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https://www.readbyqxmd.com/read/28101972/an-evaluation-of-the-quality-of-evidence-available-to-inform-current-bone-conduction-hearing-device-national-policy
#1
Rishi Mandavia, Alex Carter, Nadine Haram, Elias Mossialos, Anne Gm Schilder
OBJECTIVES: In 2016 NHS England published the commissioning policy on Bone Conducting Hearing Devices (BCHDs). This policy was informed by updated evidence on the clinical and cost effectiveness of BCHDs as well as by the 2013 Bone Anchored Hearing Aid (BAHA) policy. Commissioning policies set the criteria for service delivery and therefore have a major impact on the care received by patients. It is important that stakeholders have a good appreciation of the available evidence informing policy, since this will promote engagement both with the policy as well as with future research leading on from the policy...
January 18, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28097694/serial-cytokine-alterations-and-abnormal-neuroimaging-in-newborn-infants-with-encephalopathy
#2
Fiona M O'Hare, R William G Watson, Amanda O'Neill, Ricardo Segurado, Deirdre Sweetman, Paul Downey, Eoghan Mooney, John Murphy, Veronica Donoghue, Eleanor J Molloy
AIM: Inflammatory cytokines may play a role in the final common pathway in the pathogenesis of hypoxic-ischaemic injury in experimental models. We aimed to profile the systemic pro- and anti-inflammatory response over the first week of life in term infants at risk of neonatal encephalopathy. METHOD: In a tertiary referral university neonatal intensive care unit, serial blood samples were analysed from 41 term infants (requiring resuscitation at birth) in this prospective observational pilot study...
January 17, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28095856/baff-index-and-cxcl13-levels-in-the-cerebrospinal-fluid-associate-respectively-with-intrathecal-igg-synthesis-and-cortical-atrophy-in-multiple-sclerosis-at-clinical-onset
#3
M Puthenparampil, L Federle, S Miante, A Zito, E Toffanin, S Ruggero, M Ermani, S Pravato, D Poggiali, P Perini, F Rinaldi, P Gallo
BACKGROUND: B lymphocytes are thought to play a relevant role in multiple sclerosis (MS) pathology. The in vivo analysis of intrathecally produced B cell-related cytokines may help to clarify the mechanisms of B cell recruitment and immunoglobulin production within the central nervous system (CNS) in MS. METHODS: Paired cerebrospinal fluid (CSF) and serum specimens from 40 clinically isolated syndrome suggestive of MS or early-onset relapsing-remitting MS patients (CIS/eRRMS) and 17 healthy controls (HC) were analyzed for the intrathecal synthesis of IgG (quantitative formulae and IgG oligoclonal bands, IgGOB), CXCL13, BAFF, and IL-21...
January 17, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28081289/transgenic-cotton-expressing-cry10aa-toxin-confers-high-resistance-to-the-cotton-boll-weevil
#4
Thuanne Pires Ribeiro, Fabricio Barbosa Monteiro Arraes, Isabela Tristan Lourenço-Tessutti, Marilia Santos Silva, Maria Eugênia Lisei-de-Sá, Wagner Alexandre Lucena, Leonardo Lima Pepino Macedo, Janaina Nascimento Lima, Regina Maria Santos Amorim, Sinara Artico, Márcio Alves-Ferreira, Maria Cristina Mattar Silva, Maria Fatima Grossi-de-Sa
Genetically modified (GM) cotton events that effectively control cotton boll weevil (CBW), which is the most destructive cotton insect pest in South America, are reported here for the first time. This work presents the successful development of new GM cotton with high resistance to CBW conferred by Cry10Aa toxin, a protein encoded by entomopathogenic Bacillus thuringiensis (Bt) gene. The plant transformation vector harbouring cry10Aa gene driven by the cotton ubiquitination-related promoter uceA1.7 was introduced into a Brazilian cotton cultivar by biolistic transformation...
