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https://www.readbyqxmd.com/read/29675617/is-acute-pulmonary-embolism-more-severe-in-the-presence-of-obstructive-sleep-apnea-results-from-an-observational-cohort-study
#1
Dinah Konnerth, Florian Schwarz, Michael Probst, Martin Seidler, Tanja Wagner, Christian Faul, Wolfgang von Scheidt, Martin Schwaiblmair, Thomas M Berghaus
Obstructive sleep apnea (OSA) might influence disease severity in acute pulmonary embolism (PE). 253 survivors of acute PE were evaluated for sleep-disordered breathing by portable monitoring and nocturnal polysomnography. PE patients with an apnea-hypopnoea index (AHI) ≥ 15/h were significantly older (p < 0.001), had significantly impaired renal (p < 0.001) and left ventricular functions (p = 0.003), showed significantly elevated troponin I (p = 0.005) and D-dimer levels (p = 0...
April 19, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29672821/a-rapid-differential-effect-of-rosuvastatin-and-atorvastatin-on-high-sensitivity-cardiac-troponin-i-in-subjects-with-stable-cardiovascular-disease
#2
Mathijs C Bodde, Paul Welsh, Sandrin C Bergheanu, Willem M Lijfering, Bart Mertens, An-Ho Liem, Arnoud van der Laarse, Naveed Sattar, J Wouter Jukema
Serum troponin within the normal range is an emerging predictor of cardiovascular mortality. We aimed to determine how rapidly high-sensitivity troponin -I (hs-cTnI) levels are lowered by statin therapy in patients with stable cardiovascular disease. In the RADAR substudy, patients were randomized, to atorvastatin 20 mg/day (n = 39) or rosuvastatin 10 mg/day (n = 39) and up-titrated in 6 week intervals to 80 mg of atorvastatin or 40 mg of rosuvastatin. Hs-cTnI concentrations were measured at baseline and at 6 and 18 weeks of follow-up...
April 19, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29672379/postoperative-troponin-elevation-myocardial-injury-and-pulmonary-embolism
#3
Bruce McClure Biccard
No abstract text is available yet for this article.
May 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29671536/high-sensitivity-troponin-i-of-less-than-5-ng-per-l-has-negative-predictive-value-of-99-9-for-cardiac-death-at-one-year
#4
David Slawson
No abstract text is available yet for this article.
March 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29670700/discovery-of-tirasemtiv-the-first-direct-fast-skeletal-muscle-troponin-activator
#5
Scott E Collibee, Gustave Bergnes, Alexander Muci, William F Browne, Marc Garard, Aaron C Hinken, Alan J Russell, Ion Suehiro, James Hartman, Raja Kawas, Pu-Ping Lu, Kenneth H Lee, David Marquez, Matthew Tomlinson, Donghong Xu, Adam Kennedy, Darren Hwee, Julia Schaletzky, Kwan Leung, Fady I Malik, David J Morgans, Bradley P Morgan
The identification and optimization of the first activators of fast skeletal muscle are reported. Compound 1 was identified from high-throughput screening (HTS) and subsequently found to improve muscle function via interaction with the troponin complex. Optimization of 1 for potency, metabolic stability, and physical properties led to the discovery of tirasemtiv ( 25 ), which has been extensively characterized in clinical trials for the treatment of amyotrophic lateral sclerosis.
