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Early intervention psychosis

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https://www.readbyqxmd.com/read/28535284/cumulative-effects-of-neighborhood-social-adversity-and-personal-crime-victimization-on-adolescent-psychotic-experiences
#1
Joanne Newbury, Louise Arseneault, Avshalom Caspi, Terrie E Moffitt, Candice L Odgers, Helen L Fisher
BACKGROUND: Little is known about the impact of urbanicity, adverse neighborhood conditions and violent crime victimization on the emergence of adolescent psychotic experiences. METHODS: Participants were from the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally-representative cohort of 2232 British twins who were interviewed about adolescent psychotic experiences at age 18. Urbanicity, neighborhood characteristics, and personal victimization by violent crime were measured during childhood and adolescence via geocoded census data, surveys of over 5000 immediate neighbors of the E-Risk participants, and interviews with participants themselves...
May 22, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28531821/examining-the-physical-health-and-lifestyle-of-young-people-at-ultra-high-risk-for-psychosis-a-qualitative-study-involving-service-users-parents-and-clinicians
#2
Rebekah Carney, Jack Cotter, Tim Bradshaw, Alison R Yung
Emerging evidence suggests young people at ultra-high risk for psychosis (UHR) are also at-risk for poor physical health, and display high rates of modifiable cardiometabolic risk factors. However, before we can develop effective interventions there is a need to understand factors affecting lifestyle choices in the UHR group. We conducted semi-structured qualitative interviews with 20 UHR individuals (50% male; mean age 21.7), 5 parents (4 mothers, 1 father), and 6 clinicians from early intervention services in the Northwest of England to identify barriers and facilitators to living a healthy lifestyle, including achieving regular exercise, eating well and refraining from excessive substance use...
May 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28529220/clinical-correlates-of-treatment-response-among-patients-with-schizophrenia-in-a-tertiary-nigerian-hospital
#3
Mark Sunday Ezeme, Richard Uwakwe, Appolos Chidi Ndukuba, Monday N Igwe, Paul Chigozie Odinka, Kennedy Amadi, Nichodemus O Obayi
A significant proportion of patients treated for schizophrenia respond poorly to medication. Few studies have systematically examined the impact of clinical characteristics of patients to antipsychotic response in our environment. The study aimed to identify clinical variables associated with response in patients with schizophrenia. A total of 172 participants diagnosed with schizophrenia, placed on antipsychotics, who presented for the first time to the hospital or have stopped medication in the preceding six months, whose responses were assessed after four to six weeks were studied...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28528196/a-review-of-psychiatric-co-morbidity-described-in-genetic-and-immune-mediated-movement-disorders
#4
REVIEW
K J Peall, M S Lorentzos, I Heyman, M A J Tijssen, M J Owen, R C Dale, M A Kurian
Psychiatric symptoms are an increasingly recognised feature of movement disorders. Recent identification of causative genes and autoantibodies has allowed detailed analysis of aetiologically homogenous subgroups, thereby enabling determination of the spectrum of psychiatric symptoms in these disorders. This review evaluates the incidence and type of psychiatric symptoms encountered in patients with movement disorders. A broad spectrum of psychiatric symptoms was identified across all subtypes of movement disorder, with depression, generalised anxiety disorder and obsessive-compulsive disorder being most common...
May 17, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28524541/-worried-about-relapse-family-members-experiences-and-perspectives-of-relapse-in-first-episode-psychosis
#5
Shalini Lal, Ashok Malla, Gina Marandola, Joanie Thériault, Phil Tibbo, Rahul Manchanda, Richard Williams, Ridha Joober, Nicola Banks
BACKGROUND: The purpose of this study was to gain an in-depth understanding on the subject of relapse from the perspectives of family members of young people receiving services for a first-episode psychosis (FEP). METHODS: A qualitative descriptive approach, using focus group methods, was used to elicit experiences, understandings, and knowledge of relapse in FEP. Family members were recruited from 4 specialized early intervention programmes for psychosis in Canada...
