keyword
https://read.qxmd.com/read/38516112/an-evaluation-of-cephalometric-predictors-of-anterior-open-bite-an-assessment-of-dental-and-skeletal-parameters-in-an-orthodontic-population
#1
JOURNAL ARTICLE
Onyinye D Umeh, Sylvester Chegwe, Ifeoma L Utomi
BACKGROUND: Anterior open bite (AOB) malocclusion is one of the highly challenging malocclusions. Cephalometric radiographs have been used for the diagnosis of occlusal anomalies in the vertical and anteroposterior directions. This study aims to compare skeletal and dental features in open and non-open bite subjects to identify factors that help predict and categorize open bites in a Nigerian population. MATERIALS AND METHODS: Pretreatment cephalometric radiographs of 82 patients were recruited into this study...
2024: Journal of Orthodontic Science
https://read.qxmd.com/read/38515720/circulating-tigit-%C3%A2-pd1-tph-tigit-%C3%A2-pd1-tfh-cells-are-elevated-and-their-predicting-role-in-systemic-lupus-erythematosus
#2
JOURNAL ARTICLE
Qing Luo, Qiuyun Xiao, Lu Zhang, Biqi Fu, Xue Li, Zikun Huang, Junming Li
It is well established that increased peripheral helper T cells (TPH) and follicular helper T cells (TFH) was found in systemic lupus erythematosus (SLE) patients. However, the expression patterns and immunomodulatory roles of TIGIT and PD1 on TPH/TFH in SLE are poorly understood. The expression patterns of TIGIT and PD1 on TPH and TFH cells were examined using flow cytometry and their expression patterns in SLE patients were then further evaluated for their correlation with auto-antibodies, disease activity and severity, B cell differentiation...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38514095/th2-skewed-peripheral-t-helper-cells-drives-b-cells-in-allergic-bronchopulmonary-aspergillosis
#3
JOURNAL ARTICLE
Rong-Guang Luo, Yi-Fan Wu, Hai-Wen Lu, Dong Weng, Jia-Yan Xu, Le-Le Wang, Li-Sha Zhang, Cai-Qi Zhao, Jian-Xiong Li, Yong Yu, Xin-Ming Jia, Jin-Fu Xu
INTRODUCTION: Patients with allergic bronchopulmonary aspergillosis (ABPA) suffer from repeated exacerbations. However, the involvement of T cell subsets remains unclear. METHODS: We enrolled ABPA patients, asthma patients and healthy controls. Th1, Th2, Th17, Treg and IL-21+ CD4+ T cells in total or sorted subsets of peripheral blood mononuclear cells (PBMCs) and ABPA Bronchoalveolar Lavage fluid (BALF) were analyzed by flow cytometry. RNA sequencing of subsets of CD4+ T cells were done in exacerbated ABPA patients and healthy controls...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38508431/bushen-formula-promotes-the-decrease-of-hbsag-levels-in-patients-with-chb-by-regulating-tfh-cells-and-b-cell-subsets
#4
JOURNAL ARTICLE
Longshan Ji, Jinghan Wei, Rongjie Zhang, Xin Zhang, Yating Gao, Miao Fang, Zhuo Yu, Lin Cao, Yueqiu Gao, Man Li
ETHNOPHARMACOLOGICAL RELEVANCE: Bushen Formula (BSF) is the effective traditional Chinese medicine (TCM) for chronic hepatitis B (CHB) according to our previous researches. However, the special effectiveness of BSF treating CHB patients in different stages and the immunoregulatory mechanisms remain to be explored. AIM OF THE STUDY: To compare the therapeutic effects of BSF in both treatment-naive patients and Peg-IFN-α-treated patients, and explore the potential mechanism of immunomodulation...
