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https://www.readbyqxmd.com/read/28820618/college-women-s-responses-to-a-celebrity-health-disclosure
#1
Julia H Drizin, Vanessa L Malcarne, Melody K Schiaffino, Kristen J Wells
Celebrities can have a powerful influence on people's health-related attitudes and behaviors, often by publicly disclosing their own personal health decisions. In May 2013, Angelina Jolie, an internationally recognized actress, director, and author, wrote an op-ed for the New York Times disclosing her decision to undergo a prophylactic double mastectomy to reduce her risk of breast cancer after learning that she carried the BRCA1 gene mutation. This cross-sectional study examined whether exposure to Angelina Jolie and her mastectomy disclosure and parasocial involvement (PSI) with Angelina Jolie were related to female college students' perceived risk of breast cancer and breast cancer screening intentions...
August 18, 2017: Health Communication
https://www.readbyqxmd.com/read/28820613/influence-of-paddock-size-on-social-relationships-in-domestic-horses
#2
Katarzyna Majecka, Aneta Klawe
The aim of this study was to explore whether the size of paddocks affected social interactions within a group of horses. Furthermore, the effects of the gender composition in groups on social behavior were investigated. The research was done in a horse-riding center. A total of 78 horses and ponies, forming 3 groups, were included in the study. The time of the observation was divided into 2 periods. The data obtained from the 1st period (the horses were on relatively small paddocks) and the 2nd period (the paddocks were significantly bigger) were compared...
August 18, 2017: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/28820488/phase-behaviour-and-miscibility-studies-of-collagen-silk-fibroin-macromolecular-system-in-dilute-solutions-and-solid-state
#3
Ima Ghaeli, Mariana A de Moraes, Marisa M Beppu, Katarzyna Lewandowska, Alina Sionkowska, Frederico Ferreira-da-Silva, Maria P Ferraz, Fernando J Monteiro
Miscibility is an important issue in biopolymer blends for analysis of the behavior of polymer pairs through the detection of phase separation and improvement of the mechanical and physical properties of the blend. This study presents the formulation of a stable and one-phase mixture of collagen and regenerated silk fibroin (RSF), with the highest miscibility ratio between these two macromolecules, through inducing electrostatic interactions, using salt ions. For this aim, a ternary phase diagram was experimentally built for the mixtures, based on observations of phase behavior of blend solutions with various ratios...
August 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28820391/deep-brain-stimulation-alters-light-phase-food-intake-microstructure-in-rats
#4
P Prinz, P Kobelt, S Scharner, M Goebel-Stengel, D Harnack, K Faust, Y Winter, M Rose, A Stengel
Treatment of eating disorders like obesity or anorexia is challenging. Options are limited and new approaches desired. An interesting approach is the application of deep brain stimulation (DBS). The nucleus accumbens (NAcc) is part of the food reward system. A pilot study reported that DBS of the NAcc shell modulates food intake and body weight in rats. Underlying mechanisms such as the food intake microstructure are unknown so far. Normal weight female Sprague-Dawley rats were equipped with a custom-made DBS electrode placed unilaterally in the NAcc shell...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28820220/real-time-plasmon-spectroscopy-study-of-the-solid-state-oxidation-and-kirkendall-void-formation-in-copper-nanoparticles
#5
Mariano D Susman, Yishai Feldman, Tatyana A Bendikov, Alexander Vaskevich, Israel Rubinstein
Oxidation and corrosion reactions have a major effect on the application of non-noble metals. Kinetic information and simple theoretical models are often insufficient for describing such processes in metals at the nanoscale, particularly in cases involving formation of internal voids (nano Kirkendall effect, NKE) during oxidation. Here we study the kinetics of solid-state oxidation of chemically-grown copper nanoparticles (NPs) by in situ localized surface plasmon resonance (LSPR) spectroscopy during isothermal annealing in the range 110-170 °C...
