keyword
https://read.qxmd.com/read/38530969/characterization-of-the-diversity-of-type-iv-secretion-system-encoding-plasmids-in-acinetobacter
#1
JOURNAL ARTICLE
Farah Nasser, Avery Gaudreau, Shareefah Lubega, Arvin Zaker, Xuhua Xia, Arvind S Mer, Vanessa M D'Costa
The multi-drug resistant pathogen Acinetobacter baumannii has gained global attention as an important clinical challenge. Owing to its ability to survive on surfaces, its capacity for horizontal gene transfer, and its resistance to front-line antibiotics, A. baumannii has established itself as a successful pathogen. Bacterial conjugation is a central mechanism for pathogen evolution. The epidemic multidrug-resistant A. baumannii ACICU harbours a plasmid encoding a Type IV Secretion System (T4SS) with homology to the E...
December 2024: Emerging Microbes & Infections
https://read.qxmd.com/read/38506388/post-trauma-acinetobacter-baumanii-meningitis-treatment-approach
#2
Cem Erdoğan, Zeynep Betul Balcioglu, Isa Seida, Denız Kizilaslan
A. baumannii, which is said to be associated with nosocomial infections is considered a significant mortality risk if not adequately addressed. A. baumannii infections typically occur in the aftermath of surgery or trauma. Our patient developed complicated A. baumannii meningitis with lateral ventriculitis and a lumbar abscess post surgery after suffering from a fall. The patient was treated with a 21-day regimen of intrathecally administered colistin and polymyxin B. Following this therapeutic period, the patient's condition improved, ultimately leading to successful recovery and subsequent discharge...
March 2024: Turkish Journal of Trauma & Emergency Surgery: TJTES
https://read.qxmd.com/read/38432452/polydopamine-based-nano-adjuvant-as-a-promising-vaccine-carrier-induces-significant-immune-responses-against-acinetobacter-baumannii-associated-pneumonia
#3
JOURNAL ARTICLE
Samira Sabzi, Mehri Habibi, Farzad Badmasti, Shahla Shahbazi, Mohammad Reza Asadi Karam, Mehdi Farokhi
The objective of this study was to assess the effectiveness of polydopamine nanoparticles (PDANPs) as a delivery system for intranasal antigen administration to prevent Acinetobacter baumannii (A. baumannii)-associated pneumonia. In the in vitro phase, the conserved outer membrane protein 22 (Omp22)-encoding gene of A. baumannii was cloned, expressed, and purified, resulting in the production of recombinant Omp22 (rOmp22), which was verified using western blot. PDANPs were synthesized using dopamine monomers and loaded with rOmp22 through physical adsorption...
March 1, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38400950/colistin-resistance-in-carbapenem-non-susceptible-acinetobacter-baumanii-in-a-tertiary-care-hospital-in-india-clinical-characteristics-antibiotic-susceptibility-and-molecular-characterization
#4
JOURNAL ARTICLE
Bidyut Prava Rout, Sumesh Kumar Dash, Sarita Otta, Birasen Behera, Ira Praharaj, Kundan Kumar Sahu
INTRODUCTION: Acinetobacter baumanii (AB) is a bacterium of concern in the hospital setup due to its ability to thrive in unfavorable conditions and the rapid emergence of antibiotic resistance. Carbapenem resistance in this organism is disheartening, further clouded by the emergence of colistin resistance. AIM: The present prospective study aims to note the epidemiology, molecular profile, and clinical outcome of patients with colistin resistance AB infections in a multispecialty tertiary care setup in Odisha, Eastern India...
February 24, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38329335/epidemiological-clinical-and-laboratory-characteristics-of-human-granulocytic-anaplasmosis-in-north-india
#5
JOURNAL ARTICLE
E V Vinayaraj, Chandan Kumar Thakur, Preeti Negi, K Sreenath, Priyanka Upadhyay, Nishant Verma, Bimal Kumar Das, S K Kabra, Naveet Wig, Rama Chaudhry
Human granulocytic anaplasmosis (HGA) is an emerging, rickettsial tick-borne disease caused by Anaplasma phagocytophilum . Sero-epidemiological data demonstrate that this pathogen has a worldwide distribution. The diagnosis of HGA requires a high index of clinical suspicion, even in endemic areas. In recent years, HGA has increasingly been reported from Asia and described in China, Japan, and Korea. We serologically and molecularly screened 467 patients with clinical suspicion of Anaplasmosis. The present study describes the epidemiology, clinical, and laboratory details of 6 confirmed and 43 probable cases of human granulocytic anaplasmosis...
