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Follicle T cell

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https://www.readbyqxmd.com/read/28521851/regulation-of-interleukin-11-expression-in-ovulatory-follicles-of-the-rat-ovary
#1
You-Jee Jang, You-Jee Jang, Jae-Il Park, Jae-Il Park, Seong-Eun Jeong, Seong-Eun Jeong, You-Mi Seo, You-Mi Seo, Phuong T M Dam, Phuong T M Dam, Young-Woo Seo, Young-Woo Seo, Bum-Chae Choi, Bum-Chae Choi, Sang-Jin Song, Sang-Jin Song, Sang-Young Chun, Sang-Young Chun, Moon-Kyoung Cho, Moon-Kyoung Cho
The aim of the present study was to examine the regulation of interleukin (IL)-11 expression, as well as the role of IL-11, during ovulation in gonadotropin-primed immature rats. Injection of equine chorionic gonadotropin (eCG), followed by human CG (hCG) to induce superovulation stimulated expression of the Il11 gene in theca cells within 6h, as revealed by northern blot and in situ hybridisation analyses. Real-time reverse transcription-polymerase chain reaction analysis showed that the IL-11 receptor, α subunit gene was expressed in granulosa and theca cells and that injection of hCG had no effect on its expression...
May 19, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28516243/clinical-characteristics-risk-factors-and-long-term-outcome-of-114-patients-with-folliculotropic-mycosis-fungoides
#2
Iris Wieser, Casey Wang, Silvia Alberti-Violetti, Genevieve Lyons, Casey Tran, Rakshandra Talpur, Madeleine Duvic
Folliculotropic mycosis fungoides (FMF) is a distinct variant of mycosis fungoides (MF) where atypical T-cells invade the hair follicles. The objective was to assess the clinical features, risk factors for progression, long-term outcome and response to treatment modalities in a large cohort of FMF patients. We, therefore, conducted a single-center retrospective study, reviewing 114 patients with FMF seen from 1987 to 2015 at the cutaneous T-cell lymphoma clinic of the MD Anderson Cancer Center. The mean age at diagnosis of FMF was 57...
May 17, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28511863/expression-of-tnf-%C3%AE-system-members-in-bovine-ovarian-follicles-and-the-effects-of-tnf-%C3%AE-or-dexamethasone-on-preantral-follicle-survival-development-and-ultrastructure-in-vitro
#3
A W B Silva, R P Ribeiro, V G Menezes, R S Barberino, J R S Passos, A M P Dau, J J N Costa, L R F Melo, F T G Bezerra, M A M Donato, C A Peixoto, M H T Matos, P B D Gonçalves, R van den Hurk, J R V Silva
This study was conducted to detect the protein expression of TNF-α system members (TNF-α/TNFR1/TNFR2) in bovine ovarian follicles and to evaluate the effects of TNF-α or dexamethasone on the survival and growth of primordial follicles in vitro, as well as on gene expression in cultured ovarian tissue. It was hypothesized that TNF-α induces follicular atresia in ovarian tissues cultured in vitro, and that dexamethasone suppresses the production of endogenous TNF-α, which can improve follicle viability in vitro...
May 6, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28503175/heterogeneity-of-phenotype-and-function-reflects-the-multistage-development-of-t-follicular-helper-cells
#4
Marta Trüb, Tom A Barr, Vicky L Morrison, Sheila Brown, Stefano Caserta, Jordan Rixon, Alasdair Ivens, David Gray
T follicular helper cells (Tfh) provide crucial signals for germinal center (GC) formation, but Tfh populations are heterogeneous. While PD1(hi) Tfh are important in the GC response, the function of the PD1(lo) Tfh-like subset is unknown. We show that these cells, like the PD1(hi) GC-Tfh, depend upon B cells; however, their entry to follicles is independent of CXCR5 or cognate interactions with B cells. The differentiation into PD1(hi) Tfh is dependent on MHC class II interactions with B cells and requires CXCR5...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28472976/the-effect-of-dehydroepiandrosterone-supplementation-on-ovarian-response-is-associated-with-androgen-receptor-in-diminished-ovarian-reserve-women
#5
Qiaofei Hu, Liming Hong, Mingyue Nie, Qin Wang, Ying Fang, Yinmei Dai, Yanhong Zhai, Shuyu Wang, Chenghong Yin, Xiaokui Yang
BACKGROUND: Diminished ovarian reserve(DOR) is associated with female infertility and poor response to ovarian stimulation. Our objective was to assess the effect of dehydroepiandrosterone(DHEA) on DOR women and to explore whether the improvement of ovarian response after DHEA supplementation was dependent on the expression levels of androgen receptor(AR). METHODS: A prospective cohort study was performed in the Department of Human Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital during August 2014 to August 2016...
