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https://www.readbyqxmd.com/read/28516474/relationship-between-pain-and-motor-and-non-motor-symptoms-in-parkinson-s-disease
#1
G Defazio, A Antonini, M Tinazzi, A F Gigante, S Pietracupa, R Pellicciari, M Bloise, R Bacchin, A Marcante, G Fabbrini, A Berardelli
BACKGROUND AND PURPOSE: Although female gender, depressive symptoms and medical conditions predisposing to pain are more common in patients with Parkinson's disease (PD) with pain, no study has yet explored the relationship between pain and other non-motor symptoms (NMS). METHODS: A total of 321 consecutive patients with PD [190 men/131 women aged 68.3 (SD 9.2) years] attending four Italian movement disorder clinics were studied. Demographic/clinical data were obtained by a standardized interview and the NMS scale...
May 18, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28439757/when-is-higher-level-cognitive-control-needed-for-locomotor-tasks-among-patients-with-parkinson-s-disease
#2
Inbal Maidan, Hagar Bernad-Elazari, Nir Giladi, Jeffrey M Hausdorff, Anat Mirelman
Turning has been implicated as a complex task that requires both motor and cognitive resources. Accumulating evidence shows that patients with Parkinson's disease (PD) require more steps and more time to complete a turn, however, the role of the prefrontal cortex during turning is not clear. Forty nine patients with PD without freezing of gait (mean age 71.7 ± 1.0 years; 67% men, disease duration 9.7 ± 1.3 years) performed motor and cognitive tests. Prefrontal activation, specifically in Brodmann area 10 (BA10), during turning and usual walking was measured using functional near infrared spectroscopy (fNIRS)...
April 24, 2017: Brain Topography
https://www.readbyqxmd.com/read/28387438/the-cognitive-footprint-of-psychiatric-and-neurological-conditions-cross-sectional-study-in-the-uk-biobank-cohort
#3
B Cullen, D J Smith, I J Deary, J J Evans, J P Pell
OBJECTIVE: We aimed to quantify the prevalence of cognitive impairment in adults with a history of mood disorder, schizophrenia, multiple sclerosis or Parkinson's disease, within a large general population cohort. METHOD: Cross-sectional study using UK Biobank data (n = 502 642). Psychiatric and neurological exposure status was ascertained via self-reported diagnoses, hospital records and questionnaires. Impairment on reasoning, reaction time and memory tests was defined with reference to a single unexposed comparison group...
June 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28341039/cognitive-impairment-and-bdnf-serum-levels
#4
Joanna Siuda, Maja Patalong-Ogiewa, Weronika Żmuda, Magdalena Targosz-Gajniak, Ewa Niewiadomska, Iwona Matuszek, Halina Jędrzejowska-Szypułka, Monika Rudzińska-Bar
BACKGROUND/AIMS: To investigate the alterations of brain-derived neurotrophic factor (BNDF) serum levels in subjects with different intensity of cognitive impairment and different neurodegenerative processes. MATERIAL AND METHODS: Serum BDNF levels were analyzed by ELISA kit in 378 subjects: 134 Alzheimer's disease (AD) patients, 115 amnestic mild cognitive impairment (MCI) patients, and 129 controls divided into two groups: neurodegenerative control group (ND), consisting of 49 Parkinson's disease patients without any cognitive complaints, and cognitively normal control group (CN), consisting of 80 subjects without any neurological disorders...
January 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28334403/cognitive-estimation-in-non-demented-parkinson-s-disease
#5
Federica Scarpina, Alessandro Mauro, Guido E D'Aniello, Giovani Albani, Gianluca Castelnuovo, Erika Ambiel, Sarah E MacPherson
Objective: The Cognitive Estimation Test (CET) is widely used in clinical and research settings to assess the ability to produce reasonable estimates to items that individuals would not know that the exact answer (e.g., "How fast do race horses run?"). We examined the performance of non-demented Parkinson's disease (PD) patients on the CET, because previous studies reported heterogeneous results about possible cognitive estimation impairments in PD. We also examined whether PD patients improve their performance if given the chance to reconsider their initial CET responses...
