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Follicle T cell

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https://www.readbyqxmd.com/read/29135509/unilesional-follicular-mycosis-fungoides-report-of-6-cases-and-review-of-the-literature
#1
Cynthia M Magro, Gladys H Telang, Shabnam Momtahen
Unilesional follicular mycosis fungoides (MF) is a rare variant of cutaneous T-cell lymphoma characterized by selective involvement of the hair follicles by neoplastic T lymphocytes presenting initially as a solitary lesion occupying less than 5% of the body surface; there are 22 previous reported cases. We describe 6 patients with this rare variant of MF, all males (age range 6-64 years; mean age: 28 years) presenting with a solitary lesion primarily on the face and scalp except 1 patient who presented with a truncal lesion...
October 24, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29131281/immunohistochemical-study-on-roe-deer-haemal-nodes
#2
Yeşim Akaydın Bozkurt, Ebru Karadağ Sarı, Murat Kabak
The aim of this study was to investigate the immunohistochemical characteristics of the haemal nodes located in the abdominal and the thoracal cavity in roe deer (Capreolus capreolus). In this study, two adult male and two adult female roe deers in addition to two roe deer foetuses at the late fetal stages were used. The avidin-biotin-peroxidase technique was applied to anti-CD3, anti-CD79αcy, anti-macrophage, anti-S100 primary antibodies. Positive results were gained for all the antibodies used. Many CD3 positive T lymphocytes were seen in the lymphoid tissue areas of the fetal haemal nodes, in the germinal center of the lymph follicles of the adult haemal nodes and in their lymphatic cords...
November 13, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29111220/pd-1-hi-cxcr5-cd4-tfh-cells-play-defense-in-cancer-and-offense-in-arthritis
#3
Chunyan Gu-Trantien, Karen Willard-Gallo
T follicular helper (TFH) cells are characteristically defined by their CXCR5 positivity and homing to B cell follicles in secondary lymphoid organs (SLO). An expanded subpopulation of functionally comparable and phenotypically similar PD-1(hi)CXCR5(-)CD4(+) T cells were recently identified in breast cancer (BC) and rheumatoid arthritis (RA) to have beneficial or detrimental roles, respectively, but are they inflammatory tissue effector TFH cells?
October 27, 2017: Trends in Immunology
https://www.readbyqxmd.com/read/29106928/epithelial-mesenchymal-stem-cell-transition-in-a-human-organ-lessons-from-lichen-planopilaris
#4
H Imanishi, D M Ansell, J Chéret, M Harries, M Bertolini, N Sepp, T Bíró, E Poblet, F Jimenez, J Hardman, S Parameswara Panicker, C M Ward, R Paus
Epithelial-to-mesenchymal transition (EMT) is critical for embryonic development and wound healing, and occurs in fibrotic disease and carcinoma. Here, we show that EMT also occurs within the bulge, the epithelial stem cell (eSC) niche of human scalp hair follicles (HFs), during the inflammatory permanent alopecia, lichen planopilaris (LPP). We show that a molecular EMT signature can be experimentally induced in healthy human eSCs in situ by antagonizing E-cadherin, combined with TGF-ß1, EGF, and interferon-γ administration, which to our knowledge is previously unreported...
October 26, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29105397/the-impact-of-genetic-variation-and-gene-expression-level-of-the-follicle-stimulating-hormone-receptor-on-ovarian-reserve
#5
Zeinab Ghezelayagh, Mehdi Totonchi, Shabnam Zarei-Moradi, Ommolbanin Asadpour, Saman Maroufizadeh, Poopak Eftekhari-Yazdi, Hamid Gourabi, Anahita Mohseni-Meybodi
OBJECTIVES: Ovarian reserve is defined as the capacity of the ovary to provide fertile oocytes. Diminished ovarian reserve (DOR) is a disorder in which ovaries are prone to go through early menopause. Where this loss of function occurs before the age of 40, it results in the premature ovarian failure (POF) disease. Throughout folliculogenesis, the follicle-stimulating hormone receptor (FSHR) starts a signaling cascade in the granulosa cells where its inactivation leads to the arrest of follicle maturation and therefore adversely affects ovarian reserve...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29099340/humoral-immunity-in-mice-transplanted-with-hematopoietic-stem-cells-derived-from-human-umbilical-cord-blood-recapitulates-that-of-human-infants
#6
Justin A Walker, Raja Vuyyuru, Tim Manser, Kishore R Alugupalli
Immunodeficient mice transplanted with human hematopoietic stem cells (HSCs) have been referred to as "Human Immune System" (HIS) mice and are a translational platform for studying human immune responses in vivo. Human HSC sources used in generating HIS mice include fetal liver (FL), umbilical cord blood (CB), and adult bone marrow (BM). Since HSCs from FL, CB, and BM are produced at various stages of human development, we tested whether mice transplanted with these three HSCs differ in their immune responses...
