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Rebecca gerlach

Rebecca Bentzen, J Margaret Castellini, Robert Gerlach, Claude Dykstra, Todd O'Hara
Total mercury concentrations ([THg]), δ(15)N and δ(13)C values were determined in muscle of 693 Pacific halibut caught in International Pacific Halibut Commission setline surveys in Alaska (2002-2011). Project goals were to evaluate whether 1) δ(15)N and δ(13)C varied with region, age, sex and length of halibut, and 2) muscle [THg] varied with δ(15)N and δ(13)C (feeding ecology) while accounting for sex, length, and region. Variation in [THg] was explained, in part, by halibut feeding ecology as [THg] increased with trophic position (increasing δ(15)N)...
December 15, 2016: Marine Pollution Bulletin
Rebecca M Gerlach, Danny Ramzy, Lorraine Lubin, Antonio Hernandez Conte
No abstract text is available yet for this article.
March 2016: Anesthesia and Analgesia
Michael Essandoh, Andrew J Otey, Juan Crestanello, Jonathan Keshishian, Patrick G Brady, Rebecca M Gerlach
No abstract text is available yet for this article.
October 2015: Journal of Cardiothoracic and Vascular Anesthesia
Gary F Gerlach, Elvin E Morales, Rebecca A Wingert
The zebrafish has emerged as a valuable genetic model system for the study of developmental biology and disease. Zebrafish share a high degree of genomic conservation, as well as similarities in cellular, molecular, and physiological processes, with other vertebrates including humans. During early ontogeny, zebrafish embryos are optically transparent, allowing researchers to visualize the dynamics of organogenesis using a simple stereomicroscope. Microbead implantation is a method that enables tissue manipulation through the alteration of factors in local environments...
2015: Journal of Visualized Experiments: JoVE
Rebecca M Gerlach, Adam B Barrus, Danny Ramzy, Antonio Hernandez Conte, Swapnil Khoche, Sharon L McCartney, Madhav Swaminathan
No abstract text is available yet for this article.
August 2015: Journal of Cardiothoracic and Vascular Anesthesia
Claire Elizabeth Payne, Adam R Brown, Jonathon W Theile, Alexandre J C Loucif, Aristos J Alexandrou, Mathew D Fuller, John H Mahoney, Brett M Antonio, Aaron C Gerlach, David M Printzenhoff, Rebecca L Prime, Gillian Stockbridge, Anthony J Kirkup, Anthony W Bannon, Steve England, Mark L Chapman, Sharan Bagal, Rosemarie Roeloffs, Uma Anand, Praveen Anand, Peter J Bungay, Mark Kemp, Richard P Butt, Edward B Stevens
BACKGROUND AND PURPOSE: NaV 1.8 ion channels have been highlighted as important molecular targets for the design of low MW blockers for the treatment of chronic pain. Here, we describe the effects of PF-01247324, a new generation, selective, orally bioavailable Nav 1.8 channel blocker of novel chemotype. EXPERIMENTAL APPROACH: The inhibition of Nav 1.8 channels by PF-01247324 was studied using in vitro patch-clamp electrophysiology and the oral bioavailability and antinociceptive effects demonstrated using in vivo rodent models of inflammatory and neuropathic pain...
May 2015: British Journal of Pharmacology
Rebecca Gerlach, David Mark, Anujan Poologaindran, Rob Tanzola
No abstract text is available yet for this article.
February 2015: Anesthesia and Analgesia
Robert McKee, Gary F Gerlach, Jonathan Jou, Christina N Cheng, Rebecca A Wingert
The kidney is comprised of nephrons - epithelial tubes with specialized segments that reabsorb and secrete solutes, perform osmoregulation, and produce urine. Different nephron segments exhibit unique combinations of ion channels, transporter proteins, and cell junction proteins that govern permeability between neighboring cells. The zebrafish pronephros is a valuable model to study the mechanisms of vertebrate nephrogenesis, but many basic features of segment gene expression in renal progenitors and mature nephrons have not been characterized...
November 2014: Gene Expression Patterns: GEP
Gary F Gerlach, Rebecca A Wingert
The zebrafish pronephros provides an excellent in vivo system to study the mechanisms of vertebrate nephron development. When and how renal progenitors in the zebrafish embryo undergo tubulogenesis to form nephrons is poorly understood, but is known to involve a mesenchymal to epithelial transition (MET) and the acquisition of polarity. Here, we determined the precise timing of these events in pronephros tubulogenesis. As the ternary polarity complex is an essential regulator of epithelial cell polarity across tissues, we performed gene knockdown studies to assess the roles of the related factors atypical protein kinase C iota and zeta (prkcι, prkcζ)...
