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myocardial bridge

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https://www.readbyqxmd.com/read/28921787/myocardial-bridging-is-associated-with-exercise-induced-ventricular-arrhythmia-and-increases-in-qt-dispersion
#1
Makiko Nishikii-Tachibana, Vedant S Pargaonkar, Ingela Schnittger, Francois Haddad, Ian S Rogers, Jennifer A Tremmel, Paul J Wang
BACKGROUND: A myocardial bridge (MB) has been associated with ventricular arrhythmia and sudden death during exercise. QT dispersion (QTd) is a measure of abnormal repolarization and may predict ventricular arrhythmia. We investigated the frequency of ventricular arrhythmias during exercise and the QTd at rest and after exercise, in patients with an MB compared to a normal cohort. METHODS: We studied the rest and stress ECG tracings of patients with an MB suspected by focal septal buckling on exercise echocardiography (EE) (Echo-MB group, N = 510), those with an MB confirmed by another examination (MB group, N = 110), and healthy controls (Control group, N = 198)...
September 18, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28878878/successful-treatment-of-aortic-root-dissection-complicated-with-extensive-myocardial-infarction-using-the-total-artificial-heart
#2
Tamer Attia, Michael Robich, A Michael Lincoff, Mehdi H Shishehbor, Lars Svensson, Nicholas G Smedira
Acute Type A aortic dissection is a surgical emergency. Urgent repair is indicated to avoid complications such as acute aortic insufficiency, coronary ischemia and aortic rupture with cardiac tamponade. This report details the management of a patient with acute Type A aortic dissection complicated by an extensive anterolateral myocardial infarction and cardiogenic shock who was successfully bridged to transplantation with a total artificial heart.
August 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28875457/patient-satisfaction-with-care-after-coronary-revascularization
#3
Danielle L Mosby, Matthew J Manierre, Steve S Martin, Paul Kolm, A Sami Abuzaid, Claudine T Jurkovitz, Daniel J Elliott, William S Weintraub
OBJECTIVE: Bridging the Divides (Bridges), a Centers for Medicare and Medicaid Services-funded program, developed a post-hospitalization care management infrastructure integrating information technology-enabled informatics with patient care for ischemic heart disease patients. The objective of this study was to assess patient satisfaction with the Bridges program and determine the patient characteristics associated with higher satisfaction. METHODS: All adult English-speaking patients who underwent a percutaneous coronary intervention, coronary artery bypass grafting, or catheterization plus acute myocardial infarction and agreed to participate in the Bridges program were eligible...
September 5, 2017: Patient
https://www.readbyqxmd.com/read/28838524/aborted-sudden-cardiac-death-after-unroofing-of-anomalous-left-coronary-artery
#4
Hitesh Agrawal, S Kristen Sexson-Tejtel, Athar M Qureshi, Mahboob Alam, Prakash Masand, Charles D Fraser, Silvana Molossi, Carlos M Mery
We describe a patient with anomalous left coronary artery with a short intramural course and a previously unrecognized myocardial bridge who presented with a recurrent episode of aborted sudden cardiac death. Intravascular ultrasound and fractional flow reserve showed significant compression at the left coronary artery ostium by the intercoronary pillar and at the myocardial bridge. Intravascular ultrasound and fractional flow reserve were normal after coronary translocation and unroofing of the myocardial bridge...
September 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28834785/what-is-the-optimal-treatment-for-symptomatic-patients-with-isolated-coronary-myocardial-bridge-a-systematic-review-and-pooled-analysis
#5
Enrico Cerrato, Umberto Barbero, Fabrizio D'Ascenzo, Salma Taha, Giuseppe Biondi-Zoccai, Pierluigi Omedè, Matteo Bianco, Mauro Echavarria-Pinto, Javier Escaned, Fiorenzo Gaita, Ferdinando Varbella
BACKGROUND: Myocardial bridging is a common coronary anomaly, with few severe adverse events but a relevant symptom burden. Myocardial bridging treatment, however, remains uncertain because of the lack of randomized trials. MATERIAL: MEDLINE/PubMed was systematically screened for studies reporting on isolated myocardial bridging diagnosed at coronary angiography or with coronary computed tomography in patients admitted for suspected angina or with an acute coronary syndrome...
