for these risk states have demonstrated that a variety of interventions, including those with fewer adverse effects than antipsychotic medication, may potentially be effective but they should be interpreted with caution...
February 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28177191/development-of-an-implementation-guide-to-facilitate-the-roll-out-of-early-intervention-services-for-psychosis
#16
Sarah E Hetrick, Denise A O'Connor, Heather Stavely, Frank Hughes, Kerryn Pennell, Eoin Killackey, Patrick D McGorry
AIM: Our aim was to develop an implementation guide that was informed by an analysis of context-specific barriers and enablers, behaviour change theory, as well as evidence about the effects of implementation interventions, for the establishment and scaling up of an early intervention model for psychosis (called Early Psychosis Prevention and Intervention Centre (EPPIC)). METHODS: We used a systematic approach involving four steps. First, the target behaviours of the EPPIC model for implementation were specified...
February 8, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28169087/adolescents-at-clinical-high-risk-for-psychosis-circadian-rhythm-disturbances-predict-worsened-prognosis-at-1-year-follow-up
#17
Jessica R Lunsford-Avery, Bruno da Silva Brandão Gonçalves, Elisa Brietzke, Rodrigo A Bressan, Ary Gadelha, Randy P Auerbach, Vijay A Mittal
BACKGROUND: Individuals with psychotic disorders experience disruptions to both the sleep and circadian components of the sleep/wake cycle. Recent evidence has supported a role of sleep disturbances in emerging psychosis. However, less is known about how circadian rhythm disruptions may relate to psychosis symptoms and prognosis for adolescents with clinical high-risk (CHR) syndromes. The present study examines circadian rest/activity rhythms in CHR and healthy control (HC) youth to clarify the relationships among circadian rhythm disturbance, psychosis symptoms, psychosocial functioning, and the longitudinal course of illness...
February 4, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28166760/can-cognitive-insight-predict-symptom-remission-in-a-first-episode-psychosis-cohort
#18
Jennifer A O'Connor, Lyn Ellett, Olesya Ajnakina, Tabea Schoeler, Anna Kollliakou, Antonella Trotta, Benjamin D Wiffen, Aurora M Falcone, Marta Di Forti, Robin M Murray, Sagnik Bhattacharyya, Anthony S David
BACKGROUND: The outcome of first episode psychosis (FEP) is highly variable and difficult to predict. Cognitive insight measured at illness onset has previously been found to predict psychopathology 12-months later. The aims of this study were to examine whether the prospective relationship between cognitive insight and symptom severity is evident at four-years following FEP and to examine some psychological correlates of cognitive insight. METHODS: FEP participants (n = 90) completed the Beck Cognitive Insight Scale (BCIS) at illness onset, and associations between BCIS scores with symptom severity outcomes (4-years after FEP) were assessed...
February 6, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28124827/examination-of-cultural-competence-in-service-providers-in-an-early-intervention-programme-for-psychosis-in-montreal-quebec-perspectives-of-service-users-and-treatment-providers
#19
Shruthi Venkataraman, Gerald Jordan, Megan A Pope, Srividya N Iyer
AIM: To better understand cultural competence in early intervention for psychosis, we compared service users' and service providers' perceptions of the importance of providers being culturally competent and attentive to aspects of culture. METHODS: At a Canadian early intervention programme, a validated scale was adapted to assess service user (N = 51) and provider (N = 30) perceptions of service providers' cultural competence and the importance accorded thereto...
January 26, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28124473/who-needs-aesop-predicting-long-term-readmission-rates-from-routine-early-intervention-team-discharge-information
#20
Matthew J Taylor, Tania Blanco Pena, Rocio Perez-Iglesias
AIM: Prognosis following early psychosis is highly variable. Long-term prognostic information from research studies is available in only a few areas. We sought to understand how well routine discharge information allows prediction of long-term readmission prognosis. METHODS: We reviewed the records of 239 people leaving Early Intervention services, after an average of 2.5 years, and counted the number of relapses. The distribution was modelled and extrapolated to a predicted 10 year outcome...
January 26, 2017: Early Intervention in Psychiatry
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