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https://www.readbyqxmd.com/read/29332185/handedness-and-the-risk-of-glioma
#1
Briana Miller, Noah C Peeri, Louis Burt Nabors, Jordan H Creed, Zachary J Thompson, Carrie M Rozmeski, Renato V LaRocca, Sajeel Chowdhary, Jeffrey J Olson, Reid C Thompson, Kathleen M Egan
Gliomas are the most common type of malignant primary brain tumor and few risk factors have been linked to their development. Handedness has been associated with several pathologic neurological conditions such as schizophrenia, autism, and epilepsy, but few studies have evaluated a connection between handedness and risk of glioma. In this study, we examined the relationship between handedness and glioma risk in a large case-control study (1849 glioma cases and 1354 healthy controls) and a prospective cohort study (326,475 subjects with 375 incident gliomas)...
January 13, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29330383/development-of-a-pet-radioligand-for-potassium-channels-to-image-cns-demyelination
#2
Pedro Brugarolas, Jorge E Sánchez-Rodríguez, Hsiu-Ming Tsai, Falguni Basuli, Shih-Hsun Cheng, Xiang Zhang, Andrew V Caprariello, Jerome J Lacroix, Richard Freifelder, Dhanabalan Murali, Onofre DeJesus, Robert H Miller, Rolf E Swenson, Chin-Tu Chen, Peter Herscovitch, Daniel S Reich, Francisco Bezanilla, Brian Popko
Central nervous system (CNS) demyelination represents the pathological hallmark of multiple sclerosis (MS) and contributes to other neurological conditions. Quantitative and specific imaging of demyelination would thus provide critical clinical insight. Here, we investigated the possibility of targeting axonal potassium channels to image demyelination by positron emission tomography (PET). These channels, which normally reside beneath the myelin sheath, become exposed upon demyelination and are the target of the MS drug, 4-aminopyridine (4-AP)...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320877/-i-m-still-me-i-m-still-here-understanding-the-person-s-sense-of-self-in-the-provision-of-self-management-support-for-people-with-progressive-neurological-long-term-conditions
#3
Stefan Tino Kulnik, Lucinda Hollinshead, Fiona Jones
PURPOSE: There is increasing interest in tailoring self-management support, but little detail is available on the relevance and impact of such approaches for people with progressive neurological conditions. The aim of this study was to draw on individuals' experiences to inform the practice of self-management support for these groups. METHOD: Community rehabilitation service users were purposively recruited and took part in in-depth qualitative interviews. Interviews were audio-recorded and transcribed...
January 11, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29318935/psychosocial-features-of-neurofibromatosis-type-1-in-children-and-adolescents
#4
Vincent Domon-Archambault, Louise Gagnon, Amélie Benoît, Sébastien Perreault
Neurofibromatosis type 1 (NF1) is a common neurologic condition associated with a wide variety of developmental deficits that have an important impact on children and adolescents. OBJECTIVE: This article aims to document the psychosocial features of NF1 and to report the interventions described to address the needs of pediatric patients with NF1. METHODS: A literature review was conducted concerning the social life, mental health, and quality of life (QOL) of children and adolescents with NF1 as well as the psychosocial interventions addressed to this population...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29315412/automated-pupillometry-and-detection-of-clinical-transtentorial-brain-herniation-a-case-series
#5
Alexander Papangelou, Elizabeth K Zink, Wan-Tsu W Chang, Anthony Frattalone, Daniel Gergen, Allan Gottschalk, Romergryko G Geocadin
Introduction: Transtentorial herniation (TTH) is a life-threatening neurologic condition that typically results from expansion of supratentorial mass lesions. A change in bedside pupillary examination is central to the clinical diagnosis of TTH. Materials and Methods: To quantify the changes in the pupillary examination that precede and accompany TTH and its treatment, we evaluated 12 episodes of herniation in three patients with supratentorial mass lesions using automated pupillometry (NeurOptics, Inc...
