keyword
https://read.qxmd.com/read/38527995/non-lupus-full-house-nephropathy
#1
JOURNAL ARTICLE
Martina Uzzo, Andreas Kronbichler, Federico Alberici, Ingeborg Bajema
BACKGROUND: The presence of a full house pattern at immunofluorescence on kidney biopsy in a patient without clinical and laboratory features of systemic lupus erythematosus (SLE) has led to the descriptive term non-lupus full house nephropathy. This systematic review and meta-analysis focus on non-lupus full house nephropathy nomenclature, clinical findings and outcomes. METHODS: In a reiterative process, all identified terms for non-lupus full house nephropathy and other MeSH terms were searched in PubMed...
March 26, 2024: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/38525769/whipple-disease-presenting-as-isolated-transverse-myelitis-with-permanent-neurological-damage-in-a-patient-with-systemic-lupus-erythematosus-a-case-report-of-a-difficult-diagnosis-with-a-literature-review
#2
Carolina Saffioti, Marta Nebiolo, Roberta Caorsi, Alessio Mesini, Mariasavina Severino, Giacomo Brisca, Elio Castagnola, Marco Gattorno
We describe an atypical case of Whipple disease exclusively involving the spinal cord in an adolescent receiving immunosuppressive therapy for systemic lupus erythematosus. The diagnosis was particularly difficult since lupus and Whipple disease can present similar clinical features and the patient's prolonged contact with sewage was initially not mentioned. A literature review of the clinical, imaging, diagnostic, and therapeutic challenges of Whipple disease is also performed.
March 19, 2024: Infectious Disease Reports
https://read.qxmd.com/read/38524729/telitacicept-treatment-refractory-lupus-nephritis-a-case-report
#3
Sijia Li, Shuting Deng, Sichun Wen, Siqi Peng, Nan Jiang, Bohou Li, Boxi Chen, Ye Yuan, Qiong Wu, Yiming Tao, Jianchao Ma, Ting Lin, Feng Wen, Zhuo Li, Hao Dai, Renwei Huang, Zhonglin Feng, Zhilian Li, Shuangxin Liu, Lixia Xu
INTRODUCTION: Refractory lupus nephritis (LN) causes kidney disease progression and increases the risk of loss of renal function. Due to the high specificity and few side effects of biological agents, they are recommended for the treatment of systemic lupus erythematosus. There are few data on telitacicept for the treatment of refractory LN. CASE PRESENTATION: Here, we report the efficacy and safety of telitacicept in the treatment of refractory LN in a 25-year-old female patient...
2024: Case Reports in Nephrology and Dialysis
https://read.qxmd.com/read/38524519/reversal-of-complete-atrioventricular-block-in-dialysis-patients-following-parathyroidectomy-a-case-report
#4
Shan-Shan Xu, Li-Hai Hao, Yan-Meng Guan
BACKGROUND: Refractory secondary hyperparathyroidism (SHPT) is a common complication observed in patients with end-stage renal disease and can result in ectopic calcification. Metastatic calcification involving the heart valves and the conduction system can easily lead to arrhythmias, including atrioventricular block. This case report describes a maintenance hemodialysis patient with refractory SHPT resulting in a complete atrioventricular block (CAVB), which was eventually reversed to a first-degree atrioventricular block...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38518059/the-use-of-belimumab-on-patients-with-both-systemic-lupus-erythematosus-and-immune-thrombocytopenia-a-retrospective-cohort-study
#5
JOURNAL ARTICLE
Qi Wu, Ming-Xue Zhao, Xiao-Shan Huang, Chang-Song Lin, Qiang Xu
OBJECTIVE: The objective of this study is to provide a description of a group of retrospective cohort outcomes in patients with systemic lupus erythematosus (SLE) complicated with immune thrombocytopenia (ITP) receiving belimumab. METHODS: This study reports on the treatment of 10 female patients (mean age 34.3 ± 14.0 years, mean weight 58.7 ± 18.2 kg) with both SLE and ITP who received belimumab in addition to basic drug therapy. The belimumab treatment regimen consisted of a dosage of 10 mg/kg, with an initial infusion every 2 weeks for the first 3 doses, followed by an infusion every 4 weeks...
