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acinetobacter baumanii

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https://www.readbyqxmd.com/read/29743760/antibiotic-prescription-organisms-and-its-resistance-pattern-in-patients-admitted-to-respiratory-icu-with-respiratory-infection-in-mysuru
#1
M Mahendra, B S Jayaraj, K S Lokesh, S K Chaya, Vivek Vardhan Veerapaneni, Sneha Limaye, Raja Dhar, Rajesh Swarnakar, Shrikant Ambalkar, P A Mahesh
Aim of Study: Respiratory infections account for significant morbidity, mortality and expenses to patients getting admitted to ICU. Antibiotic resistance is a major worldwide concern in ICU, including India. It is important to know the antibiotic prescribing pattern in ICU, organisms and its resistance pattern as there is sparse data on Indian ICUs. Materials and Methods: We conducted a prospective study from August 2015 to February 2016. All patients getting admitted to RICU with respiratory infection who were treated with antibiotics were included into study...
April 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29738654/-multidrug-resistance-e-eskape-strains-isolated-from-blood-cultures-in-patients-with-cancer
#2
Consuelo Velázquez-Acosta, Patricia Cornejo-Juárez, Patricia Volkow-Fernández
OBJECTIVE: To describe the trend of multidrug resistant (MDR) strains isolated from blood in patients with cancer from 2005 to 2015. MATERIAL AND METHODS: 33 127 blood cultures were processed by retrospective analysis. Identification and antimicrobial sensitivity were performed through automated methods: WaLK away (Siemens Labora- tory Diagnostics) and BD Phoenix (Becton, Dickinson and Company). Resistant strains were determined according to the minimum inhibitory concentration, following the parameters of the Clinical and Laboratory Standards Institute (CLSI)...
March 2018: Salud Pública de México
https://www.readbyqxmd.com/read/29690742/-application-of-recombinase-polymerase-amplification-in-the-detection-of-pseudomonas-aeruginosa
#3
X J Jin, Y L Gong, L Yang, B H Mo, Y Z Peng, P He, J N Zhao, X L Li
Objective: To establish an optimized method of recombinase polymerase amplification (RPA) to rapidly detect Pseudomonas aeruginosa in clinic. Methods: (1) The DNA templates of one standard Pseudomonas aeruginosa strain was extracted and detected by polymerase chain reaction (PCR), real-time fluorescence quantitative PCR and RPA. Time of sample loading, time of amplification, and time of detection of the three methods were recorded. (2) One standard Pseudomonas aeruginosa strain was diluted in 7 concentrations of 1×10(7,) 1×10(6,) 1×10(5,) 1×10(4,) 1×10(3,) 1×10(2,) and 1×10(1) colony forming unit (CFU)/mL after recovery and cultivation...
April 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29662260/characterization-of-multidrug-resistant-acinetobacter-ssp-strains-isolated-from-medical-intensive-care-units-in-cali-colombia
#4
Rómel Fabian Gómez, Andres Castillo, Mónica Chávez-Vivas
Introduction: The extensive use of antibiotics has led to the emergence of multi-resistant strains in some species of the genus Acinetobacter . Objective: To investigate the molecular characteristics of multidrug-resistant of Acinetobacter ssp. strains isolated from 52 patients collected between March 2009 and July 2010 in medical intensive care units in Cali - Colombia. Methods: The susceptibility to various classes of antibiotics was determined by disc diffusion method, and the determination of the genomic species was carried out using amplified ribosomal DNA restriction analysis (ARDRA) and by sequencing of the 16s rDNA gene...
December 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29643650/minocycline-the-second-important-antimicrobial-in-multidrug-resistant-acinetobacter-baumanii-infections
#5
Abhijit S Nair
No abstract text is available yet for this article.