April 12, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29670333/upregulation-of-vascular-endothelial-growth-factor-receptor-1-contributes-to-sevoflurane-preconditioning-mediated-cardioprotection
#6
Bin Qian, Yang Yang, Yusheng Yao, Yanling Liao, Ying Lin
Purpose: Sevoflurane preconditioning (SPC) can provide myocardial protective effects similar to ischemic preconditioning. However, the exact mechanism of SPC remains unclear. Previous studies indicate that vascular endothelial growth factor receptor 1 (VEGFR-1) is involved in ischemic preconditioning-mediated cardioprotection. This study was designed to determine the significance of VEGFR-1 signaling in SPC-mediated cardioprotection. Materials and methods: Myocardial ischemia-reperfusion (I/R) rat model was established using the Langendorff isolated heart perfusion apparatus...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29669963/protective-effect-of-remote-ischemic-preconditioning-on-myocardial-damage-after-percutaneous-coronary-intervention-in-stable-angina-patients-with-complex-coronary-lesions-subanalysis-of-a-randomized-controlled-trial
#7
Kentaro Ejiri, Toru Miyoshi, Kunihisa Kohno, Makoto Nakahama, Masayuki Doi, Mitsuru Munemasa, Masaaki Murakami, Atsushi Takaishi, Kazufumi Nakamura, Hiroshi Ito
BACKGROUND: The effect of remote ischemic preconditioning (RIPC) on periprocedural myocardial damage (pMD) in patients undergoing percutaneous coronary intervention (PCI) is controversial. The aim of this study was to investigate the effect of RIPC or intravenous nicorandil on pMD following elective PCI in a subgroup of patients with complex coronary lesions from a multicenter randomized controlled trial.Methods and Results:Patients with stable angina who underwent elective PCI were assigned to 3 groups: control, upper-limb RIPC or intravenous nicorandil...
April 18, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29669813/monophosphorylation-of-cardiac-troponin-i-at-ser23-24-is-sufficient-to-regulate-cardiac-myofibrillar-ca-2-sensitivity-and-calpain-induced-proteolysis
#8
Abel Martin-Garrido, Brandon J Biesiadecki, Hussam E Salhi, Yasin Shaifta, Cristobal G Dos Remedios, Serife Ayuz-Guner, Wenxuan Cai, Ying Ge, Metin Avkiran, Jonathan C Kentish
The acceleration of myocardial relaxation produced by β-adrenoceptor stimulation is mediated in part by protein kinase A (PKA)-mediated phosphorylation of cardiac troponin-I (cTnI), which decreases myofibrillar Ca2+ sensitivity. Previous evidence suggests that phosphorylation of both Ser23 and Ser24 in cTnI is required for this Ca2+ desensitization. PKA-mediated phosphorylation also partially protects cTnI from proteolysis by calpain. Here we report that protein kinase D (PKD) phosphorylates only one serine of cTnI Ser23/24...
April 18, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29669424/impact-of-chronic-antiplatelet-therapy-on-infarct-size-and-bleeding-in-patients-with-acute-myocardial-infarction
#9
Jeness Campodonico, Nicola Cosentino, Valentina Milazzo, Mara Rubino, Monica De Metrio, Ivana Marana, Marco Moltrasio, Marco Grazi, Gianfranco Lauri, Alice Bonomi, Fabrizio Veglia, Elisa Chiorino, Emilio Assanelli, Antonio L Bartorelli, Giancarlo Marenzi
BACKGROUND: Patients hospitalized with acute myocardial infarction (AMI) are often on prior single antiplatelet therapy (SAPT) or a dual antiplatelet therapy (DAPT). Whether chronic SAPT or DAPT is beneficial or associated with an increased risk in AMI is still controversial. METHODS AND RESULTS: We prospectively enrolled 1718 consecutive patients with AMI (798 ST-segment elevation myocardial infarction and 920 non-ST-segment elevation myocardial infarction) who were divided according to their chronic APT (no APT, SAPT, or DAPT)...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29668531/correlation-between-extended-leukocyte-differential-count-and-coronary-artery-disease
#10
Si Chen, Shulan Zhang, Haixia Luan, Xiaoli Zeng, Yongzhe Li, Hui Yuan
BACKGROUND: Leukocyte count is closely associated with the risk of coronary artery disease (CAD). Levels of leukocyte subpopulations in CAD patients, however, remain largely unknown. METHODS: In the present study, we compared the distributions and counts of 16 leukocyte subpopulations between 40 CAD patients and 40 healthy controls using the CytoDiff flow cytometric system. RESULTS: Our results demonstrated significant increases in the frequencies and counts of all monocytes, immature granulocytes and B-lymphocytes in CAD patients, suggesting the levels of these leukocyte subpopulations may serve as potential biomarkers for diagnosis of CAD...
