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https://www.readbyqxmd.com/read/28107238/roles-of-the-endoplasmic-reticulum-stress-transducer-oasis-in-ossification-of-the-posterior-longitudinal-ligament
#1
Yu Chen, Haisong Yang, Jinhao Miao, Xiaowei Liu, Xinwei Wang, Deyu Chen
STUDY DESIGN: In vitro molecular research on the posterior longitudinal ligament fibroblasts. OBJECTIVE: To investigate different expression of old astrocyte specifically induced substance (OASIS) between spinal ligament fibroblasts from the patients with ossification of the posterior longitudinal ligament (OPLL) and from non-OPLL patients and demonstrate knockdown of OASIS protein expression by RNA interference inhibiting expression of type I collagen (COL I) in OPLL cells...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28107236/surgical-technique-for-decompression-of-severe-thoracic-myelopathy-due-to-tuberous-ossification-of-ligamentum-flavum
#2
Ting Wang, Chuqiang Yin, Dechun Wang, Shuzhong Li, Xiaoliang Chen
STUDY DESIGN: Retrospective review. OBJECTIVE: To describe a safe surgical procedure, en bloc resection of the posterior wall of the thoracic canal, for the decompression of severe thoracic myelopathy caused by tuberous ossification of the ligamentum flavum (OLF). SUMMARY OF BACKGROUND DATA: OLF has been widely recognized as a cause of thoracic myelopathy in East Asia. Surgical decompression of thoracic myelopathy caused by OLF is technically demanding...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28107070/tracheal-collapse-in-a-pekin-duck-anas-platyrhynchos-domestica
#3
Eugénie Henry-Guyot, Isabelle Langlois, Isabelle Lanthier, Dipl Acvp
A 5-year-old, 3.72-kg female Pekin duck ( Anas platyrhynchos domestica) was presented for acute respiratory distress, head shaking, and collapse. Similar spontaneously resolving episodes had previously occurred. Physical examination revealed severe inspiratory and expiratory dyspnea. Due to poor prognosis, euthanasia was elected. Postmortem examination revealed severe tracheal collapse involving the proximal trachea. The tracheal lumen was reduced in size by 75%. Histologic evaluation revealed ossification of the tracheal rings for approximately 60%-100% of their circumference...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28106675/treatment-of-slipped-capital-femoral-epiphysis-with-the-modified-dunn-procedure-a-multicenter-study
#4
Masquijo J Javier, Allende Victoria, D'Elia Martín, Miranda Gabriela, Fernández Claudio A
INTRODUCTION: Treatment of moderate to severe slipped capital femoral epiphysis (SCFE) is controversial. Over the last years, 3 institutions in Argentina adopted the modified Dunn procedure for capital realignment in selected cases of SCFE. Our aim in this study was to evaluate the clinical outcome and the rate of complications of patients who had undergone surgical hip dislocation and capital realignment. METHODS: A multicenter retrospective cohort study of patients who received the modified Dunn procedure from January 2009 to 2013 was performed...
January 18, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28104945/neonatal-and-infantile-spinal-sonography-a-useful-investigation-often-underutilized
#5
Nikhil Nair, M Sreenivas, Arun K Gupta, Devasenathipathy Kandasamy, Manisha Jana
Sonography is an ideal, effective, noninvasive tool for evaluation of the spinal cord in neonatal and early infantile age groups owing to lack of ossification of the posterior elements of spine. Understanding normal anatomical appearances is a prerequisite for the interpretation of various pathologies of the spinal canal and its contents. This review elucidates normal appearances of the spinal cord in this age group, in both axial and sagittal planes. Usefulness of Doppler sonography is briefly discussed, and special emphasis is placed on normal anatomical variants that may mimic spinal abnormalities...
October 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28104095/application-of-distal-radius-positioned-hinged-external-fixator-in-complete-open-release-for-severe-elbow-stiffness
#6
Yi Zhou, Jiang-Yu Cai, Shuai Chen, Shen Liu, Wei Wang, Cun-Yi Fan
BACKGROUND: Radical release for severe stiff elbows may lead to instability. Hinged external fixation is used to treat unstable elbows. We hypothesized that extensive open release combined with a distal radius-positioned hinged external fixator would have good performance and low complications rate in treating severe elbow stiffness. Thus, the efficacy and security of this technique were assessed in this study. METHODS: We retrospectively reviewed 38 post-traumatic elbows with severe stiffness that underwent arthrolysis between February 2011 and February 2014...
February 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28104092/the-use-of-indomethacin-in-the-prevention-of-postoperative-radioulnar-synostosis-after-distal-biceps-repair
#7
Callista L Costopoulos, Joseph A Abboud, Matthew L Ramsey, Charles L Getz, Daniel S Sholder, John P Taras, Daniel Huttman, Mark D Lazarus
BACKGROUND: This study evaluated the incidence of symptomatic radioulnar synostosis/heterotopic ossification after distal biceps tendon repair in patients receiving indomethacin prophylaxis. We hypothesized that indomethacin use postoperatively would decrease the occurrence of symptomatic synostosis. METHODS: A single-center retrospective record review identified 124 patients undergoing distal biceps repair between 2011 and 2014. Patients were analyzed for administration of indomethacin, contraindications to administration, age, time to surgery, fixation method, medical comorbidities, and development of symptomatic synostosis...
