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CKD pediatrics guidelines

Oleh M Akchurin, Amy J Kogon, Juhi Kumar, Christine B Sethna, Hoda T Hammad, Paul J Christos, John D Mahan, Larry A Greenbaum, Robert Woroniecki
BACKGROUND: Growth impairment remains common in children with chronic kidney disease (CKD). Available literature indicates low level of recombinant human growth hormone (rhGH) utilization in short children with CKD. Despite efforts at consensus guidelines, lack of high-level evidence continues to complicate rhGH therapy decision-making and the level of practice variability in rhGH treatment by pediatric nephrologists is unknown. METHODS: Cross-sectional online survey electronically distributed to pediatric nephrologists through the Midwest Pediatric Nephrology Consortium and American Society of Pediatric Nephrology...
May 30, 2017: BMC Nephrology
Christopher S Almond, Helena Hoen, Joseph W Rossano, Chesney Castleberry, Scott R Auerbach, Lingyao Yang, Ashwin K Lal, Melanie D Everitt, Matthew Fenton, Seth A Hollander, Elfriede Pahl, Elizabeth Pruitt, David N Rosenthal, Doff B McElhinney, Kevin P Daly, Manisha Desai
BACKGROUND: There is inadequate power to perform a valid clinical trial in pediatric heart transplantation (HT) using a conventional end-point, because the disease is rare and hard end-points, such as death or graft loss, are infrequent. We sought to develop and validate a surrogate end-point involving the cumulative burden of post-transplant complications to predict death/graft loss to power a randomized clinical trial of maintenance immunosuppression in pediatric HT. METHODS: Pediatric Heart Transplant Study (PHTS) data were used to identify all children who underwent an isolated orthotopic HT between 2005 and 2014 who survived to 6 months post-HT...
April 2018: Journal of Heart and Lung Transplantation
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
Kelly R McMahon, Shahrad Rod Rassekh, Kirk R Schultz, Maury Pinsk, Tom Blydt-Hansen, Cherry Mammen, Ross T Tsuyuki, Prasad Devarajan, Geoff D E Cuvelier, Lesley G Mitchell, Sylvain Baruchel, Ana Palijan, Bruce C Carleton, Colin J D Ross, Michael Zappitelli
BACKGROUND: Childhood cancer survivors experience adverse drug events leading to lifelong health issues. The Applying Biomarkers to Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) team was established to validate and apply biomarkers of cancer treatment effects, with a goal of identifying children at high risk of developing cancer treatment complications associated with thrombosis, graft-versus-host disease, hearing loss, and kidney damage. Cisplatin is a chemotherapy well known to cause acute and chronic nephrotoxicity...
2017: Canadian Journal of Kidney Health and Disease
Wen Chen, Kirstie Ducharme-Smith, Laura Davis, Wun Fung Hui, Bradley A Warady, Susan L Furth, Alison G Abraham, Aisha Betoko
BACKGROUND: Our purpose was to identify the main food contributors to energy and nutrient intake in children with chronic kidney disease (CKD). METHODS: In this cross-sectional study of dietary intake assessed using Food Frequency Questionnaires (FFQ) in the Chronic Kidney Disease in Children (CKiD) cohort study, we estimated energy and nutrient intake and identified the primary contributing foods within this population. RESULTS: Completed FFQs were available for 658 children...
July 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Ashraf Galal, Fatina I Fadel, Enas Mokhtar, Manal F Elshamaa, Eman A Elghoroury, Solaf Kamel, Gamila S M Elsaeed, Eman H Thabet
BACKGROUND AND OBJECTIVES: Data concerning the concentration of matrix metalloproteinase-9 (MMP-9) and its functional polymorphisms in chronic kidney diseases (CKD) are conflicting. The present study aimed to evaluate the levels of MMP-9in children with end stage renal diseases (ESRD) on hemodialysis (HD) and to explore its association with MMP-9 polymorphism and vitamin D levels as an important risk factors for cardiovascular diseases (CVD). METHODS: We studied 55 children with ESRD on hemodialysis and 18 healthy children served as controls...
September 2016: International Journal of Biomedical Science: IJBS
C Pietrement, E Allain-Launay, J Bacchetta, A Bertholet-Thomas, L Dubourg, J Harambat, R Vieux, G Deschênes
These guidelines are intended to assist physicians in the care of children with chronic kidney disease (CKD), defined in children as in adults, regardless of its cause. Often silent for a long time, CKD can evolve to chronic renal failure or end-stage renal disease. Its management aims at slowing disease progression and treating CKD complications as soon as they appear. The different aspects of pediatric CKD care are addressed in these guidelines (screening, treatment, monitoring, diet, quality of life) as proposed by the French Society of Pediatric Nephrology...
