keyword
MENU ▼
Read by QxMD icon Read
search

Lower Cholesterol

keyword
https://www.readbyqxmd.com/read/28749076/serum-and-gene-expression-levels-of-ct-1-il-6-and-tnf-%C3%AE-after-a-lifestyle-intervention-in-obese-children
#1
A Marti, L Morell-Azanza, T Rendo-Urteaga, S García-Calzón, A Ojeda-Rodríguez, N Martín-Calvo, M J Moreno-Aliaga, J A Martínez, M C Azcona-San Julián
BACKGROUND: Inflammation related molecules such as tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and cardiotrophin-1 (CT-1) are highly expressed in obese individuals and could partly explain some comorbidities associated to obesity. In obese children, lifestyle interventions are able to lower inflammation and reduce cardiovascular risk factors associated with obesity. The aim of the present work was to study changes in inflammation-related molecules serum and peripheral blood mononuclear cells (PBMC) transcript levels after a 10-week lifestyle intervention in obese children and asses their potential association with glucose metabolism...
July 27, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28746378/high-molecular-weight-adiponectin-homa-ir-ratio-as-a-biomarker-of-metabolic-syndrome-in-urban-multiethnic-brazilian-subjects
#2
Virgínia Genelhu de Abreu, Cyro José de Moraes Martins, Patricia Aguiar Cardoso de Oliveira, Emilio Antonio Francischetti
Metabolic syndrome (MetS) has an important epidemiological relevance due to its increasing prevalence and association with type 2 diabetes and cardiovascular disease. Insulin resistance is a core feature of the MetS. HOMA-IR is a robust clinical and epidemiological marker of MetS. Adiponectin is an adipokine with insulin-sensitizing and anti-inflammatory functions; its levels decrease as number of components of MetS increases. High-molecular weight adiponectin (HMWA) is the multimer responsible for the relationship of adiponectin with insulin sensitivity...
2017: PloS One
https://www.readbyqxmd.com/read/28745211/the-lipid-lowering-effects-and-associated-mechanisms-of-dietary-phytosterol-supplementation
#3
Jerad H Dumolt, Todd C Rideout
Phytosterols (PS) are plant-based structural analogous of mammalian cholesterol that have been shown to lower blood cholesterol concentrations by ~10%, although inter-individual response to PS supplementation due to subject-specific metabolic and genetic factors is evident. Recent work further suggests that PS may act as effective triglyceride (TG)-lowering agents with maximal TG reductions observed in hypertriglyceridemic subjects. Although PS have been demonstrated to interfere with cholesterol and perhaps TG absorption within the intestine, they also have the capacity to modulate the expression of lipid regulatory genes through liver X receptor (LXR) activation...
July 25, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28743108/high-density-lipoprotein-cholesterol-level-relates-to-working-memory-immediate-and-delayed-cued-recall-in-brazilian-older-adults-the-role-of-cognitive-reserve
#4
Andreas Ihle, Élvio R Gouveia, Bruna R Gouveia, Duarte L Freitas, Jefferson Jurema, Maria A Tinôco, Matthias Kliegel
AIMS: The present study set out to investigate the relation of the high-density lipoprotein cholesterol (HDL-C) level to cognitive performance and its interplay with key markers of cognitive reserve in a large sample of older adults. METHODS: We assessed tests of working memory, immediate and delayed cued recall in 701 older adults from Amazonas, Brazil. The HDL-C level was derived from fasting blood samples. In addition, we interviewed individuals on their education, past occupation, and cognitive leisure activity...
July 26, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28742767/sedentary-occupation-workers-who-meet-the-physical-activity-recommendations-have-a-reduced-risk-for-metabolic-syndrome-a-cross-sectional-study
#5
Rodrigo Alberto Vieira Browne, Luiz Fernando Farias-Junior, Yuri Alberto Freire, Daniel Schwade, Geovani de Araújo Dantas de Macêdo, Vilma Bayma Montenegro, Thiago Jambo Alves Lopes, Filipe Fernandes Oliveira Dantas, Eduardo Caldas Costa
OBJECTIVE: We tested the hypothesis that sedentary occupation workers who meet the physical activity recommendations present a lower risk for metabolic syndrome (MetS) than their nonactive counterparts. METHODS: A cross-sectional study involving 502 sedentary occupation workers. Physical activity level was self-reported. MetS was defined by International Diabetes Federation criteria. RESULTS: The active group showed lower odds for MetS [odds ratio (OR) 0...
