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CKD pediatrics guidelines

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https://www.readbyqxmd.com/read/27829825/matrix-metalloproteinase-mmp-9-levels-in-children-on-hemodialysis-association-with-mmp-9-c-1562-t-gene-polymorphism-and-vitamin-d-levels
#1
Ashraf Galal, Fatina I Fadel, Enas Mokhtar, Manal F Elshamaa, Eman A Elghoroury, Solaf Kamel, Gamila S M Elsaeed, Eman H Thabet
BACKGROUND AND OBJECTIVES: Data concerning the concentration of matrix metalloproteinase-9 (MMP-9) and its functional polymorphisms in chronic kidney diseases (CKD) are conflicting. The present study aimed to evaluate the levels of MMP-9in children with end stage renal diseases (ESRD) on hemodialysis (HD) and to explore its association with MMP-9 polymorphism and vitamin D levels as an important risk factors for cardiovascular diseases (CVD). METHODS: We studied 55 children with ESRD on hemodialysis and 18 healthy children served as controls...
September 2016: International Journal of Biomedical Science: IJBS
https://www.readbyqxmd.com/read/27743765/-diagnosis-and-management-of-chronic-kidney-disease-in-children-guidelines-of-the-french-society-of-pediatric-nephrology
#2
C Pietrement, E Allain-Launay, J Bacchetta, A Bertholet-Thomas, L Dubourg, J Harambat, R Vieux, G Deschênes
These guidelines are intended to assist physicians in the care of children with chronic kidney disease (CKD), defined in children as in adults, regardless of its cause. Often silent for a long time, CKD can evolve to chronic renal failure or end-stage renal disease. Its management aims at slowing disease progression and treating CKD complications as soon as they appear. The different aspects of pediatric CKD care are addressed in these guidelines (screening, treatment, monitoring, diet, quality of life) as proposed by the French Society of Pediatric Nephrology...
October 12, 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27171479/non-medical-risk-factors-as-avoidable-determinants-of-excess-mortality-in-children-with-chronic-kidney-disease-a-prospective-cohort-study-in-nicaragua-a-model-low-income-country
#3
Giovanni Montini, Alberto Edefonti, Yajaira Silva Galán, Mabel Sandoval Díaz, Marta Medina Manzanarez, Giuseppina Marra, Fabio Robusto, Gianni Tognoni, Fabio Sereni
BACKGROUND: The widely recognized clinical and epidemiological relevance of the socioeconomic determinants of health-disease conditions is expected to be specifically critical in terms of chronic diseases in fragile populations in low-income countries. However, in the literature, there is a substantial gap between the attention directed towards the medical components of these problems and the actual adoption of strategies aimed at providing solutions for the associated socioeconomic determinants, especially in pediatric populations...
2016: PloS One
https://www.readbyqxmd.com/read/26780894/transition-of-adolescent-and-young-adult-patients-with-childhood-onset-chronic-kidney-disease-from-pediatric-to-adult-renal-services-a-nationwide-survey-in-japan
#4
Motoshi Hattori, Masayuki Iwano, Mayumi Sako, Masataka Honda, Hirokazu Okada, Yuko Akioka, Akira Ashida, Yukihiko Kawasaki, Hideyasu Kiyomoto, Yoshio Terada, Daishi Hirano, Mikiya Fujieda, Shouichi Fujimoto, Takao Masaki, Shoichi Maruyama, Seiich Mastuo
BACKGROUND: Transition of adolescent and young adult (AYA) patients with childhood-onset chronic kidney diseases (C-CKD) from pediatric to adult renal services has received increasing attention. However, information on transition of Japanese patients with C-CKD is limited. METHODS: The Transition Medicine Working Group, in collaboration with the Japanese Society for Nephrology, the Japanese Society for Pediatric Nephrology and the Japanese Society of Pediatric Urology, conducted a retrospective cross-sectional study in 2014 on issues concerning the transition of Japanese patients with C-CKD...