February 8, 2024: Journal of Clinical Microbiology
https://read.qxmd.com/read/38325427/biodegradation-of-used-engine-oil-by-lead-resistant-bacteria-acinetobacter-sp-har20-newly-isolated-from-harbour-seawater-oran-algeria
#6
JOURNAL ARTICLE
Soumia Nil, Sidi-Mohammed El-Amine Abi-Ayad
This paper focuses on the degrading capacity of various hydrocarbon fractions of used engine oils (UEO) by marine microorganisms, as well as the biosorption of heavy metals. A bacterial strain with a significant capability to grow on UEO as a sole source of carbon and energy was isolated from harbour seawater samples (Oran, Algeria). The molecular identification by sequencing the 16S rDNA gene revealed that the bacterium matched Acinetobacter baumanii with 96.84% homology similarity. Thus, strain HAR20 was named Acinetobacter sp...
February 7, 2024: Environmental Technology
https://read.qxmd.com/read/38263063/risk-factors-for-transmission-of-carbapenem-resistant-acinetobacter-baumannii-in-outbreak-situations-results-of-a-case-control-study
#7
JOURNAL ARTICLE
Beate Schlosser, Beate Weikert, Giovanni-Battista Fucini, Britta Kohlmorgen, Axel Kola, Anna Weber, Norbert Thoma, Michael Behnke, Frank Schwab, Petra Gastmeier, Christine Geffers, Seven Johannes Sam Aghdassi
BACKGROUND: An increase in patients with multidrug-resistant organisms and associated outbreaks during the COVID-19 pandemic have been reported in various settings, including low-endemic settings. Here, we report three distinct carbapenem-resistant Acinetobacter baumannii (CRAB) outbreaks in five intensive care units of a university hospital in Berlin, Germany during the COVID-19 pandemic. METHODS: A case-control study was conducted with the objective of identifying risk factors for CRAB acquisition in outbreak situations...
January 23, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38258766/sulbactam-durlobactam-a-novel-drug-for-the-treatment-of-multidrug-resistant-acinetobacter-baumannii-infections-a-systematic-review
#8
JOURNAL ARTICLE
Hemasri Velmurugan, Sajitha Venkatesan, Hadush Negash Meles, Pugazhenthan Thangaraju, Krishnapriya Neelambaram
BACKGROUND: Sulbactam-durlobactam (SUL-DUR) has been tested in vitro for its ability to gen- erate resistance in clinical isolates of Acinetobacter species. According to prior studies, combining durlobac- tam with sulbactam causes sulbactam-resistant isolates to become more active and revert to susceptibility. We aimed to conduct a systematic review of the in vitro activity of SUL-DUR on A. baumannii (Ab) iso- lates, including carbapenem-resistant A. baumannii (CRAb), to provide an overview for physicians dealing with Ab infections...
January 22, 2024: Infectious Disorders Drug Targets
https://read.qxmd.com/read/38226398/efficacy-of-disinfection-procedures-to-reduce-acinetobacter-baumanii-bla-oxa-23-contamination-rate-of-needleless-connectors-an-in-vitro-study
#9
JOURNAL ARTICLE
C Biazus-Dalcin, T C M Sincero, C P Zamparette, D C Tartari, S de Souza, T L Silva, A Tomazoni, P K Rocha
AIM: This study aimed to verify the efficacy of disinfection procedures to reduce Acinetobacter baumannii bla OXA-23 bacterial load in needleless connectors that had been experimentally contaminated. METHODS: Two-way intermediate extender's hub and needle-free valve were contaminated with Acinetobacter baumannii bla OXA-23 . To disinfect them, the following procedures were carried out: sterile gauze with 70% ethanol, sterile gauze with Incidin®, and 70% isopropyl alcohol single-use cap, with eight times friction for 10 s, followed by 5 s drying time...
March 2024: Infection prevention in practice
https://read.qxmd.com/read/38193667/identification-and-optimization-of-pyridine-carboxamide-based-scaffold-as-a-drug-lead-for-mycobacterium-tuberculosis
#10
JOURNAL ARTICLE
Padam Singh, Arun Kumar, Pankaj Sharma, Saurabh Chugh, Ashish Kumar, Nidhi Sharma, Sonu Gupta, Manisha Singh, Saqib Kidwai, Jishnu Sankar, Neha Taneja, Yashwant Kumar, Rohan Dhiman, Dinesh Mahajan, Ramandeep Singh
New drugs with novel mechanisms of action are urgently needed to tackle the issue of drug-resistant tuberculosis. Here, we have performed phenotypic screening using the Pathogen Box library obtained from the Medicines for Malaria Venture against Mycobacterium tuberculosis in vitro . We have identified a pyridine carboxamide derivative, MMV687254, as a promising hit. This molecule is specifically active against M. tuberculosis and Mycobacterium bovis Bacillus Calmette-Guérin ( M. bovis BCG) but inactive against Enterococcus faecalis , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumanii , Pseudomonas aeruginosa , and Escherichia coli pathogens...
