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Rajini K Yatavelli, Steven N Levine
OBJECTIVES: Transient hyperthyroidism has been documented following surgical manipulation or direct trauma to the normal thyroid gland. This has best been studied in patients following parathyroidectomy and also reported following trauma to the neck, strangulation, and vigorous palpation of the thyroid gland. It has not previously been reported following a thyroid ultrasound. METHODS: We report the case of a 58-year-old euthyroid woman with a large nontoxic multinodular goiter who developed transient hyperthyroidism following an ultrasound of the thyroid gland...
June 1, 2018: Annals of Otology, Rhinology, and Laryngology
Satyendra Kumar Sonkar, Satish Kumar, Neeraj Kumar Singh
Hypokalemia is a serious and life-threatening clinical condition. We present a case of a 45-year-old male, with known hyperthyroidism presenting with profound tremor, irritability, quadriparesis, and labored breathing since morning, on the day of admission. Arterial blood gas analysis showed severe hypokalemia. Patient's vital was stabilized and patient's oxygen saturation was maintained on oxygen inhalation. Intravenous potassium chloride infusion was administered with regular monitoring of vitals and electrolytes...
May 2018: Indian Journal of Critical Care Medicine
Ana M Ramos-Levi, Jacobo Rogado, Jose Miguel Sanchez-Torres, Ramón Colomer, Mónica Marazuela
BACKGROUND: Nivolumab is an anti-cancer monoclonal antibody that inhibits PD1 and modulates T-cell response. It has been shown to significantly improve survival in several types of cancer, but clinical trials have also reported an increased risk of developing immune-related adverse events (IRAEs). Endocrine IRAEs may be particularly relevant. OBJECTIVE: To comprehensively evaluate the clinical presentation of endocrine IRAEs in patients with lung cancer treated with nivolumab...
June 14, 2018: Endocrinología, Diabetes y Nutrición
Srishti Shrestha, Christine G Parks, Whitney S Goldner, Freya Kamel, David M Umbach, Mary H Ward, Catherine C Lerro, Stella Koutros, Jonathan N Hofmann, Laura E Beane Freeman, Dale P Sandler
BACKGROUND: Little is known about modifiable risk factors for thyroid disease. Several pesticides have been implicated in thyroid disruption, but clinical implications are not clear. OBJECTIVE: We assessed associations between pesticide use and other farm exposures and incident hypothyroidism and hyperthyroidism in female spouses of farmers in the Agricultural Health Study (AHS). METHODS: We used Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals for risk of thyroid disease in 24,092 spouses who completed at least one follow-up questionnaire...
June 13, 2018: Environment International
Loizos C Siakallis, Jimmy M Uddin, Katherine A Miszkiel
INTRODUCTION: Thyroid eye disease (TED), is a term referring to the extrathyroidal manifestation of Grave's disease, a disorder which is currently the most common cause of hyperthyroidism and is characterised by underlying autoimmunity.The pathogenic course of the disease can be broadly classified into two stages, an early inflammatory and a late fibrotic stage. These stages are reflected in clinical severity and activity classifications, such as Clinical Activity Score and Class 0: No signs or symptoms, 1: Only signs, no symptoms (e...
June 13, 2018: Ophthalmic Plastic and Reconstructive Surgery
Yabo Huang, Zhong Wang, Qingdong Han
RATIONALE: Tumor resection and extracranial-intracranial bypass concerning medial sphenoid ridge meningioma associated with severe stenosis of the internal carotid artery (ICA) of intracranial segments has been rarely presented. Effective treatment as to the complex lesions may be complicated. Tumor resection and cerebrovascular protection should be both taken into consideration. PATIENT CONCERNS: We presented one case of medial sphenoid ridge meningioma associated with severe stenosis of the internal carotid artery of intracranial segments...
June 2018: Medicine (Baltimore)
Jiaqi Li, Huiwen Tan, Juan Huang, Dan Luo, Ying Tang, Ruichao Yu, Hui Huang
RATIONALE: Thyrotropin-secreting adenoma (TSHoma) is rare. Even though the thyrotoxicosis is mild in patients with TSHoma, it is still a rare cause of arrhythmia, ignore of mild disfunction of thyroid function of TSHoma can lead to the delayed diagnosis of pituitary tumor or leading to recurring of complications. Graves' disease is an auto-immue endocrinological disorder. Association of TSHoma and Graves's disease is extremely rare. Coexistence of these two diseases made the diagnosis and treatment complicated...