October 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28810808/advances-and-challenges-in-cardiovascular-gene-therapy
#6
Seppo Ylä-Herttuala, Johanna Lähteenvuo
25 years of gene therapy have not yet yielded standard therapeutic solutions for clinical use in cardiovascular medicine, but several therapeutic targets have been identified and foundations for future therapies have been set. The safety of viral gene therapy has been established with a wide variety of vectors and transgenes. Adenoviruses and adeno-associated viruses have established their role as vectors of choice for many cardiovascular applications and appropriate viral doses have been established for several tissues and applications...
August 16, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28776069/porcine-arteriogenesis-based-on-vasa-vasorum-in-a-novel-semi-acute-occlusion-model-using-high-resolution-imaging
#7
Jonathan M Harnoss, Florian Krackhardt, Zully Ritter, Susanne Granzow, Dieter Felsenberg, Konrad Neumann, Lilach O Lerman, Fabian Riediger, Philipp Hillmeister, Peter Bramlage, Ivo R Buschmann
Bridging collaterals (BC) develop in several chronic total artery occlusion diseases, and can prevent extensive myocardial necrosis. Yet, their origin, growth process, and histo-morphology are still unclear. Since vasa vasorum (VV) may take part in collateralization, we hypothesized that VV are the basis for BCs. To comprehensively investigate this arteriogenesis process, we used high-resolution imaging, including corrosion casts, post-mortem angiography with stereoscopy, micro-CT, and immunohistology, in combination with a novel semi-acute vessel occlusion model...
August 3, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28771609/deletion-of-batf3-dependent-antigen-presenting-cells-does-not-affect-atherosclerotic-lesion-formation-in-mice
#8
Jesus Gil-Pulido, Clement Cochain, Malte A Lippert, Nicole Schneider, Elke Butt, Núria Amézaga, Alma Zernecke
Atherosclerosis is the main underlying cause for cardiovascular events such as myocardial infarction and stroke and its development might be influenced by immune cells. Dendritic cells (DCs) bridge innate and adaptive immune responses by presenting antigens to T cells and releasing a variety of cytokines. Several subsets of DCs can be discriminated that engage specific transcriptional pathways for their development. Basic leucine zipper transcription factor ATF-like 3 (Batf3) is required for the development of classical CD8α+ and CD103+ DCs...
2017: PloS One
https://www.readbyqxmd.com/read/28770255/massive-accumulation-of-myofibroblasts-in%C3%A2-the-critical-isthmus-is-associated-with%C3%A2-ventricular-tachycardia-inducibility-in%C3%A2-post-infarct-swine-heart
#9
Tarvinder S Dhanjal, Nicolas Lellouche, Christopher J von Ruhland, Guillaume Abehsira, David H Edwards, Jean-Luc Dubois-Randé, Konstantinos Moschonas, Emmanuel Teiger, Alan J Williams, Christopher H George
OBJECTIVES: In this study the authors determined the extent of cellular infiltration and dispersion, and regional vascularization in electrophysiologically (EP) defined zones in post-myocardial infarction (MI) swine ventricle. BACKGROUND: The critical isthmus (CI) in post-MI re-entrant ventricular tachycardia (VT) is a target for catheter ablation. In vitro evidence suggests that myofibroblasts (MFB) within the scar border zone (BZ) may increase the susceptibility to slow conduction and VT, but whether this occurs in vivo remains unproven...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28759083/a-rare-cause-of-early-repolarisation-in-an-adolescent-boy-with-chest-pain-myocardial-bridging
#10
Murat Deveci, Kadir Babaoğlu, Özlem Kayabey
Early repolarisation is a common electrocardiographic (ECG) finding characterised by J-point and ST segment elevation ≥ 0.1 mV in two or more adjacent leads. The ECG pattern of early repolarisation is relatively common in asymptomatic subjects. Early repolarisation pattern may be seen in secondary conditions such as hypothermia, autonomic nervous system disturbances, cocaine abuse, hypercalcaemia and myocardial ischaemia. We present a case of an adolescent boy with chest pain and concurrent ST-segment elevation...