August 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28819988/behavior-change-following-hiv-diagnosis-findings-from-a-cohort-of-los-angeles-msm
#6
Pamina M Gorbach, Marjan Javanbakht, Robert K Bolan
The effect of an HIV diagnosis on subsequent behavior of men who have sex with men (MSM) remains unclear. From 2009 to 2012 the NIDA funded Metromates Study enrolled and followed for one year MSM seeking testing for HIV in Los Angeles, assessing those with new HIV diagnoses for acute/recent HIV infection. Behavioral data were collected via Computer-Assisted Self-Interview from 321 men of whom 125 were classified as recently HIV infected, 91 as not recently HIV infected, and 105 as HIV-negative. Differences over time between those with recent HIV infection, not recent HIV infection, and no HIV were evaluated using bivariate and multivariable analyses for repeat measures to assess associations between HIV group, behaviors and condomless receptive (CRAI), intersertive (CIAI), or any condomless anal intercourse (CAI)...
August 18, 2017: AIDS Care
https://www.readbyqxmd.com/read/28819922/therapeutic-alliance-client-need-for-approval-and-perfectionism-as-differential-moderators-of-response-to-ehealth-and-traditionally-delivered-treatments-for-comorbid-depression-and-substance-use-problems
#7
Frances J Kay-Lambkin, Amanda L Baker, Kerrin Palazzi, Terry J Lewin, Brian J Kelly
PURPOSE: This study sought to undertake an exploratory analysis of the impact of therapeutic alliance and dysfunctional attitudes (perfectionism and need for approval) on outcomes for participants receiving therapist-delivered and eHealth interventions for comorbid depression and alcohol/cannabis use problems. These factors have been shown in previous research to moderate response to psychological treatment for depression and related disorders. METHOD: Participants (N = 274) with concurrent depression and alcohol/cannabis misuse were randomized to 10 sessions of therapist-delivered cognitive behavior therapy/motivational interviewing (CBT/MI), computer-delivered CBT/MI with brief therapist assistance (SHADE CBT/MI), or supportive counseling (PCT)...
August 17, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28819756/nanofibers-grafted-on-titanium-alloy-the-effects-of-fiber-alignment-and-density-on-osteoblast-mineralization
#8
Hsin-Yi Lin, Zhao-Xiang Peng
The surface of medical implant alloy Ti-6Al-4V was chemically modified to allow it to covalently bond with collagen/PVA nanofibers. These nanofibers were successfully attached to the Ti-6Al-4V surface in three different morphologies: randomly oriented high-density fiber, COL(H); randomly oriented low-density fiber, COL(L); and aligned high-density fiber, COL(A). The effects of the morphology of these covalently-bound collagen nanofibers on the growth and differentiation of osteoblasts were studied for 21 days...
August 17, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28819456/therapeutic-effect-of-astroglia-like-mesenchymal-stem-cells-expressing-glutamate-transporter-in-a-genetic-rat-model-of-depression
#9
Amit Shwartz, Oshra Betzer, Noam Kronfeld, Gila Kazimirsky, Simona Cazacu, Susan Finniss, Hae Kyung Lee, Menachem Motiei, Shani Yael Dagan, Rachela Popovtzer, Chaya Brodie, Gal Yadid
Recent studies have proposed that abnormal glutamatergic neurotransmission and glial pathology play an important role in the etiology and manifestation of depression. It was postulated that restoration of normal glutamatergic transmission, by enhancing glutamate uptake, may have a beneficial effect on depression. We examined this hypothesis using unique human glial-like mesenchymal stem cells (MSCs), which in addition to inherent properties of migration to regions of injury and secretion of neurotrophic factors, were differentiated to express high levels of functional glutamate transporters (excitatory amino acid transporters; EAAT)...
