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Early intervention psychosis

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https://www.readbyqxmd.com/read/27893018/effect-of-%C3%AF-3-polyunsaturated-fatty-acids-in-young-people-at-ultrahigh-risk-for-psychotic-disorders-the-neurapro-randomized-clinical-trial
#1
Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok Pan Yuen, Miriam R Schäfer, Nilufar Mossaheb, Monika Schlögelhofer, Stephan Smesny, Ian B Hickie, Gregor Emanuel Berger, Eric Y H Chen, Lieuwe de Haan, Dorien H Nieman, Merete Nordentoft, Anita Riecher-Rössler, Swapna Verma, Andrew Thompson, Alison Ruth Yung, G Paul Amminger
Importance: A promising treatment to prevent onset and improve outcomes in patients at ultrahigh risk for psychosis is dietary supplementation with long-chain ω-3 polyunsaturated fatty acids (PUFAs). Objective: To determine whether treatment with ω-3 PUFAs in combination with a high-quality psychosocial intervention (cognitive behavioral case management [CBCM]) is more effective than placebo plus CBCM. Design, Setting, and Participants: NEURAPRO, a double-blind, placebo-controlled, randomized clinical trial, was conducted from March 1, 2010, to September 30, 2014, in 10 specialized early psychosis treatment services in Australia, Asia, and Europe...
November 23, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27891188/associations-between-social-cognition-skills-and-function-and-subclinical-negative-and-positive-symptoms-in-22q11-2-deletion-syndrome
#2
A Vangkilde, J R M Jepsen, H Schmock, C Olesen, S Arnarsdóttir, W F C Baaré, K J Plessen, M Didriksen, H R Siebner, T Werge, L Olsen
BACKGROUND: Identification of the early signs of schizophrenia would be a major achievement for the early intervention and prevention strategies in psychiatry. Social impairments are defining features of schizophrenia. Impairments of individual layers of social competencies are frequently described in individuals with 22q11.2 deletion syndrome (22q11.2DS), who have high risk of schizophrenia. It is unclear whether and to what extent social impairments associate with subclinical negative and positive symptoms in 22q11...
2016: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/27888973/comparison-of-caregiver-burden-in-first-episode-versus-chronic-psychosis
#3
Perihan Sagut, Zekiye Çetinkaya Duman
The aim of this study was to compare burden on caregivers of patients with first episode psychosis and caregivers of those with chronic psychosis. The study sample consisted of 39 caregivers of patients with first episode psychosis and 40 caregivers of patients with chronic psychosis. The Caregiver Burden Inventory (CBI) was used for data collection. The average caregiver burden in caregivers of patients with chronic psychosis was significantly higher than that in caregivers of patients with first episode psychosis...
December 2016: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/27888680/symptomatic-and-functional-outcomes-of-substance-use-disorder-persistence-2-years-after-admission-to-a-first-episode-psychosis-program
#4
Amal Abdel-Baki, Clairélaine Ouellet-Plamondon, Émilie Salvat, Kawthar Grar, Stéphane Potvin
Substance use disorders (SUD) in first-episode psychosis (FEP) are highly prevalent and linked with poor outcomes. However, most longitudinal studies investigating their impacts in FEP have not reported proportions of patients who ceased SUD. Our aim was to examine the influence of SUD course on functional and symptomatic outcomes as well as service use in FEP. We performed a 2-year longitudinal study of 212 FEP patients, aged between 18 and 30 years, admitted to 2 early psychosis services in Montréal, Québec, Canada...
November 10, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27885664/haloperidol-plus-promethazine-for-psychosis-induced-aggression
#5
REVIEW
Gisele Huf, Jacob Alexander, Pinky Gandhi, Michael H Allen
BACKGROUND: Health services often manage agitated or violent people, and such behaviour is particularly prevalent in emergency psychiatric services (10%). The drugs used in such situations should ensure that the person becomes calm swiftly and safely. OBJECTIVES: To examine whether haloperidol plus promethazine is an effective treatment for psychosis-induced aggression. SEARCH METHODS: On 6 May 2015 we searched the Cochrane Schizophrenia Group's Register of Trials, which is compiled by systematic searches of major resources (including MEDLINE, EMBASE, AMED, BIOSIS, CINAHL, PsycINFO, PubMed, and registries of clinical trials) and their monthly updates, handsearches, grey literature, and conference proceedings...