November 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Giovanni Montini, Alberto Edefonti, Yajaira Silva Galán, Mabel Sandoval Díaz, Marta Medina Manzanarez, Giuseppina Marra, Fabio Robusto, Gianni Tognoni, Fabio Sereni
BACKGROUND: The widely recognized clinical and epidemiological relevance of the socioeconomic determinants of health-disease conditions is expected to be specifically critical in terms of chronic diseases in fragile populations in low-income countries. However, in the literature, there is a substantial gap between the attention directed towards the medical components of these problems and the actual adoption of strategies aimed at providing solutions for the associated socioeconomic determinants, especially in pediatric populations...
2016: PloS One
Motoshi Hattori, Masayuki Iwano, Mayumi Sako, Masataka Honda, Hirokazu Okada, Yuko Akioka, Akira Ashida, Yukihiko Kawasaki, Hideyasu Kiyomoto, Yoshio Terada, Daishi Hirano, Mikiya Fujieda, Shouichi Fujimoto, Takao Masaki, Shoichi Maruyama, Seiich Mastuo
BACKGROUND: Transition of adolescent and young adult (AYA) patients with childhood-onset chronic kidney diseases (C-CKD) from pediatric to adult renal services has received increasing attention. However, information on transition of Japanese patients with C-CKD is limited. METHODS: The Transition Medicine Working Group, in collaboration with the Japanese Society for Nephrology, the Japanese Society for Pediatric Nephrology and the Japanese Society of Pediatric Urology, conducted a retrospective cross-sectional study in 2014 on issues concerning the transition of Japanese patients with C-CKD...
December 2016: Clinical and Experimental Nephrology
Leah A Krischock, Karlijn J van Stralen, Enrico Verrina, E Jane Tizard, Marjolein Bonthuis, György Reusz, Farida K Hussain, Augustina Jankauskiene, Gregor Novljan, Brankica Spasojević-Dimitrijeva, Ludmila Podracka, Vera Zaller, Kitty J Jager, Franz Schaefer
BACKGROUND: Our aim was to determine the prevalence of sub-target hemoglobin (Hb) levels in children with a renal allograft and to identify potential determinants associated with these Hb levels. METHODS: Data from 3669 children with a functioning renal allograft, aged <18 years between 1 January 2000 and 31 December 2012, from 20 European countries were retrieved from the ESPN/ERA-EDTA Registry, providing 16,170 Hb measurements. RESULTS: According to the NKF/KDOQI classification and the UK-NICE guidelines, 49...
February 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Jesse Jansen, Shannon McKinn, Carissa Bonner, Les Irwig, Jenny Doust, Paul Glasziou, Brooke Nickel, Barbara van Munster, Kirsten McCaffery
BACKGROUND: Clinical care for older adults is complex and represents a growing problem. They are a diverse patient group with varying needs, frequent presence of multiple comorbidities, and are more susceptible to treatment harms. Thus Clinical Practice Guidelines (CPGs) need to carefully consider older adults in order to guide clinicians. We reviewed CPG recommendations for primary cardiovascular disease (CVD) prevention and examined the extent to which CPGs address issues important for older people identified in the literature...
2015: BMC Family Practice
Lourdes Paula R Resontoc, Hui-Kim Yap
Neonatal renal vascular thrombosis is rare but has devastating sequelae. The renal vein is more commonly affected than the renal artery. Most neonates with renal vein thrombosis present with at least one of the three cardinal signs, namely, abdominal mass, macroscopic hematuria and thrombocytopenia, while unilateral renal artery thrombosis presents with transient hypertension. Contrast angiography is the gold standard for diagnosis but because of exposure to radiation and contrast agents, Doppler ultrasound scan is widely used instead...
June 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Janis M Dionne
Hypertension is common in children with chronic kidney disease and early evidence suggests that it is a modifiable risk factor for renal and cardiovascular outcomes. Recommendations for blood pressure management in children with chronic kidney disease can be found in various clinical practice guidelines including the 4th Task Force Report, the European Society of Hypertension pediatric recommendations, and the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI) and Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for the management of blood pressure in chronic kidney disease...
November 2015: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Víctor M García-Nieto, Fernán Fortich, M Isabel Luis-Yanes, Cinzia Tripodi, Pedro Arango-Sancho
BACKGROUND: The G1 stage of chronic kidney disease (CKD) is defined in the 2012 KDIGO Guideline as kidney damage characterized by structural or functional kidney abnormalities without deterioration of glomerular filtration rate. Albuminuria and electrolyte abnormalities due to tubular disorders are considered functional markers of kidney damage. Changes in renal water handling are not explicitly cited in these guidelines. A large sample of children with abnormal dimercaptosuccinic acid (DMSA) scan located in the G1 stage was used in this study...