March 10, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28276860/a-parsimonious-scoring-and-normative-calculator-for-the-parkinson-s-disease-mild-cognitive-impairment-battery
#6
Ondrej Bezdicek, Zdenek Sulc, Tomas Nikolai, Hana Stepankova, Miloslav Kopecek, Robert Jech, Evžen Růžička
OBJECTIVE: The aim of the present study was to provide a regression-based calculator that takes premorbid functioning into account to detect subtle cognitive decline, as is often present in pre-dementia states, especially mild cognitive impairment in Parkinson's disease (PD-MCI). METHOD: We used demographic adjustments based on sex, age, and education of 699 normative participants that fulfilled exclusion criteria for ascertaining the diagnostic accuracy of the Movement Disorders Society PD-MCI battery at Level II...
February 28, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28268523/differences-in-white-matter-microstructure-between-parkinson-s-disease-patients-with-and-without-rem-sleep-behavior-disorder
#7
Farzaneh Rahmani, Mina Ansari, Atefeh Pooyan, Mehdi M Mirbagheri, Mohammad Hadi Aarabi
REM sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and usually occurs during the early stages of Parkinson disease (PD). PD patients with RBD represent faster motor progression and cognitive dysfunction. We used diffusion imaging to assess which regions are involved in this phenomenon. In the current study, we computed Quantitative Anisotropic (QA), which is based on spin distribution function (SDF) that quantifies the density of diffusing water and is more sensitive to psychological differences between groups and also diffusion MRI connectometry to conduct group analysis between age and gender matched PD patients with and without RBD...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263252/flexed-truncal-posture-in-parkinson-disease-measurement-reliability-and-relationship-with-physical-and-cognitive-impairments-mobility-and-balance
#8
Aimi L Forsyth, Serene S Paul, Natalie E Allen, Catherine Sherrington, Victor S C Fung, Colleen G Canning
BACKGROUND AND PURPOSE: Flexed truncal posture is common in people with Parkinson disease (PD); however, little is known about the mechanisms responsible or its effect on physical performance. This cross-sectional study aimed to establish the reliability of a truncal posture measurement and explore relationships between PD impairments and truncal posture, as well as truncal posture and balance and mobility. METHODS: A total of 82 people with PD participated. Truncal posture was measured in standing as the distance between vertebra C7 and a wall...
April 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28242255/olfactory-dysfunction-and-dementia-in-newly-diagnosed-patients-with-parkinson-s-disease
#9
Magdalena Eriksson Domellöf, Karl-Fredrik Lundin, Mona Edström, Lars Forsgren
INTRODUCTION: Studies report that up to 90% of patients with idiopathic Parkinson's disease (PD) have olfactory dysfunction (hyposmia). Hyposmia has also been connected to cognitive impairment and dementia in PD, but no studies of newly diagnosed patients followed longer than three years exists. The present study investigates the prevalence of olfactory dysfunction at PD diagnosis, how it evolves over time and whether hyposmia increases the risk of dementia in Parkinson's disease. METHODS: Olfactory function was assessed with Brief Smell Identification Test (B-SIT) in 125 newly diagnosed patients with PD...
