keyword
MENU ▼
Read by QxMD icon Read
search

ossification

keyword
https://www.readbyqxmd.com/read/29656627/ossification-of-the-posterior-longitudinal-ligament-in-cervical-spine-prevalence-management-and-prognosis
#1
REVIEW
Jau-Ching Wu, Yu-Chun Chen, Wen-Cheng Huang
Ossification of the posterior longitudinal ligament (OPLL) in the cervical spine and related neurological complications are not uncommon in East Asian countries. The estimated prevalence of cervical OPLL-related hospitalization is 7.7 per 100,000 person-years in Taiwan, and higher incidence rates have been observed in elderly and male patients. Although cervical OPLL is frequently insidious, it can eventually cause myelopathy and predispose patients to spinal cord injury (SCI). There are multiple options for managing cervical OPLL, ranging from observation to many kinds of surgical procedures, including posterior laminoplasty, laminectomy with or without fusion, anterior corpectomy with or without instrumentation, and circumferential decompression and fusion...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29655901/in-vivo-heterotopic-culturing-of-prefabricated-tendon-grafts-with-mechanical-stimulation-in-a-sheep-model
#2
M Petri, P Lu, M Omar, M Ettinger, C Krettek, C Neunaber, M Jagodzinski
BACKGROUND: The goal of this study is to investigate the biomechanical and histological properties of in vivo heterotopically prefabricated cruciate ligament replacement grafts with and without mechanical stimulation. The clinical goal is to heterotopically prefabricate a bone-tendon-bone graft for anterior cruciate ligament reconstruction, which allows rapid ingrowth and early full weight bearing. METHODS: In a sheep model, eight quadriceps tendon grafts were harvested and introduced into culture chambers at their proximal and distal ends...
April 11, 2018: Knee
https://www.readbyqxmd.com/read/29652785/clinical-prediction-rule-for-heterotopic-ossification-of-the-hip-in-patients-with-spinal-cord-injury
#3
Eduardo M Suero, Mustafa Citak
STUDY DESIGN: Case-control study; clinical prediction rule. OBJECTIVE: To construct and internally validate a clinical prediction rule to identify patients at high risk of developing heterotopic ossification (HO) after spinal cord injury (SCI). SUMMARY OF BACKGROUND DATA: HO after SCI can lead to loss of joint mobility, loss of function, peripheral nerve entrapment, and pressure sores. HO is usually diagnosed based on clinical symptoms, as no laboratory tests are yet available to identify patients with early HO formation...
April 12, 2018: Spine
https://www.readbyqxmd.com/read/29649650/assessment-of-myelopathy-in-cervical-ossification-of-the-posterior-longitudinal-ligament-by-mri-assisted-3d-measurement
#4
Zhiwei Wang, Yanqing Sun, Yifan Tang, Bo Yuan, Shengyuan Zhou, Xiongsheng Chen, Lianshun Jia
OBJECTIVE: Ossification of the posterior longitudinal ligament (OPLL) is a three-dimensional (3D) disease that causes cervical myelopathy. The conventional two-dimensional(2D) measurement of OPLL has limitations in estimating cord-compression and myelopathy. In this study, we attempted to use three-dimensional computed tomography(3D CT) and magnetic resonance imaging(MRI) to measure the 3D occupying ratio of OPLL and investigate its significance in assessment of spinal cord myelopathy...
April 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29644115/shp2-regulates-skeletal-cell-fate-by-modifying-sox9-expression-and-transcriptional-activity
#5
Chunlin Zuo, Lijun Wang, Raghavendra M Kamalesh, Margot E Bowen, Douglas C Moore, Mark S Dooner, Anthony M Reginato, Qian Wu, Christoph Schorl, Yueming Song, Matthew L Warman, Benjamin G Neel, Michael G Ehrlich, Wentian Yang
Chondrocytes and osteoblasts differentiate from a common mesenchymal precursor, the osteochondroprogenitor (OCP), and help build the vertebrate skeleton. The signaling pathways that control lineage commitment for OCPs are incompletely understood. We asked whether the ubiquitously expressed protein-tyrosine phosphatase SHP2 (encoded by Ptpn11 ) affects skeletal lineage commitment by conditionally deleting Ptpn11 in mouse limb and head mesenchyme using "Cre-loxP"-mediated gene excision. SHP2-deficient mice have increased cartilage mass and deficient ossification, suggesting that SHP2-deficient OCPs become chondrocytes and not osteoblasts...