March 22, 2024: Lupus
https://read.qxmd.com/read/38516502/whipple-s-disease-presenting-with-a-chief-complaint-of-dyspnea-and-cough-from-pulmonary-invasion-without-evidence-of-gastrointestinal-involvement
#6
Michael Ladna, John George, Christopher E Forsmark
A patient with immune thrombocytopenia, systemic lupus erythematosus on chronic corticosteroids, and interstitial lung disease was referred to the pulmonology clinic due to progressively worsening dyspnea. A bronchoscopy was done and a thorough workup was negative for any infectious pathology or malignancy. A lung biopsy with MicroGenDX test (MicroGen Diagnostics, Lubbock, TX) revealed Tropheryma whipplei , consistent with a Whipple disease diagnosis. Histopathology of biopsy specimens from an esophagogastroduodenoscopy showed moderate chronic active Helicobacter gastritis and unremarkable duodenal specimens without evidence of Tropheryma whipplei ...
February 2024: Curēus
https://read.qxmd.com/read/38515165/exploring-paediatric-rheumatology-care-a-ten-year-retrospective-analysis-of-the-patient-population-in-ghana
#7
JOURNAL ARTICLE
Dzifa Dey, Bright Katso, Afia Baah, Saudatu Isaaka, Emmanuella Amoako
BACKGROUND: Rheumatic diseases can seriously impact children's general health, development, and growth. However, due to a lack of resources, paediatric rheumatology is a largely underdeveloped speciality in many African nations. Children with rheumatic disorders face obstacles in accessing specialized medical care, including lack of specialists, care centres, medication access, and limited research and education to increase understanding of paediatric rheumatic disease among healthcare practitioners...
March 21, 2024: Pediatric Rheumatology Online Journal
https://read.qxmd.com/read/38514392/improvement-of-high-density-lipoprotein-atheroprotective-properties-in-patients-with-systemic-lupus-erythematosus-after-belimumab-treatment
#8
JOURNAL ARTICLE
Anastasia-Georgia Dedemadi, Christina Gkolfinopoulou, Dimitra Nikoleri, Myrto Nikoloudaki, Hanna Ruhanen, Minna Holopainen, Reijo Kakela, Georgia Christopoulou, Stavros Bournazos, Pantelis Constantoulakis, Prodromos Sidiropoulos, George Bertsias, Angeliki Chroni
OBJECTIVE: Chronic inflammatory diseases, like Systemic Lupus Erythematosus (SLE), carry an increased risk for atherosclerosis and cardiovascular events, accompanied by impairment of atheroprotective properties of high-density lipoprotein (HDL). In SLE, serum BAFF (B cell-activating factor), a cytokine implicated in disease progression, has been correlated with subclinical atherosclerosis. We investigated the impact of treatment with belimumab -an anti-BAFF monoclonal antibody- on HDL atheroprotective properties and composition in SLE patients...
March 21, 2024: Rheumatology
https://read.qxmd.com/read/38514381/epidemiological-immunological-and-treatment-response-profile-of-patients-with-lupus-nephritis-in-brazil
#9
JOURNAL ARTICLE
Mariana Sousa Teixeira Nunes, Lectícia Barbosa Jorge, Luis Yu, Viktoria Woronik, Cristiane Bitencourt Dias
BACKGROUND AND HYPOTHESIS: Brazil has the largest number of individuals of African descent outside Africa and a very admixed population. Among cases of lupus nephritis (LN) in the country, there are differences in incidence, and even in severity, depending on the location and characteristics of the population studied. The aim of this study was to describe the clinical and epidemiological characteristics of LN in Brazil, as well as to determine which of those characteristics would be risk factors for a poor renal prognosis...
March 21, 2024: Lupus
https://read.qxmd.com/read/38509358/-current-patient-care-of-systematic-lupus-erythematosus-in-rhineland-palatinate-and-saarland
#10
JOURNAL ARTICLE
Ciaran Alberti, Matthias Dreher, Konstantinos Triantafyllias, Andreas Schwarting
BACKGROUND: Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease that is associated with great suffering for those affected, as well as high socioeconomic costs. Early diagnosis and adequate medical care are essential for a mild course of the disease. However, there is a lack of current figures and data on the care situation of patients in the area. METHODOLOGY: A total of 1546 general practitioners, rheumatologists, neurologists, nephrologists and dermatologists in Rhineland-Palatinate and Saarland were interviewed by fax or mail using a questionnaire regarding epidemiology, symptoms, therapy and therapy success...