December 15, 2014: Developmental Biology
Paul T Kroeger, Douglas A Shoue, Frank M Mezzacappa, Gary F Gerlach, Rebecca A Wingert, Robert A Schulz
In Drosophila, circulating hemocytes are derived from the cephalic mesoderm during the embryonic wave of hematopoiesis. These cells are contributed to the larva and persist through metamorphosis into the adult. To analyze this population of hemocytes, we considered data from a previously published RNAi screen in the hematopoietic niche, which suggested several members of the SCF complex play a role in lymph gland development. eater-Gal4;UAS-GFP flies were crossed to UAS-RNAi lines to knockdown the function of all known SCF complex members in a plasmatocyte-specific fashion, in order to identify which members are novel regulators of plasmatocytes...
2013: PloS One
Gary F Gerlach, Rebecca A Wingert
Vertebrates form a progressive series of up to three kidney organs during development-the pronephros, mesonephros, and metanephros. Each kidney derives from the intermediate mesoderm and is comprised of conserved excretory units called nephrons. The zebrafish is a powerful model for vertebrate developmental genetics, and recent studies have illustrated that zebrafish and mammals share numerous similarities in nephron composition and physiology. The zebrafish embryo forms an architecturally simple pronephros that has two nephrons, and these eventually become a scaffold onto which a mesonephros of several hundred nephrons is constructed during larval stages...
September 2013: Wiley Interdisciplinary Reviews. Developmental Biology
Rebecca M Gerlach, Rob Tanzola, Rene Allard
No abstract text is available yet for this article.
July 2013: Anesthesia and Analgesia
Rebecca M Gerlach, Tarit K Saha, Rene V Allard, Rob C Tanzola
PURPOSE: We report a case of unrecognized cardiac tamponade diagnosed pre-induction by focused transthoracic echocardiography (TTE). The value of focused perioperative TTE, the anesthetic implications of Churg-Strauss syndrome, and the diagnosis of cardiac tamponade are discussed. CLINICAL FEATURES: A 58-yr-old man with a history of severe asymptomatic aortic stenosis presented for elective endoscopic sinus surgery for intractable nasal polyps with recurrent sinusitis...
August 2013: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
Franziska Leonhardt, Sebastian Grundmann, Martin Behe, Franziska Bluhm, Rebecca A Dumont, Friederike Braun, Melpomeni Fani, Katarina Riesner, Gabriele Prinz, Anne-Kathrin Hechinger, Ulrike V Gerlach, Heide Dierbach, Olaf Penack, Annette Schmitt-Gräff, Jürgen Finke, Wolfgang A Weber, Robert Zeiser
Acute graft-versus-host disease (GvHD) is a complex process involving endothelial damage and neovascularization. Better understanding of the pathophysiology of neovascularization during GvHD could help to target this process while leaving T-cell function intact. Under ischemic conditions, neovascularization is regulated by different micro RNAs (miRs), which potentially play a role in inflamed hypoxic GvHD target organs. We observed strong neovascularization in the murine inflamed intestinal tract (IT) during GvHD...
April 25, 2013: Blood
Gary F Gerlach, Lauran N Schrader, Rebecca A Wingert
Researchers working in the burgeoning field of adult stem cell biology seek to understand the signals that regulate the behavior and function of stem cells during normal homeostasis and disease states. The understanding of adult stem cells has broad reaching implications for the future of regenerative medicine. For example, better knowledge about adult stem cell biology can facilitate the design of therapeutic strategies in which organs are triggered to heal themselves or even the creation of methods for growing organs in vitro that can be transplanted into humans...
2011: Journal of Visualized Experiments: JoVE
Claire V Murphy, Rebecca Coffey, Charles H Cook, Anthony T Gerlach, Sidney F Miller
Glucose management in patients with burn injury is often difficult because of their hypermetabolic state with associated hyperglycemia, hyperinsulinemia, and insulin resistance. Recent studies suggest that time to glycemic control is associated with improved outcomes. The authors sought to determine the influence of early glycemic control on the outcomes of critically ill patients with burn injury. A retrospective analysis was performed at the Ohio State University Medical Center. Patients hospitalized with burn injury were enrolled if they were admitted to the intensive care unit between March 1, 2006, and February 28, 2009...
