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https://www.readbyqxmd.com/read/29126762/association-between-abnormal-nocturnal-blood-pressure-profile-and-dementia-in-parkinson-s-disease
#1
Ryota Tanaka, Yasushi Shimo, Kazuo Yamashiro, Takashi Ogawa, Kenya Nishioka, Genko Oyama, Atsushi Umemura, Nobutaka Hattori
BACKGROUND: Circadian blood pressure alterations are frequently observed in Parkinson's disease, but the association between these changes and dementia in the condition remains unclear. Here, we assess the relationship between abnormal nocturnal blood pressure profiles and dementia in Parkinson's disease. METHODS: We enrolled 137 patients with Parkinson's disease, who underwent 24 h ambulatory blood pressure monitoring, following cognitive and clinical assessment...
October 20, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29123499/gait-and-cognition-in-parkinson-s-disease-cognitive-impairment-is-inadequately-reflected-by-gait-performance-during-dual-task
#2
Heiko Gaßner, Franz Marxreiter, Simon Steib, Zacharias Kohl, Johannes C M Schlachetzki, Werner Adler, Bjoern M Eskofier, Klaus Pfeifer, Jürgen Winkler, Jochen Klucken
Introduction: Cognitive and gait deficits are common symptoms in Parkinson's disease (PD). Motor-cognitive dual tasks (DTs) are used to explore the interplay between gait and cognition. However, it is unclear if DT gait performance is indicative for cognitive impairment. Therefore, the aim of this study was to investigate if cognitive deficits are reflected by DT costs of spatiotemporal gait parameters. Methods: Cognitive function, single task (ST) and DT gait performance were investigated in 67 PD patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29118735/divergent-thinking-in-parkinsonism-a-case-control-study
#3
Margherita Canesi, Maria Luisa Rusconi, Emanuele Cereda, Alessandra Ranghetti, Viviana Cereda, Federica Moroni, Gianni Pezzoli
Background: Creativity is a multidimensional phenomenon and an important component of human capacities. This ability is characterized by the involvement of several cognitive functions particularly linked to the prefrontal cortex. We compared divergent thinking, a measure of creativity, in patients affected by progressive supranuclear palsy (PSP), other parkinsonian syndromes, and healthy controls (HCs). Methods: Creativity features were evaluated using the Abbreviated Torrance Test for Adults (ATTA)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29101795/impaired-frontal-lobe-functions-in-patients-with-parkinson-s-disease-and-psychosis
#4
Naveen Thota, Abhishek Lenka, Lija George, Shantala Hegde, Shyam Sundar Arumugham, Shweta Prasad, Albert Stezin, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal
INTRODUCTION: Patients with Parkinson's disease (PD) may develop several non-motor symptoms (NMS). Psychosis is one of the debilitating NMS of PD. The neurobiology of psychosis is not fully understood. This study aims to compare the frontal lobe functions of PD patients with and without psychosis using the Frontal Assessment Battery (FAB). METHODOLOGY: This study included 69 patients with PD; 34 with psychosis (PD-P) and 35 without psychosis (PD-NP). Mini Mental Status Examination (MMSE) was used to screen for cognitive impairment...
October 28, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29079677/can-we-predict-development-of-impulsive-compulsive-behaviours-in-parkinson-s-disease
#5
Lucia Ricciardi, Christian Lambert, Rosa De Micco, Francesca Morgante, Mark Edwards
OBJECTIVE: To determine clinical and structural imaging predictors of impulsive-compulsive behaviour (ICB) in de novo Parkinson's disease (PD). METHODS: From a cohort of 1116 subjects from the Parkinson's Progression Marker Initiative database, we created a subcohort of 42 de novo PD without ICB at baseline with available 3T MRI and who developed ICB during follow-up. PD-ICB were matched for age, gender and disease duration to 42 patients with PD without ICB over follow-up (PD-no-ICB) and 42 healthy controls (HCs)...
