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https://www.readbyqxmd.com/read/29127185/advances-in-computational-modelling-for-personalised-medicine-after-myocardial-infarction
#1
REVIEW
Kenneth Mangion, Hao Gao, Dirk Husmeier, Xiaoyu Luo, Colin Berry
Myocardial infarction (MI) is a leading cause of premature morbidity and mortality worldwide. Determining which patients will experience heart failure and sudden cardiac death after an acute MI is notoriously difficult for clinicians. The extent of heart damage after an acute MI is informed by cardiac imaging, typically using echocardiography or sometimes, cardiac magnetic resonance (CMR). These scans provide complex data sets that are only partially exploited by clinicians in daily practice, implying potential for improved risk assessment...
November 10, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29125109/impact-of-myocardial-bridge-mural-coronary-artery-on-myocardial-functions
#2
Xin-Bin Zhao, Yu Fu, Jie Li, Meng Sun, He-Liang Zhao
Objective To study the impact of myocardial bridge (MB)-mural coronary artery (MCA) on myocardial functions.Methods Totally 82 patients presenting with chest tightness and chest pain who were diagnosed with the MB in the left anterior descending artery by CT coronary angiography were enrolled as the MB group,in which the thickness and length of MB and the systolic stenosis degree of MCA were measured.In addition,82 healthy subjects,as confirmed by health check-up,were set as the control group.The age,gender,body mass index (BMI),heart rate (HR),smoking history,interventricular septal thickness,left ventricular posterior wall thickness,diameter of left atrium,left ventricular end-diastolic diameter,left ventricular end-systolic diameter,left ventricular ejection fraction,and the cases of E'/A'<1 were compared between MB group and control group...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29122952/organ-level-validation-of-a-cross-bridge-cycling-descriptor-in-a-left-ventricular-finite-element-model-effects-of-ventricular-loading-on-myocardial-strains
#3
Sheikh Mohammad Shavik, Samuel T Wall, Joakim Sundnes, Daniel Burkhoff, Lik Chuan Lee
Although detailed cell-based descriptors of cross-bridge cycling have been applied in finite element (FE) heart models to describe ventricular mechanics, these multiscale models have never been tested rigorously to determine if these descriptors, when scaled up to the organ-level, are able to reproduce well-established organ-level physiological behaviors. To address this void, we here validate a left ventricular (LV) FE model that is driven by a cell-based cross-bridge cycling descriptor against key organ-level heart physiology...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29120879/coronary-perforation-to-left-ventricular-cavity-following-stenting-within-a-myocardial-bridge
#4
Belén Rubio-Alonso, Julio García-Tejada, Carolina Granda-Nistal
No abstract text is available yet for this article.
November 8, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29116137/cardiovascular-consequences-of-myocardial-bridging-a-meta-analysis-and-meta-regression
#5
Sorin Hostiuc, Mugurel Constantin Rusu, Mihaela Hostiuc, Ruxandra Irina Negoi, Ionuț Negoi
Myocardial bridging, a congenital abnormality in which a coronary artery tunnels through the myocardial fibres was usually considered a benign condition. Many studies suggested a potential hemodynamic significance of myocardial bridging and some, usually case reports, implied a possible correlation between it and various cardiovascular pathologies like acute myocardial infarction, ventricular rupture, life-threatening arrhythmias, hypertrophic cardiomyopathy, apical ballooning syndrome or sudden death. The main objective of this article is to evaluate whether myocardial bridging may be associated with significant cardiac effects or if it is strictly a benign anatomical variation...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29079674/myocardial-bridge-bridging-the-differential-diagnosis
#6
Mayur Patel, Brenen Swofford, Edward Distler
A 50-year-old man with a history of vasospastic angina diagnosed 3 months prior presented with recurrent episodes of substernal chest pain. His chest pain was characterised as 'squeezing', lasting 10 min and typically occurred on awakening. Medications included isosorbide, nitroglycerin and ranolazine; however, due to lack of insurance he was unable to obtain these medications. On admission, patient was given a full-dose aspirin and nitroglycerin, which acutely worsened his chest pain. ECG did not reveal ischaemic changes and initial troponin was negative...
October 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29074047/outcomes-of-surgical-intervention-for-anomalous-aortic-origin-of-a-coronary-artery-a-large-contemporary-prospective-cohort-study
#7
Carlos M Mery, Luis E De León, Silvana Molossi, S Kristen Sexson-Tejtel, Hitesh Agrawal, Rajesh Krishnamurthy, Prakash Masand, Athar M Qureshi, E Dean McKenzie, Charles D Fraser
OBJECTIVE: The purpose of this study was to prospectively analyze the outcomes of patients with anomalous aortic origin of a coronary artery undergoing surgical intervention according to a standardized management algorithm. METHODS: All patients aged 2 to 18 years undergoing surgical intervention for anomalous aortic origin of a coronary artery between December 2012 and April 2017 were prospectively included. Patients underwent stress nuclear perfusion imaging, stress cardiac magnetic resonance imaging, and retrospectively electrocardiogram-gated computed tomography angiography preoperatively...