May 4, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28467980/distinct-distribution-of-immunocytes-in-a-retropharyngeal-lymphadenopathy-associated-with-kawasaki-disease-a-case-study-compared-with-tonsillitis
#6
Seigo Okada, Yuki Kobayashi-Fujiwara, Atsunori Oga, Takashi Furuta, Kenzo Ikemoto, Hironori Fujii, Yasufumi Sakata, Yasuo Suzuki, Shunji Hasegawa, Takeshi Kusuda, Hiroshi Itoh, Hiroshi Yamashita, Shouichi Ohga
OBJECTIVES: Retropharyngeal lesions are often associated with Kawasaki disease (KD). A 4-year-old male first presented a peritonsillar and retropharyngeal abscess-like lesion. Surgical tonsillectomy was performed to avoid a risk of mediastinal abscess, but he fulfilled the diagnostic criteria of KD after the operation. This prompted us to perform a histological study on the KD tonsils. METHODS: The histopathology of the KD tonsil specimens were compared with hypertrophic tonsils obtained from 4 patients with chronic tonsillitis unrelated to KD assessed by the immunostainings...
May 4, 2017: Cardiology
https://www.readbyqxmd.com/read/28458453/suppressive-effects-of-the-expectorant-drug-ambroxol-hydrochloride-on-quartz-induced-lung-inflammation-in-f344-rats
#7
Shohei Kanie, Masanao Yokohira, Keiko Yamakawa, Yuko Nakano-Narusawa, Shota Yoshida, Nozomi Hashimoto, Katsumi Imaida
Surfactant proteins (SPs) are essential to respiratory structure and function. The expectorant drug ambroxol hydrochloride is clinically prescribed to stimulate pulmonary surfactant and airway serous secretion. Therefore, ambroxol hydrochloride may affect SP production and pulmonary inflammation. Lung toxicity of fine particles of various materials has been examined previously in our in vivo bioassay using the intratracheal (i.t.) instillation approach. In the present study, we evaluated modulatory effects of ambroxol hydrochloride on quartz-induced lung inflammation in F344 rats...
April 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28453298/primary-ovarian-insufficiency-with-t-5-13-a-case-report-and-literature-review-on-disrupted-genes
#8
F Mohamadhashem, M Rafati, F Hoseininasab, S Rostami, R Tabatabaie, S Rezai, M Keramatipour, S R Ghaffari
OBJECTIVES: To report a woman with primary ovarian insufficiency (POI) with reciprocal translocation between chromosomes 5 and 13. METHODS: Chromosomal analysis (G-banding) of a 39-year-old woman with elevated gonadotropin levels and secondary amenorrhea and review of the literature with a special focus on disrupted genes at the reported breakpoints. RESULTS: A reciprocal translocation between the long arms of chromosomes 5 and 13 was identified in the patient (46,XX,t(5;13)(q13;q14))...
April 28, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28442641/regulation-of-uridine-diphosphate-glucuronosyltransferase-2b15-expression-during-ovulation-in-the-rat
#9
Phuong T M Dam, You-Jee Jang, Jae-Il Park, Bum-Chae Choi, Sang-Jin Song, Sang-Young Chun
Uridine diphosphate-glucuronosyltransferase 2B15 (UGT2B15) conjugates 5α-androstane-3α, 17β-diol (3α-diol) to 3α-diol glucuronide (3α-diol G) in steroid target tissues. The present study investigated the regulation of UGT2B15 expression during the ovulatory process in the rat. Real-time PCR analysis revealed that treatment of immature rats with equine chorionic gonadotropin followed by human chorionic gonadotropin transiently stimulated UGT2B15 gene expression in granulosa cells of preovulatory follicles within 6 h...