December 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/26385862/anemia-in-children-following-renal-transplantation-results-from-the-espn-era-edta-registry
#5
Leah A Krischock, Karlijn J van Stralen, Enrico Verrina, E Jane Tizard, Marjolein Bonthuis, György Reusz, Farida K Hussain, Augustina Jankauskiene, Gregor Novljan, Brankica Spasojević-Dimitrijeva, Ludmila Podracka, Vera Zaller, Kitty J Jager, Franz Schaefer
BACKGROUND: Our aim was to determine the prevalence of sub-target hemoglobin (Hb) levels in children with a renal allograft and to identify potential determinants associated with these Hb levels. METHODS: Data from 3669 children with a functioning renal allograft, aged <18 years between 1 January 2000 and 31 December 2012, from 20 European countries were retrieved from the ESPN/ERA-EDTA Registry, providing 16,170 Hb measurements. RESULTS: According to the NKF/KDOQI classification and the UK-NICE guidelines, 49...
February 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/26289559/systematic-review-of-clinical-practice-guidelines-recommendations-about-primary-cardiovascular-disease-prevention-for-older-adults
#6
REVIEW
Jesse Jansen, Shannon McKinn, Carissa Bonner, Les Irwig, Jenny Doust, Paul Glasziou, Brooke Nickel, Barbara van Munster, Kirsten McCaffery
BACKGROUND: Clinical care for older adults is complex and represents a growing problem. They are a diverse patient group with varying needs, frequent presence of multiple comorbidities, and are more susceptible to treatment harms. Thus Clinical Practice Guidelines (CPGs) need to carefully consider older adults in order to guide clinicians. We reviewed CPG recommendations for primary cardiovascular disease (CVD) prevention and examined the extent to which CPGs address issues important for older people identified in the literature...
2015: BMC Family Practice
https://www.readbyqxmd.com/read/26173707/renal-vascular-thrombosis-in-the-newborn
#7
Lourdes Paula R Resontoc, Hui-Kim Yap
Neonatal renal vascular thrombosis is rare but has devastating sequelae. The renal vein is more commonly affected than the renal artery. Most neonates with renal vein thrombosis present with at least one of the three cardinal signs, namely, abdominal mass, macroscopic hematuria and thrombocytopenia, while unilateral renal artery thrombosis presents with transient hypertension. Contrast angiography is the gold standard for diagnosis but because of exposure to radiation and contrast agents, Doppler ultrasound scan is widely used instead...
June 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/25752760/evidence-based-guidelines-for-the-management-of-hypertension-in-children-with-chronic-kidney-disease
#8
REVIEW
Janis M Dionne
Hypertension is common in children with chronic kidney disease and early evidence suggests that it is a modifiable risk factor for renal and cardiovascular outcomes. Recommendations for blood pressure management in children with chronic kidney disease can be found in various clinical practice guidelines including the 4th Task Force Report, the European Society of Hypertension pediatric recommendations, and the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (K/DOQI) and Kidney Disease: Improving Global Outcomes (KDIGO) guidelines for the management of blood pressure in chronic kidney disease...
November 2015: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/25611835/water-renal-management-is-altered-more-frequently-than-albuminuria-in-children-in-the-g1-stage-of-the-2012-kdigo-guideline
#9
Víctor M García-Nieto, Fernán Fortich, M Isabel Luis-Yanes, Cinzia Tripodi, Pedro Arango-Sancho
BACKGROUND: The G1 stage of chronic kidney disease (CKD) is defined in the 2012 KDIGO Guideline as kidney damage characterized by structural or functional kidney abnormalities without deterioration of glomerular filtration rate. Albuminuria and electrolyte abnormalities due to tubular disorders are considered functional markers of kidney damage. Changes in renal water handling are not explicitly cited in these guidelines. A large sample of children with abnormal dimercaptosuccinic acid (DMSA) scan located in the G1 stage was used in this study...
2015: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/25527647/comparing-gfr-estimating-equations-using-cystatin-c-and-creatinine-in-elderly-individuals
#10
COMPARATIVE STUDY
Li Fan, Andrew S Levey, Vilmundur Gudnason, Gudny Eiriksdottir, Margret B Andresdottir, Hrefna Gudmundsdottir, Olafur S Indridason, Runolfur Palsson, Gary Mitchell, Lesley A Inker
Current guidelines recommend reporting eGFR using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations unless other equations are more accurate, and recommend the combination of creatinine and cystatin C (eGFRcr-cys) as more accurate than either eGFRcr or eGFRcys alone. However, preferred equations and filtration markers in elderly individuals are debated. In 805 adults enrolled in the community-based Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we measured GFR (mGFR) using plasma clearance of iohexol, standardized creatinine and cystatin C, and eGFR using the CKD-EPI, Japanese, Berlin Initiative Study (BIS), and Caucasian and Asian pediatric and adult subjects (CAPA) equations...
