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MRI contrast agent

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https://www.readbyqxmd.com/read/29775791/an-imaging-biomarker-for-assessing-hepatic-function-in-patients-with-primary-sclerosing-cholangitis
#1
Jennifer Schulze, Henrike Lenzen, Jan B Hinrichs, Burckhardt Ringe, Michael P Manns, Frank Wacker, Kristina I Ringe
BACKGROUND & AIMS: We aimed to evaluate the potential of hepatobiliary phase magnetic resonance imaging (MRI) as parameter for assessment of hepatocellular function in patients with primary sclerosing cholangitis (PSC). METHODS: We collected data from 111 patients (83 male, 28 female; median, 44 years old), from March 2012 through March 2016, with a confirmed diagnosis of PSC who underwent MRI evaluation before and after injection (hepatobiliary phase) of a hepatocyte-specific contrast agent (gadoxetate disodium)...
May 15, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29774188/gadofosveset-enhanced-magnetic-resonance-imaging-as-a-problem-solving-tool-for-diagnosing-colorectal-liver-metastases-a-case-report
#2
Helen Cheung, Paul Karanicolas, Natalie Coburn, Calvin Law, Laurent Milot
Due to significant improvements in morbidity and mortality, surgery with curative intent is now the standard of care for patients with colorectal liver metastases who are surgical candidates. As a result, highly accurate preoperative per-lesion diagnosis is crucial. However, in some instances, this remains limited with standard techniques, including magnetic resonance imaging (MRI) with conventional contrast agents. Delayed retention of contrast of fibrotic liver metastases on MRI with extracellular contrast agents may mimic the late retention of contrast in hemangiomas and represent a diagnostic pitfall that limits diagnosis...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29774066/caveolae-mediated-mesenchymal-stem-cell-labelling-by-pss-coated-plga-pfob-nano-contrast-agent-for-mri
#3
Hieu Vu Quang, Chi-Chih Chang, Ping Song, Ellen-Margrethe Hauge, Jørgen Kjems
Rationale: Non-invasive tracking of transplanted cells is critical in evaluating delivery, migration and prognosis of cell therapies. Methods: We formulated a nano-contrast agent consisting of a perfluorooctylbromide (PFOB) core within a shell of poly (lactic-co-glycolic acid) (PLGA) followed by a coat of polystyrene sulfonate (PSS) for 19 F MRI. The nano-contrast agent (PSS-NP) was characterised by DLS and the uptake efficiency of the nano-contrast agent (PSS-NP) was tested using flow cytometry, in vitro MRI and confocal microscopy...
2018: Theranostics
https://www.readbyqxmd.com/read/29771932/a-multi-center-preclinical-study-of-gadoxetate-dce-mri-in-rats-as-a-biomarker-of-drug-induced-inhibition-of-liver-transporter-function
#4
Anastassia Karageorgis, Stephen C Lenhard, Brittany Yerby, Mikael F Forsgren, Serguei Liachenko, Edvin Johansson, Mark A Pilling, Richard A Peterson, Xi Yang, Dominic P Williams, Sharon E Ungersma, Ryan E Morgan, Kim L R Brouwer, Beat M Jucker, Paul D Hockings
Drug-induced liver injury (DILI) is a leading cause of acute liver failure and transplantation. DILI can be the result of impaired hepatobiliary transporters, with altered bile formation, flow, and subsequent cholestasis. We used gadoxetate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), combined with pharmacokinetic modelling, to measure hepatobiliary transporter function in vivo in rats. The sensitivity and robustness of the method was tested by evaluating the effect of a clinical dose of the antibiotic rifampicin in four different preclinical imaging centers...
2018: PloS One
https://www.readbyqxmd.com/read/29771534/nitroxyl-modified-tobacco-mosaic-virus-as-a-metal-free-high-relaxivity-mri-and-epr-active-superoxide-sensor
#5
Madushani Dharmarwardana, Andre F Martins, Zhuo Chen, Philip Palacios, Chance M Nowak, Raymond P Welch, Shaobo Li, Michael Andrew Luzuriaga, Leonidas Bleris, Brad S Pierce, A Dean Sherry, Jeremiah J Gassensmith
Superoxide overproduction is known to occur in multiple disease states requiring critical care yet non-invasive detection of superoxide in deep tissue remains a challenge. Herein, we report a metal-free magnetic resonance imaging (MRI) and electron paramagnetic resonance (EPR) active contrast agent prepared by "click conjugating" paramagnetic organic radical contrast agents (ORCAs) to the surface of tobacco mosaic virus (TMV). While ORCAs are known to be reduced in vivo to an MRI/EPR silent state, their oxidation is facilitated specifically by reactive oxygen species-in particular superoxide-and are largely unaffected by peroxides and molecular oxygen...
