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https://www.readbyqxmd.com/read/29650819/-a-case-report-of-neuroendocrine-carcinoma-in-the-gall-bladder-showing-recurrence-shortly-after-surgery
#1
Yoshihiro Uchino, Sonofu Taketani, Nobuhisa Hirayu, Koji Shiota, Hironobu Sou, Satoshi Taniwaki, Tetsuo Imamura
A55 -year-old woman with a 10×8mm protuberant gallbladder lesion visited our hospital. To determine possible malignancy, she underwent laparoscopic excision biopsy of the gallbladder, and pathological findings revealed an endocrine carcinoma in the gallbladder. Surgery involved extrahepatic bile duct resection, gallbladder bed resection, and hepatic portal lymph node resection. Recurrence in the peritoneal lymph node was observed in the early postoperative period. Chemotherapy was initiated with cisplatin and irinotecan, and continues 18 months post-operatively...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29577030/eus-guided-gall-bladder-drainage-in-severe-liver-disease-a-single-center-experience-in-critically-ill-cirrhotics
#2
Kapil Dev Jamwal, Manoj Kumar Sharma, Rakhi Maiwall, Barjesh Kumar Sharma, Shiv Kumar Sarin
Background and Aims : Acute calculous cholecystitis with impending gall bladder perforation in severe liver diseases including decompensated cirrhosis and acute-on-chronic liver failure (ACLF) is difficult to manage, due to the procedures such as cholecystectomy and per cutaneous cholecystostomy being associated with high risk and complications in these patients. Methods : Four cases of severe liver disease with acute calculous cholecystitis who presented to the Institute of Liver and Biliary Sciences (New Delhi, India) for further management were included in the study if they underwent endoscopic ultrasound-guided gall bladder drainage (EUS-GBD)...
March 28, 2018: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29527009/phase-ii-study-of-everolimus-rad001-monotherapy-as-first-line-treatment-in-advanced-biliary-tract-cancer-with-biomarker-exploration-the-radichol-study
#3
David K Lau, Rebecca Y Tay, Yvonne H Yeung, Fiona Chionh, Jennifer Mooi, Carmel Murone, Effie Skrinos, Timothy J Price, John M Mariadason, Niall C Tebbutt
BACKGROUND: Advanced biliary tract cancers (BTCs) have a poor prognosis and limited treatment options. This exploratory phase II study aimed to evaluate the activity of the mTOR inhibitor everolimus in advanced BTC and explore prognostic biomarkers. METHODS: Patients with advanced BTCs, who had not received chemotherapy for advanced disease, were enroled to receive everolimus (10 mg daily). The primary endpoint was disease control rate (DCR) at 12 weeks. Secondary endpoints included overall response rate, progression-free survival (PFS), overall survival (OS) and adverse events...
March 12, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29435905/neuroendocrine-carcinoma-of-gallbladder-a-step-beyond-palliative-therapy-experience-of-25-cases
#4
Amol Vijay Kanetkar, Shraddha Patkar, Krunal Harischandra Khobragade, Vikas Ostwal, Anant Ramaswamy, Mahesh Goel
PURPOSE: Published literature on gall bladder neuroendocrine tumors (GB NETs) is limited with none reporting the role of multimodal therapy. METHODS: Patients with histologically confirmed GB NETs treated at Tata Memorial Hospital, Mumbai, from January 2010 to June 2017 were analyzed. Staging was done by contrast-enhanced computed tomography (CECT) of abdomen and chest or a positron emission topography (PET) scan. Tumor marker (CA19-9) was measured. WHO-2017 guideline was used to classify GB NETs...