April 10, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29667902/myocardial-protection-following-del-nido-cardioplegia-in-pediatric-cardiac-surgery
#11
Debasish Panigrahi, Saibal Roychowdhury, Rahul Guhabiswas, Emmanuel Rupert, Mrinalendu Das, Pradeep Narayan
Background This study was designed to compare myocardial protection with del Nido cardioplegia and conventional blood cardioplegia in children undergoing cardiac surgery in Risk Adjustment for Congenital Heart Surgery categories 1 and 2. Methods Sixty patients were randomized into 2 groups receiving del Nido cardioplegia solution or conventional blood cardioplegia. Myocardial injury was assessed using biochemical markers (troponin I and creatine kinase-MB). Vasoactive-inotropic scores were calculated to compare inotropic requirements...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29666561/comparison-of-barricor%C3%A2-vs-lithium-heparin-tubes-for-selected-routine-biochemical-analytes-and-evaluation-of-post-centrifugation-stability
#12
Anne Marie Dupuy, Stéphanie Badiou, Delphine Daubin, Anne Sophie Bargnoux, Chloé Magnan, Kadda Klouche, Jean Paul Cristol
Introduction: Obtaining suitable results unaffected by pre- or postanalytical phases is pivotal for clinical chemistry service. We aimed comparison and stability of nine biochemical analytes after centrifugation using Barricor™ plasma tubes with mechanical separator vs standard Vacutainer® lithium heparin tubes. Materials and methods: We collected samples on six healthy volunteers and nine patients from intensive care units into 6 mL plastic Vacutainer® lithium heparin tubes and 5...
June 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29664430/-kounis-syndrome-a-paradoxal-non-st-elevation-myocardial-infarction-case-after-triamcinolone-treatment-for-dermatitis
#13
Mücahid Yılmaz, Hasan Korkmaz
Kounis syndrome is defined as the clinical development of acute coronary syndrome caused by the activation of inflammatory cells due to an allergy, hypersensitivity, anaphylaxis, or anaphylactic reaction. Corticosteroids that are used in the treatment of many inflammatory conditions may paradoxically cause allergic reactions and even anaphylaxis. This article is a description of the case of a 52-yearold female patient who had a non-ST elevation myocardial infarction after the administration of triamcinolone that was relieved with antihistaminic treatment...
April 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29664001/-protective-effect-of-mild-hypothermia-at-different-starting-times-on-organ-function-in-patient-with-exertional-heat-stroke
#14
Qinghua Li, Rongqing Sun, Hongdi Lyu, Dexin Shen, Qing Hu, Haiwei Wang, Nannan Wang, Jin Yan, Jing Wang
OBJECTIVE: To investigate the protective effect of mild hypothermia at different starting times on the physiological functions of the viscera of exertional heat stroke (EHS). METHODS: A prospective randomized controlled trial was conducted. EHS patients admitted to intensive care unit of the 159th Hospital of People's Liberation Army and the First Affiliated Hospital of Zhengzhou University from June 2015 to June 2017 were enrolled. The patients were divided into 2, 4, 6 hours start hypothermia treatment groups according to the random number table method, the mild hypothermia was initiated at 2, 4 and 6 hours after the disease onset respectively, and the methods were the same in each group...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663996/-establishment-and-evaluation-of-mouse-models-of-septic-myocardial-injury
#15
Liya Hu, Peijun Li, Chao Chang, Shan Liu, Yanqiu Song, Fumei Zhao, Ting Liu
OBJECTIVE: Mouse models of sepsis-induced myocardial injury by intraperitoneal injection of lipopolysaccharide (LPS) was established in order to provide a reliable method for the research of pathogenesis of sepsis-induced myocardial injury. METHODS: According to the method of random number table, a total of 150 male C57BL/6 mice were divided into five groups: NC group, sham group, and LPS 10, 12, 15 mg/kg groups, with 30 in each group. Septic myocardial injury was induced by intraperitoneal injection LPS in mice; sham group was injected with equal 0...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663995/-risk-factors-of-atrial-fibrillation-in-critical-ill-patients
#16
Jianyu Fu, Hongying Bi, Yunsong Xia, Hui Fang, Xu Liu, Yan Tang, Difen Wang
