Guoqiang Wang, Ryan Guasp, Sangeena Salam, Edward Chuang, Andrés Morera, Anna J Smart, David Jimenez, Sahana Shekhar, Ilija Melentijevic, Ken C Nguyen, David H Hall, Barth D Grant, Monica Driscoll
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate extrusion of large vesicles, such as exophers produced by proteostressed C. elegans touch neurons, are poorly understood. Here we document that mechanical force can significantly potentiate exopher extrusion from proteostressed neurons. Exopher production from the C. elegans ALMR neuron peaks at adult day 2 or 3, coinciding with the C...
November 16, 2023: bioRxiv