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https://www.readbyqxmd.com/read/29708742/modelling-kinase-inhibition-using-highly-confident-data-sets
#1
Sorin Avram, Alina Bora, Liliana Halip, Ramona Curpan
Protein kinases form a consistent class of promising drug targets, and several efforts have been made to predict the activity of small-molecules against a representative part of the kinome. This study continues our previous work (Bora, A.; Avram, S.; Ciucanu, I.; Raica, M.; Avram, S., Predictive Models for Fast and Effective Profiling of Kinase Inhibitors. J. Chem. Inf. MODEL: 2016, 56, 895-905; www.chembioinf.ro), aiming to build and measure the performance of ligand-based kinase inhibitor prediction models...
April 30, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29602311/cardiomyocyte-targeted-and-17%C3%AE-estradiol-loaded-acoustic-nanoprobes-as-a-theranostic-platform-for-cardiac-hypertrophy
#2
Xueli Zhao, Wen Luo, Jing Hu, Lei Zuo, Jing Wang, Rui Hu, Bo Wang, Lei Xu, Jing Li, Meng Wu, Pan Li, Liwen Liu
BACKGROUND: Theranostic perfluorocarbon nanoprobes have recently attracted attention due to their fascinating versatility in integrating diagnostics and therapeutics into a single system. Furthermore, although 17β-estradiol (E2) is a potential anti-hypertrophic drug, it has severe non-specific adverse effects in various organs. Therefore, we have developed cardiomyocyte-targeted theranostic nanoprobes to achieve concurrent targeted imaging and treatment of cardiac hypertrophy. RESULTS: We had successfully synthesized E2-loaded, primary cardiomyocyte (PCM) specific peptide-conjugated nanoprobes with perfluorocarbon (PFP) as a core (PCM-E2/PFPs) and demonstrated their stability and homogeneity...
March 30, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29601217/the-effect-of-patellar-taping-on-lower-extremity-running-kinematics-in-individuals-with-patellofemoral-pain-syndrome
#3
Ariel Pelletier, Paolo Sanzo, Derek Kivi, Carlos Zerpa
PURPOSE: To investigate the effects of patellar taping (Leukotape® (LT), Pinetown, South Africa, Kinesio Tape (KT), Dortmund, Germany, or no tape) on lower extremity kinematics in runners with and without patellofemoral pain syndrome (PFPS). METHODS: In total, 20 healthy individuals and 12 with PFPS ran on a treadmill under different taping conditions and lower extremity kinematics and stride characteristics were obtained using Peak Motus Software, Colorado, USA...
March 30, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29564075/patellofemoral-pain-syndrome-in-female-athletes-a-review-of-diagnoses-etiology-and-treatment-options
#4
Molly Vora, Emily Curry, Amanda Chipman, Elizabeth Matzkin, Xinning Li
Patellofemoral pain syndrome (PFPS) is one of the most common causes of knee pain and is present in females disproportionately more relative to males. PFPS causes tend to be multifactorial in nature and are described in this review. From a review of the current literature, it is clear that there needs to be further research on PFPS in order to better understand the complex etiology of this disorder in both males and females. It is known that females with patellofemoral pain syndrome demonstrate a decrease in abduction, external rotation and extension strength of the affected side compared with healthy patients...
December 14, 2017: Orthopedic Reviews
https://www.readbyqxmd.com/read/29547032/characteristics-of-plantar-pressures-and-related-pain-profiles-in-elite-sprinters-and-recreational-runners
#5
Tong-Hsien Chow, Yih-Shyuan Chen, Jia-Chang Wang
BACKGROUND: Plantar pressure measurement is effective for assessing plantar loading and can be applied to evaluating foot performance. We sought to explore the characteristics of plantar pressures in elite sprinters and recreational runners during static standing and walking. METHODS: Arch index (AI) values, regional plantar pressure distributions (PPDs), and footprint characteristics were examined in 80 elite sprinters and 90 recreational runners using an optical plantar pressure measurement system...