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29642501/isolation-of-bioactive-compounds-from-calicotome-villosa-stems
#6
Josiane Alhage, Hoda Elbitar, Samir Taha, Jean-Paul Guegan, Zeina Dassouki, Thomas Vives, Thierry Benvegnu
A phenylethanoid, two steroids, a flavone glucoside and a chalcone have been isolated for the first time from the stems of Calicotome villosa together with a previously isolated flavone glucoside. Their structures were determined by spectroscopic analyses (NMR, HRMS) as basalethanoïd B ( 1 ), β-sitosterol and stigmasterol ( 2 ), chrysine-7- O -β-d-glucopyranoside ( 3 ), chrysine 7-((6''- O -acetyl)- O -β-d-glucopyranoside) ( 4 ) and calythropsin ( 5 ). The crude extracts and the isolated compounds (except 4), were evaluated for their antioxidant, antimicrobial (against two Gram-positive bacterial strains: Staphylococcus aureus , Bacillus cereus , four Gram-negative bacterial strains: Staphylococcus epidermidis , Klebsiella pneumonia , Acinetobacter baumanii , and three yeasts: Candida albicans , Candida tropicalis , and Candida glabrata ), hemolytic, antidiabetic, anti-inflammatory and cytotoxic activity...
April 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29589993/incidence-of-multidrug-resistant-organism-among-children-admitted-to-pediatric-intensive-care-unit-in-a-developing-country
#7
Ahmed El-Nawawy, Galal A Ashraf, Manal A M Antonios, Marwa A Meheissen, Marwa M R El-Alfy
AIM: Multidrug-resistant infections are an increasingly common condition particularly in critical care units. This study aimed to determine the incidence and types of resistant bacteria acquired in a pediatric intensive care unit (PICU) of a university hospital. SUBJECT AND METHODS: A prospective study was conducted during the year 2016. All children aged below 16 years were studied for infection development and pattern of susceptibility to various groups of antibiotics...
March 28, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29582720/multidrug-resistant-acinetobacter-baumanii-a-15-year-trend-analysis
#8
Dana L Russell, Daniel Z Uslan, Zachary A Rubin, Tristan R Grogan, Elise M Martin
From 2000 to 2009, rates of multidrug-resistant Acinetobacter baumanii increased 10-fold to 0.2 per 1,000 patient days. From 2010 to 2015, however, rates markedly declined and have stayed below 0.05 per 1,000 patient days. Herein, we present a 15-year trend analysis and discuss interventions that may have led to the decline.Infect Control Hosp Epidemiol 2018;1-4.
March 27, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29461939/antibacterial-properties-of-four-novel-hit-compounds-from-a-methicillin-resistant-staphylococcus-aureus-caenorhabditis-elegans-high-throughput-screen
#9
Nagendran Tharmalingam, Rajmohan Rajmuthiah, Wooseong Kim, Beth Burgwyn Fuchs, Elamparithi Jeyamani, Michael J Kelso, Eleftherios Mylonakis
There is an urgent need for the discovery of effective new antimicrobial agents to combat the rise of bacterial drug resistance. High-throughput screening (HTS) in whole-animal infection models is a powerful tool for identifying compounds that show antibacterial activity and low host toxicity. In this report, we characterize the activities of four novel antistaphylococcal compounds identified from an HTS campaign conducted using Caenorhabditis elegans nematodes infected with methicillin-resistant Staphylococcus aureus (MRSA)...
February 20, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29396362/discovery-of-2-aminothiazolyl-berberine-derivatives-as-effectively-antibacterial-agents-toward-clinically-drug-resistant-gram-negative-acinetobacter-baumanii
#10
Wei-Wei Gao, Lavanya Gopala, Rammohan R Yadav Bheemanaboina, Guo-Biao Zhang, Shuo Li, Cheng-He Zhou
Aminothiazolyl berberine derivatives as potentially antimicrobial agents were designed and synthesized in an effort to overcome drug resistance. The antimicrobial assay revealed that some target compounds exhibited significantly inhibitory efficiencies toward bacteria and fungi including drug-resistant pathogens, and the aminothiazole and Schiff base moieties were helpful structural fragments for aqueous solubility and antibacterial activity. Especially, aminothiazolyl 9-hexyl berberine 9c and 2,4-dichlorobenzyl derivative 18a exhibited good activities (MIC = 2 nmol/mL) against clinically drug-resistant Gram-negative Acinetobacter baumanii with low cytotoxicity to hepatocyte LO2 cells, rapidly bactericidal effects and quite slow development of bacterial resistance toward A...