November 3, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29089199/microrna-27a-3p-affects-estradiol-and-androgen-imbalance-by-targeting-creb1-in-the-granulosa-cells-in-mouse-polycytic-ovary-syndrome-model
#7
Mingming Wang, Mei Liu, Jing Sun, Lina Jia, Shuoqian Ma, Jun Gao, Yunyun Xu, Hongwen Zhang, Suk Ying Tsang, Xiangdong Li
Polycystic ovary syndrome (PCOS) is a common endocrine abnormality in women characterized by a menstrual disturbance with chronic anovulation and hyperandrogenism, polycystic ovaries, and insulin resistance. MicroRNAs (miRNAs) are important fine-tune regulators involved in various physiological and pathological processes, but their actions are not fully understood. In this study, we observed the increased expression of miR-27a-3p in the ovaries of mice with PCOS and explored its functions in primary mouse granulosa cells (mGCs) and the mouse granulosa-like tumor cell line, KK-1, using several approaches...
October 28, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29070465/-impact-of-golph3-expression-in-cumulus-granulosa-cells-on-outcomes-of-intracytoplasmic-sperm-injection
#8
Dian-Liang Lin, Song Quan, Yue-Fan Kang, Ai-Li Yu, Yuan Lin
OBJECTIVE: To evaluate the impact of GOLPH3 expression in cumulus granulosa cells on the outcomes of intracytoplasmic sperm injection (ICSI). METHODS: A total of 119 women receiving ICSI due to male infertility at our center between April, 2012 and June, 2014 were enrolled in the study. Cumulus granulosa cells were collected from the women for detection of GOLPH3 expressions using immunocytochemistry, Western blotting, and real-time PCR. GOLPH3 expression rate was compared between women with and without clinical pregnancy following ICSI, and the associations of GOLPH3 expression with the laboratory indicators of ICSI outcomes were assessed...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29065140/novel-insights-into-the-pathways-regulating-the-canine-hair-cycle-and-their-deregulation-in-alopecia-x
#9
Magdalena A T Brunner, Vidhya Jagannathan, Dominik P Waluk, Petra Roosje, Monika Linek, Lucia Panakova, Tosso Leeb, Dominique J Wiener, Monika M Welle
Alopecia X is a hair cycle arrest disorder in Pomeranians. Histologically, kenogen and telogen hair follicles predominate, whereas anagen follicles are sparse. The induction of anagen relies on the activation of hair follicle stem cells and their subsequent proliferation and differentiation. Stem cell function depends on finely tuned interactions of signaling molecules and transcription factors, which are not well defined in dogs. We performed transcriptome profiling on skin biopsies to analyze altered molecular pathways in alopecia X...
2017: PloS One
https://www.readbyqxmd.com/read/29064078/defective-wnt3-expression-by-testicular-sertoli-cells-compromise-male-fertility
#10
Sayon Basu, Satya Pal Arya, Abul Usmani, Bhola Shankar Pradhan, Rajesh Kumar Sarkar, Nirmalya Ganguli, Mansi Shukla, Kamal Mandal, Surendra Singh, Kanchan Sarda, Subeer S Majumdar
Testicular Sertoli cells make a niche for the division and differentiation of germ cells. Sertoli cells respond to increased follicle-stimulating hormone (FSH) and testosterone (T) levels at the onset of puberty by producing paracrine factors which affect germ cells and trigger robust onset of spermatogenesis. Such paracrine support to germ cells is absent during infancy, despite Sertoli cells being exposed to high FSH and T within the infant testis. This situation is similar to certain cases of male idiopathic infertility where post-pubertal Sertoli cells fail to support germ cell division and differentiation in spite of endogenous or exogenous hormonal support...
