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Early intervention psychosis

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https://www.readbyqxmd.com/read/28096883/reconsidering-clinical-staging-model-a-case-of-genetic-high-risk-for-schizophrenia
#1
Tae Young Lee, Minah Kim, Sung Nyun Kim, Jun Soo Kwon
The clinical staging model is considered a useful and practical method not only in dealing with the early stage of psychosis overcoming the debate about diagnostic boundaries but also in emerging mood disorder. However, its one limitation is that it cannot discriminate the heterogeneity of individuals at clinical high risk for psychosis, but lumps them all together. Even a healthy offspring of schizophrenia can eventually show clinical symptoms and progress to schizophrenia under the influence of genetic vulnerability and environmental stress even after the peak age of onset of schizophrenia...
January 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28096881/design-and-methodology-of-the-korean-early-psychosis-cohort-study
#2
Sung-Wan Kim, Bong Ju Lee, Jung Jin Kim, Je-Chun Yu, Kyu Young Lee, Seung-Hee Won, Seung-Hwan Lee, Seung-Hyun Kim, Shi Hyun Kang, Young-Chul Chung
The present study details the rationale and methodology of the Korean Early Psychosis Cohort Study (KEPS), which is a clinical cohort investigation of first episode psychosis patients from a Korean population. The KEPS is a prospective naturalistic observational cohort study that follows the participants for at least 2 years. This study includes patients between 18 and 45 years of age who fulfill the criteria for one of schizophrenia spectrum and other psychotic disorders according to the diagnostic criteria of DSM-5...
January 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28095998/the-feasibility-and-clinical-benefits-of-improving-facial-affect-recognition-impairments-in-schizophrenia-systematic-review-and-meta-analysis
#3
REVIEW
Natalie Bordon, Suzanne O'Rourke, Paul Hutton
BACKGROUND: People diagnosed with schizophrenia have significant difficulty accurately recognising emotions expressed by others. This may generate anomalous experiences which, if misinterpreted, could contribute to experiences of social defeat, psychotic symptoms and reduced social functioning. It remains unclear whether this impairment is responsive to non-pharmacological intervention, or what the effect of modifying it is. METHODS: We did a systematic review and meta-analysis to examine whether and to what extent facial affect recognition impairments can be improved by psychological intervention and, if so, whether this leads to improvements in psychotic symptoms and social functioning...
January 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28095883/moderated-online-social-therapy-for-carers-of-young-people-recovering-from-first-episode-psychosis-study-protocol-for-a-randomised-controlled-trial
#4
John Gleeson, Reeva Lederman, Helen Herrman, Peter Koval, Dina Eleftheriadis, Sarah Bendall, Sue M Cotton, Mario Alvarez-Jimenez
BACKGROUND: First-episode psychosis most often has its onset during late adolescence. In caring for the young person, families endure high levels of stress and depression. Meanwhile, the social networks of families often erode. Our group has previously shown that family cognitive behaviour therapy (CBT) leads to significantly improved perceived stress compared with specialist first-episode treatment as usual; however, there are well-known barriers to the dissemination of effective family interventions...
January 17, 2017: Trials
https://www.readbyqxmd.com/read/28095334/predictors-and-mediators-of-trait-anger-across-the-psychosis-continuum-the-role-of-attachment-style-paranoia-and-social-cognition
#5
Hannah Darrell-Berry, Sandra Bucci, Jasper Palmier-Claus, Richard Emsley, Richard Drake, Katherine Berry
Anger in the context of psychosis has a significant impact on treatment outcomes and serious implications for risk management. Understanding mechanisms underlying anger will improve interventions and inform strategies for prevention. This study is the first to examine the relationships between anger and key theoretical drivers across different phases of the psychosis continuum. A battery including measures of theory of mind, attachment, hostile attribution bias, paranoia and anger was administered to 174 participants (14 ultra-high risk, 20 first-episode, 20 established psychosis, 120 non-clinical participants)...