January 5, 2018: Military Medicine
https://www.readbyqxmd.com/read/29315107/multiple-sclerosis-and-exercise-a-literature-review
#6
Eric R Reynolds, Andrew D Ashbaugh, Brandon J Hockenberry, Christopher A McGrew
Multiple sclerosis (MS) is the most common autoimmune disabling neurological conditions of young adults and affects more than 2.3 million people worldwide. Given the high likelihood for disability and decreased neurological function, there have been concerns about the role of exercise in MS patients with a fear of increased injury. This article looks at recent articles evaluating the role of exercise in MS and can hopefully be used by patients, caregivers, and health care providers to guide decision making about the role of exercise in patients with MS...
January 2018: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/29314763/integrating-exome-sequencing-into-a-diagnostic-pathway-for-epileptic-encephalopathy-evidence-of-clinical-utility-and-cost-effectiveness
#7
Elizabeth E Palmer, Deborah Schofield, Rupendra Shrestha, Tejaswi Kandula, Rebecca Macintosh, John A Lawson, Ian Andrews, Hugo Sampaio, Alexandra M Johnson, Michelle A Farrar, Michael Cardamone, David Mowat, George Elakis, William Lo, Ying Zhu, Kevin Ying, Paula Morris, Jiang Tao, Kerith-Rae Dias, Michael Buckley, Marcel E Dinger, Mark J Cowley, Tony Roscioli, Edwin P Kirk, Ann Bye, Rani K Sachdev
BACKGROUND: Epileptic encephalopathies are a devastating group of neurological conditions in which etiological diagnosis can alter management and clinical outcome. Exome sequencing and gene panel testing can improve diagnostic yield but there is no cost-effectiveness analysis of their use or consensus on how to best integrate these tests into clinical diagnostic pathways. METHODS: We conducted a retrospective cost-effectiveness study comparing trio exome sequencing with a standard diagnostic approach, for a well-phenotyped cohort of 32 patients with epileptic encephalopathy, who remained undiagnosed after "first-tier" testing...
January 4, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29314172/shifting-mindsets-a-realist-synthesis-of-evidence-from-self-management-support-training
#8
REVIEW
Freya Davies, Fiona Wood, Alison Bullock, Carolyn Wallace, Adrian Edwards
CONTEXT: Accompanying the growing expectation of patient self-management is the need to ensure health care professionals (HCPs) have the required attitudes and skills to provide effective self-management support (SMS). Results from existing training interventions for HCPs in SMS have been mixed and the evidence base is weaker for certain settings, including supporting people with progressive neurological conditions (PNCs). We set out to understand how training operates, and to identify barriers and facilitators to training designed to support shifts in attitudes amongst HCPs...
January 4, 2018: Medical Education
https://www.readbyqxmd.com/read/29305644/mal-de-debarquement-syndrome-a-survey-on-subtypes-misdiagnoses-onset-and-associated-psychological-features
#9
V Mucci, J M Canceri, R Brown, M Dai, S Yakushin, S Watson, A Van Ombergen, V Topsakal, P H Van de Heyning, F L Wuyts, C J Browne
INTRODUCTION: Mal de Debarquement Syndrome (MdDS) is a neurological condition typically characterized by a sensation of motion, that persists longer than a month following exposure to passive motion (e.g., cruise, flight, etc.). The most common form of MdDS is motion triggered (MT). However, recently it has been acknowledged that some patients develop typical MdDS symptoms without an apparent motion trigger. These cases are identified here as spontaneous or other onset (SO) MdDS. This study aimed to address similarities and differences between the MdDS subtypes...
January 5, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29305273/adult-onset-hemorrhagic-quasi-moyamoya-disease-with-unilateral-steno-occlusive-lesion-in-a-patient-with-neurofibromatosis-type-1
#10
Yusuke S Hori, Yuki Ebisudani, Mizuho Aoi, Toru Fukuhara
BACKGROUND: Quasi-moyamoya disease is a condition that occurs in association with a specific underlying condition or disease such as atherosclerotic disease or neurofibromatosis type 1 (NF1). Pediatric cases are frequently reported, and an ischemic and bilateral presentation is more common than a hemorrhagic and unilateral presentation. CLINICAL PRESENTATION: A 39-year-old woman previously diagnosed with NF1 presented to our department with nausea and left hemiparesis...