October 24, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29046359/androgens-trigger-different-growth-responses-in-genetically-identical-human-hair-follicles-in-organ-culture-that-reflect-their-epigenetic-diversity-in-life
#11
Benjamin H Miranda, Matthew R Charlesworth, Desmond J Tobin, David T Sharpe, Valerie A Randall
Male sex hormones-androgens-regulate male physique development. Without androgen signaling, genetic males appear female. During puberty, increasing androgens harness the hair follicle's unique regenerative ability to replace many tiny vellus hairs with larger, darker terminal hairs (e.g., beard). Follicle response is epigenetically varied: some remain unaffected (e.g., eyelashes) or are inhibited, causing balding. How sex steroid hormones alter such developmental processes is unclear, despite high incidences of hormone-driven cancer, hirsutism, and alopecia...
October 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29045906/ctla-4-pd-1-memory-cd4-t-cells-critically-contribute-to-viral-persistence-in-antiretroviral-therapy-suppressed-siv-infected-rhesus-macaques
#12
Colleen S McGary, Claire Deleage, Justin Harper, Luca Micci, Susan P Ribeiro, Sara Paganini, Leticia Kuri-Cervantes, Clarisse Benne, Emily S Ryan, Robert Balderas, Sherrie Jean, Kirk Easley, Vincent Marconi, Guido Silvestri, Jacob D Estes, Rafick-Pierre Sekaly, Mirko Paiardini
Antiretroviral therapy (ART) suppresses viral replication in HIV-infected individuals but does not eliminate the reservoir of latently infected cells. Recent work identified PD-1(+) follicular helper T (Tfh) cells as an important cellular compartment for viral persistence. Here, using ART-treated, SIV-infected rhesus macaques, we show that CTLA-4(+)PD-1(-) memory CD4(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut, and contained replication-competent and infectious virus...
October 17, 2017: Immunity
https://www.readbyqxmd.com/read/29036567/extra-pituitary-expressed-fsh-is-it-physiologically-important
#13
Anushka Jayaraman, T Rajendra Kumar
Pituitary gonadotropes synthesize and secrete follicle-stimulating hormone (FSH). FSH is a heterodimer that consists of an α-and a β-subunit. The α - subunit is common to other pituitary and placental glycoprotein hormones and the β-subunit is the hormone/receptor specific subunit. Although the pituitary is the main tissue that accounts for circulating hormone, previous and recent reports indicate extra-pituitary sources of FSH production including mouse gonads, human stomach, prostate, umbilical cord vein endothelial cells, uterine myometrium, placenta and chicken abdominal adipose tissue...
September 20, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29035370/natural-killer-cells-migrate-into-and-control-simian-immunodeficiency-virus-replication-in-lymph-node-follicles-in-african-green-monkeys
#14
Nicolas Huot, Beatrice Jacquelin, Thalia Garcia-Tellez, Philippe Rascle, Mickaël J Ploquin, Yoann Madec, R Keith Reeves, Nathalie Derreudre-Bosquet, Michaela Müller-Trutwin
Natural killer (NK) cells play an essential role in antiviral immunity, but knowledge of their function in secondary lymphoid organs is incomplete. Lymph node follicles constitute a major viral reservoir during infections with HIV-1 and simian immunodeficiency virus of macaques (SIVmac). In contrast, during nonpathogenic infection with SIV from African green monkeys (SIVagm), follicles remain generally virus free. We show that NK cells in secondary lymphoid organs from chronically SIVagm-infected African green monkeys (AGMs) were frequently CXCR5(+) and entered and persisted in lymph node follicles throughout the follow-up (240 d post-infection)...
November 2017: Nature Medicine
https://www.readbyqxmd.com/read/29030488/long-lived-innate-il-17-producing-%C3%AE-%C3%AE-t-cells-modulate-antimicrobial-epithelial-host-defense-in-the-colon
#15
Abdul Rashid Bin Mohammad Muzaki, Irene Soncin, Yolanda Aphrilia Setiagani, Jianpeng Sheng, Piotr Tetlak, Klaus Karjalainen, Christiane Ruedl
Intestinal IL-17-producing cells, including Th17, γ/δ T, and innate lymphoid cells, are differentially distributed along the gastrointestinal tract. In this study, we show that the gut IL-17-producing γ/δ T (γ/δ T17) cells develop before birth and persist in the tissue as long-lived cells with minimal turnover. Most colon γ/δ T17 cells express, together with Vγ4 and CCR6, the scavenger receptor 2 and are mainly restricted to innate lymphoid follicles in the colon. Colon γ/δ T cells in mice that lack conventional dendritic cells 2 produced increased amounts of IL-17 with concomitant heightened epithelial antimicrobial response, such as the C-type lectins Reg3γ and Reg3β...