May 17, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29769077/magnetic-field-distribution-modulation-of-intrathecal-delivered-ketorolac-iron-oxide-nanoparticle-conjugates-produce-excellent-analgesia-for-chronic-inflammatory-pain
#6
Ping-Ching Wu, Dar-Bin Shieh, Hung-Tsung Hsiao, Jeffery Chi-Fei Wang, Ya-Chi Lin, Yen-Chin Liu
BACKGROUND: Nanoparticles have become one of the most promising among the potential materials used for biomedical applications. However, few researchers have focused on their effects on analgesia. Despite the fact that various nanoparticles have been evaluated for drug delivery and MRI imaging contrast enhancement in clinical settings, no reports have investigated the in vivo synergy of ketorolac iron-oxide nanoparticle conjugates to improve the analgesic effect. METHODS: Ketorolac conjugated magnetic iron oxide nanoparticles (Keto-SPIO) were synthesized via two-stage additions of protective agents and chemical co-precipitation...
May 16, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29758239/the-use-of-memri-for-monitoring-central-nervous-system-activity-during-intact-insect-walking
#7
Daniel Knebel, Yaniv Assaf, Amir Ayali
BACKGROUND: Monitoring neuronal activity in the intact behaving animal is most desired in neuroethological research, yet it is rarely straightforward or even feasible. Here we present the use of manganese enhanced magnetic resonance imaging (MEMRI), a technique allowing monitoring the activity of an animal's nervous system during specific behavioral patterns. Using MEMRI we were able to show activity in different ganglia of the central nervous system of intact locusts during walking RESULTS: We injected two groups of locusts with manganese, which serves as a magnetic contrast agent...
May 11, 2018: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29755979/design-and-validation-of-diffusion-mri-models-of-white-matter
#8
Ileana O Jelescu, Matthew D Budde
Diffusion MRI is arguably the method of choice for characterizing white matter microstructure in vivo. Over the typical duration of diffusion encoding, the displacement of water molecules is conveniently on a length scale similar to that of the underlying cellular structures. Moreover, water molecules in white matter are largely compartmentalized which enables biologically-inspired compartmental diffusion models to characterize and quantify the true biological microstructure. A plethora of white matter models have been proposed...
November 28, 2017: Frontiers in Physics
https://www.readbyqxmd.com/read/29753641/consistency-of-normalized-cerebral-blood-volume-values-in-glioblastoma-using-different-leakage-correction-algorithms-on-dynamic-susceptibility-contrast-magnetic-resonance-imaging-data-without-and-with-prebolus
#9
Dennis Hedderich, Anne Kluge, Thomas Pyka, Claus Zimmer, Jan S Kirschke, Benedikt Wiestler, Christine Preibisch
BACKGROUND AND PURPOSE: Several leakage correction algorithms for dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI)-based cerebral blood volume (CBV) measurement have been proposed, and combination with a preload of contrast agent is generally recommended. A single bolus application scheme would largely simplify and facilitate standardized clinical applications, while reducing contrast agent (CA) dose. The aim of this study was, therefore, to investigate whether appropriate leakage correction redundantizes prebolus application by comparing normalized DSC-based CBV (nCBV) measures of two consecutive CA boli...
May 10, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29752484/surveillance-mri-for-the-detection-of-locally-recurrent-ewing-sarcoma-seems-futile
#10
Ömer Kasalak, Amelie Dammann, Hugo J A Adams, Jelle Overbosch, Rudi A J O Dierckx, Paul C Jutte, Thomas C Kwee
PURPOSE: To determine the frequency of locally recurrent Ewing sarcoma on surveillance MRI and the outcome of these patients. MATERIALS AND METHODS: This retrospective single-center study included all patients with newly diagnosed Ewing sarcoma who underwent surveillance MRI of the primary tumor location after primary treatment between 1997 and 2016. RESULTS: Thirty-two patients underwent a total of 176 local surveillance MRI scans, yielding an average of 5...
