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https://www.readbyqxmd.com/read/28815859/performance-of-mri-for-suspected-appendicitis-in-pediatric-patients-and-negative-appendectomy-rate-a-systematic-review-and-meta-analysis
#1
Jeong Rye Kim, Chong Hyun Suh, Hee Mang Yoon, Ah Young Jung, Jin Seong Lee, Jung Heon Kim, Jeong-Yong Lee, Young Ah Cho
PURPOSE: To evaluate in pediatric patients the diagnostic performance of magnetic resonance imaging (MRI) for suspected appendicitis and its negative appendectomy rate. MATERIALS AND METHODS: The study involved diagnostic accuracy studies that used MRI for pediatric patients with suspected appendicitis. Various field strengths and sequences were used in each included study. The diagnostic accuracy of MRI in pediatric patients with suspected appendicitis and negative appendectomy rate were assessed...
August 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28814732/dual-contrast-magnetic-resonance-fingerprinting-dc-mrf-a-platform-for-simultaneous-quantification-of-multiple-mri-contrast-agents
#2
Christian E Anderson, Shannon B Donnola, Yun Jiang, Joshua Batesole, Rebecca Darrah, Mitchell L Drumm, Susann M Brady-Kalnay, Nicole F Steinmetz, Xin Yu, Mark A Griswold, Chris A Flask
Injectable Magnetic Resonance Imaging (MRI) contrast agents have been widely used to provide critical assessments of disease for both clinical and basic science imaging research studies. The scope of available MRI contrast agents has expanded over the years with the emergence of molecular imaging contrast agents specifically targeted to biological markers. Unfortunately, synergistic application of more than a single molecular contrast agent has been limited by MRI's ability to only dynamically measure a single agent at a time...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813699/t1-and-t2-mapping-in-cardiology-mapping-the-obscure-object-of-desire
#3
Sophie Mavrogeni, Dimitris Apostolou, Panayiotis Argyriou, Stella Velitsista, Lilika Papa, Stelios Efentakis, Evangelos Vernardos, Mikela Kanoupaki, George Kanoupakis, Athanassios Manginas
The increasing use of cardiovascular magnetic resonance (CMR) is based on its capability to perform biventricular function assessment and tissue characterization without radiation and with high reproducibility. The use of late gadolinium enhancement (LGE) gave the potential of non-invasive biopsy for fibrosis quantification. However, LGE is unable to detect diffuse myocardial disease. Native T1 mapping and extracellular volume fraction (ECV) provide knowledge about pathologies affecting both the myocardium and interstitium that is otherwise difficult to identify...
August 17, 2017: Cardiology
https://www.readbyqxmd.com/read/28812002/image-guided-thermal-ablation-with-mr-based-thermometry
#4
REVIEW
Mingming Zhu, Ziqi Sun, Chin K Ng
Thermal ablation techniques such as radiofrequency, microwave, high intensity focused ultrasound (HIFU) and laser have been used as minimally invasive strategies for the treatment of variety of cancers. MR thermometry methods are readily available for monitoring thermal distribution and deposition in real time, leading to decrease of incidents of normal tissue damage around targeted lesion. HIFU and laser-induced thermal therapy (LITT) are the two widely accepted tumor ablation techniques because of their compatibility with MR systems...
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28811581/the-key-energy-scales-of-gd-based-metallofullerene-determined-by-resonant-inelastic-x-ray-scattering-spectroscopy
#5
Yu-Cheng Shao, L Andrew Wray, Shih-Wen Huang, Yi-Sheng Liu, Wang Song, Shangfeng Yang, Yi-De Chuang, Jinghua Guo, Way-Faung Pong
Endohedral metallofullerenes, formed by encaging Gd inside fullerenes like C80, can exhibit enhanced proton relaxitivities compared with other Gd-chelates, making them the promising contrast agents for magnetic resonance imaging (MRI). However, the underlying key energy scales of Gd x Sc3-x N@C80 (x  =  1-3) remain unclear. Here, we carry out resonant inelastic x-ray scattering (RIXS) experiments on Gd x Sc3-x N@C80 at Gd N 4,5-edges to directly study the electronic structure and spin flip excitations of Gd 4f electrons...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806856/direct-cell-labeling-to-image-transplanted-stem-cells-in-real-time-using-a-dual-contrast-mri-technique
#6
Ethel J Ngen, Yoshinori Kato, Dmitri Artemov
Exogenous direct cell labeling with superparamagnetic iron oxide nanoparticles (SPIONs) is currently the most employed cell-labeling technique for tracking transplanted cells using magnetic resonance imaging (MRI). Although SPION-based cell labeling is effective for monitoring cell delivery and migration, monitoring cell survival is still a challenge. This unit describes an MRI technique that permits detection of the delivery, migration, and death of transplanted cells. This dual-contrast technique involves labeling cells with two different classes of MRI contrast agents, possessing different diffusion coefficients: SPIONs (T2 /T2(*) contrast agents, with lower diffusion coefficients) and gadolinium chelates (T1 contrast agents, with higher diffusion coefficients)...
