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https://www.readbyqxmd.com/read/28926131/region-specific-impairment-of-the-cervical-spinal-cord-sc-in-amyotrophic-lateral-sclerosis-a-preliminary-study-using-sc-templates-and-quantitative-mri-diffusion-tensor-imaging-inhomogeneous-magnetization-transfer
#1
Henitsoa Rasoanandrianina, Aude-Marie Grapperon, Manuel Taso, Olivier M Girard, Guillaume Duhamel, Maxime Guye, Jean-Philippe Ranjeva, Shahram Attarian, Annie Verschueren, Virginie Callot
In this preliminary study, our objective was to investigate the potential of high-resolution anatomical imaging, diffusion tensor imaging (DTI) and conventional/inhomogeneous magnetization transfer imaging [magnetization transfer (MT)/inhomogeneous magnetization transfer (ihMT)] at 3 T, analyzed with template-extracted regions of interest, to measure the atrophy and structural changes of white (WM) and gray (GM) matter spinal cord (SC) occurring in patients with amyotrophic lateral sclerosis (ALS). Ten patients with ALS and 20 age-matched healthy controls were recruited...
September 19, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28923437/in-vitro-studies-with-human-intestinal-epithelial-cell-line-monolayers-for-protein-hazard-characterization
#2
REVIEW
Bryan Delaney
Evaluating the safety of newly expressed proteins in genetically modified (GM) crops is conducted prior to commercialization to determine whether they could present a hazard upon consumption. A multicomponent, weight of evidence approach has been applied to individual proteins that has often included acute oral toxicology studies. Based on resources required to produce and purify the proteins, the number of animals necessary for these studies and the fact that no evidence of hazard has been observed for any of the proteins tested to date, it is questionable whether acute toxicology studies should be conducted for all proteins...
September 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28923424/depletion-of-regulatory-t-cells-by-anti-icos-antibody-enhances-anti-tumor-immunity-of-tumor-cell-vaccine-in-prostate-cancer
#3
Lijun Mo, Qianmei Chen, Xinji Zhang, Xiaojun Shi, Lili Wei, Dianpeng Zheng, Hongwei Li, Jimin Gao, Jinlong Li, Zhiming Hu
ICOS(+)Treg cells exert important immunosuppressive effects in tumor immunity. We adopt a combination approach of ICOS(+)Treg cells depletion with tumor cell vaccine to evaluate anti-tumor immunity in mouse prostate cancer model. Streptavidin (SA)-mGM-CSF surface-modified RM-1 cells were prepared as the vaccine and the mouse subcutaneous prostate tumor model was used to evaluate the immunity. Tumor growth, flow cytometry, immunohistochemistry, immunofluorescence and enzyme linked immunosorbent assay (ELISA) were performed to evaluate the therapeutic effects...
September 15, 2017: Vaccine
https://www.readbyqxmd.com/read/28919702/micro-invasive-glaucoma-surgery-migs-a-review-of-surgical-procedures-using-stents
#4
Lutz E Pillunat, Carl Erb, Anselm Gm Jünemann, Friedemann Kimmich
Over the last decade several novel surgical treatment options and devices for glaucoma have been developed. All these developments aim to cause as little trauma as possible to the eye, to safely, effectively, and sustainably reduce intraocular pressure (IOP), to produce reproducible results, and to be easy to adopt. The term "micro-invasive glaucoma surgery (MIGS)" was used for summarizing all these procedures. Currently MIGS is gaining more and more interest and popularity. The possible reduction of the number of glaucoma medications, the ab interno approach without damaging the conjunctival tissue, and the probably safer procedures compared to incisional surgical methods may explain the increased interest in MIGS...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28919109/long-term-measurements-of-human-inflammatory-cytokines-reveal-complex-baseline-variations-between-individuals
#5
Danlu Wu, Trinh L Dinh, Bruce P Bausk, David R Walt
Comprehensive characterization of the healthy human proteome baseline is essential for personalized medicine. Baseline data are necessary to understand the variation between individuals as well as longitudinal variation within individuals. Many important protein biomarkers, such as cytokines, exist at extremely low or undetectable levels in the healthy state. This paper describes results from a 14-week study of healthy human subjects using ultrasensitive single molecule array (Simoa) assays to measure both intra and intersubject variation of 15 cytokines...
