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Regan berg

Efstathios Karamanos, Kenji Inaba, Regan J Berg, Shelby Resnick, Obi Okoye, Sophoclis Alexopoulos, Konstantinos Chouliaras, Demetrios Demetriades
BACKGROUND: Aging has been associated with increasing common bile duct (CBD) diameter and reported as independently predictive of the likelihood of choledocolithiasis. These associations are controversial with uncertain diagnostic utility in patients presenting with symptomatic disease. The current study examined the relationship between age, CBD size, and the diagnostic probability of choledocolithiasis. METHODS: Symptomatic patients undergoing evaluation for suspected choledocolithiasis from January 2008 to February 2011 were reviewed...
2017: Digestive Surgery
Nicole Mansfield, Kenji Inaba, Regan Berg, Elizabeth Beale, Elizabeth Benjamin, Lydia Lam, Kazuhide Matsushima, Demetrios Demetriades
BACKGROUND: Early pancreatic dysfunction after resection in trauma has not been well characterized. The objective of this study was to examine the incidence and clinical impact of new-onset endocrine and exocrine dysfunction after pancreatic resection for trauma. METHODS: All patients sustaining a pancreatic injury from 1996 to 2013 were identified. Patients with preinjury diabetes were excluded. Survivors were divided into three groups according to the extent of anatomic resection-distal, proximal, or total pancreatectomy...
March 2017: Journal of Trauma and Acute Care Surgery
C G E van Noordwijk, Wilco C E P Verberk, Hans Turin, Theodoor Heijerman, Kees Alders, Wouter Dekoninck, Karsten Hannig, Eugenie Regan, Stephen McCormack, Mark J F Brown, Eva Remke, Henk Siepel, Matty P Berg, Dries Bonte
In the face of ongoing habitat fragmentation, species-area relationships (SARs) have gained renewed interest and are increasingly used to set conservation priorities. An important question is how large habitat areas need to be to optimize biodiversity conservation. The relationship between area and species richness is explained by colonization-extinction dynamics, whereby smaller sites harbor smaller populations, which are more prone to extinction than the larger populations sustained by larger sites. These colonization-extinction dynamics are predicted to vary with trophic rank, habitat affinity, and dispersal ability of the species...
February 2015: Ecology
Regan J Berg, Kenji Inaba, Obi Okoye, Efstathios Karamanos, Aaron Strumwasser, Konstantinos Chouliaras, Pedro G Teixeira, Demetrios Demetriades
BACKGROUND: Thoracoabdominal firearm injuries present major diagnostic and therapeutic challenges because of the risk for potential injury in multiple anatomic cavities and the attendant dilemma of determining the need for and correct sequencing of cavitary intervention. Injury patterns, management strategies, and outcomes of thoracoabdominal firearm trauma remain undescribed across a large population. METHODS: All patients with thoracoabdominal firearm injury admitted to a major Level I trauma center during a 16-year period were reviewed...
November 2014: Journal of Trauma and Acute Care Surgery
Regan J Berg, Kenji Inaba, Maura Sullivan, Obi Okoye, Stefano Siboni, Michael Minneti, Pedro G Teixeira, Demetrios Demetriades
BACKGROUND: Increasing ambient temperature to prevent intraoperative patient hypothermia remains widely advocated despite unconvincing evidence of efficacy. Heat stress is associated with decreased cognitive and psychomotor performance across multiple tasks but remains unexamined in an operative context. We assessed the impact of increased ambient temperature on laparoscopic operative performance and surgeon cognitive stress. STUDY DESIGN: Forty-two performance measures were obtained from 21 surgery trainees participating in the counter-balanced, within-subjects study protocol...