October 13, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29025092/heat-stress-induces-autophagy-in-pig-ovaries-during-follicular-development
#16
Benjamin J Hale, Candice L Hager, Jacob T Seibert, Joshua T Selsby, Lance H Baumgard, Aileen F Keating, Jason W Ross
Hyperthermia or heat stress (HS) occurs when heat dissipation mechanisms are overwhelmed by external and internal heat production. Hyperthermia negatively affects reproduction and potentially compromises oocyte integrity and reduces developmental competence of ensuing embryos. Autophagy is the process by which cells recycle energy through the reutilization of cellular components and is activated by a variety of stressors. Study objectives were to characterize autophagy-related proteins in the ovary following cyclical HS during the follicular phase...
September 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28994787/in-situ-mhc-tetramer-staining-and-quantitative-analysis-to-determine-the-location-abundance-and-phenotype-of-antigen-specific-cd8-t-cells-in-tissues
#17
Shengbin Li, Gwantwa Mwakalundwa, Pamela J Skinner
T cells are critical to many immunological processes, including detecting and eliminating virus-infected cells, preventing autoimmunity, assisting in B-cell and plasma-cell production of antibodies, and detecting and eliminating cancer cells. The development of MHC-tetramer staining of antigen-specific T cells analyzed by flow cytometry has revolutionized our ability to study and understand the immunobiology of T cells. While extremely useful for determining the quantity and phenotype of antigen-specific T cells, flow cytometry cannot determine the spatial localization of antigen-specific T cells to other cells and structures in tissues, and current disaggregation techniques to extract the T cells needed for flow cytometry have limited effectiveness in non-lymphoid tissues...
September 22, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28992198/analysing-the-dynamics-of-a-model-for-alopecia-areata-as-an-autoimmune-disorder-of-hair-follicle-cycling
#18
Atanaska Dobreva, Ralf Paus, N G Cogan
Alopecia areata (AA) is a CD8$^{+}$ T cell-dependent autoimmune disease that disrupts the constantly repeating cyclic transformations of hair follicles (HFs). Among the three main HF cycle stages-growth (anagen), regression (catagen) and relative quiescence (telogen)-only anagen HFs are attacked and thereby forced to prematurely enter into catagen, thus shortening active hair growth substantially. After having previously modelled the dynamics of immune system components critically involved in the disease development (Dobreva et al...
August 7, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/28988659/dynamics-of-oogenesis-in-ghost-shrimp-callichirus-major-crustacea-axiidea-a-morphofunctional-and-histochemical-study
#19
Tugstênio L Souza, Adriane A Braga, Laura S López-Greco, Erika T Nunes
Callichirus major, popularly known as ghost shrimp, is a species of great importance in the fishing industry, because of its use as live bait. This study aimed to describe the different stages of the developing ovaries in C. major. Shrimps were collected along the Corujão beach, Piuma, Brazil (20°50'41.6"S 40°44'15.7"W), and the gonads were dissected for histological and histochemical analysis. The ovary consists of two elongated filaments covered by a connective tissue that divides the organ into lobules, where somatic and germ cells are found...
October 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28986927/effects-of-phyto-oestrogen-quercetin-on-productive-performance-hormones-reproductive-organs-and-apoptotic-genes-in-laying-hens
#20
J X Yang, M T Chaudhry, J Y Yao, S N Wang, B Zhou, M Wang, C Y Han, Y You, Y Li
Quercetin, a polyphenolic flavonoid with diverse biological activities including anti-inflammatory and antiviral, inhibits lipid peroxidation, prevents oxidative injury and cell death. The purpose of the research was to investigate the effect of quercetin on productive performance, reproductive organs, hormones and apoptotic genes in laying hens between 37 and 45 weeks of age, because of the structure and oestrogenic activities similar to 17β-oestradiol. The trial was conducted using 240 Hessian laying hens (37 weeks old), housed in wire cages with two hens in each cage...
October 6, 2017: Journal of Animal Physiology and Animal Nutrition
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