January 2018: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29545683/the-effect-of-aroma-stimulation-during-isotonic-exercise-on-the-rating-of-perceived-exertion-and-blood-fatigue-factors-of-athletes-with-patellofemoral-pain-syndrome
#6
Sangsoo Kim, JongHoo Choo, Sungbum Ju
[Purpose] The purpose of this study is to examine the effect of aroma stimulation during isotonic exercise on the rating of perceived exertion (RPE) and the blood fatigue factors of athletes who have patellofemoral pain syndrome (PFPS). [Subjects and Methods] The research subjects were seven athletes in their twenties who suffer from PFPS. They were divided into a control group and an aroma stimulation group and performed isotonic exercises repeatedly. After exercising, the RPE and blood fatigue factors, including creatine phosphokinase (CPK), lactate dehydrogenase (LDH), and ammonia, were measured through blood sampling...
February 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29519163/ultrasonography-and-clinical-examination-of-knee-injuries-in-pre-and-post-menarche-dancers
#7
Nili Steinberg, Myriam Stern, Shay Tenenbaum, Alexander Blankstein, Aviva Zeev, Itzhak Siev-Ner
This study aimed at evaluating whether the prevalence of knee injuries and morphological features are different among pre-and-post menarche dancers; Sixty-seven pre-and-post menarche dancers were screened for anthropometric parameters; knee laxity; patella femoral pain syndrome (PFPS), pathologies and anatomical structure of the knees. Both groups showed a high and similar prevalence of PFPS. The post-menarche dancers produced a significantly higher rate of Tanner stages 3-4 (p = .010), greater weight (p < ...
March 8, 2018: Research in Sports Medicine
https://www.readbyqxmd.com/read/29424164/-research-progress-on-the-etiology-and-treatment-of-patellofemoral-pain-syndrome
#8
REVIEW
Li-Hua Cui
Patellofemoral pain syndrome (PFPS) is one of the most common diseases that cause pain in the knee joint. At present, there is no specific diagnostic measure. The diagnosis of patellofemoral pain syndrome may be considered when imaging is performed without cartilage, ligament and soft tissue injuries. The etiology includes abnormalities of the patellar motion caused by various anatomical abnormalities, such as abnormal patellar position, increased Q angle, and excessive valgus foot. Dysfunction of the lower extremity muscles such as the imbalance of the four biceps and the dysfunction of the gluteal muscles also play an important role in the development of patellofemoral pain syndrome...
July 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29303366/current-clinical-radiological-and-treatment-perspectives-of-patellofemoral-pain-syndrome
#9
Aishwarya Gulati, Christopher McElrath, Vibhor Wadhwa, Jay P Shah, Avneesh Chhabra
Anterior knee pain in active young adults is commonly related to patellofemoral pain syndrome, which can be broadly classified into patellar malalignment and patellar maltracking. Imaging is performed to further elucidate the exact malalignment and maltracking abnormalities and exclude other differentials. This article details the role of the stabilizers of the patellofemoral joint, findings on conventional and multimodality imaging aiding in patellofemoral pain syndrome diagnosis and characterization, and current perspectives of various treatment approaches...
