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Rebecca gerlach

Rebecca M Gerlach, Mark A Chaney
No abstract text is available yet for this article.
March 2018: Journal of Thoracic and Cardiovascular Surgery
Nicolas Andre Stewart, Raquel Fernanda Gerlach, Rebecca L Gowland, Kurt J Gron, Janet Montgomery
The assignment of biological sex to archaeological human skeletons is a fundamental requirement for the reconstruction of the human past. It is conventionally and routinely performed on adults using metric analysis and morphological traits arising from postpubertal sexual dimorphism. A maximum accuracy of ∼95% is possible if both the cranium and os coxae are present and intact, but this is seldom achievable for all skeletons. Furthermore, for infants and juveniles, there are no reliable morphological methods for sex determination without resorting to DNA analysis, which requires good DNA survival and is time-consuming...
December 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
Rebecca Gerlach, Avery Tung
No abstract text is available yet for this article.
November 2017: Anesthesiology
Paul T Kroeger, Bridgette E Drummond, Rachel Miceli, Michael McKernan, Gary F Gerlach, Amanda N Marra, Annemarie Fox, Kristen K McCampbell, Ignaty Leshchiner, Adriana Rodriguez-Mari, Ruth BreMiller, Ryan Thummel, Alan J Davidson, John Postlethwait, Wolfram Goessling, Rebecca A Wingert
The zebrafish kidney is conserved with other vertebrates, making it an excellent genetic model to study renal development. The kidney collects metabolic waste using a blood filter with specialized epithelial cells known as podocytes. Podocyte formation is poorly understood but relevant to many kidney diseases, as podocyte injury leads to progressive scarring and organ failure. zeppelin (zep) was isolated in a forward screen for kidney mutants and identified as a homozygous recessive lethal allele that causes reduced podocyte numbers, deficient filtration, and fluid imbalance...
August 1, 2017: Developmental Biology
Alison J Gerlach, Gail Teachman, Debbie Laliberte-Rudman, Rebecca M Aldrich, Suzanne Huot
BACKGROUND: Perspectives that individualize occupation are poorly aligned with socially responsive and transformative occupation-focused research, education, and practice. Their predominant use in occupational therapy risks the perpetuation, rather than resolution, of occupational inequities. AIM: In this paper, we problematize taken-for-granted individualistic analyses of occupation and illustrate how critical theoretical perspectives can reveal the ways in which structural factors beyond an individual's immediate control and environment shape occupational possibilities and occupational engagement...
January 2018: Scandinavian Journal of Occupational Therapy
Harish Ram, Rebecca M Gerlach, Antonio Hernandez Conte, Danny Ramzy, Ashley R Jaramillo-Huff, Neal S Gerstein
No abstract text is available yet for this article.
June 2017: Journal of Cardiothoracic and Vascular Anesthesia
Andrew Hollatz, Husam H Balkhy, Mark A Chaney, Peter J Neuburger, Rebecca M Gerlach, T Sloane Guy
No abstract text is available yet for this article.
February 2017: Journal of Cardiothoracic and Vascular Anesthesia
Rebecca Bentzen, J Margaret Castellini, Robert Gerlach, Claude Dykstra, Todd O'Hara
Total mercury concentrations ([THg]), δ(15)N and δ(13)C values were determined in muscle of 693 Pacific halibut caught in International Pacific Halibut Commission setline surveys in Alaska (2002-2011). Project goals were to evaluate whether 1) δ(15)N and δ(13)C varied with region, age, sex and length of halibut, and 2) muscle [THg] varied with δ(15)N and δ(13)C (feeding ecology) while accounting for sex, length, and region. Variation in [THg] was explained, in part, by halibut feeding ecology as [THg] increased with trophic position (increasing δ(15)N)...
December 15, 2016: Marine Pollution Bulletin
Rebecca M Gerlach, Danny Ramzy, Lorraine Lubin, Antonio Hernandez Conte
No abstract text is available yet for this article.
March 2016: Anesthesia and Analgesia
Michael Essandoh, Andrew J Otey, Juan Crestanello, Jonathan Keshishian, Patrick G Brady, Rebecca M Gerlach
No abstract text is available yet for this article.
October 2015: Journal of Cardiothoracic and Vascular Anesthesia
Gary F Gerlach, Elvin E Morales, Rebecca A Wingert
The zebrafish has emerged as a valuable genetic model system for the study of developmental biology and disease. Zebrafish share a high degree of genomic conservation, as well as similarities in cellular, molecular, and physiological processes, with other vertebrates including humans. During early ontogeny, zebrafish embryos are optically transparent, allowing researchers to visualize the dynamics of organogenesis using a simple stereomicroscope. Microbead implantation is a method that enables tissue manipulation through the alteration of factors in local environments...
2015: Journal of Visualized Experiments: JoVE
Rebecca M Gerlach, Adam B Barrus, Danny Ramzy, Antonio Hernandez Conte, Swapnil Khoche, Sharon L McCartney, Madhav Swaminathan
No abstract text is available yet for this article.