March 18, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38507351/correction-enhancing-specific-antibody-production-to-the-ragb-vaccine-with-gitrl-that-expand-tfh-ifn-%C3%AE-t-cells-and-attenuates-porphyromonas-gingivalis-infection-in-mice
#5
Dong Zheng, Qiang Sun, Zhaoliang Su, Fanzhi Kong, Xiaoju Shi, Jia Tong, Pei Shen, Tianqing Peng, Shengjun Wang, Huaxi Xu
[This corrects the article DOI: 10.1371/journal.pone.0059604.].
2024: PloS One
https://read.qxmd.com/read/38506241/clinicopathological-features-of-adult-t-cell-leukemia-lymphoma-with-t-follicular-helper-phenotype
#6
JOURNAL ARTICLE
Reiji Muto, Hiroaki Miyoshi, Kazutaka Nakashima, Mai Takeuchi, Makoto Hamasaki, Koichi Ohshima
AIMS: T-follicular helper (TFH) cells are effector T-cells that are crucial for B-cell selection and differentiation. T-cell lymphomas derived from TFH cells have distinct characteristics. Additionally, in the World Health Organization (WHO) classification 5th edition, three lymphomas were introduced as independent disease entities with TFH cell origin. We aimed to investigate the clinicopathological features of adult T-cell leukemia/lymphoma (ATLL) with a TFH phenotype (TFHP). METHODS AND RESULTS: We performed TFH immunohistochemistry analysis of five biomarkers for the biopsy specimen, with TFHP being indicated by a positive result for more than two markers...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38501859/id1-expression-in-cd4-t-cells-promotes-differentiation-and-function-of-follicular-helper-t-cells-and-upregulation-of-related-functional-molecules
#7
JOURNAL ARTICLE
Chen Liu, Xingyue Zeng, Ziqi Xiong, Ayibaota Bahabayi, Ainizati Hasimu, Tianci Liu, Mohan Zheng, Liwei Ren, Xiayidan Alimu, Songsong Lu
Although the roles of E proteins and inhibitors of DNA-binding (Id) in T follicular helper (TFH) and T follicular regulatory (TFR) cells have been previously reported, direct models demonstrating the impact of multiple E protein members have been lacking. To suppress all E proteins including E2A, HEB and E2-2, we overexpressed Id1 in CD4 cells using a CD4-Id1 mouse model, to observe any changes in TFH and TFR cell differentiation. Our objective was to gain better understanding of the roles that E proteins and Id molecules play in the differentiation of TFH and TFR cells...
March 19, 2024: Immunology
https://read.qxmd.com/read/38501122/a-multiscale-spatial-modeling-framework-for-the-germinal-center-response
#8
Derek P Mu, Christopher D Scharer, Norbert E Kaminski, Qiang Zhang
The germinal center response or reaction (GCR) is a hallmark event of adaptive humoral immunity. Unfolding in the B cell follicles of the secondary lymph organs, a GC culminates in the production of high-affinity antibody-secreting plasma cells along with memory B cells. By interacting with follicular dendritic cells (FDC) and T follicular helper (Tfh) cells, GC B cells exhibit complex spatiotemporal dynamics. Driving the B cell dynamics are the intracellular signal transduction and gene regulatory network that responds to cell surface signaling molecules, cytokines, and chemokines...
January 30, 2024: bioRxiv
https://read.qxmd.com/read/38492746/migratory-cd103-cd11b-cdc2-cells-in-peyer-s-patches-are-critical-for-gut-iga-responses-following-oral-immunization
#9
JOURNAL ARTICLE
Inta Gribonika, Anneli Strömberg, Rakesh K Chandode, Karin Schön, Katharina Lahl, Mats Bemark, Nils Lycke
Induction and regulation of specific intestinal IgA responses critically depend on dendritic cell subsets and the T cells they activate in the Peyer's patches (PP). We found that oral immunization with cholera toxin (CT) as an adjuvant resulted in migration-dependent changes in the composition and localization of PP DC subsets with increased numbers of CD103- cDC2s and LysoDCs in the subepithelial dome and of CD103+ cDC2s that expressed CD101 in the T cell zones (TZ), while oral OVA tolerization was instead associated with larger quantities of TZ cDC1s and pTregs...
