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https://www.readbyqxmd.com/read/29445911/high-prevalence-of-hcv-gt4-related-tsh-abnormality-among-13402-egyptian-patients-treated-with-direct-acting-antiviral-therapy
#1
Rasha Eletreby, Mohamed Said, Zeinab Abdellatif, Yasmin Saad, Magdy ElSerafy, Hosam Dabes, Kadry ElSaeed, Yehia El-Shazly, Wahid Doss
BACKGROUND: HCV is associated with several extra hepatic diseases including thyroid dysfunction. This study aims at evaluating prevalence of thyroid dysfunction and its possible predictors in a large cohort of HCV GT4-infected patients, and the role of thyroid dysfunction as a predictor of response in the setting of direct acting antivirals (DAAs). METHODS: Patients registered on the web-based registry system to receive therapy for chronic HCV in Beheira governorate viral hepatitis specialized treatment center affiliated to the National committee for control of viral hepatitis (NCCVH), Ministry of health, Egypt in the period from January 2015 to October 2016...
February 14, 2018: Hepatology International
https://www.readbyqxmd.com/read/29445473/graves-disease-coexisting-with-resistance-to-thyroid-hormone-a-rare-case
#2
Hongping Sun, Shuhang Xu, Shaofeng Xie, Wen Cao, Guofang Chen, Hongjie Di, Rendong Zheng, Xingjia Li, Xiaodong Mao, Chao Liu
A rare case of resistance to thyroid hormone (RTH) complicated with Graves' hyperthyroidism was reported. The management of this disease is similar to that of Graves' disease. Antithyroid drug therapy is the first choice, and iodine therapy and surgery are not recommended due to the possibility of severe hypothyroidism and enlargement of the pituitary gland.
February 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29444549/body-weight-change-is-unpredictable-after-total-thyroidectomy
#3
Ron Glick, Paula Chang, Peter Michail, Jonathan W Serpell, Simon Grodski, James C Lee
BACKGROUND: There is a common perception that total thyroidectomy causes weight gain beyond expected age-related changes, even when thyroid replacement therapy induces a euthyroid state. The aim of this study was to determine whether patients who underwent total thyroidectomy for a wide spectrum of conditions experienced weight gain following surgery. METHODS: We retrospectively studied 107 consecutive total thyroidectomy patients treated between January 2013 and June 2014...
February 14, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29443784/a-thyroid-storm-patient-with-protracted-disturbance-of-consciousness-and-reversible-lesion-in-the-splenium-of-corpus-callosum-a-case-report
#4
Chihiro Namatame, Tomohiro Sonoo, Kazutaka Fukushima, Hiromu Naraba, Hideki Hashimoto, Kensuke Nakamura
RATIONALE: Various neurological manifestations are observed in thyroid storm patients but protracted disturbance of consciousness is rare. PATIENT CONCERNS: A 58-year-old male was admitted to our hospital after a traffic accident. DIAGNOSES: Although awake on arrival, he fell into coma after admission. Based on the clinical symptoms and hyperthyroidism, the patient was diagnosed with thyroid storm (TS). INTERVENTIONS: Even after improvement of hyperthyroidism, disturbance of consciousness was protracted...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29442081/qualitative-and-quantitative-salivary-changes-and-subjective-oral-dryness-among-patients-with-thyroid-dysfunction
#5
Meghal Mehul Naik, Vaishnavee Vassandacoumara
Context: There is a paucity of literature regarding the effects of thyroid disorders on the oral cavity by influencing the salivary gland function. Aims: This study aims to understand the qualitative and quantitative changes that thyroid disorder can cause in the salivary function. Settings and Design: After obtaining ethical clearance, 46 consecutive newly diagnosed thyroid dysfunction patients were enrolled in this cross-sectional study, along with 45 age-and sex-matched controls...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29441165/propylthiouracil-induced-anca-negative-cutaneous-small-vessel-vasculitis