May 11, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29751253/advances-in-gadolinium-based-mri-contrast-agent-designs-for-monitoring-biological-processes-in-vivo
#11
REVIEW
Jacques Lux, A Dean Sherry
The gadolinium-based contrast agents widely used in diagnostic MRI exams for 30 years are all small molecule agents that distribute into all extracellular spaces in tissues without providing any specific biological information. Although many 'responsive agent' designs have been presented over the past 20 years or so, none have found use in clinical diagnostic medicine at this point. This review summarizes some recent approaches taken to enhance the sensitivity of such gadolinium-based agents, to target them to specific tissue components, and to create new systems for monitoring specific biological processes...
May 8, 2018: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29750031/glypican-1-antibody-conjugated-gd-au-nanoclusters-for-fi-mri-dual-modal-targeted-detection-of-pancreatic-cancer
#12
Xin Huang, Chengqi Fan, Huanhuan Zhu, Wenjun Le, Shaobin Cui, Xin Chen, Wei Li, Fulei Zhang, Yong Huang, Donglu Sh, Zheng Cui, Chengwei Shao, Bingdi Chen
Introduction: Pancreatic cancer (PC) has a poor prognosis with high mortality, due to the lack of effective early diagnostic and prognostic tools. Materials and methods: In order to target and diagnose PC, we developed a dual-modal imaging probe using Glypican-1 (GPC-1) antibody conjugated with Gd-Au nanoclusters (NCs; Gd-Au-NC-GPC-1). GPC-1 is a type of cell surface heparan sulfate proteoglycan, which is often highly expressed in PC. The probe was successfully prepared with a hydrodynamic diameter ranging from 13...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29744935/fast-magnetic-resonance-fingerprinting-for-dynamic-contrast-enhanced-studies-in-mice
#13
Yuning Gu, Charlie Y Wang, Christian E Anderson, Yuchi Liu, He Hu, Mette L Johansen, Dan Ma, Yun Jiang, Ciro Ramos-Estebanez, Susann Brady-Kalnay, Mark A Griswold, Chris A Flask, Xin Yu
PURPOSE: The goal of this study was to develop a fast MR fingerprinting (MRF) method for simultaneous T1 and T2 mapping in DCE-MRI studies in mice. METHODS: The MRF sequences based on balanced SSFP and fast imaging with steady-state precession were implemented and evaluated on a 7T preclinical scanner. The readout used a zeroth-moment-compensated variable-density spiral trajectory that fully sampled the entire k-space and the inner 10 × 10 k-space with 48 and 4 interleaves, respectively...
May 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29744642/gadolinium-deposition-within-the-paediatric-brain-no-increased-intrinsic-t1-weighted-signal-intensity-within-the-dentate-nucleus-following-the-administration-of-a-minimum-of-four-doses-of-the-macrocyclic-agent-gadobutrol
#14
Jonathan R Young, Joe Qiao, Iren Orosz, Noriko Salamon, Mark A Franke, Hyun J Kim, Whitney B Pope
OBJECTIVES: To determine whether repeated administration of the macrocyclic gadolinium-based contrast agent (GBCA) gadobutrol in children is associated with T1-weighted hyperintensity within the dentate nucleus, an imaging surrogate for gadolinium deposition. METHODS: With institutional review board approval, we identified a cohort of eight patients aged 18 years or younger who underwent at least four gadobutrol-enhanced magnetic resonance imaging (MRI) examinations of the brain from 2013 to 2017...
May 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29740121/magnetic-resonance-imaging-provides-evidence-of-glymphatic-drainage-from-human-brain-to-cervical-lymph-nodes
#15
Per Kristian Eide, Svein Are Sirirud Vatnehol, Kyrre Eeg Emblem, Geir Ringstad
Pre-clinical research in rodents provides evidence that the central nervous system (CNS) has functional lymphatic vessels. In-vivo observations in humans, however, are not demonstrated. We here show data on CNS lymphatic drainage to cervical lymph nodes in-vivo by magnetic resonance imaging (MRI) enhanced with an intrathecal contrast agent as a cerebrospinal fluid (CSF) tracer. Standardized MRI of the intracranial compartment and the neck were acquired before and up to 24-48 hours following intrathecal contrast agent administration in 19 individuals...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737953/gadolinium-distribution-in-cerebrospinal-fluid-after-administration-of-a-gadolinium-based-mr-contrast-agent-in-humans
#16
Florian Berger, Rahel A Kubik-Huch, Tilo Niemann, Hans Ruedi Schmid, Michael Poetzsch, Johannes M Froehlich, Jürg H Beer, Michael J Thali, Thomas Kraemer
Purpose To evaluate whether gadolinium penetrates human cerebrospinal fluid (CSF) after MR imaging (MRI) with a gadolinium-based contrast agent (GBCA). Materials and Methods For this retrospective study, the authors analyzed 60 CSF samples from 57 patients (median age, 50 years; range, 3-92 years) who underwent one contrast material-enhanced MRI examination with gadoterate meglumine within 60 days of CSF extraction between January and December 2016. CSF samples from patients who underwent MRI without contrast material administration (n = 22) or those who underwent contrast-enhanced MRI at least 1 year before extraction (n = 2) were analyzed and used as control samples...
