Emily M Harris, Sarah Chamseddine, Anne Chu, Leetah Senkpeil, Matthew Nikiciuk, Amer Al-Musa, Brian Woods, Elif Ozdogan, Sarife Saker, David P Hoytema van Konijnenburg, Christina S K Yee, Ryan Nelson, Pui Lee, Olha Halyabar, Rebecca C Hale, Megan Day-Lewis, Lauren A Henderson, Alan A Nguyen, Megan Elkins, Toshiro K Ohsumi, Maria Gutierrez-Arcelus, Janique M Peyper, Craig D Platt, Rachael F Grace, Brenna LaBere, Janet Chou
INTRODUCTION: Autoimmune diseases are heterogeneous and often lack specific or sensitive diagnostic tests. Increased percentages of CD4+ CXCR5+ PD1+ circulating T follicular helper (cTfh) cells and skewed distributions of cTfh subtypes have been associated with autoimmunity. However, cTfh cell percentages can normalize with immunomodulatory treatment despite persistent disease activity, indicating the need for identifying additional cellular and/or serologic features correlating with autoimmunity...
March 7, 2024: medRxiv