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https://www.readbyqxmd.com/read/27911342/impulsive-and-compulsive-behaviors-in%C3%A2-parkinson-disease-the-norwegian-parkwest-study
#1
Aleksander H Erga, Guido Alves, Jan Petter Larsen, Ole Bj Rn Tysnes, Kenn Freddy Pedersen
BACKGROUND: Impulsive and compulsive behaviors (ICBs) are frequent in Parkinson's disease (PD), but data from population-based cohorts is lacking. OBJECTIVES: To determine the frequency and associated demographic, clinical, neuropsychiatric and cognitive features of ICBs in a population-based PD cohort. METHODS: This cross-sectional study included 125 patients with PD and 159 age- and gender-matched normal controls recruited from the Norwegian ParkWest study...
November 30, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27853964/brain-pathway-differences-between-parkinson-s-disease-patients-with-and-without-rem-sleep-behavior-disorder
#2
Mina Ansari, Farzaneh Rahmani, Mahsa Dolatshahi, Atefe Pooyan, Mohammad Hadi Aarabi
PURPOSE: REM (rapid eye movement) sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and is a usual symptom of the early stages of Parkinson's disease (PD). PD patients with RBD represent faster motor and cognitive dysfunction progression. However, there are limited studies on possible structural brain changes underpinning this disorder. METHODS: Diffusion magnetic resonance imaging (DMRI) was used to assess whether microstructural abnormalities in the brain of 23 RBD positive PD are detectable compared to 31 RBD negative PD...
November 16, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27852371/-correlation-analysis-of-serum-calcium-level-and-cognition-in-the-patients-with-parkinson-s-disease
#3
J Liu, X P Zhou, L Zhang, Q Zhang, C F Liu, W F Luo
Objective: To investigate the relation between cognition and serum calcium in the patients with Parkinson's disease (PD), analyze the related factors of cognition, and evaluate the correlation of serum calcium with specific cognitive domains. Methods: A total of 77 patients with Parkinson's disease who was hospitalized in the Second Affiliated Hospital of Soochow University, from Dce 2013 to May 2015 were subjected to the cognitive, motor and depression function assessment, and the fasting blood calcium samples were collected from the PD patients and 75 normal control subjects...
November 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27820864/parkinson-patients-initial-trust-in-avatars-theory-and-evidence
#4
Andrija Javor, Gerhard Ransmayr, Walter Struhal, René Riedl
Parkinson's disease (PD) is a neurodegenerative disease that affects the motor system and cognitive and behavioral functions. Due to these impairments, PD patients also have problems in using the computer. However, using computers and the Internet could help these patients to overcome social isolation and enhance information search. Specifically, avatars (defined as virtual representations of humans) are increasingly used in online environments to enhance human-computer interaction by simulating face-to-face interaction...
2016: PloS One
https://www.readbyqxmd.com/read/27761641/impulse-control-behaviors-and-subthalamic-deep-brain-stimulation-in-parkinson-disease
#5
Aristide Merola, Alberto Romagnolo, Laura Rizzi, Mario Giorgio Rizzone, Maurizio Zibetti, Michele Lanotte, George Mandybur, Andrew P Duker, Alberto J Espay, Leonardo Lopiano
To determine the clinical and demographic correlates of persistent, remitting, and new-onset impulse control behaviors (ICBs) before and after subthalamic deep brain stimulation (STN-DBS) in Parkinson's disease (PD). We compared the pre- and post-surgical prevalence of ICBs, classified as impulse control disorders (ICD), dopamine dysregulation syndrome (DDS), and punding in 150 consecutive PD STN-DBS-treated patients and determined the association with motor, cognitive, neuropsychological, and neuropsychiatric endpoints...
October 19, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27743701/cognitive-function-in-1736-participants-in-ninds-exploratory-trials-in-pd-long-term-study-1
#6
Anne-Marie A Wills, Jordan J Elm, Rong Ye, Kelvin L Chou, Sotirios A Parashos, Robert A Hauser, Ivan Bodis-Wollner, Vanessa K Hinson, Chadwick W Christine, Jay S Schneider
INTRODUCTION: Clinical cohort studies suggest that mild cognitive impairment (MCI) is common in early Parkinson's disease (PD). The objectives of this paper were to describe cognitive function in a large clinical trial of early treated PD patients at baseline and over time using two brief cognitive screening tests. METHODS: In total 1741 participants were enrolled in the NINDS Exploratory Trials in Parkinson's disease (NET-PD) Long-term Study-1 (LS-1). The Symbol Digit Modalities Test (SDMT) was collected annually...
