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https://www.readbyqxmd.com/read/28315426/vascular-patterning-in-human-heterotopic-ossification
#1
Margaret Cocks, Aditya Mohan, Carolyn A Meyers, Catherine Ding, Benjamin Levi, Edward McCarthy, Aaron W James
Heterotopic ossification (HO, also termed myositis ossificans) is the formation of extra-skeletal bone in muscle and soft tissues. HO is a tissue repair process gone awry, and is a common complication of surgery and traumatic injury. Medical strategies to prevent and treat HO fall well short of addressing the clinical need. Better characterization of the tissues supporting HO is critical to identifying therapies directed against this common and sometimes devastating condition. The physiologic processes of osteogenesis and angiogenesis are highly coupled and interdependent...
March 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28293462/heterotopic-ossification-myositis-ossificans-progressiva-a-condition-interfering-with-rheumatic-disease
#2
Gülşen Işıklı, Lütfi Akyol, Sibel Semirgin Uçak, Kerim Aslan, Metin Özgen, Mehmet Sayarlıoğlu
No abstract text is available yet for this article.
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28275867/myositis-ossificans-in-children-a-review
#3
N K Sferopoulos, R Kotakidou, A S Petropoulos
The formation of lamellar bone in the soft tissues, where bone normally does not exist, is called myositis ossificans. However, it would be more accurate to describe as myositis ossificans the involvement of skeletal muscles and as ectopic or heterotopic ossification the involvement of soft tissues in general. The lesion is subdivided in genetic and non-genetic or acquired types. Myositis or fibrodysplasia ossificans progressiva is a debilitating rare genetic disorder. Clinical suspicion of the disease in the newborn on the basis of malformed great toes may lead to early clinical diagnosis, confirmatory diagnostic genetic testing and avoidance of iatrogenic harmful procedures...
March 9, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28273711/-progressive-myositis-ossificans-a-case-report
#4
(no author information available yet)
No abstract text is available yet for this article.
March 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28117081/post-traumatic-forearm-nonunion-in-healthy-skeletally-immature-children-a-report-on-15-cases
#5
Giovanni Luigi Di Gennaro, Stefano Stilli, Giovanni Trisolino
BACKGROUND: Nonunion is a rare but severe complication following forearm fracture in skeletally immature patients. The purpose of this study is to describe a case series of pediatric forearm nonunions treated at our Institute. MATERIALS AND METHOD: We retrospectively reviewed medical charts and radiographs of healthy children affected by post-traumatic nonunion of the forearm, from April 1992 to July 2015. An overall series of 15 cases was included in the study...
January 9, 2017: Injury
https://www.readbyqxmd.com/read/28115283/the-rare-bone-disease-working-group-report-from-the-2016-american-society-for-bone-and-mineral-research-annual-meeting
#6
Matthew T Drake, Michael T Collins, Edward C Hsiao
A working group on rare bone diseases was held in Atlanta, Georgia as part of the 2016 annual meeting of the American Society for Bone and Mineral Research. The meeting was organized by Matthew Drake. Given recent advances in our understanding of fibrodysplasia ossificans progressiva (FOP), the initial portion of the program was devoted to basic, translational, and clinical aspects of FOP. The remainder of the program was divided into updates on an array of rare bone diseases as detailed below. In total, there were more than 120 scientists from academia and industry in attendance...
January 20, 2017: Bone
https://www.readbyqxmd.com/read/27989444/analog-method-for-radiographic-assessment-of-heterotopic-bone-in-fibrodysplasia-ossificans-progressiva
#7
Chamith S Rajapakse, Carter Lindborg, Haitao Wang, Benjamin T Newman, Elizabeth A Kobe, Gregory Chang, Eileen M Shore, Frederick S Kaplan, Robert J Pignolo
RATIONALE AND OBJECTIVES: Severe progressive multifocal heterotopic ossification (HO) is a rare occurrence seen predominantly in patients who have fibrodysplasia ossificans progressiva (FOP) and is difficult to quantitate owing to patient-, disease-, logistical-, and radiation-related issues. The purpose of this study was to develop and validate a scoring system based on plain radiographs for quantitative assessment of HO lesions in patients with FOP. MATERIALS AND METHODS: Institutional review board approval was obtained from the University of Pennsylvania, and all data comply with Health Insurance Portability and Accountability Act regulations...
March 2017: Academic Radiology
https://www.readbyqxmd.com/read/27942591/mtor-inhibition-and-bmp-signaling-act-synergistically-to-reduce-muscle-fibrosis-and-improve-myofiber-regeneration
#8
Shailesh Agarwal, David Cholok, Shawn Loder, John Li, Christopher Breuler, Michael T Chung, Hsiao Hsin Sung, Kavitha Ranganathan, Joe Habbouche, James Drake, Joshua Peterson, Caitlin Priest, Shuli Li, Yuji Mishina, Benjamin Levi
Muscle trauma is highly morbid due to intramuscular scarring, or fibrosis, and muscle atrophy. Studies have shown that bone morphogenetic proteins (BMPs) reduce muscle atrophy. However, increased BMP signaling at muscle injury sites causes heterotopic ossification, as seen in patients with fibrodysplasia ossificans progressiva (FOP), or patients with surgically placed BMP implants for bone healing. We use a genetic mouse model of hyperactive BMP signaling to show the development of intramuscular fibrosis surrounding areas of ectopic bone following muscle injury...
