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https://www.readbyqxmd.com/read/28227690/muscle-fiber-excitation-system
#1
Bertram N Ezenwa, Thomas Kernozek, Bertram N Ezenwa, Thomas Kernozek, Thomas Kernozek, Bertram N Ezenwa
Persons unable to exercise due to old age, immobility or medical condition may develop low bone density, decline in muscle contraction, blood pooling or clot. Due to musculoskeletal fragility caution is required in bone and muscle strengthening. Similarly, caution is required to use anticoagulant drug to prevent blood clot due to side effect, and compression devices are not as effective as drug. This paper presents a transcutaneous muscle fiber excitation system adaptable for use in seated, walking or lying position...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227326/detection-of-binaural-interaction-in-free-field-evoked-auditory-brainstem-responses-by-time-scale-representations
#2
Erik Schebsdat, Horst Hessel, Harald Seidler, Daniel J Strauss, Erik Schebsdat, Horst Hessel, Harald Seidler, Daniel J Strauss, Horst Hessel, Erik Schebsdat, Harald Seidler, Daniel J Strauss
The so called β-wave of the binaural interaction component (BIC) in auditory brainstem responses (ABR) has been shown to be an objective measure for binaural interaction (BI). This component is the arithmetical difference between the sum of the monaurally evoked ABRs and the binaurally evoked ABR. Unfortunately, these neural responses are known to be very fragile and as a result the calculated BIC. An additional issue is, that the findings of this measurement are predominantly needed in people with hearing loss who may use hearing devices like hearing aids (HA) or cochlear implants (CI), thus they are not able to use headphones (like in conventional ABR measurements) during the detection of possible BI...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226890/stability-of-the-microdroplets-for-portable-biosensor
#3
Yusuke Izawa, Toshihisa Osaki, Koki Kamiya, Satoshi Fujii, Norihisa Miki, Shoji Takeuchi, Yusuke Izawa, Toshihisa Osaki, Koki Kamiya, Satoshi Fujii, Norihisa Miki, Shoji Takeuchi, Koki Kamiya, Satoshi Fujii, Norihisa Miki, Shoji Takeuchi, Yusuke Izawa, Toshihisa Osaki
This paper highlights the behavior of microdroplets used for portable biosensors. Microdroplets have been applied for various Lab-on-a-chip applications, in which portability/wearable is becoming a trend word. However, the resonance (sloshing phenomena) of the microdroplets could be an issue. For example, bilayer lipid membrane, fragile characteristics due to its thickness of 5 nm, easily ruptures by jiggling. We therefore prepared various dimensions of droplets by changing the well shape, and examined the resulting waves depending on the vibration frequency between 20 and 100 Hz, including daily life frequencies...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226747/automatic-detection-of-neovascularization-on-optic-disk-region-with-feature-extraction-and-support-vector-machine
#4
Shuang Yu, Di Xiao, Yogesan Kanagasingam, Shuang Yu, Di Xiao, Yogesan Kanagasingam, Di Xiao, Yogesan Kanagasingam, Shuang Yu
Neovascularization (NV) is a definitive indicator for the onset of Proliferative Diabetic Retinopathy (PDR). The new vessels are fragile and prone to bleed, leading to high risk of sudden vision loss. Automatic detection of NV is an important task in automatic Diabetic Retinopathy (DR) screening as a consequence of the unmet requirement between the growing number of DR patients and limited number of ophthalmologists. This paper focuses on the computer aided detection of neovascularization in the optic disk region...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226719/a-new-hybrid-watermarking-algorithm-for-mri-medical-images-using-dwt-and-hash-functions
#5
F Taher, A Kunhu, H AlAhmad, F Taher, A Kunhu, H AlAhmad, H AlAhmad, A Kunhu, F Taher