May 19, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28521056/ethnic-minority-status-age-at-immigration-and-psychosis-risk-in-rural-environments-evidence-from-the-sepea-study
#6
James B Kirkbride, Yasir Hameed, Konstantinos Ioannidis, Gayatri Ankireddypalli, Carolyn M Crane, Mukhtar Nasir, Nikolett Kabacs, Antonio Metastasio, Oliver Jenkins, Ashkan Espandian, Styliani Spyridi, Danica Ralevic, Suneetha Siddabattuni, Ben Walden, Adewale Adeoye, Jesus Perez, Peter B Jones
Objective: Several ethnic minority groups experience elevated rates of first-episode psychosis (FEP), but most studies have been conducted in urban settings. We investigated whether incidence varied by ethnicity, generation status, and age-at-immigration in a diverse, mixed rural, and urban setting. Method: We identified 687 people, 16-35 years, with an ICD-10 diagnosis of FEP, presenting to Early Intervention Psychosis services in the East of England over 2 million person-years...
May 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28499766/comparing-early-signs-and-basic-symptoms-as-methods-for-predicting-psychotic-relapse-in-clinical-practice
#7
Emily Eisner, Richard Drake, Fiona Lobban, Sandra Bucci, Richard Emsley, Christine Barrowclough
BACKGROUND: Early signs interventions show promise but could be further developed. A recent review suggested that 'basic symptoms' should be added to conventional early signs to improve relapse prediction. This study builds on preliminary evidence that basic symptoms predict relapse and aimed to: 1. examine which phenomena participants report prior to relapse and how they describe them; 2. determine the best way of identifying pre-relapse basic symptoms; 3. assess current practice by comparing self- and casenote-reported pre-relapse experiences...
May 9, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28498576/a-critique-of-the-ultra-high-risk-and-transition-paradigm
#8
Jim van Os, Sinan Guloksuz
The transdiagnostic expression of psychotic experiences in common mental disorder (anxiety/depression/substance use disorder) is associated with a poorer prognosis, and a small minority of people may indeed develop a clinical picture that meets criteria for schizophrenia. However, it appears neither useful nor valid to observe early states of multidimensional psychopathology in young people through the "schizo"-prism, and apply misleadingly simple, unnecessary and inefficient binary concepts of "risk" and "transition"...
June 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28477070/rates-and-predictors-of-18-months-remission-in-an-epidemiological-cohort-of-661-patients-with-first-episode-psychosis
#9
Philippe Conus, Sue Cotton, Benno G Schimmelmann, Patrick D McGorry, Martin Lambert
OBJECTIVES: Most first episode psychosis (FEP) outcome studies are based on patient samples enrolled through an informed consent procedure, which may induce important biases. Our aim was to study the 18-month outcome of FEP in an epidemiological sample of patients treated at the Early Psychosis Prevention and Intervention Centre (EPPIC). METHODS: The files of 661 FEP patients treated for up to 18 months between 1998 and 2000 were assessed. Symptomatic remission was defined as receiving a score ≤3 on the Clinical Global Impressions (CGI) scales, and functional remission as concurrent fulfillment of occupation/employment and independent living...
May 5, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28472900/the-long-term-effects-of-antipsychotic-medication-on-clinical-course-in-schizophrenia
#10
Donald C Goff, Peter Falkai, W Wolfgang Fleischhacker, Ragy R Girgis, Rene M Kahn, Hiroyuki Uchida, Jingping Zhao, Jeffrey A Lieberman
Concerns have been raised that treatment with antipsychotic medication might adversely affect long-term outcomes for people with schizophrenia. The evidence cited for these concerns includes the association of antipsychotic treatment with brain volume reduction and with dopamine receptor sensitization, which might make patients vulnerable to relapse and illness progression. An international group of experts was convened to examine findings from clinical and basic research relevant to these concerns. Little evidence was found to support a negative long-term effect of initial or maintenance antipsychotic treatment on outcomes, compared with withholding treatment...