2018: Bone Research
https://www.readbyqxmd.com/read/29643813/skull-development-ossification-pattern-and-adult-shape-in-the-emerging-lizard-model-organism-pogona-vitticeps-a-comparative-analysis-with-other-squamates
#6
Joni Ollonen, Filipe O Da Silva, Kristin Mahlow, Nicolas Di-Poï
The rise of the Evo-Devo field and the development of multidisciplinary research tools at various levels of biological organization have led to a growing interest in researching for new non-model organisms. Squamates (lizards and snakes) are particularly important for understanding fundamental questions about the evolution of vertebrates because of their high diversity and evolutionary innovations and adaptations that portrait a striking body plan change that reached its extreme in snakes. Yet, little is known about the intricate connection between phenotype and genotype in squamates, partly due to limited developmental knowledge and incomplete characterization of embryonic development...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29643689/the-utility-of-tc-99m-hydroxymethylene-diphosphonate-single-photon-emission-computed-tomography-computed-tomography-in-symptomatic-os-trigonum
#7
Sharjeel Usmani, Noora Bin Essa, Fahad Marafi, Rashid Rasheed, Fareeda Al Kandari
Os trigonum is a congenital condition in which a bone ossicle fails to fuse to a secondary ossification center in the posterior aspect of the talar bone. Repetitive plantar flexion of the foot may elicit inflammation of the ossicles fibrous connective band, subsequently causing pain. It is common to misdiagnose os trigonum as an avulsion fracture. We report a case of a 23-year-old male with symptomatic os trigonum diagnosed on Tc-99m hydroxymethylene diphosphonate single-photon emission computed tomography-computed tomography (SPECT-CT)...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29643138/improvement-of-thoracic-myelopathy-following-bariatric-surgery-in-an-obese-patient
#8
Shota Takenaka, Yoshihiro Mukai, Noboru Hosono, Takashi Kaito
Revision spine surgery is extremely challenging in super-super obese patients (body mass index (BMI) ≥60 kg/m2 ). This is the first report describing how bariatric surgery was useful for a super-super obese patient with progressing myelopathy. A 44-year-old man with a BMI of 62.9 kg/m2 presented with an ambulatory disorder caused by thoracic ossification of the posterior longitudinal ligament (T7-8). Before this paraparesis, he had undergone four spinal operations, and was not considered a good candidate for a fifth spine surgery...
April 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29627275/growth-impairment-in-mucopolysaccharidoses
#9
REVIEW
Melodie Melbouci, Robert W Mason, Yasuyuki Suzuki, Toshiyuki Fukao, Tadao Orii, Shunji Tomatsu
Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders that affect regulation of glycosaminoglycan (GAG) processing. In MPS, the lysosomes cannot efficiently break down GAGs, and the specific GAGs accumulated depend on the type of MPS. The level of impairment of breakdown varies between patients, making this one of the many factors that lead to a range of clinical presentations even in the same type of MPS. These clinical presentations usually involve skeletal dysplasia, in which the most common feature is bone growth impairment and successive short stature...
March 16, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29626545/hypoxia-selective-allosteric-destabilization-of-activin-receptor-like-kinases-a-potential-therapeutic-avenue-for-prophylaxis-of-heterotopic-ossification
#10
Guorong Lu, Mary R Tandang-Silvas, Alyssa C Dawson, Trenton J Dawson, Jay C Groppe
Heterotopic ossification (HO), the pathological extraskeletal formation of bone, can arise from blast injuries, severe burns, orthopedic procedures and gain-of-function mutations in a component of the bone morphogenetic protein (BMP) signaling pathway, the ACVR1/ALK2 receptor serine-threonine (protein) kinase, causative of Fibrodysplasia Ossificans Progressiva (FOP). All three ALKs (-2, -3, -6) that play roles in bone morphogenesis contribute to trauma-induced HO, hence are well-validated pharmacological targets...
