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Rebecca gerlach

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https://www.readbyqxmd.com/read/28579318/the-zebrafish-kidney-mutant-zeppelin-reveals-that-brca2-fancd1-is-essential-for-pronephros-development
#1
Paul T Kroeger, Bridgette E Drummond, Rachel Miceli, Michael McKernan, Gary F Gerlach, Amanda N Marra, Annemarie Fox, Kristen K McCampbell, Ignaty Leshchiner, Adriana Rodriguez-Mari, Ruth BreMiller, Ryan Thummel, Alan J Davidson, John Postlethwait, Wolfram Goessling, Rebecca A Wingert
The zebrafish kidney is conserved with other vertebrates, making it an excellent genetic model to study renal development. The kidney collects metabolic waste using a blood filter with specialized epithelial cells known as podocytes. Podocyte formation is poorly understood but relevant to many kidney diseases, as podocyte injury leads to progressive scarring and organ failure. zeppelin (zep) was isolated in a forward screen for kidney mutants and identified as a homozygous recessive lethal allele that causes reduced podocyte numbers, deficient filtration, and fluid imbalance...
June 1, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28535745/expanding-beyond-individualism-engaging-critical-perspectives-on-occupation
#2
Alison J Gerlach, Gail Teachman, Debbie Laliberte-Rudman, Rebecca M Aldrich, Suzanne Huot
BACKGROUND: Perspectives that individualize occupation are poorly aligned with socially responsive and transformative occupation-focused research, education, and practice. Their predominant use in occupational therapy risks the perpetuation, rather than resolution, of occupational inequities. AIM: In this paper, we problematize taken-for-granted individualistic analyses of occupation and illustrate how critical theoretical perspectives can reveal the ways in which structural factors beyond an individual's immediate control and environment shape occupational possibilities and occupational engagement...
May 23, 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28325656/the-angiovac-device-and-its-anesthetic-implications
#3
REVIEW
Harish Ram, Rebecca M Gerlach, Antonio Hernandez Conte, Danny Ramzy, Ashley R Jaramillo-Huff, Neal S Gerstein
No abstract text is available yet for this article.
December 18, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28277246/robotic-mitral-valve-repair-with-right-ventricular-pacing-induced-ventricular-fibrillatory-arrest
#4
Andrew Hollatz, Husam H Balkhy, Mark A Chaney, Peter J Neuburger, Rebecca M Gerlach, T Sloane Guy
No abstract text is available yet for this article.
June 18, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27612930/mercury-concentrations-in-alaska-pacific-halibut-muscle-relative-to-stable-isotopes-of-c-and-n-and-other-biological-variables
#5
Rebecca Bentzen, J Margaret Castellini, Robert Gerlach, Claude Dykstra, Todd O'Hara
Total mercury concentrations ([THg]), δ(15)N and δ(13)C values were determined in muscle of 693 Pacific halibut caught in International Pacific Halibut Commission setline surveys in Alaska (2002-2011). Project goals were to evaluate whether 1) δ(15)N and δ(13)C varied with region, age, sex and length of halibut, and 2) muscle [THg] varied with δ(15)N and δ(13)C (feeding ecology) while accounting for sex, length, and region. Variation in [THg] was explained, in part, by halibut feeding ecology as [THg] increased with trophic position (increasing δ(15)N)...
December 15, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/26891391/transesophageal-echocardiogram-guided-percutaneous-angiovac-extraction-of-a-right-atrial-embolus
#6
Rebecca M Gerlach, Danny Ramzy, Lorraine Lubin, Antonio Hernandez Conte
No abstract text is available yet for this article.
March 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/26384634/case-9%C3%A2-2015-anesthetic-management-of-a-patient-with-esophago-pericardial-fistula-complicating-atrial-fibrillation-radiofrequency-ablation
#7
Michael Essandoh, Andrew J Otey, Juan Crestanello, Jonathan Keshishian, Patrick G Brady, Rebecca M Gerlach
No abstract text is available yet for this article.
October 2015: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/26274386/microbead-implantation-in-the-zebrafish-embryo
#8
Gary F Gerlach, Elvin E Morales, Rebecca A Wingert
The zebrafish has emerged as a valuable genetic model system for the study of developmental biology and disease. Zebrafish share a high degree of genomic conservation, as well as similarities in cellular, molecular, and physiological processes, with other vertebrates including humans. During early ontogeny, zebrafish embryos are optically transparent, allowing researchers to visualize the dynamics of organogenesis using a simple stereomicroscope. Microbead implantation is a method that enables tissue manipulation through the alteration of factors in local environments...