January 2015: Surgery
Regan J Berg, Kenji Inaba, Obi Okoye, Jason Pasley, Pedro G Teixeira, Michael Esparza, Demetrios Demetriades
INTRODUCTION: Selective non-operative management (NOM) is standard of care for clinically stable patients with blunt splenic trauma and expectant management approaches are increasingly utilised in penetrating abdominal trauma, including in the setting of solid organ injury. Despite this evolution of clinical practice, little is known about the safety and efficacy of NOM in penetrating splenic injury. METHODS: Trauma registry and medical record review identified all consecutive patients presenting to LAC+USC Medical Center with penetrating splenic injury between January 2001 and December 2011...
September 2014: Injury
Regan J Berg, Efstathios Karamanos, Kenji Inaba, Obi Okoye, Pedro G Teixeira, Demetrios Demetriades
BACKGROUND: Penetrating thoracoabdominal trauma, with potential injury to two anatomic cavities, significantly challenges surgical management, yet this injury pattern has not been reviewed across a large patient series. METHODS: The trauma registry of a major level 1 center was queried for all adult patients admitted with thoracoabdominal stab wounds between January 1996 and December 2011. RESULTS: The study identified 617 patients; 11% arrived hypotensive (systolic blood pressure < 90 mm Hg), 6...
February 2014: Journal of Trauma and Acute Care Surgery
Jason Pasley, Regan J Berg, Kenji Inaba
Evaluation of patients after penetrating neck injury has evolved over time. Previously, location of injury and symptoms were used to determine management. The contemporary management of penetrating neck injuries relies on physical examination. Patients with hard signs of vascular or aerodigestive tract injury require immediate operation, regardless of location of injury. Those with no signs can be observed. For the remainder with soft signs, multidetector computed tomographic angiography (MDCTA) is a highly sensitive and specific screening modality for evaluating the vasculature and aerodigestive structures in the neck...
July 2012: Rambam Maimonides Medical Journal
Regan J Berg, Kenji Inaba, Gustavo Recinos, Galinos Barmparas, Pedro G Teixeira, Chrysanthos Georgiou, David Shatz, Peter Rhee, Demetrios Demetriades
BACKGROUND: In asymptomatic patients with penetrating thoracic trauma and a normal initial chest x-ray, successive prospective trials have decreased the minimum observation period required for exclusion of significant injury from 6 to 3 h. Despite the quality of these studies, this interval remains arbitrary and the true requisite observation time for safe discharge remains unknown. The current study evaluates the ability of "early" repeat chest x-ray, at intervals approaching 1 h, to exclude clinically significant injury...
June 2013: World Journal of Surgery
Regan J Berg, Obi Okoye, Kenji Inaba, Agathoklis Konstantinidis, Bernardino Branco, Erin Meisel, Galinos Barmparas, Demetrios Demetriades
As a group, the extremities are the most commonly injured anatomic region in nonfatal firearm trauma and are associated with high rates of vascular and bony injury. This study examines the epidemiology, incidence and distribution of firearm-related extremity trauma and the relationship between injury pattern and local or systemic complications. Review of the National Trauma Databank identified 6987 patients with isolated extremity firearm injury. Epidemiologic data, injury pattern incidence, and local and systemic complications were reviewed...
December 2012: American Surgeon
Kenji Inaba, Regan Berg, Galinos Barmparas, Peter Rhee, Gregory J Jurkovich, Gustavo Recinos, Pedro G Teixeira, Demetrios Demetriades
BACKGROUND: Although uncomfortable for the operating team, trauma operating room (OR) temperatures have traditionally been kept warm in an attempt to mitigate intraoperative heat loss. The purpose of this study was to examine how ambient OR temperatures impact core temperature in patients undergoing emergent surgery for trauma. METHODS: Injured adult patients requiring emergent surgery at a Level 1 trauma center were prospectively enrolled between July 2008 and January 2010...
