keyword
https://read.qxmd.com/read/38007395/resazurin-microplate-test-method-for-rapid-determination-of-colistin-resistance-in-carbapenem-resistant-acinetobacter-baumanii-isolates
#21
JOURNAL ARTICLE
Kubra Yildirim, Ece Simsek, Orhan Kocak, Serhat Bozkurt, Ozlem Koyuncu Ozyurt, Ahmet Yilmaz Coban
BACKGROUND: Colistin-resistant Acinetobacter baumannii isolates are extremely important pathogens for hospital-acquired infections. OBJECTIVE: To investigate the effectiveness of the resazurin microplate assay (REMA) for the rapid determination of colistin resistance. METHODS: Susceptibility for colistin was investigated in vitro by the broth microdilution method (BMD) and the resazurin microplate assay (REMA) on 106 carbapenem-resistant Acinetobacter baumannii isolates...
November 25, 2023: Laboratory Medicine
https://read.qxmd.com/read/37996620/quaternary-ammonium-based-coating-of-textiles-is-effective-against-bacteria-and-viruses-with-a-low-risk-to-human-health
#22
JOURNAL ARTICLE
Philipp Meier, Pietro Clement, Stefanie Altenried, Giacomo Reina, Qun Ren, Roland Züst, Olivier Enger, Francis Choi, Nikolaus Nestle, Ted Deisenroth, Peter Neubauer, Peter Wick
While the global healthcare system is slowly recovering from the COVID-19 pandemic, new multi-drug-resistant pathogens are emerging as the next threat. To tackle these challenges there is a need for safe and sustainable antiviral and antibacterial functionalized materials. Here we develop an 'easy-to-apply' procedure for the surface functionalization of textiles, rendering them antiviral and antibacterial and assessing the performance of these textiles. A metal-free quaternary ammonium-based coating was applied homogeneously and non-covalently to hospital curtains...
November 23, 2023: Scientific Reports
https://read.qxmd.com/read/37970087/evaluation-of-different-methods-for-in-vitro-susceptibility-testing-of-colistin-in-carbapenem-resistant-gram-negative-bacilli
#23
JOURNAL ARTICLE
Bidyutprava Rout, Sumesh Kumar Dash, Kundan Kumar Sahu, Birasen Behera, Ira Praharaj, Sarita Otta
INTRODUCTION: The increasing antibiotic resistance like the advent of carbapenem resistant Enterobactarales (CRE), Carbapenem Resistant Acinetobacter baumanii (CRAB), and Carbapenem Resistant Pseudomonas aeruginosa (CRPA) has led to to the use of toxic and older drugs like colistin for these organisms. But worldwide there is an increase in resistance even to colistin mediated both by chromosomes and plasmids. This necessitates accurate detection of resistance. This is impeded by the unavailability of a user-friendly phenotypic methods for use in routine clinical microbiology practice...
2023: Access microbiology
https://read.qxmd.com/read/37967634/bacteriophages-status-quo-and-emerging-trends-toward-one-health-approach
#24
REVIEW
Rachel Samson, Mahesh Dharne, Krishna Khairnar
The alarming rise in antimicrobial resistance (AMR) among the drug-resistant pathogens has been attributed to the ESKAPEE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, Enterobacter sp., and Escherichia coli). Recently, these AMR microbes have become difficult to treat, as they have rendered the existing therapeutics ineffective. Thus, there is an urgent need for effective alternatives to lessen or eliminate the current infections and limit the spread of emerging diseases under the "One Health" framework...
November 13, 2023: Science of the Total Environment
https://read.qxmd.com/read/37946633/blue-light-potentiates-antibiotics-in-bacteria-via-parallel-pathways-of-hydroxyl-radical-production-and-enhanced-antibiotic-uptake
#25
JOURNAL ARTICLE
Leon G Leanse, Carolina Dos Anjos, Kylie Ryan Kaler, Jie Hui, Jeffrey M Boyd, David C Hooper, R Rox Anderson, Tianhong Dai
In the age of antimicrobial resistance, the urgency by which novel therapeutic approaches need to be introduced into the clinical pipeline has reached critical levels. Antimicrobial blue light (aBL), as an alternative approach, has demonstrated promise as a stand-alone therapeutic method, albeit with a limited window of antimicrobial activity. Work by others indicates that treatment with antibiotics increases the production of reactive oxygen species (ROS) which may, in part, contribute to the bactericidal effects of antibiotics...