2015: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/25980595/case-7-2015-perioperative-considerations-for-a-cardiac-paraganglioma-not-just-another-cardiac-mass
#9
Rebecca M Gerlach, Adam B Barrus, Danny Ramzy, Antonio Hernandez Conte, Swapnil Khoche, Sharon L McCartney, Madhav Swaminathan
No abstract text is available yet for this article.
August 2015: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/25625641/a-novel-selective-and-orally-bioavailable-nav-1-8-channel-blocker-pf-01247324-attenuates-nociception-and-sensory-neuron-excitability
#10
Claire Elizabeth Payne, Adam R Brown, Jonathon W Theile, Alexandre J C Loucif, Aristos J Alexandrou, Mathew D Fuller, John H Mahoney, Brett M Antonio, Aaron C Gerlach, David M Printzenhoff, Rebecca L Prime, Gillian Stockbridge, Anthony J Kirkup, Anthony W Bannon, Steve England, Mark L Chapman, Sharan Bagal, Rosemarie Roeloffs, Uma Anand, Praveen Anand, Peter J Bungay, Mark Kemp, Richard P Butt, Edward B Stevens
BACKGROUND AND PURPOSE: NaV 1.8 ion channels have been highlighted as important molecular targets for the design of low MW blockers for the treatment of chronic pain. Here, we describe the effects of PF-01247324, a new generation, selective, orally bioavailable Nav 1.8 channel blocker of novel chemotype. EXPERIMENTAL APPROACH: The inhibition of Nav 1.8 channels by PF-01247324 was studied using in vitro patch-clamp electrophysiology and the oral bioavailability and antinociceptive effects demonstrated using in vivo rodent models of inflammatory and neuropathic pain...
May 2015: British Journal of Pharmacology
https://www.readbyqxmd.com/read/25602449/cardiac-rupture-from-blunt-chest-trauma-diagnosed-on-transesophageal-echocardiography
#11
Rebecca Gerlach, David Mark, Anujan Poologaindran, Rob Tanzola
No abstract text is available yet for this article.
February 2015: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/25460834/temporal-and-spatial-expression-of-tight-junction-genes-during-zebrafish-pronephros-development
#12
Robert McKee, Gary F Gerlach, Jonathan Jou, Christina N Cheng, Rebecca A Wingert
The kidney is comprised of nephrons - epithelial tubes with specialized segments that reabsorb and secrete solutes, perform osmoregulation, and produce urine. Different nephron segments exhibit unique combinations of ion channels, transporter proteins, and cell junction proteins that govern permeability between neighboring cells. The zebrafish pronephros is a valuable model to study the mechanisms of vertebrate nephrogenesis, but many basic features of segment gene expression in renal progenitors and mature nephrons have not been characterized...
November 2014: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/25446529/zebrafish-pronephros-tubulogenesis-and-epithelial-identity-maintenance-are-reliant-on-the-polarity-proteins-prkc-iota-and-zeta
#13
Gary F Gerlach, Rebecca A Wingert
The zebrafish pronephros provides an excellent in vivo system to study the mechanisms of vertebrate nephron development. When and how renal progenitors in the zebrafish embryo undergo tubulogenesis to form nephrons is poorly understood, but is known to involve a mesenchymal to epithelial transition (MET) and the acquisition of polarity. Here, we determined the precise timing of these events in pronephros tubulogenesis. As the ternary polarity complex is an essential regulator of epithelial cell polarity across tissues, we performed gene knockdown studies to assess the roles of the related factors atypical protein kinase C iota and zeta (prkcι, prkcζ)...
December 15, 2014: Developmental Biology
https://www.readbyqxmd.com/read/24205363/knockdown-of-scf-skp2-function-causes-double-parked-accumulation-in-the-nucleus-and-dna-re-replication-in-drosophila-plasmatocytes
#14
Paul T Kroeger, Douglas A Shoue, Frank M Mezzacappa, Gary F Gerlach, Rebecca A Wingert, Robert A Schulz
In Drosophila, circulating hemocytes are derived from the cephalic mesoderm during the embryonic wave of hematopoiesis. These cells are contributed to the larva and persist through metamorphosis into the adult. To analyze this population of hemocytes, we considered data from a previously published RNAi screen in the hematopoietic niche, which suggested several members of the SCF complex play a role in lymph gland development. eater-Gal4;UAS-GFP flies were crossed to UAS-RNAi lines to knockdown the function of all known SCF complex members in a plasmatocyte-specific fashion, in order to identify which members are novel regulators of plasmatocytes...