February 25, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29366864/green-synthesized-silver-nanoparticles-by-marine-endophytic-fungus-penicillium-polonicum-and-its-antibacterial-efficacy-against-biofilm-forming-multidrug-resistant-acinetobacter-baumanii
#11
Sahadevan Neethu, Sebastian Jose Midhun, E K Radhakrishnan, Mathew Jyothis
Acinetobacter baumanii, a gram-negative, non-motile, encapsulated coccobacillus which causes infections worldwide. The objective of this study was to find a fungal strain that could be utilized to biosynthesize antibacterial silver nanoparticles (AgNPs) against Acinetobacter baumanii. The present investigation explains rapid and extracellular biosynthesis of silver nanoparticles by the algicolous endophytic fungus, Penicillium polonicum, isolated from the marine green alga Chetomorpha antennina. The obtained silver nanoparticles were characterized by UV-Vis spectroscopy, Raman spectroscopy, Fourier transformation infrared (FTIR), and Transmission electron microscopy (TEM)...
March 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29226091/successful-treatment-of-multicompartmental-cerebral-ventriculitis-caused-by-acinetobacter-baumanii
#12
Mahableshwar Albur
We present a case report of a 58-year- old woman with subarachnoid haemorrhage complicated by non-communicating hydrocephalus. During the course of her neurosurgical management, she developed external-ventricular drain associated ventriculitis which in turn was complicated by lack of communication between third and fourth ventricles. The causative organism was a fully-sensitive Acinetobacter baumanii , a nosocomial pathogen often associated with complicated treatment regimens and poor outcomes. This patient was successfully managed by a multi-disciplinary team involving neurosurgeons, neuroradiologists and infection specialists...
2018: IDCases
https://www.readbyqxmd.com/read/29224317/-a-multicenter-retrospective-study-of-pathogenic-bacteria-distribution-and-drug-resistance-in-febrile-neutropenic-patients-with-hematological-diseases-in-shanghai
#13
J Zhu, J Hu, Y F Mao, F Y Chen, J Y Zhu, J M Shi, D D Yu, S G Hao, R Tao, P Liu, S Y Gu, J Hou, H Y He, A B Liang, Y Ding, L G Liu, Y H Xie, Q Zhu, Y H Yu, Y H Yao, W Chen, H L Xu, X H Han, C Wang
Objective: To investigate the pathogen spectrum distribution and drug resistance of febrile neutropenic patients with hematological diseases in Shanghai. Methods: A retrospective study was conducted on the clinical isolates from the febrile neutropenic patients hospitalized in the departments of hematology in 12 general hospitals in Shanghai from January 2012 to December 2014. The drug susceptibility test was carried out by Kirby-Bauer method. WHONET 5.6 software was used to analyze pathogenic bacteria and drug susceptibility data...
November 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29207958/bloodstream-infections-at-a-tertiary-level-paediatric-hospital-in-south-africa
#14
Harsha Lochan, Vashini Pillay, Colleen Bamford, James Nuttall, Brian Eley
BACKGROUND: Bloodstream infection (BSI) in children causes significant morbidity and mortality. There are few studies describing the epidemiology of BSI in South African children. METHODS: A retrospective descriptive cohort study was conducted at a paediatric referral hospital in Cape Town, South Africa. The National Health Laboratory Service (NHLS) microbiology database was accessed to identify positive blood culture specimens during the period 2011-2012. Demographic and clinical details, antimicrobial management and patient outcome information were extracted from medical and laboratory records...