May 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28226697/differences-in-white-matter-microstructure-between-parkinson-s-disease-patients-with-and-without-rem-sleep-behavior-disorder
#10
Farzaneh Rahmani, Mina Ansari, Atefeh Pooyan, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Farzaneh Rahmani, Mina Ansari, Atefeh Pooyan, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Mehdi M Mirbagheri, Farzaneh Rahmani, Atefeh Pooyan, Mina Ansari, Mohammad Hadi Aarabi
REM sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and usually occurs during the early stages of Parkinson disease (PD). PD patients with RBD represent faster motor progression and cognitive dysfunction. We used diffusion imaging to assess which regions are involved in this phenomenon. In the current study, we computed Quantitative Anisotropic (QA), which is based on spin distribution function (SDF) that quantifies the density of diffusing water and is more sensitive to psychological differences between groups and also diffusion MRI connectometry to conduct group analysis between age and gender matched PD patients with and without RBD...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224328/the-parkinson-s-disease-cognitive-rating-scale-pd-crs-normative-values-from-268-healthy-italian-individuals
#11
Gabriella Santangelo, Giovanna Lagravinese, Valeria Battini, Carlo Chiorri, Mattia Siciliano, Giovanni Abbruzzese, Carmine Vitale, Paolo Barone
The Parkinson's Disease-Cognitive Rating Scale (PD-CRS) is a cognitive screening battery that includes subtests to assess cortical and subcortical functions. It is a valid screening tool for mild cognitive impairment (MCI) in Parkinson's disease (PD) and is recommended for diagnosing PD-MCI-Level I. Until now, no study has provided population-based norms for the Italian population. The aim of the present study was to collect normative values in a sample of Italian healthy subjects. Two hundred and sixty-eight (125 men) participants of different ages (age range 30-79 years) and educational levels (from primary school to university) underwent the PD-CRS...
February 21, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28131236/regional-volumetric-change-in-parkinson-s-disease-with-cognitive-decline
#12
Myrlene Gee, Juergen Dukart, Bogdan Draganski, W R Wayne Martin, Derek Emery, Richard Camicioli
BACKGROUND: Parkinson's disease (PD), characterized by motor dysfunction and cognitive decline, may demonstrate specific patterns of brain atrophy. Although cross-sectional magnetic resonance imaging (MRI) studies show correlation between regional brain volume loss and cognitive impairment, there is only scarce evidence from longitudinal studies validating the link between cognition and brain anatomy in PD. OBJECTIVE: To test the relationship between magnitude and spatial extent of atrophy in PD patients with progressive, significant cognitive decline and dementia (PDD)...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28096070/a-comparative-study-of-tower-of-london-scoring-systems-and-normative-data
#13
Jiri Michalec, Ondrej Bezdicek, Tomas Nikolai, Pavel Harsa, Robert Jech, Petr Silhan, Martin Hyza, Evzen Ruzicka, Tim Shallice
OBJECTIVE: Tower of London (ToL) is a planning ability task that includes multiple versions. The original ToL was developed by Shallice together with two scoring systems (ToL-SS). Another two ToL-SS were proposed by Anderson et al. and Krikorian et al. The purpose of this study is to provide normative data for four ToL-SS and explore the effects of demographic variables on ToL performance. Furthermore, we aimed to determine the discriminative validity of these ToL-SS in clinical samples...
January 17, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28032408/onset-and-evolution-of-anxiety-in-parkinson-s-disease
#14
K Zhu, J J van Hilten, J Marinus
BACKGROUND AND PURPOSE: Anxiety is common in Parkinson's disease (PD) and has a great influence on quality of life. However, little is known about risk factors for development of anxiety in PD. We investigated which factors were associated with longitudinal changes in severity of anxiety symptoms and development of future anxiety in patients who were not anxious at baseline. METHODS: Analyses were performed on data of the PROfiling PARKinson's disease (PROPARK) cohort, a 5-year hospital-based longitudinal cohort of over 400 patients with PD who have been examined annually...
February 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28031994/covariation-between-plasma-phosphate-and-daytime-cortisol-in-early-parkinson-s-disease
#15
Lena Håglin, Lennart Bäckman
BACKGROUND: Disturbed phosphate homeostasis in early Parkinson's disease (PD) may originate from a stress-related condition and nutritional status among other risk factors, age, and gender. METHODS: Risk of malnutrition using Mini-nutritional assessment (MNA score) and plasma levels of protein markers and daytime cortisol at the time of diagnosis in PD (n = 75) were compared with a control group (n = 24). Cognition was assessed using the Mini-Mental State Examination (MMSE score) and motor function using Unified Parkinson's Disease Rating Scale (UPDRS-part III scale)...
