keyword
https://read.qxmd.com/read/38467692/single-cell-rna-sequencing-reveals-critical-modulators-of-extracellular-matrix-of-penile-cavernous-cells-in-erectile-dysfunction
#21
JOURNAL ARTICLE
Chao Luo, Yaqian Peng, Jiang Gu, Tao Li, Qiang Wang, Xiaolan Qi, Anyang Wei
Erectile dysfunction (ED) is a common and difficult to treat disease, and has a high incidence rate worldwide. As a marker of vascular disease, ED usually occurs in cardiovascular disease, 2-5 years prior to cardiovascular disease events. The extracellular matrix (ECM) network plays a crucial role in maintaining cardiac homeostasis, not only by providing structural support, but also by promoting force transmission, and by transducing key signals to intracardiac cells. However, the relationship between ECM and ED remains unclear...
March 11, 2024: Scientific Reports
https://read.qxmd.com/read/38467040/role-of-stereotactic-radiosurgery-for-recurrent-skull-base-acinic-cell-carcinoma-illustrative-case
#22
JOURNAL ARTICLE
Tomohiro Yoshihira, Motoyuki Umekawa, Yuki Shinya, Hirotaka Hasegawa, Masahiro Shin, Yodai Kikuchi, Yuki Saito, Kenji Kondo, Atsuto Katano, Aya Shinozaki-Ushiku, Nobuhito Saito
BACKGROUND: Acinic cell carcinomas (AcCCs), rare malignancies of the salivary glands, often recur and metastasize, particularly in the skull base. Conventional radical resection can be invasive for skull base AcCCs adjacent to cranial nerves and major vasculature, and the effectiveness of stereotactic radiosurgery (SRS) as an alternative is not well established. OBSERVATIONS: This case report details the application of SRS for recurrent skull base AcCCs. A 71-year-old male with a history of resection for a right mandibular AcCC 23 years earlier experienced tumor recurrence involving the right cavernous sinus and nasal cavity...
March 11, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38466209/transorbital-embolization-of-a-direct-carotid-cavernous-fistula-with-vascular-steal-phenomenon
#23
JOURNAL ARTICLE
Lucy I Mudie, Michael T Yen
No abstract text is available yet for this article.
March 11, 2024: Orbit
https://read.qxmd.com/read/38462632/computed-tomography-angiography-of-liver-alveococcosis-a-case-report
#24
JOURNAL ARTICLE
Saodatkhon Magzumova, Umidjon Isroilov, Nigora Djuraeva, Zarina Khaybullina, Aybek Amirkhamzaev, Nargiza Vakhidova, Khanum Abdukhalimova, Alisher Sultanov, Bekhzod Abdullaev
BACKGROUND: Alveococcosis, helminthiasis caused by the larvae of Alveococcus multilocularis, is characterized by the formation of parasitic nodes in the liver. This clinical case is a rare occurrence of liver alveococcosis in Uzbekistan. CASE PRESENTATION: We present a case of a 33-year-old Asian woman from Uzbekistan who complained of discomfort in the epigastric region and right hypochondrium, along with general weakness. She had been experiencing symptoms for 5 months when a routine ultrasound examination revealed a structural formation in the liver...
March 11, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38460444/enhancing-diagnostic-accuracy-through-neuroimaging-revisions-in-pediatric-pseudotumor-cerebri-syndrome-a-cross-sectional-study
#25
JOURNAL ARTICLE
Amira Masri, Nosaiba Al Ryalat, Azmy Hadidy, Ashjan Ahmad Al-Shakkah, Majd Ali, Mira Al Jaberi, Raghad Shihadat, Abdallah Rayyan, Mohammad AlMasri, Lina Abunameh
BACKGROUND: This cross-sectional study aimed to report all neuroimaging findings suggestive of raised intracranial pressure in children with pseudotumor cerebri syndrome (PTCS), before and after re-review by two neuroradiologists. METHODS: We included 48 children aged <18 years diagnosed with PTCS between 2016 and 2021. Clinical and radiological data were obtained from their medical files. Two neuroradiologists independently re-reviewed all neuroimages, and the average of their assessments was compared with the initial neuroimaging reports; an additional review was done to analyze inter- and intraclass correlation...