November 9, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/37909295/copper-forms-a-ppii-helix-like-structure-with-the-catalytic-domains-of-bacterial-zinc-metalloproteases
#26
JOURNAL ARTICLE
Paulina Potok, Arian Kola, Daniela Valensin, Merce Capdevila, Sławomir Potocki
The rapid spread of antibiotic-resistant bacteria continuously raises concerns about the future ineffectiveness of current antimicrobial treatments against infectious diseases. To address this problem, new therapeutic strategies and antimicrobial drugs with unique modes of action are urgently needed. Inhibition of metalloproteases, bacterial virulence factors, is a promising target for the development of antibacterial treatments. In this study, the interaction among Zn(II), Cu(II), and the metal-binding domains of two metalloproteases, AprA ( Pseudomonas aureginosa ) and CpaA ( Acinetobacter baumanii ), was investigated...
November 1, 2023: Inorganic Chemistry
https://read.qxmd.com/read/37908764/risk-factors-and-outcome-associated-with-coinfection-with-carbapenem-resistant-klebsiella-pneumoniae-and-carbapenem-resistant-pseudomonas-aeruginosa-or-acinetobacter-baumanii-a-descriptive-analysis
#27
JOURNAL ARTICLE
Anthony Sophonsri, Corey Kelsom, Mimi Lou, Paul Nieberg, Annie Wong-Beringer
BACKGROUND: Nearly 30% of patients infected with carbapenem-resistant Klebsiella pneumoniae (CRKP) were previously shown to be coinfected with carbapenem-resistant Pseudomonas aeruginosa (CRPA) or Acinetobacter baumannii (CRAB). Infections caused by multiple carbapenem-resistant pathogens present significant challenge to infection control and therapeutic management. The study objective was to identify risk factors for acquisition of multiple carbapenem-resistant pathogens and associated outcomes...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/37896256/analysis-of-pathogens-of-urinary-tract-infections-associated-with-indwelling-double-j-stents-and-their-susceptibility-to-globularia-alypum
#28
JOURNAL ARTICLE
Khaireddine Bouassida, Manel Marzouk, Sahar Nouir, Rim Ghammem, Wissal Sahtout, Meriam Ghardallou, Neila Fathallah, Jalel Boukadida, Mehdi Jaidane, Raoudha Slim, Amira Zaïri
Ureteral double-J stents are frequently used to prevent urinary obstruction. They can develop bacterial colonization and encrustation, which leads to persistent infections that seldom respond to antibiotic treatment. Thus, the goal of this study was to evaluate the local spectrum of bacterial pathogens and their susceptibility to natural compounds. A total of 59 double-J ureteral stents from 59 consecutive patients were examined. The samples were inoculated on agar culture mediums. Extracts of Globularia alypum L...
October 19, 2023: Pharmaceutics
https://read.qxmd.com/read/37885560/acinetobacter-baumannii-early-onset-sepsis-after-home-delivery-into-toilet-water
#29
Patrícia Sousa, Beatriz Sousa, Francisca Calheiros-Trigo, Mariana Martins, Clara Paz-Dias
Early-onset sepsis (EOS) is an important cause of morbidity and mortality in newborns, usually caused by pathogens acquired intrapartum. We present the case of a term neonate born by home delivery in the toilet, after an unsupervised pregnancy. He developed a culture-proven early-onset sepsis caused by Acinetobacter baumannii . This was the first case of neonatal sepsis by this pathogen in our unit. The microorganism was susceptible to all antibiotics tested. The neonate was treated empirically with ampicillin and cefotaxime and completed 21 days of directed therapy with meropenem, as meningitis could not be excluded...
September 2023: Curēus
https://read.qxmd.com/read/37885265/rational-design-of-hybrid-peptide-with-high-antimicrobial-property-derived-from-melittin-and-lasioglossin
#30
JOURNAL ARTICLE
Somayeh Nabizadeh, Leila Rahbarnia, Jamileh Nowrozi, Safar Farajnia, Farzaneh Hosseini
Hybridization of Antimicrobial peptides (AMPs) with unique abilities is now considered to improve AMPs' function as promising therapeutic candidates. In the current research, Lasioglossin (LL-III) with a high antimicrobial effect on Acinetobacter (A.) baumanni and Melittin with a high antimicrobial effect against Staphylococcus (S.) aureus were selected for designing a hybrid peptide with modified properties. In the present study, a hybrid peptide with modified properties was designed. Molecular dynamic (MD) and coarse-grained (CG) simulations were done to evaluate the stability and interaction of the hybrid peptide with related membrane models...
