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Follicle T cell

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https://www.readbyqxmd.com/read/29769782/graft-versus-host-disease-presenting-as-fibrosing-alopecia-in-a-pattern-distribution-a-model-for-pathophysiological-understanding-of-cicatricial-pattern-hair-loss
#1
Hudson Dutra Rezende, Maria Fernanda Reis Gavazzoni Dias, Ralph Michel Trüeb
A case of cutaneous graft versus host disease (GvHD) presenting as fibrosing alopecia in a pattern distribution (FAPD) is discussed, possibly providing a mechanistic model for a better understanding of the pathogenic events underlying cicatricial pattern hair loss. The implication of a follicular inflammation and fibrosis associated with patterned hair loss has emerged from several independent studies. Eventually, Zinkernagel and Trüeb reported a peculiar type of cicatricial pattern hair loss with histopathological features consistent with lichen planopilaris (LPP) associated with androgenetic alopecia (AGA)...
March 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29769249/spatial-distribution-and-function-of-t-follicular-regulatory-cells-in-human-lymph-nodes
#2
Ismail Sayin, Andrea J Radtke, Laura A Vella, Wenjie Jin, E John Wherry, Marcus Buggert, Michael R Betts, Ramin S Herati, Ronald N Germain, David H Canaday
T follicular regulatory (Tfr) cells are a population of CD4+ T cells that express regulatory T cell markers and have been shown to suppress humoral immunity. However, the precise mechanisms and location of Tfr-mediated suppression in the lymph node (LN) microenvironment are unknown. Using highly multiplexed quantitative imaging and functional assays, we examined the spatial distribution, suppressive function, and preferred interacting partners of Tfr cells in human mesenteric LNs. We find that the majority of Tfr cells express low levels of PD-1 and reside at the border between the T cell zone and B cell follicle, with very few found in the germinal centers (GCs)...
May 16, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29765972/reflectance-confocal-microscopy-as-new-diagnostic-tool-in-folliculotropic-mycosis-fungoides
#3
Gabriella Fabbrocini, Caterina Mazzella, Mariateresa Cantelli, Antonello Baldo, Daniela Russo, Gaetano De Rosa, Giuseppe Monfrecola
We present a case of folliculotropic mycosis fungoides (FMF), a variant of cutaneous T-cell lymphoma which particularly affects hair follicles. FMF can imitate a wide variety of otherwise benign dermatoses, so it poses major diagnostic obstacles both for the dermatologist as well as the dermatopathologist. In our case, in vivo reflectance confocal microscopy (RCM) was very important for guiding the skin biopsy site selection. For this reason, RCM can reduce the number of unsuccessful histopathological examinations and increase the diagnostic accuracy for different skin dermatoses...
April 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29762821/the-influencing-mechanism-of-mtor-signal-pathway-mediated-by-mitofusin-2-in-development-of-follicle
#4
Q-Y Luo, P Huo, L-L Wang, X-H Wu
OBJECTIVE: To investigate the influencing mechanism of mammalian target of rapamycin (mTOR) signal pathway mediated by mitofusin-2 (Mfn2) in the development of follicle. MATERIALS AND METHODS: We selected 20 healthy Sprague Dawley (SD) female rats aging between 6 and 8 weeks were divided into the control group and the polycystic ovarian syndrome (PCOS) model group. Rats in PCOS group received the lavage using 0.4 mL 1% carboxymethyl cellulose solution containing letrozole (1 mg/kg/d) consecutively for 20 to 25d...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29761053/nature-derived-lignan-compound-vb-1-exerts-hair-growth-promoting-effects-by-augmenting-wnt-%C3%AE-catenin-signaling-in-human-dermal-papilla-cells
#5
Jieshu Luo, Mengting Chen, Yingzi Liu, Hongfu Xie, Jian Yuan, Yingjun Zhou, Jinsong Ding, Zhili Deng, Ji Li
Background: Vitexin is a kind of lignan compound which has been shown to possess a variety of pharmacological effects, such as anti-inflammatory, anti-oxidative and anti-cancer activities. However the effect of vitexin on hair regeneration has not been elaborated. Methods: The proliferation of human dermal papilla cells (hDPCs) was examined by cell counting and continuous cell culture after vitexin compound 1 (VB-1) was treated. The expression of lef1 , wnt5a , bmp2 , bmp4 , alpl and vcan was examined by RT-PCR...
