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https://www.readbyqxmd.com/read/29049540/feasibility-process-and-outcomes-of-cardiovascular-clinical-trial-data-sharing-a-reproduction-analysis-of-the-smart-af-trial
#1
Hawkins C Gay, Abigail S Baldridge, Mark D Huffman
Importance: Data sharing is as an expanding initiative for enhancing trust in the clinical research enterprise. Objective: To evaluate the feasibility, process, and outcomes of a reproduction analysis of the THERMOCOOL SMARTTOUCH Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation (SMART-AF) trial using shared clinical trial data. Design, Setting, and Participants: A reproduction analysis of the SMART-AF trial was performed using the data sets, data dictionary, case report file, and statistical analysis plan from the original trial accessed through the Yale Open Data Access Project using the SAS Clinical Trials Data Transparency platform...
October 18, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29016769/safety-and-efficiency-of-porous-tip-contact-force-catheter-for-drug-refractory-symptomatic-paroxysmal-atrial-fibrillation-ablation-results-from-the-smart-sf-trial
#2
Larry A Chinitz, Daniel P Melby, Francis E Marchlinski, Craig Delaughter, Robert S Fishel, George Monir, Anshul M Patel, Douglas N Gibson, Charles A Athill, Lee Ming Boo, Robert Stagg, Andrea Natale
Aims: THERMOCOOL SMARTTOUCH® SF Catheter is a new contact-force (CF)-sensing catheter with 56-hole porous tip designed for improved cooling and reduced fluid delivery compared with a standard 6-hole open-irrigated catheter. The SMART SF study examined the periprocedural safety, acute effectiveness, and procedural efficiency of the catheter for drug-refractory symptomatic paroxysmal atrial fibrillation (PAF) ablation. Methods and results: The prospective, open-label, non-randomized SMART-SF was conducted at 17 US sites...
August 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28863247/self-powered-pulse-sensor-for-antidiastole-of-cardiovascular-disease
#3
Han Ouyang, Jingjing Tian, Guanglong Sun, Yang Zou, Zhuo Liu, Hu Li, Luming Zhao, Bojing Shi, Yubo Fan, Yifan Fan, Zhong Lin Wang, Zhou Li
Cardiovascular diseases are the leading cause of death globally; fortunately, 90% of cardiovascular diseases are preventable by long-term monitoring of physiological signals. Stable, ultralow power consumption, and high-sensitivity sensors are significant for miniaturized wearable physiological signal monitoring systems. Here, this study proposes a flexible self-powered ultrasensitive pulse sensor (SUPS) based on triboelectric active sensor with excellent output performance (1.52 V), high peak signal-noise ratio (45 dB), long-term performance (10(7) cycles), and low cost price...
September 1, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28853247/activatable-clinical-fluorophore-quencher-antibody-pairs-as-dual-molecular-probes-for-the-enhanced-specificity-of-image-guided-surgery
#4
Girgis Obaid, Bryan Q Spring, Shazia Bano, Tayyaba Hasan
The emergence of fluorescently labeled therapeutic antibodies has given rise to molecular probes for image-guided surgery. However, the extraneous interstitial presence of an unbound and nonspecifically accumulated probe gives rise to false-positive detection of tumor tissue and margins. Thus, the concept of tumor-cell activation of smart probes provides a potentially superior mechanism of delineating tumor margins as well as small tumor deposits. The combination of molecular targeting with intracellular activation circumvents the presence of extracellular, nonspecific signals of targeted probe accumulation...
August 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28760211/implantable-cardiac-monitors-in-high-risk-post-infarction-patients-with-cardiac-autonomic-dysfunction-and-moderately-reduced-left-ventricular-ejection-fraction-design-and-rationale-of-the-smart-mi-trial
#5
RANDOMIZED CONTROLLED TRIAL
Wolfgang Hamm, Konstantinos D Rizas, Lukas von Stülpnagel, Nikolay Vdovin, Steffen Massberg, Stefan Kääb, Axel Bauer
BACKGROUND: Most deaths after myocardial infarction (MI) occur in patients with left ventricular ejection fraction (LVEF) >35%, for whom no specific prophylactic strategies exist. Deceleration capacity (DC) of heart rate and periodic repolarization dynamics (PRD) are noninvasive electrophysiological markers depending on the vagal and sympathetic tone. The combination of abnormal DC and/or PRD identifies a new high-risk group among postinfarction patients with LVEF 36%-50%. This new high-risk group has similar characteristics with respect to prognosis and patient numbers to those of the established high-risk group identified by LVEF ≤ 35%...