October 27, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28930751/dementia-predicting-cognitive-risk-score-and-its-correlation-with-cortical-thickness-in-parkinson-disease
#6
Byoung Seok Ye, Seun Jeon, Jee Hyun Ham, Jae Jung Lee, Jong Min Lee, Hye Sun Lee, Phil Hyu Lee, Young H Sohn
BACKGROUND: We developed a risk score system to predict risks of developing dementia in individual Parkinson disease (PD) patients using baseline neuropsychological tests. METHODS: A total of 216 nondemented PD patients underwent a baseline neuropsychological evaluation and were followed up for a mean of 2.7 (±1.1) years. Univariate Cox regression models controlled for age, gender, and education selected neuropsychological tests individually predicting dementia risk...
September 21, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28818561/the-rise-and-fall-of-impulse-control-behavior-disorders
#7
Giovanni Cossu, Roberta Rinaldi, Carlo Colosimo
INTRODUCTION: Impulse control disorders (ICDs) are psychiatric disorders characterized by the failure to resist an impulse or by the temptation to perform an act that is harmful to oneself or to others. METHODS: ICDs, including pathological gambling, hypersexuality, compulsive eating and shopping, can occur as a complication of Parkinson's disease (PD) together with other behavioral disorders, including dopamine dysregulation syndrome. This review is based on a literature search updated to May 2017, focusing on the epidemiology, clinical features, and therapeutic options of ICDs associated with PD...
August 1, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28807493/homocysteine-and-cognitive-function-in-parkinson-s-disease
#8
Nicole Licking, Charles Murchison, Brenna Cholerton, Cyrus P Zabetian, Shu-Ching Hu, Thomas J Montine, Amie L Peterson-Hiller, Kathryn A Chung, Karen Edwards, James B Leverenz, Joseph F Quinn
INTRODUCTION: Increased plasma homocysteine (HC) is a risk factor for dementia in the general population. Levodopa therapy causes increased plasma HC, but it remains unclear whether elevated plasma HC is associated with cognitive impairment in Parkinson's disease (PD). METHODS: The study population includes all participants in the Pacific Northwest Udall Center (PANUC) Clinical cohort at the time of the study, consisting of 294 individuals with PD who had a standardized neuropsychological assessment and plasma collection for HC measurement...
August 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28807457/identification-of-pseudobulbar-affect-symptoms-in-the-nursing-home-setting-development-and-assessment-of-a-screening-tool
#9
Carrie Allen, Barbara Zarowitz, Terrence O'Shea, Edward Peterson, Charles Yonan, Fanta Waterman
Pseudobulbar Affect (PBA) is a neurologic condition characterized by involuntary outbursts of crying and/or laughing disproportionate to patient mood or social context. Although an estimated 9% of nursing home residents have symptoms suggestive of PBA, they are not routinely screened. Our goal was to develop an electronic screening tool based upon characteristics common to nursing home residents with PBA identified through medical record data. Nursing home residents with PBA treated with dextromethorphan hydrobromide/quinidine sulfate (n = 140) were compared to age-, gender-, and dementia-diagnosis-matched controls without PBA or treatment (n = 140)...
August 11, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28791987/an-evaluation-of-neuropsychiatric-symptoms-in-parkinson-s-disease-patients
#10
S Oruc, G Gülseren, O Y Kusbecı, O Özbulut
OBJECTIVE: We aimed to examine neuropsychiatric symptoms of patients with early and advanced stage Parkinson's disease (PD). MATERIALS AND METHODS: The study was performed at Kocatepe University Neurology Department in Turkey, comprised 46 PD patients and 46 controls. Hoehn-Yahr (HY) scale was used to evaluate the clinical stages of PD and Unified Parkinson's Disease Rating Scale (UPDRS) was used to evaluate the severity of clinical signs. Cognitive functions were evaluated by Mini-Mental State Examination (MMSE) and neuropsychiatric findings were evaluated by Beck Depression Inventory (BDI), Scale for the Assessment of Positive Symptoms (SAPS), and Scale for the Assessment of Negative Symptoms (SANS)...