April 4, 2018: Bone
https://www.readbyqxmd.com/read/29625813/sidus-stem-free-shoulder-system-for-primary-osteoarthritis-short-term-results-of-a-multicenter-study
#11
Anna Krukenberg, Julie McBirnie, Stefan Bartsch, Nikolaus Böhler, Ernst Wiedemann, Bernhard Jost, Pierre Mansat, Pierre Bellon-Champel, Renzo Angeloni, Markus Scheibel
BACKGROUND: The aim of this prospective multicenter study was to evaluate clinical and radiologic results of a new metaphyseal anchored system. This system features a different anchor geometry that potentially leads to better bony integration and less loosening. METHODS: From November 2012 until December 2015, 148 patients (151 shoulders) were treated with the Sidus Stem-Free Shoulder System at 9 centers in Europe. The main indication was primary osteoarthritis (80...
April 3, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29624608/intramembranous-bone-formation-after-callus-distraction-is-augmented-by-increasing-axial-compressive-strain
#12
Julian Schuelke, Nicholaus Meyers, Sandra Reitmaier, Svenja Klose, Anita Ignatius, Lutz Claes
The mechanical environment is a primary factor in the success of distraction osteogenesis. It is known that the interfragmentary movement during the distraction and maturation phase effects the callus formation. In addition to cyclic compression, other movements like shear and bending influence the bone formation process as shown in previous callus distraction studies. Reports of cartilage presence and endochondral ossification in the regenerative zone have been associated with a lack of fixation stability and delayed healing...
2018: PloS One
https://www.readbyqxmd.com/read/29621987/distribution-of-ossified-spinal-lesions-in-patients-with-severe-ossification-of-the-posterior-longitudinal-ligament-and-prediction-of-ossification-at-each-segment-based-on-the-cervical-op-index-classification-a-multicenter-study-josl-ct-study
#13
Takashi Hirai, Toshitaka Yoshii, Narihito Nagoshi, Kazuhiro Takeuchi, Kanji Mori, Shuta Ushio, Akio Iwanami, Tsuyoshi Yamada, Shoji Seki, Takashi Tsuji, Kanehiro Fujiyoshi, Mitsuru Furukawa, Soraya Nishimura, Kanichiro Wada, Takeo Furuya, Yukihiro Matsuyama, Tomohiko Hasegawa, Katsushi Takeshita, Atsushi Kimura, Masahiko Abematsu, Hirotaka Haro, Tetsuro Ohba, Masahiko Watanabe, Hiroyuki Katoh, Kei Watanabe, Hiroshi Ozawa, Haruo Kanno, Shiro Imagama, Kei Ando, Shunsuke Fujibayashi, Masao Koda, Masashi Yamazaki, Morio Matsumoto, Masaya Nakamura, Atsushi Okawa, Yoshiharu Kawaguchi
BACKGROUND: In patients with ossification of the posterior longitudinal ligament (OPLL) in the cervical spine, it is well known that the thoracic ossified lesions often coexist with the cervical lesions and can cause severe myelopathy. However, the prevalence of OPLL at each level of the thoracic and lumbar spinal segments is unknown. The aims of this study were to investigate how often OPLL occurs at each level in the thoracolumbar spine in patients with a radiological diagnosis of cervical OPLL and to identify the spinal levels most likely to develop ossification...
April 5, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29621984/management-of-isolated-coronal-shear-fractures-of-the-humeral-capitellum-with-herbert-screw-fixation-through-anterolateral-approach
#14
Tengbo Yu, Hao Tao, Fenglei Xu, Yanling Hu, Chengdong Zhang, Guangjie Zhou
BACKGROUND: Due to the intraarticular and complex nature of the coronal shear fracture of the humeral capitellum and its rarity, it has been difficult to formulate a universally accepted method of surgical management. The purpose of this study is to retrospectively evaluate the clinical outcomes of 15 patients with isolated coronal shear fractures of the capitellum treated by Herbert screw fixation through anterolateral approach, and to address the safety and tips for this surgical procedure...