February 13, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29394711/-a-case-report-of-long-term-survival-after-excision-for-needle-tract-implantation-of-biopsy-and-hepatectomy-for-cholangiocarcinoma-with-gall-bladder-hemorrhage
#5
Kotaro Miyazawa, Shigeru Yoshioka, Masayuki Shiobara, Kazuo Wakatsuki, Syuka Arai, Kosuke Suda, Toshiaki Aida, Tetsutaro Miyoshi, Hirofumi Saito, Kazuto Yamazaki
A 77-year-old men with abdominal pain suffered from gall bladder hemorrhage and liver abcess was admitted for intensive care of severe acute cholangitis. He had hemobilia which was treated by the endoscopic retrograde bile duct drainage. After 2 months treatment with rest for purulent myelitis, he had neoplastic change of liver abcess diagnosed as intrahepatic bile duct cancer by percutaneous core needle biopsy. He underwent surgery as central bisegmentectomy and left the hospital at home 3 months later after rehabilitation for surgical site infection...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394646/-two-cases-of-non-occlusive-mesenteric-ischemia-that-developed-after-chemotherapy
#6
Takahiro Wada, Kenji Katsumata, Hiroshi Kuwahara, Takaaki Matsudo, Yusuke Murakoshi, Masatoshi Shigoka, Masanobu Enomoto, Tetsuo Ishizaki, Kazuhiko Kasuya, Akihiko Tsuchida
Non-occlusive mesenteric ischemia(NOMI)causes intestinal necrosis due to irreversible ischemia of the intestinal tract despite the absence of organic obstruction in the mesenteric blood vessels. The disease has extremely poor prognosis. We encountered 2 cases of NOMI hypothesized to have developed after chemotherapy; thus, we report these cases considering the available literature. Case 1: A7 9-year-old man. The patient complained of abdominal pain during the first week after introducing docetaxel for local recurrence of prostate cancer...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29393556/contrast-enhanced-ultrasound-complements-two-dimensional-ultrasonography-in-diagnosing-gallbladder-diseases-in-dogs
#7
Paolo Bargellini, Riccardo Orlandi, Chiara Paloni, Giuseppe Rubini, Paolo Fonti, Cecilia Righi, Mark E Peterson, Mark Rishniw, Cristiano Boiti
Gall-bladder diseases are common in dogs and two-dimensional ultrasonography is a current standard method for diagnosis and treatment planning. However, findings from this modality can be nonspecific. The aim of this retrospective, case series study was to describe conventional and contrast-enhanced ultrasound (using SonoVue® ) findings in a group of dogs with histologically confirmed gall bladder disease. A total of 65 dogs were included. Branchlike, heterogeneous, and homogeneous contrast enhancement of echogenic intraluminal mass-forming lesions was a contrast-enhanced ultrasound characteristic of polypoid lesions due to cystic mucosal hyperplasia of the gallbladder and/or tumor, which had different wash-in and washout characteristics...
February 2, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29376201/diagnostic-value-of-circulating-free-dna-integrity-and-global-methylation-status-in-gall-bladder-carcinoma
#8
Swati Kumari, Nuzhat Husain, Akash Agarwal, Azfar Neyaz, Sameer Gupta, Arun Chaturvedi, Mohtashim Lohani, Abhinav Arun Sonkar
The current study investigates the role of circulating free DNA (cfDNA) as a liquid biopsy in diagnosis gall bladder carcinoma (GBC) utilizing levels of long DNA fragments (ALU247) derived from tumor necrosis, short apoptotic fragments (ALU115) denoting total cfDNA and cfDNA integrity denoting ratio of ALU247 and ALU115. The global methylation status of cfDNA was also estimated with the hypothesis that these parameters provide a diagnostic distinction between cancer and non-cancer subjects, with higher or altered values favoring presence of malignancy...
January 28, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29363152/plasma-levels-of-innate-immune-mediators-are-associated-with-liver-fibrosis-in-low-parasite-burden-schistosoma-mansoni-infected-individuals
#9
Jailza Lima Rodrigues Oliveira, Mauro Martins Teixeira, José Roberto Lambertucci, Carlos Maurício de Figueiredo Antunes, Mariângela Carneiro, Deborah Negrão-Corrêa
In the murine model, it was demonstrated that pro-inflammatory cytokines and chemokines are essential to the formation and modulation of Schistosoma-induced granulomatous inflammation. However, the relationship of these immune mediators and disease severity is hard to be established in naturally infected individuals. The current study evaluates the association between plasma concentrations of MIF, sTNF-R1, CCL3, CCL7 and CCL24 and schistosomiasis morbidity in Schistosoma mansoni-infected patients with a low parasite burden...