November 2011: Journal of Burn Care & Research: Official Publication of the American Burn Association
Michael Hoffmann, Craig Hilton-Taylor, Ariadne Angulo, Monika Böhm, Thomas M Brooks, Stuart H M Butchart, Kent E Carpenter, Janice Chanson, Ben Collen, Neil A Cox, William R T Darwall, Nicholas K Dulvy, Lucy R Harrison, Vineet Katariya, Caroline M Pollock, Suhel Quader, Nadia I Richman, Ana S L Rodrigues, Marcelo F Tognelli, Jean-Christophe Vié, John M Aguiar, David J Allen, Gerald R Allen, Giovanni Amori, Natalia B Ananjeva, Franco Andreone, Paul Andrew, Aida Luz Aquino Ortiz, Jonathan E M Baillie, Ricardo Baldi, Ben D Bell, S D Biju, Jeremy P Bird, Patricia Black-Decima, J Julian Blanc, Federico Bolaños, Wilmar Bolivar-G, Ian J Burfield, James A Burton, David R Capper, Fernando Castro, Gianluca Catullo, Rachel D Cavanagh, Alan Channing, Ning Labbish Chao, Anna M Chenery, Federica Chiozza, Viola Clausnitzer, Nigel J Collar, Leah C Collett, Bruce B Collette, Claudia F Cortez Fernandez, Matthew T Craig, Michael J Crosby, Neil Cumberlidge, Annabelle Cuttelod, Andrew E Derocher, Arvin C Diesmos, John S Donaldson, J W Duckworth, Guy Dutson, S K Dutta, Richard H Emslie, Aljos Farjon, Sarah Fowler, Jörg Freyhof, David L Garshelis, Justin Gerlach, David J Gower, Tandora D Grant, Geoffrey A Hammerson, Richard B Harris, Lawrence R Heaney, S Blair Hedges, Jean-Marc Hero, Baz Hughes, Syed Ainul Hussain, Javier Icochea M, Robert F Inger, Nobuo Ishii, Djoko T Iskandar, Richard K B Jenkins, Yoshio Kaneko, Maurice Kottelat, Kit M Kovacs, Sergius L Kuzmin, Enrique La Marca, John F Lamoreux, Michael W N Lau, Esteban O Lavilla, Kristin Leus, Rebecca L Lewison, Gabriela Lichtenstein, Suzanne R Livingstone, Vimoksalehi Lukoschek, David P Mallon, Philip J K McGowan, Anna McIvor, Patricia D Moehlman, Sanjay Molur, Antonio Muñoz Alonso, John A Musick, Kristin Nowell, Ronald A Nussbaum, Wanda Olech, Nikolay L Orlov, Theodore J Papenfuss, Gabriela Parra-Olea, William F Perrin, Beth A Polidoro, Mohammad Pourkazemi, Paul A Racey, James S Ragle, Mala Ram, Galen Rathbun, Robert P Reynolds, Anders G J Rhodin, Stephen J Richards, Lily O Rodríguez, Santiago R Ron, Carlo Rondinini, Anthony B Rylands, Yvonne Sadovy de Mitcheson, Jonnell C Sanciangco, Kate L Sanders, Georgina Santos-Barrera, Jan Schipper, Caryn Self-Sullivan, Yichuan Shi, Alan Shoemaker, Frederick T Short, Claudio Sillero-Zubiri, Débora L Silvano, Kevin G Smith, Andrew T Smith, Jos Snoeks, Alison J Stattersfield, Andrew J Symes, Andrew B Taber, Bibhab K Talukdar, Helen J Temple, Rob Timmins, Joseph A Tobias, Katerina Tsytsulina, Denis Tweddle, Carmen Ubeda, Sarah V Valenti, Peter Paul van Dijk, Liza M Veiga, Alberto Veloso, David C Wege, Mark Wilkinson, Elizabeth A Williamson, Feng Xie, Bruce E Young, H Resit Akçakaya, Leon Bennun, Tim M Blackburn, Luigi Boitani, Holly T Dublin, Gustavo A B da Fonseca, Claude Gascon, Thomas E Lacher, Georgina M Mace, Susan A Mainka, Jeffery A McNeely, Russell A Mittermeier, Gordon McGregor Reid, Jon Paul Rodriguez, Andrew A Rosenberg, Michael J Samways, Jane Smart, Bruce A Stein, Simon N Stuart
Using data for 25,780 species categorized on the International Union for Conservation of Nature Red List, we present an assessment of the status of the world's vertebrates. One-fifth of species are classified as Threatened, and we show that this figure is increasing: On average, 52 species of mammals, birds, and amphibians move one category closer to extinction each year. However, this overall pattern conceals the impact of conservation successes, and we show that the rate of deterioration would have been at least one-fifth again as much in the absence of these...