This paper deals with a blind hybrid digital watermarking algorithm for the copyright protection and authentication of magnetic resonance tomography images. Medical image watermarking requires extreme care when embedding watermark information in the medical images, to protect the image quality from being violated and to avoid the wrong diagnosis that might occur. The proposed algorithm contains robust watermark for the ownership protection and fragile watermarks for checking the authenticity. In the proposed algorithm, the medical image is divided into two regions, called the Region of Interest and Region of Non-Interest using histogram technique and the watermarks are embedded in both wavelet domain and spatial domain in the Region of Non-Interest Area...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226675/bone-texture-characterization-for-osteoporosis-diagnosis-using-digital-radiography
#6
Keni Zheng, Sokratis Makrogiannis, Keni Zheng, Sokratis Makrogiannis, Sokratis Makrogiannis, Keni Zheng
We introduce texture classification techniques to effectively diagnose osteoporosis in bone radiography data. Osteoporosis is an age-related systemic bone skeletal disorder characterized by low bone mass and bone structure deterioriation that results in increased bone fragility and higher fracture risk. Therefore, early diagnosis can effectively predict fracture risk and prevent the disease. Automated diagnosis from digital radiographs is very challenging since the scans of healthy and osteoporotic subjects show little or no visual differences, and their density histograms mostly overlap...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223919/commentary-depletion-of-the-fragile-x-mental-retardation-protein-in-embryonic-stem-cells-alters-the-kinetics-of-neurogenesis
#7
COMMENT
Cara J Westmark
No abstract text is available yet for this article.
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28223372/perspectives-of-low-socioeconomic-status-mothers-of-premature-infants
#8
Elizabeth Enlow, Laura J Faherty, Sara Wallace-Keeshen, Ashley E Martin, Judy A Shea, Scott A Lorch
BACKGROUND AND OBJECTIVES: Transitioning premature infants from the NICU to home is a high-risk period with potential for compromised care. Parental stress is high, and families of low socioeconomic status may face additional challenges. Home visiting programs have been used to help this transition, with mixed success. We sought to understand the experiences of at-risk families during this transition to inform interventions. METHODS: Mothers of infants born at <35 weeks' gestation, meeting low socioeconomic status criteria, were interviewed by telephone 30 days after discharge to assess caregiver experiences of discharge and perceptions of home visitors (HVs)...
February 21, 2017: Pediatrics
https://www.readbyqxmd.com/read/28223318/a-drosophila-model-of-fragile-x-syndrome-exhibits-defects-in-phagocytosis-by-innate-immune-cells
#9
Reed M O'Connor, Elizabeth F Stone, Charlotte R Wayne, Emily V Marcinkevicius, Matt Ulgherait, Rebecca Delventhal, Meghan M Pantalia, Vanessa M Hill, Clarice G Zhou, Sophie McAllister, Anna Chen, Jennifer S Ziegenfuss, Wesley B Grueber, Julie C Canman, Mimi M Shirasu-Hiza
Fragile X syndrome, the most common known monogenic cause of autism, results from the loss of FMR1, a conserved, ubiquitously expressed RNA-binding protein. Recent evidence suggests that Fragile X syndrome and other types of autism are associated with immune system defects. We found that Drosophila melanogaster Fmr1 mutants exhibit increased sensitivity to bacterial infection and decreased phagocytosis of bacteria by systemic immune cells. Using tissue-specific RNAi-mediated knockdown, we showed that Fmr1 plays a cell-autonomous role in the phagocytosis of bacteria...
February 21, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28222716/assessing-the-feasibility-of-introducing-health-insurance-in-afghanistan-a-qualitative-stakeholder-analysis
#10
Wu Zeng, Christine Kim, Lauren Archer, Omarzaman Sayedi, Mohammad Yousuf Jabarkhil, Kathleen Sears
BACKGROUND: In the last decade, the health status of Afghans has improved drastically. However, the health financing system in Afghanistan remains fragile due to high out-of-pocket spending and reliance on donor funding. To address the country's health financing challenges, the Ministry of Public Health investigated health insurance as a mechanism to mobilize resources for health. This paper presents stakeholders' opinions on seven preconditions of implementing this approach, as their understanding and buy-in to such an approach will determine its success...