August 2015: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/25432895/treatment-of-hypertension-in-children-with-chronic-kidney-disease
#11
REVIEW
Susan Halbach, Joseph Flynn
Hypertension (HTN) is increasingly recognized as a common feature of pediatric chronic kidney disease (CKD). A growing body of evidence demonstrates that HTN is both underdiagnosed and undertreated in this population. The consequences of untreated HTN include adverse effects on CKD progression, markers of cardiovascular morbidity, and neurocognitive functioning. Consensus guidelines issued over the past decade have incorporated recent research on the consequences of HTN in recommendations for the diagnosis and treatment of HTN in pediatric CKD and include lower BP targets...
January 2015: Current Hypertension Reports
https://www.readbyqxmd.com/read/24710747/adherence-to-transition-guidelines-in-european-paediatric-nephrology-units
#12
Thomas A Forbes, Alan R Watson, Aleksandra Zurowska, Rukshana Shroff, Sevcan Bakkaloglu, Karel Vondrak, Michel Fischbach, Johan Van de Walle, Gema Ariceta, Alberto Edefonti, Christoph Aufricht, Augustina Jankauskiene, Tuula Holta, Mesiha Ekim, Claus Peter Schmitt, Constantinos Stefanidis
BACKGROUND: There is increasing focus on the problems involved in the transition and transfer of young adult patients from paediatric to adult renal units. This situation was addressed by the 2011 International Pediatric Nephrology Association/International Society of Nephrology (IPNA/ISN) Consensus Statement on transition. METHODS: We performed a survey of transition practices of 15 paediatric nephrology units across Europe 2 years after publication of the consensus statement...
September 2014: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/24475412/chronic-kidney-disease-in-children-a-report-from-a-tertiary-care-center-over-11-years
#13
Alaleh Gheissari, Saeedeh Hemmatzadeh, Alireza Merrikhi, Sharareh Fadaei Tehrani, Yahya Madihi
BACKGROUND: Chronic kidney disease (CKD) is an overwhelming illness in children. Considering the importance of CKD in pediatric age group, in addition to the racial and ethnic differences in prevalence and etiology of CKD, epidemiologic studies are recommended. The majority of the results regarding the incidence of CKD have been achieved from studies on hospitalized children. OBJECTIVES: This study evaluates the incidence and etiology of chronic renal failure (CRF) in children in a tertiary care center in Isfahan, the second large province of Iran...
October 2012: Journal of Nephropathology
https://www.readbyqxmd.com/read/23715118/withdrawn-summary-of-kdigo-guideline-behind-the-scenes-need-for-guidance-and-a-framework-for-moving-forward
#14
Adeera Levin, Paul E Stevens
The 2102 KDIGO Guidelines for CKD evaluation, classification, and management have updated the original 2002 KDOQI Guidelines, using newer data and addressing issues raised over the last decade concerning definitions and assessment. This commentary highlights the key aspects of the CKD guidelines, and describes the rationale for specific wording and the scope of the document. A precis of key concepts in each of the five sections of the guideline is presented. The guideline document is intended for general practioners and nephrologists, and covers both adult and pediatric CKD evaluation, classification, and management...
May 29, 2013: Kidney International
https://www.readbyqxmd.com/read/23135862/a-nationwide-study-of-mass-urine-screening-tests-on-korean-school-children-and-implications-for-chronic-kidney-disease-management
#15
Byoung-Soo Cho, Won-Ho Hahn, Hae Il Cheong, Inseok Lim, Cheol Woo Ko, Su-Young Kim, Dae-Yeol Lee, Tae-Sun Ha, Jin-Soon Suh
BACKGROUND: Since 1998, urine screening tests have been performed on school children in Korea. We report the findings of the screening program that analyzed patients with proteinuria and/or hematuria. METHODS: Between 1999 and 2008, 5,114 children were referred to pediatric nephrologists at seven nationwide hospitals. Renal biopsies were performed on 1,478 children [28.79 % of total subjects; 26.77 % for isolated hematuria (IH), 9.09 % for isolated proteinuria (IP), and 51...