December 8, 2016: JCI Insight
https://www.readbyqxmd.com/read/27935932/early-recognition-of-fibrodysplasia-ossificans-progressiva-important-for-the-clinician
#9
A Singh, G Pradhan, C Kumari, S Kapoor
Fibrodysplasia ossificans progressiva is a rare disorder of heterotopic ossification. Procedures like biopsy and surgery are known to be aggravating factors in promoting heterotopic ossification Clues to clinical diagnosis may therefore be a great advantage to treating orthopedician. Valgus deformity of great toe is an important diagnostic clue for treating physicians and thus aids in preventing the clinicians from subjecting the patients to unnecessary invasive and traumatic procedures. Hence clinical clues to early diagnosis are important in establishing the correct diagnosis and directing future management...
April 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27908413/trace-element-and-cytokine-concentrations-in-patients-with-fibrodysplasia-ossificans-progressiva-fop-a-case-control-study
#10
Laura Hildebrand, Timo Gaber, Peter Kühnen, Rolf Morhart, Heinz Unterbörsch, Lutz Schomburg, Petra Seemann
Fibrodysplasia Ossificans Progressiva (FOP) is a rare inherited disease characterized by progressive heterotopic ossification. Disease onset, severity and symptoms vary between FOP patients, as does the frequency and activity of so-called flare-ups, during which tendons, ligaments, muscle and soft tissue are replaced by bone. Traumata, infections or other stressors are known inducers of flare-ups, and the hormone Activin A may be involved in disease activity; however, reliable biomarkers for FOP activity are missing, and the basal trace element and inflammatory state of patients are unknown...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27887014/intra-abdominal-myositis-ossificans-in-an-asymptomatic-patient-during-closure-of-a-hartmann-s-colostomy
#11
Georgios Sahsamanis, Panagiotis Triantafylakis, Konstantinos Gkouzis, Konstantinos Katis, Georgios Dimitrakopoulos
Intra-abdominal myositis ossificans, also known as heterotopic mesenteric ossification, defines the formation of bone-like lesions inside the abdominal cavity. It is a rare medical condition, usually following abdominal surgery or trauma. A 55-year-old male presented for closure of a Hartmann's colostomy, created 6 months ago because of sigmoid adenocarcinoma. Intraoperative findings consisted of an elongated bone-like lesion attached on the peritoneum and protruding inside the abdominal cavity, while two more stiff calcified nodules were found in the mesocolon...
November 24, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27881824/two-tissue-resident-progenitor-lineages-drive-distinct-phenotypes-of-heterotopic-ossification
#12
Devaveena Dey, Jana Bagarova, Sarah J Hatsell, Kelli A Armstrong, Lily Huang, Joerg Ermann, Ashley J Vonner, Yue Shen, Agustin H Mohedas, Arthur Lee, Elisabeth M W Eekhoff, Annelies van Schie, Marie B Demay, Charles Keller, Amy J Wagers, Aris N Economides, Paul B Yu
Fibrodysplasia ossificans progressiva (FOP), a congenital heterotopic ossification (HO) syndrome caused by gain-of-function mutations of bone morphogenetic protein (BMP) type I receptor ACVR1, manifests with progressive ossification of skeletal muscles, tendons, ligaments, and joints. In this disease, HO can occur in discrete flares, often triggered by injury or inflammation, or may progress incrementally without identified triggers. Mice harboring an Acvr1(R206H) knock-in allele recapitulate the phenotypic spectrum of FOP, including injury-responsive intramuscular HO and spontaneous articular, tendon, and ligament ossification...
November 23, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27881797/deterioration-of-vestibular-cells-in-labyrinthitis
#13
Serdar Kaya, Patricia A Schachern, Vladimir Tsuprun, Michael M Paparella, Sebahattin Cureoglu
OBJECTIVE: To quantitatively assess the effect of serous labyrinthitis, suppurative labyrinthitis, and labyrinthitis ossificans on vestibular hair cells, dark cells, and transitional cells. METHODS: We examined human temporal bone specimens with serous labyrinthitis, suppurative labyrinthitis, and labyrinthitis ossificans, then compared them with age-matched control groups without labyrinthitis. We evaluated the density of type I and II vestibular hair cells, dark cells, and transitional cells in the peripheral sensorial organs...