2018: PeerJ
https://www.readbyqxmd.com/read/29756706/ovarian-masses-in-infant-juvenile-age
#6
Kaan Sonmez, Zafer Turkyilmaz, Ramazan Karabulut, A Can Basaklar
INTRODUCTION: The appropraite surgical treatment to pediatric patients with ovarian lesions are heterogeneous and ovarian preservation is desirable in children. The aim of this study is to the discuss findings related to a set of patients who were operated on for ovarian lesions. PATIENTS AND METHODS: A retrospective study carried out in 13 years on 56 patients under the age of 17. These patients were divided into 3 groups according to ovarian pathologic diagnosis: 25 with functional (cyts and torsion), 18 with epithelial ovarian lesions and 13 with germ cell tumours...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29755273/orbital-progressive-transformation-of-germinal-centers-as-part-of-the-spectrum-of-igg4-related-ophthalmic-disease-clinicopathologic-features-of-three-cases
#7
M Adelita Vizcaino, Shannon S Joseph, Charles G Eberhart
Progressive transformation of germinal centers (PTGC) is a form of follicular hyperplasia recently associated with immunoglobulin G4-related disease (IgG4-RD), but the ophthalmic manifestations of this combination are poorly described. In this retrospective case series, we present three cases of IgG4-related orbital disease (IgG4-ROD) showing varying degrees of PTGC involving the orbit and lacrimal gland. Three adult women presented with ill-defined lacrimal gland enlargement. Histologic sections showed variable fibrosis and large, irregular lymphoid follicles with prominent mantle zones penetrating the germinal centers, highlighted by Bcl-2 and/or IgD immunostains...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29754696/follicle-stimulating-hormone-receptor-protein-is-expressed-in-ovine-uterus-during-the-estrous-cycle-and-utero-placenta-during-early-pregnancy-an-immunohistochemical-study
#8
Anna T Grazul-Bilska, Arshi Reyaz, Veselina Valkov, Sheri T Dorsam, Dale A Redmer
Follicle stimulating hormone (FSH) is a well characterized gonadotropin that controls primarily development and functions of ovarian follicles in mammalian species. FSH binds to a specific G protein-coupled receptor (FSHR) belonging to the glycoprotein hormone receptor family that plays an essential role in reproduction. Although the primary location of FSHR is in the gonads (mainly in ovarian follicles), FSHR protein and/or mRNA have also been detected in extragonadal female reproductive tissues including embryo, placenta, endometrium, cervix, ovarian cancer tissues, and/or endometriotic lesions in several species...
May 11, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29751768/the-preclinical-evaluation-of-immunocontraceptive-vaccines-based-on-canine-zona-pellucida-3-czp3-in-a-mouse-model
#9
Ying Wang, Yijie Li, Beibei Zhang, Fuchun Zhang
BACKGROUND: Stray dogs are the reservoirs and carriers of rabies and are definitive hosts of echinococcosis. To control the overpopulation of stray dogs, zona pellucida 3 (ZP3), a primary receptor for sperm, is a potential antigen for developing contraceptive vaccines. To enhance the immune responses and contraceptive effects of canine ZP3 (cZP3), dog gonadotropin-releasing hormone (GnRH) and a T cell epitope of chicken ovalbumin (OVA) were selected to construct two fusion proteins with cZP3, ovalbumin-GnRH-ZP3 (OGZ) and ovalbumin-ZP3 (OZ), and their contraceptive effects were evaluated in mice...