August 14, 2017: Current Protocols in Stem Cell Biology
https://www.readbyqxmd.com/read/28806257/orbital-hemangiopericytoma-in-68ga-prostate-specific-membrane-antigen-hbed-cc-pet-ct
#7
Jochen Hammes, Carsten Kobe, Ute Hilgenberg, Wolfgang E Lieb, Alexander Drzezga
A 76-year-old man with biochemical relapse of prostate cancer underwent Ga-prostate-specific membrane antigen PET/CT. Besides a local lymph node metastasis, a nodular structure inside the left orbit caudal to the optic nerve showed increased uptake. A metastasis in this location is unlikely. The subsequently performed MRI showed the structure being T1 hypointense, T2 indifferent, and strongly gadolinium contrast agent enhancing. Histopathologic examination after surgical removal identified the tumor as hemangiopericytoma, which rarely occurs in the orbit...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28804578/using-nanoparticles-in-medicine-for-liver-cancer-imaging
#8
REVIEW
Farideh Farokhi Moghadam
One of the most important types of liver cancer is hepatocellular carcinoma (HCC). HCC is the fifth most common cancer, and its correct diagnosis is very important. For the quick diagnosis of HCC, the use of nanoparticles is helpful. The major applications of nanoparticles are in medicine for organ imaging. Two methods of liver imaging are X-ray computed tomography (CT) and magnetic resonance imaging (MRI). In this review, we attempt to summarize some of the contrast agents used in imaging such as superparamagnetic iron oxide nanoparticles (SPIONs) and iron oxide nanoparticles (IONPs), various types of enhanced MRI for the liver, and nanoparticles like gold (AuNPs), which is used to develop novel CT imaging agents...
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28803622/effect-of-hyoscine-butylbromide-on-prostate-multiparametric-mri-anatomical-and-functional-image-quality
#9
R A Slough, I Caglic, N L Hansen, A J Patterson, T Barrett
AIM: To evaluate the effect of the spasmolytic agent hyoscine butylbromide (HBB) on the quality of anatomical and functional imaging of the prostate. MATERIALS AND METHODS: One hundred and seventy-three patients were included in this retrospective study. Eighty-seven patients received intravenous HBB prior to scanning (HBB group) and 86 patients did not (non-HBB group). Multiparametric (mp) 3 T magnetic resonance imaging (MRI) was performed using a 32-channel body coil...
August 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28802623/an-analytical-model-which-determines-the-apparent-t1-for-modified-look-locker-inversion-recovery-analysis-of-the-longitudinal-relaxation-under-the-influence-of-discontinuous-balanced-classical-molli-and-spoiled-gradient-echo-readouts
#10
Thomas Kampf, Theresa Reiter, Wolfgang Rudolf Bauer
Quantitative nuclear magnetic resonance imaging (MRI) shifts more and more into the focus of clinical research. Especially determination of relaxation times without/and with contrast agents becomes the foundation of tissue characterization, e.g. in cardiac MRI for myocardial fibrosis. Techniques which assess longitudinal relaxation times rely on repetitive application of readout modules, which are interrupted by free relaxation periods, e.g. the Modified Look-Locker Inversion Recovery = MOLLI sequence. These discontinuous sequences reveal an apparent relaxation time, and, by techniques extrapolated from continuous readout sequences, a putative real T1 is determined...
August 9, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28802567/nano-sized-and-other-improved-reporters-for-magnetic-resonance-imaging-of-angiogenesis
#11
Simonetta Geninatti Crich, Enzo Terreno, Silvio Aime
Magnetic Resonance Imaging (MRI) enables to provide anatomical, functional and molecular information of pathological angiogenesis when used with properly tailored imaging probes. Functional studies have been the domain of Dynamic Contrast Enhancement (DCE) -MRI protocols from which it is possible to extract quantitative estimations on key parameters such as the volumes of vascular and extracellular compartments and the rates of the bidirectional exchange of the imaging reporters across the endothelial barrier...