February 22, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28222427/impact-of-fmr1-pre-mutation-status-on-blastocyst-development-in-patients-undergoing-pre-implantation-genetic-diagnosis
#11
Anne P Hutchinson, Nigel Pereira, Debra P Lilienthal, Siobhán Coveney, Jovana P Lekovich, Rony T Elias, Zev Rosenwaks
BACKGROUND/AIMS: The study aimed to investigate the impact of fragile X mental retardation 1 (FMR1) pre-mutation status on blastocyst development in patients undergoing pre-implantation genetic diagnosis (PGD). METHODS: Case-control study of patients <40 years undergoing PGD at blastocyst stage for FMR1 pre-mutation status. Age-matched patients undergoing PGD for other single gene disorders were considered controls. Blastocyst development, calculated per metaphase II (MII) oocyte retrieved and per 2 pronuclear (2PN) embryos, was compared between the 2 groups...
February 22, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28220607/neurological-and-spinal-manifestations-of-the-ehlers-danlos-syndromes
#12
Fraser C Henderson, Claudiu Austin, Edward Benzel, Paolo Bolognese, Richard Ellenbogen, Clair A Francomano, Candace Ireton, Petra Klinge, Myles Koby, Donlin Long, Sunil Patel, Eric L Singman, Nicol C Voermans
The Ehlers-Danlos syndromes (EDS) are a heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin extensibility, and tissue fragility. This communication briefly reports upon the neurological manifestations that arise including the weakness of the ligaments of the craniocervical junction and spine, early disc degeneration, and the weakness of the epineurium and perineurium surrounding peripheral nerves. Entrapment, deformation, and biophysical deformative stresses exerted upon the nervous system may alter gene expression, neuronal function and phenotypic expression...
February 21, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28219953/function-of-the-arabidopsis-kinesin-4-fra1-requires-abundant-processive-motility
#13
Anindya Ganguly, Logan DeMott, Ram Dixit
Processivity is important for kinesins that mediate intracellular transport. Structure-function analyses of N-terminal kinesins have identified several non-motor regions that affect processivity in vitro However, whether these structural elements affect kinesin processivity and function in vivo is not known. Here, we used an Arabidopsis kinesin-4, called Fragile Fiber1 (FRA1), which is thought to mediate vesicle transport to test whether mutations that alter processivity in vitro behave similarly in vivo and whether processivity is important for FRA1's function...
February 20, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28219578/valved-conduit-attached-to-left-ventricular-outflow-tract-for-valve-detachment-in-beh%C3%A3-et-s-disease
#14
Liang-Wan Chen, Xi-Jie Wu, Hua Cao, Xiao-Fu Dai
Standard aortic valve replacement for aortic regurgitation caused by Behçet's disease is frequently complicated by postoperative recurrent prosthetic valve detachment. To prevent this, we have developed a modified Bentall procedure, in which the valved conduit is proximally attached to the left ventricular outflow tract instead of to the fragile annulus, based on the fact that the left ventricular outflow tract myocardium is rarely involved in Behçet's disease. This modified Bentall procedure was performed in 5 Behçet's disease patients with prosthetic valve detachment after primary aortic valve replacement, and satisfactory results were achieved...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28219577/method-of-hemorrhage-control-from-the-aorta-after-repair-of-a-dissected-aortic-aneurysm
#15
Joseph Galea, Alexander Manché
Patients with Marfan syndrome and presenting with acute aortic dissection have fragile aorta, causing bleeding problems in the anastomosis between the graft and the aorta. Hemostatic impairment following circulatory arrest and prolonged cardiopulmonary bypass contribute to these problems. We describe a technique to control persistent bleeding from the anastomosis in the aortopulmonary recess using two kissing inflated balloons at the tip of two Foley catheters to tamponade the bleeding sites.