June 2018: Medicine (Baltimore)
Ji Hye Hwang, Hyo Won Jung, Seok Yong Kang, An Na Kang, Jun Nan Ma, Xiang Long Meng, Min Sub Hwang, Yong-Ki Park
Acupuncture with MOK, a polyherbal medicine (MOK pharmacopuncture), has been used for the treatment of thyroid syndromes including hypothyroidism and hyperthyroidism in traditional Korean medicine. The present study investigated the effect of MOK pharmacopuncture on hypothyroidism and the mechanism underlying its antioxidation and immune regulation effects. Hypothyroidism was induced in Sprague-Dawley rats by subcutaneous injection of Propylthiouracil (PTU; 10 mg/kg) once daily for 4 weeks. MOK was administered by acupuncture on the acupoints around the thyroid gland of PTU-induced hypothyroidism rats once daily for 2 weeks following hypothyroidism induction...
July 2018: Experimental and Therapeutic Medicine
Silvia Santos Palacios, María Llavero Valero, Antonio Brugos-Larumbe, Juan José Díez, Francisco Guillén-Grima, Juan C Galofré
CONTEXT: To study the prevalence of thyroid dysfunction in a very large unselected population. OBJECTIVE: To determine the prevalence of abnormal thyroid function and evaluate potential modulatory factors. DESIGN AND SETTING: The Estudio de Atención Primaria de Navarra, The APNA Study, is a cross-sectional study conducted in northern Spain. It involved 303,883 people, of 20 years of age and older, who live in the Navarra region. Participants are covered by the public healthcare system and medical records are digitalized...
June 12, 2018: Clinical Endocrinology
Karine Gauthier
The ability of thyroid hormone T3 to stimulate energy expenditure and regulate different aspects of whole body metabolism has been recognized for over a 100 years. Indeed in 1895 Adolf Magnus Levy was already describing the influence of the thyroid on setting the basal metabolic rate. Now it has been well characterized that the level of circulating T3 is correlated with energy expenditure both in humans and in rodent models (Mullur et al., Physiol Rev 94:355-382, 2014; Silva, Thyroid 5:481-492, 1995). Hypothyroidism and hyperthyroidism are respectively associated with low and high energy expenditure leading to high and low body mass index...
2018: Methods in Molecular Biology
Javier García Callejo, Jaume Redondo Martínez, Miguel Civera, José Verdú Colomina, Verónica Pellicer Zoghbi, M Paz Martínez Beneyto
BACKGROUND: Thyroid abscess or acute suppurative thyroiditis is an unusual clinical condition. We present our experience with cases attended over 41 years. MATERIALS AND METHODS: A retrospective study was performed on these patients reviewing their epidemiological characteristics and the diagnostic and therapeutic manoeuvres chosen for them all, as well as their clinical outcome. A group of 9 males and 5 females was studied, with ages ranging from 19 to 68 (mean of 40...
June 8, 2018: Acta Otorrinolaringológica Española
Faheem Shehjar, Dil Afroze, Raiz A Misgar, Sajad A Malik, Bashir A Laway
Graves' disease is a multifactorial autoimmune disorder of the thyroid gland, with some extra-thyroidal complications like eye and skin abnormalities in some patients. GD is more prevalent in women than men and is the leading cause of hyperthyroidism worldwide. A complex interaction between genetic and environmental factors is the proposed cause which triggers immune system to produce autoantibodies stimulating the TSH receptor, leading to clinical manifestations such as hyperthyroidism, diffuse thyroid enlargement (goiter) and often ophthalmopathy in affected individuals...
June 8, 2018: Gene
Erum Rasheed, Jansen Seheult, James Gibney, Gerard Boran
Thyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism where increased influx of potassium into skeletal muscle cells leads to profound hypokalaemia and paralysis. Most cases arise sporadically in Asians however it is being increasingly reported in Caucasians. TPP is regarded as a channelopathy where a genetic and/or acquired defect in the sodium-potassium (Na+/K+-ATPase) pump renders it more sensitive to excess thyroid hormone in susceptible individuals. Because the clinical presentation is similar to familial hypokalaemic periodic paralysis (FHPP), genes implicated in this autosomal dominant condition became candidates for TPP, particularly if they were known to have thyroid hormone-responsive elements...