July 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28712000/predictors-of-weight-loss-in-early-treated-parkinson-s-disease-from-the-net-pd-ls-1-cohort
#11
Anne-Marie Wills, Ruosha Li, Adriana Pérez, Xuehan Ren, James Boyd
Weight loss is a common symptom of Parkinson's disease and is associated with impaired quality of life. Predictors of weight loss have not been studied in large clinical cohorts. We previously observed an association between change in body mass index and change in Unified Parkinson's Disease Rating Scale (UPDRS) motor and total scores. In this study, we performed a secondary analysis of longitudinal data (1-6 years) from 1619 participants in the NINDS Exploratory Trials in PD Long-term Study-1 (NET-PD LS1) to explore predictors of weight loss in a large prospective clinical trial cohort of early treated Parkinson's disease...
August 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28711192/predictors-of-anxiety-in-early-stage-parkinson-s-disease-results-from-the-first-two-years-of-a-prospective-cohort-study
#12
Sonja Rutten, Peter M van der Ven, Daniel Weintraub, Gregory M Pontone, Albert F G Leentjens, Henk W Berendse, Ysbrand D van der Werf, Odile A van den Heuvel
AIM: Anxiety has a negative impact on daily functioning and quality of life in patients with Parkinson's disease (PD). This study aims at assessing which sociodemographic and clinical characteristics predict the course of anxiety in early PD. METHODS: The participants of this two-year prospective cohort study were recently diagnosed PD patients not receiving psychiatric medications or dopamine replacement therapy at baseline. Assessments were performed annually after baseline...
October 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28673760/the-influence-of-sleep-disordered-breathing-in-rem-sleep-behavior-disorder
#13
Paulo Bugalho, Marcelo Mendonça, Raquel Barbosa, Manuel Salavisa
OBJECTIVES/BACKGROUND: Because both REM sleep behavior disorder (RBD) and Obstructive Sleep Apnea (OSA) can present with similar symptoms, it is important to understand the influence of OSA in the clinical manifestations of RBD and whether RBD modulates OSA severity. Our objectives were to compare: 1. the intensity of non-motor symptoms between RBD patients with (RBD-OSA) and without OSA (RBD-non-OSA), and 2. polysomnographic features between RBD-OSA and OSA without RBD (OSA-non-RBD) patients...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28670681/gender-differences-in-parkinson-s-disease-a-clinical-perspective
#14
REVIEW
D Georgiev, K Hamberg, M Hariz, L Forsgren, G-M Hariz
Available data indicate that there are gender differences in many features of Parkinson's disease (PD). Precise identification of the gender differences is important to tailor treatment, predict outcomes, and meet other individual and social needs in women and men with PD. The aim of this study was to review the available clinical data on gender differences in PD. Original articles and meta-analyses published between 1990 and 2016 systematically exploring gender differences in PD were reviewed. There is slight male preponderance in incidence and prevalence of PD...
July 2, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28662820/survival-in-parkinson-s-disease-in-relation-to-striatal-dopamine-transporter-binding
#15
Elina Mäkinen, Juho Joutsa, Tero Vahlberg, Valtteri Kaasinen
OBJECTIVE: To investigate whether dopamine transporter (DAT) binding, as measured with single photon emission computed tomography (SPECT), can be used to predict mortality in patients with Parkinson's disease (PD). METHODS: A total of 162 patients with PD and abnormal [I-123]FP-CIT SPECT were clinically followed for a median of 5.8 years. A multivariate Cox regression model was used to investigate survival with the independent predictors of age, gender, severity of motor impairment, levodopa-equivalent daily dose of medication, presence of cognitive defects, and putaminal specific binding ratio (SBR) of [I-123]FP-CIT...