September 14, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29061186/successful-bridge-to-recovery-in-fulminant-myocarditis-using-a-biventricular-assist-device-a-case-report
#8
Yusuke Adachi, Osamu Kinoshita, Masaru Hatano, Yukako Shintani, Noritsugu Naito, Mitsutoshi Kimura, Kan Nawata, Daisuke Nitta, Hisataka Maki, Kazutaka Ueda, Eisuke Amiya, Eiki Takimoto, Issei Komuro, Minoru Ono
BACKGROUND: Fulminant myocarditis is a life-threatening disease, and myocardial damage expands the right ventricle as well as the left ventricle in some cases. There is a mortality rate of over 40% in patients with fulminant myocarditis who need mechanical circulatory support by peripheral venoarterial extracorporeal membrane oxygenation. CASE PRESENTATION: We report a case of a 27-year-old Japanese woman who was successfully bridged to recovery by using a biventricular assist device...
October 24, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29049223/myocardial-ct-perfusion-imaging-for-pre-and-postoperative-evaluation-of-myocardial-ischemia-in-a-patient-with-myocardial-bridging-a-case-report
#9
Jae Woong Lim, Heon Lee, Keun Her, Hyun Woo Park, Kyung Eun Shin
RATIONALE: Although myocardial bridging (MB) is usually considered as benign, initial medical therapy and following surgical treatment in drug-refractory cases has been widely accepted for managing symptomatic MB. Before the patient proceeds to percutaneous or surgical intervention, however, the presence of objective ischemia in the corresponding myocardial territory should be documented. PATIENT CONCERN AND INTERVENTION: We herein report a 43-year-old male complaining of chest pain in whom cardiac CT with myocardial perfusion (cCTP) showed an MB of left anterior descending artery (LAD) with preoperative perfusion defect in corresponding myocardium and normalization of perfusion after supra-arterial myotomy...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29044562/myocardial-bridging-a-meta-analysis-of-prevalence
#10
Sorin Hostiuc, Ionuț Negoi, Mugurel C Rusu, Mihaela Hostiuc
The main objective of this article was to analyze prevalence data about myocardial bridging (MB) in published studies. To this purpose, we performed a meta-analysis of studies published in English literature that contained data about the prevalence of MB and its anatomical characteristics. The overall prevalence was 19% (CI: 17-21%); autopsy studies revealed an overall prevalence of 42% (CI: 30-55%), CT studies 22% (CI: 18-25%), and coronary angiography 6% (CI: 5-8%). Most bridges were located on the left anterior descending artery (82% overall, 63% on autopsy studies), had a mean thickness of 2...
October 16, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29041882/-specific-characteristics-of-coronary-atherosclerosis
#11
S V Pykhteev, A K Lashevich, P A Bogdan, A S Belash
In this review, we present modern aspects of etiology and pathogenesis of atherosclerosis. We describe the roles played by inflammatory cells, components of cellular response in allergic reactions, disturbances of carbohydrate metabolism, cellular aging, and infection at various stages of formation of atherosclerotic plaques. Special attention is given to the specific characteristics of atherosclerosis and calcification of coronary arteries. We show the influence of age and gender on the disease progression...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29030424/stable-coronary-syndromes-pathophysiology-diagnostic-advances-and-therapeutic-need
#12
REVIEW
Thomas J Ford, David Corcoran, Colin Berry
The diagnostic management of patients with angina pectoris typically centres on the detection of obstructive epicardial CAD, which aligns with evidence-based treatment options that include medical therapy and myocardial revascularisation. This clinical paradigm fails to account for the considerable proportion (approximately one-third) of patients with angina in whom obstructive CAD is excluded. This common scenario presents a diagnostic conundrum whereby angina occurs but there is no obstructive CAD (ischaemia and no obstructive coronary artery disease-INOCA)...
October 13, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29030372/dose-dependent-effects-of-the-myosin-activator-omecamtiv-mecarbil-on-cross-bridge-behavior-and-force-generation-in-failing-human-myocardium
#13
Ranganath Mamidi, Jiayang Li, Kenneth S Gresham, Sujeet Verma, Chang Yoon Doh, Amy Li, Sean Lal, Cristobal G Dos Remedios, Julian E Stelzer
BACKGROUND: Omecamtiv mecarbil (OM) enhances systolic function in vivo by directly binding the myosin cross-bridges (XBs) in the sarcomere. However, the mechanistic details governing OM-induced modulation of XB behavior in failing human myocardium are unclear. METHODS AND RESULTS: The effects of OM on steady state and dynamic XB behavior were measured in chemically skinned myocardial preparations isolated from human donor and heart failure (HF) left ventricle. HF myocardium exhibited impaired contractile function as evidenced by reduced maximal force, magnitude of XB recruitment (Pdf), and a slowed rate of XB detachment (krel) at submaximal Ca(2+) activations...