February 18, 2024: Pediatric Neurology
https://read.qxmd.com/read/38457787/eloquent-noneloquence-redefinition-of-cortical-eloquence-based-on-outcomes-of-superficial-cerebral-cavernous-malformation-resection
#26
JOURNAL ARTICLE
Benjamin K Hendricks, Lea Scherschinski, Jubran H Jubran, Nicholas B Dadario, Katherine Karahalios, Dimitri Benner, Danielle VanBrabant, Michael T Lawton
OBJECTIVE: Cerebral cavernous malformations (CMs) are pathological lesions that cause discrete cortical disruption with hemorrhage, and their transcortical resections can cause additional iatrogenic disruption. The analysis of microsurgically treated CMs might identify areas of "eloquent noneloquence," or cortex that is associated with unexpected deficits when injured or transgressed. METHODS: Patients from a consecutive microsurgical series of superficial cerebral CMs who presented to the authors' center over a 13-year period were retrospectively analyzed...
March 8, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38457246/hspb1-promotes-tumor-invasion-by-inducing-angiogenesis-in-pitnets
#27
JOURNAL ARTICLE
Bin Li, Sida Zhao, Yiyuan Chen, Hua Gao, Weiyan Xie, Hongyun Wang, Peng Zhao, Chuzhong Li, Yazhuo Zhang
The clinical diagnosis and treatment of Pituitary neuroendocrine tumors (PitNETs) that invade the cavernous sinus are fraught with difficulties and challenges. Exploring the biological characteristics involved in the occurrence and development of PitNETs that invade the cavernous sinus will help to elucidate the mechanism of cavernous sinus invasion. There are differences between intrasellar tumors (IST) and cavernous sinus-invasion tumors (CST) in ultra-microstructure, tumor microenvironment (TME), gene expression, and signaling pathways...
March 1, 2024: Endocrine-related Cancer
https://read.qxmd.com/read/38455718/case-report-first-attempt-by-off-label-use-of-tenecteplase-to-treat-acute-extensive-portal-venous-system-thrombosis
#28
Qianqian Li, Ying Piao, Yongguo Zhang, Xingshun Qi
Acute extensive portal venous system thrombosis (PVST) can cause lethal complications. Herein, we have for the first time reported the use of anticoagulation combined with systemic thrombolysis by tenecteplase in a male patient with a diagnosis of acute extensive PVST but without liver cirrhosis. After thrombolytic therapy, abdominal pain obviously alleviated. However, urinary bleeding developed, which was reversible by stopping thrombolytic drugs. Finally, this case developed cavernous transformation of the portal vein without portal venous recanalization...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38455700/giant-cell-arteritis-presenting-as-multiple-ischaemic-strokes-a-successful-case-of-endovascular-treatment
#29
JOURNAL ARTICLE
Ana Órfão, Carolina Saca, Inês Alexandre, Ana Maria Oliveira, João Fernandes Serôdio, João Barreira, Teresa Mesquita
UNLABELLED: Giant cell arteritis (GCA) may manifest with aggressive intracranial stenosis resistant to medical therapy, and patients may develop refractory neurologic deficits and cerebral infarcts, making GCA a life-threatening condition. We report the case of a 68-year-old woman recently diagnosed with GCA, medicated with prednisolone 60 mg daily. Two weeks later, the patient was admitted to our Stroke Unit after a sudden episode of global aphasia. Magnetic resonance angiography showed two recent ischaemic lesions, besides an erythrocyte sedimentation rate of 17 mm/hour...
2024: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/38455102/human-dental-pulp-stem-stromal-cells-in-clinical-practice
#30
EDITORIAL
Mohammed E Grawish
Dental pulp stem/stromal cells (DPSCs) are fibroblast-like, neural crest-derived, and multipotent cells that can differentiate into several lineages. They are relatively easy to isolate from healthy and inflamed pulps, with little ethical concerns and can be successfully cryopreserved and thawed. The therapeutic effects of DPSCs derived from animal or human sources have been extensively studied through in-vitro and in-vivo animal experiments and the findings indicated that DPSCs are effective not only for dental diseases but also for systemic diseases...