December 2012: Journal of Trauma and Acute Care Surgery
Regan J Berg, Obi Okoye, Pedro G Teixeira, Kenji Inaba, Demetrios Demetriades
OBJECTIVES: To examine the specific injuries, need for operative intervention, and clinical outcomes of patients with blunt thoracoabdominal trauma. DESIGN: Trauma registry and medical record review. SETTING: Level I trauma center in Los Angeles, California. PATIENTS: All patients with thoracoabdominal injuries from January 1996 to December 2010. MAIN OUTCOME MEASURES: Injuries, incidence and type of operative intervention, clinical outcomes, and risk factors for mortality...
June 2012: Archives of Surgery
Carl A Anderson, Gabrielle Boucher, Charlie W Lees, Andre Franke, Mauro D'Amato, Kent D Taylor, James C Lee, Philippe Goyette, Marcin Imielinski, Anna Latiano, Caroline Lagacé, Regan Scott, Leila Amininejad, Suzannah Bumpstead, Leonard Baidoo, Robert N Baldassano, Murray Barclay, Theodore M Bayless, Stephan Brand, Carsten Büning, Jean-Frédéric Colombel, Lee A Denson, Martine De Vos, Marla Dubinsky, Cathryn Edwards, David Ellinghaus, Rudolf S N Fehrmann, James A B Floyd, Timothy Florin, Denis Franchimont, Lude Franke, Michel Georges, Jürgen Glas, Nicole L Glazer, Stephen L Guthery, Talin Haritunians, Nicholas K Hayward, Jean-Pierre Hugot, Gilles Jobin, Debby Laukens, Ian Lawrance, Marc Lémann, Arie Levine, Cecile Libioulle, Edouard Louis, Dermot P McGovern, Monica Milla, Grant W Montgomery, Katherine I Morley, Craig Mowat, Aylwin Ng, William Newman, Roel A Ophoff, Laura Papi, Orazio Palmieri, Laurent Peyrin-Biroulet, Julián Panés, Anne Phillips, Natalie J Prescott, Deborah D Proctor, Rebecca Roberts, Richard Russell, Paul Rutgeerts, Jeremy Sanderson, Miquel Sans, Philip Schumm, Frank Seibold, Yashoda Sharma, Lisa A Simms, Mark Seielstad, A Hillary Steinhart, Stephan R Targan, Leonard H van den Berg, Morten Vatn, Hein Verspaget, Thomas Walters, Cisca Wijmenga, David C Wilson, Harm-Jan Westra, Ramnik J Xavier, Zhen Z Zhao, Cyriel Y Ponsioen, Vibeke Andersen, Leif Torkvist, Maria Gazouli, Nicholas P Anagnou, Tom H Karlsen, Limas Kupcinskas, Jurgita Sventoraityte, John C Mansfield, Subra Kugathasan, Mark S Silverberg, Jonas Halfvarson, Jerome I Rotter, Christopher G Mathew, Anne M Griffiths, Richard Gearry, Tariq Ahmad, Steven R Brant, Mathias Chamaillard, Jack Satsangi, Judy H Cho, Stefan Schreiber, Mark J Daly, Jeffrey C Barrett, Miles Parkes, Vito Annese, Hakon Hakonarson, Graham Radford-Smith, Richard H Duerr, Séverine Vermeire, Rinse K Weersma, John D Rioux
Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1...
March 2011: Nature Genetics
S G J Mochrie, A H Mack, L Regan
A transfer matrix method is described for the conformational spread (CS) model of allosteric cooperativity within a one-dimensional arrangement of four-state binding sites. Each such binding site can realize one of two possible conformational states. Each of these states can either bind ligand or not bind ligand. Thus, analytical expressions that are exact within the context of the CS model are derived for the grand partition function, for the mean fraction of binding sites occupied by ligand versus ligand concentration, and for the mean fraction of binding sites in a given allosteric state versus ligand concentration...