October 8, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27704616/anatomical-and-functional-correlates-of-persistent-pain-in-parkinson-s-disease
#7
Andrea Polli, Luca Weis, Roberta Biundo, Michael Thacker, Andrea Turolla, Kostantinos Koutsikos, K Ray Chaudhuri, Angelo Antonini
BACKGROUND: The pathophysiology of pain in Parkinson's disease (PD) is still poorly understood, although it is conceivable that supraspinal mechanisms may be responsible for pain generation and maintenance. METHODS: We examined brain functional and anatomical changes associated with persistent pain in 40 PD patients, 20 with persistent pain and 20 without pain. We also examined 15 pain-free healthy participants of similar age, gender, and cognitive state as a control group...
October 5, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27689617/clinical-complexity-and-use-of%C3%A2-antipsychotics-and-restraints-in%C3%A2-long-term-care-residents-with%C3%A2-parkinson-s-disease
#8
George A Heckman, Alexander M Crizzle, Jonathen Chen, Tamara Pringsheim, Nathalie Jette, Marie-Jeanne Kergoat, Leslie Eckel, John P Hirdes
BACKGROUND: Patients with Parkinson's disease (PD) and/or Parkinsonism are affected by a complex burden of comorbidity. Many ultimately require institutional care, where they may be subject to the application of physical restraints or the prescription of antipsychotic medications, making them more vulnerable to adverse outcomes. OBJECTIVES: The objectives of this paper are to: 1) describe the clinical complexity of older institutionalized persons with PD; and 2) examine patterns and predictors of restraint use and prescription of antipsychotics in this population...
September 29, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27687251/fully-automated-structural-mri-of-the-brain-in-clinical-dementia-workup
#9
Karin Persson, Geir Selbæk, Anne Brækhus, Mona Beyer, Maria Barca, Knut Engedal
BACKGROUND: The dementia syndrome has been regarded a clinical diagnosis but the focus on supplemental biomarkers is increasing. An automatic magnetic resonance imaging (MRI) volumetry method, NeuroQuant® (NQ), has been developed for use in clinical settings. PURPOSE: To evaluate the clinical usefulness of NQ in distinguishing Alzheimer's disease dementia (AD) from non-dementia and non-AD dementia. MATERIAL AND METHODS: NQ was performed in 275 patients diagnosed according to the criteria of ICD-10 for AD, vascular dementia and Parkinson's disease dementia (PDD); the Winblad criteria for mild cognitive impairment; the Lund-Manchester criteria for frontotemporal dementia; and the revised consensus criteria for Lewy body dementia (LBD)...
September 28, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27686164/contribution-of-four-lifelong-factors-of-cognitive-reserve-on-late-cognition-in-normal-aging-and-parkinson-s-disease
#10
Maud Rouillard, Michel Audiffren, Cédric Albinet, Mohamed Ali Bahri, Gaëtan Garraux, Fabienne Collette
INTRODUCTION: Cognitive reserve (CR) was proposed to explain how individual differences in brain function help to cope with the effects of normal aging and neurodegenerative diseases. Education, professional solicitations, and engagement in leisure and physical activities across the lifetime are considered as major determinants of this reserve. METHOD: Using multiple linear regression analyses, we tested separately in healthy elderly and Parkinson's disease (PD) populations to what extent cognitive performance in several domains was explained by (a) any of these four environmental lifespan variables; (b) demographic and clinical variables (age, gender, depression score, and, for the PD group, duration of disease and dopaminergic drugs)...
August 12, 2016: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/27649015/-hospital-mortality-in-parkinson-s-disease-retrospective-analysis-in-a-portuguese-tertiary-centre
#11
Joana Martins, Adriana Rua, Nuno Vila Chã
INTRODUCTION: Parkinson's disease is associated with high hospital mortality. Male gender, late age at onset, higher disability and the coexistence of cognitive impairment or depression have been suggested to be risk factors of death. Pneumonia and cardiovascular diseases are the leading causes of death. OBJECTIVE: To characterize the mortality (causes of hospital admission and death) of Parkinson's disease patients in a tertiary hospital, as well as demographic and clinical characteristics...