September 14, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28914804/the-role-of-erk-signaling-in-experimental-autoimmune-encephalomyelitis
#6
Katharina Birkner, Beatrice Wasser, Julia Loos, Alexander Plotnikov, Rony Seger, Frauke Zipp, Esther Witsch, Stefan Bittner
Extracellular signal-regulated kinase (ERK) signaling plays a crucial role in regulating immune cell function and has been implicated in autoimmune disorders. To date, all commercially available inhibitors of ERK target upstream components, such as mitogen-activated protein (MAP) kinase/ERK kinase (MEKs), but not ERK itself. Here, we directly inhibit nuclear ERK translocation by a novel pharmacological approach (Glu-Pro-Glu (EPE) peptide), leading to an increase in cytosolic ERK phosphorylation during T helper (Th)17 cell differentiation...
September 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28913893/gonial-angle-measured-by-orthopantomography-as-a-predictor-of-maximum-occlusal-force
#7
Shunta Miwa, Masahiro Wada, Shumei Murakami, Tohru Suganami, Kazunori Ikebe, Yoshinobu Maeda
PURPOSE: To establish the accuracy of measuring the gonial angle on an orthopantomogram (GAO), as defined by the anatomic relationship between the inferior and posterior borders of the mandible. Furthermore, to examine the relationship between GAO and maximum occlusal force (MOF) in the premolar and molar regions of healthy young adults. MATERIALS AND METHODS: Orthopantomograms of dry mandibles were obtained in three orientations in the sagittal plane, to represent variation in image acquisition in clinical settings...
September 15, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28913827/when-more-is-less-an-exploratory-study-of-the-precautionary-reporting-bias-and-its-impact-on-safety-signal-detection
#8
Kevin Klein, Joep Hg Scholl, Marie L De Bruin, Eugène P van Puijenbroek, Hubert Gm Leufkens, Pieter Stolk
Concerns have been expressed that large numbers of non-value added reports have been accumulating in ADR databases, for example via patient support programs. We performed an assessment of the impact of such reports, to which we refer to as 'precautionary reports', on safety signal detection in the Netherlands. The case narratives of ADR reports of three case products were screened with text-mining algorithms to identify those reports that lack a causal relationship with the suspected medicinal product. We demonstrate that precautionary reports impede the optimal use of the pharmacovigilance system by, on the one hand, masking safety signals and, on the other hand, creating spurious signals...
September 15, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28904298/usefulness-of-urinary-biomarkers-for-nephrotoxicity-in-cynomolgus-monkeys-treated-with-gentamicin-cisplatin-and-puromycin-aminonucleoside
#9
Hiroshi Uchino, Junko Fujishima, Kaori Fukuoka, Teppei Iwakiri, Akira Kamikuri, Hidenori Maeda, Kazuhiro Nakama
The objective of this study was to investigate the availability of novel urinary biomarkers (BMs) such as total protein, albumin, β2-microglobulin, clusterin, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL) for the detection of acute nephrotoxicity in cynomolgus monkeys. Animals (total 9 males/3 groups) were administered gentamicin (GM) subcutaneously at 40 mg/kg for 7 days, cisplatin (CDDP) intravenously at 3 mg/kg once and puromycin aminonucleoside (PAN) intravenously at 20 mg/kg for 7 days...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28903911/a-visual-multiplex-pcr-microchip-with-easy-sample-loading
#10
Jian-Wei Chen, Ning Shao, Yuchen Zhang, Yuanshou Zhu, Litao Yang, Sheng-Ce Tao
There is an urgent demand for affordable, rapid and easy-to-use technology to simultaneously detect many different DNA targets within one reaction. Conventional multiplex PCR is an effective methodology to simultaneously amplify different DNA targets. However, its multiplicity is limited due to the intrinsic interference and competition among primer pairs within one tube. Here, we present an easy multiplex PCR microchip system, which can simultaneously detect 54 targets. The design of the microchip is quite simple...