December 2016: Brain and Behavior
https://www.readbyqxmd.com/read/28017549/gender-effect-on-non-motor-symptoms-in-parkinson-s-disease-are-men-more-at-risk
#16
A Nicoletti, R Vasta, G Mostile, G Nicoletti, G Arabia, G Iliceto, P Lamberti, R Marconi, L Morgante, P Barone, A Quattrone, M Zappia
INTRODUCTION: Several gender differences have been reported in Parkinson's Disease (PD). We evaluated the burden of non-motor symptoms (NMS) in PD and the possible gender differences in their occurrence. METHODS: The FRAGAMP study is a large multicenter case-control study. PD patients and controls underwent a face-to-face interview and a neurological examination performed by trained neurologists. Presence of NMS was investigated using a standardized questionnaire; cognitive impairment and depression were assessed using the Mini Mental State Examination and the Hamilton Depression Rating Scale respectively...
February 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28005921/association-of-functional-impairments-and-co-morbid-conditions-with-driving-performance-among-cognitively-normal-older-adults
#17
David B Carr, Peggy P Barco, Ganesh M Babulal, Sarah H Stout, Anne M Johnson, Chengjie Xiong, John C Morris, Catherine M Roe
OBJECTIVES: To examine the relationship between key functional impairments, co-morbid conditions and driving performance in a sample of cognitively normal older adults. DESIGN: Prospective observational study. SETTING: The Knight Alzheimer's Disease Research Center, Washington University at St. Louis. PARTICIPANTS: Individuals with normal cognition, 64.9 to 88.2 years old (N = 129), with a valid driver's license, who were currently driving at least once per week, and who had participated in longitudinal studies at the Knight Alzheimer's Disease Research Center...
2016: PloS One
https://www.readbyqxmd.com/read/27911342/impulsive-and-compulsive-behaviors-in%C3%A2-parkinson-s-disease-the-norwegian-parkwest-study
#18
Aleksander H Erga, Guido Alves, Jan Petter Larsen, Ole Bj Rn Tysnes, Kenn Freddy Pedersen
BACKGROUND: Impulsive and compulsive behaviors (ICBs) are frequent in Parkinson's disease (PD), but data from population-based cohorts is lacking. OBJECTIVES: To determine the frequency and associated demographic, clinical, neuropsychiatric and cognitive features of ICBs in a population-based PD cohort. METHODS: This cross-sectional study included 125 patients with PD and 159 age- and gender-matched normal controls recruited from the Norwegian ParkWest study...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27853964/brain-pathway-differences-between-parkinson-s-disease-patients-with-and-without-rem-sleep-behavior-disorder
#19
Mina Ansari, Farzaneh Rahmani, Mahsa Dolatshahi, Atefe Pooyan, Mohammad Hadi Aarabi
PURPOSE: REM (rapid eye movement) sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and is a usual symptom of the early stages of Parkinson's disease (PD). PD patients with RBD represent faster motor and cognitive dysfunction progression. However, there are limited studies on possible structural brain changes underpinning this disorder. METHODS: Diffusion magnetic resonance imaging (DMRI) was used to assess whether microstructural abnormalities in the brain of 23 RBD positive PD are detectable compared to 31 RBD negative PD...
November 16, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27852371/-correlation-analysis-of-serum-calcium-level-and-cognition-in-the-patients-with-parkinson-s-disease
#20
J Liu, X P Zhou, L Zhang, Q Zhang, C F Liu, W F Luo
Objective: To investigate the relation between cognition and serum calcium in the patients with Parkinson's disease (PD), analyze the related factors of cognition, and evaluate the correlation of serum calcium with specific cognitive domains. Methods: A total of 77 patients with Parkinson's disease who was hospitalized in the Second Affiliated Hospital of Soochow University, from Dce 2013 to May 2015 were subjected to the cognitive, motor and depression function assessment, and the fasting blood calcium samples were collected from the PD patients and 75 normal control subjects...
November 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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