January 2, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29300812/naturalistic-assessment-using-a-simulated-environment-cognitive-correlates-and-relationship-to-functional-status-in-individuals-with-neurologic-conditions
#11
Kayela Robertson, Maureen Schmitter-Edgecombe, Douglas Weeks, Jane Pimentel
Objective: Research has shown that neurologic conditions, such as traumatic brain injury and multiple sclerosis, result in a number of cognitive and functional deficits. However, little is known about the relationship between various cognitive domains and ability to perform everyday activities. The Community Shopping Task (CST), a naturalistic assessment task conducted in a simulated environment, was used to examine functional abilities and cognitive correlates of everyday functioning in individuals with neurologic conditions...
December 28, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29300166/a-systematic-review-of-zika-virus-hurdles-toward-vaccine-development-and-the-way-forward
#12
Azizul Haque, Faruk Berat Akçeşme, Anudeep B Pant
The Zika virus (ZIKV) epidemic has recently emerged as public health threat due to its teratogenic nature and association with the serious neurological condition Guillain-Barré syndrome (GBS). To date, no approved antiviral therapeutics or vaccines are available to confront ZIKV. In order to develop effective anti-ZIKV vaccines, improved animal models and a better understanding of immunological correlates of protection against ZIKV are required. In this paper, we discuss the recent progress in developing vaccines against ZIKV and the hurdles to overcome in making efficacious anti-Zika vaccines...
January 4, 2018: Antiviral Therapy
https://www.readbyqxmd.com/read/29299869/combination-therapy-with-low-dose-ivig-and-a-c1-esterase-inhibitor-ameliorates-brain-damage-and-functional-deficits-in-experimental-ischemic-stroke
#13
Xinzhi Chen, Thiruma V Arumugam, Yi-Lin Cheng, Jong-Hwan Lee, Srinivasulu Chigurupati, Mark P Mattson, Milan Basta
Acute ischemic stroke causes a high rate of deaths and permanent neurological deficits in survivors. Current interventional treatment, in the form of enzymatic thrombolysis, benefits only a small percentage of patients. Brain ischemia triggers mobilization of innate immunity, specifically the complement system and Toll-like receptors (TLRs), ultimately leading to an exaggerated inflammatory response. Here we demonstrate that intravenous immunoglobulin (IVIG), a scavenger of potentially harmful complement fragments, and C1-esterase inhibitor (C1-INH), an inhibitor of complement activation, exert a beneficial effect on the outcome of experimental brain ischemia (I) and reperfusion (R) injury induced by transient occlusion of middle cerebral artery in mice...
January 3, 2018: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29297656/introduction-to-pseudobulbar-affect-setting-the-stage-for-recognition-and-familiarity-with-this-challenging-disorder
#14
Tammie Lee Demler
Pseudobulbar affect (PBA), despite its prevalence and distinctive symptoms, is widely underrecognized and undertreated. It is characterized by uncontrollable laughing or crying that can occur in an exaggerated manner or inappropriately to a given situation or stimuli. PBA is thought to center around preexisting neurological conditions, which include Parkinson disease, multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer disease, traumatic brain injury, and stroke. The PBA Registry Series trial was created to measure the prevalence of PBA among patients with these underlying neurological conditions...
December 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29296901/low-fetal-hemoglobin-percentage-is-associated-with-silent-brain-lesions-in-adults-with-homozygous-sickle-cell-disease
#15
David Calvet, Titien Tuilier, Nicolas Mélé, Guillaume Turc, Anoosha Habibi, Nassim Ait Abdallah, Loubna Majhadi, François Hemery, Myriam Edjlali, Frédéric Galacteros, Pablo Bartolucci
Silent white matter changes (WMCs) on brain imaging are common in individuals with sickle cell disease (SCD) and are associated with cognitive deficits in children. We investigated the factors predictive of WMCs in adults with homozygous SCD and no history of neurological conditions. Patients were recruited from a cohort of adults with homozygous SCD followed up at an adult sickle cell referral center for which steady-state measurements of biological parameters and magnetic resonance imaging scans of the brain were available...