October 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29022423/combination-antiplatelet-treatment-in-coronary-artery-disease-patients-a-necessary-evil-or-an-overzealous-practice
#14
Dimitrios Alexopoulos, Konstantinos Katogiannis, Danai Sfantou, John Lekakis
In seeking to improve care in coronary artery disease patients, further platelet inhibition has been occasionally applied beyond that provided by aspirin and a P2Y12 receptor antagonist. This review aims to offer insights about the rationale, the efficacy and safety of combination antiplatelet therapy, involving three or more agents. Overall, the use of glycoprotein (GP) IIb/IIIa inhibitors did not significantly modify the treatment effect of different antiplatelet strategies, including double vs standard clopidogrel, prasugrel vs clopidogrel, ticagrelor vs clopidogrel, cangrelor vs clopidogrel, and vorapaxar vs placebo...
October 12, 2017: Platelets
https://www.readbyqxmd.com/read/29016382/myocardial-bridging-in-left-main-coronary-artery
#15
Rong Xu, Yong He, Lin-Jun Xie, Meng-Xi Yang, Zhi-Gang Yang, Ying-Kun Guo
No abstract text is available yet for this article.
October 9, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28993001/absence-of-adventitial-vasa-vasorum-formation-at-the-coronary-segment-with-myocardial-bridge-an-optical-coherence-tomography-study
#16
Kensuke Nishimiya, Yasuharu Matsumoto, Hongxin Wang, Zhonglie Piao, Kazuma Ohyama, Hironori Uzuka, Kiyotaka Hao, Ryuji Tsuburaya, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa
BACKGROUND: Myocardial bridge (MB) is a myocardial bundle through which coronary segment tunnels and could compress coronary arteries causing myocardial ischemia. However, the characteristic structural findings of MB remain to be fully elucidated. Recently, we demonstrated that optical coherence tomography (OCT) enables us to visualize adventitial vasa vasorum (VV) formation in humans. In this study, we examined adventitial VV formation at the coronary segment with MB in humans using OCT...
October 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28986404/predictors-of-successful-chronic-total-occlusion-percutaneous-coronary-interventions-a-systematic-review-and-meta-analysis
#17
Nelson Wang, Jordan Fulcher, Nishan Abeysuriya, Mark Adams, Sean Lal
OBJECTIVE: The aim of this study was to identify positive and negative predictors of technical and clinical success for percutaneous coronary intervention (PCI) of chronic total occlusions (CTO). METHODS: We conducted a systematic review and meta-analysis of studies published between 2000 and 2016 analysing rates of CTO PCI success with respect to demographic and angiographic characteristics. Crude ORs and 95% CIs for each predictor were calculated using a random effects model...
October 6, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28950296/a-modified-explant-technique-of-heartware-ventricular-assist-device-for-bridge-to-recovery
#18
Yasuhiro Shudo, Chun W Choi, Y Joseph Woo, Richard-Tien V Ha
The HeartWare left ventricular assist device is a miniaturized, continuous centrifugal-flow pump. The implantation technique is well described and relatively standardized across different institutions. However, there still exists a technical concern about handling the inflow cannula at the time of device explant. Specifically, the removal of the sewing ring and plicating the apical defect en masse may distort the geometry of the left ventricle and impart myocardial dysfunction. Additionally, a prefabricated repair mechanism by the manufacturer is not readily available in all countries (i...
July 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28921787/myocardial-bridging-is-associated-with-exercise-induced-ventricular-arrhythmia-and-increases-in-qt-dispersion
#19
Makiko Nishikii-Tachibana, Vedant S Pargaonkar, Ingela Schnittger, Francois Haddad, Ian S Rogers, Jennifer A Tremmel, Paul J Wang
BACKGROUND: A myocardial bridge (MB) has been associated with ventricular arrhythmia and sudden death during exercise. QT dispersion (QTd) is a measure of abnormal repolarization and may predict ventricular arrhythmia. We investigated the frequency of ventricular arrhythmias during exercise and the QTd at rest and after exercise, in patients with an MB compared to a normal cohort. METHODS: We studied the rest and stress ECG tracings of patients with an MB suspected by focal septal buckling on exercise echocardiography (EE) (Echo-MB group, N = 510), those with an MB confirmed by another examination (MB group, N = 110), and healthy controls (Control group, N = 198)...
September 18, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28878878/successful-treatment-of-aortic-root-dissection-complicated-with-extensive-myocardial-infarction-using-the-total-artificial-heart
#20
Tamer Attia, Michael Robich, A Michael Lincoff, Mehdi H Shishehbor, Lars Svensson, Nicholas G Smedira
Acute Type A aortic dissection is a surgical emergency. Urgent repair is indicated to avoid complications such as acute aortic insufficiency, coronary ischemia and aortic rupture with cardiac tamponade. This report details the management of a patient with acute Type A aortic dissection complicated by an extensive anterolateral myocardial infarction and cardiogenic shock who was successfully bridged to transplantation with a total artificial heart.
August 2017: Journal of Surgical Case Reports
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