October 26, 2023: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/37846592/antibiotic-therapy-for-nonfermenting-gram-negative-bacilli-infections-future-perspectives
#31
REVIEW
Matteo Bassetti, Nadia Castaldo, Alberto Fantin, Daniele Roberto Giacobbe, Antonio Vena
PURPOSE OF REVIEW: Serious infections caused by nonfermenting Gram-negative bacteria (NF-GNB) pose a significant challenge for clinicians due to the limited treatment options available, which are frequently associated with issues of toxicity and unfavourable pharmacokinetic profiles. The aim of this review is to provide a brief overview of the existing data concerning the ongoing development of antiinfective agents targeting NF-GNB. RECENT FINDINGS: Several agents exhibiting efficacy against NF-GNB are under clinical investigation...
December 1, 2023: Current Opinion in Infectious Diseases
https://read.qxmd.com/read/37813349/-multidrug-resistant-bacterial-colonisation-in-ukrainian-war-injuries-a-need-for-multimodal-therapy
#32
JOURNAL ARTICLE
Wolfram Demmer, Irene Mesas Aranda, Paul Severin Wiggenhauser, David Braig, Fabian Gilbert, Riccardo Giunta
This case report describes the interdisciplinary treatment of a complex shrapnel injury to the right femur of an 18-year-old Ukrainian soldier. This open multifragmentary fractur of the femur with a large bone defect, soft tissue damage and osteomyelitis was complicated by several multidrug-resistant bacteria, including Acinetobacter baumanii, which could not be eradicated by antibiotic treatment. Sterility was only achieved by multiple radical debridement and by negative pressure wound therapy with instillation (NPWTi) using hypochlorous acid...
October 9, 2023: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://read.qxmd.com/read/37760709/bibliometric-analysis-of-global-research-output-on-antimicrobial-resistance-among-pneumonia-pathogens-2013-2023
#33
JOURNAL ARTICLE
Nurgul Ablakimova, Gaziza A Smagulova, Svetlana Rachina, Aigul Z Mussina, Afshin Zare, Nadiar M Mussin, Asset A Kaliyev, Reza Shirazi, Nader Tanideh, Amin Tamadon
Antimicrobial resistance (AMR) is a pressing global concern, posing significant challenges to the effective treatment of infections, including pneumonia. This bibliometric analysis aims to investigate the research output on AMR among pneumonia pathogens from 2013 to 2023. Data were extracted from the Web of Science Core Collection (WOS-CC) using an inclusive search strategy. The analysis included 152 relevant studies published in 99 different sources, involving 988 authors and yielding an average of 16.33 citations per document over the past decade...
September 6, 2023: Antibiotics
https://read.qxmd.com/read/37705878/quality-control-phytochemical-profile-and-biological-activities-of-crataegus-monogyna-jacq-and-crataegus-laciniata-ucria-fruits-aqueous-extracts
#34
JOURNAL ARTICLE
Fatima Zahrae Radi, Noureddine Bencheikh, Hammou Anarghou, Mohamed Bouhrim, Ali S Alqahtani, Mohammed F Hawwal, Omar M Noman, Mohamed Bnouham, Touriya Zair
The current study aimed to evaluate the phytochemical composition, quality control, and antioxidant, antibacterial, antifungal, antihyperglycemic activities, and toxicity assessment of Crataegus monogyna Jacq ( C. monogyna ) and Crataegus laciniata Ucria ( C. laciniata) fruits aqueous extracts. The quality control of the plant material revealed that it is free of heavy metals and the acidity and ash parameters comply with international standards. HPLC-DAD analysis revealed the presence of eight phenolic compounds in the C...
October 2023: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/37630455/microbiological-analysis-of-surgeons-hands-in-a-public-hospital-in-s%C3%A3-o-luis-maranh%C3%A3-o-state-brazil-a-cross-sectional-study
#35
JOURNAL ARTICLE
Artur Serra Neto, Sirlei G Marques, Maria Rosa Q Bomfim, Silvio G Monteiro, Rosangela C de Souza, Rodolfo A Nunes
Antisepsis of the hands of medical personnel is one of the most important steps in the process of patient care, since direct contact can cause the cross-transfer of potentially pathogenic microorganisms at surgical sites. This study aimed to analyze the prevalence of microorganisms on the hands of 131 surgeons in a university hospital before the surgical procedure. Swabs were collected from each clinician's hands before and after handwashing. The samples were placed in a transport medium and immediately delivered to a private clinical analysis laboratory from São Luis-Maranhão...