May 11, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29743364/t-cell-derived-lymphotoxin-is-essential-for-anti-hsv-1-humoral-immune-response
#10
Kaiting Yang, Yong Liang, Zhichen Sun, Diyuan Xue, Hairong Xu, Mingzhao Zhu, Yang-Xin Fu, Hua Peng
B cell-derived lymphotoxin (LT) is required for the development of follicular dendritic cell clusters for the formation of primary and secondary lymphoid follicles, but the role of T cell-derived LT in antibody response has not been well demonstrated. We observed that lymphotoxin-β-receptor (LTβR) signaling is essential for optimal humoral immune response and protection against an acute HSV-1 infection. Blocking the LTβR pathway caused poor maintenance of germinal center B (GC-B) cells and follicular helper T (Tfh) cells...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29743314/cd8-follicular-t-cells-promote-b-cell-antibody-class-switch-in-autoimmune-disease
#11
Kristen M Valentine, Dan Davini, Travis J Lawrence, Genevieve N Mullins, Miguel Manansala, Mufadhal Al-Kuhlani, James M Pinney, Jason K Davis, Anna E Beaudin, Suzanne S Sindi, David M Gravano, Katrina K Hoyer
CD8 T cells can play both a protective and pathogenic role in inflammation and autoimmune development. Recent studies have highlighted the ability of CD8 T cells to function as T follicular helper (Tfh) cells in the germinal center in the context of infection. However, whether this phenomenon occurs in autoimmunity and contributes to autoimmune pathogenesis is largely unexplored. In this study, we show that CD8 T cells acquire a CD4 Tfh profile in the absence of functional regulatory T cells in both the IL-2-deficient and scurfy mouse models...
May 9, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29734775/characterization-of-an-n-terminal-non-core-domain-of-rag1-gene-disrupted-syrian-hamster-model-generated-by-crispr-cas9
#12
Jinxin Miao, Baoling Ying, Rong Li, Ann E Tollefson, Jacqueline F Spencer, William S M Wold, Seok-Hwan Song, Il-Keun Kong, Karoly Toth, Yaohe Wang, Zhongde Wang
The accumulating evidence demonstrates that Syrian hamsters have advantages as models for various diseases. To develop a Syrian hamster ( Mesocricetus auratus ) model of human immunodeficiency caused by RAG1 gene mutations, we employed the CRISPR/Cas9 system and introduced an 86-nucleotide frameshift deletion in the hamster RAG1 gene encoding part of the N-terminal non-core domain of RAG1. Histological and immunohistochemical analyses demonstrated that these hamsters (referred herein as RAG1-86nt hamsters) had atrophic spleen and thymus, and developed significantly less white pulp and were almost completely devoid of splenic lymphoid follicles...
May 6, 2018: Viruses
https://www.readbyqxmd.com/read/29732234/microrna-mediated-regulation-of-the-development-and-functions-of-follicular-helper-t-cells
#13
REVIEW
Jeonghyun Lee, Hyosung Park, Jiyoung Eom, Seung Goo Kang
The germinal center reaction is a key event of humoral immunity, providing long-lived immunological memory. Follicular helper T (TFH ) cells are a specialized subset of CD4+ T cells located in the follicles, which help B cells and thus control the germinal center reaction. TFH cell development is achieved by multi-step processes of interactions with dendritic cells and B cells along with the coordination of various transcription factors. Since the T helper cell fate decision program is determined by subtle changes in regulatory molecules, fine tuning of these dynamic interactions is crucial for the generation functional TFH cells...
April 2018: Immune Network
https://www.readbyqxmd.com/read/29729115/tissue-expression-of-aquaporine-3-in-different-sites-of-vitiligo-an-immunohistochemical-study
#14
S M Esmat, O A Zeid, D M Abdel Halim, M T Fawzy, M Abdel Latif, V Lazarova, M Assaf
The role of epidermal keratinocytes in the pathogenesis of vitiligo has been ignored despite the fact that both melanocytes and keratinocytes form one functional and structural unit. Aquaporin3 (AQP3), a glycerol water channel expressed in epithelial tissue, is involved in the regulation of keratinocyte proliferation, cell migration, and has a potential role in hypopigmentation in vitiligo. Normally, acral skin differs significantly from non-acral skin. Acral skin shows significantly lower hair follicle density, melanocyte density, Langerhans cell (LC) density, epidermal MHCII expression...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29726656/-aerobic-exercise-improves-spermatogenesis-of-male-rats-results-of-itraq-based-proteomic-analysis-of-the-testis-tissue
#15
Yu-Ping Guo, En-Zhong Li, You-Jing Zhang, An-Li Wang
Objective: To investigate the effect of aerobic exercise on the spermatogenic function of male rats and screen out differentially expressed proteins related to spermatonesis-regulation by proteomic analysis. METHODS: We randomly divided 24 SD male rats into groups A (non-exercise control), B (exercise), and C (weight-bearing exercise), those in the latter two groups made to swim for 60 minutes a day and those in group C bearing a load 3% of the body weight, both 6 times a week for 9 weeks...