January 12, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28073161/the-pnpla3-i148m-variant-modulates-the-fibrogenic-phenotype-of-human-hepatic-stellate-cells
#5
Francesca Virginia Bruschi, Thierry Claudel, Matteo Tardelli, Alessandra Caligiuri, Thomas M Stulnig, Fabio Marra, Michael Trauner
: The genetic polymorphism I148M of PNPLA3 is robustly associated with hepatic steatosis and its progression to steatohepatitis, fibrosis and cancer. Hepatic stellate cells (HSCs) are key players in the development of liver fibrosis, but the role of PNPLA3 and its variant I148M in this process is poorly understood. Here we analyzed the expression of PNPLA3 during human HSC activation and thereby explored how a PNPLA3 variant impacts on hepatic fibrogenesis. We show that PNPLA3 gene and protein expression increase during the early phases of activation and remain elevated in fully activated HSCs (p<0...
January 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28070745/considering-total-intracranial-volume-and-other-nuisance-variables-in-brain-voxel-based-morphometry-in-idiopathic-pd
#6
Samuel Crowley, Haiqing Huang, Jared Tanner, Qing Zho, Nadine A Schwab, Loren Hizel, Daniel Ramon, Babette Brumback, Mingzhou Ding, Catherine C Price
Voxel-based morphometry (VBM) studies of Parkinson's disease (PD), have yielded mixed results, possibly due to several studies not accounting for common nuisance variables (age, sex, and total intracranial volume [TICV]). TICV is particularly important because there is evidence for larger TICV in PD. We explored the influence of these covariates on VBM by 1) comparing PD patients and controls before adding covariates, after adding age and sex, and after adding age, sex and TICV, and 2) by comparing controls split into large and small TICV before and after controlling for TICV, with age and sex accounted for in both analyses...
January 9, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28063941/nitro-oleic-acid-regulates-growth-factor-induced-differentiation-of-bone-marrow-derived-macrophages
#7
Hana Verescakova, Gabriela Ambrozova, Lukas Kubala, Tomas Perecko, Adolf Koudelka, Ondrej Vasicek, Tanja K Rudolph, Anna Klinke, Steven R Woodcock, Bruce A Freeman, Michaela Pekarova
Many diseases accompanied by chronic inflammation are connected with dysregulated activation of macrophage subpopulations. Recently, we reported that nitro-fatty acids (NO2-FAs), products of metabolic and inflammatory reactions of nitric oxide and nitrite, modulate macrophage and other immune cell functions. Bone marrow cell suspensions were isolated from mice and supplemented with macrophage colony-stimulating factor (M-CSF) or granulocyte-macrophage colony-stimulating factor (GM-CSF) in combination with NO2-OA for different times...
January 4, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28060553/determinants-of-willingness-to-consume-genetically-modified-gm-foods-and-the-potential-expenditure-in-nigeria
#8
L A Popoola, M A Otitoju, L Tanko
Consumption decision and likely expenditure are critical fundamentals that may ultimately shape the future of GM crops development and deployment in Nigeria. The present study constituted an attempt to examine factors of significance with bearing influence on these key consumer-led issues. Structured and pre-tested questionnaire were employed to elicit response from consumers. In all, 232 responses were analysed with Heckman two-stage selection model. The socio-economic data shows that majority of respondents (45...
January 6, 2017: GM Crops & Food
https://www.readbyqxmd.com/read/28054724/learning-based-3t-brain-mri-segmentation-with-guidance-from-7t-mri-labeling
#9
Minghui Deng, Renping Yu, Li Wang, Feng Shi, Pew-Thian Yap, Dinggang Shen
PURPOSE: Segmentation of brain magnetic resonance (MR) images into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) is crucial for brain structural measurement and disease diagnosis. Learning-based segmentation methods depend largely on the availability of good training ground truth. However, the commonly used 3T MR images are of insufficient image quality and often exhibit poor intensity contrast between WM, GM, and CSF. Therefore, they are not ideal for providing good ground truth label data for training learning-based methods...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/28054389/health-effects-of-laser-printer-emissions-a-controlled-exposure-study
#10
Stefan Karrasch, Myriam Simon, Britta Herbig, Jeanette Langner, Stefan Seeger, Angelika Kronseder, Stefan Peters, Gisela Dietrich-Gümperlein, Rudolf Schierl, Dennis Nowak, Rudolf A Jörres
Ultrafine particles emitted from laser printers are suspected to elicit adverse health effects. We performed 75-minute exposures to emissions of laser printing devices (LPDs) in a standardized, randomized, cross-over manner in 23 healthy subjects, 14 mild, stable asthmatics and 15 persons reporting symptoms associated with LPD emissions. Low level exposures (LLE) ranged at the particle background (3,000 cm(-3) ), high level exposures (HLE) at 100,000 cm(-3) . Examinations before and after exposures included spirometry, body plethysmography, transfer factors for CO and NO (TLCO, TLNO), bronchial and alveolar NO, cytokines in serum and nasal secretions (IL-1β, IL-5, IL-6, IL-8, GM-CSF, IFNγ, TNFα), serum ECP, and IgE...