August 2017: American Heart Journal
https://www.readbyqxmd.com/read/28752228/the-dx-af-study-a-prospective-multicenter-randomized-controlled-trial-comparing-vdd-icd-to-vvi-icd-in-detecting-sub-clinical-atrial-fibrillation-in-defibrillator-patients
#6
Mohammed Shurrab, Amir Janmohamed, Jean-François Sarrazin, Felix Ayala-Paredes, Marcio Sturmer, Randall Williams, Satish Toal, Chris Lane, Kevin E Thorpe, Jeff S Healey, Eugene Crystal
PURPOSE: Atrial fibrillation (AF) is the most common cardiac dysrhythmia. Appropriate detection of AF and early initiation of oral anticoagulation therapy are critical to reduce the risk of stroke. Patients with implantable cardioverter defibrillators (ICD) are at high risk of developing AF. The purpose of the Dx-AF study is to demonstrate that a novel single-lead VDD-ICD system (Linox smart S DX) will facilitate adequate recognition of sub-clinical AF and ultimately stroke prevention with a comparable safety profile in comparison to VVI-ICD...
July 27, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28391210/atrial-fibrillation-detection-via-accelerometer-and-gyroscope-of-a-smartphone
#7
Olli Lahdenoja, Tero Hurnanen, Zuhair Iftikhar, Sami Nieminen, Timo Knuutila, Antti Saraste, Tuomas Kiviniemi, Tuija Vasankari, Juhani Airaksinen, Mikko Pankaala, Tero Koivisto
We present a smartphone-only solution for the detection of Atrial Fibrillation (AFib), which utilizes the builtin accelerometer and gyroscope sensors (Inertial Measurement Unit, IMU) in the detection. Depending on the patient's situation, it is possible to use the developed smartphone application either regularly or occasionally for making a measurement of the subject. The smartphone is placed on the chest of the patient who is adviced to lay down and perform a non-invasive recording, while no external sensors are needed...
April 5, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27875477/smartphone-based-arrhythmia-monitoring
#8
Paul Garabelli, Stavros Stavrakis, Sunny Po
The use of smartphones for arrhythmia monitoring is another leap for ECG utilization and arrhythmia detection - effectively taking the technology to any smartphone user. Smart wearable technology, while very common, is limited mostly to activity tracking and exercise motivation. Rhythm strip generating smartphone products (Kardia Mobile by AliveCor and ECG Check by Cardiac Designs) are more powerful at arrhythmia detection than wearable monitors. These products, which have been studied in a variety of situations, rely on an external device with metal sensors to create a rhythm strip, which is usually Lead I...
January 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/27778352/long-term-stability-and-clinical-utility-of-amplified-atrial-electrograms-in-a-single-lead-icd-system-with-floating-atrial-electrodes
#9
Nicole E Worden, Musab Alqasrawi, Alexander Mazur
BACKGROUND: Available atrial electrograms in implantable cardioverter defibrillators (ICDs) improve arrhythmia diagnosis, allow monitoring for atrial fibrillation, and may reduce the risk of inappropriate therapies. A recently introduced ICD system using a single-lead with floating atrial electrodes provides diagnostic capability of a dual-chamber system without placing an additional lead. Data on long-term clinical performance of this system are limited. METHODS: We retrospectively analyzed data from 35 consecutive patients implanted with Biotronik VR-T DX devices and Linox(Smart) DX leads...
December 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27733471/-smart-solutions-for-paroxysmal-atrial-fibrillation
#10
Lars Grieten, Thijs Vandenberk, Dieter Nuyens
No abstract text is available yet for this article.