January 4, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28072643/early-life-trauma-in-hospitalized-patients-with-mood-disorders-and-its-association-with-clinical-outcomes
#6
Ajay K Parsaik, Noha Abdelgawad, Jigar K Chotalia, Scott D Lane, Teresa A Pigott
BACKGROUND: The prevalence of childhood trauma and its impact on clinical outcomes in hospitalized patients with mood disorders is unknown. We studied the frequency of childhood trauma among inpatient adults with mood disorders and its association with clinical outcomes. METHODS: Patients admitted to our hospital with a primary diagnosis of mood disorders completed the short form of the Early Trauma Inventory-Self-Report (ETISR-SF), the Sheehan Disability Scale, and the Clinician-Rated Dimensions of Psychosis Symptom Severity scale...
January 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28068828/key-differences-in-treatment-seeking-stimulant-users-attending-a-specialised-treatment-service-a-means-of-early-intervention
#7
Shalini Arunogiri, Margret Petrie, Michelle Sharkey, Dan I Lubman
OBJECTIVES: Few people who use stimulants seek clinical treatment. This study sought to describe a cohort of stimulant users who attended a stimulant-specific treatment service, Access Point, in Melbourne, Australia between 2008 and 2014. METHODS: A retrospective audit of the records of adults ( n = 175) who sought treatment for stimulant use at a stimulant-specific outpatient treatment service was conducted. RESULTS: Service users had a median age of 32 (range = 19-54)...
January 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28065484/predictors-of-favourable-outcome-in-young-people-with-a-first-episode-psychosis-without-antipsychotic-medication
#8
Philippe Conus, Sue M Cotton, Shona M Francey, Brian O'Donoghue, Benno G Schimmelmann, Patrick D McGorry, Martin Lambert
INTRODUCTION: Data from the literature suggests that some first episode psychosis (FEP) patients may recover without antipsychotic medication. There is however no reliable way to identify them. In a previous paper we found, in a cohort of 584 FEP patients, that those consistently refusing medication had poorer pre-morbid functioning, less insight, higher rate of substance use and poorer outcome. However, some medication refusers, had a favourable outcome. The study aim was to identify predictors of good short term outcome despite non-exposure to medication...
January 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28063397/clinical-and-treatment-related-determinants-of-subjective-quality-of-life-in-patients-with-first-episode-psychosis
#9
Vivian Wing Yan Kwong, Wing Chung Chang, Gloria Hoi Kei Chan, Olivia Tsz Ting Jim, Emily Sin Kei Lau, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Eric Yu Hai Chen
Subjective quality of life (SQoL) has been increasingly studied in first-episode psychosis (FEP). Prior research primarily examined the impact of psychiatric symptoms on SQoL. Relationship between treatment-related factors and SQoL is under-studied. In this study, 159 Chinese patients who had completed 2-year treatment from early intervention service in Hong Kong were recruited. Assessments on premorbid adjustment, clinical profiles including social anxiety measure, functioning, antipsychotic-induced extrapyramidal side-effects and attitude toward medication treatment were conducted...
December 27, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28059932/a-developmental-perspective-on-social-cognition-difficulties-in-youth-at-clinical-high-risk-for-psychosis
#10
Sarah Hope Lincoln, Emily M Norkett, Katherine H Frost, Joseph Gonzalez-Heydrich, Eugene J D'Angelo
After participating in this activity, learners should be better able to:• Evaluate the evolution of social cognitive abilities as a developmental process• Assess the evidence regarding social cognition difficulties in youth at clinical high risk for psychosisIndividuals at clinical high risk (CHR) for psychosis exhibit a broad range of difficulties, including impaired social cognition, which may represent a target for early identification and intervention. Several studies have examined various domains of social cognition in CHR individuals...