August 9, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28802145/ensemble-of-expert-deep-neural-networks-for-spatio-temporal-denoising-of-contrast-enhanced-mri-sequences
#12
A Benou, R Veksler, A Friedman, T Riklin Raviv
Dynamic contrast-enhanced MRI (DCE-MRI) is an imaging protocol where MRI scans are acquired repetitively throughout the injection of a contrast agent. The analysis of dynamic scans is widely used for the detection and quantification of blood-brain barrier (BBB) permeability. Extraction of the pharmacokinetic (PK) parameters from the DCE-MRI concentration curves allows quantitative assessment of the integrity of the BBB functionality. However, curve fitting required for the analysis of DCE-MRI data is error-prone as the dynamic scans are subject to non-white, spatially-dependent and anisotropic noise...
August 2, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28799160/intramuscular-perfusion-response-in-delayed-onset-muscle-soreness-doms-a-quantitative-analysis-with-contrast-enhanced-ultrasound-ceus
#13
Marion Kellermann, Rafael Heiss, Bernd Swoboda, Kolja Gelse, Jürgen Freiwald, Casper Grim, Armin Nagel, Michael Uder, Dane Wildner, Thilo Hotfiel
The purpose of this study was to analyse intramuscular perfusion response in ultrastructural muscle lesions, by applying contrast-enhanced ultrasound (CEUS) to a delayed onset muscle soreness (DOMS) model. Results of this analysis were compared to high-resolution 3 Tesla MRI T2-weighted sequences. 14 healthy participants were recruited. Average perfusion parameters, represented as Peak enhancement (contrast agent inflow) and wash-in area under curve (WiAUC) of the gastrocnemius (GM) and soleus muscle (SM) were assessed before (baseline) and 60 h after inducing DOMS by eccentric exercise...
August 10, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28798327/assessing-cell-nanoparticle-interactions-by-high-content-imaging-of-biocompatible-iron-oxide-nanoparticles-as-potential-contrast-agents-for-magnetic-resonance-imaging
#14
Roxanne Hachani, Martin A Birchall, Mark W Lowdell, Georgios Kasparis, Le D Tung, Bella B Manshian, Stefaan J Soenen, Willy Gsell, Uwe Himmelreich, Codi A Gharagouzloo, Srinivas Sridhar, Nguyen T K Thanh
Stem cell tracking in cellular therapy and regenerative medicine is an urgent need, superparamagnetic iron oxide nanoparticles (IONPs) could be used as contrast agents in magnetic resonance imaging (MRI) that allows visualization of the implanted cells ensuring they reach the desired sites in vivo. Herein, we report the study of the interaction of 3,4-dihydroxyhydrocinnamic acid (DHCA) functionalized IONPs that have desirable properties for T2 - weighted MRI, with bone marrow-derived primary human mesenchymal stem cells (hMSCs)...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28796722/accuracy-and-repeatability-of-automated-injector-versus-manual-administration-of-an-mri-contrast-agent-results-of-a-laboratory-study
#15
Jan Endrikat, Ron Barbati, Marcella Scarpa, Gregor Jost, Arthur E Ned Uber
OBJECTIVE: The aim of this study was to compare flow rates over time and the deviations from the target flow rate of a magnetic resonance imaging contrast agent achieved by an automated injector versus manual injection. MATERIALS AND METHODS: In this laboratory study, the magnetic resonance contrast agent gadobutrol was repeatedly injected by an injector and by 10 experienced technologists. Six scenarios with 2 different target flow rates (1 and 5 mL/s), 2 different contrast volumes (10 and 20 mL), and 2 different intravenous (IV) catheters (22 gauge and 20 gauge) were tested...