#6
Aliaksandr Trusau, Michael L Brit
Propylthiouracil (PTU) is a commonly used medication for the treatment of hyperthyroidism. PTU is known to cause different adverse reactions including autoimmune syndromes. PTU-induced autoimmune syndromes can be classified into drug-induced lupus or drug-induced vasculitis. Differential diagnoses could be very challenging. PTU-induced vasculitis is more common than PTU-induced lupus, and has a higher risk of morbidity and mortality. Usually it is limited to the skin in a form of cutaneous leukocytoclastic vasculitis, but may also affect organs including kidneys and lungs...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29439614/effect-of-thyroglobulin-autoantibodies-on-the-metabolic-clearance-of-serum-thyroglobulin
#7
Francesco Latrofa, Debora Ricci, Sara Bottai, Federica Brozzi, Luca Chiovato, Paolo Piaggi, Michele Marino, Paolo Vitti
BACKGROUND: To establish whether thyroglobulin autoantibodies (TgAb) influence the metabolic clearance of thyroglobulin (Tg) in humans, we correlated serum Tg and TgAb shortly after 131I treatment. METHODS: Samples were collected from 30 consecutive patients undergoing 131I activity for Graves' hyperthyroidism at the time of treatment and every 15 days thereafter, up to 90 days. Tg and TgAb were measured by immunometric assays (functional sensitivities: 0.1 ng/mL and 8 IU/mL)...
February 14, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29435670/diagnostic-accuracy-of-a-new-fluoroenzyme-immunoassay-for-the-detection-of-tsh-receptor-autoantibodies-in-graves-disease
#8
Danilo Villalta, Federica D'Aurizio, Mirella Da Re, Debora Ricci, Francesco Latrofa, Renato Tozzoli
PURPOSE: Thyrotropin receptor (TSHR) autoantibodies (TRAbs) are a hallmark of Graves' disease (GD). The aim of this study was to evaluate the diagnostic accuracy of a new third generation automatic fluorescence enzyme immunoassay for TRAb measurement in GD, in comparison with two current IMAs. METHODS: Sera of 439 subjects (57 patients with untreated GD, 34 with treated GD, 15 with GD and Graves' orbitopathy, 52 with multinodular non-toxic goiter, 86 with Hashimoto's thyroiditis, 20 with toxic adenoma or toxic multinodular goiter, 55 with non-thyroid autoimmune diseases and 120 normal controls) were tested for TRAbs with the ELiA ™ anti-TSH-R assay (ThermoFischer Scientific, Uppsala, Sweden), the TRAK ™ RIA, Brahms (Thermo Scientific, Hennigsdorf, Germany) and the Immulite ™ TSI assay (Siemens Healthcare, Llanberis, UK)...
February 12, 2018: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/29434126/a-case-of-heart-failure-with-hyperthyroidism-demonstrating-discrepancy-between-the-clinical-course-and-b-type-natriuretic-peptide-levels
#9
Chiaki Kishida, Ryo Naito, Hiroki Kasuya, Tomohiro Kaneko, Kosuke Yabe, Midori Kakihara, Ryosuke Shimai, Hiroyuki Isogai, Dai Ozaki, Yuki Yasuda, Fuminori Odagiri, Tetsuro Miyazaki, Ken Yokoyama, Takashi Tokano, Hajime Koyano, Yuji Nakazato
A 35-year-old Japanese man was emergently admitted to our hospital with chief complaints of palpitation and dyspnea. He has been treated for Basedow's disease. He was diagnosed with acute decompensated heart failure, atrial fibrillation and thyrotoxicosis. We started anti-thyroid agents and a treatment for heart failure with beta blockers and diuretics under anti-coagulation therapy. His B-type natriuretic peptide levels remained high, although the heart failure had been compensated and the heart rate was well controlled while hyperthyroidism still existed...