December 12, 2017: Blood Advances
https://www.readbyqxmd.com/read/29285091/treatment-of-acute-intermittent-porphyria-during-pregnancy-and-posterior-reversible-encephalopathy-syndrome-after-delivery-a-case-report
#16
Jian Zhang, Yiting Hu, Jimin Zheng, Juncha Gao, Hongtao Hou, Na Liu, Yuzhen Wang
Acute intermittent porphyria (AIP) is a rare inherited disorder of heme metabolism. It has the ability to trigger posterior reversible encephalopathy syndrome (PRES), a rare acute neurologic condition that is characterized by acute neurological symptoms. Pregnancy may induce AIP attacks. The present report describes the case of a pregnant woman with AIP. The patient was treated with heme-arginate during pregnancy and successfully delivered a healthy baby. Following delivery, the patient presented with PRES and experienced generalized seizures...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29283018/a-practical-clinical-kinematic-model-for-the-upper-limbs
#17
Jonathan J Noble, Nicola Rd Fry, Carly R Bingham, Rebecca H East, Adam P Shortland
A novel clinically practical upper limb model is introduced that has been developed through clinical use in children and adults with neurological conditions to guide surgery to the elbow and wrist. This model has a minimal marker set, minimal virtual markers, and no functional joint centres to minimise the demands on the patient and duration of data collection. The model calculates forearm supination independently from the humerus segment, eliminating any errors introduced by poor modelling of the shoulder joint centre...
December 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29282348/-a-case-of-cowden-syndrome-associated-with-lhermitte-duclos-disease
#18
Hidefumi Suzuki, Kyoko Hosokawa, Michio Ono, Yasuhiro Kojima, Masutaro Kanda, Hiroshi Shibasaki
A 24-year-old woman slowly developed mild unsteadiness of gait. Neurological examination revealed mild dysmetria of the left upper and lower limbs. Standing and gait were unsteady, and tandem gait was impossible. Cranial magnetic resonance imaging (MRI) showed an enlarged left cerebellar hemisphere with striated lines, a characteristic finding of Lhermitte-Duclos disease. She also had papules on the forehead, goiter, lactating adenoma, glycogenic acanthosis in the esophagus, café-au-lait spot, and hemangioma and keratosis on the dorsum of foot...
December 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29280070/safety-of-human-papillomavirus-vaccines-an-updated-review
#19
REVIEW
Anastasia Phillips, Cyra Patel, Alexis Pillsbury, Julia Brotherton, Kristine Macartney
Human papillomavirus (HPV) vaccines are now included in immunisation programmes in 71 countries. Unfortunately, uptake has been impacted in some countries by reduced confidence in the safety of the HPV vaccine. In 2013, we published an extensive review demonstrating a reassuring safety profile for bivalent (2vHPV) and quadrivalent (4vHPV) vaccines. A nonavalent (9vHPV) vaccine is now available and HPV immunisation programmes have been extended to males in 11 countries. The aim of this updated narrative review was to examine the evidence on HPV vaccine safety, focusing on the 9vHPV vaccine, special populations and adverse events of special interest (AESI)...
December 26, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29278747/gaba-containing-liposomes-neuroscience-applications-and-translational-perspectives-for-targeting-neurological-diseases
#20
REVIEW
Marco Antônio Peliky Fontes, Gisele Cristiane Vaz, Thais Zielke Dias Cardoso, Mariana Flávia de Oliveira, Maria José Campagnole-Santos, Robson Augusto Souza Dos Santos, Neeru M Sharma, Kaushik P Patel, Frédéric Frézard
There are multiple challenges for neuropharmacology in the future. Undoubtedly, one of the greatest challenges is the development of strategies for pharmacological targeting of specific brain regions for treatment of diseases. GABA is the main inhibitory neurotransmitter in the central nervous system, and dysfunction of GABAergic mechanisms is associated with different neurological conditions. Liposomes are lipid vesicles that are able to encapsulate chemical compounds and are used for chronic drug delivery...
December 23, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
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