January 2017: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/28057432/pattern-of-cognitive-impairment-in-patients-with-parkinson-s-disease-and-psychosis-a-critical-review
#11
REVIEW
Abhishek Lenka, Shantala Hegde, Shyam Sundar Arumugham, Pramod Kumar Pal
Psychosis is one of the debilitating non-motor symptoms (NMS) of Parkinson's disease (PD). Cognitive impairment is considered to be a risk factor for emergence of psychosis in PD. Early detection of relevant cognitive impairment may serve as a predictor for development of psychosis, with implications for prevention and early intervention. However, the exact pattern of cognitive impairment associated with psychosis is not clear. In this article, we aim to critically review the literature on case-control studies in PD patients with and without psychosis in order to understand the pattern of cognitive impairment in those with psychosis...
December 29, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28053131/a-severity-based-clinical-staging-model-for-the-psychosis-prodrome-longitudinal-findings-from-the-new-york-recognition-and-prevention-program
#12
Ricardo E Carrión, Christoph U Correll, Andrea M Auther, Barbara A Cornblatt
Clinical staging improved the possibility of intervening during the psychosis prodrome to limit progression of illness. The current study aimed to validate a novel 4-stage severity-based model with a focus on clinical change over time and risk for conversion to psychosis. One hundred seventy-one individuals at clinical high risk (CHR) for psychosis were followed prospectively (3 ± 1.6 y) as part of the Recognition and Prevention (RAP) program and divided into 4 diagnostic stages according to absence/presence and severity of attenuated positive symptoms...
January 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28049620/how-do-people-experiencing-schizophrenia-spectrum-disorders-or-other-psychotic-disorders-use-the-internet-to-get-information-on-their-mental-health-literature-review-and-recommendations
#13
Murielle Villani, Viviane Kovess-Masfety
BACKGROUND: Studies show that the Internet has become an influential source of information for people experiencing serious psychiatric conditions such as schizophrenia spectrum disorders or other psychotic disorders, among which the rate of Internet users is growing, with rates ranging from 33.3% to 79.5% given the country. Between 20.5% and 56.4% of these Internet users seek mental health information. OBJECTIVE: Focusing on this population's Web searches about their mental health, this paper examines what type of content they look for and what could be the benefits and disadvantages of this navigation...
January 3, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28049079/prediction-of-motivational-impairment-12-month-follow-up-of-the-randomized-controlled-trial-on-extended-early-intervention-for-first-episode-psychosis
#14
W C Chang, V W Y Kwong, G H K Chan, O T T Jim, E S K Lau, C L M Hui, S K W Chan, E H M Lee, E Y H Chen
BACKGROUND: Amotivation is prevalent in first-episode psychosis (FEP) patients and is a major determinant of functional outcome. Prediction of amotivation in the early stage of psychosis, however, is under-studied. We aimed to prospectively examine predictors of amotivation in FEP patients in a randomized-controlled trial comparing a 1-year extension of early intervention (Extended EI, 3-year EI) with step-down psychiatric care (SC, 2-year EI). METHODS: One hundred sixty Chinese patents were recruited from a specialized EI program for FEP in Hong Kong after they have completed this 2-year EI service, randomly allocated to Extended EI or SC, and followed up for 12 months...
December 29, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28045349/first-presentation-with-psychotic-symptoms-in-a-population-based-sample
#15
Gregory E Simon, Karen J Coleman, Bobbi Jo H Yarborough, Belinda Operskalski, Christine Stewart, Enid M Hunkeler, Frances Lynch, David Carrell, Arne Beck
OBJECTIVE: Increasing evidence supports the effectiveness of comprehensive early intervention at first onset of psychotic symptoms. Implementation of early intervention programs will require population-based data on overall incidence of psychotic symptoms and on care settings of first presentation. METHODS: In five large health care systems, electronic health records data were used to identify all first occurrences of psychosis diagnoses among persons ages 15-59 between January 1, 2007, and December 31, 2013 (N=37,843)...