February 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27867996/towards-a-cure-for-fibrodysplasia-ossificans-progressiva
#14
EDITORIAL
Gonzalo Sanchez-Duffhues, David J J de Gorter, Peter Ten Dijke
No abstract text is available yet for this article.
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27800117/myositis-ossificans-progressive-case-report
#15
Sofia Talbi, Nassira Aradoini, Iman El Mezouar, Fatima Ezzahra Abourazzak, Taoufik Harzy
Myositis ossificans progressiva (MOP) is an autosomal dominant disorder. There is a progressive ectopic ossification and skeletal malformation, mainly in the connective tissue of muscle. The diagnosis is based on the clinical findings and radiological demonstration of the skeletal malformations. A 38-year-old female patient was admitted to our department with progressive increase of the thigh. Results of laboratory studies were normal. The radiography of the right thigh showed multiple intramuscular calcifications...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27794120/bmp-smad-id-promotes-reprogramming-to-pluripotency-by-inhibiting-p16-ink4a-dependent-senescence
#16
Yohei Hayashi, Edward C Hsiao, Salma Sami, Mariselle Lancero, Christopher R Schlieve, Trieu Nguyen, Koyori Yano, Ayako Nagahashi, Makoto Ikeya, Yoshihisa Matsumoto, Ken Nishimura, Aya Fukuda, Koji Hisatake, Kiichiro Tomoda, Isao Asaka, Junya Toguchida, Bruce R Conklin, Shinya Yamanaka
Fibrodysplasia ossificans progressiva (FOP) patients carry a missense mutation in ACVR1 [617G > A (R206H)] that leads to hyperactivation of BMP-SMAD signaling. Contrary to a previous study, here we show that FOP fibroblasts showed an increased efficiency of induced pluripotent stem cell (iPSC) generation. This positive effect was attenuated by inhibitors of BMP-SMAD signaling (Dorsomorphin or LDN1931890) or transducing inhibitory SMADs (SMAD6 or SMAD7). In normal fibroblasts, the efficiency of iPSC generation was enhanced by transducing mutant ACVR1 (617G > A) or SMAD1 or adding BMP4 protein at early times during the reprogramming...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27756329/pre-surgical-ct-assessment-of-neurogenic-myositis-ossificans-of-the-hip-and-risk-factors-of-recurrence-a-series-of-101-consecutive-patients
#17
Bruno Law-Ye, Chloé Hangard, Adrien Felter, Dominique Safa, Philippe Denormandie, François Genet, Robert-Yves Carlier
BACKGROUND: Neurogenic Myositis Ossificans (NMO) is a rare disabling pathology characterized by peri-articular heterotopic ossifications following severe peripheral or central nervous system injuries. It results in ankylosis and vessels or nerves compressions. Our study aimed to describe the pre-operative findings of patients with NMO of the hip using biphasic computerized tomography (CT). METHODS: Between 2006 and 2012, we retrospectively analyzed 101 consecutive patients with hip NMO...
October 18, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27713089/the-fibrodysplasia-ossificans-progressiva-fop-mutation-p-r206h-in-acvr1-confers-an-altered-ligand-response
#18
Laura Hildebrand, Katja Stange, Alexandra Deichsel, Manfred Gossen, Petra Seemann
Patients with Fibrodysplasia Ossificans Progressiva (FOP) suffer from ectopic bone formation, which progresses during life and results in dramatic movement restrictions. Cause of the disease are point mutations in the Activin A receptor type 1 (ACVR1), with p.R206H being most common. In this study we compared the signalling responses of ACVR1(WT) and ACVR1(R206H) to different ligands. ACVR1(WT), but not ACVR1(R206H) inhibited BMP signalling of BMP2 or BMP4 in a ligand binding domain independent manner. Likewise, the basal BMP signalling activity of the receptor BMPR1A or BMPR1B was inhibited by ACVR1(WT), but enhanced by ACVR1(R206H)...
January 2017: Cellular Signalling
https://www.readbyqxmd.com/read/27691970/myositis-ossificans-traumatica-in-a-vampire-bat-desmodus-rotundus
#19
Jennifer C Hausmann, Jorden Manasse, Sarah Churgin, Howard Steinberg, Victoria L Clyde, Roberta Wallace
A 15-yr-old sexually intact female vampire bat ( Desmodus rotundus ) was diagnosed with myositis ossificans traumatica of the abdominal wall. The bat presented with a large ulcerated firm mass along the abdomen. Radiographs and cytology were performed, followed by surgical exploration. The mass was determined to be nonresectable and the bat was euthanized. Histopathology showed severe necrotizing, degenerative, and pyogranulomatous myositis with osseous and cartilaginous metaplasia, fibrosis, and ulceration, which were consistent with myositis ossificans traumatica...
September 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27672859/poster-92-identifying-nonhereditary-myositis-ossificans-traumaticus-in-a-community-hospital
#20
Quoc P Tran, Kannan Thanikachalam
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
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