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https://www.readbyqxmd.com/read/29044575/investigation-of-the-effect-of-astaxanthin-on-alveolar-bone-loss-in-experimental-periodontitis
#1
H Balci Yuce, A Lektemur Alpan, F Gevrek, H Toker
BACKGROUND AND OBJECTIVE: Astaxanthin is a keto-carotenoid that has a strong antioxidant effect. The purpose of this study was to evaluate the effects of astaxanthin on alveolar bone loss and histopathological changes in ligature-induced periodontitis in rats. MATERIAL AND METHODS: Wistar rats were divided into four experimental groups: non-ligated (C, n = 6); ligature only (L, n = 6); ligature and astaxanthin (1 mg/kg/day astaxanthin, AS1 group, n = 8); ligature and astaxanthin (5 mg/kg/day astaxanthin, AS5 group, n = 8)...
October 17, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29044431/computational-imaging-of-sperm-locomotion
#2
Mustafa Ugur Daloglu, Aydogan Ozcan
Not only essential for scientific research, but also in the analysis of male fertility and for animal husbandry, sperm tracking and characterization techniques have been greatly benefiting from computational imaging. Digital image sensors, in combination with optical microscopy tools and powerful computers, have enabled the use of advanced detection and tracking algorithms that automatically map sperm trajectories and calculate various motility parameters across large data sets. Computational techniques are driving the field even further, facilitating the development of unconventional sperm imaging and tracking methods that do not rely on standard optical microscopes and objective lenses, which limit the field of view and volume of the semen sample that can be imaged...
August 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29043803/identification-of-privileged-antichlamydial-natural-products-by-a-ligand-based-strategy
#3
Elina Karhu, Janne Isojärvi, Pia Vuorela, Leena Hanski, Adyary Fallarero
The obligate intracellular pathogen Chlamydia pneumoniae remains a difficult target for antimicrobial therapy. Owing to the permeability barrier placed by bacterial and host vacuolar membranes, as well as the propensity of the bacterium for persistent infections, treatment failures are common. Despite the urgent need for new antichlamydial compounds, their discovery is challenged by the technically demanding assay procedures and lack of validated targets. An alternative strategy of using naturally occurring compounds and their derivatives against C...
October 18, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29043636/analysis-of-de-novo-telomere-addition-by-southern-blot
#4
Diego Bonetti, Maria Pia Longhese
Telomere length is maintained in most eukaryotes by the action of a specialized enzyme, the telomerase. However, the complexity of mechanisms regulating telomeric DNA length as well as the heterogeneity in length of each telomere in a population of cells has made it very difficult to understand how telomerase is regulated in vivo. Here, we describe a method developed in Saccharomyces cerevisiae to monitor the addition of telomeric sequences to a single newly generated telomere in vivo. The primary strain consists of a HO endonuclease cleavage site that is placed directly adjacent to an 81-base-pair stretch of telomeric DNA inserted into the ADH4 locus of chromosome VII...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29042544/origami-based-tunable-truss-structures-for-non-volatile-mechanical-memory-operation
#5
Hiromi Yasuda, Tomohiro Tachi, Mia Lee, Jinkyu Yang
Origami has recently received significant interest from the scientific community as a method for designing building blocks to construct metamaterials. However, the primary focus has been placed on their kinematic applications by leveraging the compactness and auxeticity of planar origami platforms. Here, we present volumetric origami cells-specifically triangulated cylindrical origami (TCO)-with tunable stability and stiffness, and demonstrate their feasibility as non-volatile mechanical memory storage devices...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29041914/analysis-of-the-genome-of-the-new-zealand-giant-collembolan-holacanthella-duospinosa-sheds-light-on-hexapod-evolution
#6
Chen Wu, Melissa D Jordan, Richard D Newcomb, Neil J Gemmell, Sarah Bank, Karen Meusemann, Peter K Dearden, Elizabeth J Duncan, Sefanie Grosser, Kim Rutherford, Paul P Gardner, Ross N Crowhurst, Bernd Steinwender, Leah K Tooman, Mark I Stevens, Thomas R Buckley
BACKGROUND: The New Zealand collembolan genus Holacanthella contains the largest species of springtails (Collembola) in the world. Using Illumina technology we have sequenced and assembled a draft genome and transcriptome from Holacanthella duospinosa (Salmon). We have used this annotated assembly to investigate the genetic basis of a range of traits critical to the evolution of the Hexapoda, the phylogenetic position of H. duospinosa and potential horizontal gene transfer events. RESULTS: Our genome assembly was ~375 Mbp in size with a scaffold N50 of ~230 Kbp and sequencing coverage of ~180×...