December 10, 2010: Science
Tobias L Haas, Christoph H Emmerich, Björn Gerlach, Anna C Schmukle, Stefanie M Cordier, Eva Rieser, Rebecca Feltham, James Vince, Uwe Warnken, Till Wenger, Ronald Koschny, David Komander, John Silke, Henning Walczak
TNF is a key inflammatory cytokine. Using a modified tandem affinity purification approach, we identified HOIL-1 and HOIP as functional components of the native TNF-R1 signaling complex (TNF-RSC). Together, they were shown to form a linear ubiquitin chain assembly complex (LUBAC) and to ubiquitylate NEMO. We show that LUBAC binds to ubiquitin chains of different linkage types and that its recruitment to the TNF-RSC is impaired in TRADD-, TRAF2-, and cIAP1/2- but not in RIP1- or NEMO-deficient MEFs. Furthermore, the E3 ligase activity of cIAPs, but not TRAF2, is required for HOIL-1 recruitment to the TNF-RSC...
December 11, 2009: Molecular Cell
Christine G Elsik, Ross L Tellam, Kim C Worley, Richard A Gibbs, Donna M Muzny, George M Weinstock, David L Adelson, Evan E Eichler, Laura Elnitski, Roderic Guigó, Debora L Hamernik, Steve M Kappes, Harris A Lewin, David J Lynn, Frank W Nicholas, Alexandre Reymond, Monique Rijnkels, Loren C Skow, Evgeny M Zdobnov, Lawrence Schook, James Womack, Tyler Alioto, Stylianos E Antonarakis, Alex Astashyn, Charles E Chapple, Hsiu-Chuan Chen, Jacqueline Chrast, Francisco Câmara, Olga Ermolaeva, Charlotte N Henrichsen, Wratko Hlavina, Yuri Kapustin, Boris Kiryutin, Paul Kitts, Felix Kokocinski, Melissa Landrum, Donna Maglott, Kim Pruitt, Victor Sapojnikov, Stephen M Searle, Victor Solovyev, Alexandre Souvorov, Catherine Ucla, Carine Wyss, Juan M Anzola, Daniel Gerlach, Eran Elhaik, Dan Graur, Justin T Reese, Robert C Edgar, John C McEwan, Gemma M Payne, Joy M Raison, Thomas Junier, Evgenia V Kriventseva, Eduardo Eyras, Mireya Plass, Ravikiran Donthu, Denis M Larkin, James Reecy, Mary Q Yang, Lin Chen, Ze Cheng, Carol G Chitko-McKown, George E Liu, Lakshmi K Matukumalli, Jiuzhou Song, Bin Zhu, Daniel G Bradley, Fiona S L Brinkman, Lilian P L Lau, Matthew D Whiteside, Angela Walker, Thomas T Wheeler, Theresa Casey, J Bruce German, Danielle G Lemay, Nauman J Maqbool, Adrian J Molenaar, Seongwon Seo, Paul Stothard, Cynthia L Baldwin, Rebecca Baxter, Candice L Brinkmeyer-Langford, Wendy C Brown, Christopher P Childers, Timothy Connelley, Shirley A Ellis, Krista Fritz, Elizabeth J Glass, Carolyn T A Herzig, Antti Iivanainen, Kevin K Lahmers, Anna K Bennett, C Michael Dickens, James G R Gilbert, Darren E Hagen, Hanni Salih, Jan Aerts, Alexandre R Caetano, Brian Dalrymple, Jose Fernando Garcia, Clare A Gill, Stefan G Hiendleder, Erdogan Memili, Diane Spurlock, John L Williams, Lee Alexander, Michael J Brownstein, Leluo Guan, Robert A Holt, Steven J M Jones, Marco A Marra, Richard Moore, Stephen S Moore, Andy Roberts, Masaaki Taniguchi, Richard C Waterman, Joseph Chacko, Mimi M Chandrabose, Andy Cree, Marvin Diep Dao, Huyen H Dinh, Ramatu Ayiesha Gabisi, Sandra Hines, Jennifer Hume, Shalini N Jhangiani, Vandita Joshi, Christie L Kovar, Lora R Lewis, Yih-Shin Liu, John Lopez, Margaret B Morgan, Ngoc Bich Nguyen, Geoffrey O Okwuonu, San Juana Ruiz, Jireh Santibanez, Rita A Wright, Christian Buhay, Yan Ding, Shannon Dugan-Rocha, Judith Herdandez, Michael Holder, Aniko Sabo, Amy Egan, Jason Goodell, Katarzyna Wilczek-Boney, Gerald R Fowler, Matthew Edward Hitchens, Ryan J Lozado, Charles