June 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28903738/a-randomized-controlled-trial-of-physical-activity-with-individual-goal-setting-and-volunteer-mentors-to-overcome-sedentary-lifestyle-in-older-adults-at-risk-of-cognitive-decline-the-indigo-trial-protocol
#11
Kay L Cox, Elizabeth V Cyarto, Christopher Etherton-Beer, Kathryn A Ellis, Helman Alfonso, Linda Clare, Danny Liew, David Ames, Leon Flicker, Osvaldo P Almeida, Dina LoGiudice, Nicola T Lautenschlager
BACKGROUND: Increasing physical activity (PA) effectively in those who are inactive is challenging. For those who have subjective memory complaints (SMC) or mild cognitive impairment (MCI) this is a greater challenge necessitating the need for more engaging and innovative approaches. The primary aim of this trial is to determine whether a home-based 6-month PA intervention with individual goal-setting and peer mentors (GM-PA) can significantly increase PA levels in insufficiently active older adults at increased risk of developing Alzheimer's disease (AD)...
September 13, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28902848/the-effect-of-hiv-infection-and-hcv-viremia-on-inflammatory-mediators-and-hepatic-injury-the-women-s-interagency-hiv-study
#12
Sheila M Keating, Jennifer L Dodge, Philip J Norris, John Heitman, Stephen J Gange, Audrey L French, Marshall J Glesby, Brian R Edlin, Patricia S Latham, Maria C Villacres, Ruth M Greenblatt, Marion G Peters
Hepatitis C virus infection induces inflammation and while it is believed that HIV co-infection enhances this response, HIV control may reduce inflammation and liver fibrosis in resolved or viremic HCV infection. Measurement of systemic biomarkers in co-infection could help define the mechanism of inflammation on fibrosis and determine if HIV control reduces liver pathology. A nested case-control study was performed to explore the relationship of systemic biomarkers of inflammation with liver fibrosis in HCV viremic and/or seropositive women with and without HIV infection...
2017: PloS One
https://www.readbyqxmd.com/read/28902809/-peculiarities-of-secretion-of-cytokines-and-chemokines-by-human-blood-monocytes-in-atherosclerosis
#13
N G Nikiforov, V P Karagodin, N V Elizova, A N Orekhov
The study included apparently healthy people, conventionally healthy people predisposed to atherosclerosis, and as well as people with preclinical atherosclerosis (50 subjects in each group). Monocytes were isolated from whole blood and transferred to culture followed by studying pro- and anti-inflammatory activation of monocytes in response to stimulation by interferon-gamma and interleukin-4, respectively. As a marker of pro-inflammatory activation was the level of secretion of tumour necrosis factor-α (TNF-α) in the culture medium measured by means of immunoenzymatic assay...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28892928/anti-inflammatory-and-analgesic-activities-of-topical-formulations-of-pterocarpus-santalinus-powder-in-rat-model-of-chronic-inflammation
#14
Priti Pravin Dhande, Amit O Gupta, Sourav Jain, Jayshree Shriram Dawane
INTRODUCTION: The incidence of arthritis is quite high and there is a need for the search of natural products to halt the progression of disease or provide symptomatic relief without significant adverse effects. AIM: This study aimed at evaluating the anti-inflammatory and analgesic activities of topical Pterocarpus santalinus in an animal model of chronic inflammation. MATERIALS AND METHODS: Albino rats of either sex were divided into five groups of six rats each (Group I - Control, Group II -Gel base, Group III -P...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28890692/white-matter-injury-after-intracerebral-hemorrhage-pathophysiology-and-therapeutic-strategies
#15
REVIEW
Chuanyuan Tao, Xin Hu, Hao Li, Chao You
Intracerebral hemorrhage (ICH) accounts for 10%-30% of all types of stroke. Bleeding within the brain parenchyma causes gray matter (GM) destruction as well as proximal or distal white matter (WM) injury (WMI) due to complex pathophysiological mechanisms. Because WM has a distinct cellular architecture, blood supply pattern and corresponding function, and its response to stroke may vary from that of GM, a better understanding of the characteristics of WMI following ICH is essential and may shed new light on treatment options...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28888896/hormonal-profile-and-follicular-dynamics-concurrent-with-cidr-and-insulin-modified-ovsync-tai-programs-and-their-impacts-on-the-fertility-response-in-buffaloes
#16
A A Ramoun, A M Emara, B A Heleil, S A Darweish, H A Abou-Ghait
Fifty one cyclic Egyptian buffaloes were used to study the hormonal profile and follicular dynamics concurrent with CIDR and insulin modified Ovsync TAI programs and their impacts on the consequent fertility responses. The buffaloes were randomly assigned into 3 ovulation synchronization protocols: Ovsync-alone (n = 13, control) CIDR-sync (n = 20) and Insulin-sync (n = 18). Ovsync-alone protocol consisted of two im injections of 20 μg bueserlin (GnRHa) on Day 0 (GnRH 1) and on Day 9 (GnRH 2) with an im injection of 500 μg of cloprostenol sodium (PGF2 α) on Day 7...