December 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29075483/extended-spectrum-and-metalo-beta-lactamase-producing-airborne-pseudomonas-aeruginosa-and-acinetobacter-baumanii-in-restricted-settings-of-a-referral-hospital-a-neglected-condition
#15
Fithamlak Bisetegen Solomon, Fiseha Wadilo, Efrata Girma Tufa, Meseret Mitiku
BACKGROUND: Frequently encountered multidrug-resistant bacterial isolates of P. aeruginosa and A. baumannii are common and prevalent in a hospital environment. The aim of this study was to determine the prevalence and pattern of antibiotic resistance, extended spectrum and metallo beta-lactamase producing P. aeruginosa and A. baumannii isolates from restricted settings of indoor air hospital environment. METHODS: A hospital-based cross-sectional study was conducted in Wolaita Sodo University Teaching and referral Hospital, Ethiopia from December 1/2015 to April 30/2015...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29063446/extensive-colonization-with-carbapenemase-producing-microorganisms-in-romanian-burn-patients-infectious-consequences-from-the-colectiv-fire-disaster
#16
L E Pirii, A W Friedrich, J W A Rossen, W Vogels, G I J M Beerthuizen, M K Nieuwenhuis, A M D Kooistra-Smid, E Bathoorn
Health care of severe burn patients is highly specialized and may require international patient transfer. Burn patients have an increased risk of developing infections. Patients that have been hospitalized in countries where carbapenemase-producing microorganisms (CPMO) are endemic may develop infections that are difficult to treat. In addition, there is a risk on outbreaks with CPMOs in burn centers. This study underlines that burn patients may extensively be colonized with CPMOs, and it provides best practice recommendations regarding clinical microbiology and infection control...
January 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29062249/a-retrospective-evaluation-of-blood-cultures-in-a-pediatric-intensive-care-unit-a-three-year-evaluation
#17
Ayşe Betül Ergül, Halit Işık, Yasemin Ay Altıntop, Yasemin Altuner Torun
AIM: In this study, it was aimed to retrospectively assess the frequency and antibiotic resistance of microorganisms isolated from blood cultures of patients in a pediatric intensive care unit. MATERIAL AND METHODS: The study was conducted on blood culture tests obtained from patients in a pediatric intensive care unit and sent to a microbiology laboratory between 2013 and 2016. The species and antibiotic susceptibilities were assessed in microorganisms isolated from the blood cultures...
September 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/29026836/anti-n-methyl-d-aspartate-receptor-encephalitis-that-aggravates-after-acinetobacter-baumannii-pneumonia-a-case-report
#18
Cheng C Wang, Da J Li, Yi Q Xia, Kai Liu
We report an atypical case of anti-N-methyl-D-aspartate receptor encephalitis (ANMDARE). A 27-year-old man diagnosed with ANMDARE received immunotherapy and had a good recovery. However, within one month, he developed severe status epilepticus and decreased level of conscience with new hyperpyrexia and dyspnea, and was admitted to the emergency intensive care unit. Acinetobacter baumanii were found in the sputum culture; and anti-NMDAR antibodies were positive (titer: 1/80) in the cerebrospinal fluid. Repeated immunotherapy was administered with antibacterial agents, and the patient recovered except for mild psychiatric sequelae...
September 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28936955/-analysis-of-characteristics-of-bacteria-in-respiratory-tract-infection-in-2013-2016-in-heibei-3a-hospital-a-single-center-report-of-7-497-patients
#19
Lili Hou, Lili Liu, Ping Dang, Guannan Kang, Qinfeng Zhang, Dongling Li
OBJECTIVE: To analyze the changes and characteristics of respiratory tract bacteria in Hebei 3A Hospital, and to provide new rationale for clinical diagnosis and treatment. METHODS: A single-center retrospective analysis was conducted. 7 497 patients with respiratory tract infection admitted to Hebei Chest Hospital from January 2013 to December 2016 were enrolled. Deep sputum was collected, and the bacterial cultures and susceptibility analysis was conducted in sputum and upper respiratory secretions were collected by fiberoptic bronchoscopy...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28877761/phenotypic-prevalence-of-extended-spectrum-beta-lactamases-among-enterobacteriaceae-isolated-at-mulago-national-referral-hospital-uganda
#20
Lucas Ampaire, Emmanuel Nduhura, Izale Wewedru
OBJECTIVE: Enterobacteriaceae, common causes of health care associated and community acquired infections are mainly treated with beta-lactam agents. Our study objective was to determine the prevalence and common enterobacteriaceae pathogen producing extended spectrum beta lactamases (ESBLs). The isolates were recovered from various clinical specimens. This was cross sectional study conducted between July 2016 and September 2016 at Mulago National Referral Hospital, Uganda. We used ChromID™ ESBL agar (Biomerieux SA, Lyon, France) and Vitek2 compact system GN83 card (BioMerieux Inc, Hazelwood, Missouri, USA) to detect and confirm presence of phenotypic extended spectrum beta lactamases producing pathogens respectively...
September 6, 2017: BMC Research Notes
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