2017: Theranostics
https://www.readbyqxmd.com/read/28819427/develop-and-validation-a-nomogram-to-predict-the-recurrent-probability-in-patients-with-major-salivary-gland-cancer
#10
Chang-Hsien Lu, Chien-Ting Liu, Pei-Hung Chang, Chia-Yen Hung, Shau-Hsuan Li, Ta-Sen Yeh, Yung-Shin Hung, Wen-Chi Chou
Objectives: Prediction of recurrent risk in patients with major salivary gland carcinoma (MSGC) after surgical treatment is an important but difficult task because of a broad spectrum of tumor histological subtypes and diverse clinical behaviors. This study aimed to develop and validate a nomogram to predict the recurrent probability in patients with MSGC. Methods: A total of 231 consecutive patients with MSGC received curative-intend surgery between 2002 and 2014 from one medical center were selected as the training set...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819408/opposite-effects-of-set7-9-on-apoptosis-of-human-acute-myeloid-leukemia-cells-and-lung-cancer-cells
#11
Ye Gu, Yuan Wang, Xinling Wang, Lili Gao, Weiping Yu, Wei-Feng Dong
SET7/9 is a protein lysine methyltransferases (PLMTs or PKMTs) which methylates both histone H3K4 and non-histone proteins including transcriptional factors, tumor suppressors, and membrane-associated receptors. Methylation of these proteins alters protein activity and leads to changes in cellular behavior and a series of biological processes. This study aims to investigate the role of SET7/9 in human acute myeloid leukemia (AML) and non-small-cell lung cancer (NSCLC). We examined the expression of SET7/9 in AML cells and NSCLC cells and detected the methylation status of the SET7/9 promoter region...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819132/treatment-associated-changes-of-functional-connectivity-of-midbrain-brainstem-nuclei-in-major-depressive-disorder
#12
Gerd Wagner, Feliberto de la Cruz, Stefanie Köhler, Karl-Jürgen Bär
Previous functional magnetic resonance imaging (fMRI) studies demonstrated an abnormally coordinated network functioning in Major Depression Disorder (MDD) during rest. The main monoamine-producing nuclei within midbrain/brainstem are functionally integrated within these specific networks. Therefore, we aimed to investigate the resting-state functional connectivity (RSFC) of these nuclei in 45 MDD patients and differences between patients receiving two different classes of antidepressant drugs. Patients showed reduced RSFC from the ventral tegmental area (VTA) to dorsal anterior cingulate cortex (dACC) and stronger RSFC to the left amygdala and dorsolateral prefrontal cortex (DLPFC)...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819107/medial-prefrontal-cortical-thinning-mediates-shifts-in-other-regarding-preferences-during-adolescence
#13
Sunhae Sul, Berna Güroğlu, Eveline A Crone, Luke J Chang
Adolescence is a time of significant cortical changes in the 'social brain', a set of brain regions involved in sophisticated social inference. However, there is limited evidence linking the structural changes in social brain to development of social behavior. The present study investigated how cortical development of the social brain relates to other-regarding behavior, in the context of fairness concerns. Participants aged between 9 to 23 years old responded to multiple rounds of ultimatum game proposals...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819027/combination-therapy-with-bispecific-antibodies-and-pd-1-blockade-enhances-the-antitumor-potency-of-t-cells
#14
Chien-Hsing Chang, Yang Wang, Rongxiu Li, Diane L Rossi, Donglin Liu, Edmund A Rossi, Thomas M Cardillo, David M Goldenberg
The DOCK-AND-LOCK (DNL®) method is a platform technology that combines recombinant engineering and site-specific conjugation to create multispecific, multivalent antibodies of defined composition with retained bioactivity. We have applied DNL® to generate a novel class of trivalent bispecific antibodies (bsAbs), each comprising an anti-CD3 scFv covalently conjugated to a stabilized dimer of different anti-tumor Fabs. Here we report the further characterization of two such constructs, (E1)-3s and (14)-3s, which activate T cells and target Trop-2- and CEACAM5-expressing cancer cells, respectively...
August 17, 2017: Cancer Research
https://www.readbyqxmd.com/read/28818693/hybrid-photoacoustic-and-electrophysiological-recording-of-neurovascular-communications-in-freely-moving-rats
#15
Lei Xi, Tian Jin, Junli Zhou, Paul Carney, Hubei Jiang
Uncovering the relationships between neural activities and capillary-level hemodynamics such as blood flow and concentration of hemoglobin in the brain plays an important role in the study of animal behaviors and brain disorders. Here, we developed a miniature probe integrating a photoacoustic sensor and micro-electrodes to simultaneously record the dynamics of blood flow and total hemoglobin inside a single capillary and the activities of surrounding neurons with high spatiotemporal resolution in freely-moving rats...