January 5, 2017: Indoor Air
https://www.readbyqxmd.com/read/28049086/structural-and-metabolic-differentiation-between-bipolar-disorder-with-psychosis-and-substance-induced-psychosis-an-integrated-mri-pet-study
#11
A C Altamura, G Delvecchio, G Marotta, L Oldani, A Pigoni, V Ciappolino, E Caletti, C Rovera, C Dobrea, C Arici, B Benatti, G Camuri, C Prunas, R A Paoli, B Dell'osso, C Cinnante, F M Triulzi, P Brambilla
BACKGROUND: Bipolar disorder (BD) may be characterized by the presence of psychotic symptoms and comorbid substance abuse. In this context, structural and metabolic dysfunctions have been reported in both BD with psychosis and addiction, separately. In this study, we aimed at identifying neural substrates differentiating psychotic BD, with or without substance abuse, versus substance-induced psychosis (SIP) by coupling, for the first time, magnetic resonance imaging (MRI) and positron emission tomography (PET)...
December 30, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28048122/su-f-j-182-investigation-of-systems-for-improved-accuracy-in-clinical-y-90-percent-delivered-calculations
#12
R McBeth, D Elder, A Kesner
PURPOSE: Y-90 Selective Internal Radiation Therapy (SIRT) is used to treat liver tumors, and by nature has variability in the percent of the intended dose that is actually delivered. To determine the quality of the administration, pre and post activity measurements are taken, and used to infer percent delivered. Vendor specifications indicate the use of an ion chamber to take these measurements. In our work, we investigated the accuracy of ion chambers, and compared them to other detector systems...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047710/su-c-209-01-validation-of-the-simulated-detectability-metric-g-rod-using-the-experimental-generalized-measured-relative-object-detectability-metric-gm-rod
#13
M Russ, C Ionita, D Bednarek, S Rudin
PURPOSE: The Generalized Relative Object Detectability (G-ROD) family of ideal observer metrics are a well-characterized set of task-based metrics used for quantitatively comparing imaging systems that include the detector, focal spot geometry and scatter characteristics on the basis of system abilities in imaging a given simulated object. The G-ROD metric takes the integral over spatial frequencies of the Fourier transform of a simulated object function weighted with the detector generalized DQE (GDQE), divided by the comparable integral for another detector...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047297/tu-fg-209-05-demonstration-of-the-line-focus-principle-using-the-generalized-measured-relative-object-detectability-gm-rod-metric
#14
M Russ, A Shankar, A Lau, D Bednarek, S Rudin
PURPOSE: Demonstrate and quantify the augmented resolution due to focalspot size decrease in images acquired on the anode side of the field, for both small and medium (0.3 and 0.6mm) focal-spot sizes using the experimental task-based GM-ROD metric. Theoretical calculations have shown that a medium focal-spot can achieve the resolution of a small focal-spot if acquired with a tilted anode, effectively providing a higher-output small focal-spot. METHODS: The MAF-CMOS (micro-angiographic fluoroscopic complementary-metal-oxide semiconductor) detector (75µm pixel pitch) imaged two copper wire segments of different diameter and a pipeline stent at the central axis and on the anode side of the beam, achieved by tilting the x-ray C-arm (Toshiba Infinix) to 6° and realigning the detector with the perpendicular ray to correct for x-ray obliquity...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047188/su-f-t-461-dosimetric-evaluation-of-indigenous-farmer-type-chamber-far65-gb-for-reference-dosimetry-of-fff-mv-photon-beam
#15
P Patwe, V Mhatre, P Dandekar
PURPOSE: Indigenous Farmer type chamber FAR 65 GB is a reference class 0.6 cc ion chamber. It can be used for dosimetric evaluation of photon and high energy electron beams. We studied dosimetric characteristics of the chamber for 6MV and 10MV Flattening filter free FFF photon beams available on trueBEAM STx Linac. METHODS: The study was carried out on trueBEAM STx Linac having 6 and 10 MV FFF photon beam with maximum dose rate 1400 and 2400 MU per min respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046904/th-cd-202-05-dect-based-tissue-segmentation-as-input-to-monte-carlo-simulations-for-proton-treatment-verification-using-pet-imaging