March 20, 2024: Zeitschrift Für Rheumatologie
https://read.qxmd.com/read/38509241/a-retrospective-cohort-study-of-epstein-barr-virus-infection-status-and-systemic-lupus-erythematosus
#11
JOURNAL ARTICLE
Mengjie Chen, Jianxin Tu, Mingyu Huang, Yongjun Cheng, Li Sun
OBJECTIVES: Systemic lupus erythematosus (SLE) and the Epstein-Barr virus (EBV) are very closely related. This study estimated the impact of EBV infection status on clinical manifestations and disease remission in patients with SLE. METHOD: A retrospective study was performed using electronic health records of patients with SLE. The SLE disease activity index (SLEDAI-2 K) was used to assess disease activity. VCAIgM or EAIgM positive or EBVDNA copies ≥ 50 IU/mL were defined as lytic infection group, EBNA-IgG or VCAIgG-positive and who were negative for both VCAIgM and EAIgM with EBVDNA copies < 50 IU/mL were defined as the latent infection group...
March 20, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38504363/aeromonas-veronii-associated-endogenous-endophthalmitis-a-case-report
#12
JOURNAL ARTICLE
Jiali Lin, Haibin Zhong, Qi Chen, Ling Cui, Fan Xu, Fen Tang
BACKGROUND: Aeromonas veronii is a very rare and highly pathogenic microorganism. We investigate the clinical characteristics and significance of endogenous endophthalmitis caused by Aeromonas veronii in our patient. CASE PRESENTATION: A 30-year-old Asian women with systemic lupus erythematosus, uremia, and hypertension developed acute infectious endophthalmitis caused by Aeromonas veronii. After emergency vitrectomy and antibiotic therapy, the clinical condition worsened requiring enucleation...
March 20, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38502271/progressive-multifocal-leukoencephalopathy-associated-with-systemic-lupus-erythematosus-longitudinal-observation-of-lymphocytes-jc-virus-in-cerebrospinal-fluid-and-brain-magnetic-resonance-imaging
#13
JOURNAL ARTICLE
Hidetada Yamada, Megumi Toko, Masahiro Nakamori, Hiroki Ueno, Shiro Aoki, Tomohiro Sugimoto, Hiroko Yasutomi, Kazuo Nakamichi, Hirofumi Maruyama
Progressive multifocal leukoencephalopathy (PML) rarely occurs in patients with systemic lupus erythematosus (SLE). This report presents the case of a patient who developed PML due to SLE-associated multiple factors. A 60-year-old woman diagnosed with SLE undergoing multiple immunosuppressive therapies, including azathioprine, presented with cerebral cortical symptoms, lymphocytopenia, and vitamin B12 deficiency and was subsequently diagnosed with SLE-associated PML. We evaluated the cause and disease activity of PML, focusing on the longitudinal assessment of lymphocytopenia, JC virus (JCV) DNA copy number in the cerebrospinal fluid, and magnetic resonance imaging (MRI) findings...
March 19, 2024: Journal of Neurovirology
https://read.qxmd.com/read/38502235/systemic-lupus-erythematosus-presenting-with-atypical-hemolytic-uremic-syndrome-a-case-report-and-review-of-the-literature
#14
REVIEW
Justin Smith, Varinder Hans, Elaine Yacyshyn, Azin Rouhi, Monika Oliver
Systemic lupus erythematosus (SLE) can present with a diverse array of hematologic manifestations, among which atypical hemolytic uremic syndrome (aHUS) is a rare entity. SLE-triggered aHUS has significant morbidity and mortality without timely intervention, yet its frequency remains uncertain and optimal strategies for complement-directed therapies are largely expert-driven. We performed a comprehensive literature review and present a case of a 23-year-old female newly diagnosed with SLE/class IV lupus nephritis who developed aHUS that rapidly responded to the C5 antagonist, eculizumab...
March 19, 2024: Rheumatology International
https://read.qxmd.com/read/38502234/the-prevalence-of-neutropenia-and-association-with-infections-in-patients-with-systemic-lupus-erythematosus-a-swedish-single-center-study-conducted-over-14%C3%A2-years
#15
JOURNAL ARTICLE
Muna Saleh, Johanna Sjöwall, Marcus Bendtsen, Christopher Sjöwall
Hematologic abnormalities are common manifestations of SLE, although neutropenia is observed less frequently and is not included in the classification criteria. Nonetheless, neutropenia is a risk factor for infections, especially those caused by bacteria or fungi. We aimed to evaluate the impact of neutropenia in SLE through a systematic investigation of all infections in a large cohort of well-characterized patients, focusing on neutropenia, lymphopenia, and hypocomplementemia. Longitudinal clinical and laboratory parameters obtained at visits to the Rheumatology Unit, Linköping University Hospital, and linked data on all forms of healthcare utilization for all the subjects included in our regional SLE register during 2008-2022 were assessed...