May 5, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28469537/rituximab-for-treatment-of-refractory-anti-nmda-receptor-encephalitis-in-a-pediatric-patient
#11
Sarah Hallowell, Esli Tebedge, Margaret Oates, Elizabeth Hand
Anti-N-methyl d-aspartate receptor (anti-NMDAR) encephalitis is a devastating disease that is increasingly being identified in both children and adults with psychosis, language disturbances, behavioral changes, and motor deficits. Currently no consensus guidelines exist for the optimal management of patients with this disease, although intravenous immune globulin (IVIG) therapy is often considered first-line pharmacotherapy. We present a case of an otherwise healthy 4 year-old-child who presented with seizures, loss of age-appropriate language skills, and behavioral changes, in whom anti-NMDAR was subsequently diagnosed...
March 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28468563/-developmental-aspects-in-the-early-detection-and-intervention-in-clinical-high-risk-states-for-psychosis
#12
Frauke Schultze-Lutter, Stefanie J Schmidt, Petra Walger, Benno G Schimmelmann
Developmental Aspects in the Early Detection and Intervention in Clinical High Risk States for Psychosis The early detection and intervention in psychoses, which are a main source of disability-adjusted life years already in children and adolescents, have made good progress within the past years. In particular the attenuated and transient positive symptoms of the ultra-high risk criteria and the basic symptom criterion "Cognitive Disturbances" open promising routes to an indicated prevention and have recently been considered as diagnostic criteria of a psychosis-risk syndrome by the European Psychiatric Association (EPA)...
May 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/28458083/cognitive-performance-is-associated-with-gray-matter-decline-in-first-episode-psychosis
#13
Kara Dempster, Ross Norman, Jean Théberge, Maria Densmore, Betsy Schaefer, Peter Williamson
Progressive loss of gray matter has been demonstrated over the early course of schizophrenia. Identification of an association between cognition and gray matter may lead to development of early interventions directed at preserving gray matter volume and cognitive ability. The present study evaluated the association between gray matter using voxel-based morphometry (VBM) and cognitive testing in a sample of 16 patients with first-episode psychosis. A simple regression was applied to investigate the association between gray matter at baseline and 80 months and cognitive tests at baseline...
April 25, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28427286/incomes-and-outcomes-social-security-disability-benefits-in-first-episode-psychosis
#14
Robert A Rosenheck, Sue E Estroff, Kyaw Sint, Haiqun Lin, Kim T Mueser, Delbert G Robinson, Nina R Schooler, Patricia Marcy, John M Kane
OBJECTIVE: Social Security Administration (SSA) disability benefits are an important source of income for people with psychoses and confer eligibility for health insurance. The authors examined the impact of coordinated specialty care on receipt of such benefits in first-episode psychosis, along with the correlates and consequences of receiving them. METHOD: The Recovery After an Initial Schizophrenia Episode-Early Treatment Program (RAISE-ETP) study, a 34-site cluster-randomized trial, compared NAVIGATE, a coordinated specialty care program, to usual community care over 2 years...
April 21, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28424105/specific-impact-of-stimulant-alcohol-and-cannabis-use-disorders-on-first-episode-psychosis-2-year-functional-and-symptomatic-outcomes
#15
C Ouellet-Plamondon, A Abdel-Baki, É Salvat, S Potvin
BACKGROUND: Many studies have concluded that cannabis use disorder (CUD) negatively influences outcomes in first-episode psychosis (FEP). However, few have taken into account the impact of concurrent misuse of other substances. METHODS: This 2-year, prospective, longitudinal study of FEP patients, aged between 18 and 30 years, admitted to early intervention programs in Montreal, Quebec, Canada, examined the specific influence of different substance use disorders (SUD) (alcohol, cannabis, cocaine, amphetamines) on service utilization, symptomatic and functional outcomes in FEP...