March 14, 2024: Mucosal Immunology
https://read.qxmd.com/read/38485150/b-cells-in-pulmonary-arterial-hypertension-friend-foe-or-bystander
#10
REVIEW
Sébastien Sanges, Wen Tian, Sylvain Dubucquoi, Jason L Chang, Aurore Collet, David Launay, Mark R Nicolls
There is an unmet need for new therapeutic strategies that target alternative pathways to improve the prognosis of patients with pulmonary arterial hypertension (PAH). As immunity has been involved in the development and progression of vascular lesions in PAH, we review the potential contribution of B cells in its pathogenesis and evaluate the relevance of B cell-targeted therapies. Circulating B cell homeostasis is altered in PAH patients, with total B-cell lymphopenia, abnormal subset distribution (expansion of naïve and antibody-secreting cells, reduction of memory B cells) and chronic activation...
March 14, 2024: European Respiratory Journal
https://read.qxmd.com/read/38484812/self-assembled-ferritin-based-nanoparticles-elicit-a-robust-broad-spectrum-protective-immune-response-against-sars-cov-2-variants
#11
JOURNAL ARTICLE
Weiqi Wang, Xianyong Meng, Huan Cui, Cheng Zhang, Shen Wang, Na Feng, Yongkun Zhao, Tiecheng Wang, Feihu Yan, Xianzhu Xia
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants has resulted in global economic losses and posed a threat to human health. The pandemic highlights the urgent need for an efficient, easily producible, and broad-spectrum vaccine. Here, we present a potentially universal strategy for the rapid and general design of vaccines, focusing on the design and testing of omicron BA.5 RBD-conjugated self-assembling ferritin nanoparticles (NPs)...
March 12, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38481058/the-aged-microenvironment-impairs-bcl6-and-cd40l-induction-in-cd4-t-follicular-helper-cell-differentiation
#12
JOURNAL ARTICLE
Jacob S Fisher, Irene Adán-Barrientos, Naveen R Kumar, Jessica N Lancaster
Weakened germinal center responses by the aged immune system result in diminished immunity against pathogens and reduced efficacy of vaccines. Prolonged contacts between activated B cells and CD4+ T cells are crucial to germinal center formation and T follicular helper cell (Tfh) differentiation, but it is unclear how aging impacts the quality of this interaction. Peptide immunization confirmed that aged mice have decreased expansion of antigen-specific germinal center B cells and reduced antibody titers. Furthermore, aging was associated with accumulated Tfh cells, even in naïve mice...
March 13, 2024: Aging Cell
https://read.qxmd.com/read/38467875/imbalance-of-t%C3%A2-follicular-helper-cell-subsets-trigger-the-differentiation-of-pathogenic-b-cells-in-idiopathic-membranous-nephropathy
#13
JOURNAL ARTICLE
Bishun Deng, Huijie Huang, Li Deng, Ziling Zhao, Miao Liu, Haibiao Lin, Xiaowan Wang, Ruimin Tian, Xiaoxin Tu, Anping Peng, Enyu Liang, Kun Bao, Yuting Zhou, Peng Xu, Min He
OBJECTIVE: This study aims to elucidate the role of T follicular helper (Tfh) cells and their subsets in idiopathic membranous nephropathy (IMN). METHODS: The frequencies of Tfh cell subsets and B cell subsets in peripheral blood (PB) were detected in both IMN patients and healthy controls (HCs). The involvement of Tfh cells in the disease pathogenesis was examined by coculturing human Tfh cells with B cells. The dynamic changes of Tfh cells in PB or spleen were monitored in passive Heymann nephritis (PHN) rats...