August 2015: Journal of Cardiothoracic and Vascular Anesthesia
Claire Elizabeth Payne, Adam R Brown, Jonathon W Theile, Alexandre J C Loucif, Aristos J Alexandrou, Mathew D Fuller, John H Mahoney, Brett M Antonio, Aaron C Gerlach, David M Printzenhoff, Rebecca L Prime, Gillian Stockbridge, Anthony J Kirkup, Anthony W Bannon, Steve England, Mark L Chapman, Sharan Bagal, Rosemarie Roeloffs, Uma Anand, Praveen Anand, Peter J Bungay, Mark Kemp, Richard P Butt, Edward B Stevens
BACKGROUND AND PURPOSE: NaV 1.8 ion channels have been highlighted as important molecular targets for the design of low MW blockers for the treatment of chronic pain. Here, we describe the effects of PF-01247324, a new generation, selective, orally bioavailable Nav 1.8 channel blocker of novel chemotype. EXPERIMENTAL APPROACH: The inhibition of Nav 1.8 channels by PF-01247324 was studied using in vitro patch-clamp electrophysiology and the oral bioavailability and antinociceptive effects demonstrated using in vivo rodent models of inflammatory and neuropathic pain...
May 2015: British Journal of Pharmacology
Rebecca Gerlach, David Mark, Anujan Poologaindran, Rob Tanzola
No abstract text is available yet for this article.
February 2015: Anesthesia and Analgesia
Robert McKee, Gary F Gerlach, Jonathan Jou, Christina N Cheng, Rebecca A Wingert
The kidney is comprised of nephrons - epithelial tubes with specialized segments that reabsorb and secrete solutes, perform osmoregulation, and produce urine. Different nephron segments exhibit unique combinations of ion channels, transporter proteins, and cell junction proteins that govern permeability between neighboring cells. The zebrafish pronephros is a valuable model to study the mechanisms of vertebrate nephrogenesis, but many basic features of segment gene expression in renal progenitors and mature nephrons have not been characterized...
November 2014: Gene Expression Patterns: GEP
Gary F Gerlach, Rebecca A Wingert
The zebrafish pronephros provides an excellent in vivo system to study the mechanisms of vertebrate nephron development. When and how renal progenitors in the zebrafish embryo undergo tubulogenesis to form nephrons is poorly understood, but is known to involve a mesenchymal to epithelial transition (MET) and the acquisition of polarity. Here, we determined the precise timing of these events in pronephros tubulogenesis. As the ternary polarity complex is an essential regulator of epithelial cell polarity across tissues, we performed gene knockdown studies to assess the roles of the related factors atypical protein kinase C iota and zeta (prkcι, prkcζ)...
December 15, 2014: Developmental Biology
Paul T Kroeger, Douglas A Shoue, Frank M Mezzacappa, Gary F Gerlach, Rebecca A Wingert, Robert A Schulz
In Drosophila, circulating hemocytes are derived from the cephalic mesoderm during the embryonic wave of hematopoiesis. These cells are contributed to the larva and persist through metamorphosis into the adult. To analyze this population of hemocytes, we considered data from a previously published RNAi screen in the hematopoietic niche, which suggested several members of the SCF complex play a role in lymph gland development. eater-Gal4;UAS-GFP flies were crossed to UAS-RNAi lines to knockdown the function of all known SCF complex members in a plasmatocyte-specific fashion, in order to identify which members are novel regulators of plasmatocytes...
2013: PloS One
Gary F Gerlach, Rebecca A Wingert
Vertebrates form a progressive series of up to three kidney organs during development-the pronephros, mesonephros, and metanephros. Each kidney derives from the intermediate mesoderm and is comprised of conserved excretory units called nephrons. The zebrafish is a powerful model for vertebrate developmental genetics, and recent studies have illustrated that zebrafish and mammals share numerous similarities in nephron composition and physiology. The zebrafish embryo forms an architecturally simple pronephros that has two nephrons, and these eventually become a scaffold onto which a mesonephros of several hundred nephrons is constructed during larval stages...
September 2013: Wiley Interdisciplinary Reviews. Developmental Biology
Rebecca M Gerlach, Rob Tanzola, Rene Allard
No abstract text is available yet for this article.
July 2013: Anesthesia and Analgesia
Rebecca M Gerlach, Tarit K Saha, Rene V Allard, Rob C Tanzola
PURPOSE: We report a case of unrecognized cardiac tamponade diagnosed pre-induction by focused transthoracic echocardiography (TTE). The value of focused perioperative TTE, the anesthetic implications of Churg-Strauss syndrome, and the diagnosis of cardiac tamponade are discussed. CLINICAL FEATURES: A 58-yr-old man with a history of severe asymptomatic aortic stenosis presented for elective endoscopic sinus surgery for intractable nasal polyps with recurrent sinusitis...
August 2013: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
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