April 20, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28418227/barriers-and-facilitators-to-implementing-family-support-and-education-in-early-psychosis-intervention-programmes-a-systematic-review
#16
REVIEW
Avra Selick, Janet Durbin, Nhi Vu, Karen O'Connor, Tiziana Volpe, Elizabeth Lin
Family support is a core component of the Early Psychosis Intervention (EPI) model, yet it continues to have relatively low rates of implementation in practice. This paper reports results of a literature review on facilitators and barriers to delivering family interventions in EPI programmes. A search was conducted of 4 electronic databases, Medline, EMBASE, PsycINFO and Joanna Briggs, from 2000 to 2015 using terms related to early onset psychosis, family work and implementation. Four thousand four hundred and two unique studies were identified, 7 of which met inclusion criteria...
April 18, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28396643/do-family-interventions-improve-outcomes-in-early-psychosis-a-systematic-review-and-meta-analysis
#17
REVIEW
Melanie Claxton, Juliana Onwumere, Miriam Fornells-Ambrojo
Family interventions for psychosis (FIp) are effective in reducing service user relapse and carer distress in people with schizophrenia-spectrum conditions. Several treatment and best practice guidelines recommend FIp for all people with schizophrenia. However, outcome findings in relation to early psychosis groups have been inconsistent. The current paper reports a systematic review and meta-analyses of articles that evaluated FIp in early psychosis with a clearly defined comparison group. A combination of electronic database searches (using PsychINFO, Medline, and CENTRAL), citation searches and hand searches of key journals and reviews was conducted...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28395229/depressive-symptoms-and-suicidal-behavior-after-first-episode-psychosis-a-comprehensive-systematic-review
#18
REVIEW
Ricardo Coentre, Miguel Cotrim Talina, Carlos Góis, Maria Luísa Figueira
Depressive symptoms and suicidal behavior are common among patients that suffered a first-episode psychosis. We searched Web of Knowledge(SM) and Pubmed® for English and Portuguese original articles investigating prevalence of depressive symptoms and/or suicidal behavior and associated factors after first-episode psychosis. We included 19 studies from 12 countries, 7 studied depressive symptoms and 12 suicidal behavior. The findings confirm that depressive symptoms and suicidal behavior have high rates in the years after first-episode psychosis...
April 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28385705/sustainability-of-treatment-effect-of-a-3-year-early-intervention-programme-for-first-episode-psychosis
#19
Wing Chung Chang, Vivian Wing Yan Kwong, Emily Sin Kei Lau, Hon Cheong So, Corine Sau Man Wong, Gloria Hoi Kei Chan, Olivia Tsz Ting Jim, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Eric Yu Hai Chen
BackgroundEvidence indicates that the positive effects of 2-year early intervention services for psychosis are not maintained after service withdrawal. Optimal duration of early intervention in sustaining initial improved outcomes remains to be determined.AimsTo examine the sustainability of the positive effects of an extended, 3-year, early intervention programme for patients with first-episode psychosis (FEP) after transition to standard care.MethodA total of 160 patients, who had received a 2-year early intervention programme for FEP, were enrolled to a 12-month randomised-controlled trial (ClinicalTrials...
April 6, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28373685/early-neuromodulation-prevents-the-development-of-brain-and-behavioral-abnormalities-in-a-rodent-model-of-schizophrenia
#20
R Hadar, L Bikovski, M L Soto-Montenegro, J Schimke, P Maier, S Ewing, M Voget, F Wieske, T Götz, M Desco, C Hamani, J Pascau, I Weiner, C Winter
The notion that schizophrenia is a neurodevelopmental disorder in which neuropathologies evolve gradually over the developmental course indicates a potential therapeutic window during which pathophysiological processes may be modified to halt disease progression or reduce its severity. Here we used a neurodevelopmental maternal immune stimulation (MIS) rat model of schizophrenia to test whether early targeted modulatory intervention would affect schizophrenia's neurodevelopmental course. We applied deep brain stimulation (DBS) or sham stimulation to the medial prefrontal cortex (mPFC) of adolescent MIS rats and respective controls, and investigated its behavioral, biochemical, brain-structural and -metabolic effects in adulthood...
April 4, 2017: Molecular Psychiatry
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