#16
B Berndt, T Tessonnier, F Schwarz, J Bauer, M Wuerl, F Kamp, C Thieke, C Belka, F Verhaegen, M Reiser, W Sommer, G Dedes, G Landry, K Parodi
PURPOSE: To improve agreement of predicted and measured positron emitter yields in patients, after proton irradiation for PET-based treatment verification, using a novel dual energy CT (DECT) tissue segmentation approach, overcoming known deficiencies from single energy CT (SECT). METHODS: DECT head scans of 5 trauma patients were segmented and compared to existing decomposition methods with a first focus on the brain. For validation purposes, three brain equivalent solutions [water, white matter (WM) and grey matter (GM) - equivalent with respect to their reference carbon and oxygen contents and CT numbers at 90kVp and 150kVp] were prepared from water, ethanol, sucrose and salt...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046892/su-g-brc-17-using-generalized-mean-for-equivalent-square-estimation
#17
S Zhou, Q Wu, Q Fan, Y Lei, S Li, X Li, R Ma, S Wang, X Wang, D Zheng, X Zhu, C Enke
PURPOSE: Equivalent Square (ES) is a widely used concept in radiotherapy. It enables us to determine many important quantities for a rectangular treatment field, without measurement, based on the corresponding values from its ES field. In this study, we propose a Generalized Mean (GM) type ES formula and compare it with other established formulae using benchmark datasets. METHODS: Our GM approach is expressed as ES=(w•fx^α+(1-w)•fy^α)^(1/α), where fx, fy, α, and w represent field sizes, power index, and a weighting factor, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046822/su-f-i-17-white-matter-track-based-analysis-at-limbic-abnormalities-in-cognitive-impairment
#18
R Juh, T Suh, J Han, C Kim, C Oh
PURPOSE: Mild cognitive impairment with depression (MCID) is common and associated with disability and cognitive impairment, with high probability of relapse. Hypothesize that a sign of WM disintegration would be observed in MCID than MCI nondepression (MCIND), especially in frontal and limbic regions and patients with depression would show reduced GM density in the hippocampus, amygdala, anterior gyrus cingulate, and dorsolateral prefrontal cortex (DLPFC) and dorsomedial prefrontal cortex (DMPFC) the abnormalities of long association fiber tracts integrity are correlated with geriatric depression...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046604/su-f-t-300-impact-of-electron-density-modeling-of-arccheck-cylindricaldiode-array-on-3dvh-patient-specific-qa-software-tool-analysis
#19
P Patwe, V Mhatre, P Dandekar
PURPOSE: 3DVH software is a patient specific quality assurance tool which estimates the 3D dose to the patient specific geometry with the help of Planned Dose Perturbation algorithm. The purpose of this study is to evaluate the impact of HU value of ArcCHECK phantom entered in Eclipse TPS on 3D dose & DVH QA analysis. METHODS: Manufacturer of ArcCHECK phantom provides CT data set of phantom & recommends considering it as a homogeneous phantom with electron density (1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043548/discordance-between-genexpert-assay-and-conventional-drug-susceptibility-testing-in-detecting-rifampicin-resistant-tuberculosis-a-perspective-of-the-line-probe-assay
#20
Ruqaya M Ali, Ahmed A Alsudani
BACKGROUND: Early detection for tuberculosis (TB) and rifampicin-resistant TB (RRTB) is crucial for proper control of this disease. WHO recommended the use of the GeneXpert assay at district level to cover these two public health demands? A study evaluated the diagnostic impact of the GeneXpert assay in detecting TB and RRTB. Odd results were observed in this study in the form of discordance between the GeneXpert assay and the conventional culture and drug-susceptibility testing (DST)...
December 2016: International Journal of Mycobacteriology
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