February 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29434028/effects-of-thyroid-hormones-on-thermogenesis-and-energy-partitioning
#10
Karl Alexander Iwen, Rebecca Ölkrug, Georg Brabant
Thyroid hormones (TH) are of central importance for thermogenesis, energy homeostasis, and metabolism. Here we will discuss these aspects by focussing on the physiological aspects of TH-dependent regulation in response to cold exposure and fasting which will be compared to alterations in primary hyper- and hypothyroidism. In particular, we will summarise current knowledge on regional thyroid hormone status in the central nervous system (CNS) and in peripheral cells. In contrast to hyper- and hypothyroidism, where parallel changes are observed, local alterations in the CNS differ to peripheral compartments when induced by cold exposure or fasting...
February 6, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29432704/clinicopathological-features-and-comorbidities-of-cats-with-mild-moderate-or-severe-hyperthyroidism-a-radioiodine-referral-population
#11
Natalie Watson, Jane K Murray, Sonja Fonfara, Angie Hibbert
Objectives This study sought to explore the clinicopathological features and comorbidities of cats with mild, moderate and severe hyperthyroidism in a radioiodine referral population. Methods Medical records were reviewed, along with results of serum biochemistry, urinalysis, systolic blood pressure and diagnostic imaging performed at the time of radioiodine referral. Cats were grouped by total thyroxine (TT4) levels as mildly (TT4 60.1-124.9 nmol/l), moderately (TT4 125-250 nmol/l) or severely (TT4 >250 nmol/l) hyperthyroid at the time of diagnosis and referral...
February 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29430221/successful-treatment-of-oral-lichen-planus-with-direct-acting-antiviral-agents-after-liver-transplantation-for-hepatitis-c-virus-associated-hepatocellular-carcinoma
#12
Yumiko Nagao, Kazunori Nakasone, Tatsuji Maeshiro, Nao Nishida, Kanae Kimura, Yuji Kawahigashi, Yasuhito Tanaka, Michio Sata
Hepatitis C virus (HCV) infection is frequently associated with various extrahepatic manifestations, such as autoimmune features and immune complex deposit diseases. Oral lichen planus (OLP) is one such extrahepatic manifestation of HCV infection. Recently, direct-acting antivirals (DAA) have proved to be highly effective and safe for the eradication of HCV. Herein, we report a case of OLP accompanied by HCV-related hepatocellular carcinoma (HCC) that disappeared after liver transplantation and achievement of sustained virological response following interferon (IFN)-free treatment with ledipasvir (LDV) and sofosbuvir (SOF)...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29412382/thyroid-disorders-in-obese-patients-does-insulin-resistance-make-a-difference
#13
Nicoleta Răcătăianu, Nicoleta Leach, Cosmina Ioana Bondor, Smaranda Mârza, Daniela Moga, Ana Valea, Cristina Ghervan
OBJECTIVE: The aim of this study was to evaluate the association between insulin resistance and thyroid pathology in obese patients, and compare the results between insulin-resistant and noninsulin-resistant patients. SUBJECTS AND METHODS: Obese/nondiabetic patients, aged 18-70 years, attending the outpatient endocrinology service for 2 years were consecutively included. We evaluated the patients' fasting plasma glucose, insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), thyroid-stimulating hormone (TSH), free thyroxine (FT4), antithyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (Tg-Ab), and thyroid ultrasound...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29409365/a-single-session-of-laser-ablation-for-toxic-thyroid-nodules-three-year-follow-up-results
#14
Giovanni Gambelunghe, Elisa Stefanetti, Renato Colella, Massimo Monacelli, Nicola Avenia, Pierpaolo De Feo
PURPOSE: To confirm the effectiveness of laser ablation on toxic nodules in a large population with three years of follow-up. MATERIAL AND METHODS: Between 2009 and 2014, we treated 82 patients with hyperthyroidism related to the presence of a toxic nodular goiter. Patients were pre-treated pharmacologically with methimazole prior to single session of laser ablation (LA) and then followed up every 3 months with FT4 and TSH blood tests as well as ultrasound examination of the nodules treated...