January 9, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38192910/promoting-patient-safety-exploring-device-associated-healthcare-infections-and-antimicrobial-susceptibility-pattern-in-a-multidisciplinary-intensive-care-units
#11
JOURNAL ARTICLE
Neeta Gade, Ranga Burri, Akkilagunta Sujiv, Meena Mishra, B E Pradeep, Harish Debaje, Tejswini Sable, Amandeep Kaur
INTRODUCTION: Device-associated healthcare infections are among the prevailing threats to patient safety worldwide. They constitute the third most common adverse event during healthcare delivery, resulting in heightened morbidity, mortality, and healthcare costs. Patients in intensive care units (ICUs) are at increased risk for device-associated healthcare infections. Focused active surveillance is a crucial measure for assessing the prevalence of healthcare-associated infections and controlling the transmission of pathogens, ultimately contributing to the establishment of quality outcome indicators...
December 2023: Curēus
https://read.qxmd.com/read/38156310/association-between-pneumonia-development-and-virulence-gene-expression-in-carbapenem-resistant-acinetobacter-baumannii-isolated-from-clinical-specimens
#12
JOURNAL ARTICLE
Ji Yun Bae, Ina Yun, Kang Il Jun, Chung-Jong Kim, Miae Lee, Hee Jung Choi
We investigated the virulence gene expression of carbapenem-resistant Acinetobacter baumanii (CRAB) isolated from the respiratory samples of patients with CRAB pneumonia and those with CRAB colonization to identify the virulence genes contributing to CRAB pneumonia's development and mortality. Patients with CRAB identified from respiratory specimens were screened at a tertiary university hospital between January 2018 and January 2019. Patients were classified into CRAB pneumonia or CRAB colonization groups according to predefined clinical criteria...
2023: Canadian Journal of Infectious Diseases & Medical Microbiology
https://read.qxmd.com/read/38139363/the-dynamics-of-oxa-23-%C3%AE-lactamase-from-acinetobacter-baumannii
#13
JOURNAL ARTICLE
Roberto Arrigoni, Andrea Ballini, Luigi Santacroce, Luigi Leonardo Palese
Antibiotic resistance is a pressing topic, which also affects β-lactam antibiotic molecules. Until a few years ago, it was considered no more than an interesting species from an academic point of view, Acinetobacter baumanii is today one of the most serious threats to public health, so much so that it has been declared one of the species for which the search for new antibiotics, or new ways to avoid its resistance, is an absolute priority according to WHO. Although there are several molecular mechanisms that are responsible for the extreme resistance of A...
December 15, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38116362/catheter-associated-vancomycin-resistant-enterococcus-faecium-ventriculitis-and-multidrug-resistant-acinetobacter-baumannii-pneumonia-with-subsequent-acinetobacter-ventriculitis-a-case-report
#14
Kyle M Rei, Vedhika Reddy, Christopher Andraos, James Brazdzionis, Javed Siddiqi
Ventriculitis is associated with cerebrospinal fluid (CSF) shunts, and rare microorganisms associated with infection include vancomycin-resistant Enterococcus (VRE) faecium and Acinetobacter baumannii . Both organisms are known to cause nosocomial infections, and the emergence of multidrug-resistant (MDR) strains presents a treatment challenge. There is a lack of consensus on antimicrobial agent selection for ventriculitis involving VRE faecium or MDR A. baumannii , which are life-threatening conditions. We present a case of a 59-year-old male presenting with CSF catheter-associated VRE faecium ventriculitis and MDR A...
November 2023: Curēus
https://read.qxmd.com/read/38111598/surveillance-of-health-care-associated-infections-in-an-intensive-care-unit-at-a-tertiary-care-hospital-in-central-india
#15
JOURNAL ARTICLE
Ruchita Lohiya, Vijayshri Deotale
INTRODUCTION: Because the risk of health-care associated infections (HAIs) is high in intensive care units, and HAIs are one of the causes of morbidity and mortality and affects the overall quality of health care, the continuous monitoring of HAIs in intensive care patients is essential. AIM AND OBJECTIVES: This descriptive cross-sectional study was carried out over a period of five years in a tertiary-care teaching hospital. The aim of the study was to investigate the main and specific types of health-care associated Infections and determine the microbiological profile and antimicrobial susceptibility rates of isolates in patients with HAI...