March 11, 2024: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://read.qxmd.com/read/38464255/integrating-circulating-t-follicular-memory-cells-and-autoantibody-repertoires-for-characterization-of-autoimmune-disorders
#14
Emily M Harris, Sarah Chamseddine, Anne Chu, Leetah Senkpeil, Matthew Nikiciuk, Amer Al-Musa, Brian Woods, Elif Ozdogan, Sarife Saker, David P Hoytema van Konijnenburg, Christina S K Yee, Ryan Nelson, Pui Lee, Olha Halyabar, Rebecca C Hale, Megan Day-Lewis, Lauren A Henderson, Alan A Nguyen, Megan Elkins, Toshiro K Ohsumi, Maria Gutierrez-Arcelus, Janique M Peyper, Craig D Platt, Rachael F Grace, Brenna LaBere, Janet Chou
INTRODUCTION: Autoimmune diseases are heterogeneous and often lack specific or sensitive diagnostic tests. Increased percentages of CD4+ CXCR5+ PD1+ circulating T follicular helper (cTfh) cells and skewed distributions of cTfh subtypes have been associated with autoimmunity. However, cTfh cell percentages can normalize with immunomodulatory treatment despite persistent disease activity, indicating the need for identifying additional cellular and/or serologic features correlating with autoimmunity...
March 7, 2024: medRxiv
https://read.qxmd.com/read/38460299/evaluation-of-different-types-of-adjuvants-in-a-malaria-transmission-blocking-vaccine
#15
JOURNAL ARTICLE
Xinxin Yu, Hui Min, Shijie Yao, Guixiang Yao, Di Zhang, Biying Zhang, Muyan Chen, Fei Liu, Liwang Cui, Li Zheng, Yaming Cao
Adjuvants are critical components for vaccines, which enhance the strength and longevity of the antibody response and influence the types of immune response. Limited research has been conducted on the immunogenicity and protective efficacy of various adjuvants in malaria transmission-blocking vaccines (TBVs). In this study, we formulated a promising TBV candidate antigen, the P. berghei ookinete surface antigen PSOP25, with different types of adjuvants, including the TLR4 agonist monophosphoryl lipid A (MPLA), the TLR9 agonist cytosine phosphoguanosine oligodeoxynucleotides (CpG ODN 1826) (CpG), a saponin adjuvant QS-21, aluminum hydroxide (Alum), and two combination adjuvants MPLA + QS-21 and QS-21 + CpG...
March 8, 2024: International Immunopharmacology
https://read.qxmd.com/read/38458196/an-immune-cell-map-of-human-lung-adenocarcinoma-development-reveals-an-anti-tumoral-role-of-the-tfh-dependent-tertiary-lymphoid-structure
#16
JOURNAL ARTICLE
Wei Liu, Wenhua You, Zhenwei Lan, Yijiu Ren, Shuangshu Gao, Shuchao Li, Wei-Wei Chen, Chunyu Huang, Yong Zeng, Nengming Xiao, Zeshuai Wang, Huikang Xie, Huan Ma, Yun Chen, Guangsuo Wang, Chang Chen, Hanjie Li
The immune responses during the initiation and invasion stages of human lung adenocarcinoma (LUAD) development are largely unknown. Here, we generated a single-cell RNA sequencing map to decipher the immune dynamics during human LUAD development. We found that T follicular helper (Tfh)-like cells, germinal center B cells, and dysfunctional CD8+ T cells increase during tumor initiation/invasion and form a tertiary lymphoid structure (TLS) inside the tumor. This TLS starts with an aggregation of CD4+ T cells and the generation of CXCL13-expressing Tfh-like cells, followed by an accumulation of B cells, and then forms a CD4+ T and B cell aggregate...