May 8, 2018: Radiology
https://www.readbyqxmd.com/read/29737836/intelligent-mno2-cu2-xs-for-multimode-imaging-diagnostic-and-advanced-single-laser-irradiated-photothermal-photodynamic-therapy
#17
Yu Cao, Xiangdan Meng, Dongdong Wang, Kai Zhang, Wenhao Dai, HaiFeng Dong, Xueji Zhang
Lately, photothermal therapy (PTT) and photodynamic therapy (PDT) dual-modal therapy has attracted much attention in cancer therapy as a synergistic therapeutic model. However, the integration of PDT and PTT in single nanoagent for cancer therapy is still a challenging task. Herein, an intelligent MnO2/Cu2-xS-siRNA nanoagent simultaneously overcoming inherent limitations of PDT and PTT with remarkable PTT/PDT therapeutic efficiency enabling multimode accurate tumor imaging diagnostic is designed. We first develop a general method to decorate Cu2-xS on the surface of MnO2 nanosheet (MnO2/Cu2-xS), then, it was loaded with heat shock protein (HSP) 70 siRNA to obtain MnO2/Cu2-xS-siRNA...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29737435/anti-epcam-scfv-gadolinium-chelate-a-novel-targeted-mri-contrast-agent-for-imaging-of-colorectal-cancer
#18
Kannika Khantasup, Pairash Saiviroonporn, Suwatchai Jarussophon, Warangkana Chantima, Tararaj Dharakul
OBJECTIVES: The development of targeted contrast agents for magnetic resonance imaging (MRI) facilitates enhanced cancer imaging and more accurate diagnosis. In the present study, a novel contrast agent was developed by conjugating anti-EpCAM humanized scFv with gadolinium chelate to achieve target specificity. MATERIALS AND METHODS: The material design strategy involved site-specific conjugation of the chelating agent to scFv. The scFv monomer was linked to maleimide-DTPA via unpaired cysteine at the scFv C-terminus, followed by chelation with gadolinium (Gd)...
May 8, 2018: Magma
https://www.readbyqxmd.com/read/29736521/electrostatic-self-assembled-nanoparticles-based-on-spherical-polyelectrolyte-brushes-for-magnetic-resonance-imaging
#19
Weiqiao Qian, Qin Zhu, Bing Duan, Weijun Tang, Yuan Yuan, Aiguo Hu
Magnetic resonance imaging (MRI) is one of the most important medical imaging techniques for clinical diagnosis. Contrast agents (CAs) are commonly necessarily used to enhance the imaging quality of MRI and differentiate diseased tissues from normal ones. Herein, we introduced a macromolecular carrier, spherical polyelectrolyte brushes (SPBs), which consists of a solid polystyrene (PS) core and polyacrylic acid (PAA) chains as a brush layer to host Gd(iii) complexes. The cationic Gd(iii) complex Gd-DTPA-NO-C4 was synthesized through a 6-step approach and then formed electrostatic self-assemblies with SPBs to afford magnetic assemblies...
May 8, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29735362/mri-with-gadofosveset-a-potential-marker-for-permeability-in-myocardial-infarction
#20
Begoña Lavin, Andrea Protti, Silvia Lorrio, Xuebin Dong, Alkystis Phinikaridou, René M Botnar, Ajay Shah
BACKGROUND AND AIMS: Acute ischemia is associated with myocardial endothelial damage and microvessel formation, resulting in leakage of plasma albumin into the myocardial extravascular space. In this study, we tested whether an albumin-binding intravascular contrast agent (gadofosveset) allows for improved quantification of myocardial permeability compared to the conventional extracellular contrast agent Gd-DTPA using late gadolinium enhancement (LGE) and T1 mapping in vivo. METHODS: MI was induced in C57BL/6 mice (n = 6) and cardiac magnetic resonance imaging (CMR) was performed at 3, 10 and 21 days post-MI using Gd-DTPA and 24 h later using gadofosveset...
April 25, 2018: Atherosclerosis
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