Padam Singh, Arun Kumar, Pankaj Sharma, Saurabh Chugh, Ashish Kumar, Nidhi Sharma, Sonu Gupta, Manisha Singh, Saqib Kidwai, Jishnu Sankar, Neha Taneja, Yashwant Kumar, Rohan Dhiman, Dinesh Mahajan, Ramandeep Singh
New drugs with novel mechanisms of action are urgently needed to tackle the issue of drug-resistant tuberculosis. Here, we have performed phenotypic screening using the Pathogen Box library obtained from the Medicines for Malaria Venture against Mycobacterium tuberculosis in vitro . We have identified a pyridine carboxamide derivative, MMV687254, as a promising hit. This molecule is specifically active against M. tuberculosis and Mycobacterium bovis Bacillus Calmette-Guérin ( M. bovis BCG) but inactive against Enterococcus faecalis , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumanii , Pseudomonas aeruginosa , and Escherichia coli pathogens...
January 9, 2024: Antimicrobial Agents and Chemotherapy