September 2010: Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
J Gravel, A Berg, M Bradley, A Cacace, D Campbell, L Dalzell, J DeCristofaro, E Greenberg, S Gross, M Orlando, J Pinheiro, J Regan, L Spivak, F Stevens, B Prieve
OBJECTIVE: To examine differences among various test protocols on the fail rate at hospital discharge for infants in the well-baby nursery (WBN) and neonatal intensive care unit (NICU) who received hearing screening through a universal newborn hearing screening demonstration project. DESIGN: The outcomes of several screening protocols were examined. Two technologies were used: transient evoked otoacoustic emissions (TEOAEs) alone or in combination with the auditory brain stem response (ABR)...
April 2000: Ear and Hearing
L Dalzell, M Orlando, M MacDonald, A Berg, M Bradley, A Cacace, D Campbell, J DeCristofaro, J Gravel, E Greenberg, S Gross, J Pinheiro, J Regan, L Spivak, F Stevens, B Prieve
OBJECTIVE: To determine the ages of hearing loss identification, hearing aid fitting, and enrollment in early intervention through a multi-center, state-wide universal newborn hearing screening project. DESIGN: Universal newborn hearing screening was conducted at eight hospitals across New York State. All infants who did not bilaterally pass hearing screening before discharge were recalled for outpatient retesting. Inpatient screening and outpatient rescreening were done with transient evoked otoacoustic emissions and/or auditory brain stem response testing...
April 2000: Ear and Hearing
B Prieve, L Dalzell, A Berg, M Bradley, A Cacace, D Campbell, J DeCristofaro, J Gravel, E Greenberg, S Gross, M Orlando, J Pinheiro, J Regan, L Spivak, F Stevens
OBJECTIVE: To investigate outpatient outcome measures of a multi-center, state-wide, universal newborn hearing screening project. DESIGN: Eight hospitals participated in a 3-yr, funded project. Each hospital designed its own protocol using common criteria for judging whether an infant passed a hearing screening. Infants were tested in the hospital, and those either failing the in-hospital screening or who were not tested in the hospital (missed) were asked to return 4 to 6 wk after hospital discharge for outpatient rescreening...
April 2000: Ear and Hearing
L Spivak, L Dalzell, A Berg, M Bradley, A Cacace, D Campbell, J DeCristofaro, J Gravel, E Greenberg, S Gross, M Orlando, J Pinheiro, J Regan, F Stevens, B Prieve
OBJECTIVE: To evaluate the feasibility of universal newborn hearing screening by examining inpatient outcome measures from 8 hospitals located in geographically diverse areas of New York State over a 3-yr period. DESIGN: Funding was provided by the New York State Department of Health to implement predischarge hearing screening programs in the neonatal intensive care units (NICUs) and well-baby nurseries (WBNs) of eight hospitals. Various screening protocols including transient evoked otoacoustic emissions alone or in combination with conventional auditory brain stem response or screening auditory brain stem response were implemented by each site...
April 2000: Ear and Hearing
D B Elliott, M A Bullimore
PURPOSE: To gather information regarding the reliability, discriminative ability, and validity of disability glare tests. METHODS: The following glare tests were evaluated: the Miller-Nadler, Vistech MCT8000, Berkeley, van den Berg Straylightmeter, and the Brightness Acuity Tester used with the Pelli-Robson and Regan charts. Three test evaluation criteria were used: (1) repeatability--comparing test scores on two visits; (2) discriminative ability--the tests' ability to differentiate between young and old subjects and between old normal and cataract subjects; (3) validity--comparing cataract test scores with the reference standard of the van den Berg Straylightmeter...
January 1993: Investigative Ophthalmology & Visual Science
P G Berge, A Wilhelm, H Schriewer, G Wüst
Serum-sialyltransferase activity was measured in serum samples of 116 patients with malignant tumors of various origins and different clinical stages using asialo-fetuin as the acceptor and cytidine-5'-mono-phospho[14C]sialic acid as the donor. Only patients with metastatic tumors had significantly elevated serum-sialyltransferase levels. Increased enzyme activity was also associated with rheumatoid arthritis and with acute hepatitis, whereas no significant alteration of enzyme activity was observed in cystic fibrosis patients...
May 3, 1982: Klinische Wochenschrift
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