2013: PloS One
https://www.readbyqxmd.com/read/24014448/kidney-organogenesis-in-the-zebrafish-insights-into-vertebrate-nephrogenesis-and-regeneration
#15
REVIEW
Gary F Gerlach, Rebecca A Wingert
Vertebrates form a progressive series of up to three kidney organs during development-the pronephros, mesonephros, and metanephros. Each kidney derives from the intermediate mesoderm and is comprised of conserved excretory units called nephrons. The zebrafish is a powerful model for vertebrate developmental genetics, and recent studies have illustrated that zebrafish and mammals share numerous similarities in nephron composition and physiology. The zebrafish embryo forms an architecturally simple pronephros that has two nephrons, and these eventually become a scaffold onto which a mesonephros of several hundred nephrons is constructed during larval stages...
September 2013: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/23687236/echo-rounds-intraoperative-diagnosis-of-transient-pseudo-severe-aortic-stenosis
#16
Rebecca M Gerlach, Rob Tanzola, Rene Allard
No abstract text is available yet for this article.
July 2013: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/23681721/unrecognized-tamponade-diagnosed-pre-induction-by-focused-echocardiography
#17
Rebecca M Gerlach, Tarit K Saha, Rene V Allard, Rob C Tanzola
PURPOSE: We report a case of unrecognized cardiac tamponade diagnosed pre-induction by focused transthoracic echocardiography (TTE). The value of focused perioperative TTE, the anesthetic implications of Churg-Strauss syndrome, and the diagnosis of cardiac tamponade are discussed. CLINICAL FEATURES: A 58-yr-old man with a history of severe asymptomatic aortic stenosis presented for elective endoscopic sinus surgery for intractable nasal polyps with recurrent sinusitis...
August 2013: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/23327924/inflammatory-neovascularization-during-graft-versus-host-disease-is-regulated-by-%C3%AE-v-integrin-and-mir-100
#18
Franziska Leonhardt, Sebastian Grundmann, Martin Behe, Franziska Bluhm, Rebecca A Dumont, Friederike Braun, Melpomeni Fani, Katarina Riesner, Gabriele Prinz, Anne-Kathrin Hechinger, Ulrike V Gerlach, Heide Dierbach, Olaf Penack, Annette Schmitt-Gräff, Jürgen Finke, Wolfgang A Weber, Robert Zeiser
Acute graft-versus-host disease (GvHD) is a complex process involving endothelial damage and neovascularization. Better understanding of the pathophysiology of neovascularization during GvHD could help to target this process while leaving T-cell function intact. Under ischemic conditions, neovascularization is regulated by different micro RNAs (miRs), which potentially play a role in inflamed hypoxic GvHD target organs. We observed strong neovascularization in the murine inflamed intestinal tract (IT) during GvHD...
April 25, 2013: Blood
https://www.readbyqxmd.com/read/21897357/dissection-of-the-adult-zebrafish-kidney
#19
Gary F Gerlach, Lauran N Schrader, Rebecca A Wingert
Researchers working in the burgeoning field of adult stem cell biology seek to understand the signals that regulate the behavior and function of stem cells during normal homeostasis and disease states. The understanding of adult stem cells has broad reaching implications for the future of regenerative medicine. For example, better knowledge about adult stem cell biology can facilitate the design of therapeutic strategies in which organs are triggered to heal themselves or even the creation of methods for growing organs in vitro that can be transplanted into humans...
2011: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/21841493/early-glycemic-control-in-critically-ill-patients-with-burn-injury
#20
Claire V Murphy, Rebecca Coffey, Charles H Cook, Anthony T Gerlach, Sidney F Miller
Glucose management in patients with burn injury is often difficult because of their hypermetabolic state with associated hyperglycemia, hyperinsulinemia, and insulin resistance. Recent studies suggest that time to glycemic control is associated with improved outcomes. The authors sought to determine the influence of early glycemic control on the outcomes of critically ill patients with burn injury. A retrospective analysis was performed at the Ohio State University Medical Center. Patients hospitalized with burn injury were enrolled if they were admitted to the intensive care unit between March 1, 2006, and February 28, 2009...
November 2011: Journal of Burn Care & Research: Official Publication of the American Burn Association
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