March 19, 2024: Rheumatology International
https://read.qxmd.com/read/38496018/the-significance-of-biomarkers-of-inflammation-in-predicting-the-activity-of-lupus-nephritis
#16
JOURNAL ARTICLE
Violeta Rabrenović, Milica Petrović, Milorad Rabrenović, Dejan Pilčević, Nemanja Rančić
BACKGROUND: Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE). There are increased studies examining the role of different markers that would facilitate diagnosis, LN activity monitoring, relapse occurrence, and the right time to introduce maintenance therapy. We aimed to examine the importance of determining the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic immuneinflammatory index (SII) and systemic inflammatory response index (SIRI) in LN, comparing their significance with other standard parameters of active disease...
January 25, 2024: Journal of Medical Biochemistry
https://read.qxmd.com/read/38493673/anti-dna-antibody-targeted-d-peptide-nanoparticles-ameliorate-lupus-nephritis-in-mrl-lpr-mice
#17
JOURNAL ARTICLE
Yaqi Wang, Shuang Wang, Wei Liu, Hanjiang Gu, Mai Luo, Tong Xiao, Mingzhu Zhou, Yutong Ran, Shengxiang Xiao, Yumin Xia, Huixia Wang
Peptide ALW (ALWPPNLHAWVP) targeting anti-dsDNA antibodies has shown promising therapeutic effects in alleviating lupus nephritis, but is potentially limited by poor stability and non-kidney targeting. We recently developed a D-form modified ALW, called D-ALW, which has the capacity to widely inhibit pathogenic polyclonal anti-dsDNA antibody reactions. Further modification of D-ALW using PEG-PLGA nanoparticles to enhance good kidney-targeting ability and extend half-life. Here, we demonstrate that the D-form modified ALW maintains higher binding and inhibition efficiencies and achieves higher stability...
March 16, 2024: Journal of Autoimmunity
https://read.qxmd.com/read/38491743/an-update-on-clinical-trials-for-cutaneous-lupus-erythematosus
#18
REVIEW
Lillian Xie, Lais Lopes Almeida Gomes, Caroline J Stone, Daniella Forman Faden, Victoria P Werth
Cutaneous lupus erythematosus (CLE) comprises dermatologic manifestations that may occur independently or with systemic lupus erythematosus (SLE). Despite advancements in refining CLE classification, establishing precise subtype criteria remains challenging due to overlapping presentations and difficulty in distinguishing morphology. Current treatments encompass preventive measures, topical therapies, and systemic approaches. Hydroxychloroquine and glucocorticoids are the sole US Food and Drug Administration (FDA)-approved medications for CLE, with numerous off-label treatments available...
March 15, 2024: Journal of Dermatology
https://read.qxmd.com/read/38490946/global-tuberculosis-disease-and-infection-in-systemic-lupus-erythematosus-patients-a-systematic-review-and-meta-analysis
#19
JOURNAL ARTICLE
Guntur Darmawan, Lie Monica Sherine Liman, Suryo Anggoro Kusumo Wibowo, Laniyati Hamijoyo, Lika Apriani, Nur Atik, Bachti Alisjahbana, Edhyana Sahiratmadja
BACKGROUND: Tuberculosis (TB) is one of the most common infections among systemic lupus erythematosus (SLE) patients. We aimed to evaluate the global prevalence of TB infection and disease, its type, and medication risk factors in SLE patients. METHODS: We searched PubMed, Science Direct, EBSCO, and Web of Science databases from inception to April 30, 2023, and included studies assessing TB among SLE patients. We estimated the prevalence of TB disease (including type of TB disease), TB infection, and SLE medication as TB risk factors...
March 15, 2024: Lupus
https://read.qxmd.com/read/38481930/a-tailored-physiotherapy-program-in-a-rare-case-of-bilateral-territorial-cerebral-artery-infarction-with-systemic-lupus-nephritis-a-case-report
#20
Reva D Rajurkar, Nikita H Seth, Nishigandha P Deodhe, Neha Arya
A stroke is a medical emergency that requires rapid treatment. Early intervention can help prevent brain damage and other negative consequences. An ischemic stroke occurs when a blood clot blocks or narrows a blood artery leading to the brain. Systemic lupus erythematosus (SLE) is characterized by systemic inflammation, autoantibodies, and a relapsing-remitting illness. Patients with SLE have an increased cumulative risk of cardiovascular events, including stroke, especially in the first five years after diagnosis...
February 2024: Curēus
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