January 1, 2018: Annals of Clinical Biochemistry
Mengmeng Zhi, Zhenghua Hou, Qiong We, Yuqun Zhang, Ling Li, Yonggui Yuan
Hyperthyroid patients undergo emotional and cognitive dysfunction. However, the neurological basis for it remains ambiguous. Amplitude of low frequency fluctuation (ALFF) and regional homogeneity (ReHo) were used to investigate abnormal spontaneous activity in hyperthyroidism for the first time. 29 hyperthyroid patients and 29 healthy controls (HC) received 3.0T magnetic resonance imaging (MRI) scans and neuropsychological assessments. Compared with HC, hyperthyroid patients showed decreased ALFF in left medial frontal gyrus (MeFG) and left posterior cingulate cortex (PCC)...
June 7, 2018: Behavioural Brain Research
Deep Shah, Nida Khalid
This is a case of a young 34-year-old man who had symptomatic hyperthyroidism from an extremely high serum beta HCG level in the setting of a metastatic stage IIIC mixed germ cell tumour. The patient's thyroid function normalised with treatment of the cancer as the beta HCG levels declined.
June 8, 2018: BMJ Case Reports
Kosuke Inoue, Angela M Leung, Takehiro Sugiyama, Tetsuro Tsujimoto, Noriko Makita, Masaomi Nangaku, Beate R Ritz
BACKGROUND: Iodine deficiency has long been recognized as an important public health problem. Global approaches such as salt iodization that aim to overcome iodine deficiency have been successful. Meanwhile, they have led to excessive iodine consumption in some populations, thereby increasing the risks of iodine-induced thyroid dysfunction, as well as the comorbidities and mortality associated with hypothyroidism and hyperthyroidism. We aimed to elucidate whether iodine intake is associated with mortality among U...
June 8, 2018: Thyroid: Official Journal of the American Thyroid Association
Essi Ryodi, Saara Metso, Heini Huhtala, Matti Välimäki, Anssi Auvinen, Pia Jaatinen
BACKGROUND Hyperthyroid patients remain at an increased risk of cardiovascular diseases (CVDs) after restoring euthyroidism. The impact of the different treatment modalities of hyperthyroidism on future CVD risk remains unclear. The aim of this paper is to assess cardiovascular morbidity and mortality in hyperthyroidism before and after the treatment, and to compare the effects of two different treatment modalities, radioactive iodine (RAI) and thyroid surgery. METHODS A comparative cohort study was conducted among 6,148 hyperthyroid patients treated either with RAI or thyroidectomy, and 18,432 age- and gender-matched controls...
June 8, 2018: Thyroid: Official Journal of the American Thyroid Association
Roghayeh Pakdel, Saeed Niazmand, Mohsen Mouhebati, Mohammad Mahdi Vahedi, Azita Aghaee, Mousa-Al-Reza Hadjzadeh
Objective: The aim of the present study was to compare the effects of Portulaca oleracea (Po) seeds extract and those of valsartan on cardiac function in levothyroxine (T4 )-treated rats. Materials and Methods: Forty Wistar rats were divided into four groups (n=10): control, levothyroxine (T4 ), T4 plus valsartan (T4 -Val) and T4 plus hydro-alcoholic extract of the P. oleracea seeds (T4 -Po). Control group received normal saline. Levothyroxine (100µg/kg/day, i...
May 2018: Avicenna Journal of Phytomedicine
Yetunde Ajoke Onimode, David Magbagbeola Dairo, Annare Ellmann
Introduction: Typically hyperthyroidism has been more often associated with the female gender. There is a large female predilection (male:female sex ratio up to 1:10), with little documentation in the literature about wholly male hyperthyroid populations. A male incidence of 0.7 per 100, 000 has been reported for South African men while the women have a relatively higher rate of 0.02. There is no documented evidence between male and female genders in response to treatment of PH with radioactive iodine (RAI), although operational evidence suggests that hyperthyroidism in males is less amenable to RAI treatment (RAIT) than females...
2018: Pan African Medical Journal
V F Koehler, M Reincke, C Spitzweg
The diagnosis of hypothyroidism is primarily based on clinical signs and symptoms as well as measurement of thyroid-stimulating hormone (TSH) concentration. Subclinical hypothyroidism is characterized by elevated TSH with normal serum free thyroxine (fT4 ) and triiodothyronine (fT3 ) levels, while in manifest hypothyroidism serum fT4 and fT3 levels are reduced. Common causes of primary hypothyroidism are autoimmune thyroiditis as well as therapeutic interventions, such as thyroid surgery or radioiodine therapy...
June 5, 2018: Der Internist
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