November 25, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27871281/physical-multimorbidity-and-psychosis-comprehensive-cross-sectional-analysis-including-242-952-people-across-48-low-and-middle-income-countries
#6
Brendon Stubbs, Ai Koyanagi, Nicola Veronese, Davy Vancampfort, Marco Solmi, Fiona Gaughran, André F Carvalho, John Lally, Alex J Mitchell, James Mugisha, Christoph U Correll
BACKGROUND: In people with psychosis, physical comorbidities, including cardiovascular and metabolic diseases, are highly prevalent and leading contributors to the premature mortality encountered. However, little is known about physical health multimorbidity in this population or in people with subclinical psychosis and in low- and middle-income countries (LMICs). This study explores physical health multimorbidity patterns among people with psychosis or subclinical psychosis. METHODS: Overall, data from 242,952 individuals from 48 LMICs, recruited via the World Health Survey, were included in this cross-sectional study...
November 22, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27869058/relationship-of-amotivation-to-neurocognition-self-efficacy-and-functioning-in-first-episode-psychosis-a-structural-equation-modeling-approach
#7
W C Chang, V W Y Kwong, C L M Hui, S K W Chan, E H M Lee, E Y H Chen
BACKGROUND: Better understanding of the complex interplay among key determinants of functional outcome is crucial to promoting recovery in psychotic disorders. However, this is understudied in the early course of illness. We aimed to examine the relationships among negative symptoms, neurocognition, general self-efficacy and global functioning in first-episode psychosis (FEP) patients using structural equation modeling (SEM). METHOD: Three hundred and twenty-one Chinese patients aged 26-55 years presenting with FEP to an early intervention program in Hong Kong were recruited...
November 21, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27866482/insight-as-a-social-identity-process-in-the-evolution-of-psychosocial-functioning-in-the-early-phase-of-psychosis
#8
H S Klaas, A Clémence, R Marion-Veyron, J-P Antonietti, L Alameda, P Golay, P Conus
BACKGROUND: Awareness of illness (insight) has been found to have contradictory effects for different functional outcomes after the early course of psychosis. Whereas it is related to psychotic symptom reduction and medication adherence, it is also associated with increased depressive symptoms. In this line, the specific effects of insight on the evolution of functioning over time have not been identified, and social indicators, such as socio-occupational functioning have barely been considered...
November 21, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27864791/the-harms-of-antipsychotic-drugs-evidence-from-key-studies
#9
Thomas J Moore, Curt D Furberg
This safety assessment provides a detailed analysis of key studies and focuses on the six most widely used antipsychotic drugs. Lines of evidence include mechanisms of action, short-term treatment of psychosis, relapse prevention, early intervention in schizophrenia, long-term comparisons between first- and second-generation agents, and flexible treatment algorithms. Despite the diversity of study settings, several common features were seen. All the agents obstruct normal signaling through widely dispersed dopamine D2 receptors...
November 19, 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27863320/the-effect-of-childhood-adversity-on-4-year-outcome-in-individuals-at-ultra-high-risk-for-psychosis-in-the-dutch-early-detection-intervention-evaluation-edie-nl-trial
#10
Tamar C Kraan, Helga K Ising, Marjolein Fokkema, Eva Velthorst, David P G van den Berg, Margot Kerkhoven, Wim Veling, Filip Smit, Don H Linszen, Dorien H Nieman, Lex Wunderink, Nynke Boonstra, Rianne M C Klaassen, Sara Dragt, Judith Rietdijk, Lieuwe de Haan, Mark van der Gaag
Childhood adversity is associated with a range of mental disorders, functional impairment and higher health care costs in adulthood. In this study we evaluated if childhood adversity was predictive of adverse clinical and functional outcomes and health care costs in a sample of patients at ultra-high risk (UHR) for developing a psychosis. Structural Equation Modeling was used to examine the effect of childhood adversity on depression, anxiety, transition to psychosis and overall functioning at 4-year follow-up...