August 19, 2017: Theriogenology
https://www.readbyqxmd.com/read/28886500/peripheral-proinflammatory-cytokines-in-chinese-patients-with-generalised-anxiety-disorder
#17
Zhen Tang, Gang Ye, Xinyun Chen, Mingzhi Pan, Jialin Fu, Tian Fu, Qichun Liu, Zhenyong Gao, David S Baldwin, Ruihua Hou
BACKGROUND: Inflammatory responses and inflammatory cytokines have been implicated in the pathogenesis of affective disorders, particularly major depression. Given the limited evidence relating to the potential role of proinflammatory cytokines in generalised anxiety disorder (GAD), we aimed to examine peripheral proinflammatory cytokines in Chinese patients with GAD. METHODS: A case-controlled cross-sectional study design, with recruitment of 48 patients with first episode GAD and 48 matched healthy controls...
August 31, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28882009/update-on-the-diagnosis-of-invasive-fungal-infection
#18
REVIEW
E Ibáñez-Martínez, A Ruiz-Gaitán, J Pemán-García
The number of patients at risk of suffering invasive fungal infection (IFI) is increasing. Because of its high mortality, new rapid and accurate diagnostic tools are needed. Last advances in invasive candidiasis diagnosis comprise Peptide Nucleic Acid Fluorescent In-Situ Hybridization (PNA-FISH), direct MALDI-TOF or multiplex acid nucleic testing. While all of them rely in positive blood cultures, T2Candida uses PCR coupled with T2Magnetic resonance detection directly in whole blood, allowing detection of 1-3 UFC/mL of Candida in about four hours...
September 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28867884/comparison-of-diagnostic-accuracy-of-non-fasting-dipsi-and-hba1c-with-fasting-who-criteria-for-diagnosis-of-gestational-diabetes-mellitus
#19
Pikee Saxena, Puja Verma, Binita Goswami
BACKGROUND: To compare diagnostic accuracy of non-fasting DIPSI and HbA1c with fasting WHO 1999 as gold standard for diagnosis of gestational diabetes mellitus (GDM). METHODS: Pregnant women attending antenatal clinic underwent a 2-h 75-gm GCT in non-fasting state (DIPSI). HbA1c was also determined at the same sitting. A 2-h 75-gm GCT was repeated for all women after 72 h in a fasting state (WHO criteria). GDM was diagnosed if plasma glucose was ≥140 mg/dl by either test or if HbA1C ≥6%...
October 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28866877/occurrence-and-source-effect-of-novel-brominated-flame-retardants-nbfrs-in-soils-from-five-asian-countries-and-its-relationship-with-pbdes
#20
Wen-Long Li, Wan-Li Ma, Zifeng Zhang, Liyan Liu, Wei-Wei Song, Hongliang Jia, Yong-Sheng Ding, Haruhiko Nakata, Nguyen Hung Minh, Ravindra Kumar Sinha, Hyo-Bang Moon, Kurunthachalam Kannan, Ed Sverko, Yi-Fan Li
This paper presents the first comprehensive survey of 19 novel brominated flame retardants (NBFRs) in soil samples collected across five Asian countries. High variability in concentrations of all NBFRs was found in soils with the geometric mean (GM) values ranging from 0.50 ng/g dry weight (dw) in Vietnam to 540 ng/g dw in the vicinity of a BFR-manufactory in China. In urban/rural/background locations, the GM concentrations of ∑19NBFRs decreased in the order of Japan > South Korea > China > India > Vietnam...
September 3, 2017: Environmental Science & Technology
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