August 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28818688/anodization-of-magnesium-for-biomedical-applications-processing-characterization-degradation-and-cytocompatibility
#16
Aaron F Cipriano, Jiajia Lin, Christopher Miller, Alan Lin, Mayra C Cortez Alcaraz, Pedro Soria, Huinan Liu
This article reports anodization of Mg in KOH electrolyte and the associated surface, degradation, and biological properties for bioresorbable implant applications. The preparation procedures for electrodes and anodization setup significantly enhanced reproducibility of samples. The results of anodization performed at the applied potentials of 1.8, 1.9, or 2.0 V showed that the sample anodized at 1.9 V and annealed, referred to as the 1.9 AA sample, had homogenous surface microstructure and elemental composition, and a reduction in corrosion current density in the electrochemical testing...
August 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28818681/sanction-changes-and-drunk-driving-injuries-deaths-in-taiwan
#17
Yun-Shan Chan, Chin-Shyan Chen, Lanying Huang, Yu-I Peng
Driving under the influence (DUI) is one of the major causes of traffic accidents in Taiwan. About 5% of injuries involve DUI, and nearly 20% of deaths are due to alcohol-related crashes. During early 2006 to the end of 2014, the authorities in Taiwan increased the severity of fine and jail penalties for DUI offenders three times. At the same time, the monthly drunk-driving injures decreased nearly 40% and the monthly alcohol-related traffic death dropped more than 80%. In this paper, we examine the effects of sanction changes on the reduction of drunk-driving casualties during this period...
August 14, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28818643/combined-effects-of-oil-exposure-temperature-and-ultraviolet-radiation-on-buoyancy-and-oxygen-consumption-of-embryonic-mahi-mahi-coryphaena-hippurus
#18
Christina Pasparakis, Lauren E Sweet, John D Stieglitz, Daniel Benetti, Conrad T Casente, Aaron P Roberts, Martin Grosell
The Deepwater Horizon oil spill occurred in the summer of 2010 and coincided with the spawning window of the ecologically and economically important pelagic fish mahi-mahi (Coryphaena hippurus). During summer months, early life stage mahi-mahi were likely also exposed to other naturally occurring stressors such as increased temperature and ultraviolet radiation (UV). Previous research has shown that co-exposure to oil and additional natural stressors can affect the timing and duration of negative buoyancy in mahi-mahi embryos...
August 5, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28818417/referral-for-expert-physical-activity-counseling-a-pragmatic-rct
#19
Erica L James, Ben D Ewald, Natalie A Johnson, Fiona G Stacey, Wendy J Brown, Elizabeth G Holliday, Mark Jones, Fan Yang, Charlotte Hespe, Ronald C Plotnikoff
INTRODUCTION: Primary care physicians are well placed to offer physical activity counseling, but insufficient time is a barrier. Referral to an exercise specialist is an alternative. In Australia, exercise specialists are publicly funded to provide face-to-face counseling to patients who have an existing chronic illness. This trial aimed to (1) determine the efficacy of primary care physicians' referral of insufficiently active patients for counseling to increase physical activity, compared with usual care, and (2) compare the efficacy of face-to-face counseling with counseling predominantly via telephone...
August 14, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28818400/characterization-of-the-constitutive-behavior-of-municipal-solid-waste-considering-particle-compressibility
#20
Xilin Lü, Xinle Zhai, Maosong Huang
This paper presents a characterization of the mechanical behavior of municipal solid waste (MSW) under consolidated drained and undrained triaxial conditions. The constitutive model was established based on a deviatoric hardening plasticity model. A power form function and incremental hyperbolic form function were proposed to describe the shear strength and the hardening role of MSW. The stress ratio that corresponds to the zero dilatancy was not fixed but depended on mean stress, making the Rowe's rule be able to describe the stress-dilatancy of MSW...
August 14, 2017: Waste Management
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