January 22, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29152104/a-developed-model-of-cancer-patients-participation-in-intravenous-chemotherapy-safety
#10
Zeng Na, Yan Qiaoyuan, Wang Binghan, Zhu Qin, Chen Yue, Peng Xin, Tan Cuilian, Yao Cheng
How to reduce intravenous chemotherapy-related adverse reactions of cancer patients is one focus of clinical work. Nowadays, patient for patient safety (PFPS) is an important component of hospital safety management and can contribute to a reduction in the rate of adverse events following intravenous chemotherapy of cancer patients. To guide and evaluate cancer patients participate in intravenous chemotherapy, we explored a scientific and practical model of cancer patients participation in intravenous chemotherapy safety...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133185/squatting-re-education-with-lumbo-pelvic-thigh-muscle-cocontraction-improves-functional-performance-in-patellofemoral-pain-syndrome-a-case-presentation
#11
Nagarajan Manickaraj
Anterior knee pain, with or without joint crepitus during squatting, is the common clinical feature in the individuals with patellofemoral pain syndrome (PFPS). Altered lower extremity alignment and lumbo-pelvic-thigh muscles motor control is often associated with PFPS. Although current interventions recommend individual muscle activation and strength training exercises, the reported benefits of cocontraction-based exercises in PFPS is limited. This might be due to the long-standing hypothesis that exercise-induced cocontraction of thigh muscles may induce a negative effect by increasing the joint contact forces in individuals with knee osteoarthritis...
November 10, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29120261/effects-of-vision-and-cognitive-load-on-static-postural-control-in-subjects-with-and-without-patellofemoral-pain-syndrome
#12
Afsaneh Zeinalzadeh, Saeed Talebian, Soofia Naghdi, Mahyar Salavati, Salman Nazary-Moghadam, Bahareh Zeynalzadeh Ghoochani
OBJECTIVE: To compare the effects of vision and cognitive load on static postural control in subjects with and without patellofemoral pain syndrome (PFPS). METHODS: Twenty-eight PFPS patients and 28 controls participated in the study. Postural control was assessed in isolation as well as with visual manipulation and cognitive loading on symptomatic limb. The outcome measures of postural control were quantified in terms of area, anterior-posterior (AP), medial-lateral (ML), and mean velocity (MV) of the displacements of center of pressure (COP)...
April 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29071243/pulsed-field-profile-diversities-of-salmonella-enteritidis-s-infantis-and-s-corvallis-in-japan
#13
Koichi Murakami, Tamie Noda, Daisuke Onozuka, Hirokazu Kimura, Shuji Fujimoto
The diversity of pulsed-field profiles (PFPs) within non-typhoidal Salmonella subtypes influences epidemiological analyses of Salmonella outbreaks. Therefore, determining the PFP diversity of each Salmonella serovar is important when evaluating current circulating strains. This study examined the PFP diversity of three important public health Salmonella enterica subspecies enterica serovars, S . Enteritidis (n=177), S . Infantis (n=205), and S . Corvallis (n=90), using pulsed-field gel electrophoresis. Isolates were collected from several sources, primarily from chicken-derived samples, in the Kyushu-Okinawa region of Japan between 1989 and 2005...
August 16, 2017: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/29037636/effects-of-kinesio-taping-%C3%A2-on-knee-function-and-pain-in-athletes-with-patellofemoral-pain-syndrome
#14
Elaheh Aghapour, Fahimeh Kamali, Ehsan Sinaei
OBJECTIVE: To compare the knee performance and pain in athletes with patellofemoral pain syndrome (PFPS) before and after applying Kinesio Tape® (KT) on vastus medialis obliquus (VMO) muscle. PARTICIPANTS: Fifteen participants (10 females, five males) with unilateral PFPS were examined and compared under taped and untaped conditions. INTERVENTION: VMO of the involved leg was taped from origin to insertion, with 75% of KT's maximal length tension...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29037624/does-leg-predomination-affect-measuring-vasti-muscle-onsets-during-single-leg-squatting-a-reliability-study
#15
Javid Mostamand, Dan L Bader, Zoë Hudson
INTRODUCTION: Although measuring vasti muscle onset may reveal whether pain relief is associated with altering this parameter during activities in subjects with patellofemoral pain syndrome (PFPS), it may be necessary to determine whether the inherent properties of the dominant leg influences the reliability of measuring VMO-VL muscle onset. The aim of the present study was to examine the effect of leg predomination on reliability testing of the VMO-VL muscle onset measurement during single leg squatting in healthy subjects...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28952850/sex-specific-relationships-between-hip-strength-and-hip-pelvis-and-trunk-kinematics-in-healthy-runners
#16
James J Hannigan, Louis R Osternig, Li-Shan Chou
Weak hip muscle strength and excessive hip motion during running have been suggested as potential risk factors for developing patellofemoral pain syndrome (PFPS) in females, but not males. There is conflicting evidence on the relationship between hip strength and hip kinematics, which may be partly due to sex differences in the relationship between these parameters. Hip, pelvis, and trunk kinematics were collected while 60 healthy, habitual runners (23 females, 37 males) ran overground, and isometric hip abduction and external rotation strengths were measured bilaterally...