OBJECTIVE: To observe the clinical features of atrial fibrillation (AF) patients, and to explore the correlation between the routine detection index and the new-onset AF and to find out risk factors for new AF in critically ill patients. METHODS: A prospective observational study was conducted. The patients with AF admitted to intensive care unit (ICU) of the Affiliated Hospital of Guizhou Medical University from March 2016 to June 2017 were enrolled. The patients were divided into new-onset AF group and past-existed AF group according to their past history of AF (including persistent AF, paroxysmal AF or permanent AF)...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663994/-predictive-value-of-early-phrase-echocardiography-and-cardiac-biological-markers-in-patients-with-severe-sepsis-a-five-year-single-center-retrospective-study
#17
Xuefeng Zang, Wei Chen, Bo Sheng, Lei Zhao, Xuyun Gu, Jie Zhen, Ping Liu
OBJECTIVE: To assess the predictive value of early phrase echocardiography and cardiac biomarkers in patients with severe sepsis. METHODS: A retrospective analysis of severe septic patients (patients with acute coronary syndrome and end stage renal disease were excluded) in department of intensive care unit of Capital Medical University Affiliated Beijing Shijitan Hospital from January 2013 to December 2017 was conducted. The acute physiology and chronic health evaluation II (APACHE II) score, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), myoglobin (MYO), creatine kinase (CK), MB isoenzyme of creatine kinase (CK-MB) within 6 hours after admission, and bedside echocardiography indexes [left ventricular ejection fraction (LVEF), the ratio of the peak blood flow velocity in the early stage of the mitral valve and the peak blood flow rate of the mitral valve (E/A ratio)] within 6 hours after diagnosis were recorded...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663841/novel-heart-failure-biomarkers-why-do-we-fail-to-exploit-their-potential
#18
Arnold Piek, Weijie Du, Rudolf A de Boer, Herman H W Silljé
Plasma biomarkers are useful tools in the diagnosis and prognosis of heart failure (HF). In the last decade, numerous studies have aimed to identify novel HF biomarkers that would provide superior and/or additional diagnostic, prognostic, or stratification utility. Although numerous biomarkers have been identified, their implementation in clinical practice has so far remained largely unsuccessful. Whereas cardiac-specific biomarkers, including natriuretic peptides (ANP and BNP) and high sensitivity troponins (hsTn), are widely used in clinical practice, other biomarkers have not yet proven their utility...
April 17, 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29663176/serum-magnesium-and-risk-of-incident-heart-failure-in-older-men-the-british-regional-heart-study
#19
Sasiwarang Goya Wannamethee, Olia Papacosta, Lucy Lennon, Peter H Whincup
To examine the association between serum magnesium and incident heart failure (HF) in older men and investigate potential pathways including cardiac function, inflammation and lung function. Prospective study of 3523 men aged 60-79 years with no prevalent HF or myocardial infarction followed up for a mean period of 15 years, during which 268 incident HF cases were ascertained. Serum magnesium was inversely associated with many CVD risk factors including prevalent atrial fibrillation, lung function (FEV1 ) and markers of inflammation (IL-6), endothelial dysfunction (vWF) and cardiac dysfunction [NT-proBNP and cardiac troponin T (cTnT)]...
April 17, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29663169/troponin-i2-as-a-specific-biomarker-for-prediction-of-peritoneal-metastasis-in-gastric-cancer
#20
Koichi Sawaki, Mitsuro Kanda, Takashi Miwa, Shinichi Umeda, Haruyoshi Tanaka, Chie Tanaka, Daisuke Kobayashi, Masaya Suenaga, Norifumi Hattori, Masamichi Hayashi, Suguru Yamada, Goro Nakayama, Michitaka Fujiwara, Yasuhiro Kodera
BACKGROUND: Although peritoneal metastasis is a serious concern in patients with gastric cancer, no acceptable and specific biomarker is available. We aimed to identify a candidate biomarker to predict peritoneal metastasis of gastric cancer. METHODS: Metastatic pathway-specific transcriptome analysis was conducted by comparison of patient groups with no recurrence and with peritoneal, hepatic, and nodal recurrence. Fifteen cell lines and 262 pairs of surgically resected gastric tissues were subjected to messenger RNA (mRNA) expression analysis...
April 16, 2018: Annals of Surgical Oncology
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