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28219082/growth-of-expressive-syntax-in-children-with-fragile-x-syndrome
#16
Rouzana Komesidou, Nancy C Brady, Kandace Fleming, Amy Esplund, Steven F Warren
Purpose: This research explored syntactic growth in children with fragile X syndrome (FXS) over a 5-year period, and variability in growth in relation to autism symptoms, nonverbal cognition, maternal responsivity, and gender. Method: Language samples at 4 time points from 39 children with FXS, 31 boys and 8 girls, were analyzed using the Index of Productive Syntax (Scarborough, 1990) and mean length of utterance (Brown, 1973). The degree of autism symptoms was evaluated using the Childhood Autism Rating Scale (Schopler, Reichler, & Renner, 1988) at the first time point...
February 1, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28218824/decreased-home-cage-movement-and-oromotor-impairments-in-adult-fmr1-ko-mice
#17
Stephen J Bonasera, Tammy R Chaudoin, Evan H Goulding, Mateusz Mittek, Anna Dunaevsky
Fragile X syndrome (FXS) is a common inherited disorder that significantly impacts family and patient day-to-day living across the entire lifespan. The childhood and adolescent behavioral consequences of FXS are well-appreciated. However, there are significantly fewer studies (except those examining psychiatric comorbidities) assessing behavioral phenotypes seen in adults with FXS. Mice engineered with a genetic lesion of Fmr1 recapitulate important molecular and neuroanatomical characteristics of FXS, and provide a means to evaluate adult behavioral phenotypes associated with FXS...
February 20, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28218616/droplet-lasers-a-review-of-current-progress
#18
David McGloin
It is perhaps surprising that something as fragile as a microscopic droplet could possibly form a laser. In this article we will review some of the underpinning physics as to how this might be possible, and then examine the state of the art in the field. The technology to create and manipulate droplets will be examined, as will the different classes of droplet lasers. We will discuss the rapidly developing field of droplet biolasers and explore how droplet lasers could give rise to new bio and chemical sensing and analysis...
February 20, 2017: Reports on Progress in Physics
https://www.readbyqxmd.com/read/28218269/enhanced-expression-of-adcy1-underlies-aberrant-neuronal-signalling-and-behaviour-in-a-syndromic-autism-model
#19
Ferzin Sethna, Wei Feng, Qi Ding, Alfred J Robison, Yue Feng, Hongbing Wang
Fragile X syndrome (FXS), caused by the loss of functional FMRP, is a leading cause of autism. Neurons lacking FMRP show aberrant mRNA translation and intracellular signalling. Here, we identify that, in Fmr1 knockout neurons, type 1 adenylyl cyclase (Adcy1) mRNA translation is enhanced, leading to excessive production of ADCY1 protein and insensitivity to neuronal stimulation. Genetic reduction of Adcy1 normalizes the aberrant ERK1/2- and PI3K-mediated signalling, attenuates excessive protein synthesis and corrects dendritic spine abnormality in Fmr1 knockout mice...
February 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28216134/spatial-distribution-and-composition-of-aliphatic-hydrocarbons-polycyclic-aromatic-hydrocarbons-and-hopanes-in-superficial-sediments-of-the-coral-reefs-of-the-persian-gulf-iran
#20
Ranjbar Jafarabadi Ali, Riyahi Bakhtiari Alireza, Aliabadian Mansour, Shadmehri Toosi Amirhossein
This study is the first quantitative report on petroleum biomarkers from the coral reefs systems of the Persian Gulf. 120 reef surface sediment samples from ten fragile coral reef ecosystems were collected and analyzed for grain size, biogenic elements, elemental ratios, and petroleum biomarkers (n-alkanes, PAHs(1) and Hopanes) to assess the sources and early diagenesis of sedimentary organic matter. The mean grain size of the reef sediments ranged from 13.56 to 37.11% (Clay), 26.92 to 51.73% (Sand) and 35...
February 16, 2017: Environmental Pollution
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