Moen, David Steffen, James T Warren, Jingkun Zhang, Readman Chiu, Jacqueline E Schein, K James Durbin, Paul Havlak, Huaiyang Jiang, Yue Liu, Xiang Qin, Yanru Ren, Yufeng Shen, Henry Song, Stephanie Nicole Bell, Clay Davis, Angela Jolivet Johnson, Sandra Lee, Lynne V Nazareth, Bella Mayurkumar Patel, Ling-Ling Pu, Selina Vattathil, Rex Lee Williams, Stacey Curry, Cerissa Hamilton, Erica Sodergren, David A Wheeler, Wes Barris, Gary L Bennett, André Eggen, Ronnie D Green, Gregory P Harhay, Matthew Hobbs, Oliver Jann, John W Keele, Matthew P Kent, Sigbjørn Lien, Stephanie D McKay, Sean McWilliam, Abhirami Ratnakumar, Robert D Schnabel, Timothy Smith, Warren M Snelling, Tad S Sonstegard, Roger T Stone, Yoshikazu Sugimoto, Akiko Takasuga, Jeremy F Taylor, Curtis P Van Tassell, Michael D Macneil, Antonio R R Abatepaulo, Colette A Abbey, Virpi Ahola, Iassudara G Almeida, Ariel F Amadio, Elen Anatriello, Suria M Bahadue, Fernando H Biase, Clayton R Boldt, Jeffery A Carroll, Wanessa A Carvalho, Eliane P Cervelatti, Elsa Chacko, Jennifer E Chapin, Ye Cheng, Jungwoo Choi, Adam J Colley, Tatiana A de Campos, Marcos De Donato, Isabel K F de Miranda Santos, Carlo J F de Oliveira, Heather Deobald, Eve Devinoy, Kaitlin E Donohue, Peter Dovc, Annett Eberlein, Carolyn J Fitzsimmons, Alessandra M Franzin, Gustavo R Garcia, Sem Genini, Cody J Gladney, Jason R Grant, Marion L Greaser, Jonathan A Green, Darryl L Hadsell, Hatam A Hakimov, Rob Halgren, Jennifer L Harrow, Elizabeth A Hart, Nicola Hastings, Marta Hernandez, Zhi-Liang Hu, Aaron Ingham, Terhi Iso-Touru, Catherine Jamis, Kirsty Jensen, Dimos Kapetis, Tovah Kerr, Sari S Khalil, Hasan Khatib, Davood Kolbehdari, Charu G Kumar, Dinesh Kumar, Richard Leach, Justin C-M Lee, Changxi Li, Krystin M Logan, Roberto Malinverni, Elisa Marques, William F Martin, Natalia F Martins, Sandra R Maruyama, Raffaele Mazza, Kim L McLean, Juan F Medrano, Barbara T Moreno, Daniela D Moré, Carl T Muntean, Hari P Nandakumar, Marcelo F G Nogueira, Ingrid Olsaker, Sameer D Pant, Francesca Panzitta, Rosemeire C P Pastor, Mario A Poli, Nathan Poslusny, Satyanarayana Rachagani, Shoba Ranganathan, Andrej Razpet, Penny K Riggs, Gonzalo Rincon, Nelida Rodriguez-Osorio, Sandra L Rodriguez-Zas, Natasha E Romero, Anne Rosenwald, Lillian Sando, Sheila M Schmutz, Libing Shen, Laura Sherman, Bruce R Southey, Ylva Strandberg Lutzow, Jonathan V Sweedler, Imke Tammen, Bhanu Prakash V L Telugu, Jennifer M Urbanski, Yuri T Utsunomiya, Chris P Verschoor, Ashley J Waardenberg, Zhiquan Wang, Robert Ward, Rosemarie Weikard, Thomas H Welsh, Stephen N White, Laurens G Wilming, Kris R Wunderlich, Jianqi Yang, Feng-Qi Zhao
To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness...
April 24, 2009: Science
Glenn J Tattersall, Rebecca M Gerlach
Most animals, including reptiles, lower body temperature (Tb) under hypoxic conditions. Numerous physiological and behavioural traits significant to the regulation of Tb are altered by hypoxia in ways that suggest an orchestrated adjustment of Tb at a new and lower regulated level. We examined this matter in bearded dragons, Pogona vitticeps, a species of reptile that naturally exhibits open mouth gaping at high temperatures, presumably in order to promote evaporation and thus prevent or avoid further increases in Tb...
September 2005: Journal of Experimental Biology
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