July 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27541655/on-vs-off-pump-coronary-artery-bypass-grafting-a-systematic-review-and-meta-analysis
#11
REVIEW
Gudrun Dieberg, Neil A Smart, Nicola King
BACKGROUND: To reduce complications during coronary artery bypass grafting (CABG) off-pump CABG was introduced; however, results have been mixed. The aim of this work was to conduct a systematic review and meta-analysis of off-pump vs. on-pump CABG. METHODS: To identify potential studies systematic searches were carried out using various databases. The search strategy included the key concepts of "cardiopulmonary bypass" AND "coronary artery bypass grafting" AND "off pump"...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27468731/radiofrequency-ablation-of-atrial-fibrillation-nonrandomized-comparison-of-circular-versus-point-by-point-smart-ablation-for-achieving-circumferential-pulmonary-vein-isolation-and-curing-arrhythmic-symptoms
#12
Raphael Rosso, Ehud Chorin, Yuval Levi, Ori Rogowski, Sami Viskin
INTRODUCTION: Pulmonary vein isolation (PVI) with radiofrequency (RF) ablation is now standard care for atrial fibrillation (AF). New improvements in PVI techniques include use of catheters that measure contact-force and circular ablation catheters. These techniques have not been compared. METHODS AND RESULTS: We compared the success rate of circumferential pulmonary vein isolation (CPVI) with: (1) "point by point" RF using an irrigated tip ablation catheter with "smart touch" contact-force; (2) irrigated nMARQ circular ablation catheter in 86 patients with AF...
July 29, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27371660/smart-detection-of-atrial-fibrillation%C3%A2
#13
Lian Krivoshei, Stefan Weber, Thilo Burkard, Anna Maseli, Noe Brasier, Michael Kühne, David Conen, Thomas Huebner, Andrea Seeck, Jens Eckstein
Aims: Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice, and its paroxysmal nature makes its detection challenging. In this trial, we evaluated a novel App for its accuracy to differentiate between patients in AF and patients in sinus rhythm (SR) using the plethysmographic sensor of an iPhone 4S and the integrated LED only. Methods and results: For signal acquisition, we used an iPhone 4S, positioned with the camera lens and LED light on the index fingertip...
May 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27334627/a-proposal-for-monitoring-patients-with-heart-failure-via-smart-phone-technology-based-electrocardiograms
#14
John E Madias
The ubiquitous smart phone/device technology (SPT) has enabled the safe acquisition/transmission (A/T) of clinical and laboratory patient data, including the electrocardiogram (ECG). SPT-based A/T of the ECG has been found useful in the detection of atrial fibrillation, in monitoring of the QTc interval, in patients undergoing antiarrhythmic drug loading, and in management of patients with acute ST-elevation myocardial infarction. Previous work has shown a relationship between changes in the voltage of the ECG QRS complexes, with perturbations in the edematous state of various etiologies, including heart failure (HF)...
September 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/27216543/an-update-on-laboratory-measurements-of-dabigatran-smart-specific-and-calibrated-dedicated-assays-for-measuring-anti-iia-activity-in-plasma
#15
REVIEW
Jean Amiral, Claire Dunois, Cédric Amiral, Jerard Seghatchian
Use of Direct Oral Anticoagulants (DOACs) is continuously increasing for clinical application. The first product released was Dabigatran, which was proposed for many preventive and curative applications, especially for prevention of stroke in patients with non-valvular atrial fibrillation. Although measurement of Dabigatran Anti-IIa activity in plasma is not requested on a routine basis, in some situations its measurement is clinically useful. Especially, before an emergency surgery in treated patients, where its presence at high concentrations, which will expose the patient at an increased bleeding risk, has to be excluded...