April 2013: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/23086591/nutritional-vitamin-d-use-in-chronic-kidney-disease-a-survey-of-pediatric-nephrologists
#16
Lindsay M Griffin, Michelle R Denburg, Justine Shults, Susan L Furth, Isidro B Salusky, Wenke Hwang, Mary B Leonard
BACKGROUND: Vitamin D deficiency may contribute to risk of cardiovascular disease, diabetes, and infections, in addition to known effects on mineral metabolism. Controversy remains regarding the use of nutritional vitamin D supplementation in chronic kidney disease (CKD), and the supplementation practices of pediatric nephrologists are unknown. METHODS: An electronic survey containing eight vignettes was sent to physician members of the International Pediatric Nephrology Association in 2011 to identify physician and patient characteristics that influence nephrologists to supplement CKD patients with nutritional vitamin D...
February 2013: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/23056801/growth-impairment-and-nutritional-status-in-children-with-chronic-kidney-disease
#17
Betul Sozeri, Sevgi Mir, Orhan Deniz Kara, Nida Dincel
OBJECTIVE: Malnutrition is closely linked to chronic kidney disease (CKD) in adult patients with poor outcome. But data on pediatric patients is inadequate. The aim of this study was to describe the prevalence of growth failure and malnutrition in pediatric CKD patients and explore the relationship of these parameters to each other and to other clinical parameters. METHODS: This study included 42 patients and 29 healthy children matched for age and gender. Patients were classified firstly in age group and secondly in therapy modalities...
September 2011: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/22968331/assessment-of-adult-formulas-for-glomerular-filtration-rate-estimation-in-children
#18
Hassib Chehade, Eric Girardin, Katia Iglesias, Pascal Ramseyer, Peter Frey, Daniel Bardy, Dolores Mosig, Francois Cachat
BACKGROUND: Estimated glomerular filtration rate (eGFR) is an important diagnostic instrument in clinical practice. The National Kidney Foundation-Kidney Disease Quality Initiative (NKF-KDOQI) guidelines do not recommend using formulas developed for adults to estimate GFR in children; however, studies confirming these recommendations are scarce. The aim of our study was to evaluate the accuracy of the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, the Modification of Diet in Renal Disease (MDRD) formula, and the Cockcroft-Gault formula in children with various stages of chronic kidney disease (CKD)...
January 2013: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/22893310/searching-the-optimal-pth-target-range-in-children-undergoing-peritoneal-dialysis-new-insights-from-international-cohort-studies
#19
REVIEW
Dieter Haffner, Franz Schaefer
The treatment of the mineral and bone disorder associated with chronic kidney disease (CKD-MBD) remains a major challenge in pediatric patients. The principal aims of therapeutic measures are not only to prevent the debilitating skeletal complications and to achieve normal growth but also to preserve long-term cardiovascular health. Serum parathyroid hormone (PTH) levels are used as a surrogate parameter of bone turnover. Whereas it is generally accepted that serum calcium and phosphate levels should be kept within the range for age, current pediatric consensus guidelines differ markedly with respect to the optimal PTH target range and operate on a limited evidence base...
April 2013: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/22760413/why-multidisciplinary-clinics-should-be-the-standard-for-treating-chronic-kidney-disease
#20
EDITORIAL
Guido Filler, Steven E Lipshultz
In adults, strong evidence indicates that slowing progression of chronic kidney disease (CKD) requires an integrated, multidisciplinary approach. In children, however, this approach has not been studied. This editorial commentary to the study by Ajarmeh et al in this volume of Pediatric Nephrology highlights how a dedicated, multidisciplinary team of physicians, nurses, pharmacists, dieticians, social workders and clinic data managers slowed the progression of CKD in children to a remarkable degree. We discuss the strengths and limitations of the study and its cost implications, as well as the issue of determining the optional complement of physicians and allied health care professionals in such clinics...
October 2012: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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