May 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27646647/combined-diffusion-tensor-imaging-and-arterial-spin-labeling-as-markers-of-early-parkinson-s-disease
#12
Xiaobo Wei, Ronghua Yan, Zhaoyu Chen, Ruihui Weng, Xu Liu, Huimin Gao, Xiaofeng Xu, Zhuang Kang, Zhexing Liu, Yan Guo, Zhenhua Liu, Jan Petter Larsen, Jin Wang, Beisha Tang, Mark Hallett, Qing Wang
This study aimed to identify a PD-specific MRI pattern using combined diffusion tensor imaging (DTI) and arterial spin labeling (ASL) to discriminate patients with early PD from healthy subjects and evaluate disease status. Twenty-one early and 22 mid-late PD patients, and 22 healthy, age/gender-matched controls underwent 3-T MRI with apparent diffusion coefficient (ADC), fractional anisotropy (FA), fiber number (FN) and cerebral blood flow (CBF) measurements. We found that compared with healthy subjects, there was a profound reduction in FN passing through the SN in PD...
September 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27618849/clinical-presentation-of-anxiety-in-parkinson-s-disease-a-scoping-review
#13
Sara G Lutz, Jeffrey D Holmes, Emily A Ready, Mary E Jenkins, Andrew M Johnson
Up to 40% of all individuals with Parkinson's disease (PD) are estimated to experience anxiety that interferes with daily functioning. This article describes research regarding the presentation of anxiety in PD and the influence anxiety has on participation in this population. A scoping review identified 1,635 articles, of which 49 met the inclusion criteria. This review identified that anxiety in PD is often associated with a range of clinical correlates related to demographic and clinical characteristics (age, gender, disease stage, duration, progression), motor symptoms (tremor, bradykinesia, dystonia, freezing of gait, symptom severity), treatment-related complications (on/off fluctuations, on with dyskinesia, unpredictable off), and non-motor symptoms (sleep abnormalities, fatigue, cognitive impairment, depression)...
July 2016: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/27582502/decrease-of-delta-oscillatory-responses-in-cognitively-normal-parkinson-s-disease
#14
Derya Durusu Emek-Savaş, Gülin Özmüş, Bahar Güntekin, Berril Dönmez Çolakoğlu, Raif Çakmur, Erol Başar, Görsev G Yener
Parkinson's disease (PD) is a common progressive neurodegenerative disorder. This study aims to compare sensory-evoked oscillations (SEOs) and event-related oscillations (EROs) of visual modality in cognitively normal PD patients and healthy controls. Sixteen PD and 16 age-, gender-, and education-matched healthy controls participated in the study. A simple flashlight was used for SEO and a classical visual oddball paradigm was used for target ERO. Oscillatory responses in the delta frequency range (0.5-3.5 Hz) were examined...
August 31, 2016: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/27567844/paired-studies-comparing-clinical-profiles-of-lewy-body-dementia-with-alzheimer-s-and-parkinson-s-diseases
#15
Douglas W Scharre, Shu-Ing Chang, Haikady N Nagaraja, Ariane Park, Anahita Adeli, Punit Agrawal, Anne Kloos, Deb Kegelmeyer, Shannon Linder, Nora Fritz, Sandra K Kostyk, Maria Kataki
Limited data compares clinical profiles of Lewy Body Dementia (LBD) with Alzheimer's disease (AD) and Parkinson's disease (PD). Twenty-one mildly demented ambulatory LBD subjects were individually matched by MMSE score with 21 AD subjects and by UPDRS motor score with 21 PD subjects. Matched by age, gender, education, and race, pairs were compared using cognitive, functional, behavioral, and motor measures. LBD group performed worse than PD on axial motor, gait, and balance measures. AD had more amnesia and orientation impairments, but less executive and visuospatial deficits than LBD subjects...
October 4, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27472883/parkinsonism-differentiates-idiopathic-normal-pressure-hydrocephalus-from-its-mimics
#16
Gilles Allali, Valentina Garibotto, Frèdèric Assal
BACKGROUND: Parkinsonism is frequent in neurological conditions affecting gait and cognition, such as idiopathic normal pressure hydrocephalus (iNPH) and iNPH mimics, but its discriminating value between these two groups is still unidentified. OBJECTIVE: This study aims to compare the prevalence of parkinsonism between iNPH and iNPH mimics and its discriminating value. METHODS: Among 141 patients with suspicion of iNPH (75.7±7.1 years; 31...