November 11, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27863046/early-psychosis-intervention-outpatient-service-of-the-1st-psychiatric-university-clinic-in-athens-3-years-of-experience
#11
Constantinos Kollias, Lida-Alkisti Xenaki, Stefanos Dimitrakopoulos, Ioannis Kosteletos, Vassilis Kontaxakis, Nikos Stefanis, Charalampos Papageorgiou
To present the 3-year experience of the early intervention in psychosis (EIP) service implementation of the 1st Psychiatric University Clinic in Athens. An overview of: (1) the purpose of our service, (2) the referral network, (3) the selection criteria, (4) the diagnostic procedures, (5) the therapeutic interventions and (6) the research activities. The service was established in 2012 and developed gradually aiming to provide information, early detection, treatment and support to people aged 15 to 40 years with psychotic manifestations, who are either at increased risk of developing psychosis (at-risk mental state [ARMS]) or with first episode psychosis (FEP)...
November 9, 2016: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/27860369/factor-structure-of-therapist-fidelity-to-individual-resiliency-training-in-the-recovery-after-an-initial-schizophrenia-episode-early-treatment-program
#12
Julia Browne, Alexandra N Edwards, David L Penn, Piper S Meyer-Kalos, Jennifer D Gottlieb, Paul Julian, Kelsey Ludwig, Kim T Mueser, John M Kane
BACKGROUND: Evidence-based approaches and early intervention have improved the long-term prognosis of individuals with schizophrenia. However, little is known about the therapeutic processes involved in individual therapy in first-episode psychosis. A comprehensive psychosocial/psychiatric programme for this population, NAVIGATE, includes an individual therapy component, individual resiliency training (IRT). Fidelity of clinicians' adherence to the IRT protocol has been collected to ensure proper implementation of this manual-based intervention...
November 9, 2016: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/27860281/counting-up-the-risks-how-common-are-risk-factors-for-morbidity-and-mortality-in-young-people-with-psychosis
#13
Lisa Anne Hahn, Andrew Mackinnon, Debra L Foley, Vera A Morgan, Anna Waterreus, Gerald F Watts, David J Castle, Dennis Liu, Cherrie A Galletly
BACKGROUND: This study examined the prevalence of risk factors for cardiovascular (CV)-related morbidity and mortality in young people with psychosis aged 18 to 24 years. METHODS: The study included 132 people aged 18 to 24 years who participated in the 2010 second Australian national survey of people living with psychosis. The 2009 World Health Organisation (WHO) Global Health Risks report was used as a framework to determine which specific risk factors were present in each in these young people...
November 17, 2016: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/27853241/supplementation-with-d-serine-prevents-the-onset-of-cognitive-deficits-in-adult-offspring-after-maternal-immune-activation
#14
Yuko Fujita, Tamaki Ishima, Kenji Hashimoto
Prenatal maternal infection contributes to the etiology of schizophrenia, with D-serine, an endogenous co-agonist of the N-methyl-D-aspartate (NMDA) receptor, playing a role in the pathophysiology of this disease. We examined whether supplementation with D-serine during juvenile and adolescent stages could prevent the onset of cognitive deficits, prodromal and the core symptoms of schizophrenia in adult offspring after maternal immune activation (MIA). Juvenile offspring exposed prenatally to poly(I:C) showed reduced expression of NMDA receptor subunits in the hippocampus...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27835719/adjunctive-taurine-in-first-episode-psychosis-a-phase-2-double-blind-randomized-placebo-controlled-study
#15
Colin P O'Donnell, Kelly A Allott, Brendan P Murphy, Hok Pan Yuen, Tina-Marie Proffitt, Alicia Papas, Jennifer Moral, Tee Pham, Michaela K O'Regan, Christina Phassouliotis, Raelene Simpson, Patrick D McGorry
OBJECTIVE: Taurine is an inhibitory neuromodulatory amino acid in the central nervous system that activates the GABA- and glycine-insensitive chloride channel and inhibits the N-methyl-d-aspartate receptor. It also functions as a neuroprotective agent and has a role in neural development and neurogenesis. The aim of this study was to determine the efficacy of adjunctive taurine in improving symptomatology and cognition among patients with a DSM-IV first-episode psychotic disorder. METHODS: 121 patients with first-episode psychosis, aged 18-25 years, attending early intervention services consented to participate in this randomized, double-blind, placebo-controlled trial conducted from January 2007 to May 2009...