April 22, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28441047/distribution-of-t-cell-markers-cd4-and-cd8%C3%AE-in-lymphoid-organs-of-healthy-newborn-juvenile-and-adult-highland-plateau-yaks
#10
Qian Zhang, Kun Yang, Yufeng Huang, Junfeng He, Sijiu Yu, Yan Cui
OBJECTIVE: To investigate the distribution of T-cell markers (CD4 and CD8α) in lymphoid organs of newborn, juvenile, and adult yaks. ANIMALS: 15 healthy male yaks of various ages from highland plateaus. PROCEDURES: Yaks were allocated to groups on the basis of age (newborn [1 to 7 days old; n = 5], juvenile [5 to 7 months old; 5], and adult [3 to 4 years old; 5]). The thymus, spleen, 5 mesenteric lymph nodes, and 5 hemal nodes were harvested from each yak within 10 minutes after euthanasia...
May 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28438898/cytotoxic-t-cell-functions-accumulate-when-cd4-is-downregulated-by-cd4-t-cells-in-african-green-monkeys
#11
Carol L Vinton, Alexandra M Ortiz, Nina Calantone, Joseph C Mudd, Claire Deleage, David R Morcock, Sonya Whitted, Jacob D Estes, Vanessa M Hirsch, Jason M Brenchley
African green monkeys (AGMs) are a natural host of SIV that do not develop simian AIDS. Adult AGMs naturally have low numbers of CD4(+) T cells and a large population of MHC class II-restricted CD8αα T cells that are generated through CD4 downregulation in CD4(+) T cells. In this article, we study the functional profiles and SIV infection status in vivo of CD4(+) T cells, CD8αα T cells, and CD8αβ T cells in lymph nodes, peripheral blood, and bronchoalveolar lavage fluid of AGMs and rhesus macaques (in which CD4 downregulation is not observed)...
April 24, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28433748/the-repertoire-of-epithelial-morphogenesis-on-display-progressive-elaboration-of-drosophila-egg-structure
#12
REVIEW
Juan Carlos Duhart, Travis T Parsons, Laurel A Raftery
Epithelial structures are foundational for tissue organization in all metazoans. Sheets of epithelial cells form lateral adhesive junctions and acquire apico-basal polarity perpendicular to the surface of the sheet. Genetic analyses in the insect model, Drosophila melanogaster, have greatly advanced our understanding of how epithelial organization is established, and how it is modulated during tissue morphogenesis. Major insights into collective cell migrations have come from analyses of morphogenetic movements within the adult follicular epithelium that cooperates with female germ cells to build a mature egg...
April 19, 2017: Mechanisms of Development
https://www.readbyqxmd.com/read/28432872/human-effector-memory-t-helper-cells-engage-with-mouse-macrophages-and-cause-graft-versus-host-like-pathology-in-skin-of-humanized-mice-used-in-a-nonclinical-immunization-study
#13
Balasai Sundarasetty, Valery Volk, Sebastian J Theobald, Susanne Rittinghausen, Dirk Schaudien, Vanessa Neuhaus, Constanca Figueiredo, Andreas Schneider, Laura Gerasch, Adele Mucci, Thomas Moritz, Constantin von Kaisenberg, Loukia M Spineli, Katherina Sewald, Armin Braun, Henning Weigt, Arnold Ganser, Renata Stripecke
Humanized mice engrafted with human hematopoietic stem cells and developing functional human T-cell adaptive responses are in critical demand to test human-specific therapeutics. We previously showed that humanized mice immunized with long-lived induced-dendritic cells loaded with the pp65 viral antigen (iDCpp65) exhibited a faster development and maturation of T cells. Herein, we evaluated these effects in a long-term (36 weeks) nonclinical model using two stem cell donors to assess efficacy and safety. Relative to baseline, iDCpp65 immunization boosted the output of effector memory CD4(+) T cells in peripheral blood and lymph nodes...
June 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28429464/inflammatory-features-of-frontal-fibrosing-alopecia
#14
Sophia A Ma, Sotonye Imadojemu, Kenneth Beer, John T Seykora
INTRODUCTION: Frontal fibrosing alopecia (FFA) is a cicatricial alopecia typically occurring in post-menopausal women. The etiology and pathophysiology of FFA is poorly understood but thought to be immune mediated. This study aims to further explore the extent of fibrosis and the inflammatory microenvironment by characterizing Langerhans cells (LCs), helper T cells, cytotoxic T cells, and B cells near hair follicles in FFA. METHODS: 11 paraffin-embedded tissues from patients with a clinical and histopathologic diagnosis of FFA were selected for immunohistochemical studies using CD3, CD4, CD8, CD1a, and CD20...