July 27, 2023: Microorganisms
https://read.qxmd.com/read/37627683/antibiotic-therapy-strategies-for-treating-gram-negative-severe-infections-in-the-critically-ill-a-narrative-review
#36
REVIEW
Alberto Corona, Vincenzo De Santis, Andrea Agarossi, Anna Prete, Dario Cattaneo, Giacomina Tomasini, Graziella Bonetti, Andrea Patroni, Nicola Latronico
INTRODUCTION: Not enough data exist to inform the optimal duration and type of antimicrobial therapy against GN infections in critically ill patients. METHODS: Narrative review based on a literature search through PubMed and Cochrane using the following keywords: "multi-drug resistant (MDR)", "extensively drug resistant (XDR)", "pan-drug-resistant (PDR)", "difficult-to-treat (DTR) Gram-negative infection," "antibiotic duration therapy", "antibiotic combination therapy" "antibiotic monotherapy" "Gram-negative bacteremia", "Gram-negative pneumonia", and "Gram-negative intra-abdominal infection"...
July 31, 2023: Antibiotics
https://read.qxmd.com/read/37608868/change-in-antimicrobial-therapy-based-on-bronchoalveolar-lavage-data-improves-outcomes-in-icu-patients-with-suspected-pneumonia
#37
JOURNAL ARTICLE
Bharti Chogtu, Vrinda Mariya Elenjickal, Dharma U Shetty, Mahsheeba Asbin, Vasudeva Guddattu, Rahul Magazine
Flexible bronchoscopy (FB) is often performed in critically ill patients with suspected pneumonia. It is assumed that there will be an association with improved outcomes when bronchoalveolar lavage (BAL) data lead to a change in antimicrobial therapy. Methods. This study included a retrospective cohort of intensive care unit (ICU) patients who underwent FB for a diagnosis of suspected pneumonia. The study compared the outcome of patients in whom antimicrobial modification was carried out based on BAL reports versus those in whom it was not carried out...
2023: Critical Care Research and Practice
https://read.qxmd.com/read/37596791/treating-necrotizing-fasciitis-patients-at-the-topmost-referral-hospital-in-west-java-indonesia-6%C3%A2-years-experience
#38
JOURNAL ARTICLE
Hardisiswo Soedjana, Sitha Christine, Fransisca Sisca
Necrotizing fasciitis is a progressive and rare disease, with high potential to be life-threatening because of its potential for systemic toxicity. Characterized by fascial infection, it is often followed by systemic toxicity, such as septic shock and multi-organ failure. The aim of this study is to establish reliable data on the treatment of necrotizing fasciitis patients at the topmost referral hospital in West Java, Indonesia. We collected medical record data from January 2015 to December 2021 at Rumah Sakit Umum Pusat Dr...
August 18, 2023: International Wound Journal
https://read.qxmd.com/read/37564783/assesment-of-polyphenolic-compounds-against-biofilms-produced-by-clinical-acinetobacter-baumannii-strains-using-in-silico-and-in-vitro-models
#39
JOURNAL ARTICLE
Laraib Mumtaz, Arshad Farid, Suliman Yousef Alomar, Naushad Ahmad, Asif Nawaz, Saadia Andleeb, Adnan Amin
Several types of microbial infections are caused by Acinetobacter baumanii that has developed resistance to antimicrobial agents . We therefore investigated the role of plant polyphenols against A. baumannii using in silico and in vitro models. The clinical strains of A. baumannii were investigated for determination of resistance pattern and resistance mechanisms including efflux pump, extended spectrum beta lactamase, phenotype detection of AmpC production, and Metallo-β-lactamase. The polyphenolic compounds were docked against transcription regulator BfmR (PDB ID 6BR7) and antimicrobial, antibiofilm, and anti-quorum sensing activities were performed...
September 2023: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/37512883/mortality-due-to-multidrug-resistant-gram-negative-bacteremia-in-an-endemic-region-no-better-than-a-toss-of-a-coin
#40
JOURNAL ARTICLE
Olga Tsachouridou, Dimitrios Pilalas, Sideris Nanoudis, Athanasios Antoniou, Isidora Bakaimi, Theofilos Chrysanthidis, Konstantinos Markakis, Angeliki Kassomenaki, Paraskevi Mantzana, Efthymia Protonotariou, Lemonia Skoura, Symeon Metallidis
The incidence of multidrug-resistant (MDR) bloodstream infections (BSIs) is associated with high morbidity and mortality. Little evidence exists regarding the epidemiology of BSIs and the use of appropriate empirical antimicrobial therapy in endemic regions. Novel diagnostic tests (RDTs) may facilitate and improve patient management. Data were assessed from patients with MDR Gram-negative bacteremia at a university tertiary hospital over a 12-month period. In total, 157 episodes of MDR Gram-negative BSI were included in the study...
June 30, 2023: Microorganisms
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