April 5, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29619368/the-chondro-osseous-continuum-is-it-possible-to-unlock-the-potential-assigned-within
#15
REVIEW
Behzad Javaheri, Soraia P Caetano-Silva, Ioannis Kanakis, George Bou-Gharios, Andrew A Pitsillides
Endochondral ossification (EO), by which long bones of the axial skeleton form, is a tightly regulated process involving chondrocyte maturation with successive stages of proliferation, maturation, and hypertrophy, accompanied by cartilage matrix synthesis, calcification, and angiogenesis, followed by osteoblast-mediated ossification. This developmental sequence reappears during fracture repair and in osteoarthritic etiopathology. These similarities suggest that EO, and the cells involved, are of great clinical importance for bone regeneration as it could provide novel targeted approaches to increase specific signaling to promote fracture healing, and if regulated appropriately in the treatment of osteoarthritis...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29618652/the-metalloproteinase-proteoglycans-adamts7-and-adamts12-provide-an-innate-tendon-specific-protective-mechanism-against-heterotopic-ossification
#16
Timothy J Mead, Daniel R McCulloch, Jason C Ho, Yaoyao Du, Sheila M Adams, David E Birk, Suneel S Apte
Heterotopic ossification (HO) is a significant clinical problem with incompletely resolved mechanisms. Here, the secreted metalloproteinases ADAMTS7 and ADAMTS12 are shown to comprise a unique proteoglycan class that protects against a tendency toward HO in mouse hindlimb tendons, menisci, and ligaments. Adamts7 and Adamts12 mRNAs were sparsely expressed in murine forelimbs but strongly coexpressed in hindlimb tendons, skeletal muscle, ligaments, and meniscal fibrocartilage. Adamts7-/- Adamts12-/- mice, but not corresponding single-gene mutants, which demonstrated compensatory upregulation of the intact homolog mRNA, developed progressive HO in these tissues after 4 months of age...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29616218/recent-insights-into-the-contribution-of-the-changing-hypertrophic-chondrocyte-phenotype-in-the-development-and-progression-of-osteoarthritis
#17
REVIEW
Ellen G J Ripmeester, Ufuk Tan Timur, Marjolein M J Caron, Tim J M Welting
Osteoarthritis (OA) is an extremely prevalent age-related condition. The economic and societal burden due to the cost of symptomatic treatment, inability to work, joint replacement, and rehabilitation is huge and increasing. Currently, there are no effective medical therapies that delay or reverse the pathological manifestations of OA. Current treatment options are, without exception, focused on slowing down progression of the disease to postpone total joint replacement surgery for as long as possible and keeping the associated pain and joint immobility manageable...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29615017/clinical-and-radiographic-outcome-of-dynamic-cervical-implant-dci-arthroplasty-for-degenerative-cervical-disc-disease-a-minimal-five-year-follow-up
#18
Lin-Nan Wang, Bo-Wen Hu, Lei Wang, Yue-Ming Song, Xi Yang, Li-Min Liu, Hao Liu
BACKGROUND: To evaluate the mid- to long-term clinical and radiographic outcomes of anterior cervical discectomy and dynamic cervical implant (DCI) arthroplasty for degenerative cervical disc disease. METHODS: From April 2010 to October 2010, 38 patients with single- or double-level cervical disc herniation underwent anterior cervical discectomy and DCI arthroplasty. The clinical results and radiographic outcomes of these 38 patients (42 levels) were retrospectively evaluated...
April 4, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29614433/acquired-and-congenital-forms-of-heterotopic-ossification-new-pathogenic-insights-and-therapeutic-opportunities
#19
REVIEW
Maurizio Pacifici
Heterotopic ossification (HO) involves the formation and accumulation of extraskeletal bone tissue at the expense of local tissues including muscles and connective tissues. There are common forms of HO that are triggered by extensive trauma, burns and other bodily insults, and there are also rare congenital severe forms of HO that occur in children with Fibrodysplasia Ossificans Progressiva or Progressive Osseous Heteroplasia. Given that HO is often preceded by inflammation, current treatments usually involve anti-inflammatory drugs alone or in combination with local irradiation, but are not very effective...
March 31, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29610705/osteology-of-batrachuperus-londongensis-urodela-hynobiidae-study-of-bony-anatomy-of-a-facultatively-neotenic-salamander-from-mount-emei-sichuan-province-china
#20
Jian-Ping Jiang, Jia Jia, Meihua Zhang, Ke-Qin Gao
The Longdong Stream Salamander Batrachuperus londongensis , living in a mountain stream environment at Mt. Emei in Sichuan Province, China, represents a rare species that is facultatively neotenic in the family Hynobiidae. Although the species has been known to science for some 40 years since its initial discovery in the late 1970s, anatomical details of its osteology remain poorly understood and developmental information is still lacking for the species. This study (1) provides a detailed osteological account of B...
2018: PeerJ
keyword
keyword
41315
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"