January 24, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29362846/roles-of-pyruvate-carboxylase-in-human-diseases-from-diabetes-to-cancers-and-infection
#10
REVIEW
Udom Lao-On, Paul V Attwood, Sarawut Jitrapakdee
Pyruvate carboxylase (PC), an anaplerotic enzyme, plays an essential role in various cellular metabolic pathways including gluconeogenesis, de novo fatty acid synthesis, amino acid synthesis, and glucose-induced insulin secretion. Deregulation of PC expression or activity has long been known to be associated with metabolic syndrome in several rodent models. Accumulating data in the past decade clearly showed that deregulation of PC expression is associated with type 2 diabetes in humans, while targeted inhibition of PC expression in a mouse model reduced adiposity and improved insulin sensitivity in diet-induced type 2 diabetes...
January 23, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29331004/cholecystectomy-for-gall-stones-in-26-months-old-child
#11
Junaid Zeb, Shawana Asad, Irfanud Din Khattak, Mubashir Hussain
Cholelithiasis is a major cause of morbidity worldwide. The incidence of gall stone in children in Pakistan has not been sufficiently studied and is increasingly being detected: the reason may be a true rise in the incidence or an improvement in diagnosis due to liberal use of diagnostic facilities and thus the increased opportunity to detect disease. A healthy 2 years and 2 months old male child presented to outpatient with history of recurrent attacks of pain abdomen and anorexia. Ultrasonography showed a 0...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29275793/analysis-of-evidence-based-autism-symptoms-enhancement-by-acupuncture
#12
REVIEW
Hassan M M Abo Almaali, Ameer Gelewkhan, Zena A A Mahdi
Autism is considered as a complex developmental disability that appears during the first two years of life. It is considered as a neurological disorder that affects brain function leading to impaired development in social interaction and communication skills. Some clinical trials demonstrated that certain acupuncture points play relatively significant role in improving both signs and symptoms of this disease. Owing to limited information available about acupuncture point's combination and protocols, the present study aimed to explore the most frequently used acupuncture points and their channels for children with autism...
December 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29247966/post-cholecystectomy-syndrome-need-to-redo-laparoscopic-completion-surgery-a-case-report
#13
Ali Zahedian, Sekineh Kamali Ahangar, Yasser Asghari
INTRODUCTION: Cholecystectomy is the standard treatment for symptomatic gallbladder stone disease. However, symptoms such as abdominal pain and dyspepsia may persist even after surgery, if the gallbladder is incompletely removed known as postcholecystectomy syndrome. CASE PRESENTATION: A 55-year-old man with a history of open cholecystectomy presented with a complaint of recurrent pain on his upper abdomen. Abdominal ultrasonography and magnetic resonance cholangiopancreatography revealed a cystic structure in the gallbladder fossa, with a filling defect at the midpoint of the cystic duct, suggesting a retained stone in the cystic duct and residual gallbladder...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29230485/-importance-of-functional-diagnostics-in-gastroenterology
#14
REVIEW
M Hollenbach, A Hoffmeister, J Rosendahl, J Mössner
In this review article important and frequently used investigation methods for gastrointestinal functional diagnostics are presented. Some other rarely used special investigations are also explained. The hydrogen breath test is simple to carry out, ubiquitously available and enables the detection of lactose, fructose and sorbitol malabsorption. Furthermore, by the application of glucose, the test can be carried out when there is a suspicion of abnormal intestinal bacterial colonization and using lactulose for measuring small intestinal transit time...
January 2018: Der Internist
https://www.readbyqxmd.com/read/29212771/establishment-of-a-surgical-bile-duct-injection-technique-giving-direct-access-to-the-bile-ducts-for-studies-of-the-murine-biliary-tree
#15
Natalie Lie Berntsen, Bjarte Fosby, Laura Valestrand, Corey Tan, Henrik M Reims, Elisabeth Schrumpf, Tom Hemming Karlsen, Pål-Dag Line, Espen Melum
Cholangiopathies are progressive disorders with largely unknown pathoetiology and limited treatment options. We aimed to develop a novel surgical technique with direct access to the bile ducts that would complement existing mouse models of cholestasis, biliary inflammation, and fibrosis and present a new route of administration for testing of potential treatment strategies. We developed a surgical technique to access the murine biliary tree by injection of different solvents through catheterization of the gall bladder with simultaneous clamping of the common bile duct...
