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https://www.readbyqxmd.com/read/29793194/simultaneous-determination-of-18-psychoactive-agents-and-6-metabolites-in-plasma-using-lc-ms-ms-and-application-to-actual-plasma-samples-from-conscription-candidates
#1
Dongeun Park, Hyeyoung Choi, Moonhee Jang, Hyejin Chang, Sanghee Woo, Wonkyung Yang
In Korea, an increasing number of people attempt to evade military conscription by posing as mental health patients. To verify the authenticity of mental illness, there is a need to detect wide range of psychoactive agents in biological specimens of conscription candidates. In this study, we developed and validated a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of 18 psychoactive agents and 6 metabolites in human plasma. The method was characterized by the use of a simple, fast and cheap protein precipitation as sample preparation, a rapid run time (11min) and a low volume of plasma sample (200μL)...
April 22, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29792387/resveratrol-prevents-high-calorie-diet-induced-learning-and-memory-dysfunction-in-juvenile-c57bl-6j-mice
#2
Bao-Lei Xu, Hui Zhang, Li-Na Ma, Wen Dong, Zhi-Wei Zhao, Jing-Shuang Zhang, Yu-Lan Wang, Xu Zhang, Rong Wang
OBJECTIVE: Because resveratrol (RSV) has been shown to improve learning and memory, so we investigated the potential benefit of RSV on learning and memory deficits in juvenile mice fed with a HC diet and explored the molecular mechanisms underlying this process. METHODS: Six-week-old C57BL/6J mice were divided into three different diet groups: control, HC diet, and HC + RSV diet. Serum insulin and insulin-like growth factor 1 (IGF-1) levels were measured using enzyme-linked immunosorbent assays...
May 24, 2018: Neurological Research
https://www.readbyqxmd.com/read/29788999/the-first-case-of-multiple-pulmonary-granulomas-with-amyloid-deposition-in-a-dental-technician-a-rare-manifestation-as-an-occupational-lung-disease
#3
Taizou Hirano, Tadahisa Numakura, Hiroshi Moriyama, Ryoko Saito, Yutaka Shishikura, Jun Shiihara, Hisatoshi Sugiura, Masakazu Ichinose
BACKGROUND: Occupational lung diseases, such as pneumoconiosis, are one of the health problems of dental workers that have been receiving increasing interest. Pulmonary amyloidosis is a heterogenous group of diseases, and can be classified into primary (idiopathic) and secondary (associated with various inflammatory diseases, hereditary, or neoplastic). To date, the development of pulmonary amyloidosis in dental workers has not been reported. CASE PRESENTATION: A 58-year-old Japanese female presented with chest discomfort and low-grade fever that has persisted for 2 months...
May 22, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29788705/the-risk-of-microalbuminuria-by-obesity-phenotypes-according-to-metabolic-health-and-obesity-the-korean-national-health-and-nutrition-examination-survey-2011-2014
#4
Inyoung Choi, Heesun Moon, So Young Kang, Hyeonyoung Ko, Jinyoung Shin, Jungkwon Lee
BACKGROUND: The present study aimed at identifying the difference in the risk of microalbuminuria among individuals with various obesity phenotypes in terms of metabolic health and obesity. METHODS: This cross-sectional study included 15,268 individuals and used data from the National Health and Nutrition Survey conducted from 2011 to 2014. Obesity was defined as body mass index ≥25 kg/m². Metabolically unhealthy was defined as meeting two or more of the following criteria: systolic and diastolic blood pressure ≥130/85 mm Hg or current use of hypertensive drugs; triglyceride level ≥150 mg/dL; high-density lipoprotein level <40/50 mg/dL (in both men and women); and fasting blood glucose level ≥100 mg/dL or current use of oral antidiabetic medications...
May 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29788018/brain-immunohistopathology-in-a-patient-with-autoimmune-glial-fibrillary-acidic-protein-astrocytopathy
#5
Yaqing Shu, Youming Long, Yanyu Chang, Rui Li, Xiaobo Sun, Yuge Wang, Yinong Huang, Jing Li, Jianning Chen, Yu Yang, Zhengqi Lu, Xueqiang Hu, Allan G Kermode, Wei Qiu
BACKGROUND: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a novel meningoencephalomyelitis. However, the pathogenesis of this disease is unclear. We therefore examined a brain biopsy from a patient with autoimmune GFAP astrocytopathy by immunohistopathology. METHODS: We examined brain biopsy sections from a patient with autoimmune GFAP astrocytopathy using hematoxylin and eosin (HE) and Luxol fast blue (LFB) staining, and immunostaining with antibodies for CD4, CD8, CD3, CD20, CD68, CD138, Neu-N, GFAP, myelin oligodendrocyte glycoprotein (MOG), and aquaporin-4 (AQP4)...