June 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27152144/impact-of-computed-tomography-image-and-contact-force-technology-on-catheter-ablation-for-atrial-fibrillation
#16
Ibrahim Marai, Mahmoud Suleiman, Miry Blich, Jonathan Lessick, Sobhi Abadi, Monther Boulos
AIM: To investigate the impact of using computed tomography (CT) and contact force (CF) technology on recurrence of atrial tachyarrhythmia after atrial fibrillation (AF) ablation. METHODS: This non-randomized study included 2 groups of patients. All patients had symptomatic recurrent paroxysmal or persistent AF and were treated with at least 1 anti arrhythmic medication or intolerant to medication. The first group included 33 patients who underwent circumferential pulmonary veins isolation (PVI) for AF during 2012 and 2013 guided by CT image integration (Cartomerge, Biosense Webster, Diamond Bar, CA, United States) of left atrium and pulmonary veins into an electroanatomic mapping (EAM) system (CT group) using standard irrigated radiofrequency catheter (ThermoCool, Carto, Biosense Webster, Diamond Bar, CA, United States) or irrigated catheter with integrated CF sensor (Smart Touch, Carto, Biosense Webster, Diamond Bar, CA, United States)...
April 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27145055/drug-coated-balloon-venoplasty-for-in-stent-restenosis-in-a-patient-with-recurrent-pulmonary-vein-stenosis-post-ablation-for-atrial-fibrillation-initial-experience-with-a-new-treatment-technique
#17
Jonathan Rosenberg, Westby G Fisher, Mayra Guerrero, Steve Smart, Justin Levisay, Ted Feldman, Michael Salinger
Pulmonary vein stenosis (PVS) is an uncommon but serious complication following radiofrequency ablation for atrial fibrillation. Occurrence of this complication has risen with increased rates of ablation procedures, with >50,000 AF ablation procedures performed per year, and can occur within weeks to months post procedure. Currently, the main therapies for PVS include percutaneous interventions with balloon angioplasty and stenting, but these treatments are complicated by a high rate of restenosis. The optimal treatment for recurrent pulmonary vein in-stent restenosis has not been determined...
May 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27043858/rhythm-based-heartbeat-duration-normalization-for-atrial-fibrillation-detection
#18
Md Saiful Islam, Nassim Ammour, Naif Alajlan, Hatim Aboalsamh
BACKGROUND: Screening of atrial fibrillation (AF) for high-risk patients including all patients aged 65 years and older is important for prevention of risk of stroke. Different technologies such as modified blood pressure monitor, single lead ECG-based finger-probe, and smart phone using plethysmogram signal have been emerging for this purpose. All these technologies use irregularity of heartbeat duration as a feature for AF detection. We have investigated a normalization method of heartbeat duration for improved AF detection...
May 1, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/26847074/smart-watches-a-potential-challenger-to-the-implantable-loop-recorder
#19
REVIEW
Alexander Carpenter, Antonio Frontera
The newest generation of smart-watches offer heart rate monitoring technology via photoplethysmography, a technology shown to demonstrate impressive ability in diagnosing arrhythmias including atrial fibrillation. Combining such technology with the portability, connectivity and other location and activity tracking features smart-watches could represent a powerful new tool in extended non-invasive arrhythmia detection. The technology itself, including potential uses and limitations, is discussed. There is a need for further software development but crucially, further work into clarifying the diagnostic accuracy of such technology...
June 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/26777209/monophasic-and-biphasic-shock-for-transthoracic-conversion-of-atrial-fibrillation-systematic-review-and-network-meta-analysis
#20
REVIEW
José Francisco Secorun Inácio, Michele dos Santos Gomes da Rosa, Julie Shah, Jeferson Rosário, João Ricardo Nickenig Vissoci, André Luiz Langer Manica, Clarissa Garcia Rodrigues
OBJECTIVES: Conduct a systematic review of the literature to compare the efficacy of different biphasic and monophasic shock waveforms technologies for transthoracic cardioversion of Atrial Fibrillation (AF). METHODS: We searched PubMed, EMBASE, The Cochrane Library, LILACS and ClinicalTrials.gov databases for randomized clinical trials comparing two or more defibrillation waveforms when performing elective transthoracic cardioversion of AF. The outcomes assessed were 1st shock success, overall success, cumulative energy and number of shocks to restore Normal Sinus Rhythm...
March 2016: Resuscitation
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