July 27, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27401782/subtypes-of-mild-cognitive-impairment-in-patients-with-parkinson-s-disease-evidence-from-the-landscape-study
#17
Elke Kalbe, Sarah Petra Rehberg, Ines Heber, Martin Kronenbuerger, Jörg B Schulz, Alexander Storch, Katharina Linse, Christine Schneider, Susanne Gräber, Inga Liepelt-Scarfone, Daniela Berg, Judith Dams, Monika Balzer-Geldsetzer, Rüdiger Hilker, Carola Oberschmidt, Karsten Witt, Nele Schmidt, Brit Mollenhauer, Claudia Trenkwalder, Annika Spottke, Sandra Roeske, Hans-Ulrich Wittchen, Oliver Riedel, Richard Dodel
OBJECTIVE: Inconsistent results exist regarding the cognitive profile in patients with Parkinson's disease with mild cognitive impairment (PD-MCI). We aimed at providing data on this topic from a large cohort of patients with PD-MCI. METHODS: Sociodemographic, clinical and neuropsychological baseline data from patients with PD-MCI recruited in the multicentre, prospective, observational DEMPARK/LANDSCAPE study were analysed. RESULTS: 269 patients with PD-MCI (age 67...
October 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27366342/characteristics-of-nonmotor-symptoms-in-progressive-supranuclear-palsy
#18
Ruwei Ou, Wei Song, Qianqian Wei, Ke Chen, Bei Cao, Yanbing Hou, Bi Zhao, Huifang Shang
Objectives. To explore the clinical correlates of nonmotor symptoms (NMS) in progressive supranuclear palsy (PSP) and their differences from healthy controls and patients with Parkinson's disease (PD). Methods. Twenty-seven PSP patients, 27 age- and gender-matched healthy controls (HC), and 27 age- and gender-matched PD patients were included for this case-control study. NMS were assessed using the Nonmotor Symptoms Scale (NMSS, including 9 domains). Results. All PSP patients reported NMS. The frequency and severity of "sleep/fatigue," "mood/apathy," "attention/memory," "gastrointestinal," "sexual dysfunction," and "miscellaneous" domains in PSP group were significantly higher than those in HC group (P < 0...
2016: Parkinson's Disease
https://www.readbyqxmd.com/read/27339106/associations-between-fine-motor-performance-in-activities-of-daily-living-and-cognitive-ability-in-a-nondemented-sample-of-older-adults-implications-for-geriatric-physical-rehabilitation
#19
Elizabeth B Fauth, Sydney Y Schaefer, Steven H Zarit, Marie Ernsth-Bravell, Boo Johansson
OBJECTIVE: Fine motor ability (FMA) is essential in certain activities of daily living (ADL) and is considered mostly as a component of physical function. We hypothesize that cognitive ability explains significant variance in ADL-related FMA, above and beyond what is explained by physical ability (grip strength). METHOD: Origins of Variance in the Old Old Study (OCTO)-Twin participants (n = 218), aged 80+ (dementia, stroke, Parkinson's disease excluded) were assessed on depressive symptoms (Center for Epidemiologic Studies-Depression Scale [CES-D]), a cognitive battery, grip strength, and FMA...
June 22, 2016: Journal of Aging and Health
https://www.readbyqxmd.com/read/27334897/montreal-cognitive-assessment-moca-and-mini-mental-state-examination-mmse-performance-in-progressive-supranuclear-palsy-and-multiple-system-atrophy
#20
Eleonora Fiorenzato, Luca Weis, Cristian Falup-Pecurariu, Stefania Diaconu, Chiara Siri, Elisa Reali, Gianni Pezzoli, Patrizia Bisiacchi, Angelo Antonini, Roberta Biundo
To determine if Montreal Cognitive Assessment (MoCA) is more sensitive than the commonly used Mini-Mental State Examination (MMSE) in detecting cognitive abnormalities in patients with probable progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) compared with Parkinson's disease (PD). In this multicenter observational study, MMSE and MoCA were administered in a random order to 130 patients: 35 MSA, 30 PSP and 65 age, and education and gender matched-PD. We assessed between-group differences for MMSE, MoCA, and their subitems...
December 2016: Journal of Neural Transmission
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