October 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29041365/condensation-phenomenon-detection-through-surface-plasmon-resonance
#7
Joyce Ibrahim, Mostafa Al Masri, Colette Veillas, Frédéric Celle, Serge Cioulachtjian, Isabelle Verrier, Frédéric Lefèvre, Olivier Parriaux, Yves Jourlin
The aim of this work is to optically detect the condensation of acetone vapor on an aluminum plate cooled down in a two-phase environment (liquid/vapor). Sub-micron period aluminum based diffraction gratings with appropriate properties, exhibiting a highly sensitive plasmonic response, were successfully used for condensation experiments. A shift in the plasmonic wavelength resonance has been measured when acetone condensation on the aluminum surface takes place due to a change of the surrounding medium close to the surface, demonstrating that the surface modification occurs at the very beginning of the condensation phenomenon...
October 2, 2017: Optics Express
https://www.readbyqxmd.com/read/29041254/mediated-coupling-of-surface-plasmon-polaritons-by-a-moving-electron-beam
#8
Sen Gong, Min Hu, Renbin Zhong, Tao Zhao, Chao Zhang, Shenggang Liu
The mediated coupling of surface plasmon polaritons (SPPs) by a parallel moving electron beam is demonstrated in this paper. The theoretical analysis shows that the electron beam excited spoof surface plasmon polaritons (SSPs) on the grating placed above the metal films play the role as the excitation source in the mediated coupling. The numerical calculations and particle-in-cell simulations demonstrate the significant advantages of the SSPs mediately coupled SPPs in contrast with that coupled by the parallel moving electron beam directly...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29040749/cdc42-regulates-the-cellular-localization-of-cdc42ep1-in-controlling-neural-crest-cell-migration
#9
Cohen Shlomi, Daniel T Kovari, Wenbin Wei, Rebecca Keate, Jennifer E Curtis, Shuyi Nie
The member of Rho family of small GTPases Cdc42 plays important and conserved roles in cell polarity and motility. The Cdc42ep family proteins have been identified to bind to Cdc42, yet how they interact with Cdc42 to regulate cell migration remains to be elucidated. In this study, we focus on Cdc42ep1, which is expressed predominantly in the highly migratory neural crest cells in frog embryos. Through morpholino-mediated knockdown, we show that Cdc42ep1 is required for the migration of cranial neural crest cells...
October 6, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29040520/clinical-implications-of-mitochondrial-dna-quantification-on-pregnancy-outcomes-a-blinded-prospective-non-selection-study
#10
Elpida Fragouli, Caroline McCaffrey, Krithika Ravichandran, Katharina Spath, James A Grifo, Santiago Munné, Dagan Wells
STUDY QUESTION: Can quantification of mitochondrial DNA (mtDNA) in trophectoderm (TE) biopsy samples provide information concerning the viability of a blastocyst, potentially enhancing embryo selection and improving IVF treatment outcomes? SUMMARY ANSWER: This study demonstrated that euploid blastocysts of good morphology, but with high mtDNA levels had a greatly reduced implantation potential. WHAT IS KNOWN ALREADY: Better methods of embryo selection leading to IVF outcome improvement are necessary, as the transfer of chromosomally normal embryos of high morphological grade cannot guarantee the establishment of an ongoing pregnancy...