July 24, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28742644/update-on-sglt2-inhibitors-new-data-released-at-the-american-diabetes-association
#6
Sara Lee
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are one of the newer classes of antiglycemic agents approved for the management of patients with type 2 diabetes mellitus. Due to their unique mechanism of action, SGLT2 inhibitors have shown to be beneficial beyond glucose control. The improvement in cardiovascular (CV) outcomes was first observed in the landmark EMPA-REG OUTCOMES study. Following these results, numerous CV outcome trials were designed to identify whether the beneficial CV and renal effects observed with empagliflozin are unique or a drug class effect...
September 2017: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/28741974/sarcopenia-and-physical-function-are-associated-with-inflammation-and-arteriosclerosis-in-community-dwelling-people-the-yakumo-study
#7
Tetsuro Hida, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Akio Muramoto, Kenyu Ito, Yoshimoto Ishikawa, Mikito Tsushima, Yoshihiro Nishida, Naoki Ishiguro, Yukiharu Hasegawa
OBJECTIVES: Sarcopenia reduces physical function, while chronic inflammation causes arteriosclerosis and decreases skeletal muscle. We conducted a cross-sectional study to elucidate the associations among sarcopenia, physical function, arteriosclerosis, and inflammation in community-dwelling people. METHODS: We recruited 335 participants in an annual health checkup. We diagnosed sarcopenia based on appendicular skeletal muscle mass index (aSMI) assessed by bioelectrical impedance analysis...
July 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28741856/relationship-between-vitamin-d-and-gestational-diabetes-in-overweight-or-obese-pregnant-women-may-be-mediated-by-adiponectin
#8
Aya Mousa, Sally K Abell, Soulmaz Shorakae, Cheryce L Harrison, Negar Naderpoor, Danielle Hiam, Alba Moreno-Asso, Nigel K Stepto, Helena J Teede, Barbora de Courten
SCOPE: Maternal vitamin D deficiency has been implicated in adverse pregnancy outcomes. However, the association between vitamin D and inflammation, particularly adipokines, remains unexplored in pregnancy. METHODS AND RESULTS: In 102 overweight or obese pregnant women at high-risk of gestational diabetes (GDM), we investigated relationships between maternal 25-hydroxyvitamin D (25(OH)D) concentrations at 12-15 weeks gestation (baseline) and serum lipids, inflammatory markers, novel adipokines (omentin-1, visfatin, high molecular weight (HMW)-adiponectin), and subsequent pregnancy outcomes (GDM, preeclampsia, preterm birth PTB])...
July 25, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28741806/serum-%C3%AE-glutamyltransferase-level-and-metabolic-syndrome-in-children-and-adolescents-korean-national-health-and-nutrition-examination-survey
#9
Jae-Min Park, Jee-Yon Lee, Duk-Chul Lee, Yong-Jae Lee
AIMS/INTRODUCTION: Serum γ-glutamyltransferase (GGT) is positively related to cardiometabolic diseases such as type 2 diabetes mellitus, hypertension, and metabolic syndrome (MetS) in adult populations. Our aim was to investigate whether serum GGT is independently associated with MetS and its components in a nationally representative sample of South Korean children and adolescents. MATERIALS AND METHODS: The study included data from 1,618 participants (867 boys, 751 girls) aged 10-18 years from the 2010-2011 Korean National Health and Nutrition Examination Survey...
July 25, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28741151/probiotic-characteristics-of-lactobacillus-curvatus-dn317-a-strain-isolated-from-chicken-ceca
#10
Mohamed Zommiti, Nathalie Connil, Jeannette Ben Hamida, Mounir Ferchichi
The probiotic characteristics of Lactobacillus curvatus DN317, a strain isolated from chicken ceca, were evaluated. This strain was selected for study from the isolated Lactobacillus strains because it has specific anti-microbial activity against Campylobacter jejuni ATCC 33560, Camp. jejuni NCTC 11168, Listeria monocytogenes ATCC 7644, and Bacillus subtilis ATCC 8633. Lact. curvatus DN317 showed an auto-aggregation percentage of 72% and presented the highest co-aggregation with Lact. monocytogenes ATCC 7644 (68%) compared to B...