February 26, 2024: World Journal of Stem Cells
https://read.qxmd.com/read/38454561/ectopic-pituitary-neuroendocrine-tumors-adenomas-around-the-sella-turcica
#31
JOURNAL ARTICLE
Mustafa Kemal Demir, Önder Ertem, Deniz Kılıç, Okan Akıncı, Özge Ecertaştan, Deniz Konya, Türker Kılıç
Functional or non-secretory ectopic pituitary neuroendocrine tumors (PitNET) can form around the sella turcica during the development of the adenohypophysis by differentiating and detaching from the pharyngeal roof. These tumors usually appear in the sphenoid sinus, clivus, cavernous sinus, infundibulum, and suprasellar cistern. Ectopic PitNETs typically display the characteristic magnetic resonance imaging findings of pituitary adenomas. However, preoperative diagnosis of PitNETs is usually challenging because of the variety of clinical and imaging presentations, locations, and sizes...
March 8, 2024: Balkan Medical Journal
https://read.qxmd.com/read/38454521/orbital-infarction-syndrome-following-mechanical-thrombectomy-in-internal-carotid-artery-occlusion-a-case-report
#32
JOURNAL ARTICLE
Binh Q Tran, Lanh C Nguyen, Tinh T Trinh, An T T Vo, Minh V Do, Minh Q Tran, Khanh C Tran, Loan H T Tran, Duc T Ha
BACKGROUND: Orbital ischemic syndrome is a rare entity. The clinical signs typically demonstrate acute loss of visual acuity, chemosis, proptosis, ptosis, and total ophthalmoparesis. We report a case of a man who suffered an acute internal carotid artery occlusion and developed orbital ischemic syndrome after a mechanical thrombectomy. CASE PRESENTATION: A 57-year-old Vietnamese (Kinh ethnicity) man was brought to the emergency room with complaints of a speech disturbance, facial palsy, and severe weakness of the left arm and leg, which had started 4 hours earlier, after waking up...
March 8, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38453564/transaxillary-endoscopic-subfascial-operation-for-persistent-muscular-torticollis-in-pediatric-patients-a-13-year-retrospective-study-in-taiwan
#33
JOURNAL ARTICLE
Nai-Chen Cheng, Yu-Han Chen, Yu-Ling Wu, Yu-Tang Chang
BACKGROUND: The endoscopic surgery for persistent muscular torticollis has been well-described and most are subcutaneous working caverns. As the sternocleidomastoid muscle is located beneath the deep cervical fascia that corresponds to the pectoral fascia, this study aimed to review our results of the transaxillary approach under the pectoral fascia and the deep cervical fascia. METHODS: Between November 2009 and January 2022, pediatric patients with persistent muscular torticollis receiving transaxillary endoscopic subfascial operation were retrospectively reviewed and analyzed...
November 11, 2023: Pediatrics and Neonatology
https://read.qxmd.com/read/38452319/palatal-myoclonus-due-to-cortical-cavernous-malformation
#34
JOURNAL ARTICLE
Paulina G Diaz, Aryeh R Zolin, Apostolos J Tsiouris, Saad Mir
No abstract text is available yet for this article.
April 9, 2024: Neurology
https://read.qxmd.com/read/38451321/shh-regulates-penile-morphology-and-smooth-muscle-through-a-mechanism-involving-bmp4-and-grem1
#35
JOURNAL ARTICLE
Jiangping Deng, Sarah Martin, Timothy Searl, Samuel Ohlander, Daniel A Harrington, Kevin T McVary, Carol A Podlasek
BACKGROUND: The cavernous nerve (CN) is frequently damaged in prostatectomy and diabetic patients with erectile dysfunction (ED), initiating changes in penile morphology including an acute and intense phase of apoptosis in penile smooth muscle and increased collagen, which alter penile architecture and make corpora cavernosa smooth muscle less able to relax in response to neurotransmitters, resulting in ED. AIM: Sonic hedgehog (SHH) is a critical regulator of penile smooth muscle, and SHH treatment suppresses penile remodeling after CN injury through an unknown mechanism; we examine if part of the mechanism of how SHH preserves smooth muscle after CN injury involves bone morphogenetic protein 4 (BMP4) and gremlin1 (GREM1)...