May 22, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29787926/examining-community-and-consumer-food-environments-for-children-an-urban-suburban-rural-comparison-in-southwestern-ontario
#6
Catherine M DuBreck, Richard C Sadler, Godwin Arku, Jason A Gilliland
The aim of this study is to evaluate how retail food environments for children in the City of London and Middlesex County, Ontario, Canada, vary according to level of urbanicity and level of socioeconomic distress. Urbanicity in this study is defined as a neighbourhood's designation as urban, suburban, or rural. We assessed community food environments (e.g., the type, location, and accessibility of food outlets) using 800m and 1600m network buffers (school zones) around all public and private elementary schools, and we calculated and compared density of junk food opportunities (JFO) (e...
May 8, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29787870/oral-hydroxysafflor-yellow-a-reduces-obesity-in-mice-by-modulating-the-gut-microbiota-and-serum-metabolism
#7
Juan Liu, Shijun Yue, Zhirui Yan, Wuwen Feng, Xintong Meng, Aiting Wang, Cheng Peng, Changyun Wang, Dan Yan
Given the high and increasing prevalence of obesity, the safe and effective treatment of obesity would be beneficial. Here, we examined whether oral hydroxysafflor yellow A (HSYA), an active compound from the dried florets of Carthamus tinctorius L., can reduce high-fat (HF) diet-induced obesity in C57BL/6 J mice. Our results showed that the average body weight of HF group treated by HSYA was significantly lower than that of the HF group (P < 0.01). HSYA also reduced fat accumulation, ameliorated insulin resistance, restored glucose homeostasis, reduced inflammation, enhanced intestinal integrity, and increased short-chain fatty acids ((SCFAs)) production in HF diet-fed mice...
May 19, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29786656/temperature-effects-on-force-and-actin%C3%A2-myosin-interaction-in-muscle-a-look-back-on-some-experimental-findings
#8
REVIEW
K W Ranatunga
Observations made in temperature studies on mammalian muscle during force development, shortening, and lengthening, are re-examined. The isometric force in active muscle goes up substantially on warming from less than 10 °C to temperatures closer to physiological (>30 °C), and the sigmoidal temperature dependence of this force has a half-maximum at ~10 °C. During steady shortening, when force is decreased to a steady level, the sigmoidal curve is more pronounced and shifted to higher temperatures, whereas, in lengthening muscle, the curve is shifted to lower temperatures, and there is a less marked increase with temperature...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29786520/impact-of-piglet-oral-vaccination-against-tuberculosis-in-endemic-free-ranging-wild-boar-populations
#9
Iratxe Díez-Delgado, Iker A Sevilla, Beatriz Romero, Eleanor Tanner, Jose A Barasona, Andrew R White, Peter W W Lurz, Mike Boots, José de la Fuente, Lucas Dominguez, Joaquin Vicente, Joseba M Garrido, Ramón A Juste, Alicia Aranaz, Christian Gortazar
The Eurasian wild boar (Sus scrofa) is the main wild reservoir of the Mycobacterium tuberculosis complex in Mediterranean woodlands and a key risk factor for cattle tuberculosis (TB) breakdowns. Wild boar vaccination therefore has the potential to be a valuable tool for TB control. We tested two orally delivered vaccines, heat-inactivated Mycobacterium bovis (IV) and BCG, in four sites (two per vaccine type: one Managed and one Natural or unmanaged) during four years. TB was also monitored in 15 unvaccinated sites (spatial control), as well as in all sites from one year prior to intervention (temporal control)...