July 24, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28740538/linarin-enriched-extract-attenuates-liver-injury-and-inflammation-induced-by-high-fat-high-cholesterol-diet-in-rats
#11
Zhen-Jie Zhuang, Chao-Wen Shan, Bo Li, Min-Xia Pang, Han Wang, Yan Luo, Yin-Lan Liu, Yu Song, Nan-Nan Wang, Su-Hong Chen, Jun-Ping Shi, Gui-Yuan Lv
The aim of this study was to explore the potential beneficial effects of linarin enriched Flos Chrysanthemi extract (Lin-extract) on nonalcoholic steatohepatitis (NASH) induced by high-fat high-cholesterol (HFHC) diet in rats. SD rats received normal diet, HFHC diet, or HFHC diet plus different doses of Lin-extract. The liver content of triglyceride and total cholesterol markedly increased in HFHC diet-fed model rats while middle and high dose of Lin-extract lowered liver cholesterol significantly. The expression of stearoyl-CoA desaturase (SCD1) was upregulated by HFHC diet and further elevated by high dose Lin-extract...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28740397/eligibility-for-alirocumab-or-evolocumab-treatment-in-1090-hypercholesterolemic-patients-referred-to-a-regional-cholesterol-treatment-center-with-ldl-cholesterol-%C3%A2-70-mg-dl-despite-maximal-tolerated-ldl-cholesterol-lowering-therapy
#12
Vybhav Jetty, Charles J Glueck, Kevin Lee, Naila Goldenberg, Marloe Prince, Ashwin Kumar, Michael Goldenberg, Ishan Anand, Ping Wang
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 inhibitors, Praluent (alirocumab [ALI]) and Repatha (evolocumab [EVO]) have been approved as adjuncts to the standard-of-care maximal-tolerated dose (MTD) of low-density lipoprotein cholesterol (LDLC)-lowering therapy (LLT), statin therapy, in heterozygous (HeFH) (ALI or EVO) or homozygous (EVO) familial hypercholesterolemia, or clinical atherosclerotic cardiovascular disease (CVD) where LDLC lowering is insufficient (both). Since LDLC lowering has been revolutionized by ALI and EVO, specialty pharmaceutical pricing models will be applied to a mass market...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28740256/influence-of-doxorubicin-on-model-cell-membrane-properties-insights-from-in-vitro-and-in-silico-studies
#13
Ana Catarina Alves, Aniket Magarkar, Miguel Horta, Jose L F C Lima, Alex Bunker, Cláudia Nunes, Salette Reis
Despite doxorubicin being commonly used in chemotherapy there still remain significant holes in our knowledge regarding its delivery efficacy and an observed resistance mechanism that is postulated to involve the cell membrane. One possible mechanism is the efflux by protein P-gp, which is found predominantly in cholesterol enriched domains. Thereby, a hypothesis for the vulnerability of doxorubicin to efflux through P-gp is its enhanced affinity for the ordered cholesterol rich regions of the plasma membrane...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28740125/apoe-genotype-influences-insulin-resistance-apolipoprotein-cii-and-ciii-according-to-plasma-fatty-acid-profile-in-the-metabolic-syndrome
#14
Rosalind Fallaize, Andrew L Carvalho-Wells, Audrey C Tierney, Carmen Marin, Beata Kieć-Wilk, Aldona Dembińska-Kieć, Christian A Drevon, Catherine DeFoort, José Lopez-Miranda, Ulf Risérus, Wim H Saris, Ellen E Blaak, Helen M Roche, Julie A Lovegrove
Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma FA, blood pressure, insulin sensitivity and lipid concentrations were determined at baseline and following a 12-week randomized, controlled, parallel, dietary FA intervention in 442 adults with MetS (LIPGENE study). FA-APOE gene interactions at baseline and following change in plasma FA were assessed using adjusted general linear models...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28739055/dietary-fatty-acids-were-not-independently-associated-with-lipoprotein-subclasses-in-elderly-women
#15
Fatemeh Ramezan Alaghehband, Maria Lankinen, Miika Värri, Joonas Sirola, Heikki Kröger, Arja T Erkkilä
Dietary fatty acids are known to affect serum lipoproteins; however, little is known about the associations between consumption of dietary fatty acids and lipoprotein subclasses. In this study, we hypothesized that there is an association between dietary fatty acids and lipoprotein subclasses and investigated the cross-sectional association of dietary fat intake with subclasses of lipoproteins in elderly women. Altogether, 547 women (aged ≥65 years) who were part of OSTPRE cohort participated. Dietary intake was assessed by 3-day food records, lifestyle, and health information obtained through self-administrated questionnaires, and lipoprotein subclasses were determined by nuclear magnetic resonance spectroscopy...