May 23, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28746082/heartware-ventricular-assist-device-as-a-bridge-to-transplant-in-a-small-boy-with-complicated-kawasaki-disease
#11
Christopher E Mascio, Dhananjay P Malankar, Jonathan J Rome
We report a case of HeartWare ventricular assist device (HVAD) implant as a Bridge-to-Transplant in the smallest and the youngest known patient, a 32-month-old boy (body surface area of 0.66 m2) with known Kawasaki disease and giant coronary artery aneurysms. The disease course was complicated by coronary thromboembolism resulting in acute myocardial infarction, ventricular fibrillation, and cardiac arrest. After short-term support with extracorporeal membrane oxygenation for 7 days and long-term support with an HVAD for 5 months, he underwent heart transplantation and is doing well 2 months after the transplant...
July 25, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28740631/increased-risk-of-coronary-perforation-during-percutaneous-intervention-of-myocardial-bridge-what-histopathology-says
#12
Somayeh Pourhoseini, Mohammad Bakhtiari, Abdolreza Babaee, Mohammad Ali Ostovan, Seyed Hassan Eftekhar-Vaghefi, Nikan Ostovan, Pooyan Dehghani
Introduction: Myocardial bridge (MB) is a segment of a major epicardial coronary artery that goes intramurally under a bridge of overlying myocardium. Complications have been reported during or after stent implantation particularly coronary perforation. The aim of this study was to determine histological differences between proximal left anterior descending artery (LAD) and the tunneled segment that may have a possible role in increased risk of coronary artery perforation during percutaneous coronary intervention...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28712560/relation-between-severity-of-myocardial-bridge-and-vasospasm
#13
Yuichi Saito, Hideki Kitahara, Toshihiro Shoji, Satoshi Tokimasa, Takashi Nakayama, Kazumasa Sugimoto, Yoshihide Fujimoto, Yoshio Kobayashi
BACKGROUND: Myocardial bridge (MB) has been reported to induce cardiac complications including coronary vasospasm. Although MB has some anatomical and morphological variations, the association of these variations with vasospasm is unclear. The aim of this study was to investigate the relation between morphological severity of MB and vasospasm induced by acetylcholine (ACh) provocation test. METHODS: A total of 392 patients without coronary stent in the left anterior descending artery (LAD) undergoing intracoronary ACh provocation test were included...
July 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28699980/myocardial-bridge-and-angiotomography-of-the-coronary-arteries-perfusion-under-pharmacological-stress
#14
Wilter Dos Santos Ker, Daniel Gama Neves, Alair Sarmet A A Damas, Cláudio Tinoco Mesquita, Marcelo Souto Nacif
No abstract text is available yet for this article.
June 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28696881/persistent-left-superior-vena-cava-incidence-and-management-in-patients-undergoing-repair-of-partial-anomalous-pulmonary-venous-connection
#15
Nicholas S Clarke, Raghav A Murthy, Kristine J Guleserian
INTRODUCTION: A association between partial anomalous pulmonary venous connection (PAPVC) and systemic venous anomalies has been described in the literature, but the true incidence is yet to be elucidated. At our institution, we sought to find the incidence of a persistent left superior vena cava (PLSVC) in patients undergoing an operation for PAPVC. METHODS: A retrospective review of all pediatric and adult patients with PAPVC who underwent surgical repair from February 2006 to February 2016...