March 1, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29197189/incidental-gallbladder-cancer-at-cholecystectomy
#16
Faik Tatli, Abdullah Ozgönül, Yusuf Yucel, Hüseyin Cahit Yalcin, Resit Ciftci, Mehmet Gümer, Firat Erkmen, Rabia Altuntas, Ali Uzunkoy
BACKGROUND: Gallbladder tumours rank fifth in the world among gastrointestinal system tumours. Coincidental gallbladder tumours are diagnosed during cholecystectomies, or by examining the cholecystectomy material. AIMS: In this study, we aimed to evaluate the incidence of gallbladder cancer among patients undergoing cholecystectomies due to gallbladder disease. STUDY DESIGN: Retrospective study METHODS: The files of 341 patients who had undergone routine cholecystectomy operations between January 2013 and March 2016 were reviewed, and their pathology results were recorded...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29179521/silibinin-an-old-drug-for-hematological-disorders
#17
REVIEW
Hai Zou, Xing-Xing Zhu, Guo-Bing Zhang, Yuan Ma, Yi Wu, Dong-Sheng Huang
Introduction: Silibinin (silybin), a non-toxic natural polyphenolic flavonoid, is the principal and the most biologically active component of silymarin. It is efficient in the treatment of acute and chronic liver disorders caused by toxins, drug, alcohol, hepatitis, and gall bladder disorders. Further, in our previous studies, we explored the anti-cancer efficacy in common cancers, such as lung, prostatic, colon, breast, bladder, as well as, hepatocellular carcinoma. Interestingly, silibinin is still not solely limited to the treatment of these diseases...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29122896/persistent-bacteraemia-caused-by-staphylococcus-aureus-in-the-gall-bladder
#18
Alexander Tin Han Yu, Tony Cun, Esther Benamu, Cybele Renault
Staphylococcus aureusbacteraemia (SAB) remains a complex disease with a high associated morbidity and mortality, especially when it is able to establish an occult nidus safe from antimicrobial eradication. Without rapid identification and intervention, the nidus can cause persistent relapse of disease, morbidity and mortality. Having a high clinical suspicion for the foci of occult S. aureus is important, and awareness of potential sites of infection is critical and can be life-saving.We present a unique case of a 65-year-old man with end-stage renal disease receiving haemodialysis who developed septic shock from SAB...
November 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29121415/efficacy-and-safety-of-trametinib-in-japanese-patients-with-advanced-biliary-tract-cancers-refractory-to-gemcitabine
#19
MULTICENTER STUDY
Masafumi Ikeda, Tatsuya Ioka, Akira Fukutomi, Chigusa Morizane, Akiyoshi Kasuga, Hideaki Takahashi, Akiko Todaka, Takuji Okusaka, Caretha L Creasy, Shelby Gorman, Daniel J Felitsky, Mikiro Kobayashi, Fanghong Zhang, Junji Furuse
Gemcitabine-based therapy remains the mainstay of treatment for patients with biliary tract cancers (BTCs) with no second-line treatment(s) established yet. Aberrant activation of the MAPK pathway in patients with BTC indicates its importance in BTC. Trametinib is a potent, highly selective, allosteric non-competitive inhibitor of MEK1/MEK2. In this phase IIa open-label, single-arm study, we investigated the efficacy and safety of trametinib in Japanese patients with advanced BTC refractory to gemcitabine-based therapy...
January 2018: Cancer Science
https://www.readbyqxmd.com/read/29062198/matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-as-a-reliable-proteomic-method-for-characterization-of-escherichia-coli-and-salmonella-isolates
#20
Waleed S Shell, Mahmoud Lotfy Sayed, Fatma Mohamed Gad Allah, Fatma Elzahraa Mohamed Gamal, Afaf Ahmed Khder, A A Samy, Abdel Hakam M Ali
AIM: Identification of pathogenic clinical bacterial isolates is mainly dependent on phenotypic and genotypic characteristics of the microorganisms. These conventional methods are costive, time-consuming, and need special skills and training. An alternative, mass spectral (proteomics) analysis method for identification of clinical bacterial isolates has been recognized as a rapid, reliable, and economical method for identification. This study was aimed to evaluate and compare the performance, sensitivity and reliability of traditional bacteriology, phenotypic methods and matrix-assisted laser desorption-ionization-time-of-flight mass spectrometry (MALDI-TOF MS) in the identification of clinical Escherichia coli and Salmonella isolates recovered from chickens...
September 2017: Veterinary World
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