July 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29786448/serum-rbp4-positively-correlates-with-triglyceride-level-but-not-with-bmi-fat-mass-and-insulin-resistance-in-healthy-obese-and-non-obese-individuals
#10
Emilia Korek, Magdalena Gibas-Dorna, Zuzanna Chęcińska-Maciejewska, Hanna Krauss, Małgorzata Łagiedo-Żelazowska, Barbara Kołodziejczak, Paweł Bogdański
PURPOSE: Retinol binding protein 4 (RBP4) has recently been identified as an adipokine possibly involved in the development of impaired glucose metabolism. We aimed to test serum RBP4 in healthy non-obese individuals and in patients with well-characterized phenotype: obesity without confounding effects of diabetes, metabolic syndrome or dyslipidemia. Additionally, we examined whether serum RBP4 is associated with anthropometric parameters, insulin resistance and blood lipid parameters...
May 22, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29785693/massive-transfusion-the-revised-assessment-of-bleeding-and-transfusion-rabt-score
#11
Bellal Joseph, Muhammad Khan, Michael Truitt, Faisal Jehan, Narong Kulvatunyou, Asad Azim, Arpana Jain, Muhammad Zeeshan, Andrew Tang, Terence O'Keeffe
BACKGROUND: Massive transfusion (MT) is a lifesaving treatment for trauma patients with hemorrhagic shock, assessed by Assessment of Blood Consumption (ABC) Score based on mechanism of injury, systolic blood pressure (SBP), tachycardia, and FAST exam. The aim of this study was to assess the performance of ABC score by replacing hypotension and tachycardia; with Shock Index (SI) > 1.0 and including pelvic fractures. METHODS: We performed a 2-year (2014-2015) analysis of all high-level trauma activations and excluded patients dead on arrival...
May 21, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29784317/sensitive-determination-of-cyclopiazonic-acid-in-dry-cured-ham-using-a-quechers-method-and-uhplc-ms-ms
#12
Belén Peromingo, Mar Rodríguez, Félix Núñez, Antonio Silva, Alicia Rodríguez
An extraction method and an UHPLC-MS/MS method for the quantification of CPA in dry-cured ham were developed and validated. To optimise detection and quantification of CPA, the composition of mobile phase, flow rates, gradient-related factors and solvents used for resuspension of dry extracts were evaluated. Besides, four extraction methods were tested. The best peak shape and resolution were obtained by eluting the mobile phase consisting in acetic acid-ammonium acetate buffer pH 5.75/methanol in gradient mode at a flow rate of 0...
October 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29783969/association-between-thyroid-hormones-and-the-components-of-metabolic-syndrome
#13
Jieun Jang, Youngsook Kim, Jaeyong Shin, Sang Ah Lee, Young Choi, Eun-Cheol Park
BACKGROUND: Thyroid hormones are known to have direct and indirect effects on metabolism. Individuals with metabolic syndrome, a disease that is growing in incidence at a rapid rate, are at higher risk for cardiovascular disease, diabetes, and cancer. The aim of this study was to identify whether significant correlations exist between thyroid hormone levels and components of the metabolic syndrome in the general population of Korea. METHODS: The data were collected from the sixth Korea National Health and Nutrition Examination Surveys from 2013 to 2015...
May 21, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29783226/algorithm-of-adenoiditis-treatment-in-adults-depending-on-the-pharyngeal-tonsil-hypertrophy-stage
#14
Yevhen V Smiianov, Vladyslav A Smiianov, Inna A Sniehirova, Olha I Smiianova
OBJECTIVE: Introduction: Implementation of the endoscopic technologies while the upper airways diseases gave opportunity to diagnose the adenoid vegetation in adults. The aim: Тo offer effective algorithm of curing adults for adenoiditis, depending on the degree of pharyngeal tonsil hypertrophy. PATIENTS AND METHODS: Materials and methods: 43 patients aged 18 - 55 with hypertrophy of pharyngeal tonsil were examined. Depending on the degree of hypertrophy three clinical groups of patients was created: the first one receiving only conservative treatment, the second one receiving conservative therapy and radiowaveradiation coagulation with the apparatus "SURGITRON" and the third one receiving the endoscopic shave adenotomy...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783064/aerobic-resistance-or-combined-training-a-systematic-review-and-meta-analysis-of-exercise-to-reduce-cardiovascular-risk-in-adults-with-metabolic-syndrome
#15
Michael A Wewege, Jeanette M Thom, Kerry-Anne Rye, Belinda J Parmenter
BACKGROUND AND AIMS: Exercise is beneficial to individuals with metabolic syndrome (MetS). An understudied group, who represent the majority of the MetS population, are individuals who have not developed diabetes. This review examined aerobic, resistance and combined (aerobic + resistance) exercise for cardiovascular risk factors in MetS without diabetes. METHODS: Eight electronic databases were searched up to September 2017 for randomised controlled trials >4 weeks in duration that compared an exercise intervention to the non-exercise control in MetS without diabetes...