September 23, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29039889/robot-assisted-single-port-radical-nephrectomy-and-cholecystectomy-description-and-technical-aspects
#11
Francisco Hidelbrando Alves Mota Filho, Luis Felipe Sávio, Rafael Eiji Sakata, Renato Fidelis Ivanovic, Marco Antonio Nunes da Silva, Ronaldo Maia, Carlo Passerotti
INTRODUCTION: Robot-Assisted Single Site Radical Nephrectomy (RASS-RN) has been reported by surgeons in Europe and United States (1-3). To our best knowledge this video presents the first RASS-RN with concomitant cholecystectomy performed in Latin America. CASE: A 66 year-old renal transplant male due to chronic renal failure presented with an incidental 1.3cm nodule in the upper pole of the right kidney. In addition, symptomatic gallbladder stones were detected...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29038831/recovery-from-sublethal-damage-and-potentially-lethal-damage-proton-beam-irradiation-vs-x%C3%A2-ray-irradiation
#12
Shingo Hashimoto, Chikao Sugie, Hiromitsu Iwata, Hiroyuki Ogino, Chihiro Omachi, Keisuke Yasui, Jun-Etsu Mizoe, Yuta Shibamoto
PURPOSE: In order to clarify the biological response of tumor cells to proton beam irradiation, sublethal damage recovery (SLDR) and potentially lethal damage recovery (PLDR) induced after proton beam irradiation at the center of a 10 cm spread-out Bragg peak (SOBP) were compared with those seen after X‑ray irradiation. METHODS: Cell survival was determined by a colony assay using EMT6 and human salivary gland tumor (HSG) cells. First, two doses of 4 Gy/GyE (Gray equivalents, GyE) were given at an interfraction interval of 0-6 h...
October 16, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29037975/modular-cell-based-platform-for-high-throughput-identification-of-compounds-that-inhibit-a-viral-interferon-antagonist-of-choice
#13
Andri Vasou, Christina Paulus, Janina Narloch, Zoe O Gage, Marie-Anne Rameix-Welti, Jean-François Eléouët, Michael Nevels, Richard E Randall, Catherine S Adamson
Viral interferon (IFN) antagonists are a diverse class of viral proteins that counteract the host IFN response, which is important for controlling viral infections. Viral IFN antagonists are often multifunctional proteins that perform vital roles in virus replication beyond IFN antagonism. The critical importance of viral IFN antagonists is highlighted by the fact that almost all viruses encode one of these proteins. Inhibition of viral IFN antagonists has the potential to exert pleiotropic antiviral effects and thus this important protein class represents a diverse plethora of novel therapeutic targets...
October 13, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29037376/the-small-heat-shock-protein-hsp27-present-understanding-and-future-prospects
#14
REVIEW
Manish Kumar Singh, Bechan Sharma, Pramod K Tiwari
Heat shock proteins are important for maintaining protein homeostasis and cell survival. Among different classes of highly conserved Hsps, low molecular weight Hsps (sHsps) have significant place, particularly Hsp27, whose role has been demonstrated in wide range of biological processes, including development, immunity, diseases and therapy. In this review, the structure and functions of Hsp27 and related genes, their role in different cellular processes as well as in stress tolerance, is highlighted.
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29037191/ascorbic-acid-alters-cell-fate-commitment-of-human-neural-progenitors-in-a-wnt-%C3%AE-catenin-ros-signaling-dependent-manner
#15
Tareck Rharass, Margareta Lantow, Adam Gbankoto, Dieter G Weiss, Daniela Panáková, Stéphanie Lucas
BACKGROUND: Improving the neuronal yield from in vitro cultivated neural progenitor cells (NPCs) is an essential challenge in transplantation therapy in neurological disorders. In this regard, Ascorbic acid (AA) is widely used to expand neurogenesis from NPCs in cultures although the mechanisms of its action remain unclear. Neurogenesis from NPCs is regulated by the redox-sensitive WNT/β-catenin signaling pathway. We therefore aimed to investigate how AA interacts with this pathway and potentiates neurogenesis...