January 3, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/28041918/prediction-of-functional-outcome-in-young-patients-with-a-recent-onset-psychiatric-disorder-beyond-the-traditional-diagnostic-classification-system
#16
Amedeo Minichino, Marta Francesconi, Ricardo E Carrión, Arturo Bevilacqua, Maurizio Parisi, Santo Rullo, Agata Ando', Massimo Biondi, Roberto Delle Chiaie, Kristin Cadenhead
A critical research goal is to identify modifiable risk factors leading to functional disabilities in young psychiatric patients. The authors developed a multidimensional trans-diagnostic predictive model of functional outcome in patients with the recent-onset of a psychiatric illness. Baseline clinical, psychosis-risk status, cognitive, neurological-soft-signs measures, and dopamine-related-gene polymorphisms (DRD1-rs4532, COMT-rs165599, and DRD4-rs1800955) were collected in 138 young non-psychotic outpatients...
December 29, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/28040575/stigma-toward-psychosis-and-its-formulation-process-prejudice-and-discrimination-against-early-stages-of-schizophrenia
#17
Yoko Baba, Takahiro Nemoto, Naohisa Tsujino, Taiju Yamaguchi, Naoyuki Katagiri, Masafumi Mizuno
BACKGROUND: Stigma toward psychosis can prevent social attendance and help-seeking behavior. Early detection and intervention has been shown to improve patient outcome in schizophrenia. The aim of this study was to reveal the characteristics and formulation process of stigma toward each clinical stage of schizophrenia, taking people's backgrounds into consideration. METHODS: The participants consisted of three groups: general public, patients with mental illness, and psychiatric professionals...
November 17, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28038921/community-treatment-order-identifying-the-need-for-more-evidence-based-justification-of-its-use-in-first-episode-psychosis-patients
#18
Stéphane Morandi, Philippe Golay, Martin Lambert, Benno G Schimmelmann, Patrick D McGorry, Sue M Cotton, Philippe Conus
OBJECTIVES: Community Treatment Order (CTO) is a legal regime that obliges patients suffering mental disorder to adhere to treatment in the community and allows for a swift admission to hospital if necessary. Study aims were to: (i) determine CTO frequency in a large representative sample of first episode psychosis (FEP) patients; (ii) compare the characteristics of patients with or without CTO before entry, during treatment and at discharge from an early psychosis program. METHODS: Information on 660 patients treated at the Early Psychosis Prevention and Intervention Centre (EPPIC) between 1998 and 2000 was collected from medical files...
December 27, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/28003288/protocol-for-a-multicentre-study-to-assess-feasibility-acceptability-effectiveness-and-direct-costs-of-triumph-treatment-and-recovery-in-psychosis-integrated-care-pathway-for-psychosis
#19
Shanaya Rathod, Christie Garner, Alison Griffiths, Borislav D Dimitrov, Katherine Newman-Taylor, Chris Woodfine, Lars Hansen, Paul Tabraham, Karen Ward, Carolyn Asher, Peter Phiri, Farooq Naeem, Pippa North, Tariq Munshi, David Kingdon
INTRODUCTION: Duration of untreated psychosis (time between the onset of symptoms and start of treatment) is considered the strongest predictor of symptom severity and outcome. Integrated care pathways that prescribe timeframes around access and interventions can potentially improve quality of care. METHODS AND ANALYSIS: A multicentre mixed methods study to assess feasibility, acceptability, effectiveness and analysis of direct costs of an integrated care pathway for psychosis...
December 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27984822/utility-of-risk-status-for-predicting-psychosis-and-related-outcomes-evaluation-of-a-10-year-cohort-of-presenters-to-a-specialised-early-psychosis-community-mental-health-service
#20
Agatha M Conrad, Terry J Lewin, Ketrina A Sly, Ulrich Schall, Sean A Halpin, Mick Hunter, Vaughan J Carr
Psychosis transition rates by those at clinical high risk have been highly variable and few studies have compared service presenters across the full psychosis risk spectrum with respect to medium-term outcomes. A 10-year service cohort was examined (N=1997), comprising all presentations to an early psychosis service for young people experiencing a recent psychotic episode or at increased risk ('Psychological Assistance Service', Newcastle, Australia). Baseline and longitudinal service data (median follow-up =7...
January 2017: Psychiatry Research
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