September 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28647831/alterations-in-regional-homogeneity-of-resting-state-brain-activity-in-fatigue-of-parkinson-s-disease
#16
Junyi Li, Yongsheng Yuan, Min Wang, Jiejin Zhang, Li Zhang, Siming Jiang, Jian Ding, Kezhong Zhang
Fatigue is a common complaint in patients with Parkinson's disease (PD). However, the neural bases of fatigue in PD remain uncertain. In this cross-sectional study, our aim was to study the change of the local brain function in PD patients with fatigue. Among 49 patients with PD, 17 of them had fatigue and the remaining 32 patients without fatigue, and 25 age- and gender-matched healthy controls were enrolled. All subjects were evaluated with Fatigue Severity Scale (FSS) and had a resting-state functional magnetic resonance imaging (rs-fMRI) scan...
October 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28638722/associations-between-cognitive-impairment-and-motor-dysfunction-in-parkinson-s-disease
#17
Yi-Xuan Wang, Jue Zhao, Da-Ke Li, Fang Peng, Ying Wang, Ke Yang, Zhen-Yang Liu, Feng-Tao Liu, Jian-Jun Wu, Jian Wang
INTRODUCTION: Numerous studies have been carried out to explore the potential association between neurologic deficits and variable clinical manifestations of Parkinson's disease (PD). The aim of our study was to investigate the association between cognitive performance and motor dysfunction in Chinese patients with PD. METHODS: Data from 96 patients with PD were obtained from the Parkinson's disease patient cohort database of Huashan Hospital. All participants underwent a comprehensive neuropsychological evaluation to assess cognitive status, that included scoring on the Mini-mental state examination (MMSE), followed by more detailed cognitive assessment on five main cognitive domains (verbal memory, nonverbal memory, visuospatial function, language and attention/executive function)...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28621693/abnormalities-of-cortical-neural-synchronization-mechanisms-in-subjects-with-mild-cognitive-impairment-due-to-alzheimer-s-and-parkinson-s-diseases-an-eeg-study
#18
Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Cordone, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Maria Teresa Pascarelli, Flavio Nobili, Dario Arnaldi, Francesco Famà, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard Ransmayr, Georg Caravias, Heinrich Garn, Fabiola Sorpresi, Michela Pievani, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Erol Başar, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, Raffaella Franciotti, Giovanni B Frisoni, Laura Bonanni, Maria Francesca De Pandis
The aim of this retrospective and exploratory study was that the cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms might reveal different abnormalities in cortical neural synchronization in groups of patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) and Parkinson's disease (PDMCI) as compared to healthy subjects. Clinical and rsEEG data of 75 ADMCI, 75 PDMCI, and 75 cognitively normal elderly (Nold) subjects were available in an international archive...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28611616/differential-functional-connectivity-alterations-of-two-subdivisions-within-the-right-dlpfc-in-parkinson-s-disease
#19
Julian Caspers, Christian Mathys, Felix Hoffstaedter, Martin Südmeyer, Edna C Cieslik, Christian Rubbert, Christian J Hartmann, Claudia R Eickhoff, Kathrin Reetz, Christian Grefkes, Jochen Michely, Bernd Turowski, Alfons Schnitzler, Simon B Eickhoff
Patients suffering from Parkinson's disease (PD) often show impairments in executive function (EF) like decision-making and action control. The right dorsolateral prefrontal cortex (dlPFC) has been strongly implicated in EF in healthy subjects and has repeatedly been reported to show alterations related to EF impairment in PD. Recently, two key regions for cognitive action control have been identified within the right dlPFC by co-activation based parcellation. While the posterior region is engaged in rather basal EF like stimulus integration and working memory, the anterior region has a more abstract, supervisory function...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28596093/a-pilot-study-evaluating-the-association-between-physical-activity-and-cognition-among-individuals-with-parkinson-s-disease
#20
Paul D Loprinzi, Megan M Danzl, Elizabeth Ulanowski, Calli Paydo
BACKGROUND: Few studies have examined the association between daily physical activity and cognitive function among older adults with Parkinson's disease (PD). OBJECTIVE: Here we evaluate the association between accelerometer-assessed physical activity and cognition among older patients with PD. METHODS: Cognition assessed via the Montreal Cognitive Assessment (MoCA). Moderate-to-vigorous physical activity (MVPA) was assessed via accelerometry over a 1-2 week monitoring period...
June 1, 2017: Disability and Health Journal
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