November 8, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27832221/understanding-how-postnatal-depression-screening-and-early-intervention-work-in-the-real-world-a-singaporean-perspective
#16
Theresa My Lee, Dianne Bautista, Helen Y Chen
Postnatal depression is a major public health problem with clearly established adverse effects in child outcomes. This study examines the 4-year outcomes of a screening and early intervention programme, in relation to improvement in symptoms, functioning and health quality of life. Women were prospectively recruited up to 6 months postdelivery, using the Edinburgh Postnatal Depression Scale (EPDS) as a screening tool. High-scorers (EPDS >13), were offered psychiatric consultation, and those with borderline scores (EPDS 10-12) were provided counselling, and offered follow-up phone counselling by the assigned case manager...
October 2016: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/27824776/hopes-and-expectations-regarding-genetic-testing-for-schizophrenia-among-young-adults-at-clinical-high-risk-for-psychosis
#17
Phoebe Friesen, Ryan E Lawrence, Gary Brucato, Ragy R Girgis, Lisa Dixon
Genetic tests for schizophrenia could introduce both risks and benefits. Little is known about the hopes and expectations of young adults at clinical high-risk for psychosis concerning genetic testing for schizophrenia, despite the fact that these youth could be among those highly affected by such tests. We conducted semistructured interviews with 15 young adults at clinical high-risk for psychosis to ask about their interest, expectations, and hopes regarding genetic testing for schizophrenia. Most participants reported a high level of interest in genetic testing for schizophrenia, and the majority said they would take such a test immediately if it were available...
November 2016: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/27824119/intake-of-7-8-dihydroxyflavone-during-juvenile-and-adolescent-stages-prevents-onset-of-psychosis-in-adult-offspring-after-maternal-immune-activation
#18
Mei Han, Ji-Chun Zhang, Wei Yao, Chun Yang, Tamaki Ishima, Qian Ren, Min Ma, Chao Dong, Xu-Feng Huang, Kenji Hashimoto
Prenatal infection and subsequent abnormal neurodevelopment of offspring is involved in the etiology of schizophrenia. Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, tropomyosin receptor kinase B (TrkB) signaling plays a key role in the neurodevelopment. Pregnant mice exposed to polyriboinosinic-polyribocytidylic acid [poly(I:C)] causes schizophrenia-like behavioral abnormalities in their offspring at adulthood. Here we found that the juvenile offspring of poly(I:C)-treated mice showed cognitive deficits, as well as reduced BDNF-TrkB signaling in the prefrontal cortex (PFC)...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27804008/detecting-incipient-schizophrenia-a-validation-of-the-azima-battery-in-first-episode-psychosis
#19
Hiba Zafran, Barbara Mazer, Beverlea Tallant, Gevorg Chilingaryan, Isabelle Gelinas
Early psychosis intervention aims to accurately detect adolescents and young adults at risk for major mental disorders, particularly schizophrenia, yet early biomedical diagnostic accuracy remains poor. However, phenomenological approaches focusing on eliciting and understanding the subjective experience of help-seeking youth better detect incipient schizophrenia. The Azima Battery is an occupational therapy projective assessment that uses expressive media in a standard setup, in order to phenomenologically elicit and describe the activity performance and narratives of individuals at risk of, or on, the psychotic-spectrum...
November 2, 2016: Psychiatric Quarterly
https://www.readbyqxmd.com/read/27798015/economic-impact-of-early-intervention-in-psychosis-services-results-from-a-longitudinal-retrospective-controlled-study-in-england
#20
Apostolos Tsiachristas, Tony Thomas, Jose Leal, Belinda R Lennox
OBJECTIVES: To demonstrate the costs, outcomes and economic impact of early intervention in psychosis (EIP) services. DESIGN: Longitudinal retrospective observational study of service usage and outcome data from mental health and acute care services for all those with a diagnosis of psychosis in contact with mental health services over a 3-year period (April 2010-March 2013). SETTING: Thames Valley and South Midlands region in England (region covered by Oxford Academic Health Science Network)...
October 20, 2016: BMJ Open
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