May 3, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29780779/sonographic-evaluation-of-bladder-wall-thickness-in-women-with-lower-urinary-tract-dysfunction
#16
Un Ju Shin, Jihye Koh, Jiwon Song, Soyun Park, Eun Joo Park, Chung-Hoon Kim, Sung Hoon Kim, Byung Moon Kang, Hee Dong Chae
Objective: To investigate the correlation between bladder wall thickness (BWT) measured by ultrasonography and lower urinary tract dysfunction (LUTD) in patients with lower urinary tract symptoms (LUTS). Methods: Forty-eight women with LUTS who underwent urodynamic study and BWT by ultrasonography as outpatients were studied. We assessed LUTS during a medical examination by interview. The thinnest part of the bladder wall was measured by a transabdominal ultrasonography...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29780059/the-relationship-between-vitronectin-and-hepatic-insulin-resistance-in-type-2-diabetes-mellitus
#17
Yan Cao, Xinyu Li, Chong Lu, Xiaorong Zhan
The World Health Organization (WHO) estimates that approximately 300 million people will suffer from diabetes mellitus by 2025. Type 2 diabetes mellitus (T2DM) is much more prevalent. T2DM comprises approximately 90% of diabetes mellitus cases, and it is caused by a combination of insulin resistance and inadequate compensatory insulin secretory response. In this study, we aimed to compare the plasma vitronectin (VN) levels between patients with T2DM and insulin resistance (IR) and healthy controls. Seventy patients with IR and 70 age- and body mass index (BMI)-matched healthy controls were included in the study...
May 18, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29779782/the-association-of-neck-circumference-with-risk-of-metabolic-syndrome-and-its-components-in-adults-a-systematic-review-and-meta-analysis
#18
N Namazi, B Larijani, P J Surkan, L Azadbakht
BACKGROUND & AIMS: Several prior studies suggested that neck circumference (NC) is a reliable diagnostic tool for risk of metabolic syndrome (MetS) and its features. However, not all studies support this view. Therefore, we aimed to perform a meta-analysis to summarize the association between NC with MetS and its components in adult populations. METHODS AND RESULTS: PubMed/Medline, Web of Knowledge, and Scopus electronic databases were searched until May 31, 2017 to find relevant English-language papers...
March 21, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29779023/parathyroid-hormone-fibroblast-growth-factor-23-and-parameters-of-phosphate-reabsorption
#19
Kenneth R Phelps, Darius L Mason
BACKGROUND: The serum phosphorus concentration ([P]s) is the sum of EP/Ccr and TRP/Ccr, where Ccr is creatinine clearance and EP and TRP are rates of excretion and reabsorption of phosphate. In chronic kidney disease (CKD), parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) mediate reduction of TRP/Ccr, and [PTH] and [FGF23] are linear functions of EP/Ccr. If controls and patients with CKD are considered together, TRP/Ccr is a hyperbolic function of EP/Ccr. Given these observations, we hypothesized that hyperbolas would describe relationships of phosphate reabsorption to [PTH] and [FGF23]...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29778220/development-of-a-qpcr-assay-to-detect-and-quantify-ichthyotoxic-flagellates-along-the-norwegian-coast-and-the-first-norwegian-record-of-fibrocapsa-japonica-raphidophyceae
#20
Anette Engesmo, David Strand, Sandra Gran-Stadniczeñko, Bente Edvardsen, Linda K Medlin, Wenche Eikrem
Blooms of ichthyotoxic microalgae pose a great challenge to the aquaculture industry world-wide, and there is a need for fast and specific methods for their detection and quantification in monitoring programs. In this study, quantitative real-time PCR (qPCR) assays for the detection and enumeration of three ichthyotoxic flagellates: the dinoflagellate Karenia mikimotoi (Miyake & Kominami ex Oda) Hansen & Moestrup and the two raphidophytes Heterosigma akashiwo (Hada) Hada ex Hara & Chihara and Fibrocapsa japonica Toriumi & Takano were developed...
May 2018: Harmful Algae
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