March 1, 2024: Cell reports medicine
https://read.qxmd.com/read/38455461/cytokines-in-follicular-helper-t-cell-biology-in-physiologic-and-pathologic-conditions
#17
REVIEW
Jinyong Choi, Shane Crotty, Youn Soo Choi
Follicular helper T cells (Tfh) play a crucial role in generating high-affinity antibodies (Abs) and establishing immunological memory. Cytokines, among other functional molecules produced by Tfh, are central to germinal center (GC) reactions. This review focuses on the role of cytokines, including IL-21 and IL-4, in regulating B cell responses within the GC, such as differentiation, affinity maturation, and plasma cell development. Additionally, this review explores the impact of other cytokines like CXCL13, IL-10, IL-9, and IL-2 on GC responses and their potential involvement in autoimmune diseases, allergies, and cancer...
February 2024: Immune Network
https://read.qxmd.com/read/38449049/a-chimeric-porcine-reproductive-and-respiratory-syndrome-virus-1-strain-containing-synthetic-orf2-6-genes-can-trigger-t-follicular-helper-cell-and-heterologous-neutralizing-antibody-responses-and-confer-enhanced-cross-protection
#18
JOURNAL ARTICLE
Shubin Li, Ming Qiu, Shuai Li, Chen Li, Hong Lin, Yuejia Qiu, Wenhao Qi, Binghui Feng, Meng Cui, Shuai Yang, Wanglong Zheng, Shaobin Shang, Kegong Tian, Jianzhong Zhu, Yu Lu, Nanhua Chen
The prevalence of porcine reproductive and respiratory syndrome virus 1 (PRRSV1) isolates has continued to increase in Chinese swine herds in recent years. However, no effective control strategy is available for PRRSV1 infection in China. In this study, we generated the first infectious cDNA clone (rHLJB1) of a Chinese PRRSV1 isolate and subsequently used it as a backbone to construct an ORF2-6 chimeric virus (ORF2-6-CON). This virus contained a synthesized consensus sequence of the PRRSV1 ORF2-6 gene encoding all the envelope proteins...
March 6, 2024: Veterinary Research
https://read.qxmd.com/read/38447647/a-virus-like-particle-candidate-vaccine-based-on-crispr-cas9-gene-editing-technology-elicits-broad-spectrum-protection-against-sars-cov-2
#19
JOURNAL ARTICLE
Weiqi Wang, Shen Wang, Xianyong Meng, Yongkun Zhao, Nan Li, Tiecheng Wang, Na Feng, Feihu Yan, Xianzhu Xia
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with frequent mutations has seriously damaged the effectiveness of the 2019 coronavirus disease (COVID-19) vaccine. There is an urgent need to develop a broad-spectrum vaccine while elucidating the underlying immune mechanisms. Here, we developed a SARS-CoV-2 virus-like particles (VLPs) vaccine based on the Canarypox-virus vector (ALVAC-VLPs) using CRISPR/Cas9. Immunization with ALVAC-VLPs showed the effectively induce SARS-CoV-2 specific T and B cell responses to resist the lethal challenge of mouse adaptive strains...
March 4, 2024: Antiviral Research
https://read.qxmd.com/read/38436421/prmt5-promotes-t-follicular-helper-cell-differentiation-and-germinal-center-responses-during-influenza-virus-infection
#20
JOURNAL ARTICLE
Kaitlin A Read, Stephanie A Amici, Sadaf Farsi, Madeline Cutcliffe, Bella Lee, Chan-Wang Jerry Lio, Hsin-Jung Joyce Wu, Mireia Guerau-de-Arellano, Kenneth J Oestreich
Protein arginine methyltransferases (PRMTs) modify diverse protein targets and regulate numerous cellular processes; yet, their contributions to individual effector T cell responses during infections are incompletely understood. In this study, we identify PRMT5 as a critical regulator of CD4+ T follicular helper cell (Tfh) responses during influenza virus infection in mice. Conditional PRMT5 deletion in murine T cells results in an almost complete ablation of both Tfh and T follicular regulatory populations and, consequently, reduced B cell activation and influenza-specific Ab production...
March 4, 2024: Journal of Immunology
keyword
keyword
41311
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.