September 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29725327/lymph-node-cellular-and-viral-dynamics-in-natural-hosts-and-impact-for-hiv-cure-strategies
#16
REVIEW
Nicolas Huot, Steven E Bosinger, Mirko Paiardini, R Keith Reeves, Michaela Müller-Trutwin
Combined antiretroviral therapies (cARTs) efficiently control HIV replication leading to undetectable viremia and drastic increases in lifespan of people living with HIV. However, cART does not cure HIV infection as virus persists in cellular and anatomical reservoirs, from which the virus generally rebounds soon after cART cessation. One major anatomical reservoir are lymph node (LN) follicles, where HIV persists through replication in follicular helper T cells and is also trapped by follicular dendritic cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29719020/primary-cutaneous-b-cell-lymphomas-clinical-and-histopathologic-features-differential-diagnosis-and-treatment
#17
Steven T Chen, Jeffrey Barnes, Lyn Duncan
Cutaneous B-cell lymphomas (CBCLs) are a heterogeneous group of diseases that can have variable presentations, prognoses, and treatments. The proper identification of a CBCL hinges on proper histopathologic and clinical evaluation. Comprising 25% to 30% of the primary cutaneous lymphomas, incident cases of CBCL are rare. Given the variable natural history of the CBCL, proper classification is critical so that patients are treated appropriately. CBCLs can be divided into 2 main groups: indolent and aggressive...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29715493/spleen-development-is-modulated-by-neonatal-gut-microbiota
#18
M Manuela Rosado, Alaitz Aranburu, Marco Scarsella, Simona Cascioli, Ezio Giorda, Federica Del Chierico, Stefano Levi Mortera, Eva Piano Mortari, Stefania Petrini, Lorenza Putignani, Rita Carsetti
The full development of the mammalian immune system occurs after birth upon exposure to non self-antigens. The gut is the first site of bacterial colonization where it is crucial to create the appropriate microenvironment able to balance effector or tolerogenic responses to external stimuli. It is a well-established fact that at mucosal sites bacteria play a key role in developing the immune system but we ignore how colonising bacteria impact the maturation of the spleen. Here we addressed this issue. Taking advantage of the fact that milk SIgA regulates bacterial colonization of the newborn intestine, we generated immunocompetent mice born either from IgA pro-efficient or IgA deficient females...
April 28, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29696926/-protective-effects-of-electroacupuncture-pretreatment-on-ovarian-in-rats-with-premature-ovarian-insufficiency
#19
Weiming Wang, Yang Wang, Jiani Wu, Likun Yang, Zhishun Liu
OBJECTIVE: To explore the protective effect and possible mechanism of electroacupuncture (EA) pretreatment at "Zhongliao" (BL 33) and "Tianshu" (ST 25) on ovarian in rats with premature ovarian insufficiency (POI). METHODS: A total of 32 SD female rats with regular estrus were randomly divided into a blank group, a model group, an EA group and an immobilization group, 8 rats in each one. The rats in the model group, EA group and immobilization group were treated with intraperitoneal injection of 4-vinylcyclohexene diepoxide (160 mg/kg) for 15 days to establish the model...
April 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29684365/leucocyte-dynamics-during-the-evolution-of-human-coronary-atherosclerosis-conclusions-from-a-7-fold-chromogen-based-immunohistochemical-evaluation
#20
Melissa Zuiderwijk, Marlieke Geerts, Connie Janssen van Rhijn, Antoon van den Bogaerdt, Jaap F Hamming, Rogier A van Dijk, Jan H Lindeman
Atherosclerosis is a complex process with strong inflammatory component. We developed a straightforward 7-fold staining protocol for simultaneous assessment of dominant leucocyte classes, vascularization, and expression of the putative foam cell maker CD36. The method was applied on human coronaries covering the full spectrum of atherosclerotic disease. Results confirm the progressive association of macrophages and T-cells with the process, and a global presence of mast cells. B-cells exclusively present in adventitial follicles that accompany the process plaque destabilization (thin cap and ruptured lesions) and are otherwise absent...
April 20, 2018: American Journal of Pathology
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