October 16, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29036460/radon-exhalation-from-soil-and-its-dependence-from-environmental-parameters
#16
Jinmin Yang, Maximilian Buchsteiner, Josef Salvamoser, Josef Irlinger, Qiuju Guo, Jochen Tschiersch
An automatic measuring apparatus called exhalometer for measurement of the radon exhalation rate from soil is introduced. It consists of a pneumatic driven accumulation chamber with an open bottom, a PC-based control system, six Lucas cells for radon measurement and sensors for environmental parameters. It allows moving the accumulation chamber and hereby opening or closing it. The exhalation rate is determined through the increase of radon in the accumulation chamber. For studying exhalation and the affecting factors, the exhalometer was placed at an undisturbed meadow for the entire year of 2015...
September 19, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29033925/caco-2-invasion-by-cronobacter-sakazakii-and-salmonella-enterica-exposed-to-drying-and-heat-treatments-in-dried-state-in-milk-powder
#17
Emilie Lang, Stéphane Guyot, Pablo Alvarez-Martin, Jean-Marie Perrier-Cornet, Patrick Gervais
Due to the ability of foodborne pathogens to survive in low moisture food, the decontamination of milk powder is an important issue in food protection. The safety of food products is, however, not always insured and the different steps in the processing of food involve physiological and metabolic changes in bacteria. Among these changes, virulence properties may also be affected. In this study, the effect of drying and successive thermal treatments on the invasion capacity of Salmonella Typhimurium, Salmonella Senftenberg, and Cronobacter sakazakii was assessed...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29033920/dna-repair-and-photoprotection-mechanisms-of-overcoming-environmental-ultraviolet-radiation-exposure-in-halophilic-archaea
#18
REVIEW
Daniel L Jones, Bonnie K Baxter
Halophilic archaea push the limits of life at several extremes. In particular, they are noted for their biochemical strategies in dealing with osmotic stress, low water activity and cycles of desiccation in their hypersaline environments. Another feature common to their habitats is intense ultraviolet (UV) radiation, which is a challenge that microorganisms must overcome. The consequences of high UV exposure include DNA lesions arising directly from bond rearrangement of adjacent bipyrimidines, or indirectly from oxidative damage, which may ultimately result in mutation and cell death...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29033834/tc299423-a-novel-agonist-for-nicotinic-acetylcholine-receptors
#19
Teagan R Wall, Brandon J Henderson, George Voren, Charles R Wageman, Purnima Deshpande, Bruce N Cohen, Sharon R Grady, Michael J Marks, Daniel Yohannes, Paul J Kenny, Merouane Bencherif, Henry A Lester
(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2(∗) (α6β2-containing), α4β2(∗), and α3β4(∗) nAChRs, using [(125)I]-epibatidine binding, whole-cell patch-clamp recordings, synaptosomal (86)Rb(+) efflux, [(3)H]-dopamine release, and [(3)H]-acetylcholine release. TC299423 displayed an EC50 of 30-60 nM for α6β2(∗) nAChRs in patch-clamp recordings and [(3)H]-dopamine release assays...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29033542/axitinib-in-the-treatment-of-renal-cell-carcinoma-design-development-and-place-in-therapy
#20
REVIEW
Audrey Bellesoeur, Edith Carton, Jerome Alexandre, Francois Goldwasser, Olivier Huillard
Since 2005, the approved first-line treatment of metastatic renal cell carcinoma consists in tyrosine kinase inhibitors (TKIs) targeting the vascular endothelial growth factor receptors (VEGFRs). Axitinib is an oral second-generation TKI and a potent VEGFR inhibitor with a half maximal inhibitory concentration for the VEGF family receptors 10-fold lower than other TKIs. Axitinib activity in renal cell carcinoma (RCC) patients has been studied in various settings and particularly as second-line treatment. In this setting, axitinib with clinically based dose escalation compared to sorafenib has demonstrated an improvement in progression-free survival in a randomized Phase III trial leading to US Food and Drug Administration approval...
2017: Drug Design, Development and Therapy
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