February 1, 2018: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28821517/quality-differences-between-private-for-profit-private-non-profit-and-public-hospitals-in-norway-a-retrospective-national-register-based-study-of-acute-readmission-rates-following-total-hip-and-knee-arthroplasties
#17
Geir Hiller Holom, Terje P Hagen
OBJECTIVES: To compare the quality of care-using unplanned acute hospital readmissions as a quality measure-among patients treated at private for-profit hospitals (PFPs), private non-profit hospitals (PNPs) and public hospitals (PUBs) in Norway. DESIGN: A retrospective comparative study using the Norwegian Patient Register. Readmissions were evaluated by logistic regressions both using adjustment for various patient-level and other covariates, and a two-stage model using distance as an instrumental variable...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28750964/comparison-of-ischemic-compression-and-lumbopelvic-manipulation-as-trigger-point-therapy-for-patellofemoral-pain-syndrome-in-young-adults-a-double-blind-randomized-clinical-trial
#18
Shabnam Behrangrad, Fahimeh Kamali
OBJECTIVE: To compare the effectiveness of ischemic compression (IC) directly to the vastus medialis obliquus (VMO) versus lumbopelvic manipulation (LPM) in improving pain, functional status and sensitivity to mechanical stimulation of the VMO trigger point in patients with patellofemoral pain syndrome (PFPS). PARTICIPANTS: 40 patients with unilateral PFPS aged 20-30 years were selected randomly among patients with unilateral PFPS referred to physical therapy clinics of Shiraz University of Medical Sciences in Shiraz, Iran, between March 2014 and July 2014...
July 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28652829/patellofemoral-pain-in-athletes
#19
REVIEW
Wolf Petersen, Ingo Rembitzki, Christian Liebau
Patellofemoral pain (PFP) is a frequent cause of anterior knee pain in athletes, which affects patients with and without structural patellofemoral joint (PFJ) damage. Most younger patients do not have any structural changes to the PFJ, such as an increased Q angle and a cartilage damage. This clinical entity is known as patellofemoral pain syndrome (PFPS). Older patients usually present with signs of patellofemoral osteoarthritis (PFOA). A key factor in PFPS development is dynamic valgus of the lower extremity, which leads to lateral patellar maltracking...
2017: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/28617653/systematic-review-of-the-effect-of-taping-techniques-on-patellofemoral-pain-syndrome
#20
REVIEW
Catherine A Logan, Abhiram R Bhashyam, Ashley J Tisosky, Daniel B Haber, Anna Jorgensen, Adam Roy, Matthew T Provencher
CONTEXT: Taping is commonly used in the management of several musculoskeletal conditions, including patellofemoral pain syndrome (PFPS). Specific guidelines for taping are unknown. OBJECTIVE: To investigate the efficacy of knee taping in the management of PFPS. Our hypothesis was that tension taping and exercise would be superior to placebo taping and exercise as well as to exercise or taping alone. DATA SOURCES: The PubMed/MEDLINE, Cochrane, Rehabilitation and Sports Medicine Source, and CINAHL databases were reviewed for English-language randomized controlled trials (RCTs) evaluating the efficacy of various taping techniques that were published between 1995 and April 2015...
September 2017: Sports Health
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