April 21, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28423200/cd80cd86-deficiency-disrupts-regulatory-cd4-foxp3-t-cell-homeostasis-and-induces-autoimmune-like-alopecia
#15
Ji-Hyun Bae, Woo-Sung Hwang, Yoo-Jin Jang, Yoon-Hoo Lee, Da-Eun Jang, Jung-Sik Kim, Su-Cheong Yeom
Alopecia areata (AA) is an autoimmune disease that results in spot baldness in humans. Adequate animal models for AA are currently lacking. The objective of this study was to elucidate the mechanism of autoimmune-like alopecia (ALA) in C57BL/6.CD80CD86-deficient (B6.CD80CD86(-/-) ) mice. Incidence and severity of alopecia were analyzed in 58 B6.CD80CD86(-/-) mice by using histological examination, flow cytometry, multiplex enzyme-linked immunosorbent assay, quantitative RT-PCR, and CD25 inhibition test. Both male and female B6...
April 19, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28420756/microbes-stimulate-hair-follicles
#16
Annalisa M VanHook
Commensal microbes induce hair follicles to release a chemokine that recruits regulatory T cells into neonatal skin.
April 18, 2017: Science Signaling
https://www.readbyqxmd.com/read/28418931/socs3-treatment-prevents-the-development-of-alopecia-areata-by-inhibiting-cd8-t-cell-mediated-autoimmune-destruction
#17
Zhen Gao, Yu-Qing Jin, Wei Wu
Alopecia areata is one of the most common autoimmune diseases resulting from T cell-mediated damage of hair follicles. CD8+ T cells infiltrate hair follicles and are responsible for destruction of hair follicles. However the underlying mechanisms for hair loss remain still obscure. In the present study, we identified that suppressor of cytokine signaling-3 (SOCS3), a classical inhibitor of cytokine signaling, significantly inhibits CD8+T cell maturation, interferon-γ (IFN-γ) production and alopecia areata...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28410456/use-of-bone-morphogenetic-protein-15-polymorphisms-to-predict-ovarian-stimulation-outcomes-in-infertile-brazilian-women
#18
Carla Peluso, Cecilia Goldman, Viviane Cavalcanti, Guilherme Gastaldo, Camila Martins Trevisan, Denise Maria Christofolini, Caio Parente Barbosa, Bianca Bianco
AIMS: Polymorphisms in the gene encoding bone morphogenetic protein 15 (BMP15) can result in inhibited secretion or lowered bioactivity of the BMP15 protein. BMP15 levels are associated with follicle-stimulating hormone receptor (FSHR) action on granulosa cells, wherein FSHR increases the sensitivity of ovarian follicles to follicle-stimulating hormone (FSH). In this study we evaluated the BMP15 polymorphisms A905 > G/rs3897937, C901 > T/rs17003221, and C-9 > G/rs3810682 in infertile Brazilian women in terms of anti-Mullerian hormone (AMH), FSH, and estradiol serum levels, as well as controlled ovarian hyperstimulation response and assisted reproduction outcomes...
May 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28407479/living-in-peace-host-microbiota-mutualism-in-the-skin
#19
Daniel J Campbell, Meghan A Koch
Commensal microbes colonize the skin where they promote immune development and prevent infection without inducing damaging inflammatory responses. In this issue of Cell Host & Microbe, Scharschmidt et al. (2017) show that during hair follicle development, commensals induce regulatory T cell migration to the skin to ensure cutaneous homeostasis.
April 12, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28401443/prevalence-of-hypophysitis-in-a-cohort-of-patients-with-metastatic-melanoma-and-prostate-cancer-treated-with-ipilimumab
#20
Lucia Brilli, Riccardo Danielli, Cristina Ciuoli, Luana Calabrò, Anna Maria Di Giacomo, Alfonso Cerase, Patrizia Paffetti, Fausta Sestini, Brunetta Porcelli, Michele Maio, Furio Pacini
OBJECTIVE: Ipilimumab is a human monoclonal antibody directed against cytotoxic T-lymphocyte antigen-4, that has been shown to significantly improve survival in patients with metastatic melanoma. Blocking cytotoxic T-lymphocyte antigen-4 elicits T cell activation, proliferation and anti-tumor response, but can also trigger immune-related adverse events. Among immune-related endocrinopathies, hypophysitis represents the most frequent, with an incidence up to 17% in patients treated with ipilimumab...
April 12, 2017: Endocrine
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