February 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28103899/intraoperative-evaluation-using-mobile-computed-tomography-in-anterior-cervical-decompression-with-floating-method-for-massive-ossification-of-the-posterior-longitudinal-ligament
#8
Toshitaka Yoshii, Takashi Hirai, Tsuyoshi Yamada, Hiroyuki Inose, Tsuyoshi Kato, Kenichiro Sakai, Mitsuhiro Enomoto, Shigenori Kawabata, Yoshiyasu Arai, Atsushi Okawa
BACKGROUND: An anterior decompression and fusion (ADF) with the floating method is an effective procedure for treating ossification of the posterior longitudinal ligament (OPLL), allowing a direct decompressive effect on the spinal cord. However, the procedure is skill-intensive, particularly in cases of OPLL with a high canal-occupying ratio. In such cases, there are potential risks for insufficient decompression due to the incomplete floating of the OPLL. Here, we introduce an anterior decompression procedure for massive OPLL, using an intraoperative computed tomography (CT) with a mobile scanner gantry for the intraoperative evaluation of the decompression...
January 19, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28102164/results-of-total-cementless-hip-joint-arthroplasty-with-taperloc-stem
#9
Marek Drobniewski, Andrzej Borowski, Magdalena Krasińska, Marcin Sibiński, Marek Synder
BACKGROUND: The aim of this paper is to present the results of hip joint arthroplasty with the use of the Taperloc stem. MATERIAL AND METHODS: The study group consisted of 117 patients (75 women and 42 men) who underwent 121 hip joint arthroplasties with Taperloc stems. Mean age of the patients at surgery was 53.8 years (range: 2475 years). Mean follow-up period was 159.5 months. RESULTS: Pre-operative Merle d'Aubigne-Postel scores (modified by Charnley) of the study group were poor in all patients...
August 30, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28102155/surgical-treatment-of-radial-head-fractures-outcomes-and-complications
#10
Bartosz Chwedczuk, Piotr Piekarczyk, Krzysztof Kwiatkowski, Krzysztof Piątkowski
BACKGROUND: Appropriate treatment of radial head fractures remains an area of disputes and controversy. The present paper aims to assess the outcomes of surgical fixation of these injuries and identify the most common complications. MATERIAL AND METHODS: The medical records of 63 patients (25 women and 38 men) treated in 2011 -2014 were analysed retrospectively. The treatment outcomes were assessed according to the Broberg and Morrey rating system and the QuickDASH score...
October 28, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28100862/-bone-flap-resorption-after-cranioplasty-in-pediatric-patients-report-of-2-cases
#11
Rintaro Yokoyama, Takeshi Mikami, Shouhei Noshiro, Kei Miyata, Kentaro Toyama, Katsuya Komatsu, Noriaki Kikuchi, Tadashi Hasegawa, Nobuhiro Mikuni
Aseptic bone flap resorption, a rare complication after cranioplasty following decompressive craniectomy, is more likely to develop in children. We experienced two cases of aseptic bone flap resorption and identified potential pathophysiological mechanisms through histological findings. In the first case, an 11-year-old girl underwent decompressive craniectomy due to brain swelling with contusion. An autologous bone flap was cryopreserved for four months. Twenty-five months after cranioplasty with autologous bone flap, aseptic bone flap resorption was observed, and cranioplasty was performed with ceramic bone...
January 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28100407/pressure-ulcer-reconstruction-in-patients-with-heterotopic-ossification-after-spinal-cord-injury-a-case-series-and-review-of-literature
#12
REVIEW
Kai Yang, Alexander Graf, James Sanger
Heterotopic ossification (HO) is widely recognized as a common occurrence among patients suffering from traumatic spinal cord injuries (SCI). The exact etiology of HO formation remains unknown. Published medical and surgical management strategies are often plagued with questionable effectiveness and frequent complications. There are minimal publications regarding the management strategies of HO in SCI patients as it pertains to plastic surgery. We present a case series of patients treated at our institution who underwent treatment for pressure ulcers with underlying HO to highlight the vast spectrum of clinical phenotypes present in this population...