March 6, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38451311/bmp4-and-grem1-are-targets-of-shh-signaling-and-downstream-regulators-of-collagen-in-the-penis
#36
JOURNAL ARTICLE
Jiangping Deng, Timothy Searl, Samuel Ohlander, Danuta Dynda, Daniel A Harrington, Kevin T McVary, Carol A Podlasek
BACKGROUND: Cavernous nerve (CN) injury, caused by prostatectomy and diabetes, initiates a remodeling process (smooth muscle apoptosis and increased collagen) in the corpora cavernosa of the penis of patients and animal models that is an underlying cause of erectile dysfunction (ED), and the Sonic hedgehog (SHH) pathway plays an essential role in the response of the penis to denervation, as collagen increases with SHH inhibition and decreases with SHH treatment. AIM: We examined if part of the mechanism of how SHH prevents penile remodeling and increased collagen with CN injury involves bone morphogenetic protein 4 (BMP4) and gremlin1 (GREM1) and examined the relationship between SHH, BMP4, GREM1, and collagen in penis of ED patients and rat models of CN injury, SHH inhibition, and SHH, BMP4, and GREM1 treatment...
March 6, 2024: Journal of Sexual Medicine
https://read.qxmd.com/read/38451297/giant-brainstem-cavernoma-in-pediatrics-diagnosis-and-treatment-case-report
#37
JOURNAL ARTICLE
María Eugenia Badaloni, Javier Danilo Gonzalez Ramos
INTRODUCTION: Brain cavernomas or cavernous angiomas are a rare vascular malformation in the general population, even more so in pediatric patients. Their incidence in this group is less than 5% of all vascular malformations. They are typically found in the cerebral hemispheres in cortico-subcortical locations and, more rarely, in the brainstem. OBJECTIVE: To describe the diagnosis, treatment, and follow-up of a case involving a pediatric patient with a giant cavernoma in the brainstem at J...
March 7, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38451106/microsurgical-resection-of-a-lateral-pontine-arteriovenous-malformation-masquerading-as-a-cavernous-malformation-2-dimensional-operative-video
#38
JOURNAL ARTICLE
Christopher S Graffeo, Lea Scherschinski, Jacob F Baranoski, Visish M Srinivasan, Michael T Lawton
Although cavernous malformations (CMs) often demonstrate characteristic T2 heterogeneity and gadolinium enhancement, whereas arteriovenous malformations (AVMs) appear as tangles of T2 hypointense flow voids, small lesions in deep locations may have equivocal features on preoperative imaging.1-4 This video presents an unusual case of a lateral pontine AVM masquerading as a CM. The patient presented with sudden-onset headache, dizziness, double vision, and left facial numbness. Diagnostic imaging findings suggested a hemorrhagic left lateral pontine mass lesion, most consistent with brainstem CM...
March 7, 2024: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/38451102/sacrificing-internal-carotid-artery-external-carotid-artery-radial-artery-middle-cerebral-artery-bypass-for-the-treatment-of-complex-intracranial-artery-cavernous-sinus-aneurysms
#39
JOURNAL ARTICLE
Fudi Chu, MaoYuan Song, Zheng Zhang, Chunxiao Pang, JinPeng Wang
The treatment of complex intracranial aneurysms has always been a great challenge in neurosurgery. Craniotomy has a high risk of clipping, there is a risk of rupture at any time, endovascular embolization is relatively low risk, but expensive and easy to relapse, the best treatment needs to be further discussed. Cavernous sinus aneurysms with pituitary adenomas are rare. This case reports a case of complex intracranial aneurysms. Chief complaints are: (1) blepharoptosis with blurred vision for 1 year, (2) headache for 3 days, and (3) digital subtraction angiography showed right internal carotid artery cavernous sinus aneurysm...
March 7, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38451089/endoscopic-supracerebellar-infratentorial-transpineal-approach-for-posterior-medial-thalamic-lesions-surgical-technique-and-clinical-experience
#40
JOURNAL ARTICLE
Tao Xie, Shuang Liu, Xiaobiao Zhang, Liangliang Yang, Tengfei Liu, Ping Chen, Zeyang Li
BACKGROUND AND OBJECTIVES: Accessing lesions in the posterior-medial thalamus can be challenging because of their deep location and intricate neurovascular anatomy. This study aims to describe the techniques and feasibility of the endoscopic supracerebellar infratentorial transpineal approach for treating posterior-medial thalamus lesions. METHODS: We reviewed and analyzed the clinical outcomes and endoscopic surgical experience of 11 patients with posterior-medial thalamic lesions...
March 7, 2024: Operative Neurosurgery (Hagerstown, Md.)
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