2015: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Li Fan, Andrew S Levey, Vilmundur Gudnason, Gudny Eiriksdottir, Margret B Andresdottir, Hrefna Gudmundsdottir, Olafur S Indridason, Runolfur Palsson, Gary Mitchell, Lesley A Inker
Current guidelines recommend reporting eGFR using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations unless other equations are more accurate, and recommend the combination of creatinine and cystatin C (eGFRcr-cys) as more accurate than either eGFRcr or eGFRcys alone. However, preferred equations and filtration markers in elderly individuals are debated. In 805 adults enrolled in the community-based Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we measured GFR (mGFR) using plasma clearance of iohexol, standardized creatinine and cystatin C, and eGFR using the CKD-EPI, Japanese, Berlin Initiative Study (BIS), and Caucasian and Asian pediatric and adult subjects (CAPA) equations...
August 2015: Journal of the American Society of Nephrology: JASN
Susan Halbach, Joseph Flynn
Hypertension (HTN) is increasingly recognized as a common feature of pediatric chronic kidney disease (CKD). A growing body of evidence demonstrates that HTN is both underdiagnosed and undertreated in this population. The consequences of untreated HTN include adverse effects on CKD progression, markers of cardiovascular morbidity, and neurocognitive functioning. Consensus guidelines issued over the past decade have incorporated recent research on the consequences of HTN in recommendations for the diagnosis and treatment of HTN in pediatric CKD and include lower BP targets...
January 2015: Current Hypertension Reports
Thomas A Forbes, Alan R Watson, Aleksandra Zurowska, Rukshana Shroff, Sevcan Bakkaloglu, Karel Vondrak, Michel Fischbach, Johan Van de Walle, Gema Ariceta, Alberto Edefonti, Christoph Aufricht, Augustina Jankauskiene, Tuula Holta, Mesiha Ekim, Claus Peter Schmitt, Constantinos Stefanidis
BACKGROUND: There is increasing focus on the problems involved in the transition and transfer of young adult patients from paediatric to adult renal units. This situation was addressed by the 2011 International Pediatric Nephrology Association/International Society of Nephrology (IPNA/ISN) Consensus Statement on transition. METHODS: We performed a survey of transition practices of 15 paediatric nephrology units across Europe 2 years after publication of the consensus statement...
September 2014: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Alaleh Gheissari, Saeedeh Hemmatzadeh, Alireza Merrikhi, Sharareh Fadaei Tehrani, Yahya Madihi
BACKGROUND: Chronic kidney disease (CKD) is an overwhelming illness in children. Considering the importance of CKD in pediatric age group, in addition to the racial and ethnic differences in prevalence and etiology of CKD, epidemiologic studies are recommended. The majority of the results regarding the incidence of CKD have been achieved from studies on hospitalized children. OBJECTIVES: This study evaluates the incidence and etiology of chronic renal failure (CRF) in children in a tertiary care center in Isfahan, the second large province of Iran...
October 2012: Journal of Nephropathology
Adeera Levin, Paul E Stevens
The 2102 KDIGO Guidelines for CKD evaluation, classification, and management have updated the original 2002 KDOQI Guidelines, using newer data and addressing issues raised over the last decade concerning definitions and assessment. This commentary highlights the key aspects of the CKD guidelines, and describes the rationale for specific wording and the scope of the document. A precis of key concepts in each of the five sections of the guideline is presented. The guideline document is intended for general practioners and nephrologists, and covers both adult and pediatric CKD evaluation, classification, and management...
May 29, 2013: Kidney International
Byoung-Soo Cho, Won-Ho Hahn, Hae Il Cheong, Inseok Lim, Cheol Woo Ko, Su-Young Kim, Dae-Yeol Lee, Tae-Sun Ha, Jin-Soon Suh
BACKGROUND: Since 1998, urine screening tests have been performed on school children in Korea. We report the findings of the screening program that analyzed patients with proteinuria and/or hematuria. METHODS: Between 1999 and 2008, 5,114 children were referred to pediatric nephrologists at seven nationwide hospitals. Renal biopsies were performed on 1,478 children [28.79 % of total subjects; 26.77 % for isolated hematuria (IH), 9.09 % for isolated proteinuria (IP), and 51...
April 2013: Clinical and Experimental Nephrology
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