December 21, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28099350/retrospective-observational-study-comparing-the-international-hip-dysplasia-institute-classification-with-the-tonnis-classification-of-developmental-dysplasia-of-the-hip
#13
Mingyuan Miao, Haiqing Cai, Liwei Hu, Zhigang Wang
The Tonnis radiographic classification of developmental dysplasia of the hip (DDH) has been widely used. The International Hip Dysplasia Institute (IHDI) classification, a new classification system recently developed by the IHDI, is beginning to be applied to evaluate DDH with the absence of an ossification center. This study aimed to validate its reliability in evaluating DDH with an ossification center and compared the 2 classifications in evaluating all DDH hips. In addition, the prediction values of the 2 classifications on clinical management selection were compared...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28099187/a-comparative-study-of-anterior-decompression-with-fusion-and-posterior-decompression-with-laminoplasty-for-the-treatment-of-cervical-spondylotic-myelopathy-patients-with-large-anterior-compression-of-the-spinal-cord
#14
Takashi Hirai, Toshitaka Yoshii, Yoshiyasu Arai, Kenichiro Sakai, Ichiro Torigoe, Hidetsugu Maehara, Masaki Tomori, Takashi Taniyama, Hirokazu Sato, Atsushi Okawa
STUDY DESIGN: This is a retrospective observational single-center study. OBJECTIVES: To compare anterior decompression and fusion (ADF) and laminoplasty (LAMP) for the treatment of cervical spondylotic myelopathy (CSM) patients with large anterior compression in terms of clinical and radiologic outcomes. SUMMARY OF BACKGROUND DATA: We have reported that insufficient posterior decompression could be often seen after laminoplasty for CSM patients with preoperative anterior clearance of the spinal cord, defined as an interval <4 mm between the preoperative the modified K-line and anterior structure of the spinal canal at most compressive segment on sagittal T1-weighted magnetic resonance imaging...
January 17, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28098705/heterotopic-ossification-in-acetabular-fracture-surgery
#15
Reza Firoozabadi, Timothy Alton, Henry Claude Sagi
Heterotopic ossification (HO) is a common complication of the surgical treatment of acetabular fractures. HO is the formation of trabecular bone in soft tissues where bone does not usually occur. Over the last decade, many risk factors have been identified for HO after surgical fixation of acetabular fractures; however, prophylaxis and treatment of this condition are controversial. Potential preventive measures range from NSAIDs to external beam irradiation, but recent studies have questioned the utility of these measures...
February 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28097257/heterotopic-ossification-and-clinical-outcome-in-nonconstrained-cervical-arthroplasty
#16
EDITORIAL
Sung Bae Park, Young Jun Jin, Ki-Jeong Kim
No abstract text is available yet for this article.
December 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28097087/identification-of-the-vascular-endothelial-growth-factor-signalling-pathway-by-quantitative-proteomic-analysis-of-rat-condylar-cartilage
#17
Liting Jiang, Yinyin Xie, Li Wei, Qi Zhou, Xing Shen, Xinquan Jiang, Yiming Gao
Angiogenesis mediated by vascular endothelial growth factor (VEGF) is known to play an important role in regulating cartilage remodelling and endochondral ossification. However, the details of how VEGF signalling mechanisms affect condyle remodelling in response to alterations in functional loading remains unclear. To explore this, eighty 16-day-old male SD rats were divided into two equal groups which were fed either a soft/powdery diet or a hard diet for 4 weeks; the stiffness of the diet results in alteration of mastication force and hence temporomandibular joint (TMJ) development...
January 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28096214/cartilage-to-bone-transformation-during-fracture-healing-is-coordinated-by-the-invading-vasculature-and-induction-of-the-core-pluripotency-genes
#18
Diane P Hu, Federico Ferro, Frank Yang, Aaron J Taylor, Wenhan Chang, Theodore Miclau, Ralph S Marcucio, Chelsea S Bahney
Fractures heal predominantly through the process of endochondral ossification. The classic model of endochondral ossification holds that chondrocytes mature to hypertrophy, undergo apoptosis and new bone forms by invading osteoprogenitors. However, recent data demonstrate that chondrocytes transdifferentiate to osteoblasts in the growth plate and during regeneration, yet the mechanism(s) regulating this process remain unknown. Here, we show a spatially-dependent phenotypic overlap between hypertrophic chondrocytes and osteoblasts at the chondro-osseous border in the fracture callus, in a region we define as the transition zone (TZ)...
January 15, 2017: Development
https://www.readbyqxmd.com/read/28092213/cellular-and-molecular-factors-influencing-tendon-repair
#19
Sushmitha Durgam, Matthew Stewart
Tendons are complex, hierarchically organized connective tissues that transmit tensile forces between muscles and tendons. Tendon injuries are among the most common orthopedic problems with long-term disability as a frequent consequence due to prolonged healing time. Further, the repair tissue is of inferior quality, predisposing patients to high rates of recurrence following initial injury. Co-ordinated cellular processes and biological factors under the influence of mechanical loading are involved in tendon healing and our understanding of these events lags behind other musculoskeletal tissues...
January 16, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28081584/-mini-open-approach-shows-good-results-in-treatment-of-femoroacetabular-impingement
#20
Stephanie Maria Kirschbaum, Frank Sitterlee, Carsten Perka, Michael Müller
Background Femoroacetabular impingement (FAI) describes a painful, abnormal (bony) contact between the femoral neck and acetabulum, which, if left untreated, contributes to early osteoarthritis (OA) of the hip. Despite its flat learning curve and long operation times, hip arthroscopy has been used increasingly often in recent years in the surgery of femoroacetabular impingement. The mini-open technique (MOT) offers a possible alternative that addresses the abnormal morphological prominence and allows minimally invasive clearance of hip motion...
January 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
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