August 7, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28794626/folic-acid-functionalized-polyethylenimine-superparamagnetic-iron-oxide-nanoparticles-as-theranostic-agents-for-magnetic-resonance-imaging-and-pd-l1-sirna-delivery-for-gastric-cancer
#16
Xin Luo, Xia Peng, Jingying Hou, Shuyun Wu, Jun Shen, Lingyun Wang
Programmed death ligand-1 (PD-L1), which is highly expressed in gastric cancers, interacts with programmed death-1 (PD-1) on T cells and is involved in T-cell immune resistance. To increase the therapeutic safety and accuracy of PD-1/PD-L1 blockade, RNA interference through targeted gene delivery was performed in our study. We developed folic acid (FA)- and disulfide (SS)-polyethylene glycol (PEG)-conjugated polyethylenimine (PEI) complexed with superparamagnetic iron oxide Fe3O4 nanoparticles (SPIONs) as a siRNA-delivery system for PD-L1 knockdown...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28781820/rare-imaging-appearance-of-adenoid-cystic-carcinoma-of-the-breast-a-case-report
#17
Hongli Wang, Fengtao Liu, Ran Gu, Yong Li, Fengxi Su
Adenoid cystic carcinoma (ACC) of the breast is a rare tumor comprising <0.1% of all breast malignancies. The present study reports the case of a 66-year-old woman who underwent multiple imaging techniques, including mammography, ultrasonography and magnetic resonance imaging (MRI). The patient reported gradual enlargement of a mass in the left breast. Mammography identified a high-density, irregular mass, with nipple retraction. Ultrasonography revealed an irregular, complex cystic and solid mass with an unclear margin in the subareolar region...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28776023/nitroxide-based-macromolecular-contrast-agents-with-unprecedented-transverse-relaxivity-and-stability-for-magnetic-resonance-imaging-of-tumors
#18
Hung V-T Nguyen, Qixian Chen, Joseph T Paletta, Peter Harvey, Yivan Jiang, Hui Zhang, Michael D Boska, M Francesca Ottaviani, Alan Jasanoff, Andrzej Rajca, Jeremiah A Johnson
Metal-free magnetic resonance imaging (MRI) agents could overcome the established toxicity associated with metal-based agents in some patient populations and enable new modes of functional MRI in vivo. Herein, we report nitroxide-functionalized brush-arm star polymer organic radical contrast agents (BASP-ORCAs) that overcome the low contrast and poor in vivo stability associated with nitroxide-based MRI contrast agents. As a consequence of their unique nanoarchitectures, BASP-ORCAs possess per-nitroxide transverse relaxivities up to ∼44-fold greater than common nitroxides, exceptional stability in highly reducing environments, and low toxicity...
July 26, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28771446/micro-hccs-in-rats-with-liver-cirrhosis-paradoxical-effects-with-vascular-disrupting-agent-ca4p
#19
Yewei Liu, Ting Yin, Frederik De Keyzer, Yuanbo Feng, Feng Chen, Jianjun Liu, Shaoli Song, Jie Yu, Vincent Vandecaveye, Johan Swinnen, Guy Bormans, Uwe Himmelreich, Raymond Oyen, Jian Zhang, Gang Huang, Yicheng Ni
We sought to investigate anticancer efficacy of a vascular disrupting agent (VDA) combretastatin A-4 phosphate (CA4P) in relation to tumor size among hepatocellular carcinomas (HCCs) in rats using magnetic resonance imaging (MRI) and postmortem techniques. Nineteen rats with 43 chemically-induced HCCs of 2.8-20.9 mm in size on liver cirrhosis received CA4P intravenously at 10 mg/kg. Tumor-diameter was measured by T2-weighted imaging (T2WI) to define microcancers (< 5 mm) versus larger HCCs. Vascular responses and tissue necrosis were detected by diffusion-weighted imaging (DWI), contrast-enhanced T1-weighted imaging (CE-T1WI) and dynamic contrast enhanced (DCE-) MRI, which were validated by microangiography and histopathology...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28769560/non-immunogenic-dextran-coated-superparamagnetic-iron-oxide-nanoparticles-a-biocompatible-size-tunable-contrast-agent-for-magnetic-resonance-imaging
#20
Harald Unterweger, Christina Janko, Marc Schwarz, László Dézsi, Rudolf Urbanics, Jasmin Matuszak, Erik Őrfi, Tamás Fülöp, Tobias Bäuerle, János Szebeni, Clément Journé, Aldo R Boccaccini, Christoph Alexiou, Stefan Lyer, Iwona Cicha
Iron oxide-based contrast agents have been in clinical use for magnetic resonance imaging (MRI) of lymph nodes, liver, intestines, and the cardiovascular system. Superparamagnetic iron oxide nanoparticles (SPIONs) have high potential as a contrast agent for MRI, but no intravenous iron oxide-containing agents are currently approved for clinical imaging. The aim of our work was to analyze the hemocompatibility and immuno-safety of a new type of dextran-coated SPIONs (SPIONdex) and to characterize these nanoparticles with ultra-high-field MRI...
2017: International Journal of Nanomedicine
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