2023: GMS Hygiene and Infection Control
https://read.qxmd.com/read/38092837/unraveling-the-genome-of-bacillus-velezensis-mep-2-18-a-strain-producing-fengycin-homologs-with-broad-antibacterial-activity-comprehensive-comparative-genome-analysis
#16
JOURNAL ARTICLE
Daniela Medeot, Analía Sannazzaro, María Julia Estrella, Gonzalo Torres Tejerizo, Bruno Contreras-Moreira, Mariano Pistorio, Edgardo Jofré
Bacillus sp. MEP2 18, a soil bacterium with high potential as a source of bioactive molecules, produces mostly C16-C17 fengycin and other cyclic lipopeptides (CLP) when growing under previously optimized culture conditions. This work addressed the elucidation of the genome sequence of MEP2 18 and its taxonomic classification. The genome comprises 3,944,892 bp, with a total of 3474 coding sequences and a G + C content of 46.59%. Our phylogenetic analysis to determine the taxonomic position demonstrated that the assignment of the MEP2 18 strain to Bacillus velezensis species provides insights into its evolutionary context and potential functional attributes...
December 13, 2023: Scientific Reports
https://read.qxmd.com/read/38069822/clinical-laboratory-profile-and-molecular-characterization-of-orientia-tsutsugamushi-among-fatal-scrub-typhus-patients-from-karnataka-india
#17
JOURNAL ARTICLE
Kiran Chunduru, Manoj A R, Subhadra Poornima, Manjunatha Hande H, Ramakrishna Devaki, George M Varghese, Kavitha Saravu
BACKGROUND: Scrub typhus is a vector-borne infection caused by the obligate intracellular organism Orientia tsutsugamushi. In some cases, scrub typhus can result in severe complications, multiorgan failure and death. OBJECTIVE: To study the clinical and laboratory profiles of patients who succumbed to scrub typhus. METHODS: A prospective cohort study was conducted from August 2019 through April 2023 on scrub typhus patients admitted to our hospital...
December 9, 2023: Infectious Diseases
https://read.qxmd.com/read/38044610/-treatment-strategy-of-congenital-tracheal-stenosis-associated-with-non-vascular-ring-cardiac-malformations
#18
JOURNAL ARTICLE
Y L Yang, Z Y Feng, C Wang, X Z Lyu, H H Xu, W M Wang, Y C Pang
Objective: To examine the treatment strategy of congenital tracheal stenosis associated with non-vascular ring cardiac malformations. Methods: This is a retrospective case series. Clinic data from 24 children with tracheal stenosis who underwent surgical treatment in the Department of Cardiac Surgery, Children's Hospital Affiliated to Shandong University from February 2017 to March 2023 were retrospectively collected. There were 16 males and 8 females, aged ( M (IQR)) 6.5 (19.6) months (range: 2.2 to 66.3 months) and weighted 5...
December 1, 2023: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://read.qxmd.com/read/38024550/designing-a-multiplex-pcr-for-rapid-and-accurate-detection-of-metallobetalactamases-resistant-genes-from-acinetobacter-baumanii-isolates-in-tehran-city-iran
#19
JOURNAL ARTICLE
Zahra Mottaghiyan, Davoud Esmaeili, Mohammad Hossein Ahmadi, Mohammad Niakan
BACKGROUND & OBJECTIVE: Acinetobacter baumannii strains harboring Meallobetalactamases (MBL) pose a significant threat in the context of nosocomial infections. The present investigation was undertaken with the objective of devising a Multiplex PCR methodology for the concurrent detection of MBL genes within A. baumannii strains prevalent in Tehran City, Iran. METHODS: Between October 2020 and February 2021, 100 strains of A. baumannii were procured from burn specimens of hospitalized patients at Motahhari Hospital in Tehran...
2023: Iranian Journal of Pathology
https://read.qxmd.com/read/38022156/prediction-of-antigenic-vaccine-peptide-candidates-from-bfmrs-associated-with-biofilm-formation-in-acinetobacter-baumannii
#20
JOURNAL ARTICLE
A S Smiline Girija
INTRODUCTION:   A. baumannii is categorized as a priority pathogen due to its propensity for multi-drug resistance, exhibiting resistance against the last resort of antibiotics. It is also considered a potent nosocomial pathogen, so targeting the microbe using novel strategies would be the need of the hour. In this context, the in-silico computational approach would serve the best to design the possible epitope peptides, which may be further considered for the experimental trials for their immunological response...
October 2023: Curēus
keyword
keyword
41306
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.