July 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28690285/myocardial-bridges-on-coronary-computed-tomography-angiography%C3%A3-correlation-with-intravascular-ultrasound-and-fractional-flow-reserve
#16
Signe Helene Forsdahl, Ian S Rogers, Ingela Schnittger, Shigemitsu Tanaka, Takumi Kimura, Vedant S Pargaonkar, Frandics P Chan, Dominik Fleischmann, Jennifer A Tremmel, Hans-Christoph Becker
BACKGROUND: Myocardial bridges (MB) are commonly seen on coronary CT angiography (CCTA) in asymptomatic individuals, but in patients with recurrent typical angina symptoms, yet no obstructive coronary artery disease (CAD), evaluation of their potential hemodynamic significance is clinically relevant. The aim of this study was to compare CCTA to invasive coronary angiography (ICA), including intravascular ultrasound (IVUS), to confirm MB morphology and estimate their functional significance in symptomatic patients...
July 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28688833/balloon-aortic-valvuloplasty-in-the-transcatheter-valve-era-single-centre-indications-and-early-safety-data-in-a-high-risk-population
#17
Thomas J Ford, Katherine Nguyen, Joseph Brassil, Virag Kushwaha, Daniel Friedman, Roger Allan, Mark Pitney, Nigel Jepson
BACKGROUND: The introduction of transcatheter aortic valve implantation (TAVI) has generated a renewed interest in the techniques available to treat high-risk patients with severe aortic stenosis (AS). We report our single centre experience with balloon aortic valvuloplasty (BAV) focussing on indications, procedural success and 30-day outcomes. METHODS: We retrospectively reviewed all patients that underwent BAV procedures at our institution between August 2012 and August 2014...
June 2, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28675696/myocardial-bridges-overview-of-diagnosis-and-management
#18
Ian S Rogers, Jennifer A Tremmel, Ingela Schnittger
A myocardial bridge is a segment of a coronary artery that travels into the myocardium instead of the normal epicardial course. Although it is general perception that myocardial bridges are normal variants, patients with myocardial bridges can present with symptoms, such as exertional chest pain, that cannot be explained by a secondary etiology. Such patients may benefit from individualized medical/surgical therapy. This article describes the prevalence, clinical presentation, classification, evaluation, and management of children and adults with symptomatic myocardial bridges...
July 3, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28670160/assessment-of-myocardial-bridge-by-cardiac-ct-intracoronary-transluminal-attenuation-gradient-derived-from-diastolic-phase-predicts-systolic-compression
#19
Mengmeng Yu, Yang Zhang, Yuehua Li, Minghua Li, Wenbin Li, Jiayin Zhang
OBJECTIVE: To study the predictive value of transluminal attenuation gradient (TAG) derived from diastolic phase of coronary computed tomography angiography (CCTA) for identifying systolic compression of myocardial bridge (MB). MATERIALS AND METHODS: Consecutive patients diagnosed with MB based on CCTA findings and without obstructive coronary artery disease were retrospectively enrolled. In total, 143 patients with 144 MBs were included in the study. Patients were classified into three groups: without systolic compression, with systolic compression < 50%, and with systolic compression ≥ 50%...
July 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28666802/a-novel-modified-physiologically-relevant-model-for-cardiac-angiogenesis
#20
Hao Zhang, Jiajun Pan, Fan Qiu, Tengteng Wei, Zhimin Li, Xia Jiang, Wei Zhuang, Zhiwei Liu, Zhongming Zhang, Hongyan Dong
Angiogenesis assays are important tools for studying both the mechanisms of cardiac angiogenesis and the potential development of therapeutic strategies to ischemic heart diseases. Currently, various assays have been used to quantitate cardiac tubule formation, yet no consensus has been reached regarding a suitable assay for evaluating the efficacy of angiogenic stimulants or inhibitors. Most in vivo angiogenesis assays are complex and difficult to interpret, whereas traditional in vitro angiogenesis models measure only one aspect of this process...
June 28, 2017: Microvascular Research
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