July 2017: Nutrition Research
https://www.readbyqxmd.com/read/28738813/efficacy-and-safety-of-proprotein-convertase-subtilisin-kexin-type-9-pcsk9-inhibitors-alirocumab-and-evolocumab-a-post-commercialization-study
#16
Joshua Choi, Amir M Khan, Michael Jarmin, Naila Goldenberg, Charles J Glueck, Ping Wang
BACKGROUND: Efficacy-safety of proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors, alirocumab (ALI) and evolocumab (EVO), have previously been evaluated through controlled clinical trials with selective patient groups. Post-commercially, in 69 patients with heterozygous familial hypercholesterolemia (HeFH) and/or cardiovascular disease (CVD) with suboptimal LDL cholesterol (LDLC) lowering on maximal tolerated LDLC therapy, we assessed efficacy and safety of ALI and EVO. METHODS: Post-commercially, we started 29 patients on ALI 75 mg, 18 on ALI 150 mg, and 22 on EVO 140 mg every 2 weeks added to a maximally tolerated LDLC-lowering regimen...
July 24, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28738487/-circadian-blood-pressure-characteristics-in-hospitalized-unstable-angina-pectoris-patients-with-hypertension
#17
W Zhang, H Zhu, S Y Yao, Y Li, J Liu, H Xue
Objective: To define the characteristic of circadian rhythm of blood pressure in unstable angina pectoris (UAP)patients with hypertension and its effects on the cardiovascular events. Methods: It was a prospective study.Based on coronary angiographic results, 742 consecutive hospitalized UAP patients with hypertension and 89 consecutive hospitalized hypertensive patients were recruited between September 2014 and December 2015 in this study. Clinical data and the results of 24-hour ambulatory blood pressure monitoring (ABPM) were analyzed...
July 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28738470/-prevalence-of-hypercholesterolemia-and-influence-factors-in-residents-aged-18-65-years-in-beijing
#18
B Jiang, A J Ma, H Li, K Fang, J Dong, J Xie, K Qi, C Xie, Y Zhou, Y Zhao, Z Dong
Objective: To understand the prevalence of hypercholesterolemia and related risk factors in residents aged 18-65 years in Beijing and provide scientific evidence for the prevention and control of hypercholesterolemia. Methods: The data were collected from Beijing Non-communicable and Chronic Disease Survey and stratified cluster sampling method was used to select study subjects, and questionnaire investigation, physical measurement and laboratory examination were conducted to collect information. Results: The prevalence of hypercholesterolemia and borderline hypercholesterolemia was 6...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738359/predictors-of-subclinical-inflammatory-obesity-plasma-levels-of-leptin-very-low-density-lipoprotein-cholesterol-and-cd14-expression-of-cd16-monocytes
#19
Fernanda Leite, Ângela Leite, Ana Santos, Margarida Lima, Joselina Barbosa, Marco Cosentino, Laura Ribeiro
OBJECTIVE: Predictors of subclinical inflammatory obesity (SIO) can be important tools for early therapeutic interventions in obesity-related comorbidities. Waist circumference (WC) and BMI have different SIO sensitivity. We aimed to i) identify SIO predictors and ii) investigate whether CD16+ monocytes are associated with BMI- (generally) or WC-defined (centrally) obesity. METHODS: Anthropometric and metabolic/endocrine (namely catecholamines, adrenaline and noradrenaline) parameters were evaluated, and CD16+ monocytes were studied by flow cytometry in the peripheral blood from 63 blood donors, and compared and correlated to each other...
July 22, 2017: Obesity Facts
https://www.readbyqxmd.com/read/28736440/repin1-deficiency-in-adipose-tissue-improves-whole-body-insulin-sensitivity-and-lipid-metabolism
#20
N Hesselbarth, A Kunath, M Kern, M Gericke, N Mejhert, M Rydén, M Stumvoll, M Blüher, N Klöting
BACKGROUND/OBJECTIVES: Replication initiator 1 (Repin1) gene encodes for a zinc-finger protein and has been implicated in the regulation of adipocyte cell size and glucose transport in vitro. Here, we investigate the consequences of reduced adipose tissue (AT) Repin1 expression in vivo. SUBJECTS/METHODS: We have inactivated the Repin1 gene in adipose tissue (iARep(-/-)) at an age of four weeks using tamoxifen-inducible gene targeting strategies on the background of C57BL/6NTac mice...
July 24, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
keyword
keyword
41256
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"