February 6, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29407445/thyroid-hormone-role-and-economy-in-the-developing-testis
#15
Arturo Hernandez
Thyroid hormones (TH) exhibit pleiotropic regulatory effects on growth, development, and metabolism, and it is becoming increasingly apparent that the developing testis is an important target for them. Testicular development is highly dependent on TH status. Both hypo- and hyperthyroidism affect testis size and the proliferation and differentiation of Sertoli, Leydig, and germ cells, with consequences for steroidogenesis, spermatogenesis, and male fertility. These observations suggest that an appropriate content of TH and by implication TH action in the testis, whether the result of systemic hormonal levels or regulatory mechanisms at the local level, is critical for normal testicular and reproductive function...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29407440/thyroid-hormone-in-the-cns-contribution-of-neuron-glia-interaction
#16
Mami Noda
The endocrine system and the central nervous system (CNS) are intimately linked. Among hormones closely related to the nervous system, thyroid hormones (THs) are critical for the regulation of development and differentiation of neurons and neuroglia and hence for development and function of the CNS. T3 (3,3',5-triiodothyronine), an active form of TH, is important not only for neuronal development but also for differentiation of astrocytes and oligodendrocytes, and for microglial development. In adult brain, T3 affects glial morphology with sex- and age-dependent manner and therefore may affect their function, leading to influence on neuron-glia interaction...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29407433/thyroid-hormone-receptor-antagonists-from-environmental-pollution-to-novel-small-molecules
#17
Louise S Mackenzie
Thyroid hormone receptors (TRs) are nuclear receptors which control transcription, and thereby have effects in all cells within the body. TRs are an important regulator in many basic physiological processes including development, growth, metabolism, and cardiac function. The hyperthyroid condition results from an over production of thyroid hormones resulting in a continual stimulation of thyroid receptors which is detrimental for the patient. Therapies for hyperthyroidism are available, but there is a need for new small molecules that act as TR antagonists to treat hyperthyroidism...
2018: Vitamins and Hormones
https://www.readbyqxmd.com/read/29406821/effect-of-goiter-dispersion-formula-on-serum-cytokines-in-hyperthyroidism-patients-with-neurologic-manifestations-of-graves-disease-a-randomized-trial-on-80-cases
#18
Wen-Hong Tian, Ying Wang, Rui Yang, Hai-Bing Hu
PURPOSE: This study is aimed to explore the combined use of goiter dispersion formula and antithyroid drugs in the treatment of patients with neurologic manifestations of Graves' disease by examining its modulating effects on patients' cytokines. METHODS: A total of 80 patients with Graves' disease were randomly divided into treatment and control groups. Patients of the treatment group received goiter dispersion formula and antithyroid drugs (methimazole or propylthiouracil), whereas those of the control group received antithyroid drug alone...
February 6, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29406005/neonatal-thyrotoxicosis
#19
REVIEW
Stephanie L Samuels, Sisi M Namoc, Andrew J Bauer
Neonatal thyrotoxicosis (hyperthyroidism) is less prevalent than congenital hypothyroidism; however, it can lead to significant morbidity and mortality if not promptly recognized and adequately treated. Most cases are transient, secondary to maternal autoimmune hyperthyroidism (Graves disease [GD]). This article summarizes recommendations for screening and management of hyperthyroidism in both the fetal and neonatal periods, with a focus on neonatal thyrotoxicosis secondary to maternal GD. Early monitoring and treatment are crucial for optimizing short-term and long-term patient outcomes...
March 2018: Clinics in Perinatology
https://www.readbyqxmd.com/read/29405728/both-experimental-hypothyroidism-and-hyperthyroidism-increase-cardiac-irisin-levels-in-rats
#20
E Atici, E Menevse, A K Baltaci, R Mogulkoc
Irisin is a newly discovered myokine and adipokine that increases total body energy expenditure. The aim of this study was to determine the effect of experimental hypothyroidism and hyperthyroidism on the levels of irisin in heart tissue in rats. The study was performed on the 40 male Sprague-Dawley rats. Experimental groups were designed as; Control, Hypothyroidism, Hypothyroidism+L-Thyroxine, Hyperthyroidism and Hyperthyroidism + PTU. Following 3 weeks experimental period, irisin levels were determined in heart tissues...
2018: Bratislavské Lekárske Listy
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